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<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKI8</accession>
    <name>A0A9W9WKI8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Restriction endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_009364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785681.1">
        <property type="nucleotide sequence ID" value="XM_056938959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKI8"/>
    <dbReference type="GeneID" id="81629209"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5466635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="29847" checksum="C7299307825A082B" modified="2023-11-08" version="1">MSKVLKQTLLDLKDKIRQGYIGDLYYDTITKEDFTSLYSKLSTTSRRPRYLYDHKNLILQVRMPASRHEDIVDQLKEMINTKLRAAGIDRATTWSNLAPLYTLGDISAEPDGCWGPASDNNPTVVMEVGNSETSGQLLLDGRHWLENIHSSVQLSILVKLKKNPDIIQISIWELDHSRYLRPLRTSHRLVKRTQFAEITRSDPIHRVTITSTNSPAELRIPFTMFTGPSPPPGVNMAGDMIISQQDLLDLARFHFVTRNGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKP7</accession>
    <name>A0A9W9WKP7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_008892</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785864.1">
        <property type="nucleotide sequence ID" value="XM_056938487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKP7"/>
    <dbReference type="GeneID" id="81628737"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5469274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="66" mass="7212" checksum="B3527F48CCF18FEF" modified="2023-11-08" version="1">MIFASWDGFQGKLASKETVFMIFEGAMIAIACICLNIGHPGLWLGSPPKLRTGEVDTEFNTVHGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL31</accession>
    <name>A0A9W9WL31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trehalose-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_009089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786061.1">
        <property type="nucleotide sequence ID" value="XM_056938684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL31"/>
    <dbReference type="GeneID" id="81628934"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000617">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000003">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000131">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF123">
        <property type="entry name" value="TREHALOSE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5469471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="946" mass="106148" checksum="DCE19A409AB665A0" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLH5</accession>
    <name>A0A9W9WLH5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_009328</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786300.1">
        <property type="nucleotide sequence ID" value="XM_056938923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLH5"/>
    <dbReference type="GeneID" id="81629173"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:endochitinase activity"/>
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        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Class V chitinase, putative"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Endochitinase-like"/>
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    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chitin-bd_1"/>
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        <property type="entry name" value="Chitin-binding_1_CS"/>
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        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
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        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
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        <property type="entry name" value="GH"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF337">
        <property type="entry name" value="CHITINASE"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHIT_BIND_I_2"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GH18_2"/>
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    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="3 10" id="KW-0147">Chitin-binding</keyword>
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    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
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    <feature type="chain" id="PRO_5040790908" description="chitinase" evidence="13">
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            <begin position="18"/>
            <end position="428"/>
        </location>
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        <location>
            <begin position="18"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="14">
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            <begin position="302"/>
            <end position="345"/>
        </location>
    </feature>
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            <begin position="313"/>
            <end position="325"/>
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            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
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        </source>
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    <evidence type="ECO:0000256" key="2">
        <source>
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            <dbReference type="ARBA" id="ARBA00022669"/>
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        <source>
            <dbReference type="EMBL" id="KAJ5469710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="428" mass="46536" checksum="4115848551C55ED2" modified="2023-11-08" version="1">MWKALACGLLAAQGAAALRFGMYIDQYHTVDLPGSDQTGGIDHAIMAFAPTSIFNSDSTPSFTPFESVDTMRKRFGPNTKLMIAIGGWGDTAGFSDGAKDDASRKRFAKNVAAMLDANKFDGVDIDWEYPGGNGQDYKQVPNSAKVGEIETYPKFLAAIREAIGDKILSIATPGRLQDFIAFTKQQGPEIFKSVDMVNVMTYDLMNRRDNVTAHQTDVEGSLKTIQAYLDIGAPPEKLNLGFAYYAKWFTTDPNSDCKEHPIGCHVVKLENDDGSDNGKSGAFTFEKGNMAAPPSNLKASSNGKCGYSEGSKCPNGSCCSQYGNCGTGDDFCMAGCQSDYGTCKGISITDSWRRAVKDGMTDEKAGGQYYWDETTNLFWTWDTPELITRKFADIVKAKNLGGVMAWSLGEDTYKFEHLKAMQDGVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQR6</accession>
    <name>A0A9W9WQR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786400.1">
        <property type="nucleotide sequence ID" value="XM_056938392.1"/>
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    <dbReference type="GeneID" id="81628642"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="88" mass="10122" checksum="BACC2B0460E00D5E" modified="2023-11-08" version="1">MTGAKRCSIQAPRKAPDADAIREQLRPQRGGFDPTSDNIRAWLKQNIDEPNKEFEWFEGKYQIATHLIYYTVNKIARGFIADSSNSYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WT56</accession>
    <name>A0A9W9WT56_9EURO</name>
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        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_008103</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786795.1">
        <property type="nucleotide sequence ID" value="XM_056937703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WT56"/>
    <dbReference type="GeneID" id="81627953"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF6">
        <property type="entry name" value="SPECIFIC TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="342"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="413"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="555"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="685"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="756"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="578"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="758"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="775"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5475037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="870" mass="94851" checksum="F46A5C5ABFA64A61" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WT98</accession>
    <name>A0A9W9WT98_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_008182</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786874.1">
        <property type="nucleotide sequence ID" value="XM_056937782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WT98"/>
    <dbReference type="GeneID" id="81628032"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5475116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="38829" checksum="07A56452A306C40B" modified="2023-11-08" version="1">MPSHWWENHMRRSNGYFGCEITRDNDEATGFNMWTFFQTKEVNSDTDYKWSKFNIFTRWIAKTNKTAILLFEPNKSPNPFDKIALNADLLGDPFWVLTHVLDELCKLQDNAVWLIRDSIRMIEKEKTPQEGQTPNYRKLHDIARHSIHVIETLDVTLLTVEQIIEGHKTYVTPQSTSPQILTTPSKDHIWQDVHARLIASQGFLASQQQRAIANEKRLKNEIQLTFQMVARSEATVMIEDSAALKTIAIVTYTFLPPTFICALFSMSFFNYDRQLGWAMSPDFWIYWAIALPASALSVGLWYYWQKSPPSRTEQEKVDRFSRRMDRLQMHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTL2</accession>
    <name>A0A9W9WTL2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787033.1">
        <property type="nucleotide sequence ID" value="XM_056937941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTL2"/>
    <dbReference type="GeneID" id="81628191"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="684"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5475275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1045" mass="113733" checksum="64844D10107482C1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUF5</accession>
    <name>A0A9W9WUF5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787465.1">
        <property type="nucleotide sequence ID" value="XM_056937600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUF5"/>
    <dbReference type="GeneID" id="81627849"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="236" mass="25397" checksum="BD6C76A3DF2818A9" modified="2023-11-08" version="1">MNGTDLNLATGVLFGGSLLLMQLPSNPLIARVRVGLAMGQSLRVRQPQYHLQAGDATSSSISEGLAMVLTDKRIYIFILLQHASLFLQMEPPVPFLDYCQILGYDKIETLLIPGPVWIVTFFVTAAGGVLFTDTTNQYHSMPIGAVSVDQIIIVWVVNSFPRPLVKLSPAIALENMIGNTASICGSYMWSSTSGPGYIPGGDGGARIAVSVAVIALAIRLIHIRLKKRLEAAESSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUH8</accession>
    <name>A0A9W9WUH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_008016</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787482.1">
        <property type="nucleotide sequence ID" value="XM_056937617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUH8"/>
    <dbReference type="GeneID" id="81627866"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046589">
        <property type="term" value="F:ribonuclease T1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104:SF2">
        <property type="entry name" value="GUANYL-SPECIFIC RIBONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040937409" evidence="6">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5475729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="141" mass="15427" checksum="173F672455574903" modified="2023-11-08" version="1">MFFSTKSIVLYGLIALTSASPVAEFSKRAKLGDFLCPDGTLIEEKDVREAYHECRRVDDRTYGSYPKYFGNQAGTGKVFSNIPDGTDLREFPIVIGGTYNGGQPGAYRVVTDYKDNRGDFRGVMQHTGATVGGAYSACTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUN6</accession>
    <name>A0A9W9WUN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787600.1">
        <property type="nucleotide sequence ID" value="XM_056936801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUN6"/>
    <dbReference type="GeneID" id="81627050"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="70" mass="7597" checksum="F0B847F23C8DF64D" modified="2023-11-08" version="1">MRDDDSSLKAARARSFMSKIGAQTSATTRSPSLRRRKEPAIHDQSWFTGGIDGFANALSGAIPWEIVGCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUP9</accession>
    <name>A0A9W9WUP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Efflux pump himE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_007156</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787556.1">
        <property type="nucleotide sequence ID" value="XM_056936757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUP9"/>
    <dbReference type="GeneID" id="81627006"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5477012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="305" mass="33518" checksum="ED4BFC2EE3B18CB1" modified="2023-11-08" version="1">MASNNTQVYVPCTLQTCPLSMATIPYQPNLGANATFLVIFALALAVQIWSSIKYRTWTHLVGMTGGLLLEIVGYVGRIMLHYNPFNFNNFVIYLVCLTVAPAFISAVIYICFYRVTIIYGQSLFGLKPRILAIIFICCDIICLILQAAGGAIASLSNGTSREARAQGDMGINIMIAGLVFQVISLLAFLSCAAYYLWSMRRRYSEPKATTVKRGLWYAFLTSLGVAAIAIFVRSVYRVAELREGFQGKLAGNEALFMILEGAMIVITTVALTVFHPGYCLGVPWKVQAAETSMLLESRGSKDGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUR4</accession>
    <name>A0A9W9WUR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787628.1">
        <property type="nucleotide sequence ID" value="XM_056936829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUR4"/>
    <dbReference type="GeneID" id="81627078"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015416">
        <property type="entry name" value="Znf_H2C2_histone_UAS-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF2">
        <property type="entry name" value="PROTEIN SPT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09337">
        <property type="entry name" value="zf-H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="66"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5477084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="528" mass="59319" checksum="19851577CDEE9997" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV62</accession>
    <name>A0A9W9WV62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">von Willebrand and RING finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_007459</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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        </source>
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        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
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        <property type="entry name" value="NODB_dom"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5040852118" evidence="7">
        <location>
            <begin position="20"/>
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        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="8">
        <location>
            <begin position="59"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5477286.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="258" mass="28732" checksum="FBBEB99B221C0ACD" modified="2023-11-08" version="1">MYHLASCLAVLSIVTRSSATPVLPTAPSPQSILTSSTLLSRDEPQLPYGQVIDRCTVPGTIAFAFDDGPYIYTEHVLDLLADAGMSATFFLCGDWEGNIYDFSHVVNRTLSEGHQIGSHSHYNLTTVPYQTILKEMYALEKAFSDILGFVPTYTRTPWMHVNELVLSALADLQYHVIGASILTDDKANNSPDRTERSAEMFREGLEQGGSISLAHETQRYTAESLVEKMIEEVEKRGLKAVTVGECLGHPQELWYRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1Y6</accession>
    <name>A0A9W9X1Y6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788341.1">
        <property type="nucleotide sequence ID" value="XM_056936406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1Y6"/>
    <dbReference type="GeneID" id="81626655"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5480911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="96" mass="11475" checksum="BDAD39CE87A0FDD7" modified="2023-11-08" version="1">MCRQYYTLFAWCSCEEDAGYTPCTGLRLNNCRGVSIETVHMHCFCNSHATRGFKTQKEIRKEERKIRRQSQDSLGEKASLGRRLYQWYQWKGIWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2G9</accession>
    <name>A0A9W9X2G9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788460.1">
        <property type="nucleotide sequence ID" value="XM_056936525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2G9"/>
    <dbReference type="GeneID" id="81626774"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5481030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="523" mass="56986" checksum="A65061849F6672EC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2L8</accession>
    <name>A0A9W9X2L8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arylamine N-acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788535.1">
        <property type="nucleotide sequence ID" value="XM_056936600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2L8"/>
    <dbReference type="GeneID" id="81626849"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5481105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="39687" checksum="319DE8351CD81D23" modified="2023-11-08" version="1">MTQLPLDDESRTRYSNAELHAYFERIKLPQKYRDSIVLKDPTQALTKQHGLPLLVALTRHHTCNVPFENLVLHYTSHKAVTLDLTALFQKFVRRQLGGRCMENNSFFATVLRSLGYEVRNCAGRVSRAMSPYTEVRRNQGDTYDGWNHMLNLVWLEDEWYVTDVGMGAMGPNLPYPLRDGFETVSVAPREIRIQHRPIAETYTSRSGKGPEPPKLWCYDICYKPDDEAGKKWLPVYCFTETEFLPQDYEVMSWYTSKHPRSFFTKEIMCTKMIMDEGLEVIVGNLTLFNHTLTKAIGAERTMVKECKTEEDRLQVLEEMMQVHLTDEEKNSISDDQKLGHVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3T1</accession>
    <name>A0A9W9X3T1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789002.1">
        <property type="nucleotide sequence ID" value="XM_056936078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X3T1"/>
    <dbReference type="GeneID" id="81626327"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5483030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="216" mass="24586" checksum="72826A431A60BE3A" modified="2023-11-08" version="1">MSQPKDTGRENPGPGPLTPPERGAQVPRSKPHDYAASDPEFVPGFSFLRVEQARHMAKDEDRTRLINSITDDIVATVIRIRSYFKSGVLSDGNIYQLDTVLQTIGHNNLKAQERLERKLCRLERKHCRLQQEYVRLARGMDAMGTKYTARLASLEHRTNTLRHRLDWLETGGQLHESRSRRKTALPQTLEKKESPELMAIKIEATEATEGEGEISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X519</accession>
    <name>A0A9W9X519_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD/PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789246.1">
        <property type="nucleotide sequence ID" value="XM_056935374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X519"/>
    <dbReference type="GeneID" id="81625623"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.50">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594:SF1">
        <property type="entry name" value="HD_PDEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03035)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5483976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="187" mass="20341" checksum="5538BBCBE691EC59" modified="2023-11-08" version="1">MDVSSTQFQTLYHSMLTFVNTCMAGHDPSHNPAHVHRVATLANTILEAEQKRHSPRPLDAAVIKLAALLHDIGDRKYLPQLADPHSHENIDPKTMVQVALLKHGAPAELAAKVQMVVSHVSYTTECKDPAVVRRLIEEEGYPELAVVQDADRLDAIGAIGIGRTFTFLGGAGEEVCGGEWVGDGELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5C5</accession>
    <name>A0A9W9X5C5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">L-type lectin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_005920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789394.1">
        <property type="nucleotide sequence ID" value="XM_056935522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5C5"/>
    <dbReference type="GeneID" id="81625771"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07308">
        <property type="entry name" value="lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF45">
        <property type="entry name" value="RE50040P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040822527" evidence="8">
        <location>
            <begin position="18"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="9">
        <location>
            <begin position="32"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5484124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="361" mass="40359" checksum="8029B67D69138369" modified="2023-11-08" version="1">MHIPIISSLLCLAGLSAVPVNAYSGSNPDIKAIPLRTHSLTPPYLDSDFQSRWFDFGGDTVIRADKYVRLTADRPSQQGWVFSRVPLTATNWEVRSEEKAQFRPLRLQRLALEMRKLRAQANQSRPLQIEVEFEIHGNGNLHGDGLALWLTKQRATQGPVFGSTDRFEGLGIFIDTYKNNRPGVSFPYVMAMMGDGETTYDQAHDGKANELAGCSARGLRNAPVPTKLRLTYFQDKSLSLDLQYKTEDTWTNCFNLNAEQTKIAIPSVAYLGLSAETGELSDNHDIISVKSENLYALNRHTPGGSKADPKSRNSGGNSYPTPHDSGSWSWFFVKFILFIGVCVGGYFGWTFYRTKVRASRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5H8</accession>
    <name>A0A9W9X5H8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Post-SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_005982</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789456.1">
        <property type="nucleotide sequence ID" value="XM_056935584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5H8"/>
    <dbReference type="GeneID" id="81625833"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053201">
        <property type="entry name" value="Flavunoidine_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350:SF19">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="19"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="6">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5484186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18300" checksum="CC255253BB1A2212" modified="2023-11-08" version="1">MPSVVETTSPAEPVPSHPDRIRVNRSTKAFGSGAYSLIDLPAGAVFAPITGITPGTKAYTTVQTGPDTHIELNSDLVYCNHSCDPSLVFDMSRMEVRVVDDKPLRAGDALTFFYPSTEWEMDQPFQCTCGASECRGWISGAKTMSAEELEGYWLNGFIVELLNERQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5R3</accession>
    <name>A0A9W9X5R3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789607.1">
        <property type="nucleotide sequence ID" value="XM_056934413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5R3"/>
    <dbReference type="GeneID" id="81624662"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5484823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="281" mass="30513" checksum="3772416AA1712ECF" modified="2023-11-08" version="1">MASANFSLFSRADIQQLVSEYPDDNLSVSGQADLISRLLGQSSPDSKSIVAVMWQLGELMADLVFVVDPLTTTPWYLHLVLTQDTLFLALHKLRLDAAPATFGAYLDALLASFATDPLSAGVLAIHTHASEQWLEIKDDLFDRLGSEQGQVDPTVPCQPVMPASLATGSVPVHTQDVADRKRRPLEEGEVSQTPAKLAPKKGKRRAEEPAPGDELRGKLSWGTPVPNDKEQEEMPRGPSTPRDQGPSTPQPIVLRDGSVIMPAWSATFGPPPGAPRGRKWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X651</accession>
    <name>A0A9W9X651_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Noranthrone monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_004990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the anthrone oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789786.1">
        <property type="nucleotide sequence ID" value="XM_056934592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X651"/>
    <dbReference type="GeneID" id="81624841"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF1">
        <property type="entry name" value="DUF1772-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5485002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="18116" checksum="606EF706FD63474F" modified="2023-11-08" version="1">MDSSGSLGLGLAQAIGISGAAWLSGNIFALSINTVAALQESIHEDKVSPSIIAKQWSRMYAKGKTQNPPIAAAVAASFFYLAWSAPSDTFPANRATLSLSGLYSSAAVVTLGIVPFTLLAMVGTNNSLHRQAKSEVEVPEAETMELLGKWSYLNVIRGCFPLVGAVLGLMTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X658</accession>
    <name>A0A9W9X658_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADH-ubiquinone oxidoreductase 10.5 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_004829</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789625.1">
        <property type="nucleotide sequence ID" value="XM_056934431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X658"/>
    <dbReference type="GeneID" id="81624680"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016464">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B8 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005822">
        <property type="entry name" value="NDUA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="10">
        <location>
            <begin position="62"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5484841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="131" mass="14595" checksum="6F004138441F72D5" modified="2023-11-08" version="1">MSGKYVFSKGLKELRFLFCQSSEQSAATRSVHQPSTSDRALLPLHGALSLQNGSDQLADSMRSIHRSFINRAYPTMKKHNPHTPIMIREAAGTEPRVFARYAFGKETQEALSGLSDSQIEERITNLVKQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6A1</accession>
    <name>A0A9W9X6A1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Carbamoyl phosphate synthase arginine-specific large chain, mitochondrial</fullName>
            <ecNumber evidence="14">6.3.4.16</ecNumber>
            <ecNumber evidence="5">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Ammonium-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">N7539_005127</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="14"/>
    <dbReference type="EC" id="6.3.5.5" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789923.1">
        <property type="nucleotide sequence ID" value="XM_056934729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6A1"/>
    <dbReference type="GeneID" id="81624978"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000015">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="221"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="758"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="23">
        <location>
            <begin position="1022"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00068891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAJ5485139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1172" mass="128572" checksum="76D24E4B4B9CBEF0" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6Q8</accession>
    <name>A0A9W9X6Q8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_005079</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789875.1">
        <property type="nucleotide sequence ID" value="XM_056934681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6Q8"/>
    <dbReference type="GeneID" id="81624930"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019529">
        <property type="entry name" value="Syntaxin-18_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10496">
        <property type="entry name" value="Syntaxin-18_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="322"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="68"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="252"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5485091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="412" mass="44879" checksum="ECC76D30EA296520" modified="2023-11-08" version="1">MTDLTPALDTILSSKHGRSIPPPATRTPCTEVADEFLKEAYRINSHIASLLKYLHSIRHAYLSTAAASASSRRHPNKDHHAHISPRSHYSTSYFSPTRTPNPSAHHTHLTEPERDQIDSSTALLLRDLATSIANLSSAETLRQETSASILRKKYGHSAAGALLWRWAGGGSALDESSAQEGKSAEQVDAEERAKTLAGVREGVLWFLRRGLDRVAGVQREMVEKRIERAREKEKSVLYKNASAAAAAAAAGNGSTCHTSDPSSSPTSGPAGSSARQSAYQSLDPSIPAPDATTLSEAETARIEAQLSPEQLQLFAEENDTMLKHYEDTLGKIQNAEKSLLEISSLQETLVSHLATQEEYISQLVSDVDTTQSNVGRGNKELKRATERRSTAQAVFWGTVGLCTWLVVWDLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7B7</accession>
    <name>A0A9W9X7B7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SNF2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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                <person name="Nielsen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790643.1">
        <property type="nucleotide sequence ID" value="XM_056933102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XC08"/>
    <dbReference type="GeneID" id="81623351"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5488610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="178" mass="20757" checksum="EE3F6456C9187792" modified="2023-11-08" version="1">MPSQSDAIKEAYNAGIFEGNRHSLYRDMFRWSQELRRGEQVHMNIASKLDDFSKGWRTGQLKEIAQLNLQSDTDVQRYICRKVDRLCDAMDWVADILRRRLACEVDIADMLVALAVHVGRSRYLCMRTPLPDLYADGLDAFAEEEHAFWWKVHRNAFVREISSCLMESMKCQCCRCVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCE7</accession>
    <name>A0A9W9XCE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">mRNA export protein mlo3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_003719</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790862.1">
        <property type="nucleotide sequence ID" value="XM_056933321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCE7"/>
    <dbReference type="GeneID" id="81623570"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="64"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5488829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="257" mass="26774" checksum="F608232200BF0812" modified="2023-11-08" version="1">MSANLDKSLDDLVGSRRQSARRRRGAGRRTAPKPSVGGVKKASKAPKAAAKVVHPTPTAPTPSSKIIVSGLPSDVSEANIKEYFAKSAGPVKKVMLTYNQNGTSRGIASIIFNKADTAAKAAKELNGLNVDGRPMKIEVVFDASFAPPVVPPKSLADRVAHKPQPKPATAPKAATNKPKARGTRGSGRGARGRNPGRGKPKTVEELDAEMVDYFNNDGTAAESSAPVNGVAAPVAAGEDTGMAEISVSRPYLSCDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCN1</accession>
    <name>A0A9W9XCN1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003621</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat cdt2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790764.1">
        <property type="nucleotide sequence ID" value="XM_056933223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCN1"/>
    <dbReference type="GeneID" id="81623472"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051865">
        <property type="entry name" value="WD-repeat_CDT2_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852:SF0">
        <property type="entry name" value="DENTICLELESS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852">
        <property type="entry name" value="LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="331"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="655"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5488731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="721" mass="79090" checksum="3F5230327D1D2F5B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCT5</accession>
    <name>A0A9W9XCT5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-tyrosine-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_003817</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790960.1">
        <property type="nucleotide sequence ID" value="XM_056933419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCT5"/>
    <dbReference type="GeneID" id="81623668"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14516">
        <property type="entry name" value="DSP_fungal_PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000110">
        <property type="entry name" value="PPS1p Protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053239">
        <property type="entry name" value="Dual_spec_PTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047949">
        <property type="entry name" value="PPS1_DSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47550">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47550:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="505"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="573"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5488927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="683" mass="76774" checksum="4427CBB2A7C184B9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCX7</accession>
    <name>A0A9W9XCX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_003980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791123.1">
        <property type="nucleotide sequence ID" value="XM_056933582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCX7"/>
    <dbReference type="GeneID" id="81623831"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="31"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5489090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="299" mass="32859" checksum="332A8C98594D9737" modified="2023-11-08" version="1">MSTSTKASTGVNHDNLRHVVITSTCFAFILSTTAVIWEWGISIAGIVLLYNGLGTHIEYVKPEQLVTLFTGSILYTLCVASIKLSTLMLYKRLFPVKSMRTAVQVVSLIIILWAACGILAGCFLCIPTDKLWNPMIPGGCMDLAKFYYGLQIPNIVTDAIILVMPMHIVWSLPISKAQKTGLSIIFILGLLTLIFDIIRLVALVDLSKAGNDITYTQVNSSVWTCIEPAVGIVAACLTNMRPLFKLAREKVWMRHAGSAANSSQQEIVGENGEKRWTRDMSNHTSSTCQSQSPRFDSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCZ3</accession>
    <name>A0A9W9XCZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Actin-related protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_003801</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790944.1">
        <property type="nucleotide sequence ID" value="XM_056933403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCZ3"/>
    <dbReference type="GeneID" id="81623652"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000029">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000006">
        <property type="entry name" value="Actin-related protein 3 (ARP3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5488911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="433" mass="46974" checksum="5DCF14FE1ECABADB" modified="2023-11-08" version="1">MASQTPAVVMDNGTGYSKLGFAGNDSPSFVFPTAIATKAGAGSAGSSTGSRPAVASKPTFLSGGGGGSSHLSAKRGTEDLDFFIGDEALAAGSGPGYGVNYPIRHGQIENWDHMERFWSNSIFKYLRVEPEDHYFLLTEPNRENTAEIMFESFNCAGLYIAVQAVLALAASWTSSKVTDRSLTGTVIDSGDGVTHVIPVAEGYVIGSSIKSIPIAGRDITYFVQSLLRDRGEPDSSLKTAEKVKEEYCYVSPDIVKEFARYDREPDRFLKHTVTSPNGRSISIDVGYERFLAPEIFFNPEIYSSDFLTPLPNVVDGVIQSSPIDVRRGLYKNIVLSGGSTLYKDFGRRLQRDIRHLVDARIRASEARSGGARSGGLDVAVVTHKRQRHGPWFGGSLLGQTPEFRSYCHTKAEYDEIGPSIVRRFALLGGPGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCZ8</accession>
    <name>A0A9W9XCZ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">DNA repair protein rad5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_003926</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791069.1">
        <property type="nucleotide sequence ID" value="XM_056933528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCZ8"/>
    <dbReference type="GeneID" id="81623777"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24975">
        <property type="entry name" value="UBA_Rad5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="532"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="925"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="1032"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="159"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="405"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="987"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1100"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="51"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="173"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="997"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1107"/>
            <end position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5489036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1229" mass="136929" checksum="9F976B285E4E6EBE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XD96</accession>
    <name>A0A9W9XD96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="4">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_004044</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791187.1">
        <property type="nucleotide sequence ID" value="XM_056933646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XD96"/>
    <dbReference type="GeneID" id="81623895"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="9">
        <location>
            <begin position="309"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5489154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="354" mass="39176" checksum="F587B6F815BB415A" modified="2023-11-08" version="1">MAPEGTGSDASSHRPKKLIFAPGDIDPENETSGATTQAQGQSKTLPADAVAPTAATDTTVVSKAARAHQFVTNPPLTVSQLHITDPFRQFHTWFRDPRLPASSAPETCTLATAELPSGRVSARPVYLKELDERGWVVYSNWGSREGKGAHIFGRETTAAADNRTTPDAIPEPGQDAAGGQETGNKWAALTFTWSLTERSVRIEGMLEPLRREESELYWRTRERGSQIGGWASWQSRVLWSAEPEQLATHQRQKGVTELQGSAGSMPGANVPADIDTTDIDDGRALLEQRIKEVEARFAGVEEIPLPPFWGGMRLVPESIEFWQGRRSRLHDRFRYVRIEGEGENAKWRLQRLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDA4</accession>
    <name>A0A9W9XDA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056933674.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81623923"/>
    <dbReference type="Proteomes" id="UP001148312">
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    </dbReference>
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        <property type="entry name" value="DUF3723"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12520">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="562"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="623"/>
        </location>
    </feature>
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        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="652"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="747"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="856"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1132" mass="127919" checksum="4F50D1128BE83951" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDB9</accession>
    <name>A0A9W9XDB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">N7539_004074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
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    <reference evidence="1" key="1">
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5489184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="195" mass="23148" checksum="C0E4361153943403" modified="2023-11-08" version="1">MSNDKQGKGSDSVPWDQRLRSKPQWRVWINYIKSAAVSEGVWQYMDPDLSDDEVKTLPNIEDPPTPEIVNPNVSDIADLTDKEYKRFNRYTTHSVATEHHSRLVGCRNPREKLLKLKEHFAPEEDTRREELRQAWREMIRYKPRSTVIDQWLNGWTNLYDECKAADVLDVVYRPKDPIRDFLRSTRTLDEFFYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDC2</accession>
    <name>A0A9W9XDC2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_004151</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="A0A9W9XDC2"/>
    <dbReference type="GeneID" id="81624002"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5489261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="317" mass="34513" checksum="E18333683A10E4EA" modified="2023-11-08" version="1">MSLGYGQHLIDGLYSMSKLMVVLILSPLVLYTIYLVNRYLSSRALNNGVTASFDWSKEIVLVTGGSDGIGAASVQKLAKRGTTVVVLDIRPLQYDAPKNVHYYRCDLTKESELQAVAERLRGEIGDPTCVVANAGLCRGKPLLHATPRDIELTFAVNNLALIWTAKTFLPSMVKNNHGHFLIMASQTAHLATAGIVDYAATKSAALAIYEGLQTELRHVYKAPAVRMSCLSPSAVKTKMFEGIQMPASVTLLKPSDIAEVVAETLWSGKAQNRMTPSLAYISPPTRALPDWMRVGFQDLGKDAMSALSPHHPMDEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDF2</accession>
    <name>A0A9W9XDF2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791021.1">
        <property type="nucleotide sequence ID" value="XM_056933480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDF2"/>
    <dbReference type="GeneID" id="81623729"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="246" mass="37820" checksum="82587695F74BCCDE" modified="2023-11-08" version="1">MDWICGKREWPDVVDDIKPPRAQCENLRSPKGSGIREGEFCICSYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDF8</accession>
    <name>A0A9W9XDF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutamate--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_003597</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790740.1">
        <property type="nucleotide sequence ID" value="XM_056933199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDF8"/>
    <dbReference type="GeneID" id="81623448"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000045">
        <property type="entry name" value="Glutamate--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="13">
        <location>
            <begin position="43"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class I anticodon-binding" evidence="14">
        <location>
            <begin position="519"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="570"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="576"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5488707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="595" mass="66789" checksum="BC9564E11E0C5BB9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDM5</accession>
    <name>A0A9W9XDM5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_004301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791444.1">
        <property type="nucleotide sequence ID" value="XM_056933903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDM5"/>
    <dbReference type="GeneID" id="81624152"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5489411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="75" mass="8334" checksum="3B842FA82A90290F" modified="2023-11-08" version="1">MICMTPTLAMGDELLVAIICMAIYEMVAWTQPSSWLHHYRGLAQLTSLRGPRRHQSGVALVLLPTLRSCIVSVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDQ1</accession>
    <name>A0A9W9XDQ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glucanase</fullName>
            <ecNumber evidence="14">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_004221</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 6 (cellulase B) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="14"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791364.1">
        <property type="nucleotide sequence ID" value="XM_056933823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDQ1"/>
    <dbReference type="GeneID" id="81624072"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.40:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="entry name" value="1, 4-beta cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876:SF4">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14" id="KW-0624">Polysaccharide degradation</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
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            <begin position="19"/>
            <end position="463"/>
        </location>
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            <end position="54"/>
        </location>
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        </location>
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        </location>
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        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="463" mass="48430" checksum="0626BF455B8E7CC2" modified="2023-11-08" version="1">MQRTSAWALLLLAQIATAQQTIWGQCGGSGYSGPTACPAQATCSTQNPYYAQCIPGSGNGGGGATTTTTTAGQTTRTTMATTTTKATTTSAGGSGGSTTTAPPSKGNPFAGYQPYANPYYSSEVVSLAIPSLPASLAPKASAVAKVPSFVWLDTAAKVPTMGTYLADIEAKNKAGANPPIAGIFVVYDLPDRDCAALASNGEYSIANDGVAKYKAYIDSIRTLLVKYSDVHTILVIEPDSLANLVTNMNVAKCANAHDAYLECVNYALKQLNLPNVSMYLDAGHAGWLGWPANLGPAATLFAKVYTDAGSPASVRGLATNVANYNAWSLDTCPSYTQGDQNCDEKRYVNALAPLLSAAGFDAHFITDTSRDGVQPTKQQAWGDWCNVIGTGFGMPFTTDTGDALEDAFIWVKPGGESDGTSDSSATRYDAHCGYSDALKPAPEAGTWFQAYFEQLLVNANPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE60</accession>
    <name>A0A9W9XE60_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">N7539_004600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5489710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BOX TRANSCRIPTIONAL REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10820)-RELATED"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
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        <location>
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            <end position="219"/>
        </location>
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        </location>
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            <end position="381"/>
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    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="134"/>
        </location>
    </feature>
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        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="617"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5489710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="784" mass="85767" checksum="6ACE0BA9992DA715" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEY4</accession>
    <name>A0A9W9XEY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">External NADH-ubiquinone oxidoreductase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_004377</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791520.1">
        <property type="nucleotide sequence ID" value="XM_056933979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEY4"/>
    <dbReference type="GeneID" id="81624228"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000002">
        <property type="entry name" value="External alternative NAD(P)H-ubiquinone oxidoreductase B1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000005">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 64 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF50">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="533"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5489487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="689" mass="76748" checksum="72D314C07C4ED875" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFN4</accession>
    <name>A0A9W9XFN4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_002896</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056932499.1"/>
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    <dbReference type="GeneID" id="81622748"/>
    <dbReference type="Proteomes" id="UP001148312">
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    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
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    <dbReference type="InterPro" id="IPR040122">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="382"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5491329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="977" mass="109479" checksum="DCE314F0601C6D8E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFR8</accession>
    <name>A0A9W9XFR8_9EURO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="3 4">
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056932496.1"/>
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    <dbReference type="Proteomes" id="UP001148312">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="77"/>
            <end position="98"/>
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        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5491326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="125" mass="13555" checksum="FE817CE78D4719AE" modified="2023-11-08" version="1">MDNVDNVQRAPKSRVKVVRSQRRMPGGLLSEKKGKISMGADATPGRKEDSLPIMMMHDEGDRVGLGKGAMEPPTTGAAVAGVFGSWAMTAVLLLMLLLPSYLTKHYLRGTQPQQDQYNLVDEVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFW9</accession>
    <name>A0A9W9XFW9_9EURO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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    <reference evidence="1" key="1">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792593.1">
        <property type="nucleotide sequence ID" value="XM_056932634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFW9"/>
    <dbReference type="GeneID" id="81622883"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5491464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="82" mass="8397" checksum="4F881732F2397E45" modified="2023-11-08" version="1">MKTRIHLTTTCQVPDIEVSGDELWDKTSGGCYVSDDYVKTGTSGGGSSSGSGYGSGAAIVGAPEKEKDLSYACGGARLCRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG52</accession>
    <name>A0A9W9XG52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792783.1">
        <property type="nucleotide sequence ID" value="XM_056932824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG52"/>
    <dbReference type="GeneID" id="81623073"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="5"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="247" mass="27293" checksum="71D5A2C6ECDD441D" modified="2023-11-08" version="1">MPTQHRILSLVYNEFEALDLFGPLGAIVPRSDYYTLELVNLHNLDSPRGIETSMKNGIGVLPTLSLAEALREDQHFDTLFIPGGFGMMPLVWDPILLQRIGQLVDRAPNVFTVCTGSILLAATGRLDGRKATTNKRLYDELTPKHPGINWQKRARWVQDGKFLTSSGVTAGIDAGFAFMANTYVAPEDRSQDVQTPSAKGDECPIPGFKNEKALKFAHFTAFGLEYRWHSDPEDDPFVDLPGTNGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGU3</accession>
    <name>A0A9W9XGU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_001483</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NDUFAF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793117.1">
        <property type="nucleotide sequence ID" value="XM_056931086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGU3"/>
    <dbReference type="GeneID" id="81621335"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05125">
        <property type="entry name" value="Mth938_2P1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1230.10:FF:000005">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone]alpha subcomplex assembly factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034095">
        <property type="entry name" value="NDUF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5492737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="240" mass="25941" checksum="3DF758E7516F98B0" modified="2023-11-08" version="1">MHSPSTQLLRALRTSLVSAHSRNSLRGAVRRSPIAVTTFKTPSSVRNNSSKIQPVRMVPRSHTHKPTSYDRGPESQEDTVTDFGALDVLGNTPVPSTAIDACLDSGFHLNSGVKITGGDALLLVGGEAFAWRPWRAVEGAENEQIAKASMINAKGQFELDEQVWGLLSLVWPRPDMLILGMGAGIYPLSPETKRHINSLGIRVDVQDTRNAAAQFNLLATERGVSEIAAALIPIGWKGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGV8</accession>
    <name>A0A9W9XGV8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_001498</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793132.1">
        <property type="nucleotide sequence ID" value="XM_056931101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGV8"/>
    <dbReference type="GeneID" id="81621350"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF238">
        <property type="entry name" value="MYB-LIKE TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="30"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="30"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5492752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="140" mass="15507" checksum="E92F5A95A468D95D" modified="2023-11-08" version="1">MMTAPTPSTSGAAEADATAPAPPTEPAPKKKGRTNTPWTAEEEQRLKTMRDAGRSWSEIAKTFPTRTEGSVKKHWYKDMHYAEFAEDESVKLRDAIKEYDANKWKVIGQKVGKPAKVGQIPTAPRPVISTMLTVIFFTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGX3</accession>
    <name>A0A9W9XGX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_001389</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793023.1">
        <property type="nucleotide sequence ID" value="XM_056930992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGX3"/>
    <dbReference type="GeneID" id="81621241"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01011">
        <property type="entry name" value="nicotinamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="8">
        <location>
            <begin position="14"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5492643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="234" mass="25436" checksum="D382B9A8A47A9414" modified="2023-11-08" version="1">MEFRGSDRGPFVPALIVVDMQEDFCPPEGSLAVREGRDIAPVINTLLAQPGLVVRIATQDWHPANHISFASNHPPPNNRPFESFAEMKNPAPDKKMESMSVQLWPDHCVANTTGSNMIPEIDTTPIDHFIRKGTDPQVEMYSAFGDAFGNLDPAVTSQSGVTDVIVVGLAGDYCVKWTAIDAVKAGFRSWLVEEGTRCVAPEGWDKVKAELHGAGVSVVHMDDPIVKKLSTAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHF8</accession>
    <name>A0A9W9XHF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Basic proline-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793432.1">
        <property type="nucleotide sequence ID" value="XM_056931401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHF8"/>
    <dbReference type="GeneID" id="81621650"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="34802" checksum="D1F1DADFEF65DB63" modified="2023-11-08" version="1">MVGSHGLEIRGASEPSNTKGATASVSESHSERAVKEDVMITSSLPREQLTPVRTRAPLAPSHLRSRSLAGIPGMPSMTRAYSSPGMDSRGRYIFVNGRGGSATQPTIDHTKRSNPGQMRSEDHLETRLGSLNIVSETISENAELETVPRSPSSQSASSPVLMPQTFLRSGRLRSTSPLHFQLPHINSPPSVHSSPTLGGRYNEAYPIHPASSTSSIPSTPTSFRSRSPSISSLETIPDIPDAEAEALEEERIAELKAAADAADAAGTTGRRRGASDVATPYNSFTLTRGGNNSYASRIDKRKRWSVCGAERRQDLDLETIWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHR5</accession>
    <name>A0A9W9XHR5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_001601</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793235.1">
        <property type="nucleotide sequence ID" value="XM_056931204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHR5"/>
    <dbReference type="GeneID" id="81621453"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5492855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="625" mass="68732" checksum="3E261DD6A5C54B61" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHR6</accession>
    <name>A0A9W9XHR6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_001982</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793616.1">
        <property type="nucleotide sequence ID" value="XM_056931585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHR6"/>
    <dbReference type="GeneID" id="81621834"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000223">
        <property type="entry name" value="Lipase/serine esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF65">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="5">
        <location>
            <begin position="6"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5493236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="457" mass="51611" checksum="0BFE5A68E4F21978" modified="2023-11-08" version="1">MSTEPKKADHLCVLVHGLWGNASHLDYVASAVKERYDEDSVYVHCAQNNSGHWTYDGVEVGGERLVHEIEETLDRLDQKGYQIKKLSIVGYSFGGLVSRYAIGLLHASGWLDKLEPVNFTTFATPHVGARTPLKGTLGDIYNTLGSKTVSRSGQQMFMVDTFRDTGRPLLSLLADPSSIFIQGLKRFRNRSVYANIVNDRTVLFYTSAISKTNPFEDPEKVRINYAKGYDDVIIDLDNYLLPDKPKQSDAAEPSQFWKRIKKNAYQVPLWIVVALVVPPAITIFFANAAVQTFRSQRRIRLHSEGKNGLRFGRYKVPLVVQNVQHVMEEAYETVGAHQEPDYLSATEEDERSKSAVPEQQTKFEGQDRSGSDSALDEESSGDAHEGKHLLGHQPTLALTEDQFGIVDSLNEVGFRKYCVYIHNHRHSHAAIIVRSRKDGFNEGKMVMKHWLDHEFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHV6</accession>
    <name>A0A9W9XHV6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_001661</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793295.1">
        <property type="nucleotide sequence ID" value="XM_056931264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHV6"/>
    <dbReference type="GeneID" id="81621513"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041000750" description="CFEM domain-containing protein" evidence="10">
        <location>
            <begin position="19"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="11">
        <location>
            <begin position="749"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="223"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="335"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="550"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="405"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="453"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="565"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="599"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5492915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="982" mass="94605" checksum="91F197D8B08A7E96" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI17</accession>
    <name>A0A9W9XI17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino-acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_001751</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793385.1">
        <property type="nucleotide sequence ID" value="XM_056931354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XI17"/>
    <dbReference type="GeneID" id="81621603"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF10">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="529"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5493005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="556" mass="60096" checksum="0E9056B4D8DEF208" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI34</accession>
    <name>A0A9W9XI34_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793796.1">
        <property type="nucleotide sequence ID" value="XM_056931765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XI34"/>
    <dbReference type="GeneID" id="81622014"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5493416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="111" mass="12971" checksum="5544C830717FB5CD" modified="2023-11-08" version="1">MSANNNEKDPIKDTTWFLINCIMSTPSRKLDKINWNEFSEKMGFKNECASYNRYKRLLNSYGLTLNYTKRDKDSDTPEANNHGTPKFNRASKKRKRPAAEPQRDTEPGDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI45</accession>
    <name>A0A9W9XI45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793699.1">
        <property type="nucleotide sequence ID" value="XM_056931668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XI45"/>
    <dbReference type="GeneID" id="81621917"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF81">
        <property type="entry name" value="ER-DERIVED VESICLES PROTEIN ERV41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="7">
        <location>
            <begin position="23"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="6">
        <location>
            <begin position="184"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5493319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="396" mass="45210" checksum="588D9ABFB6D87975" modified="2023-11-08" version="1">MNGYEPKGLDEDAFGDKGTQSGLKTFDAFPKTKASYTTPTTRGGQWTVLILAICTLLSFNELRTWWRGTEQHQFSVERGVSHELQLNLDMVIHMPCDTLRVNIQDAAGDRILAGDLLQREETSWKLWMDKRNHGSHEYQTLNHEEADRLSAQEADAHAHHVIGEVRRNPRRKFPKGPRMRWGEKADACRIYGSLEGNKVQGDFHITARGHGYRELGEHLSHEVFRTPVFNFSHMITELSFGPHYPNLMNPLDKTIAETENHYQKFQYFLSVVPTLYTKGRSAFDAYTRDPSSLAVRKNRNAIFTNQYAATSQSTPIPETPYLIPGIFFKYNIEPIMLLVSEERTGFLTLLIRVINTISGVLVTGGWVYQISGWVGEFMGKRRRQSEGVLTGKHFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIT3</accession>
    <name>A0A9W9XIT3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_002071</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793705.1">
        <property type="nucleotide sequence ID" value="XM_056931674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIT3"/>
    <dbReference type="GeneID" id="81621923"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF57">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="128"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="225"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5493325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="35869" checksum="FE2D205E6593A627" modified="2023-11-08" version="1">MTSAPAPLNMVPAPAMTQCDNIQGPGIGGNGTGTVGHPFDTVKVRLQTSPDAHFKGPLDCTLQTIRNEGVRGLYKGASPPLVGWMMMDSIMLGSLTFYKRLLLENVFSKPELRRWMPFASYQTDLATLPSFGHGIAGIMAGTTVSFIAAPVEHIKARLQVQYAADKSQRMYAGPIDCLRKLLRTHGIRGVYRGLFATMFFRSFFFFWWGSYDLLTRYMTNHTNMSAPLVNFWAGGISAQVFWLTSYPSDVVKQRLMTDPMGGSLNDGQRQFHRWRDAAQAVWRERGMRGYWRGFVPCFLRAFPANAMALVAFEGVMRTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIU9</accession>
    <name>A0A9W9XIU9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793790.1">
        <property type="nucleotide sequence ID" value="XM_056931759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIU9"/>
    <dbReference type="GeneID" id="81622008"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="191" mass="21070" checksum="1769B6325F079E27" modified="2023-11-08" version="1">MHWTAAADQIVRAQFVSLQDILIPANVLAIEQLLIKLLETHPMVIDNAAIAAAWPVGFPYGEEEAPTAKAIQDRISKIRVATRKPGGFDFSKLVAPARSSKDEVTKIVAHPRTRKQTLSAADHKVKVEDTGDDFLFRPHKTMTTDQLRMKLEDTGDNILSQLPEEVSVEAKDISRSMKSLGNDQTDDEGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIY1</accession>
    <name>A0A9W9XIY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_002201</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793835.1">
        <property type="nucleotide sequence ID" value="XM_056931804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIY1"/>
    <dbReference type="GeneID" id="81622053"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039730">
        <property type="entry name" value="Jlp2/Ccd25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049">
        <property type="entry name" value="DUF814-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5493455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="223" mass="26325" checksum="DA12DCC50E9A86DA" modified="2023-11-08" version="1">MVYYFTSNVVSPSAFIYVGKDKFENEDLIKFGLDHDVCVLMRPRDNSRFHVDNLSSAHVYLRMREGETWDNIPEPLLEDCAQLTKANSIEGNKKDNVTIIYTPWSNLQKDGSMATGQVSFHNPKLVKKVLVRVRENPIVNRLNKTRVEKFPDLRAEKEEYSKKKSRDERKTREQQQIKEKQEKREREQLKWQKDHAYDDMFSADNIEASSNQDRDPDFLDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XJ02</accession>
    <name>A0A9W9XJ02_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_002231</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793865.1">
        <property type="nucleotide sequence ID" value="XM_056931834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XJ02"/>
    <dbReference type="GeneID" id="81622083"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF43">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="288"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5493485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="743" mass="81975" checksum="A122B995A874BC52" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLA2</accession>
    <name>A0A9W9XLA2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide-bindingalpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_000084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793981.1">
        <property type="nucleotide sequence ID" value="XM_056929688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLA2"/>
    <dbReference type="GeneID" id="81619937"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12411">
        <property type="entry name" value="RRM_ist3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045844">
        <property type="entry name" value="RRM_Ist3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5494968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="309" mass="36655" checksum="DCBD17598280046C" modified="2023-11-08" version="1">MNAIRQTQALNKRELENAVPPEASWHADYRDTAYIYIGGLPLDLSEGDIITIFSQYGEPVHINLLRDKETGKSRGFAFLKYEDQRSTDLAVDNLGGATVLGRMLRVDHARYKRRDDEEEGDNVARLMGDPTTSQSKDDGNDDRHGRKGPRDNETKEARPMLKEERELQDLIQNHDDEDPMKEFLIEEKKEEVALALANYRESKRSSHRRDDSRDRSSRHHRHHRRHRSRSAEHRHRRDRSRSKEKRPRRRSAEREPESRKDSTAEHDERHRRTRTGREDQSRGEHSVERSRSSRSRRNRSERDRHDHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLC4</accession>
    <name>A0A9W9XLC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794102.1">
        <property type="nucleotide sequence ID" value="XM_056929809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLC4"/>
    <dbReference type="GeneID" id="81620058"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000021">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000015">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="288"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="784"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="852"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1130" mass="126107" checksum="4F6DC187FFE4F411" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLD1</accession>
    <name>A0A9W9XLD1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_000268</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794165.1">
        <property type="nucleotide sequence ID" value="XM_056929872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLD1"/>
    <dbReference type="GeneID" id="81620121"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_bS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5495152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="104" mass="11761" checksum="A47A2592C791DAEB" modified="2023-11-08" version="1">MVLRIRLARFGNKHTPFYNIVVAQARSARGAKPLEVIGTYNPIPKRPTNLYDENAQARPYKEVALDRARAQYWLGVGAQPSDPVWKLMTMAGLVEPKPTTFHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMN8</accession>
    <name>A0A9W9XMN8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_000491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794388.1">
        <property type="nucleotide sequence ID" value="XM_056930095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMN8"/>
    <dbReference type="GeneID" id="81620344"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5495375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="75" mass="8736" checksum="845B40321327E9A7" modified="2023-11-08" version="1">MARRRGGWMEMEIEGTELRDSLGETWCFRWRRRQGDSQQEDRERRFPVLVTGGHEAALGADSAVCAWAYAEYRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMS6</accession>
    <name>A0A9W9XMS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794901.1">
        <property type="nucleotide sequence ID" value="XM_056930608.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81620857"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009374">
        <property type="term" value="F:biotin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052572">
        <property type="term" value="P:response to host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005468">
        <property type="entry name" value="Avidin/str"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002989">
        <property type="entry name" value="Mycobac_pentapep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46766">
        <property type="entry name" value="GLUTAMINE-RICH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46766:SF1">
        <property type="entry name" value="GLUTAMINE-RICH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01469">
        <property type="entry name" value="Pentapeptide_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51326">
        <property type="entry name" value="AVIDIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040763184" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1139"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1160"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1281"/>
            <end position="1293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1636" mass="152277" checksum="1E25F0EE0AC1F55D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN00</accession>
    <name>A0A9W9XN00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_001077</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794974.1">
        <property type="nucleotide sequence ID" value="XM_056930681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN00"/>
    <dbReference type="GeneID" id="81620930"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF165">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="52"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5495961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="378" mass="41376" checksum="D13F9030F264B909" modified="2023-11-08" version="1">MTKSAIVSYGGKGPLVLGVTWAETTLALVLFFLRARTASVCPQGQLSSGFFGLRWDFVWAILAFAGALAAQCTMTVSVHYGLGNHQNLLSYDNIVKTNLWSWIAQILAIIDLVIARIAVIAFLMTIQNRTQSKSKYLLYGVGSAQAIINFIEIGLIFKQCTPTRKLWDIDVPGKCDMIEICSKVGFVQGTSSSGIGAAADFFLAAYPVYIIGRLQLMKLSTKIGLCLIMGGGLVAGIAGINKTLAIASITHVDDLTYAIYELNTWVLTEMWFIIIFGSIPVLRPFFVRFTQDIKSVTGNSSRNRSNAEAYSEGSRNKRESLVQLTEHVPGTWASHNSMSADASHDPMHSLGIEIPQEDCGYIMVTKDTMVVSEHGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XNU6</accession>
    <name>A0A9W9XNU6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="6">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_001121</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Vacuole membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795018.1">
        <property type="nucleotide sequence ID" value="XM_056930725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XNU6"/>
    <dbReference type="GeneID" id="81620974"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="7">
        <location>
            <begin position="144"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="9">
        <location>
            <begin position="377"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5496005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="504" mass="56291" checksum="C7260F315A5CCBA8" modified="2023-11-08" version="1">MADFVDPRMTSIKPRIRYNTIGGINGPLVFLDNVKFPRYNEIVSLTLPDGTERSGQVLEARGSRAVVQVFEGTSGIDVKKTKVEFSGHSLKLGVSEDMLGRVFDGSGRAIDKGPKVLAEDYLDINGQPINPYSRVYPEEMISTGISAIDTMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKRPTKDVHDGHEENFSIVFAAMGVNMETARFFTRDFEENGSMERVTLFLNLANDPTIERIITPRLALTTAEYYAYQLEKHVLVIMTDLSAYCDALREVSAAREEVPGRRGYPGYMYTDLSTIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIFVDRQLANKGVYPPINVLPSLSRLMKSAIGEGRTRKDHSDVSNQLYAKYAIGRDAAAMKAVVGEEALSSEDRLSLEFLDKFERTFISQSPYESRTIQESLDIAWNLLRVYPKELLNRIPKRVLDEFYARSARKIANKDTRDNSGEQQQSDNLIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XNV6</accession>
    <name>A0A9W9XNV6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794903.1">
        <property type="nucleotide sequence ID" value="XM_056930610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XNV6"/>
    <dbReference type="GeneID" id="81620859"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF1">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="36397" checksum="89565AE07FF77D00" modified="2023-11-08" version="1">MTSLADVPGSTAHKIFLHSRRPSLFSSRGHDRLRNPSRCVEQGSHPTHPRVDSLEDHLPPPFIPLGGVSNFRDLSYENNLRPGYVYRSANLSDITDDGKRMLADELGVTTIFDLRNESERVKAPAPRIDEIETVWEPYGGKPASLSLRDFAGNDHGVRGFVQMYSGILEASAPAFGHVFLHIRDQPHDPFVFHCSAPSGPVGSAFDQRSETFLTDCVSFTAGKDRTGVLAALILSLMGRPHQEIIEDYILTRAGLECVRENLAQALDLDEGTDHLSPEAIGMLELSGVRAPAMAAFLKHLESTYGSGAEGYLTKKLGFTSIDIQKMVKNLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ02</accession>
    <name>A0A9X0BJ02_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785661.1">
        <property type="nucleotide sequence ID" value="XM_056939166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJ02"/>
    <dbReference type="GeneID" id="81629416"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700">
        <property type="entry name" value="YALI0E22418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5466615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="789" mass="86354" checksum="7B08BEE809480A45" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJC5</accession>
    <name>A0A9X0BJC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_009064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786036.1">
        <property type="nucleotide sequence ID" value="XM_056938659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJC5"/>
    <dbReference type="GeneID" id="81628909"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000070">
        <property type="entry name" value="Related to MRF1-peptide chain release factor, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="4">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5469446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="422" mass="46987" checksum="5EAA3204CA078E35" modified="2023-11-08" version="1">MLQCSRLFWRPARRVLGRALHPLHSAASDSGLSPVLLTRARLLADEHTKLSDKIAETFDAKIAKRVGEIAPVTQVLREWDSANESITELESLLEQPETDDELRSLAIEDLQTSHESLPIISDRLKKALIPRHPFADLPCLVEIRPGAGGDEAGLFAFELMRMYTSFCSRRGLRPTILKQDVEDGASEDRLTEAVIEIEADGAYDILRTESGVHRVQRVPATETKGRTHTSAVSVMVLPSFPESGSGSADNALNFEDPTSDYYIDPQEVRVEKMRASGAGGQHVNKTESAIRLTHIPTGTVVSMQDERSQHSNRRRAWQVLRAKIAEIRQEAREQELMQLRRGAMGGVARMGRGDKIRTYNFGQSRCTDHRSGITIHNLDGVLDGGDGLETVMESVRTWMADRDVEGMLAEEMAKAELEQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJS6</accession>
    <name>A0A9X0BJS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_009261</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786233.1">
        <property type="nucleotide sequence ID" value="XM_056938856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJS6"/>
    <dbReference type="GeneID" id="81629106"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5469643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="207" mass="22806" checksum="4CAC04F2D51709A3" modified="2023-11-08" version="1">MQSPFHYSSYASSPGEMDFYYGPTQPIYDQPFGDLDTTTSFAIPEFMNGTPNSFTSAPYTFSSGFEIAPGYETPMATSGPGSDSSACGSVYGGSNWNPTAEELLPMPSYPLLSDDSGPDSPPSQNKPTKPFGCDHCGKSFTRFADLKRHSTSVHYPVFRDCPVEHCSRKGSNGFPRQDHLKEHLRSYHHLDVPKRRAVKRSAKTAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BLN4</accession>
    <name>A0A9X0BLN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786436.1">
        <property type="nucleotide sequence ID" value="XM_056938428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BLN4"/>
    <dbReference type="GeneID" id="81628678"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="82" mass="9193" checksum="96C35737F37DEAAF" modified="2023-11-08" version="1">MTRPMRIQESFGSMGYVNQNGAQPYAALSHPDYIRTGTTCASRSKIPFRVDHGPAILTKTAQLTKQHERPSYKQQRKIASSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BN87</accession>
    <name>A0A9X0BN87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uroporphyrinogen-III C-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_007737</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Siroheme synthase involved in methionine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>uroporphyrinogen III + 2 S-adenosyl-L-methionine = precorrin-2 + 2 S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32459"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787203.1">
        <property type="nucleotide sequence ID" value="XM_056937338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BN87"/>
    <dbReference type="GeneID" id="81627587"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000006">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000005">
        <property type="entry name" value="Uroporphyrin-III c-methyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012066">
        <property type="entry name" value="Met1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF6">
        <property type="entry name" value="UROPORPHYRINOGEN-III C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036555">
        <property type="entry name" value="SUMT_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="2 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="15">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="14">
        <location>
            <begin position="250"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="13">
        <location>
            <begin position="313"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5475450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="590" mass="64123" checksum="7FC22EB396BB3B3F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNM3</accession>
    <name>A0A9X0BNM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NEDD8-conjugating enzyme UBC12</fullName>
            <ecNumber evidence="11">2.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NEDD8-conjugating enzyme Ubc12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">RUB1-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin carrier protein 12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">N7539_007981</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34" evidence="11"/>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787447.1">
        <property type="nucleotide sequence ID" value="XM_056937582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNM3"/>
    <dbReference type="GeneID" id="81627831"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000005">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 17" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="18">
        <location>
            <begin position="30"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="16">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ5475694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="184" mass="20839" checksum="237559BE1A374D8F" modified="2023-11-08" version="1">MLKIWSMKQQQAQAENAESAAGNKKKKVTAAQLRVQRDLQELTLGNTMKMSFPNPDDILNFTLSIEPDEGMYKGGVFNFNFTVNQNFPHDPPKVKCTQKIYHPNIDLDGNVCLNILREDWKPVLNLNAVIVGMQFLFLEPNASDPLNKEAADDLRNNREAFKRNVRSSMAGGAVRGETFERVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSF3</accession>
    <name>A0A9X0BSF3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_006964</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788500.1">
        <property type="nucleotide sequence ID" value="XM_056936565.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81626814"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055781">
        <property type="entry name" value="DUF7357"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056398">
        <property type="entry name" value="Tudor_Coilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711:SF1">
        <property type="entry name" value="ECTODERMAL, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24054">
        <property type="entry name" value="DUF7357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23086">
        <property type="entry name" value="Tudor_Coilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7357" evidence="3">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Coilin tudor" evidence="2">
        <location>
            <begin position="762"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="768"/>
        </location>
    </feature>
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        </source>
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            <dbReference type="Pfam" id="PF24054"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="KAJ5481070.1"/>
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            <dbReference type="Proteomes" id="UP001148312"/>
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    <sequence length="1300" mass="142180" checksum="E62B379383195E72" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BT07</accession>
    <name>A0A9X0BT07_9EURO</name>
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        <submittedName>
            <fullName evidence="10">Major facilitator superfamily multidrug transporter mdrA</fullName>
        </submittedName>
    </protein>
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        <name evidence="10" type="ORF">N7539_006528</name>
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        <name type="scientific">Penicillium diatomitis</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="10" key="1">
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                <person name="Petersen C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
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            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
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            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="158"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="222"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="247"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="74"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5483082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="613" mass="67156" checksum="4F66763CD92DFF71" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BTE0</accession>
    <name>A0A9X0BTE0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_006455</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788981.1">
        <property type="nucleotide sequence ID" value="XM_056936057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BTE0"/>
    <dbReference type="GeneID" id="81626306"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000095">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040807273" description="chitinase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="12">
        <location>
            <begin position="38"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5483009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="429" mass="46810" checksum="84BA7A1D20956C9E" modified="2023-11-08" version="1">MRFFLPLVLGLAWLVEGAVIPSHHINGTELEARASAGYRSVAYFVNWAIYGRNFNPQDLPAERLTHVLYAFANVHPDTGEVYLSDSWADTDKHYPGDSWSETGNNVYGCVKQLFLLKQRNRKLKVLLSIGGWTYSSNFAAPLSTASGRATFASSATDLVKNLGFDGVDIDWEYPANSAQADNMVSTLQQLRSSLDTYSAANANNYHFEITVACPAGPSNYQQLHMAQMDKYLDFWNLMAYDYSGSWDTIAGHDANTFASTSNPASTPFNTDQAISYYTANGVAANKIVMGMPLYGRSFMSTDGPGKPFSGVGSGSWENGVWDYKALPLTGASVNFLSQEIASYSYDSAQRMMVSYDTPQVAQLKAQYIQSKGLGGGMWWESSSDKTGSDSLITTVVNQFGGVGALDQSPNQLSYPVSSYDNLKAGFPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BTU1</accession>
    <name>A0A9X0BTU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="6">5.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_005794</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789268.1">
        <property type="nucleotide sequence ID" value="XM_056935396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BTU1"/>
    <dbReference type="GeneID" id="81625645"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000069">
        <property type="entry name" value="Inositol-3-phosphate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000204">
        <property type="entry name" value="Inositol-3-phosphate synthase 1-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0398">Inositol biosynthesis</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="16">
        <location>
            <begin position="328"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5483998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="531" mass="58216" checksum="80A612605871B7A6" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUK9</accession>
    <name>A0A9X0BUK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Drug/proton antiporter YHK8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_004954</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789750.1">
        <property type="nucleotide sequence ID" value="XM_056934556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUK9"/>
    <dbReference type="GeneID" id="81624805"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000063">
        <property type="entry name" value="MFS multidrug transporter, putative (AFU_orthologue AFUA_2G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF7">
        <property type="entry name" value="DRUG_PROTON ANTIPORTER YHK8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="133"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5484966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="578" mass="65579" checksum="B477464E9B46C823" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUV6</accession>
    <name>A0A9X0BUV6_9EURO</name>
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        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_005315</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790111.1">
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    </dbReference>
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    <dbReference type="GeneID" id="81625166"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="COP9_N"/>
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    </dbReference>
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        <property type="entry name" value="PCI_dom"/>
    </dbReference>
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        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
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        <location>
            <begin position="245"/>
            <end position="416"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014878"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5485327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="499" mass="55391" checksum="EE7F1C344BC8EE6F" modified="2023-11-08" version="1">MSVLEGLRAQSAQLHEALRNTDAAYDQQIRQHVASLREAVSAKYLGDLARDESLLDHIDPTADSLLYLYILRAQIEIFQEESRQSLPAVLLPTGWLWPKIVSYLKSFNPVQSRYVGEEWRQVVELVAQIAQASSQPLLAARVIRDAMLRLDPSCTVLTSTHLVLVRLCLRARAYSCALPVLDKYVCHFPSSQPGAGAGFAPFLCASHDSSLSFVTEKSGLSAKLTYKDHLQYYLYGGMIYMALKQWTKAIHFLQIVISMPTTGSVSMIMVEAYKKWILANLLEKGKLPSTTNLMVTSHSRVYQSLAKPYVSLAQAFESGDLKRIEEEIEAARDVWRADHNLGLVSQVHCAYIKHMVERVKKTFAALTVDELLRQSPSMQVSNQVTESTIASLIMSGAVSATLVQPSDPTKSTMVRFTESRSSIRLVHEREVQLSLAREGQALRTLSKSLGDLDSQLGLSNEVIDSLKRSQAWTAVGEPRPGTSEDAGVDMDEDLMGEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXG7</accession>
    <name>A0A9X0BXG7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003676</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790819.1">
        <property type="nucleotide sequence ID" value="XM_056933278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXG7"/>
    <dbReference type="GeneID" id="81623527"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF57">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
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        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
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        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
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        <location>
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            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="571"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5488786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="603" mass="64917" checksum="FDFF8DB1B5C24C0E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXU2</accession>
    <name>A0A9X0BXU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_003407</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790550.1">
        <property type="nucleotide sequence ID" value="XM_056933009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXU2"/>
    <dbReference type="GeneID" id="81623258"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF4">
        <property type="entry name" value="MEMBRANE CHANNEL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="535"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="112"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="351"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="888"/>
        </location>
    </feature>
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        <location>
            <begin position="1056"/>
            <end position="1114"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
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        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="784"/>
        </location>
    </feature>
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        <location>
            <begin position="821"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="848"/>
        </location>
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        <location>
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            <end position="872"/>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="1076"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1092"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5488517.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1114" mass="126099" checksum="99B9F99F8B37B256" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY63</accession>
    <name>A0A9X0BY63_9EURO</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">N7539_004084</name>
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        <name type="scientific">Penicillium diatomitis</name>
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    <reference evidence="2" key="1">
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            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791227.1">
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    <dbReference type="AlphaFoldDB" id="A0A9X0BY63"/>
    <dbReference type="GeneID" id="81623935"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="77" mass="8568" checksum="0B6AE75B29BF7652" modified="2023-11-08" version="1">MYQIHEKDKQVVDGAAGSWQQAAQKPFSKSWLGRGATSTETGCRLPLSQMRLGVENLGHPSHFQPGRGEAEKEEDWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY67</accession>
    <name>A0A9X0BY67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Late sexual development protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5489209.1"/>
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        <property type="nucleotide sequence ID" value="XM_056933701.1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040934934" description="Late sexual development protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="38627" checksum="7B1EB02BA1229AAA" modified="2023-11-08" version="1">MHFSDLAILSSILALPVLGVPHPQAQSHLPDGLPSPDTTQVAHIEQVAQGTLPNSPAPTAISNEGIVNLKLIAFNELFEVAFFSELVNNVTNNVDGYTFKRDEDRSSMLEALKAIVAQEELHALRANDALKHFKATQVQPCKYKFPVQNLESAIKLAATFTDVVLGTLQDVVERFARGHDFDLAREIASVIGQEGEQQGWFRALLGKIPSELPFLTTSNLNFAFNAIQDFVVPGTCPDLNEIPLHTFEPLKILDMPGPRSQNISIEFRDPDDEARNPLWVTYINQQNVPVVQPLWVVSKKDKIVEAKVLFPFEEHDLKGLTIASVTKSAGPFGDASQVANHTLAGPGLITVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY86</accession>
    <name>A0A9X0BY86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA ligase/cyclic nucleotide phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_004501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791644.1">
        <property type="nucleotide sequence ID" value="XM_056934103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BY86"/>
    <dbReference type="GeneID" id="81624352"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5489611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="312" mass="35398" checksum="D91D446FBAC40B1E" modified="2023-11-08" version="1">MANPVIYKDNPFNVLINDSHDDPTQIQARYETHRVNRNAQQREKILADDFPGWTLDTILQRLDGPAKEEGFVDPRNCLVFWARPPPHIRQVVAFVQNELKAVAPSLWLMPQPNLHTTVLEVAHSLTEPEIARLVQTLKSSEKVTQQTISDYPLTHQSRLLRPMVSFDASALALSFAPAAEENQTQSHGESSAEPLDPRYTYHHLRRDVFDLVRQTGLPVASRYIAPSAHVTIARFINQEGFEVQGQDGAKKVDSERVQMLMERIESVNATLRSKYWPREDGSCAREGEWIVGQEGGLVVRRGRLWYGDGEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYN5</accession>
    <name>A0A9X0BYN5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="9">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_004307</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RSP5/NEDD4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="9"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791450.1">
        <property type="nucleotide sequence ID" value="XM_056933909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYN5"/>
    <dbReference type="GeneID" id="81624158"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08382">
        <property type="entry name" value="C2_Smurf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000011">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000053">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000074">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="109"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="345"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="465"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="527"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="15">
        <location>
            <begin position="616"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="266"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="369"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="266"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10 11">
        <location>
            <position position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5489417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="949" mass="106106" checksum="945831F2A8FA0EA2" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYV1</accession>
    <name>A0A9X0BYV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_004517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791660.1">
        <property type="nucleotide sequence ID" value="XM_056934119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYV1"/>
    <dbReference type="GeneID" id="81624368"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5489627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="86" mass="9660" checksum="0F8A43A9AF7FEF32" modified="2023-11-08" version="1">MFVSILTNNTTTSLRAKEIIAASRNVENAPLELEFESIIRRPPAPNTNEWNITFTAKDLTACCDYAFPEALILSLSPWELNTKLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYZ4</accession>
    <name>A0A9X0BYZ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_002738</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792300.1">
        <property type="nucleotide sequence ID" value="XM_056932341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYZ4"/>
    <dbReference type="GeneID" id="81622590"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3450.20:FF:000003">
        <property type="entry name" value="Nuclear pore complex protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5491171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1046" mass="118197" checksum="10E7A386E233C0F5" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZQ6</accession>
    <name>A0A9X0BZQ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_003326</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792887.1">
        <property type="nucleotide sequence ID" value="XM_056932928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZQ6"/>
    <dbReference type="GeneID" id="81623177"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05811">
        <property type="entry name" value="CBM20_glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000552">
        <property type="entry name" value="Related to glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034836">
        <property type="entry name" value="CBM20_glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF231">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040928961" description="alpha-amylase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="15">
        <location>
            <begin position="517"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5491759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="625" mass="67348" checksum="2B7B958D9F446FE8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0A4</accession>
    <name>A0A9X0C0A4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein RO7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793275.1">
        <property type="nucleotide sequence ID" value="XM_056931244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0A4"/>
    <dbReference type="GeneID" id="81621493"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5492895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="58871" checksum="C1BD754A83D9993F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2F6</accession>
    <name>A0A9X0C2F6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor steA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_000532</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STE12 transcription factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794429.1">
        <property type="nucleotide sequence ID" value="XM_056930136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2F6"/>
    <dbReference type="GeneID" id="81620385"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990527">
        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000390">
        <property type="entry name" value="Transcription factor stea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003120">
        <property type="entry name" value="Ste12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF1">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02200">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00424">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="542"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="399"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="489"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="564"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="580"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="597"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5495416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="646" mass="71749" checksum="634A59AC831AFE7A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2G2</accession>
    <name>A0A9X0C2G2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aminotransferase swnA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_000140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794037.1">
        <property type="nucleotide sequence ID" value="XM_056929744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2G2"/>
    <dbReference type="GeneID" id="81619993"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="134"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5495024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="515" mass="57146" checksum="277CE3A059E33C61" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2G9</accession>
    <name>A0A9X0C2G9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794067.1">
        <property type="nucleotide sequence ID" value="XM_056929774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2G9"/>
    <dbReference type="GeneID" id="81620023"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF7">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="342" mass="37504" checksum="646F63BBF800C325" modified="2023-11-08" version="1">MSSIKVFLTGATGYIGGEVLYTVTNAHPDWEITTLVRTKKKADLVSSRYPNIHIVQGDLDSVELIEEQVKEADIVFNCANCDHVASAEAIARGARHHTAEHPLWLIHTSGTGILTIEDKRANTMGIERPKEYNDWEGISEMINFPADGIHREVDKIILDMGTQSPKRVHTAIVCPPAISGPGRGPVKTKSSQAYRLSAAVLTRGSGILIGKGENVWHQVHVQDLSNLFLALGDAAAECGGNATWNEEGYYFAEDGSFVWGDIQREIAKQAHLQGLINSPDVHELNAEEVNKISPTGHYAWGSNSRGHALRARKLLGWEPKMPKLIDMIPDIVALEAKDLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C383</accession>
    <name>A0A9X0C383_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_001041</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794938.1">
        <property type="nucleotide sequence ID" value="XM_056930645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C383"/>
    <dbReference type="GeneID" id="81620894"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13965">
        <property type="entry name" value="PT_UbiA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050475">
        <property type="entry name" value="Prenyltransferase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723:SF1">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5495925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="295" mass="33021" checksum="F2829E8376DD7BE2" modified="2023-11-08" version="1">MDTPWIQLLQLIWLFTESNFSTFVLPNSAFGLLTGLAAPLLTDCPERPALSQLFLRGLAVILFNWANVFVFDLANQRLPESQLEDRLNKPWRPLPTGQISPDTTRRWMLVAIPLVLTISAVLGVATQSAGIMILTWLYNDLRGGDEIVRDGIIACGYALYLSSSLRIVSGLDVQITQHGYMWIAIMGGIILTTMQVQDLKDQVGDRTRGRQTLPLVLGDKLSRGSIVCFILFWSICCCYFWHIPLWGYVVPLLTGLGVSFHVAKGTNDAKAWRLWCMWQVVIYGIPGWVAVSGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKW1</accession>
    <name>A0A9W9WKW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secondary thiamine-phosphate synthase enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785642.1">
        <property type="nucleotide sequence ID" value="XM_056939147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKW1"/>
    <dbReference type="GeneID" id="81629397"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047_YjbQ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJBQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615:SF8">
        <property type="entry name" value="UPF0047 PROTEIN C4A8.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5466596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16247" checksum="D3916CEC4858D675" modified="2023-11-08" version="1">MSWFQKTFTLPSRSRGSYLITDEVVSALPELREYKVGMLNLFVQHTSCALSLNENWDEDVRADMSDALDRIAPFDRKGDLYRHSAEGEDDMPAHIKSALIGASVNIPISNGRLATGTWQGIWHLEFRTSRHTRKVVATIQGQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL65</accession>
    <name>A0A9W9WL65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Flap endonuclease 1</fullName>
            <shortName evidence="15">FEN-1</shortName>
            <ecNumber evidence="15">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">N7539_009132</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleoplasm</location>
        </subcellularLocation>
        <text evidence="15">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="15"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786104.1">
        <property type="nucleotide sequence ID" value="XM_056938727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL65"/>
    <dbReference type="GeneID" id="81628977"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000003">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
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    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 15 19" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 15" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="17">
        <location>
            <begin position="146"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
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            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="348"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="353"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
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        </source>
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            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ5469514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="395" mass="44573" checksum="896597C7AD715D56" modified="2023-11-08" version="1">MGIKNLYQIISENAPDAIKTGEIKNHFGRKVAIDASMSIYSFLIAVRSEGQQLMSESGETTSHLMGMFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRGARKAEAAEAHEEAKETGTAEDVEKFSRRTVRVTREHNAECKKLLKLMGIPYIDAPTEAEAQCAVLARAGKVYAAASEDMDTLCFEAPILLRHLTFSEQRKEPIQEIHLNKAMEGLNMDRNQFIDLCILLGCDYLEPIPKVGPSTALALIREHGTLEKVVEYMNNDPKKKYVIPEDWPFQDARELFAHPDVRDANHPDCDFKWEAPDVEALVQFLVADKGFNEDRVRNGAARLTKNLKSAQQSRLEGFFKPVAKTDEEKTSLKRKHDEKLQEQKKRKKDEAKAKKEAKSKPRGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9W9WLJ0_9EURO</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
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            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP001148312">
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    <dbReference type="PANTHER" id="PTHR28180">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF2">
        <property type="entry name" value="PEROXISOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5469397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="280" mass="29713" checksum="AFBE49863D320ED8" modified="2023-11-08" version="1">MSKLSASLKTLINSPAARPHTVPAPPNIGHVYRTIQQTAAANKVSQPSWLALSTAATMTMNSPNSLAALYHVASNTAPNSAVSSAELMREVGLKCISFNGIPRTINCLNAFRASLPEDITSQLSTTPTRTPTAENIAGISARGRALWDSIYRPFEKKLYEKLGTSHPDLPVHILHANYGALLSDPERETGASAGRVLTSLVAVACLRAQTGVGPQVLSHVFGLRKALEDGSWASDVESEEGARWLASDEGNMWILESVDAIVEAISGGMGSNFAPARAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQM2</accession>
    <name>A0A9W9WQM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">N7539_008772</name>
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    <reference evidence="2" key="1">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786375.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQM2"/>
    <dbReference type="GeneID" id="81628617"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="98" mass="10486" checksum="3AD4DD0CAC0A5BA0" modified="2023-11-08" version="1">MQATNAEGHQRGRPPTRKATNAEGHQRGRPPTREATNAGGHQRGRPPTREATNAGRSLTWEAAKNHQTVGLQDIVYAYLAGRNIGKNWCGGGSSPSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQZ3</accession>
    <name>A0A9W9WQZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786442.1">
        <property type="nucleotide sequence ID" value="XM_056938434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQZ3"/>
    <dbReference type="GeneID" id="81628684"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="102" mass="12349" checksum="3AB5A0589FC844B1" modified="2023-11-08" version="1">MSKPTYSDAEWRRLVKMQEEIAEARRQALIASQEAMAKVMRLERHEALLRSRAGDFIARDYKEIAELEELERREKEEFERLERERLEERPCRDRCFSICWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WR90</accession>
    <name>A0A9W9WR90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786670.1">
        <property type="nucleotide sequence ID" value="XM_056938288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WR90"/>
    <dbReference type="GeneID" id="81628538"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5472124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="154" mass="16942" checksum="795FFDE2F0BB28C3" modified="2023-11-08" version="1">MRFQFGSSELSFPTAHDCPTLPALTMESSSVTALYGLLKKQLLKKQKSYERLIALLVSALSLKIGVDGLTLSAARRELIGLLLLPSFAFLYQFSTFSNAIPSSSVHLRHLAGQVTAVEPNTFDSLIESHSSTFKAGCKNYERNHGRKPPAHFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTE4</accession>
    <name>A0A9W9WTE4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N amino acid transport system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_008257</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786949.1">
        <property type="nucleotide sequence ID" value="XM_056937857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTE4"/>
    <dbReference type="GeneID" id="81628107"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF8">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="39"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5475191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="452" mass="49082" checksum="86E42B2949F30FB1" modified="2023-11-08" version="1">MSPSKTKSDKMTPSDDGVLDMSDREQQIYEGGIQKFNRLGWKRLTVVLIVEAVALGTLSIPATFAKLGMVAGVICCVGIGLIAVYTSYVIGQVKVKFPHISDYPEAGRQMFGRWGYEILYMMLALELLLSAGSHCLTGTIAFKNITESNICSVVFGVVSAIILFIFAVPPSFSEMAILGYIDFVSIIIAVGITIIGTGVEASNSTGLAAVNWSAWPKEGLTFTEAFIALSNIIFAYSFALCQFSFMDEMHTPTDFPKSIVSLGFAEIFIYTVTGALVYAFVGQDVQSPALLSAGHLLSRVAFGIALPVIFISGSINTVVLGRLIHGRVFKNSNIRFVNTKMGWTTWLALIVVLSILQFVVAEVIPFFDDLLSVISSLFVSGFTFYFPAIMWFMFIREGSMFSKKNLFFSILNAAIFVIGMVVLGAGTYASIKDIIDSYDNGSVKGVFSCTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTH6</accession>
    <name>A0A9W9WTH6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Partial AB-hydrolase lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_008256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786948.1">
        <property type="nucleotide sequence ID" value="XM_056937856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTH6"/>
    <dbReference type="GeneID" id="81628106"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000193">
        <property type="entry name" value="Ab-hydrolase associated lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="3">
        <location>
            <begin position="206"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5475190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="637" mass="72038" checksum="8DC8EBA99C3386A0" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUA0</accession>
    <name>A0A9W9WUA0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar RNA-associated protein 15 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_007895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787361.1">
        <property type="nucleotide sequence ID" value="XM_056937496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUA0"/>
    <dbReference type="GeneID" id="81627745"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000633">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit Utp15, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000867">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit Utp15, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="134"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="177"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="7">
        <location>
            <begin position="393"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5475608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="542" mass="60353" checksum="0A94524791FE3DC0" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUN9</accession>
    <name>A0A9W9WUN9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetate/butyrate--CoA ligase AAE7peroxisomal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_007204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787604.1">
        <property type="nucleotide sequence ID" value="XM_056936805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUN9"/>
    <dbReference type="GeneID" id="81627054"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859">
        <property type="entry name" value="ACYL-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859:SF4">
        <property type="entry name" value="BUTANOATE--COA LIGASE AAE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="41"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="482"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5477060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="577" mass="63786" checksum="199CFD9DA73AD847" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUZ7</accession>
    <name>A0A9W9WUZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5476987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787531.1">
        <property type="nucleotide sequence ID" value="XM_056936732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUZ7"/>
    <dbReference type="GeneID" id="81626981"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040735402" evidence="2">
        <location>
            <begin position="23"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5476987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="422" mass="47979" checksum="74FD0B832C778F55" modified="2023-11-08" version="1">MTDEVQFLLFVFIALQVQIVRHGPLPLYSLAYALGILEDPKWLVECGRRYGYGYGYEGEDRSESESEDVEVELTMEYAGTETGGDPRKLGEGDWDRTMSLHVRREDMERGGSTLESTCGEDWGGGCVDDERRSREYVLIEEGEGEVQSERGSERIADSVVVGDDVDAICETVSRAGDKMSQTQTRDEYVARQTDPTDRPIDLQVDEQQVGLDAELDPKPKYEAALQHLKSMSSWFTFRSNNHNISMSPKRIATQHRQHTDNPPFLNAYTYRPQQDQPTLPSDSHHPDSHSHKEQQSRTDHQHQHQQHTNPSTFQFTPKYQRPPPACPSSPIPDPDEALPFANYFFGRKGLQYYLDLDRDSDEDAYSPLNWVIPEYARGRSTRRSLEDIEPILDRKAKLPLGRRDAPVLTTGTRLVGLEGASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV97</accession>
    <name>A0A9W9WV97_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_008004</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787470.1">
        <property type="nucleotide sequence ID" value="XM_056937605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV97"/>
    <dbReference type="GeneID" id="81627854"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
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            <dbReference type="Proteomes" id="UP001148312"/>
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</entry>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="264"/>
        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9W9WVN3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007265</name>
    </gene>
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        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
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            <strain evidence="3">IBT 30728</strain>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Frisvad J.C."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
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            <begin position="521"/>
            <end position="531"/>
        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAJ5477121.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="745" mass="74558" checksum="D4C768B18A398608" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X216</accession>
    <name>A0A9W9X216_9EURO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">IBT 30728</strain>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056936451.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81626700"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5480956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="665" mass="73528" checksum="9D9FA02913B9F49C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X286</accession>
    <name>A0A9W9X286_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_006959</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788495.1">
        <property type="nucleotide sequence ID" value="XM_056936560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X286"/>
    <dbReference type="GeneID" id="81626809"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.480:FF:000005">
        <property type="entry name" value="Indoleamine 2,3-dioxygenase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF3">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5481065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="496" mass="56385" checksum="A77F1678509C9C30" modified="2023-11-08" version="1">MTRSQVPVPSPATLKRFPHIHDDPSNLSHALDPFTITTSTGFLPYQTAPTHLPDVFKPLESLVERLPVVKLDGTPGLLATYELGPATEKELPDLTDEVEKLKLPNGDWDKFTIAAIFRDYTFLASSYLLEPCWENWCKNPDQGYGLGREVLPKSVSRPMYRCAQILDLPPFMSYAASYALFNYTLADHSKGLEDYSNLRLVRAFERGLDPKSSEAGFILTHVDMVKETGSLIAGALKVIDTLEQNGDRSDINDGYREILRTMEKIEASMEDMWANSKPAEYLSFRVFIFGITNQSMFPNGVIYDGVENNQPLSFRGESGANDSIIPLLDHLCQIPMPSTPLTKILHEFRAYRPLPHREFLTYVREKSEEIGVQNYSVQDSETAVLFLRVLNHVRSFRWRHWLFAREYIIRRTPHPTATGGSPIVTWLPNQLSAVMELMISIYETYLAPKEGVTSVNGEGDRIASHRKQVEPIMELVRDQKEKLAKEVEKWCKERGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2P0</accession>
    <name>A0A9W9X2P0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UmuC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788716.1">
        <property type="nucleotide sequence ID" value="XM_056935792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2P0"/>
    <dbReference type="GeneID" id="81626041"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000006">
        <property type="entry name" value="DNA polymerase iota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404:SF1">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="2">
        <location>
            <begin position="13"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5482744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="621" mass="69632" checksum="17E1D89EE18A8593" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2Q8</accession>
    <name>A0A9W9X2Q8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_006223</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788749.1">
        <property type="nucleotide sequence ID" value="XM_056935825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2Q8"/>
    <dbReference type="SMR" id="A0A9W9X2Q8"/>
    <dbReference type="GeneID" id="81626074"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000007">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="14">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5482777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="103" mass="11372" checksum="504DA6BE1E631BEB" modified="2023-11-08" version="1">MSGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISAMIYEETRGVLKSFLESVIRDAVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2Q9</accession>
    <name>A0A9W9X2Q9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_006600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788136.1">
        <property type="nucleotide sequence ID" value="XM_056936201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2Q9"/>
    <dbReference type="GeneID" id="81626450"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="223"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="474"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="486"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5480706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="557" mass="61959" checksum="1DC993CABF53CCEC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2S7</accession>
    <name>A0A9W9X2S7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_007006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788542.1">
        <property type="nucleotide sequence ID" value="XM_056936607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2S7"/>
    <dbReference type="GeneID" id="81626856"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1300.10:FF:000003">
        <property type="entry name" value="Amidase signature enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF10">
        <property type="entry name" value="ACETAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="65"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="202"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5481112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="573" mass="63037" checksum="BE90D90E61FE8E8A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2U3</accession>
    <name>A0A9W9X2U3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788809.1">
        <property type="nucleotide sequence ID" value="XM_056935885.1"/>
    </dbReference>
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    <sequence length="1599" mass="175508" checksum="83B37F125B880FE3" modified="2023-11-08" version="1"> </sequence>
</entry>
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        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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            </authorList>
            <dbReference type="PubMed" id="36726175"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
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        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
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    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
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    </dbReference>
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    <dbReference type="GeneID" id="81624643"/>
    <dbReference type="Proteomes" id="UP001148312">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
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        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
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        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
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        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037350">
        <property type="entry name" value="LMO_FMN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF86">
        <property type="entry name" value="DEPENDENT DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 7" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="101"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>FMN</name>
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        </ligand>
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            <position position="152"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
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        </location>
        <ligand>
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        </ligand>
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            <position position="180"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        <location>
            <position position="189"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
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        <location>
            <position position="267"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
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    <feature type="binding site" evidence="7">
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            <position position="289"/>
        </location>
        <ligand>
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        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
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            <position position="294"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
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            <end position="326"/>
        </location>
        <ligand>
            <name>FMN</name>
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        </ligand>
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        <location>
            <begin position="345"/>
            <end position="346"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5484804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="404" mass="43858" checksum="06432830B238D87F" modified="2023-11-08" version="1">MPDETYGSYQNEIYGKGSLMGILPSVTTDPRLLEGQARKALGERSFNYVAGGAGEKATMDSNRLAFRQWKLLPRMLRSMDHQDVSVKLFGQTYNNPLVMAPVGVQGIFHEDKETGLAEVCEEIGVPYIMSTAATSTIEEVAAASNNGHRWYQLYWPHDDEITLSLLQRAKAAGFTVLVVTLDTWSLGWRPADLDKGYVPFIKGVGCQVGFSDPVFRKKFEDNQGCKIEEDIVGASQAWLNQIAAGGAHTWEELALLRKNWDGPIVLKGIQHVEDAKKALEYGCNGIVVSNHGGRQVDGAIGSLDVLPEIVDAVGEQMTVLFDSGVRTGVDIIKALALGAKAVLVGRPVIYGFGIGGRDGAKQVLKGLLADLWQSMGLAGIRTVADCDRTVIRRVQHGGDVKAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X685</accession>
    <name>A0A9W9X685_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <authorList>
                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5484909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="77" mass="8490" checksum="3B1AADECF330D991" modified="2023-11-08" version="1">MKFTRKTWGYPTESPDDSKAGRRHFGEILSFDLHWASQNLAGPEPQTDVDLADNWIQGTQVPAGIALGLDESTDTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6E9</accession>
    <name>A0A9W9X6E9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">N7539_005331</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056934933.1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
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            <end position="263"/>
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            <begin position="285"/>
            <end position="479"/>
        </location>
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            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
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            <end position="25"/>
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            <end position="100"/>
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            <end position="163"/>
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            <end position="195"/>
        </location>
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            <begin position="213"/>
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        </location>
    </feature>
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            <begin position="245"/>
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        </location>
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    </feature>
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            <end position="316"/>
        </location>
    </feature>
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            <end position="341"/>
        </location>
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            <end position="360"/>
        </location>
    </feature>
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        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5485343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="510" mass="55384" checksum="92795D0F7BDAA939" modified="2023-11-08" version="1">MPRPAAKRNRSLKASRASNSKSAPESESAEITKAPAPESPSVDNAIKHSRRTLRSQTPLAQRNEDSLASSPAGDKPGTGSRPGTGSRPPTRSRGYSSTLSLAGRKGDAGSRVPGTPGFEHSVLGTFRRRPRQQSILHMMQDEDDTLELDDEDLLGGLSPEDESTTPLHLTRGKSLLIAQDSPLPSTSKSTPSSPGSRKRRRSDQQQQPPPQQHNIEIQVPQSPSVVINHSVVDRVEDIPNPTPVPQSQDILPSQTIPQSQTSNLYESTPQPLRFADILSQTMLPPASSPMSSIATGPGSPGATVALKGRRGRKPRNLAHLSTAILQEKALPRRRKPRRRGRTLGEFEVPSDEDDEDEERSDDGMHHATSGDEDELNHQPTRRKRRSGSSVKPKPFGNVHDKPRLNSPTKTRNRSKSAPRGKSVDVQGSSRRSRSRKSVGTDKENVMQASSPSSSPLSSPPDSEGSDFEGGDGVGKPPRRIVSAELRAAVEKFKEVDQWEMEFEDVSGSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6J7</accession>
    <name>A0A9W9X6J7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fringe-like glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_005277</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790073.1">
        <property type="nucleotide sequence ID" value="XM_056934879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6J7"/>
    <dbReference type="GeneID" id="81625128"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="9">
        <location>
            <begin position="214"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5485289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="496" mass="55513" checksum="B7414A4B2D36647D" modified="2023-11-08" version="1">MLWKGGDGLASASWAWRKIARFAIAFLAVLGVLILLWPSRAREAPAAAAAPADDAGPVQSNFTISPNVKCDVDLKMLDRFGVEKLAQYTRRRIAVTFSDEQVPMRQQMDQPLLEGQTRGAASGGESPHEQALDGCTIPAPITIVTPRPPKMADASHIDFGVATSISRLNESLDQFAHWAGYTRTRIFAIVEPMESESDTREGIANVKAKADSIGINLIVSESKDDYLHRYFALVSLLEKNLREATQWACIIDDDTFFLSMPALVQALGEYDHTKPMYVGGLSEGIPQISEFGIMAFGGAGVFLSRPLLSILGTVYEVCEQMTWTGDRRIAHCIYDHTTTKLTVDHRLRQLDLLDDASGFFESGREQPLSVHHWKSWFHMDMPKLSTISEVCGPSCLLRQWQFSDGWFLTNGYSIVKYGFPPAPDDVSVEMTWNPLNGATIESYLHELGPIRRKDEHKMSYLLQDSQMESDGSVTQWYILRDKIQGDQIFELTWQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6L7</accession>
    <name>A0A9W9X6L7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-galactose transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_005436</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790232.1">
        <property type="nucleotide sequence ID" value="XM_056935038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6L7"/>
    <dbReference type="GeneID" id="81625287"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5485448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="37069" checksum="FF0F4C1C39F4DB85" modified="2023-11-08" version="1">MHTVAEKQTSPARQAVTLGVGSNHDVKSWTYVILLMLQHSLQSQPSSNPDRYEPLSGIVVIEVAKFIISLLVIVQSETTASIRSVAQGTVLNFSNDATAAALLFTAATILQSVGAHYLDLIPYLVLSQLKTIVTPLFARIILHQRYPLRNWLFIAMMVLGIVLAQLGAGSAKTSTQGFRTQAMARGAIAMILAGICVALGSLSIERTLKKSGLLFHCNAQLAAYSSSFAMLYFCWQTKFDFDHFFRGFDALAWIYIGLQVSGGFIVAKCVQMTSTVTKNYAQGLGFALAVFTPPLVAGQHISFQLLIGVGLILASVLGSSASNQRKPATEEVPSEKSSLQEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6T6</accession>
    <name>A0A9W9X6T6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Kynureninase</fullName>
            <ecNumber evidence="5 6">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Biosynthesis of nicotinic acid protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BNA5</name>
        <name evidence="9" type="ORF">N7539_005159</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="5 6"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6T6"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000031">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF0">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="8">
        <location>
            <begin position="139"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="175"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5485171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="503" mass="56551" checksum="F8BD2BF391A9F974" modified="2023-11-08" version="1">MGSRQHLRDIQTGPPLDYHDDIRANSREYAEALDKEDSLRGFRSEFIIPSKTDLKRKVLSDAQSLEDNADERCIYLCGNSLGVQPRNTRQYIERYLQTWARKGVFGHFVPHSDQLLPPFVEVDSAAAKLMAPIVGASESEVAVMGTLTANLHLLMASFYQPTTEKYKIILEGKAFPSDHYAIESQILHHKLDPKQAMVLIEPENPDRPVLTTDQIIKVIDENASSTALILLSAVQFYTGQYFDIQRITTHAHSRGILIGWDCAHAAGNVDLRLHEWDVDFAAWCTYKYLNSGPGGMAAIFVHERHGQVDEQQNFRPRLAGWWGNDLKTRFQMKNGKLETILDPSTLIMTVILRLSSDFVPQPGAAGFQLSNPSVLDINAVVASLEIFKRAGMKSIREKSLHLTGYLEHLLLTYPLDSSPESKPFIMITPANPAERGAQLSLRLRPGLLEKVLPYLEEHGVVIDERKPDVIRVAPAPLYNTYTDVWEFCQVFFAACREAVQPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X721</accession>
    <name>A0A9W9X721_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_005475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790271.1">
        <property type="nucleotide sequence ID" value="XM_056935077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X721"/>
    <dbReference type="GeneID" id="81625326"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000005">
        <property type="entry name" value="50S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_uL14_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5485487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="131" mass="14088" checksum="A1441F3E51C449B1" modified="2023-11-08" version="1">MIQLKTLLTCIDNSGASIVECVNVLKKKRPATIGDRIVVVVQKQRAATSEGSSGTALANKVRRGDIRHAVVVRVKKELQRADGTVVRFGDNACVLVNKSGDPIGTRMNGVVGQELRGKQWSKILSLAPINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7C4</accession>
    <name>A0A9W9X7C4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789804.1">
        <property type="nucleotide sequence ID" value="XM_056934610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X7C4"/>
    <dbReference type="GeneID" id="81624859"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="100" mass="11438" checksum="8860DB963BC1FDA3" modified="2023-11-08" version="1">MDETLKRPSHSQDGSGIDNGNIEFLECDARLEGGPNQVEWRMLSPSMDSGVPQKVELGKSSELHLWECDLRREPQVSKWERWGDQVECGRWSSGLNRRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X8E4</accession>
    <name>A0A9W9X8E4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790359.1">
        <property type="nucleotide sequence ID" value="XM_056935165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X8E4"/>
    <dbReference type="GeneID" id="81625414"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="354"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5485575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="632" mass="69852" checksum="C90BBC0859FDF175" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCN6</accession>
    <name>A0A9W9XCN6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein kinase RIO2</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Serine/threonine-protein kinase rio2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_003820</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790963.1">
        <property type="nucleotide sequence ID" value="XM_056933422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCN6"/>
    <dbReference type="GeneID" id="81623671"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000053">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000566">
        <property type="entry name" value="Serine/threonine-protein kinase rio2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="16">
        <location>
            <begin position="66"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="349"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5488930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="416" mass="46806" checksum="30D8514F61774178" modified="2023-11-08" version="1">MKLDAKALRYLTSEDFRVLQGVEAGSRNHEVVPTPLISQLSGLRGGSGVHRSISNLAKTNLIAKVKNAKYDGYRLTYGGLDYLALNAHQKQKVVYSVGNQIGVGKESDIVVVAHSSGSQRILKIHRLGRISFRTVKTNRDYLRHRNTGSWMYMSRLAAMKEFAFMKALRENGFAVPEPIAQNRHTIVMELIDAFPLRQISRVPHPEALYSELMDIILELARFGLIHGDFNEFNILIKEIADPSEKGKAAADADTEESEENIRLEPVIIDFPQMVSIDHVNAEMYFDRDVNCIKRYFQRKFHFVSDVPGPFFSDAKKNFLRNPGKRLDVEVEASGFSRKMARELETYMKEVGADGDAGAARDDLDDDDEDDDDDEEDEGDSEEEDTHQEPEVGSSSTEVEESAKRLEALDVSGSSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XD88</accession>
    <name>A0A9W9XD88_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translocon-associated protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_003613</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Is probably involved in a pathway contributing to genomic integrity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IRC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790756.1">
        <property type="nucleotide sequence ID" value="XM_056933215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XD88"/>
    <dbReference type="GeneID" id="81623464"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040925060" description="Translocon-associated protein subunit alpha" evidence="10">
        <location>
            <begin position="24"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5488723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28006" checksum="96153B9D05293762" modified="2023-11-08" version="1">MTRFGLLSLALLSLQAFVGTGFAAETEKVAETDAPTLAVSAQASFPASEIFGVKLVNGHPTQALIAFTNDEPNPVTVNFVGGSLWTLDEQSKNVRNLTATRYAVEIPANSKESLSYSFATEMHPVDLRLNIAAIMSDSEGHFFTLQAFNGTVSVVEPETSIFDPQIIFLYFFLLACFVGVVYFFYTVWVAPYFPQKRKAVRSSEKKTPAKREIVEETPSPAVTSATTYNADWIPAHHITRPEARKVKSGKSKARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDB8</accession>
    <name>A0A9W9XDB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec1 family superfamily</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791169.1">
        <property type="nucleotide sequence ID" value="XM_056933628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDB8"/>
    <dbReference type="GeneID" id="81623877"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.830.10:FF:000005">
        <property type="entry name" value="Sec1 family superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="648"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="77034" checksum="A91F515DB87DB975" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDR6</accession>
    <name>A0A9W9XDR6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_004251</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791394.1">
        <property type="nucleotide sequence ID" value="XM_056933853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDR6"/>
    <dbReference type="GeneID" id="81624102"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5489361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25785" checksum="75C2E4318CD2728E" modified="2023-11-08" version="1">MNTFSMKALAKTLPSVCQQYQSSLVRLGALRHFSSTPKDSSSLKDKTRNIENQILDRQPESADTSSPLSAISKMMTGGRPSAPSRVNADYARLAESLEADMIRNPYADRAPPHHLHVFAHKHNTILTLTRPNGNPILSMGTGQIGFRKGGRAGFDPAYQLSSHVLSQIQERGLLMEIKRLEIVFRGFGKGREGFTKVLLGNEGRKIRGLVSRVTDSTRIKFGGTRSRKVRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDS5</accession>
    <name>A0A9W9XDS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791558.1">
        <property type="nucleotide sequence ID" value="XM_056934017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDS5"/>
    <dbReference type="GeneID" id="81624266"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="95" mass="11135" checksum="57401DD72379EB2D" modified="2023-11-08" version="1">MRLGEDFPFSAGSEEEEEEEEEEEEEEDLTLSDGSRPLPGRTDTTSALEESPPVWGTRLRSTDHQEDLPRLGRCRWFFLEPDFYDFLDYLHAHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE75</accession>
    <name>A0A9W9XE75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sorting nexin-41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_004630</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791773.1">
        <property type="nucleotide sequence ID" value="XM_056934232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XE75"/>
    <dbReference type="GeneID" id="81624481"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06867">
        <property type="entry name" value="PX_SNX41_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
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            <dbReference type="PROSITE" id="PS50195"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="KAJ5489740.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="629" mass="70177" checksum="8482295F16D6D896" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEI9</accession>
    <name>A0A9W9XEI9_9EURO</name>
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        <recommendedName>
            <fullName evidence="5">Regulator of phospholipase D SRF1</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">N7539_002376</name>
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        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
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            <dbReference type="Google" id="ProtNLM"/>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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                <person name="Frisvad J.C."/>
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            </authorList>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="35119" checksum="F7866C1E5E9F81DF" modified="2023-11-08" version="1">MTQSKTNVLIVGATGYIGGSVLAEILGSQDAQNLCVSALIRRPEQGARLEKLGVKPIEFQGLDDLETCREAASLIPTMTSGTSILGDHPYTGNPNPQKIWSDINDDIFHMEMYHPERYGQRVTDIAVVETGQALGVKTYIVVPPTIYGKGSGPFATLSQQVPNLARFARKLGVSPVIEGGQGTWNHVHISDLSRLYLQLFRAIQEQPTWLPSGPRAIFFAESGEHTWLQVSQGIAGALKRHNLLATAEVKQVSLQEAADYITGGDVNFVEITLASKKIHSARARADFARERLGWSPSHGDEEFLNHFEAELDSMLEELATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEW5</accession>
    <name>A0A9W9XEW5_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
        </source>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAJ5489768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="81624509"/>
    <dbReference type="Proteomes" id="UP001148312">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="117" mass="13329" checksum="4084EDE7FDCBC2CB" modified="2023-11-08" version="1">MRTPPVTEVEILYDRESDSPLPRSAIDLTFTQSRRRGRFRRGEKQQPPLLGDGLDLEDPMVSSHAGVNSELGHDEKAAMDPSHILNGRDRLRYIKPATMSKTDKAEENEKLKYDFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEW6</accession>
    <name>A0A9W9XEW6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_002413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791975.1">
        <property type="nucleotide sequence ID" value="XM_056932016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEW6"/>
    <dbReference type="GeneID" id="81622265"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5490846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="149" mass="16549" checksum="AB46BAEF2A3B5919" modified="2023-11-08" version="1">MGESIDEDIIRSNVLISISQHQIVLRLCSFPVEVMGSFMSHEESCHGENLQDQTQCHRVDPKWTTFLTVMFASGKIGRLLLWDPASGALTGLPTNDCHRVLFLYSLNDVSRSPESTPTLVFPDSHFACGRRTALARDMSNAAKFNPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF00</accession>
    <name>A0A9W9XF00_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">U6 snRNA-associated Sm-like protein LSm7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_002519</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792081.1">
        <property type="nucleotide sequence ID" value="XM_056932122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF00"/>
    <dbReference type="GeneID" id="81622371"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000043">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="39"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5490952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="127" mass="13768" checksum="5669ED727C50C56E" modified="2023-11-08" version="1">MSERGSFRGGRGGGGGRGGRQQQKTGTSAQQQQEKPKKENILDLGKYMDKEVQVKFNGGREVTGTLKGYDQLMNLVLDDVKETMRDDAGNQTTRSLGLIVARGTLIVLISPADGSEEIANPFVQPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF59</accession>
    <name>A0A9W9XF59_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791761.1">
        <property type="nucleotide sequence ID" value="XM_056934220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF59"/>
    <dbReference type="GeneID" id="81624469"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040992967" evidence="1">
        <location>
            <begin position="21"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="216" mass="23394" checksum="C69B34B4EFDF1178" modified="2023-11-08" version="1">MIASFQLLTGLLALTTSAVSSVVQPRSITPPEGCPIPTWVVNNFQWHNASHSLDCVHHPYDYPEACLCGSGWCKPDPATCNGTMVNPCYTGMPNYEPWGYGPLETLDIDFADGLQCHDQYIGYRIHDIGNGASNCGYADRGQGRIVSFYGTSNLDSSIGHMDYVLGSGHALTCANGSSITYSGSVDFPLTCTHDAYFNATCTAPVFEIPVLSYQWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFQ0</accession>
    <name>A0A9W9XFQ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_002961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792523.1">
        <property type="nucleotide sequence ID" value="XM_056932564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFQ0"/>
    <dbReference type="GeneID" id="81622813"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5491394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="213" mass="23586" checksum="C0B6684525AC4F52" modified="2023-11-08" version="1">MEDVLSAPISNGNVPSRRQSHQVPRLPLLRFCKHLAREEGPIPVRRCNGPWAWQPLCGEMKKSVSESVGAWHTYQWPVWALFAPFASTCSPPPPVSARGVEGDVTAKISTFKPVLELLGFHARATPEARQTGQGRGCAKRLVPVDEMNITKKLGRPKRGPDSPIRVIHDPLTLASLVDMVPPGSVERAEATKMEETRREASVNQRMMMMILPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFR0</accession>
    <name>A0A9W9XFR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="81622840"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="283" mass="31738" checksum="3156DFEA95A4DF07" modified="2023-11-08" version="1">MSLTKLIKCPDPSRSNRSQSRANLRYGDVEKEGLALQKCFSPRPGDSDRVQARVIEFSGHSPWSPQDFVRTGWAIERLGWAEAGRAPSFPGGRPPQGWNPASAPLTSLPWSIRPVARQLGLSLGPLYRTVSLFKMVQDDAESDYSDYIIQVGPGVIVSQLSSRFRGPHWSDVALAVYKRYERAPLRYVFRVDITNEVVERLISDKIYSATTTGLRWPDSVRREWTYGSREYRALLGTPLGRGVVALVLRGYDRGTKLISSISTFSDAHHVSMHMLFVISDRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFV0</accession>
    <name>A0A9W9XFV0_9EURO</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_003062</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056932665.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81622914"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:transport along microtubule"/>
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    </dbReference>
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        <property type="entry name" value="Cytoplasmic dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
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    </dbReference>
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        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
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        <location>
            <begin position="512"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5491495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="694" mass="76166" checksum="DBD3C4860A42587D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGF8</accession>
    <name>A0A9W9XGF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">mRNA-capping enzyme subunit alpha</fullName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="12 17">GTP--RNA guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 17">mRNA guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">N7539_003301</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 17">Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the eukaryotic GTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="3 17"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792862.1">
        <property type="nucleotide sequence ID" value="XM_056932903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGF8"/>
    <dbReference type="GeneID" id="81623152"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000275">
        <property type="entry name" value="mRNA-capping enzyme subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000011">
        <property type="entry name" value="mRNA-capping enzyme subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017075">
        <property type="entry name" value="mRNA_cap_enzyme_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036959">
        <property type="entry name" value="mRNA_cap_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 17" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="5 17" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="mRNA capping enzyme adenylation" evidence="20">
        <location>
            <begin position="42"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA capping enzyme C-terminal" evidence="21">
        <location>
            <begin position="245"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" description="N6-GMP-lysine intermediate" evidence="18">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
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        <source>
            <dbReference type="PIRSR" id="PIRSR036959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ5491734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="404" mass="46935" checksum="4BDDBFE1E90279A6" modified="2023-11-08" version="1">MSHAVPDLDAIGVKAEADLAESFRREVANLLGRNNLNFPGAQPVSFSAKHLVELQKEDYFVCEKTDGIRCLMYFARGESPEVPEIHYLIDRKNDYRYVPGLHFPLPDDETFQSFHVDTLIDGELVNDTYEDGTTQLKYLVFDCLVLDGQSLMHRTLDKRLAYFKEKVLKPYNAMYRKFPQEKEHRAFAVEDKSTQFSYGIEMMFRDIIPKVKRIHGNDGLIFTCRSTPYRIGTDEHILKWKPPAENTIDFRMRLEFPVLEPDTDDEADGITAPYPDYDAIPICHLFTMLNSNEYRHFGEMYVTPEEWENLKAMQVPLDDSIVECYKDPEQRWRFYRLRDDKADANHISTVEKVLESIEDRVTEEDLIRIAPAIKSAWKKRQAEGKPRSAGPPVGTNGVKRKYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGG7</accession>
    <name>A0A9W9XGG7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">EF hand domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_001298</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792932.1">
        <property type="nucleotide sequence ID" value="XM_056930901.1"/>
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    <dbReference type="GeneID" id="81621150"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
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        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF187">
        <property type="entry name" value="EF HAND DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G07310)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand_7"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
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            <end position="447"/>
        </location>
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        </location>
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        </location>
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            <end position="58"/>
        </location>
    </feature>
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            <end position="611"/>
        </location>
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            <end position="1043"/>
        </location>
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        <location>
            <begin position="1068"/>
            <end position="1077"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5492552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1137" mass="128187" checksum="D411709752DEB6B9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGI8</accession>
    <name>A0A9W9XGI8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792859.1">
        <property type="nucleotide sequence ID" value="XM_056932900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGI8"/>
    <dbReference type="GeneID" id="81623149"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052585">
        <property type="entry name" value="Lipid_raft_assoc_Zn_ADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482:SF4">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="22"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="339" mass="36820" checksum="1123431093CF8B0E" modified="2023-11-08" version="1">MQAIRLHPAPSGAISYSPSNPAPSSALRLDYDIPVPSLSAPGELLVRVKASTVIRDMLSWPEVYSHQYAIPGWDVAGIVTEVYSEKSEFKPGDEVFGMANTDRAATWAEYTIMKEDEVTRKPATLTFAQAAALPLSAQTAYEALFEHARIPISNRKGLVAESDAKVKEQRVLITGAAGAVGVYLVPFASAANVHVVAASSSNVRNEEFLRGLGADEVVEYKMLDDYAGRFDVIIDVVGGEVLAKCWDYVAETGRLITVDSASFNFVKEHEKRGLRKMGVDARFFIVKGSPEALRCIAEMVDAGAVGSFVAEILPMARVREAYDHANSKMSARGRVILTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGQ8</accession>
    <name>A0A9W9XGQ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_001423</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793057.1">
        <property type="nucleotide sequence ID" value="XM_056931026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGQ8"/>
    <dbReference type="GeneID" id="81621275"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="275"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="587"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="606"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5492677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="693" mass="77014" checksum="10D57C52B4463A12" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGW0</accession>
    <name>A0A9W9XGW0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="5">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_003110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792672.1">
        <property type="nucleotide sequence ID" value="XM_056932713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGW0"/>
    <dbReference type="GeneID" id="81622962"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000014">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009725">
        <property type="entry name" value="PRK13252.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5491543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="499" mass="53760" checksum="589CF845E7B59C0B" modified="2023-11-08" version="1">MALSFSTRQLYYDGQIRPATSGKTFQTINPATAKPLADIQIASHADIDAAIQAADRAFPTWSKTPYIARARILQKAATLLRERNDEIARVETLDSGKAFTETSTVDVVTGADVLEYYANYIGSGGLNGETTQLREDAWVYTKKAPLGVCVGIGAWNYPIQIALWKSAVCLAAGNTMVYKPSEFTPLHGETLAQIYTEAGLPAGAFNVVNGAGDVGAYLTSHPSVAKVSFTGQVSTGMKVAGSAAGNMKYVTMELGGKSPLIICPDAELDNAVDGAMMANFYSTGQVCTNGTRVFVPRAMKLAFEKRLLEKLAFVRAGPLFDDQTNFGPLSSEAHYKKVLEYIHHGIQTDRATLLAGGPGKPSNLPQDLQAGYWVRPTIFTDCTDEMRIVKEEIFGPVMSILYYDSVDEAVRRANATEMGLAAGVFTKDLNQAHRLIDQLQAGITWVNTWGESPAEMAVGGWKKSGLGVENGHKGIESWVQNKSTLVDMSGAVATVFAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH37</accession>
    <name>A0A9W9XH37_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2 11">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_003230</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2 11"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792791.1">
        <property type="nucleotide sequence ID" value="XM_056932832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH37"/>
    <dbReference type="GeneID" id="81623081"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="34"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5491663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="374" mass="42355" checksum="ED8CF8E5C2A7C176" modified="2023-11-08" version="1">MSKSVGHTPIAVKEMAQFTERNVMGVLFETTTRYQQLELVGVGISGLVCSARDRLTHKTVAIKKLAEPFKTASIAKYVFREVKLMKQLDHENIVRLTDVFISPSEDIYLVTDLMATDLDTLLKSKKIDEKFSQYFMYQIMRGLKYVHSAGVLHRDLKPSNILVNENCDLKICDFGLARVQEIQMTGYVSTRYYRAPEVMLNWGRYNEKVDIWSAGCIFAEMILGRPIFPGKNHIDQFCVIVQLLGTPPDNVTANVTNQSTLSFIRSIPTRPRKPLAELLPITDRDSIGLLEELLQFDPEKRCSAAKALEARYLALYHDPGDEPVAAERFDISFLEANLTADVWKNITYGEILGYHEQAVGSTEVTPYLSRMDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH87</accession>
    <name>A0A9W9XH87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792701.1">
        <property type="nucleotide sequence ID" value="XM_056932742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH87"/>
    <dbReference type="GeneID" id="81622991"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="83" mass="9756" checksum="E467D3083572C000" modified="2023-11-08" version="1">MTTIFSDDFTTYGHIYGFKTYKHNDDSEIQSTILKTLLVSSVRVNISNIDNNEEKEEQKDRKSIPSRKLNSYDDIHDILHDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHC4</accession>
    <name>A0A9W9XHC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">37S ribosomal protein MRP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_001793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793427.1">
        <property type="nucleotide sequence ID" value="XM_056931396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHC4"/>
    <dbReference type="GeneID" id="81621645"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1480:FF:000001">
        <property type="entry name" value="30S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006477">
        <property type="entry name" value="PRK08881.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836:SF19">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5493047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="117" mass="13638" checksum="38568821855B0A78" modified="2023-11-08" version="1">MSKAASMFHPKRLDLSGFVNTRVIRDHNKRNAFAQMEPERQALRYIIRNTSLPQRTRAQAQLQLSQMHCYTRPTQIKNRCVASGTARSVFRDFRLNRFQFRMQALAGELPGVKKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIG0</accession>
    <name>A0A9W9XIG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aminotransferase lcsP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_002245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793879.1">
        <property type="nucleotide sequence ID" value="XM_056931848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIG0"/>
    <dbReference type="GeneID" id="81622097"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000010">
        <property type="entry name" value="Branched-chain amino acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="AMINO ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825:SF2">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5493499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="375" mass="40808" checksum="156B41C52346E75D" modified="2023-11-08" version="1">MFPPPPAALDWQDIGFKVRDVNGHVECHYSQSGNGQWSAPRFVRSPYLSIHGMAPGLNYGQQVYEGLKAFRHAENSKITIFRPDRNAKRMQHSAEVVSIPPVPESLFLDCVRLAVGANAEFVPPFESGAAMYVRPLLFGSSAQLGLTPPDGYTLAVFVMPTGVYHGASAVDALILEDFDRSAPHGTGNAKVGGNYAPVLRHSDRARRDGFGITLHLDSATRSEIDEFSTSAFIGVKRTGDRVTVVLPDSRNAIDSVTAGSVGDIARHLGYEVEKRQVRYEELSQFDEVIAAGTAAALVPIRSITMRSEGDKFGYNCGEQAQGGEVCVKLLQTLRGIQSGSIADPQGWNYEVTAPPKEWMEEGNEEKIDQRGTTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIY3</accession>
    <name>A0A9W9XIY3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_001965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793599.1">
        <property type="nucleotide sequence ID" value="XM_056931568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIY3"/>
    <dbReference type="GeneID" id="81621817"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF3">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="5">
        <location>
            <begin position="17"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="4">
        <location>
            <begin position="191"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="3">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5493219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31794" checksum="01EBFF637EA1EC6E" modified="2023-11-08" version="1">MPSATPWSRPDTRNRPIAIIGAGIMGRRIAMMWLAAGYNVILCEKQASNHEPALQYIKNNVEKQAAKLGTKPGTGRFTTSMEEAIESAWMVIEAVPEILELKIDLIGQLDHLAPPDCIIASNSSSLRSSQMLVNTKRNYRICNGHYYMPPEQLYFEVMSCGETDPDIFPFLMEKAAAAGFKPVHARKESTGLVFNRIWAGIKRECLLVLSEGITDGGTIDEMFKSWFQANKGPCQMMDMVGLDTVYNIETVYSQELHTDPRPKDWLKTAYVDKGNLGAKTGKGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLH2</accession>
    <name>A0A9W9XLH2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794196.1">
        <property type="nucleotide sequence ID" value="XM_056929903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLH2"/>
    <dbReference type="GeneID" id="81620152"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039703">
        <property type="entry name" value="Nta1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750:SF26">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="406" mass="44700" checksum="AA090E94EF52285E" modified="2023-11-08" version="1">MRIATLQFAPKLGDVEGNIKRANDLLGKQNFTGLQESSSQELSGRGDIDFLRPDLLVLPELAFTGYNFTSREAIEPFLEQVGDGPSAQWAREIARRLHCKVCVGYPEIEHSSDGSGSPKYYNSLLVVDESGSVIHNYRKSFLYMTDETWATEGDVALGLCQLPFPSVGSSEIPENRSQLHREDSGPRRQVATSFGICMDINPYKFEAPYSAYEFANRARDSGSQLVVLSMAWLTHMSQQEMTDLRGRPDMDTFTYWLNRFMPLISKKMRHVGDIDGSSASTENGVKRAVLVFANRAGEEAGADDTKPVARYAGTSTIMALTQNPRKAAAGARSASGSPEKRPAAMIDPEEASEDEDEEVDTQVVCWDLLGAAEEGICFADTTAVPKMAFRLRSRGGQSDSDEMSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMB9</accession>
    <name>A0A9W9XMB9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PHD finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_000654</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794551.1">
        <property type="nucleotide sequence ID" value="XM_056930258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMB9"/>
    <dbReference type="GeneID" id="81620507"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000008">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000007">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="414"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="468"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="378"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1065"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5495538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1098" mass="123244" checksum="0AA54A0A62C892DC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMI8</accession>
    <name>A0A9W9XMI8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal specific transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794686.1">
        <property type="nucleotide sequence ID" value="XM_056930393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMI8"/>
    <dbReference type="GeneID" id="81620642"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474:SF1">
        <property type="entry name" value="FUNGAL SPECIFIC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="25050" checksum="8DA018ECBF127441" modified="2023-11-08" version="1">MQLSRTAYRAALFPLSVNPLLARASLQHAACWSLSSNHGTYPAHPFASTLSSSSCSSRLYGVLFPQCIARPNANQPVFKPSSTPSNSNSTAKAMSTSTSPGSPSAASTQHSTQSTSAAQTDTNGNTSNQEKDGHEPEHAHDHKEQLYLPSTEDASSHSGNIRLDVSSESGVTLDHLGPMVVNVDGSLSRIGNWAQMAEIERRNTLRIIGKRNRERLARLKAEGVQVGGVEEREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMX9</accession>
    <name>A0A9W9XMX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H/ACA ribonucleoprotein complex subunit NOP10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nucleolar protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nucleolar protein family A member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">snoRNP protein NOP10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_000330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794227.1">
        <property type="nucleotide sequence ID" value="XM_056929934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMX9"/>
    <dbReference type="GeneID" id="81620183"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.40">
        <property type="entry name" value="H/ACA ribonucleoprotein complex, subunit Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5495214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="79" mass="8920" checksum="372FE0F0788A924C" modified="2023-11-08" version="1">MHLMNASLPPTTSLTFLEKYTLGADGKRVYTLKKVVDGKVSKSAHPARFSPDDKYSRHRVTLKRRYGLLLTQQPEEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMY8</accession>
    <name>A0A9W9XMY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0145 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794483.1">
        <property type="nucleotide sequence ID" value="XM_056930190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMY8"/>
    <dbReference type="GeneID" id="81620439"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.70">
        <property type="entry name" value="Hypothetical protein apc22750. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00338">
        <property type="entry name" value="UPF0145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145_YbjQ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068:SF2">
        <property type="entry name" value="UPF0145 PROTEIN SCO3412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="UPF0145 PROTEIN YBJQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="YbjQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="127" mass="13840" checksum="739455CE8A40AB2D" modified="2023-11-08" version="1">MSSSKKTKELPSCFTDTHGVITSTMNDLPGYKIKQVLGTIYGITVRARNWSADIGGGLRTAVGGEIRIFTNLMYTSREEAMERLVGECMSRGGNAIIAVRFDVDNFGSCSQICAYGTACVVERVEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMZ6</accession>
    <name>A0A9W9XMZ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3 6">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_001058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3 6"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794955.1">
        <property type="nucleotide sequence ID" value="XM_056930662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMZ6"/>
    <dbReference type="GeneID" id="81620911"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5495942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="356" mass="38956" checksum="F1E70D3B83DBAB05" modified="2023-11-08" version="1">MAAQTANLRPLARTMSTALTTLRTTTYRAPVNRSAITLPCYMRSTLVPRIQSRHSSYHSPEPVTNAPNARKKVTMVTLRNLYRKGEPIAMITAHDFPSARAADESGMDMVLVGDSLGMVAMGLENTTEVIMEEMLLHCRSVARGAKAAFLIGDLPMGSYEVSPEQAVQSSLRFIKEGRVHGVKIEGGEELAPTVKRITQAGIPVVGHIGLTPQRQNALGGFRVQGKTSAGAVQLLKDALALQEAGAFMLVLEAMPPEVATLITSKLQIPTIGIGAGNGCSGQVLVQVDMTGNFPQFVKRYADVWSEATRGMQQYREEVKSRQFPSPEYTYPITKEELSKFQETVDQTYERLRTGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XP33</accession>
    <name>A0A9W9XP33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell cycle control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_001241</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795138.1">
        <property type="nucleotide sequence ID" value="XM_056930845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XP33"/>
    <dbReference type="GeneID" id="81621094"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="487"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="621"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5496125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="730" mass="84696" checksum="E0AE5F449212B740" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XPN8</accession>
    <name>A0A9W9XPN8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_001200</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795097.1">
        <property type="nucleotide sequence ID" value="XM_056930804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XPN8"/>
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    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
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        <property type="entry name" value="Bromodomain"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain-like_sf"/>
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        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
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        <property type="entry name" value="GCN5"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
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        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
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    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="67"/>
            <end position="222"/>
        </location>
    </feature>
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        <location>
            <begin position="309"/>
            <end position="379"/>
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    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
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            <dbReference type="EMBL" id="KAJ5496084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="406" mass="46837" checksum="700D9053C8227B14" modified="2023-11-08" version="1">MAVETPQSTKRKASEEPASPDSQLQPSKKARTDSPVKEEDGVLRKPPLRIVPFPEKPAVIEERHGDIEFRVVNNDGSHDSFIVLTGLKCIFQKQLPKMPKDYIARLVYDRSHLSIAIVKHPLEVVGGITYRPFNSRKFAEIVFCAISSDQQVKGYGAHLMSHLKDYVKATSPIMHFLTYADNYAIGYFKKQGFTKEITLDKSIWMGYIKDYEGGTIMQCTMLPKIRYLEMGRMLLKQKEAVQAKIRAFSRSHIVHPPPKEWKNGVTKIDPLTIPAVKESGWSPDMDELARQPRHGPNYNQLLHLLNDMQNHSAAWPFTQPVNRDEVPDYYEVIKEPMDLSTMEEKHEKDMYPTPQDFIKDAMLIFDNCRRYNNENTPYAKSANKLEKFMYQQIRNIPEWSHLADGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJA0</accession>
    <name>A0A9X0BJA0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dienelactone hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785945.1">
        <property type="nucleotide sequence ID" value="XM_056938568.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5469355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="59614" checksum="48831E0B31F4433B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJQ2</accession>
    <name>A0A9X0BJQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_009186</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786158.1">
        <property type="nucleotide sequence ID" value="XM_056938781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJQ2"/>
    <dbReference type="GeneID" id="81629031"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21675">
        <property type="entry name" value="SMP_TEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF19">
        <property type="entry name" value="NUCLEUS-VACUOLE JUNCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15413">
        <property type="entry name" value="PH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="277"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="485"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="600"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="668"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="740"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="619"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="668"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="681"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="895"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="918"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5469568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="948" mass="103991" checksum="85067D2919EF9D9C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BM88</accession>
    <name>A0A9X0BM88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786618.1">
        <property type="nucleotide sequence ID" value="XM_056938236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BM88"/>
    <dbReference type="GeneID" id="81628486"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5472072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="113" mass="12721" checksum="80C2ADCB78DF3983" modified="2023-11-08" version="1">MLYMCATKFELISVGESALLEQERGSLPPLPSLDPISDSKQAEDEDIVTEIPSQLLQPQAQSENTRPKRPRSRSTQSQENEVMPEPADLENTQRPSRVRKKTRMPEGFEIGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNA6</accession>
    <name>A0A9X0BNA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786926.1">
        <property type="nucleotide sequence ID" value="XM_056937834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNA6"/>
    <dbReference type="GeneID" id="81628084"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037830">
        <property type="entry name" value="ZZZ3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705">
        <property type="entry name" value="ZINC FINGER, ZZ DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705:SF0">
        <property type="entry name" value="ZZ-TYPE ZINC FINGER-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="354" mass="38608" checksum="168C5D020C432920" modified="2023-11-08" version="1">MSKIVSRQEPKDSQKCNLSPLDKAGPAPDLSSGPTVSTASRCRHSVQVGVGESAFNLSRSLTHRPGAGPHVHPALSRAAHQQFWSFRKPIAMDPSRDATVPSTPVDRPGTPPRPPYSPVTPVFAHLNTVAAANATIVPPPLSPSPTSHTPPNRPSNHVPSRPPGAPAVFKSEPPPVPISESENPDAIALRSAISILQMQKQQTLRDIRSLDRLKEAAAADPEAFARELAGGRLRTEDRGTVIQFSEDDAMDTDEENEQPEGFEESQEKNGSGSRFGRIPQPQNIVRMPPINWAKYQIVGEPLERMHEEQLRRPTPGEPRQQPAPEYLLASPYRPLVDQLDSPPVRPARASKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNN8</accession>
    <name>A0A9X0BNN8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">37S ribosomal protein mrp4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_007253</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787653.1">
        <property type="nucleotide sequence ID" value="XM_056936854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNN8"/>
    <dbReference type="GeneID" id="81627103"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000061">
        <property type="entry name" value="40S ribosomal protein S2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5477109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="352" mass="38778" checksum="07DCA504649AB92C" modified="2023-11-08" version="1">MIVRNLFMRQSRQLIALNRQAPVFTRSLSTEVASDTITQTPSVGSAEIAQSPVEQGIQTTSTVPEPRPLKQWDALEKRRHKFNTLGSKVQESYDPENVLRNPPKPADVTLEMLLAAGTHMGHSTSRWNPQNSRYIFGIREGIHIISLDVTAAYLRRAAKVVEEVAARGGIILFAGTRKGQKRSVVRAAELAKGYHIFERWIPGSLTNGQQILGHCKTKVVNALDQELSKFRVDLADRPSIKPDLVVVLNPLENVVLLHECGLNNVPTIGIIDTDADPTRVTYPIPANDDTLRGTNLIAGILGRAGEAGQARRLKMAQEGKTTYEPITARQLRLDPLTGTPPPGSELEKSERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNW8</accession>
    <name>A0A9X0BNW8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_007493</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787893.1">
        <property type="nucleotide sequence ID" value="XM_056937094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNW8"/>
    <dbReference type="GeneID" id="81627343"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF668">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="55"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5477349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="458" mass="49683" checksum="4D03CD8637A21EE5" modified="2023-11-08" version="1">MAAVTPQPPAYGNDKIDEGKHGSVPPSLEEEGVLKHGDVHDAFGNEEFAEIKYKTLTWWQCGLLMICESVSLGVLSLPTAIATLGMVPGVILIVGLGLLATYTGYNIGLMRERYPHIQNLADAGEILFGPFGRELFGTGQFLFCIFVMGSHILTFRVMMNTITDHGTCSIVFSLVGMLLSLALSVPRTMRGMTWISFFSFLSIFSAVLITMISVGVQEHPGRIVEATVQTNLYTGFQAVSNIVFAYCAHVAFFGLIAEMEKPQDFKKSLFMLQGFEICLYLTAAVVIYFFVGKGVNSPALISAGPLMKKVAFGIAIPTIVGAGVVNGHIGLKYIYFRLTAKSDLMHQNNWKSVGLWLGLGVTCWVVAWIIAEAIPVFQDLNGLISALFASWFSYGLSGVYWLHLNAGQWFVSPRKIALTVLNFSIIIFGAALCGLGLYASGTAIHNDTGSSPFSCSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BP82</accession>
    <name>A0A9X0BP82_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788077.1">
        <property type="nucleotide sequence ID" value="XM_056937278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BP82"/>
    <dbReference type="GeneID" id="81627527"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="78" mass="8960" checksum="92C7B693608AFD9A" modified="2023-11-08" version="1">MTFAASVTIERGSCSRGRSRPLQTPALVEVPAPYEEKRDGGSFVLSARAKYKRTMRRDSESTHTSHRVLFRRRVMFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BPH2</accession>
    <name>A0A9X0BPH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_007585</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787985.1">
        <property type="nucleotide sequence ID" value="XM_056937186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BPH2"/>
    <dbReference type="GeneID" id="81627435"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048538">
        <property type="entry name" value="Rrn7_cyclin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048540">
        <property type="entry name" value="Rrn7_cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576:SF2">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20645">
        <property type="entry name" value="Rrn7_cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20644">
        <property type="entry name" value="Rrn7_cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Rrn7/TAF1B N-terminal cyclin" evidence="10">
        <location>
            <begin position="24"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Rrn7/TAF1B C-terminal cyclin" evidence="11">
        <location>
            <begin position="146"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5477441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="478" mass="54871" checksum="E4B93FAD012A9B58" modified="2023-11-08" version="1">MASQSNSRYELCQVDLRISTHTRKAIVRDLWALRLQDFTLRINATIDDEDDSDRELFSSQPETDSSDDLGFKSHSGRYLTWPRLLDSLGLCYLAAVLMRLPVSVSDFHRLVIRQDVPYIRVARLIPFEMRDKLPPELLARLEVHQLPRLESLHRAFVDLALQYRKRFEITVPPLNAPILLYRHLRRLALPIDVYEMVQFLKSVVGFNFAFDSGGSSAKLKRALDLPELQIMTLIVIATKLLFPFDDLARVPATAKEPATQAMDWAVWARVQAHFTSREQSHGTITKEEAIRLTEKDVLNMMPRQLDEYMDWYESNWLDPFRVTNPVADMFPTARTAKGPDLPQDVQPSGPLADTGPQEALYSLLQTVMQGLKMNEPNPDLDENDRRPGSWYWRYRWEAQLPETAKQFYELAAQLAAVSLSTLLRAVSVTEYRIVKTVEDKRRADYFSQALELDMDGHGDDESIDGMDNLDEQLTGLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSU4</accession>
    <name>A0A9X0BSU4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_007011</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788547.1">
        <property type="nucleotide sequence ID" value="XM_056936612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSU4"/>
    <dbReference type="GeneID" id="81626861"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="613"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="9">
        <location>
            <begin position="74"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="693"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="763"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="868"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="913"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="979"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="698"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="763"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="930"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1019"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1045"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1080"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1100"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5481117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1132" mass="123242" checksum="FAA3073CB070F038" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSU7</accession>
    <name>A0A9X0BSU7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear distribution protein nudF</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Lissencephaly-1 homolog</fullName>
            <shortName evidence="11">LIS-1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">nudF</name>
        <name evidence="11" type="synonym">lis1</name>
        <name evidence="15" type="ORF">N7539_006409</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Self-associates. Interacts with nudE and dynein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
            <location evidence="11">Spindle pole</location>
        </subcellularLocation>
        <text evidence="11">Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">Dimerization mediated by the LisH domain may be required to activate dynein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the WD repeat LIS1/nudF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSU7"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051012">
        <property type="term" value="P:microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000342">
        <property type="entry name" value="Nuclear distribution protein PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.30:FF:000002">
        <property type="entry name" value="Platelet-activating factor acetylhydrolase ib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03141">
        <property type="entry name" value="lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017252">
        <property type="entry name" value="Dynein_regulator_LIS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037190">
        <property type="entry name" value="LIS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056795">
        <property type="entry name" value="PAC1-like_LisH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24951">
        <property type="entry name" value="LisH_PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037647">
        <property type="entry name" value="Dynein_regulator_Lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109925">
        <property type="entry name" value="Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <keyword evidence="3 12" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PAC1-like LisH-like dimerisation" evidence="14">
        <location>
            <begin position="8"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="198"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="248"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="352"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5482963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="462" mass="50486" checksum="9A6D3F23287880EE" modified="2023-11-08" version="1">MSQLLTARQAEELHKAMIAYLTAANLPQTCAALREELGDSVSVEDSTLKKYEGLLEKKWTSVVRLQKKIMDLETRCASLQTELDTATPTSLSRRNQDPVSWLPRDPARHDLESHREAVNCVAFHPIFSSLASGSEDSTIKIWDWELGELERTIKGHTRAVLDVDYGGPRGGTLLASCSSDLTIKLFDPADEYKNIRTLPGHDHSVSAVRFIPSGAAGSPMSGNLLVSASRDMTLRIWDVTTGYCVKTLHGHSGWVRDVAPSPDGRFLFSAGEDQVPRLWDISSGEPKATFLGHEHVVTCVAFAPTTSYQHLAPLAGLKKPPPSSSSAEFVATGSRDKTIRLWDARGNLVKTLVGHDNWVRGLVFHPGGKFLLSVADDKTLRCWDLTQECKCVRTIKAHDHFVSSIRWAPSLIKESHANGTAGANGEGQSSTAKDDPNAAHKMSIRCVLATGSVDKKVRVFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BT01</accession>
    <name>A0A9X0BT01_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium-binding protein NCS-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_006513</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789039.1">
        <property type="nucleotide sequence ID" value="XM_056936115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BT01"/>
    <dbReference type="GeneID" id="81626364"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5483067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="190" mass="21965" checksum="671B00F51E6D7CCA" modified="2023-11-08" version="1">MGKSQSKLSPAQLDELQKSTHFDKKELQQWYKGFLKDCPSGTLTKEEFQKIYRQFFPFGDPSSFANYVFRVFDSDNSGMIDFKEFICALSVTSRGKMEDKLDWAFQLYDIDGDGKITYDEMLAIVEAIYKMVGSMVKLPEDEDTPEKRVRKIFRMMDKDENGSLDIEEFKEGSKRDETIVSALSLYDGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BT26</accession>
    <name>A0A9X0BT26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_006261</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788787.1">
        <property type="nucleotide sequence ID" value="XM_056935863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BT26"/>
    <dbReference type="GeneID" id="81626112"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019680">
        <property type="entry name" value="Mediator_Med1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10744">
        <property type="entry name" value="Med1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med1" evidence="9">
        <location>
            <begin position="136"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="553"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5482815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="747" mass="82509" checksum="B3B976024AA4C27C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BU51</accession>
    <name>A0A9X0BU51_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_005947</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789421.1">
        <property type="nucleotide sequence ID" value="XM_056935549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BU51"/>
    <dbReference type="GeneID" id="81625798"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF149">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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        <location>
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    </feature>
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        <location>
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        <location>
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        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        <location>
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    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5485310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="758" mass="82864" checksum="345548FE6DA15D3B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BV72</accession>
    <name>A0A9X0BV72_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790380.1">
        <property type="nucleotide sequence ID" value="XM_056935186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BV72"/>
    <dbReference type="GeneID" id="81625435"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="44479" checksum="69C0BEB819D8BAB7" modified="2023-11-08" version="1">MPFTRSGKADHMQGKRPPRKEKRQLVRWDQDLDNLLLLTIQAACNQTGVKIPWKEVAEIMGTKFTEGAIVQHLSKLRIRREAAGQRVPPPLRRSVPAAANTPATKKGPKDKYNKTIDPNESYEVYEDEELSDDYGSLEDDEEVSDEEDEAHEQIESKRLKTGRESFSGVKMSNKSRPKQKNTKAKRGDTLFVSQGDSEKEYESSDDDGEDSAVETEREIERQKAIEQCANHLRQLKAAKSTPSPRPSRITKLPLGGSLKYRAGSANANPTPTLPTSSATESSYPIYMSNDPAIVNVPPTGFSPAPSGQISGSLPESQPAGRTWPGITPALGGRLLAPHEYTWSPHAPAFASGRPSAPINTGTAPSAPFGSPQGAVTLGSWEPYPEKPPAHRNSSMTEEDEEDEEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BVB3</accession>
    <name>A0A9X0BVB3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790259.1">
        <property type="nucleotide sequence ID" value="XM_056935065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BVB3"/>
    <dbReference type="GeneID" id="81625314"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="150" mass="16630" checksum="CEEA366E0C144890" modified="2023-11-08" version="1">MATAKGGVNFVRIFFYSGNTISAERKKSLVALAYATARDQLLAPKAILIRSDMHNTTTSKSGHVMDPKGWHGTFAFKASDQLLREYHVASHGYTNGKEDFTLKEATHTSEKADNTRRGGPLSDKVVWPPEEFLEEYKESPIAYSHLPGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXI4</accession>
    <name>A0A9X0BXI4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Malonate--CoA ligase ACSF3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_003409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790552.1">
        <property type="nucleotide sequence ID" value="XM_056933011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXI4"/>
    <dbReference type="GeneID" id="81623260"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05941">
        <property type="entry name" value="MCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF15">
        <property type="entry name" value="AMP BINDING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="437"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5488519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="526" mass="58087" checksum="FC8666148E249A25" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXS8</accession>
    <name>A0A9X0BXS8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_004006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791149.1">
        <property type="nucleotide sequence ID" value="XM_056933608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXS8"/>
    <dbReference type="GeneID" id="81623857"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000005">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000003">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="120"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5489116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="239" mass="26819" checksum="C9E6CD43C604D752" modified="2023-11-08" version="1" fragment="single">ARVVHESKTVKKDHKEQTRRLYANIRECVEEYDHLFVFSVDNMRNTYLKDVRAEFGDSRLFFGKTKVMAVALGTAPENEAADNLHKLCPYLTGAVGLLFTSRPVDSVIQYFDNFHPSDFARAGTVATRSFTLPNGLVTARGGEIPADQDEPVSHTIEPALRKLGIPTRLVKGKVMLELTEGQEGYPICRKGETLDSRQTTILKMFGITSSEFKVDLKAMWTRETGEIKILEEGDMETDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXT7</accession>
    <name>A0A9X0BXT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">penicillopepsin</fullName>
            <ecNumber evidence="6">3.4.23.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_003990</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates. The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site. Shows a broad primary substrate specificity. Favors hydrophobic residues at the P1 and P1' positions, but can also activate trypsinogen and hydrolyze the B chain of insulin between positions 'Gly-20' and 'Glu-21'.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving 20-Gly-|-Glu-21 in the B chain of insulin. Clots milk, and activates trypsinogen.</text>
            <dbReference type="EC" id="3.4.23.20"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.20" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791133.1">
        <property type="nucleotide sequence ID" value="XM_056933592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXT7"/>
    <dbReference type="GeneID" id="81623841"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000024">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF2">
        <property type="entry name" value="ASPERGILLOPEPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 14" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040882270" description="penicillopepsin" evidence="16">
        <location>
            <begin position="21"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="17">
        <location>
            <begin position="92"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5489100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="397" mass="41188" checksum="9BB2717F4EA74773" modified="2023-11-08" version="1">MVVFSKFTAVLASLAAVSSAMPTGGSPKAESPKTRFSIKQTARPASKPKTVNLPAMYAATIAKYGGKVPDSVKAAASRGSAITTPTNNDEEYLTPVTVGGSTLNLDFDTGSADLWVFSSELPSSESQGHDLYSPSPNAQKLSGYSWSISYGDGSNASGDVYEDTVSVGGVTASRQAVEAAQSVSQQFVSNVGNDGLLGLAFSSINTVQPQAQTTFFDTVQSQLDSPLFAVTLKHNAPGTYDFGFIDSSKYTGQLAFTPVDNSQGFWSFNADGYSVGYVQGAGITGIADTGTTLLLLDDSVVYDYYSQVSGAQSDSSAGGITIPCDAQLPDFVVTINGYDAVVPGSLINYAPLSGNTCFGGIQSNSGIGFSIFGDIFLKSQYVVFDASGPQLGFAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY29</accession>
    <name>A0A9X0BY29_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tubulin-specific chaperone D C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_003843</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790986.1">
        <property type="nucleotide sequence ID" value="XM_056933445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BY29"/>
    <dbReference type="GeneID" id="81623694"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="3">
        <location>
            <begin position="362"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="3">
        <location>
            <begin position="458"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D C-terminal" evidence="2">
        <location>
            <begin position="949"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5488953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1203" mass="133434" checksum="BA4AF515A0EB6BEB" modified="2023-11-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY60</accession>
    <name>A0A9X0BY60_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear pore complex subunit Nup192</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_003933</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791076.1">
        <property type="nucleotide sequence ID" value="XM_056933535.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81623784"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1670"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1682"/>
            <end position="1692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5489043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1692" mass="188436" checksum="8874311621D76C24" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY90</accession>
    <name>A0A9X0BY90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791317.1">
        <property type="nucleotide sequence ID" value="XM_056933776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BY90"/>
    <dbReference type="GeneID" id="81624025"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="231" mass="25674" checksum="143800EDF9B158B6" modified="2023-11-08" version="1">MAPFRNFLGRKNQPLTPTLEVTDDTHLTRNAHPSLVPIASRKSTDSQHPPEYKLSVVNDSGVYLPPSPPEKSSFWGRVPGSSRTENHRDLVNENEPFSISRESFDSYRRSFDISARSPVYYADAAPSRSSLDSRFSRPSLQSGSFERPERMEEESGFEEVGLHDEPKPKKRSLFSRFNDSSNDSQPPTPKSSTSFGFHMPGRKRGQSGTAAELGSVKTPTSTVTPALQNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYB3</accession>
    <name>A0A9X0BYB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">pectin lyase</fullName>
            <ecNumber evidence="12">4.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_004098</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.10" evidence="12"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791241.1">
        <property type="nucleotide sequence ID" value="XM_056933700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYB3"/>
    <dbReference type="GeneID" id="81623949"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047490">
        <property type="term" value="F:pectin lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000003">
        <property type="entry name" value="Pectin lyase F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF16">
        <property type="entry name" value="PECTIN LYASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040829184" description="pectin lyase" evidence="14">
        <location>
            <begin position="17"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="15">
        <location>
            <begin position="91"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
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        </source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00039082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5489208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="377" mass="39646" checksum="9573C8B1CA58C428" modified="2023-11-08" version="1">MKFIALLAAIAAQAAAISVSGAAEGFAKGVTGGGSASPVYPQSTSELVSYLGDSQPRVIVLTKTFDFRGTEGTAQSSGCSPWGTNPKCQIAINQNNWCKNYEPNAPTVSSITYDKAGVLGITVASHKTIIGQGSAGVIKGKGLRIVSGANNIIIQNVAITDINPQYVWGGDAITIDNSDMVWIDHVTTARIGRQHIVLGTSASKRVTISNSFIDGRTDWSATCNGYHYWAIYLDGNNDYVTMKGNYIYHTSGRSPKVQGNTLLHAVNNYWYDNGGHAFEIGSGGYVLAEGNVFQNVPNINDVTMTGKLFTSPSTSANQACGSALGRACQLNGYGSSGQFNSADTSFFSKFNGQNIASASPYTSVVASVNAKAGQGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYJ8</accession>
    <name>A0A9X0BYJ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791662.1">
        <property type="nucleotide sequence ID" value="XM_056934121.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81624370"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF3">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="141"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="370"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="452"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="723" mass="80680" checksum="35CAA7AB1D337AD9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYS6</accession>
    <name>A0A9X0BYS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mucin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791585.1">
        <property type="nucleotide sequence ID" value="XM_056934044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYS6"/>
    <dbReference type="GeneID" id="81624293"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="59804" checksum="350B593E1D0313D6" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYY0</accession>
    <name>A0A9X0BYY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphoketolase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_002767</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792329.1">
        <property type="nucleotide sequence ID" value="XM_056932370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYY0"/>
    <dbReference type="GeneID" id="81622619"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF32">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5491200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="570" mass="63541" checksum="F34F23238DDDA0FD" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ18</accession>
    <name>A0A9X0BZ18_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="7">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_002621</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="7"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792183.1">
        <property type="nucleotide sequence ID" value="XM_056932224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ18"/>
    <dbReference type="GeneID" id="81622473"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000045">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.270:FF:000002">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="14">
        <location>
            <begin position="33"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5491054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="643" mass="70700" checksum="CD615FF5C94602C2" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ56</accession>
    <name>A0A9X0BZ56_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_002726</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPI-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792288.1">
        <property type="nucleotide sequence ID" value="XM_056932329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ56"/>
    <dbReference type="GeneID" id="81622578"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000260">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="11">
        <location>
            <begin position="22"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="12">
        <location>
            <begin position="680"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="13">
        <location>
            <begin position="821"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
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        </source>
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        </source>
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        </source>
    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">IBT 30728</strain>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
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    </gene>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5491549.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0A8</accession>
    <name>A0A9X0C0A8_9EURO</name>
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        </submittedName>
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    </gene>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <location>
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            <end position="90"/>
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            <end position="156"/>
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        <location>
            <begin position="216"/>
            <end position="240"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="KAJ5492910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="613" mass="67245" checksum="93848C7246BC234D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0H4</accession>
    <name>A0A9X0C0H4_9EURO</name>
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        <recommendedName>
            <fullName evidence="4">Calcofluor white hypersensitive protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">N7539_001730</name>
    </gene>
    <organism evidence="2 3">
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    </organism>
    <reference evidence="2" key="1">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="110"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="14545" checksum="EBD9BFE888217253" modified="2023-11-08" version="1">MSKPRTGLYLGLAAAGAGGYYLYRAGGDPQIAKNEMKIDANKAREKLPTSDHTAEKTAKNAGADVGEAIDNARLKANLTLDNSKQHLEEGKKQLENYGKEARDQFNSTVDKVDRTVEQKAAEAKGTVSGWFSGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2W4</accession>
    <name>A0A9X0C2W4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="4">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">COQ5</name>
        <name evidence="5" type="ORF">N7539_001012</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2W4"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000133">
        <property type="entry name" value="2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5495896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="314" mass="35169" checksum="783EF970C94D1BD7" modified="2023-11-08" version="1">MSARSAWRALHYSAKRRVVQPTSPYRCFSCTRQAFDQAKPDQQRMTHFGFTNVPESEKESRVGAVFSSVASSYDNMNDLMSLGIHRLWKDHFVRSLNPGTPVANRPADAKDQGWNILDIAGGTGDIAFRMLDHATNINHDMQTRVTISDINAEMLAEGRKRSTATPYYNTSRLSFVQANAQDMPHIPSDSVDLYTVVFGIRNFTDKQAALNEAFRVLKPGGVFACMEFSKVENPVFDAVYKRWNFGAIPLIGQIVAGDRDSYQYLVESIERFPSQEEFRGMIQKAGFEIPGKGYENLTGGIAAIHKGIKPISRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2Z7</accession>
    <name>A0A9X0C2Z7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calcineurin binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794999.1">
        <property type="nucleotide sequence ID" value="XM_056930706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2Z7"/>
    <dbReference type="GeneID" id="81620955"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000503">
        <property type="entry name" value="Calcineurin binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF14">
        <property type="entry name" value="PROTEIN SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32039" checksum="85674D67522A2A33" modified="2023-11-08" version="1">MAEFISPSPSSQTSPAFAAAHSRARPSLSIDITSLPPLSQPTPPSNTLIITELNDLVLFQPSSLESIRNQITVVARLNSFSPLPSFRRIICSFHSDEDAIAVRKMLEGTRLLNRNVRPRIYFGEPTPILSQEETQRKQLLEAPQLDKLFFISPPPSPPHGWQMRNEDPPNKEVHASDLATALANLRTDPSSDSMNVDPATPVSISFDQRTGSFPMAGAPQQQRSRSSTIIFHPEDHGHSPNLPAVMVEDTSLPVDEDMDMELDAQWSPVEMFINKTPPKTARPPVELMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKE4</accession>
    <name>A0A9W9WKE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Deoxyhypusine synthase</fullName>
            <ecNumber evidence="6">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_009516</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785606.1">
        <property type="nucleotide sequence ID" value="XM_056939111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKE4"/>
    <dbReference type="GeneID" id="81629361"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000003">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5466560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="367" mass="39811" checksum="73EFCBFE776C3265" modified="2023-11-08" version="1">MSKSAPPTSAIDSVLVASHPVPQDAQVVRGVDFDQYQGRDITVAEMIENMTHMGFQGSAVAEAAQIINEMRAFRHPESGEKTTIFLGFTSNLISSGLRDTLRYLVKHKHVSAIVTTAGGVEEDLIKCLAPTYMGSFSTPGAGLRAKGLNRIGNLLVPNNNYCAFEDWVVPILDRMLEEQEGAKKKARETGDEEDELHWTPSRITERLGHEINNESSVLYWAAKNGIPVFCPALTDGSLGDMLYFHTFKSSPQRLRVDIVDDVRRINTMAVRAARAGMIILGGGVVKHHIANACLMRNGAEHAVYVNTAQEFDGSDAGARPDEAVSWGKIKADARAVKVYAEATVVFPLIVAASFAKSGTATQAPAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKI7</accession>
    <name>A0A9W9WKI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_009468</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785785.1">
        <property type="nucleotide sequence ID" value="XM_056939063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKI7"/>
    <dbReference type="GeneID" id="81629313"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="217"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5466739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="253" mass="28592" checksum="E3881DF64CE3940D" modified="2023-11-08" version="1">MDFFWNAPPVARTLTAATLIESLLVHGRIIGVRQLAWAPSLIFWKFPPQLWRIGTAFCLTRPDLEFLFDLYNLWRYSSALELESIRFPQPGDFFIYLLFVSTVIQLTAGLYLGGYFFLTSLTMALIWTYAQEKRGTKVTFFVITIPVIYLPAVMLCLTLVRAGWGGVLYESTGILAAHLYHFLTHIYPTYGGGRNYISTPLFVQRFFYKHTPTTSRPYGTPYRPAPSSASQGRASGTDAGARWGSWGSGRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKW2</accession>
    <name>A0A9W9WKW2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_008919</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785891.1">
        <property type="nucleotide sequence ID" value="XM_056938514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKW2"/>
    <dbReference type="GeneID" id="81628764"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14136">
        <property type="entry name" value="STKc_SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000409">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000076">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="116"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="24"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="276"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5469301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="584" mass="64654" checksum="DC2C52F58B87E383" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKX0</accession>
    <name>A0A9W9WKX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase-like superfamily-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_008984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785956.1">
        <property type="nucleotide sequence ID" value="XM_056938579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKX0"/>
    <dbReference type="GeneID" id="81628829"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="2">
        <location>
            <begin position="22"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="3">
        <location>
            <begin position="186"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5469366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="312" mass="34255" checksum="277BC8940D281852" modified="2023-11-08" version="1">MEQAVELTSVPTKPNTFTNVIPPWSFPGSFGVFGGTTLAHCLMAAQKSISKNYVAHSLHCSFLSRADPSLQIEYQVENTRDGKSFATRTVRAIQKESLIAVAIVSFVAVGITAADATAFRGTNSFEHSHKIPQGLIPPEKASIEGEGIPGPLEVRGGQSLNRGFDSCVLCVCFTDESAISGISPNPVHSLIRYWIRAKRPILKHNLHVHLAALAWMSDAYFIAAAVHAYDELSRRSDKEIAKVASLSHVIYFHQPDAVRADEWMCSERESSWAGNDRAFVAQRIWNREGVLVATCVQEGLLRIREPAAKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL33</accession>
    <name>A0A9W9WL33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_009431</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785748.1">
        <property type="nucleotide sequence ID" value="XM_056939026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL33"/>
    <dbReference type="GeneID" id="81629276"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="8">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="7">
        <location>
            <begin position="110"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5466702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="159" mass="18238" checksum="FF120A5F04AED745" modified="2023-11-08" version="1">MSSQITLTSSDGVDISVDRTVAERSILIKNMLEDLGDSGEPIPIPNVNEAVLKKVIEWCEHHKNDPVTATDDDDNRRKTTDIDEWDQKFMQVDQEMLFEIILAANYLDIKALLDVGCKTVANMIKGKSPEEIRKTFNIQNDFTPEEEDQIRRENEWAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLL9</accession>
    <name>A0A9W9WLL9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786252.1">
        <property type="nucleotide sequence ID" value="XM_056938875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLL9"/>
    <dbReference type="GeneID" id="81629125"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007008">
        <property type="term" value="P:outer mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035195">
        <property type="entry name" value="Emr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17237">
        <property type="entry name" value="Emr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5469662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="116" mass="12621" checksum="43A8FFD9FEC37FF9" modified="2023-11-08" version="1">MAGSRPSRVVSALVSTATSAAPQTSFSPELFPNYGSSGCLYSEVQFNIECQGETFGNIPAQMANLPNLRRLFVEARTEVEENEYSRTAFYNLVLFISSVAIFSLAAQRMSGPKAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQH7</accession>
    <name>A0A9W9WQH7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GED domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_008769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786372.1">
        <property type="nucleotide sequence ID" value="XM_056938364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQH7"/>
    <dbReference type="GeneID" id="81628614"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="4">
        <location>
            <begin position="37"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="3">
        <location>
            <begin position="596"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5471826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="78397" checksum="222A35B3363FEE65" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WRG0</accession>
    <name>A0A9W9WRG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA-directed DNA polymerase from mobile element jockey</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786697.1">
        <property type="nucleotide sequence ID" value="XM_056938315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WRG0"/>
    <dbReference type="GeneID" id="81628565"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5472151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="217" mass="24202" checksum="E9B9098B55A12268" modified="2023-11-08" version="1">MGKSCTLTVYAAELKGLALALQIILDTPPAYDPLNKRAYTLVEAVRALDEARSQGWEVQFRWIPAYIRVSGNEAADQAAKEAAGVDPNARANAEPLLEPDSLRTLTATTKSTIRRAMRNEWDQAWEKCKHGRELLRLGVRPGKAILDTHAGTVRHILLDCRNWVEERQRMWAGKSPCIDIKRILCNPPMAVQAAKMILRTGLLGQFQAVPSTVLKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTB4</accession>
    <name>A0A9W9WTB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alkaline phytoceramidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_008180</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786872.1">
        <property type="nucleotide sequence ID" value="XM_056937780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTB4"/>
    <dbReference type="GeneID" id="81628030"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF1">
        <property type="entry name" value="ALKALINE PHYTOCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5475114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36900" checksum="254240559C78AEF5" modified="2023-11-08" version="1">MQSNSVDPFWGPATSYLNFCEEVNHPLVVLCSLIWSSQDHFAYIEIDIKDYAITRYIAEFINTLSSFVFGMSTPRYADLANLYDVLTAMLSLVLFGVYGLRQLREKNAASYRSLLYFGLIGVGVCSAGYHMTLKYHTQMSDELSMHLLTTPLLYRILTFQASSKKTRIVGIVLSLLFVTVMFFHMVLNEFLLHAVTFGTAVLTIAVRTSKITAQQVTDPYMKKKLRNISYFGIFCFAFGFFVWLIDGLACGLLKDTRHAIGLPLAFLTELHGWWHILTAIGGYVAVALVDLVTANELNKGDPIEELAWPIPTAARYIQEWVGPKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUA1</accession>
    <name>A0A9W9WUA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pal1 cell morphology protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787390.1">
        <property type="nucleotide sequence ID" value="XM_056937525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUA1"/>
    <dbReference type="GeneID" id="81627774"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF2">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="54455" checksum="106912B864E7CF3E" modified="2023-11-08" version="1">MDHHYKLDQMSSTGPNFGSNNPFRNRALSPDTGAPSANPRPERPRSTNPFLDDSEATSPRSGPGMAGATNIFSPVEKHDMTTNTRELFENLSIKPGTQGPPRSGPDAGHRGSGSGSRPRPPRERPERRPVDGRLDGRFKDPKDPFDIFADPPGKASGSGSRDYSSRRPRRNSESSVMDRAPRLLDDDDEKRRRERRREREARHREGRDSKSRPTRKDRRLDIIDKLDVTSIYGTGMFHHDGPFDACNPHRNRKGARTAPMQAFPKDSSNMALGGAGPNNSNIDLNLFHGRMEEAHNDFSFPVAAPKVTADTVPFDSAARIDPVHGQESMGLGTSTFLDGAPASRSAIARRQSEHDDTGAGGLQRKKSLAQRLRGKSGTGRPSLSSPTRNGLPSPNPAPINSSHSASSRVGERNPFFQDYDEEYDKKAARIHEARLEDDGGRERSSSSPKQPTNLERKTTNDRGYDETKLSAGGGGFLNRMKSLRKPRPVRRTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUS4</accession>
    <name>A0A9W9WUS4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_007258</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787658.1">
        <property type="nucleotide sequence ID" value="XM_056936859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUS4"/>
    <dbReference type="GeneID" id="81627108"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000007">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 18" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="16">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Tr-type G" evidence="17">
        <location>
            <begin position="475"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="257"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="768"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="276"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5477114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="997" mass="110750" checksum="1F7FBF79E9E1BEC1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUX4</accession>
    <name>A0A9W9WUX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein P1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">60S acidic ribosomal protein P1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_007307</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787707.1">
        <property type="nucleotide sequence ID" value="XM_056936908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUX4"/>
    <dbReference type="GeneID" id="81627157"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001859">
        <property type="entry name" value="Ribosomal_P1/P2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00456">
        <property type="entry name" value="RIBOSOMALP2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5477163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="109" mass="10966" checksum="C008E23D95488507" modified="2023-11-08" version="1">MSTAELAVSYAALILADDGIEITADKIQTILTAAKVQEVEPIWASIFAKALEGKDVKDLLTNVGSAGPAASAGPAAAAGGAAAAEAAPAEEKAEEKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUY8</accession>
    <name>A0A9W9WUY8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787735.1">
        <property type="nucleotide sequence ID" value="XM_056936936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUY8"/>
    <dbReference type="GeneID" id="81627185"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01443">
        <property type="entry name" value="Cdc25_Acr2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF50">
        <property type="entry name" value="REDUCTASE (ARC2), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13400)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="47"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="160" mass="17405" checksum="A703B48DEC59CC75" modified="2023-11-08" version="1">MAESTATTTSTTSAELPWHAAYPAPQSAVRSLPRNELLQWFQTGKQPGQDFVLVDVRRTDFEGGTIQGSINLPAQSLYPTLPAVYSLLSQTGVKHVIWYCGSSNGRGPRTANWFADYLALKQDTSMESLILEGGIKGWAAAGPEYTALMVGYDSSAWTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUZ0</accession>
    <name>A0A9W9WUZ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteinase inhibitor, propeptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5476972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787516.1">
        <property type="nucleotide sequence ID" value="XM_056936717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUZ0"/>
    <dbReference type="GeneID" id="81626966"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052471">
        <property type="entry name" value="PBI_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288:SF1">
        <property type="entry name" value="INHIBITOR I9 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040969409" description="Proteinase inhibitor, propeptide" evidence="2">
        <location>
            <begin position="18"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5476972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="10830" checksum="12F5AC1CB35B8D0E" modified="2023-11-08" version="1">MKFFLIAMLSLLPVALAAKSLKSVVISFPKGTPSSVVDKAKDAIVASGGVITHEYHLFPGFSAEAPVNTLQTLSTQDATYKPNIEVDKIVTANGEYAGETNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV37</accession>
    <name>A0A9W9WV37_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nitrate reductase [NADPH]</fullName>
            <ecNumber evidence="7">1.7.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">N7539_007438</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>nitrite + NADP(+) + H2O = nitrate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19061"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.3" evidence="7"/>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787838.1">
        <property type="nucleotide sequence ID" value="XM_056937039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV37"/>
    <dbReference type="GeneID" id="81627288"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050464">
        <property type="term" value="F:nitrate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000003">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="14" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="685"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="796"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="132"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ5477294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1057" mass="120949" checksum="A287DD16063B0B8F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVB4</accession>
    <name>A0A9W9WVB4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_007552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787952.1">
        <property type="nucleotide sequence ID" value="XM_056937153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVB4"/>
    <dbReference type="GeneID" id="81627402"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5477408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="75" mass="8374" checksum="A8515EA86CBCD032" modified="2023-11-08" version="1">MHDISSSGFTAYGRSSTPLSEIKYMPQRNCPLPRPWNSISEVPDGEHCRDMSIVPPELRNIMIQFASTGPHMAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVH7</accession>
    <name>A0A9W9WVH7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_007605</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788005.1">
        <property type="nucleotide sequence ID" value="XM_056937206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVH7"/>
    <dbReference type="GeneID" id="81627455"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14478">
        <property type="entry name" value="SPX_PHO87_PHO90_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF92">
        <property type="entry name" value="LOW-AFFINITY PHOSPHATE TRANSPORTER PHO91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="589"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="634"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="718"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="762"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="786"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="814"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="853"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="898"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="948"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="128"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5477461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="971" mass="106709" checksum="D7AC8288DB0523E6" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1P4</accession>
    <name>A0A9W9X1P4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ornithine decarboxylase</fullName>
            <ecNumber evidence="10">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">N7539_006707</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="10"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788243.1">
        <property type="nucleotide sequence ID" value="XM_056936308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1P4"/>
    <dbReference type="GeneID" id="81626557"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.37.10:FF:000010">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="6 15" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 C-terminal" evidence="17">
        <location>
            <begin position="71"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="18">
        <location>
            <begin position="77"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="15">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ5480813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="449" mass="49378" checksum="CEEF59479BA954B7" modified="2023-11-08" version="1">MAPTACVMPAAEVCAVKNDLIHHDPLGKAGKLGDELLQSELTARELVMDVLKKRASEVDTDRCEAGEEDAFYVADMGEVYRQHMRWKMNLGRVKPFYAVKCNPDPEVLRLMAQLGNGFDCASKSEIDLALQTGIDPSRIIYAQPCKTKSYLRYAAQVGVKQMTFDNADELYKIKAHFPDAELYLRILTDDSTSLCRLSMKFGASLDVAAQLLQLARELDLKVVGVSFHVGSGAEDPRAFLKAVQDARLVFDQAAAIGHELHTLDVGGGFCHDTFEKFSGILSTALETYFPPSVRIIAEPGRYYVANAFTLAANVIARRDLPDPLDPSRTAYMLYLNDGVYGNFSNIIFDHQHPVAKVLLCAADAPRSGLPSTAAGEINSYSIWGPTCDGIDVITQRIDLPGLLNTGDWLYFEEMGAYTKCSATRFNGFSDNHEVIYISSEPGASALLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X294</accession>
    <name>A0A9W9X294_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_006942</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA43 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788478.1">
        <property type="nucleotide sequence ID" value="XM_056936543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X294"/>
    <dbReference type="GeneID" id="81626792"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000004">
        <property type="entry name" value="RNA polymerase I subunit Rpa43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPA43 OB" evidence="9">
        <location>
            <begin position="169"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="368"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="392"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5481048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="446" mass="48675" checksum="25295B0147EF3313" modified="2023-11-08" version="1">MAVDAMDLDNSPRPGEVERKRKHKNKDASPSKKRKQPVQSSSASQKDQRSSTGAGAGAGATTGKASGSPFSLTTATLYLPLAPISISSTVALQSLLAEHLSPLLLTYYPPLKGVVLAYSHASISATPPTSIPRNGSSDPNPQQLTLARSADEYGVLYVYLTATFLIFRPQRGQTLEGWVNVQTEGFLGAVVFNLFSVGIEHKRLPTSWTWVPPGEDGETPENTHKDLTTDDESGAGGASPGFDAEKELFQPAPAAIDEVDIDGEAEEEEVSGGHFQSISGHTVRGNIKFRVVDIDVIPGSDRDRGFLSIEGTMLTEEEEQALLTAESQGDVLPSSFLGSAQKRNGRIIPISTSPAADAVVDVSVVEIDEPTGQDEEETESREEKVTKEKKEKKEKKEKKEKKEKKEKKDKKDKKDKKDKKDKKDKKDKKDKSESKEKKEKKEKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2S6</accession>
    <name>A0A9W9X2S6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein transport protein SEC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_006237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788763.1">
        <property type="nucleotide sequence ID" value="XM_056935839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2S6"/>
    <dbReference type="GeneID" id="81626088"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15857">
        <property type="entry name" value="SNARE_SEC9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15886">
        <property type="entry name" value="SNARE_SEC9N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000043">
        <property type="entry name" value="Protein transport protein sec9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="361"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00072549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5482791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="424" mass="45838" checksum="7F890AE5C1BC89FA" modified="2023-11-08" version="1">MGLFKKHSEDGEESSRRALFGSRSKNKSPAAASNPYAQPAYVDPYTKAKIQAGVTPPPAGYQGGTQSPAPAQGPHAIPSDNKYSANAYGNQGGYGGDRYGNGGNGNGAGASRYGTGGYGGLGNADPNDPGKTDAARNELFGGARDRTQSGQNGAPPPYSPGQGGEAGGQGGNYGGGSNEYSMATYQDRQLTAEEEEEEQIQATKQEMKFVKQGDVASTRNALRAAAMAEETGRSTLARLGAQGEMVHDAEKNLDMATVEGRVAQEKARELKALNKSMFAVHVSNPFTSASRRRERDERILNTHREERDQREGTRSEAYQTNARMDKVFRDIDREANKQQKGKKANVTERAKYQFEADSEDEAMEDEIEQNLDLLSGAAGRLNGLAKATGQELDQQNRHLERITGKSDYVDDQIAMNRAKLDRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X309</accession>
    <name>A0A9W9X309_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA damage-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Pre-mRNA-splicing factor RSE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_006458</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in pre-mRNA splicing and cell cycle control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDB1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788984.1">
        <property type="nucleotide sequence ID" value="XM_056936060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X309"/>
    <dbReference type="GeneID" id="81626309"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001143">
        <property type="entry name" value="Pre-mRNA-splicing factor rse-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000628">
        <property type="entry name" value="Pre-mRNA-splicing factor RSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000068">
        <property type="entry name" value="Pre-mRNA-splicing factor rse1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="14">
        <location>
            <begin position="19"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="15">
        <location>
            <begin position="461"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="13">
        <location>
            <begin position="854"/>
            <end position="1175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5483012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1209" mass="133663" checksum="DA8B751805F37BC0" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3A8</accession>
    <name>A0A9W9X3A8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789046.1">
        <property type="nucleotide sequence ID" value="XM_056936122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X3A8"/>
    <dbReference type="GeneID" id="81626371"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5483074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="137" mass="20349" checksum="1A11E5B598A81CC1" modified="2023-11-08" version="1">MMSFFPVKVRSAWTRRPKMKTQQVLRFRSTLTSRNITSEYHYYYYYYYYYYYYYYYYYYYYHYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYHYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYSNFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3C8</accession>
    <name>A0A9W9X3C8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable E3 ubiquitin ligase complex SCF subunit sconB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Sulfur controller B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Sulfur metabolite repression control protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_006414</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF(sconB) E3 ubiquitin ligase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788940.1">
        <property type="nucleotide sequence ID" value="XM_056936016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X3C8"/>
    <dbReference type="GeneID" id="81626265"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="12">
        <location>
            <begin position="434"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="672"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="788"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="828"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="870"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="910"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="141"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="264"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="340"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="266"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5482968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1020" mass="112352" checksum="B2197652A631C28D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X4P9</accession>
    <name>A0A9W9X4P9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thiolase-like protein type 1 additional C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_005693</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789167.1">
        <property type="nucleotide sequence ID" value="XM_056935295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X4P9"/>
    <dbReference type="GeneID" id="81625544"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040771">
        <property type="entry name" value="TLP1_add_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF139">
        <property type="entry name" value="THIOLASE-LIKE PROTEIN TYPE 1 ADDITIONAL C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18313">
        <property type="entry name" value="TLP1_add_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase-like protein type 1 additional C-terminal" evidence="4">
        <location>
            <begin position="430"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5483897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="516" mass="56033" checksum="361C1940B8206715" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X567</accession>
    <name>A0A9W9X567_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TFIID subunit TAF5 NTD2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_005777</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat TAF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789251.1">
        <property type="nucleotide sequence ID" value="XM_056935379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X567"/>
    <dbReference type="GeneID" id="81625628"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="8">
        <location>
            <begin position="127"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="493"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="520"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="562"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="604"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="654"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5483981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="760" mass="83363" checksum="EE62D5E3DF6CF4B9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X572</accession>
    <name>A0A9W9X572_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_005724</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789198.1">
        <property type="nucleotide sequence ID" value="XM_056935326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X572"/>
    <dbReference type="GeneID" id="81625575"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03488">
        <property type="entry name" value="Topoisomer_IB_N_htopoI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.10:FF:000003">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018521">
        <property type="entry name" value="TopoIB_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048045">
        <property type="entry name" value="Topoisomer_I_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00176">
        <property type="entry name" value="TOPO_IB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="10">
        <location>
            <begin position="382"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="723"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5483928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="839" mass="95339" checksum="B250469FCD8E3186" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5A8</accession>
    <name>A0A9W9X5A8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_005877</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789351.1">
        <property type="nucleotide sequence ID" value="XM_056935479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5A8"/>
    <dbReference type="GeneID" id="81625728"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000053">
        <property type="entry name" value="Putative Mitochondrial DnaJ chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="175"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="12">
        <location>
            <begin position="317"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="9">
        <location>
            <begin position="317"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="545"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5484081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="609" mass="64615" checksum="C59F45731D4E1DDB" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5K7</accession>
    <name>A0A9W9X5K7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_004767</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="8"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789563.1">
        <property type="nucleotide sequence ID" value="XM_056934369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5K7"/>
    <dbReference type="GeneID" id="81624618"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000048">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="53"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5484779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="195" mass="22016" checksum="BD1FE6242CC7ECAB" modified="2023-11-08" version="1">MTTPSFTPSTTIPELTKSIVNSTVTPVDMEDDAPLFASSLISPEIISILPTDYTIRPLRRSDYQRGYLDVLRVLTTVGDISEEQWNQRYDWIASRNDEYYMLVICDGQDQIVGTGSLIVERKFIHSLGMVGHIEDIAVEKNQQGKKLGLRIIQALDYVAEKVGCYKSILDCSEANEGFYVKCGFKRAGLEMAHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5P2</accession>
    <name>A0A9W9X5P2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789561.1">
        <property type="nucleotide sequence ID" value="XM_056934367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5P2"/>
    <dbReference type="GeneID" id="81624616"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="122"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5484777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="381" mass="43164" checksum="ECA5466471FFDAF1" modified="2023-11-08" version="1">MAQESSISGDDPALHKWRSPLILQPLHNSLPPELLLRFDPIFVEYYNKYNAGRLHTHEVPIDDFRRNPARYMISYGRANGPDVYSISEQKCPVSGGEITIRIFEPAPQVDAQYQPKKRAAYINFHGGGWVFGGLDYDHEFCKRLVHGLDGDLVAFDVDYRLAPEHPYPVPVDDCWAAFTWVRYMKLVGCFIRSHKADVYNLDVNRFAIGGASAGGHLSAVLAHLCRDENIPLRLQVLTVPICDLDSSFTFDGHFDRQNSPYPSYREMEFAPLLPVARMEFFYRYFLGVPRPAPSADDWKISPMLAPDFNNLAPALVSTAEMDPLRDEGEAYADKLRAAGNRVEKHRYLGAPHTFASLDGILEAGRQFNERVIACMKRELLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5T3</accession>
    <name>A0A9W9X5T3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_004770</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homopentamer. Forms homooligomers. Interacts with MFM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789566.1">
        <property type="nucleotide sequence ID" value="XM_056934372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5T3"/>
    <dbReference type="GeneID" id="81624621"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000005">
        <property type="entry name" value="Inner membrane magnesium transporter MRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.330:FF:000002">
        <property type="entry name" value="Inner membrane magnesium transporter mrs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="592"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="592"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5484782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="649" mass="71288" checksum="3549F4F998C8300D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X622</accession>
    <name>A0A9W9X622_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nonribosomal peptide synthase sidD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_004784</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789580.1">
        <property type="nucleotide sequence ID" value="XM_056934386.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81624635"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056896">
        <property type="entry name" value="SIDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24895">
        <property type="entry name" value="SIDD_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="714"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1482"/>
            <end position="1558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5484796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="2007" mass="221665" checksum="F8330F2FDA7CBEEA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6A8</accession>
    <name>A0A9W9X6A8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho-GTPase-activating protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_005790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789264.1">
        <property type="nucleotide sequence ID" value="XM_056935392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6A8"/>
    <dbReference type="GeneID" id="81625641"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04396">
        <property type="entry name" value="RhoGAP_fSAC7_BAG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="73"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="455"/>
        </location>
    </feature>
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        <location>
            <begin position="474"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
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            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
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            <end position="414"/>
        </location>
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        </location>
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            <begin position="434"/>
            <end position="448"/>
        </location>
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        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="506"/>
        </location>
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            <end position="577"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <end position="618"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <end position="657"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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        <location>
            <begin position="743"/>
            <end position="754"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="763"/>
            <end position="781"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
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            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
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            <dbReference type="EMBL" id="KAJ5483994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="855" mass="92560" checksum="22F5376A7715EB3A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
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    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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            <authorList>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <dbReference type="EMBL" id="KAJ5485403.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="523" mass="58897" checksum="16E8467DB6AE073D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7Z1</accession>
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            </authorList>
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    </reference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33438" checksum="9D87AFF930280E7D" modified="2023-11-08" version="1">MIHAILTDSPEFPLRNVDIIGCGSTLGNLLRFARGSPPSFRMLVEVVGSTVFLIRREKSPTETIPDIRGYGHTFPESYTSWDPSVKGSESHQRLVNYNFAGMKCVVRFEVDGFLPDLVTEDLKVQKNHASETADVDTNDLVSSIQGLMISSVSVGSASEDATVKALKVSKKGHYIPQRAVFDLKTRSIMRVHVRTLEEELPRLWIRQIPNFILAYHTLGRFNDIRVQDIREELKHWEASQQPALIKFATLLHNIVSFARGLNDCKFEIEYEEGEKILSFREPGGVVNSVLPTSLARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XD85</accession>
    <name>A0A9W9XD85_9EURO</name>
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        <recommendedName>
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        </recommendedName>
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    <organism evidence="3 4">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5489139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056933631.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:sedoheptulose-bisphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:ribose phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000022">
        <property type="entry name" value="Phosphoglycerate mutase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF15">
        <property type="entry name" value="SEDOHEPTULOSE 1,7-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="28"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="103"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26421" checksum="969556B95856F0B4" modified="2023-11-08" version="1">MPDKDAGTPRVFIYRHGQTIWSKSGQYTGKTELDLTEDGQKQVRASGKQIVGSGKLIDPAHLAHVYISPRKRAMQTFQIAFAEGDQQKLKDAKKISETERLAEWDYGQYEGLLTKEIRALRKEHGLDAEKPWDIWRDGCEGGESAQEVSDRIDDLISEIREIHRNNMHGEKHCDVVLVAHGHLLRAFTKRWLGYPMDFPLSLMLDPGAVGVLSYQHHNIDEPALMVGYGFPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XD98</accession>
    <name>A0A9W9XD98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Anditomin synthesis protein L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_003981</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
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</entry>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAJ5489213.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDY6</accession>
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        <recommendedName>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Frisvad J.C."/>
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            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488977.1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="39"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="192"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="216"/>
        </location>
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        </location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="363"/>
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            <end position="386"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="8">
        <location>
            <begin position="151"/>
            <end position="214"/>
        </location>
    </feature>
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        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="EMBL" id="KAJ5488977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="46267" checksum="A62D84BCDBDFAEBB" modified="2023-11-08" version="1">MTPATETSGPQVLGVGRRTLGMALLLLVVVLWTASNFMGSTIFADNTYPKPFFVTYINTSLFTLPFFSAIISRTWGLWRSNQLSQVDSFQSLLQHWDTYTSKHEEQDILRSPSFDDEQEDRDSPYMRPKMQGDGAKLGLRATAKLSLEFCLLWFVANYFAMACLQYTTVGSTTILTSTSGVWTLIFGAMIGVERFTLRKLLGVIASLVGIILISRVDLSSTDAGDATSVTGGASTFPHKTPTEIAVGDAMAAFSSVMYGIYTIVMKKQVGDESRVDMSMFFGMVGFFNLILLWPGFFILHWTGVEQFALPDTQRVWVIILVNSLSSLISDIAWAYAMLLTTPLVVTVGLSLTIPLSLVGQMFLQSQYASPLYWLGATIVFLSFLVVNHESQTQGQEVDYSGERGRPSSGEYESIPREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE39</accession>
    <name>A0A9W9XE39_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_004541</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791684.1">
        <property type="nucleotide sequence ID" value="XM_056934143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XE39"/>
    <dbReference type="GeneID" id="81624392"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5489651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32071" checksum="6E7F586C3B6851BE" modified="2023-11-08" version="1">MPTTHDTKQLETTNSSTNEQRHSDTIASASASASTSASASTSVSTAPQALTTSMSTKPPYSSSSTQNATFQACQACYLRKKRCVTSPNHSQCTYCFREGQDCLPRKRPTKQTNSQSRSNTNTHKAPVSTSVVTTAQDCNIRRPYLETEVPPWSAMYSMVSEALRLIPPEDSLSDPLSRKRPASERDEEDERDQTDTETDNEPEGRGTDSEEDKPSRPRKKSCSIYEAISARHVQHIPTEDKTRWTAGETWNTAATRPGPFGLIAMNGNGESAVNPKSPGTGAFLGELDALLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEE4</accession>
    <name>A0A9W9XEE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11 12">Catalase-peroxidase</fullName>
            <shortName evidence="11">CP</shortName>
            <ecNumber evidence="11 12">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">katG</name>
        <name evidence="15" type="ORF">N7539_004107</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11 12">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11 12">
            <text>H2O2 + AH2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="11">Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="11 12"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEE4"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00649">
        <property type="entry name" value="catalase_peroxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08200">
        <property type="entry name" value="catalase_peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000002">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000004">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000002">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011635">
        <property type="entry name" value="PRK15061.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555:SF0">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="HYDROPEROXIDASE I, BIFUNCTIONAL CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="7 11 12" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="4 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 11 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="14">
        <location>
            <begin position="125"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-91)" evidence="11">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5489217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="743" mass="82680" checksum="CF64991A8FCC4C27" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEE7</accession>
    <name>A0A9W9XEE7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">endo-1,3(4)-beta-glucanase</fullName>
            <ecNumber evidence="4">3.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">N7539_004659</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791802.1">
        <property type="nucleotide sequence ID" value="XM_056934261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEE7"/>
    <dbReference type="GeneID" id="81624510"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF58">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE XGEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040863944" description="endo-1,3(4)-beta-glucanase" evidence="17">
        <location>
            <begin position="27"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="18">
        <location>
            <begin position="35"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="406"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ5489769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="653" mass="66814" checksum="B05A786900372069" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEJ2</accession>
    <name>A0A9W9XEJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_004671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791814.1">
        <property type="nucleotide sequence ID" value="XM_056934273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEJ2"/>
    <dbReference type="GeneID" id="81624522"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5489781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="95" mass="10428" checksum="58548A5A68265C9C" modified="2023-11-08" version="1">MLAIKTCAATVDYDGNFTTHFSSDGLTHCRFFGEVAESLIRVLDQKGHFFDGNVFSLLIGGLKSFGEPRYTSNGNAFSNFLDLDFQGADDFVGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XER4</accession>
    <name>A0A9W9XER4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_002401</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791963.1">
        <property type="nucleotide sequence ID" value="XM_056932004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XER4"/>
    <dbReference type="GeneID" id="81622253"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5490834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="423" mass="47025" checksum="41BCF83D56FCC557" modified="2023-11-08" version="1">MTSTSIPSAQGGPLNLSQKLSQLRSNGNRRSQSSSSREPTPITPPLPSPPDLSTHQYSRPVRRILSPKDHELFLASPTYKLVLSFIFGLSDSIRGRAVTDLPQKSLESGHIVNIVSVVGRLQSLLETHPALDQGGSRFGNPAFRTFFDDVAAQSASWHTDILGMTDSSAIEEVSTYLVHSLGSQDRLDYGSGHELNFMMWLLALYQMGLLNREEFPAVVFKVYVQYLHLMRDIQSTYYLEPAGSHGVWGLDDYHFLPFLFGASQLVDHPYITPLGIHNVALLDEEGDKYIYLDQVRWVDSVKTVKGLRWHSPMLDDISGAKNWFKVESGMKKMFVKEVLGKLPIMQHFLFGSLLPASEGMGERSEGGNDDEYADGQCHDHPHGHTTTDYFGDCCGIKVPSTIAAGAEMRKRIGGSNLRPIPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XER7</accession>
    <name>A0A9W9XER7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_002338</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791900.1">
        <property type="nucleotide sequence ID" value="XM_056931941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XER7"/>
    <dbReference type="GeneID" id="81622190"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04652">
        <property type="entry name" value="LbH_eIF2B_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EIF2B subunit epsilon/gamma LbH" evidence="9">
        <location>
            <begin position="447"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5490771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="570" mass="61109" checksum="0340AC0D5209CDAA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEV8</accession>
    <name>A0A9W9XEV8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Fe-S cluster assembly protein dre2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_002556</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792118.1">
        <property type="nucleotide sequence ID" value="XM_056932159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEV8"/>
    <dbReference type="GeneID" id="81622408"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11000">
        <property type="entry name" value="Fe-S cluster assembly protein Dre2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031838">
        <property type="entry name" value="Dre2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16803">
        <property type="entry name" value="DRE2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S cluster assembly protein Dre2 N-terminal" evidence="12">
        <location>
            <begin position="27"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Anamorsin C-terminal" evidence="11">
        <location>
            <begin position="210"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site A" evidence="10">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="10">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="10">
        <location>
            <begin position="276"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="10">
        <location>
            <begin position="287"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5490989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="313" mass="33945" checksum="43355D6E8AED136C" modified="2023-11-08" version="1">MAPSMVTIDTNDDFAMDAPSQPLDAPRTLLLAPPSIAAHEEKLHALFTTFDRQSTDLQMLDRLSAGIVKLSPNIYSHVHILTDTDGSRRSEALQLLTRDVYTALVPAMKPGAKLQTQDKPLTAADSMEAIMAGLVQNETGFEKPNFEQASAVPLKLGGRKKKSPGSMGILGGFAAAEPVAPKTDRAEQDDELINEDDLLDEEDFTRPIVPPPECQPKTGRRRRACKDCTCGLADRLEAEDRERRANADKQLNVLKLQSDDLAELDFTVQGKQTGSCGSCALGDAFRCAGCPYLGLPAFKPGQEVQILNDVAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF06</accession>
    <name>A0A9W9XF06_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002607</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792169.1">
        <property type="nucleotide sequence ID" value="XM_056932210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF06"/>
    <dbReference type="GeneID" id="81622459"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003119">
        <property type="entry name" value="ABC ATPase, putative (AFU_orthologue AFUA_1G16440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000011">
        <property type="entry name" value="Putative ABC transporter ATP-binding component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF135">
        <property type="entry name" value="ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="51"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="487"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="688"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="206"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="690"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5491040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="744" mass="82761" checksum="488A4A6A7CE756D5" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF52</accession>
    <name>A0A9W9XF52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Catalase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792156.1">
        <property type="nucleotide sequence ID" value="XM_056932197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF52"/>
    <dbReference type="GeneID" id="81622446"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF13">
        <property type="entry name" value="CATALASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="1">
        <location>
            <begin position="27"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="256" mass="28890" checksum="05FD29940225787B" modified="2023-11-08" version="1">MAAHPLQAIGQAVGSMGIDPRPEQLSSLFQGANDGPAKTAARLTGVQGPGKRQDDASYFTSNEGIPLLLRTARRWEADFLKDVELKTPVLVRFSTVTLGCEFPDLARNPRGFAIKFYTGESNYDIVGLKFPVFFCRDPIQGPDVIHFRIETLRTSYSTTTRYSICSSPLLRGNHTGMMFFSDHGMPQGWTHNHGYGCHTFKWVNKDGKFVYIKYHFLAEHGQKQFTVDEATRLSGKNPDYFKRDIWRAIENGEEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFI3</accession>
    <name>A0A9W9XFI3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792454.1">
        <property type="nucleotide sequence ID" value="XM_056932495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFI3"/>
    <dbReference type="GeneID" id="81622744"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018822">
        <property type="entry name" value="UPF0646"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10336">
        <property type="entry name" value="DUF2420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="845"/>
        </location>
    </feature>
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            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="845" mass="92283" checksum="BFB82D4FF943ECDD" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFM4</accession>
    <name>A0A9W9XFM4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="8">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_002931</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="8">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="8"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792493.1">
        <property type="nucleotide sequence ID" value="XM_056932534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFM4"/>
    <dbReference type="GeneID" id="81622783"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17964">
        <property type="entry name" value="DEADc_MSS116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="114"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="357"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="616"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="616"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5491364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="672" mass="74029" checksum="DC8ABE4B9ABEF2E5" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG17</accession>
    <name>A0A9W9XG17_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI ethanolamine phosphate transferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_003162</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792723.1">
        <property type="nucleotide sequence ID" value="XM_056932764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG17"/>
    <dbReference type="GeneID" id="81623013"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051267">
        <property type="term" value="F:CP2 mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16024">
        <property type="entry name" value="GPI_EPT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000045">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037674">
        <property type="entry name" value="PIG-G_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039527">
        <property type="entry name" value="PIGG/GPI7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19316">
        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="646"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="719"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="752"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="795"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="831"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="14">
        <location>
            <begin position="434"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF19316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5491595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="860" mass="94569" checksum="9EBF08B37A839E58" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG60</accession>
    <name>A0A9W9XG60_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_002584</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792146.1">
        <property type="nucleotide sequence ID" value="XM_056932187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG60"/>
    <dbReference type="GeneID" id="81622436"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19873">
        <property type="entry name" value="DSRM_MRPL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000043">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044443">
        <property type="entry name" value="Ribosomal_mL44_DSRM_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF32">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="92"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5491017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="404" mass="44274" checksum="28427CF48A3029DB" modified="2023-11-08" version="1">MKRVQLQRWSSTVLSPRARIASRLRQHTLLAGSRGQSTASPLQTDSSPREAISEGGFEDAGMIKHVRSAHRRKDMLKYPSPPSDAALNSAKLAALHARLYLPSRLPPQTLARALVDASADSNPDFNNESLATLGHDLLTYYTTEHLLCTYPRLPLTVIFAAMYAYAGPKTLAAMAREWGVEHASLPGGEVDPGLLQFRRLAPGSDPNLVNTNTRNPRPYAAQKAWRMTVTSKIFYDDEFGDAIKGPATSGEGVTAELASATFVRAVMGAIYLHAGRPAAKRFFEQHFLSRHLDISQLFNFSQPARDLARLCARENFEPPVARIISETGRKSRHPVFVVGIFSGQDKLGEGAGASLIEARERAALAALKGWYLYSPLNVRVPSSMEEEGAAPWKPVYVDLGEVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGE0</accession>
    <name>A0A9W9XGE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleoporin NUP57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002704</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792266.1">
        <property type="nucleotide sequence ID" value="XM_056932307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGE0"/>
    <dbReference type="GeneID" id="81622556"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.490:FF:000005">
        <property type="entry name" value="Nucleoporin complex subunit 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.3600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000:SF0">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18570">
        <property type="entry name" value="Nup54_57_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="3" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup54 alpha-helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="396"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5491137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="433" mass="47155" checksum="3D79FB60B566BC90" modified="2023-11-08" version="1">MSLFGNTASASPFGNTATKPTGFGGLGGNTTGGSGSSLFGNTNSTQQQGISGSGLFGSAAAPTQTNTQTGGLFGSTTAQKPATSAFGTTTQQQTPSLFGATAQKPTTSLFGANAPQQQTQQPAAGGGLFGSTLGANNQAPQQQQQQQQQSQFGQTTMVQPQGQPQEQSLSSTLWSPGRAITGVHRTVPMQIAIVRDKWDAQIQSSPFRAYLYNHVGDDNAPFYQPSAEDDATKWEEALKKRPGSGYVPVLVKGFIDVGKRAQRQKDFLAIMQTRLHEINNCLTDLLSRHDLKISVKVADARRKHIVLSKRCLALAAKTQMLRNRGYAMDDAEEELKKKLIQLERDVFDPSLTGRGEEIWARMLAIHEHSKRLQAEMDRAGAHMTNRAEDEIDEQTMRTAKKILDDYHTQIQHLQKEMEVVKKDFEESQKSGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGS5</accession>
    <name>A0A9W9XGS5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_001453</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the TIM23 complex, at least composed of TIM23/timX, TIM17/timQ, tim50 and TIM21/timU. Interacts with preproteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793087.1">
        <property type="nucleotide sequence ID" value="XM_056931056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGS5"/>
    <dbReference type="GeneID" id="81621305"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000019">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="17">
        <location>
            <begin position="236"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="34"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="117"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5492707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="521" mass="59106" checksum="4A8574EFFEDDEBC5" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGT6</accession>
    <name>A0A9W9XGT6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7 8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_001514</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the PPP phosphatase family. PP-Z subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7 8"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793148.1">
        <property type="nucleotide sequence ID" value="XM_056931117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGT6"/>
    <dbReference type="GeneID" id="81621366"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011159">
        <property type="entry name" value="PPPtase_PPZ/Ppq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000909">
        <property type="entry name" value="PPPtase_PPZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="301"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5492768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="511" mass="55786" checksum="80D626D03159315C" modified="2023-11-08" version="1">MGQSHSKGSNGSGDALQSYPSFSKSDTKESLRSFRGSIRSKIPGARDSPRASSTALSRTESQGDKSDVGSVKSTSSRPGSASGLSSPGSENVSRTGSPEPPPSPSLSTSLKRGHKDVNAMQQSGEVDNVSDNPPTGGPPSGTVANVGESILVKRENQLNPILDFILNPPQEHAGSPGMGMGALKSIDLDDMISRLLDAGYSTKVTKTVCLKNAEITAICSATRELLLSQPALLELSAPVKIVGDVHGQYTDLIRLFEMCGFPPASNYLFLGDYVDRGKQSLETILLLFCYKLRYPENFFLLRGNHECANVTRVYGFYDECKRRCNIKIWKGFIDTFNCLPIAAIVAGKIFCVHGGLSPSLSHMDDIRGIARPTDVPDYGLLNDLLWSDPADMEEDWEPNERGVSYCFGKKVIMNFLQRHDFDLVCRAHMVVEDGYEFYQDRILVTVFSAPNYCGEFDNWGAIMSVSSELLCSFELLKPLDSTALKNHIKKGRNKRNSVLNSPPALPSAQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGV7</accession>
    <name>A0A9W9XGV7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_002944</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792506.1">
        <property type="nucleotide sequence ID" value="XM_056932547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGV7"/>
    <dbReference type="GeneID" id="81622796"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000010">
        <property type="entry name" value="GRF zinc finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CUE" evidence="6">
        <location>
            <begin position="41"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="271"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="8">
        <location>
            <begin position="425"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5491377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="55915" checksum="0E9E902DE96BFCAA" modified="2023-11-08" version="1">MDSFVVKKKRRRSTSPAEDHKVRRTEVLDTSPVPDTIGDDSTDIKIAILLSLFPELNQEHLLDLLVSCDGSVDTVSELLASGISTHTRRGSTRRATNASSLGAQTSLSSHLVHKASDGSIAPFKDGPAHRKALRTRKGQTLHLYSPDDVATYTPCTIIHNFLPPKQANALLAELLQESKYFSRYEFQLFNRTVKSPHTGSLYVSTPEEYRQHATEYRHGGTYQSNIRQATPELRAVSCKVQNAVNEAIRNRIRDFYPNGQKLKYQSPKEWKPNAAFVNCYDGPAENVGFHSDDLTYLGPRATIGSLSLGVEREFRVRRILPRDEEDENDDSAKQAVIQGNGNLPAKNASQRQGPLTSRADAQGQISIHLPHNSLLVMHAEMQEEWKHAITPAQTVSPHPIAGNRRINVTYRWFRDTLHPRSTPRCDCGEPTILRCAQRKQETRGRYMWMCQAGSTPGKESCSFFQWAEFDDDGDPVRTYKRQDEKDLVTLANFTASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGW3</accession>
    <name>A0A9W9XGW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 20">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="15">IMP dehydrogenase</shortName>
            <shortName evidence="15">IMPD</shortName>
            <shortName evidence="15">IMPDH</shortName>
            <ecNumber evidence="15 20">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">N7539_001405</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world. Does not play a role in the biosynthesis of MPA, but is involved in self resistance to MPA, since MPA acts as an inhibitor of IMP dehydrogenases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15 20">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15 20">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15 19">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="15 20"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793039.1">
        <property type="nucleotide sequence ID" value="XM_056931008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGW3"/>
    <dbReference type="GeneID" id="81621257"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15 20" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 15 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 15 17" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 15 20" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="135"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="198"/>
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        </location>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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            <begin position="342"/>
            <end position="344"/>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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        </location>
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            <dbReference type="ChEBI" id="CHEBI:29103"/>
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        </location>
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            <dbReference type="ChEBI" id="CHEBI:29103"/>
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        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
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            <dbReference type="ChEBI" id="CHEBI:29103"/>
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    <sequence length="549" mass="58119" checksum="6F5876C0A61AC372" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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                <person name="Petersen C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
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            <strain evidence="2">IBT 30728</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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</entry>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
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        <subcellularLocation>
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    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="bZIP"/>
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    </dbReference>
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        <property type="entry name" value="MEAB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
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        <location>
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            <end position="85"/>
        </location>
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            <end position="164"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5492957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="384" mass="41975" checksum="42F524E85FECBA2D" modified="2023-11-08" version="1">MVSMIETASRSDRNDAAMESLLPKSEPVPDGSISSTMSTPDAEVEPLTQDTTQTQKRKGGRKPIYATSEERKQRNRQAQAAFRERRTEYIRQLETTIKRNEESLQSLQQSHRSAADECLMLRYKNSLLERILLEKGIDVQAELRLKTGAPGSTAKPAPAPTKSAMPRPTQRHPAAIASKPEGYAISQREGTYGVASPQFQPTPTSHVSSPSHAKSPGYGFQGGGMSPVEVIGPPTGRPQLLPQPRSFTSQTSPGGISMPQTDPNEKARGPRGARIAANYYPSPFQKHYDQLEQEYDAQADLVDEDHEGSVHAPYVPGFTPQSVPSGSHNMSGYNPPAEGAHADYGNANQLMAQYEPMLDADPFGLSASMHFPTPFNYDQNNPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHD3</accession>
    <name>A0A9W9XHD3_9EURO</name>
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        <recommendedName>
            <fullName evidence="19">DNA polymerase epsilon catalytic subunit</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">N7539_001769</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 19">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterotetramer. Consists of 4 subunits: POL2, DPB2, DPB3 and DPB4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="19"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793403.1">
        <property type="nucleotide sequence ID" value="XM_056931372.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81621621"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000002">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000015">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 19" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 19" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 19" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12 19" id="KW-0408">Iron</keyword>
    <keyword evidence="13 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="21">
        <location>
            <begin position="1523"/>
            <end position="1912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1229"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1229"/>
            <end position="1240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00057054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00065544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ5493023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="2232" mass="255595" checksum="A83D2F502431E42B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHH9</accession>
    <name>A0A9W9XHH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_001466</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inhibits the enzyme activity of ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793100.1">
        <property type="nucleotide sequence ID" value="XM_056931069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHH9"/>
    <dbReference type="GeneID" id="81621318"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64602">
        <property type="entry name" value="F1 ATPase inhibitor, IF1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5492720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="100" mass="11092" checksum="5EB99DEC6975873F" modified="2023-11-08" version="1">MLRQSIVRPAVMANRSLLTRSFTVAAPRMGEGDTGAPRAGGAASSDSFTKREAAQEALYIREKEMEKLAQLRKKITDQRAHLDELESHIDSLTKDYSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHI7</accession>
    <name>A0A9W9XHI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GIT Spa2 homology (SHD) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_001396</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:actomyosin contractile ring"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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            <end position="155"/>
        </location>
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            <begin position="183"/>
            <end position="213"/>
        </location>
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            <begin position="706"/>
            <end position="721"/>
        </location>
    </feature>
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        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5492650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="869" mass="96162" checksum="D9A1B6516C809595" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHT3</accession>
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        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
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    </gene>
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        <name type="scientific">Penicillium diatomitis</name>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
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    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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        <text evidence="1 4">Belongs to the yippee family.</text>
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    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
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        </source>
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        </source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Penicillium diatomitis</name>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="AB_hydrolase_fold"/>
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        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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        <location>
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            <end position="76"/>
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        <location>
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            <end position="589"/>
        </location>
    </feature>
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        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
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        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5493296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="658" mass="74507" checksum="C855BEE11DB527BF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI26</accession>
    <name>A0A9W9XI26_9EURO</name>
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        <submittedName>
            <fullName evidence="5">UPF0619 GPI-anchored membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_002035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793669.1">
        <property type="nucleotide sequence ID" value="XM_056931638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XI26"/>
    <dbReference type="GeneID" id="81621887"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF1">
        <property type="entry name" value="UPF0619 GPI-ANCHORED MEMBRANE PROTEIN C1322.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040754509" evidence="3">
        <location>
            <begin position="24"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="22"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5493289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="240" mass="23934" checksum="4BAC2B5D61B9AAB4" modified="2023-11-08" version="1">MRFATLSMIPLAGLAVALQVTQPQKGEEFKTSDSITVKWSSVNTDVSSFNIYLVDNTVYPPVNKEIAKNVKTSDNTYTIKDLSGLTAGHGYQVNLESDSTQNTGILAQSQQFNVTSSAQSSSSSSSSSASSASSTSASASTDSSSTATSTQYSMTTGTTTGTFTTTSGTQTLTGTTTGTFTSSVATGTTTNTKAAGSGSSTSGANASGTSGTAVPTGNAAAAVRPVAALGLVAGALAFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIC3</accession>
    <name>A0A9W9XIC3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_002185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793819.1">
        <property type="nucleotide sequence ID" value="XM_056931788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIC3"/>
    <dbReference type="GeneID" id="81622037"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040747272" description="SCP domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="66"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5493439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="289" mass="32091" checksum="DC614F850E884F43" modified="2023-11-08" version="1">MPAVLQRNCTYWTLLQTLLILTYVWSNANAMPEADAVTVYNTVQRTSVVEATPTAPMPASYTSLDDFKDTMLKTTNNYRKIYQADSLSWNDELADYSRKWAKGCLWKHSDGQYGENLAFGYPNTSAAVDAWADEVKLYNFNKPTGFSEKTGHFTQLVWQSTTEVGCAAINCGFDKNKRSIRDDAFNTDDVKMDDHRIRPREADGTTRAQGWYVVCEYKPPGNIVGDNNKYFKENVKPANGSTSPSSSTSASGSQETGGAMAWTATSTRSLLWSTVVAITTVMIGTNLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIE2</accession>
    <name>A0A9W9XIE2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793565.1">
        <property type="nucleotide sequence ID" value="XM_056931534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIE2"/>
    <dbReference type="GeneID" id="81621783"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398:SF1">
        <property type="entry name" value="CSN8_PSMD8_EIF3K DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398">
        <property type="entry name" value="YALI0F14311P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="319" mass="36205" checksum="8127134722445D77" modified="2023-11-08" version="1">MQPKPPGSRLKPVADTLESVGFVSKGDKKLLNHRAQNEYFNKIKDRYVKFCVDNKSNLEAALISMPTSASGDATSNPPAALPSAKQSTVERTIPSPSSELSTLLLSLRKLREALLATAKETPVDFIQRVYAFSIQLAVRARHPPSYFPSLRYSLEKLHTRSHPLNQSDLEDVISYLILDYACRQDDMLSAFELRARARRDFAFSDQDIDQVLVALMHGNWVVFWRVRNSVDCFRQAIMDWAMAQMRRRALKAVGSAYLSVPVDWVLGECIGFDEGWTWEKLVEHENLGWEKDGENIIIRRPKTRTRLNPEAAPVNKAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIR2</accession>
    <name>A0A9W9XIR2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">mRNA 3'-end-processing protein RNA14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_001860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <text evidence="8">Nucleus and/or cytoplasm.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793494.1">
        <property type="nucleotide sequence ID" value="XM_056931463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIR2"/>
    <dbReference type="GeneID" id="81621712"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000006">
        <property type="entry name" value="CFIA complex component Rna14, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="10">
        <location>
            <begin position="277"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="666"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="887"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="143"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="194"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="920"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5493114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1042" mass="116827" checksum="20FAA0D4132135C2" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XJD2</accession>
    <name>A0A9W9XJD2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_002175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793809.1">
        <property type="nucleotide sequence ID" value="XM_056931778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XJD2"/>
    <dbReference type="GeneID" id="81622027"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5493429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="62" mass="7093" checksum="561D14E364F3115F" modified="2023-11-08" version="1">MEIDSLNGFKANSLAYDEQGYPVSSGERWKNVGVKPGLLLFRRRPTRQSETVGMQRMLVCQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLI2</accession>
    <name>A0A9W9XLI2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_000362</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GPI-anchored chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Required to reshape the cell wall at the sites where cell wall remodeling and/or cell wall maturation actively take place such as sites of conidia formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794259.1">
        <property type="nucleotide sequence ID" value="XM_056929966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLI2"/>
    <dbReference type="GeneID" id="81620215"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000145">
        <property type="entry name" value="Class III chitinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF63">
        <property type="entry name" value="III CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040774399" description="chitinase" evidence="15">
        <location>
            <begin position="23"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="16">
        <location>
            <begin position="30"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="330"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="335"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="510"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="544"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5495246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="664" mass="68598" checksum="D5A3989366E5EBCD" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLT1</accession>
    <name>A0A9W9XLT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thiamine transporter thi9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_000041</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793938.1">
        <property type="nucleotide sequence ID" value="XM_056929645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLT1"/>
    <dbReference type="GeneID" id="81619894"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIAMINE TRANSPORTER THI9"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="51"/>
            <end position="72"/>
        </location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="127"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="228"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="272"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <begin position="423"/>
            <end position="442"/>
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            <end position="510"/>
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        <location>
            <begin position="1"/>
            <end position="26"/>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5494925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="547" mass="59277" checksum="A6E2575E5A3B3153" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMJ2</accession>
    <name>A0A9W9XMJ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_000872</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056930476.1"/>
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    <dbReference type="GeneID" id="81620725"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5495756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="57357" checksum="A9C4A45955858A93" modified="2023-11-08" version="1">MPGVPSGRACDACRRQKKKVILILHHADGIYIASIDECDEAQPTCGRCLRLKIGCQGSGKRRFKFQEERPFEKRVIAGQQVKALQTAPYSASTHLIGTSRAHEKSGACWLIPSDLTGSTKQLASAFLQTIDYTTDFRWNIGWSFGPYLYEIPRRLGSNEALDRAAEALTSAHADLCSRQHGKMHTLAKYTAALRTLRAYLEDPVHAHQTNTFAAVMLLLICHTMIGQRNSVEWSGHANGAIQILKARRNLRPRDPFEAQMQLSLSGTVLFENIFNKKMELGQEEWEALIILKYDVNKPEGRLLLALSRVKDVMSRAKLLLYTGTDTTGILDELWALYIACKLDVDQLKQARMITDLSAAQHIPPGPRRDWLVRLLTVYKDRLYGLGIVITLIFNSMLQSLDLHTASLQADAYAFTEEILLLNDESECLRPVGSGYMILCLTVAWVATTDLVQRETLTRWLYEYQHDFNFSQSVSLLKDLKRNSDHLRLGVETSLSNIVDSTWNELTVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMJ5</accession>
    <name>A0A9W9XMJ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Lactoylglutathione lyase</fullName>
            <ecNumber evidence="3 13">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glyoxalase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_000884</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(R)-S-lactoylglutathione = methylglyoxal + glutathione</text>
            <dbReference type="Rhea" id="RHEA:19069"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:57474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="4.4.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glyoxalase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3 13"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794781.1">
        <property type="nucleotide sequence ID" value="XM_056930488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMJ5"/>
    <dbReference type="GeneID" id="81620737"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF77">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="15">
        <location>
            <begin position="9"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="15">
        <location>
            <begin position="166"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="373"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="480"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="480"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5495768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1183" mass="133590" checksum="EB03B64903D41AF1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMQ8</accession>
    <name>A0A9W9XMQ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleoporin Nup159/Nup146 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_000974</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794871.1">
        <property type="nucleotide sequence ID" value="XM_056930578.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81620827"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000645">
        <property type="entry name" value="Putative nuclear pore complex subunit Nup159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026054">
        <property type="entry name" value="Nucleoporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193:SF23">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup159/Nup146 N-terminal" evidence="5">
        <location>
            <begin position="52"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="460"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="537"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="657"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="704"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1384"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1447"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1476"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="460"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="573"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="735"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="800"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="825"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="950"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="992"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1050"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1480"/>
            <end position="1495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5495858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1495" mass="155412" checksum="CC1CC128F68F887D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN15</accession>
    <name>A0A9W9XN15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Complex I-75kD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_000716</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Complex I is composed of about 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794613.1">
        <property type="nucleotide sequence ID" value="XM_056930320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN15"/>
    <dbReference type="GeneID" id="81620569"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000004">
        <property type="entry name" value="NADH-quinone oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.210:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.740:FF:000033">
        <property type="entry name" value="NUAM protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09326">
        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="16">
        <location>
            <begin position="127"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="15">
        <location>
            <begin position="266"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00065822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5495600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="754" mass="82681" checksum="897187B1A211E117" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN19</accession>
    <name>A0A9W9XN19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_001120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795017.1">
        <property type="nucleotide sequence ID" value="XM_056930724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN19"/>
    <dbReference type="GeneID" id="81620973"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12160">
        <property type="entry name" value="2-Hacid_dh_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="103"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5496004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="311" mass="33845" checksum="2A95EABD6DEECBAC" modified="2023-11-08" version="1">MKLLYPTSVKLDVPSLQGFAVSLHPYDVKSTIPEEHVDAEILITWSNSAENLKDAAQRLKNVKWIQSLAAGPNDVLSAGFDSSKTLVTTGVGLHDYPVAEHTMGLLLNAARHFYEMRDYQLQSKWPGHLGGSFPRSDFTTLRGARVLIWGYGSIAKTLTPCLNALGAQVKGIARSQGVRNGVEVYAEDKLPELLPETDALVMILPGSDSTVNVLNAERLELLPKHAWVVNVGRGVSIDEDALADALEKGEIAGAALDVFKQEPLPESSRLWKTPNLIISPHAAGGRPQGCEALITENLRRFLAGQELRNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN64</accession>
    <name>A0A9W9XN64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_001180</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795077.1">
        <property type="nucleotide sequence ID" value="XM_056930784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN64"/>
    <dbReference type="GeneID" id="81621033"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07627">
        <property type="entry name" value="BAR_Vps5p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06861">
        <property type="entry name" value="PX_Vps5p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000013">
        <property type="entry name" value="Putative Sorting nexin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000022">
        <property type="entry name" value="Sorting nexin 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035803">
        <property type="entry name" value="BAR_Vps5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037868">
        <property type="entry name" value="PX_Vps5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="168"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="544"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5496064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="581" mass="63937" checksum="CC6E289EC423C57E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ85</accession>
    <name>A0A9X0BJ85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785885.1">
        <property type="nucleotide sequence ID" value="XM_056938508.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81628758"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5469295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="72" mass="9607" checksum="B2BEA123441E46E6" modified="2023-11-08" version="1">MRSFLGTVFRRKYYYYYYYYYYYYYYYYYYYYYYCTTNSRAKHHVQGHLIFWSVTLFREITYSTTFWPRVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJB1</accession>
    <name>A0A9X0BJB1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_009003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785975.1">
        <property type="nucleotide sequence ID" value="XM_056938598.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81628848"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
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    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
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        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42972:SF8">
        <property type="entry name" value="POLYHYDROXYBUTYRATE DEPOLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42972">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040864780" description="CBM1 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="4">
        <location>
            <begin position="362"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5469385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="400" mass="41376" checksum="DB573CD7A8B00CD3" modified="2023-11-08" version="1">MPYRSALVGLASFAGATTAASTLGAYNVDPSSVSVSGLSSGGFFSAQLGVAYSNVFQTGFGVFAGGPFDCARNQAYTSCMYNGNPSITTPIANMKSWSGNQIAPTSNLKNRKIYLWTGSADTTVGPNVMNALNSQLSNFDTSADVSYVTTSGAVHTFPTDFSGSGDNSCSMSSSPYISNCNYDGAGAVLQWMYGFLNARNTGTLSGSIVSFAQTGAYGAAGMDSTGYLYVPASCQGGSTVCKLHVALHGCLQSYSNIQMEFVQNTGYNKWADTNNIIILYPQAIPDNTIHSTWEGSLSNPNGCWDWVGWYGSNADQIGGVQMVAIVNQVAQIISGSTGGGSTTLTTSTKPSTTTTSAAGSGTGAPLYGQCGGFGWTGPTTCAQGVCTAYSAFYAQCLLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJI6</accession>
    <name>A0A9X0BJI6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_009127</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786099.1">
        <property type="nucleotide sequence ID" value="XM_056938722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJI6"/>
    <dbReference type="GeneID" id="81628972"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF100">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040785826" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="126"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="9">
        <location>
            <begin position="498"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5469509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="70054" checksum="DCA94C096EC212D4" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJY4</accession>
    <name>A0A9X0BJY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_009320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786292.1">
        <property type="nucleotide sequence ID" value="XM_056938915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJY4"/>
    <dbReference type="GeneID" id="81629165"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039113">
        <property type="entry name" value="ATG29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040666">
        <property type="entry name" value="Atg29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039362">
        <property type="entry name" value="ATG29_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18388">
        <property type="entry name" value="ATG29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Atg29 N-terminal" evidence="8">
        <location>
            <begin position="11"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="170"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="193"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="294"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5469702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="445" mass="48807" checksum="A6B40262337F16AE" modified="2023-11-08" version="1" fragment="single">TAKMESSNANFTVFIRLPFPRGDFIDPPPVEWDATKDQALWDVLSRPSKGKDIDCKNLLALPNLNSSIIILQTNRHTGKALAEHFDVTLQFLLQQAAWLYDRQLSQVRAQMRKVPPVQPSTPSPVPDSVSGSAALTVQAQRQLPGVGEGLPPRRYGLLYAHSDLTILDPNLPTASEDRRASSTSTATLNQFRHSRDSSRHEPVQGTERRWENFVRRPSGARREPPSSSSHVRSPPLAEQEPSSSSTDPDSESDVESSRGLPRFKKFGKFSMQRAGLSDAEDEDEDDVPAFLPMARDKTSSMRGQSDEKLSTTIRDNEKPLPYRPSKGERTDRKPKPSTESFNSSISSGTPASLSTSDRQGLGQLPSALSPHRVGEPPRQSPRKSAASGREASDGTPSMGSSFSDLDDASVTQSALEEALMSNMQHGGMASRMSTISQALRSRYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BLS6</accession>
    <name>A0A9X0BLS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_008493</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786470.1">
        <property type="nucleotide sequence ID" value="XM_056938088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BLS6"/>
    <dbReference type="GeneID" id="81628338"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022099">
        <property type="entry name" value="DUF3638"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF34">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
        <property type="entry name" value="DUF3638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUF3638" evidence="7">
        <location>
            <begin position="38"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5471924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="243" mass="27694" checksum="2B0DF0628BC40B33" modified="2023-11-08" version="1">MKLQDRYPELSSLQRAERLCRLVHSPEDLLKEIRNPGHTNWDPFEEPENLLLEIESGILIRPNQENVTRTMTWSTRGQNIVLELNMGDGKSSVVVPLVAVAHANGRCIARILTLKPQSRQMYQMLVGKLGGLLDRRVYQLPFSRSLSLGEAEVDEIQRMCYECMSIGGVLLVQPEHILSSKLMCLECFIMGKLAVGRSLLHTLNFFREYACDIIDESDETFNAKFELIYSMGAQRPVELSPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BLZ0</accession>
    <name>A0A9X0BLZ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786665.1">
        <property type="nucleotide sequence ID" value="XM_056938283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BLZ0"/>
    <dbReference type="GeneID" id="81628533"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5472119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="89" mass="9445" checksum="8FD9779EB07FBA6E" modified="2023-11-08" version="1">MPLTLRFDDTKSGSVNVDDGASASKGTDIGRLSDIDFEADVSMDVIRGGEILVTITDHVGNVVQDAFAIPDTNCSFEDVPRPCDGLEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BM08</accession>
    <name>A0A9X0BM08_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_008775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
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            <dbReference type="EMBL" id="KAJ5475061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="965" mass="106969" checksum="E0DF81E866397D91" modified="2023-11-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNC7</accession>
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        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Penicillium diatomitis</name>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAJ5475409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43402" checksum="1220718849EEF3C8" modified="2023-11-08" version="1">MVKKKTKQRRAQEEPLNPMSVQVSPKVDYVQPLSSPYEGPVVTATIGNKQYCILGYCLRKCPQFEQQSVLSSYITLPYIHEDVGHTFVHFLYSGCYETIDSPVDDGISSAMREYRRSVLIYQASRTYQLPSLEALARDYIERFGEEMSISDILRTTSEVFSNLPEDETWLPKYIERNLRHSLRSSKSKFDVDELYKAFGQDHYFDNTVTRMMLEILLRPQEFTSQDGKSDCEQIRIHGNTEVKASIGNPLDGIAGGRQLTEAWTNGMPAIGESFVPFPSAADEPGAADEPGAAFNEPGAAFNEPGAAFNEPGAADEPGAAFNEPGAAFDEPGAAEDSTDRLHPTKVCLEDVALYQHWKSMSSKRRAKRTRALVAKGLPIPGKDGLVSILVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNQ5</accession>
    <name>A0A9X0BNQ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_007254</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787654.1">
        <property type="nucleotide sequence ID" value="XM_056936855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNQ5"/>
    <dbReference type="GeneID" id="81627104"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF165">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="6">
        <location>
            <begin position="37"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="5">
        <location>
            <begin position="253"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="7">
        <location>
            <begin position="616"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5477110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="846" mass="94517" checksum="FA184A680AB6C788" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNS0</accession>
    <name>A0A9X0BNS0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_007965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787431.1">
        <property type="nucleotide sequence ID" value="XM_056937566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNS0"/>
    <dbReference type="GeneID" id="81627815"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.480:FF:000004">
        <property type="entry name" value="Indoleamine 2,3-dioxygenase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00876">
        <property type="entry name" value="IDO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5475678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="483" mass="53426" checksum="88051338F88C3E7A" modified="2023-11-08" version="1">MLPPVPSLAAYGLSPEHGFLPPELPLETLPDLYYAKWEAIAANLQPLLLSKRIRPVIDRLPLLSTEHLQTEAEWRRAYVILVFLLHSYVWGGERPAERIPPQLTVPLYQVCERLEVPPVATYAGVCLWNYKPIFPDEPADSLDNLACLQTFTGSLDEQWFYLVSVAIEAQGAPALPLMLQAIAAARAGNASQVTACLQRLAEIIDEITLLLQRLYENCDPHVFYHRIRPYLAGSKNMSEAGLPHGLLYDDGTNPPEYRQYGGGSNAQSSLIQFFDIVLGVEHRPTGVGPHDQKKSSSPSTSGTARPRHGFIHEMREYMPGSHRRFLQDVEAVANIRAYVDARRTDPALRIAYDACLSMLRNMRDKHIQIVSRYIIVQSRGNQQAPPSSMRPAAMNLATVVPTDGKKLRGTGGTALIPFLKQARDETGEPAIDAWARRLLSNTPGAMDSASLSKVGEQPDGHLQVVGLCGTWTADDSEGGICHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSG8</accession>
    <name>A0A9X0BSG8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_006636</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788172.1">
        <property type="nucleotide sequence ID" value="XM_056936237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSG8"/>
    <dbReference type="GeneID" id="81626486"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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        <property type="entry name" value="Kelch motif"/>
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        <location>
            <begin position="852"/>
            <end position="893"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="708"/>
            <end position="731"/>
        </location>
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        <location>
            <begin position="784"/>
            <end position="814"/>
        </location>
    </feature>
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        <location>
            <begin position="853"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="864"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5480742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="893" mass="95498" checksum="79EEF4F00D4D1517" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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        </source>
    </reference>
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            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5480831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="29683" checksum="C4A111CFF8B91FB4" modified="2023-11-08" version="1">MSTSAECNAVLKDTISPSLLGQVRKVWFEHIKTEDGLIFPSQDDFKRWFVRDESFDQICAEQFKTALDQILESKASAQDMLEVIDTSSPLDWLSVILLLDQVPRNCYRGDASKMVFERFDPLAEAVALRDIDAGIPAMSSVVRYRLAYRMWFQLPLMHSEKLSVHEKAVAQYENIAKDVDDLLTQNPSTLGDDEKECHKVLSKNTEAVHGSLSHQLEFEKRHKVIIQRFGRYPHRNQALGRSSTAEEVEYLENGGETFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUN5</accession>
    <name>A0A9X0BUN5_9EURO</name>
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            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="17" type="ORF">N7539_005075</name>
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    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
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    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
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        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977">
        <property type="entry name" value="TARGET OF ERK KINASE MPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
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    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040918595" description="RING-type E3 ubiquitin transferase" evidence="15">
        <location>
            <begin position="23"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="365"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
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            <end position="362"/>
        </location>
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            <begin position="414"/>
            <end position="456"/>
        </location>
    </feature>
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        <location>
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            <end position="546"/>
        </location>
    </feature>
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        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
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        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5485087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="546" mass="58456" checksum="096B26A1682102C6" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUW0</accession>
    <name>A0A9X0BUW0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789809.1">
        <property type="nucleotide sequence ID" value="XM_056934615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUW0"/>
    <dbReference type="GeneID" id="81624864"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040906457" evidence="2">
        <location>
            <begin position="21"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5485025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="411" mass="40690" checksum="0FCF0147272D6452" modified="2023-11-08" version="1">MLFNKLSLVLVAGLAASGQAERHARRVHRVPRSVIPTIPAPLPTTTTTLSSASSASETESATLTSVESSNVAVTSVEAPSSSVVIPTEASTSIVVPVQSSSSAVAPTVASSSIVVPVVSSGFAATPAQSSGSVVLSAAPTNHIATPSAEASSSAISSSVVLSHHPAHGSSSVVVIPTGPASVSTSAVPTVVTVTYTVGSEVTTSVYTTTVSRTMTDYHTVTAAPETNTQVPDATNQISDVNLSSQAPDAKGHNQSGSETKTTLHSTTTKTVTLIEHPTSTVTAGRATATGNSGADANGSGSGNGSGNASQCSPQTVTVTAAAAGTVTVTATQTVTVSAESAATSVPAQNHHQQSSDNANSQTEQSTAAQTSTIVVVPTPSSSRVPSSRATPSGFATSSMMVRPPSPAALPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BV08</accession>
    <name>A0A9X0BV08_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_005480</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790276.1">
        <property type="nucleotide sequence ID" value="XM_056935082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BV08"/>
    <dbReference type="GeneID" id="81625331"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000399">
        <property type="entry name" value="Nuclear cap-binding protein subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="48"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="126"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5485492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="176" mass="20536" checksum="2A42572928046309" modified="2023-11-08" version="1">MSTLAINTVDRLDRPSAYYVGKNKRRSRYNDDDEPEREDPMAKLKDATTLYVGNLSFYTTEEQIHELFSKCGEIKRLVMGLDRFNKTPCGFCFVEYYTHQDALDCLKYIGGTKLDERIIRTDLDPGFEEGRQYGRGKSGGQVRDEYREEYDPGRGGYGRAYDEQRQREEEQYGEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BVG7</accession>
    <name>A0A9X0BVG7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Inactive metallocarboxypeptidase ECM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Inactive metallocarboxypeptidase ecm14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">N7539_005643</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790439.1">
        <property type="nucleotide sequence ID" value="XM_056935245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BVG7"/>
    <dbReference type="GeneID" id="81625494"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000060">
        <property type="entry name" value="Putative metallocarboxypeptidase ecm14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF147">
        <property type="entry name" value="INACTIVE METALLOCARBOXYPEPTIDASE ECM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040731425" description="Inactive metallocarboxypeptidase ECM14" evidence="18">
        <location>
            <begin position="20"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="19">
        <location>
            <begin position="195"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00026213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ5485655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="539" mass="60565" checksum="A3843EF49B164D66" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXS7</accession>
    <name>A0A9X0BXS7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein negative regulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790505.1">
        <property type="nucleotide sequence ID" value="XM_056932964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXS7"/>
    <dbReference type="GeneID" id="81623213"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="44284" checksum="0E84F07832F30136" modified="2023-11-08" version="1">MSEPDSGPKCVASTETHSLEPRKDRQDAHYKSVQWSPDGTTLLTCLSDHRSQSYILPPDLLEGTSPHRLSPYSTLPSAEPTYAATFYPFYNLQDPSTTLFLSSVRDHPIRLASTLAPTSVATYSLVNPTTEAFITPHSMIFPASMGGTHFLAGSDSMICLFDVSRPGTSGPVSWMPTIPSKRKQIVGGGIGMKGIVSALASNPSGDGILAAGTFTRHVGLYSANGAGESLGTFNVARTDASRVIGGRGITQLCWSPCGRYLYIAERKSDGILVYDIRVTGQLLGYLRGRKALTNQRMDIDVVVTGPDGGHEVWAGGTDGMMRVWRNPVYSAGGQMPDGEVHVHDDAVPSATFHPFGDVVATCSGQRHRLSAELDEEDISVGDVRRVDNSVKVWSMPMSGSPRDAHEVDVSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY78</accession>
    <name>A0A9X0BY78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_004129</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791272.1">
        <property type="nucleotide sequence ID" value="XM_056933731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BY78"/>
    <dbReference type="GeneID" id="81623980"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000552">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="2"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5489239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="279" mass="31171" checksum="425C5A3E3318BF59" modified="2023-11-08" version="1">MSKFGVLVMGPAGAGKTTFSNALIQHLQSTRRSCFYVNLDPAAENFAYQPDLDIRELITLEDVMEELGLGPNGGLIYCFEFLLQNLEFLNEALDPLSEEYLIIFDMPGQIELYTHISPSSRPLNINLCAAYLLESTFVVDKAKFFAGTLSAMSAMLMLEIPHVNILSKMDQVKDMVTRRELRRFANVDVQLLQKDEEDAAAVANPMAKDALMSGGSFNQLNRAVAQLIDDFSMVSFLQLDASDEDSVAGILSHIDDAIQYHEAQEPREPKDEQEVNYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYV5</accession>
    <name>A0A9X0BYV5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Crh-like protein</fullName>
            <ecNumber evidence="15">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">N7539_002618</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="15"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792180.1">
        <property type="nucleotide sequence ID" value="XM_056932221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYV5"/>
    <dbReference type="GeneID" id="81622470"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF27">
        <property type="entry name" value="GLYCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 21" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040976598" description="Crh-like protein" evidence="19">
        <location>
            <begin position="22"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="20">
        <location>
            <begin position="17"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ5491051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="379" mass="39302" checksum="46E67D4E1631F97D" modified="2023-11-08" version="1">MPSFFKYAAMALAVAAPFASAQTYTDCNPLKKTCPADAGSTESKMSFDFTKPSGLNKWKTTAGKVNAGPNGAAFTVAQQGDAPTIETDFYIFYGEVSVTMQAAPGQGIVSSIVFESDDLDEIDWEALGGNTAQIETNYFGKGDTSTYNRDTWPAVANPQTTFHTYTVNWQKDKTVWSIDGTPVRTLQYSDASGGSRYPQTPMRVRIGVWAGGDPRNGKGTIEWAGGATDYSKAPFSMYVKSVSITNTNPATSYTYTDNSGSSGSIKMNGAGTLNETSVSSGVVSATTSATDSKSTATGTGTHTTMATTVHTTATSSIEAISTGSSSSIDASSSTSKSGSPSAASSSAQPTASYNAAPSVVASYLGPVSLLGLVTALLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ10</accession>
    <name>A0A9X0BZ10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA mismatch repair protein MSH5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MutS protein homolog 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_002783</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792345.1">
        <property type="nucleotide sequence ID" value="XM_056932386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ10"/>
    <dbReference type="GeneID" id="81622635"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03281">
        <property type="entry name" value="ABC_MSH5_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001067">
        <property type="entry name" value="DNA mismatch repair protein MSH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="13">
        <location>
            <begin position="696"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5491216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="872" mass="96156" checksum="FDF1D4795C60EEC0" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZN1</accession>
    <name>A0A9X0BZN1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792827.1">
        <property type="nucleotide sequence ID" value="XM_056932868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZN1"/>
    <dbReference type="GeneID" id="81623117"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5491699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="64" mass="7215" checksum="4D6A50936B929F6A" modified="2023-11-08" version="1">MPESTDCLQPPLTPAQRSIVKSYGGWSMFLRSFGLKPWNDEDAEEGLRILKALLEDDDDDGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0G0</accession>
    <name>A0A9X0C0G0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793319.1">
        <property type="nucleotide sequence ID" value="XM_056931288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0G0"/>
    <dbReference type="GeneID" id="81621537"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="158" mass="17093" checksum="C4A507F8755D2D97" modified="2023-11-08" version="1">MTTRKRKAEAEEELQALPSDESEEEEEYEDSEPDRSDVSDEGEEGEEGEEGESEDEEEEEEAGEDEGPPAQKKQKTDKTTNGKQAPEVVDDDEDDGAEEGAEEQGDEDEEPAEEEPAEEDVEDENETAKSSGPAAAAKKAKGGTVPKEADLSEVDAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C357</accession>
    <name>A0A9X0C357_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Vacuolar fusion protein MON1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_000966</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">In complex with CCZ1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The MON1-CCZ1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endosome</location>
            <location evidence="5">Multivesicular body membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 5">Prevacuolar compartment membrane</location>
            <topology evidence="1 5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Vacuole membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MON1/SAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794863.1">
        <property type="nucleotide sequence ID" value="XM_056930570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C357"/>
    <dbReference type="GeneID" id="81620819"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 5" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="7">
        <location>
            <begin position="234"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="8">
        <location>
            <begin position="395"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="9">
        <location>
            <begin position="560"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5495850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="670" mass="73390" checksum="4DAD7DF306C7CCBA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WK83</accession>
    <name>A0A9W9WK83_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Peptidyl-prolyl isomerase CWC27</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Peptidyl-prolyl isomerase cwc27</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Rotamase CWC27</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">N7539_009535</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 23">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cyclophilin-type PPIase family. CWC27 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785625.1">
        <property type="nucleotide sequence ID" value="XM_056939130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WK83"/>
    <dbReference type="GeneID" id="81629380"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000034">
        <property type="entry name" value="Peptidyl-prolyl isomerase CWC27 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 21" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="20">
        <location>
            <begin position="18"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="198"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="414"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="469"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00067721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ5466579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="563" mass="62308" checksum="50622AA26E46D9A7" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKJ9</accession>
    <name>A0A9W9WKJ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase BUR1</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Serine/threonine-protein kinase bur1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">N7539_009487</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785804.1">
        <property type="nucleotide sequence ID" value="XM_056939082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKJ9"/>
    <dbReference type="GeneID" id="81629332"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07866">
        <property type="entry name" value="STKc_BUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000562">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000514">
        <property type="entry name" value="Serine/threonine-protein kinase BUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="25"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="356"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="480"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00073250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ5466758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="554" mass="61472" checksum="B3AE7FED9D616984" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL29</accession>
    <name>A0A9W9WL29_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase substrate phosphoprotein PP28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_009092</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786064.1">
        <property type="nucleotide sequence ID" value="XM_056938687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL29"/>
    <dbReference type="GeneID" id="81628937"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019380">
        <property type="entry name" value="Casein_kinase_sb_PP28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039876">
        <property type="entry name" value="HAP28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22055">
        <property type="entry name" value="28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10252">
        <property type="entry name" value="PP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Casein kinase substrate phosphoprotein PP28" evidence="3">
        <location>
            <begin position="168"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5469474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="262" mass="28567" checksum="A0C3461206EE22E6" modified="2023-11-08" version="1">MAPRGRGGKFSKPTRGGGKKFSRDLQPTDKDGNPVSLWREKDDGIPSSSEEESSSEEDSEEESSSDDNDNDNTPTTIAGVPGSTTQTDSANDNLSREARRAAAKAKKQAAIARRGKAPAQPGDLPPLTATTPTGPPQKTSTICLRTLITARNLDLRLPSPGAGAKKVVKDPSQLSRREREAIEAQQARERYLKLHAEGKTDEAKADLARLAVIREQREAERLRKLAEKEEKDEQLRAKAALIKEREDKLRQAALGKAKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL57</accession>
    <name>A0A9W9WL57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription initiation factor IIF subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_009040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786012.1">
        <property type="nucleotide sequence ID" value="XM_056938635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL57"/>
    <dbReference type="GeneID" id="81628885"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="158"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="377"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5469422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="751" mass="83189" checksum="F221DFAC453BB48C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLL6</accession>
    <name>A0A9W9WLL6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786331.1">
        <property type="nucleotide sequence ID" value="XM_056938954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLL6"/>
    <dbReference type="GeneID" id="81629204"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="98"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5469741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="406" mass="45540" checksum="86FC86EA5637F6D1" modified="2023-11-08" version="1">MGEAEYDPAARKAEQDEITKLIDKINIPALISRASALRGGLTCSILQDLRYDRSTRSSVMGGMNYHIEISFDDGISWLARVRRSNATSPPAELRDYILRSEVSTLHFLGETQVPVPKVFDFNFCEPNPIGVGYILMEKLPGSSLRWSLATPEQRKKVASQLADIYIELKAHPFAMTGSMHHPGSYDLGPFARESLTDFHDSQMKALGPFFSIELYFSAHIRLILDLIVRQESYVDRAVDAFLIHRFLLDKVPEACSQRLLDDGKFYLKHADEKGDQILVDEEFNITGIIDWEWAYTDSKSGAFNSPIVLLPVADFYAGKTSIGEDETFLQSALKQKGIRISERLSGMAGSSTDFDFAAVTTSQIGRDSLGSLPDFWEPWASLVISIGRLGRQKHWNTTKMIINSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQT6</accession>
    <name>A0A9W9WQT6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786537.1">
        <property type="nucleotide sequence ID" value="XM_056938155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQT6"/>
    <dbReference type="GeneID" id="81628405"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5471991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="119" mass="13383" checksum="3DFA3F309D9AEE3F" modified="2023-11-08" version="1">MMAATEYEDGGIRVDDIANNNAKLEEKATQETGEDVYIDKEDTKVRELLSSESVRAVLLRKQSQPGCARVEPDEKEANEKPSKYTLTEKLDGTVLVVAKQKESIILLGNITVRCFRRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTL9</accession>
    <name>A0A9W9WTL9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787065.1">
        <property type="nucleotide sequence ID" value="XM_056937973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTL9"/>
    <dbReference type="GeneID" id="81628223"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040723523" evidence="1">
        <location>
            <begin position="26"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="173" mass="16976" checksum="F110E434D98AFB7F" modified="2023-11-08" version="1">MRLTNTVSFLALTLTSPLAVLPVNATSTTTAPTPDKSCGPCQHGYVCKNGSCILDTEHLTNPLQIFSTLSSVNPGGPIQTTGMTVITGTSSVMSMSMSTSTSMSASATATASMTSAVGSTMSGASASASGSASASASASASTTPASAGGRVLSVEWSVWSVLGLVAAGAPFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTM3</accession>
    <name>A0A9W9WTM3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CAZyme family AA7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_008350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787042.1">
        <property type="nucleotide sequence ID" value="XM_056937950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTM3"/>
    <dbReference type="GeneID" id="81628200"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040863225" evidence="3">
        <location>
            <begin position="21"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="112"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5475284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="578" mass="63484" checksum="3FDA46249FF99EB3" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTV3</accession>
    <name>A0A9W9WTV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinetochore protein Sos7 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_007714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787180.1">
        <property type="nucleotide sequence ID" value="XM_056937315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTV3"/>
    <dbReference type="GeneID" id="81627564"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037475">
        <property type="entry name" value="Sos7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048781">
        <property type="entry name" value="Sos7_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329:SF1">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20882">
        <property type="entry name" value="Sos7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Sos7 coiled-coil" evidence="3">
        <location>
            <begin position="70"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="105"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="199"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5475427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="283" mass="31933" checksum="65FDD09F036A0060" modified="2023-11-08" version="1">MADPQLLLQQLEREQGDLKKQLTIIRISEPISDVSNTDFSPSKRGSDVSISNLNDPTPASLESDLTHYKELFSKLRFSYLEQVTKEKFLRAIVGDPPLVVGHNENVELESQLAEVKAELKSRKEEARLMIEEMETMSRELARRYKNVETQMAQLSSLPESIENLESTIAGLRAKQVAGMTSSDPRSSQNLPLPATLALLSEREAELAALNRQILAVQNSLPRKTREAEAIERECSVLERRKTEAINQAREARRKKEQGESDGLEEMGRWYKGAEQIMNQVLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTV9</accession>
    <name>A0A9W9WTV9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAFII55 protein conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_008229</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786921.1">
        <property type="nucleotide sequence ID" value="XM_056937829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTV9"/>
    <dbReference type="GeneID" id="81628079"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="7">
        <location>
            <begin position="126"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="354"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5475163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="463" mass="51818" checksum="E763BE56C3255799" modified="2023-11-08" version="1">MSESKGPTLKLKFGKKPATPQPPPEPAPAEPSSQPKLTLKIGRKNQPPPDGSEEKAKKKKAPSKKRPADNATVPETAAAPPGPKRLKLNTSKLKSIRIKNKGHVPNRPVGVGYDSEASDTEIDPAIEEQFILRMLPGEDCEYLRKAIEERKFDKSEFSFKPLTREGRRAILKIRNKQYACCLVDLPCIIEGMKSWDRRGWYKSADICQMLLVLGTVSNDQEALEYPLPPEVEASDPKTLQYPHGLAPPLRWVRKRRFRDRVSSRTIEQVEKSVEDLIAQDEQSLFPPRFDLVDSASLNRAEGFVQEDYEEDYDEEQDAEGEIDEMLDDFEDDLAAEMEAALAAGDDDAAAAVTEAVQAATASTPAAPTDRGGDSSGDENDVSDEDDDIPEDDLDEEQLEQQRQLQQHREEIAELEALIQTETANWQTVQNHILRNKMGRRIQELKKDLELKKVSVGLPGENDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU72</accession>
    <name>A0A9W9WU72_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="42"/>
        </location>
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            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="524" mass="57689" checksum="147DCEB25B06D430" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU98</accession>
    <name>A0A9W9WU98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786980.1">
        <property type="nucleotide sequence ID" value="XM_056937888.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81628138"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="363" mass="36529" checksum="3681A16DC525C656" modified="2023-11-08" version="1">MLLVDGALAVRSRTVTPSFPASPSSTPVHLHHHDPHHRHHWTYKPVPWHKHTRSCKPIPQSTPVVSVSVTMHSSTPVPHGSTAIVTTPTQSSGAVSQVTSLAPVTSQPAQSSDSVPQTTSTVFTTRTSTITACPTTVHNCPASQKTTYITTETLVVTTTVCPVTAGSVPTGQATKPDNGPSVITSTVLSTRISTATAFPGTYVTTETLVVGTSVYTVYPVPTTGSSSGSSGSGSSASGSPGSDSSGSSGSGPSHGSATNSAQTGTNHGVSPVSATSVAGQPCHGSSCMGFTGSSTPVPSSIMTTLRGQSATSIPYVNTATTTATSSSTGSTGNAQFNAASPSMGPSLFQLMSLVMAAFVALVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUD0</accession>
    <name>A0A9W9WUD0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_008333</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787025.1">
        <property type="nucleotide sequence ID" value="XM_056937933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUD0"/>
    <dbReference type="GeneID" id="81628183"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5475267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="267" mass="29948" checksum="DB4BD855BE74282E" modified="2023-11-08" version="1">MAAQGVEQTILRDPALFYWILFPISVVMILTGILRHYATVLMNTPPKPASTLAESRERHALLRGVNLRNHGCAVLDREAFEARRNYLVNGFRTGAFLKDPNNRGQPPANPMTDPAGMEAMMGMLKGNMMMMIPQTLIMSWINAFFSGFVILKLPFPLTIRFKSMLQSGVMTRDLDVQWVSSLSWYFLNLMGLQSIFGFILGSDNAANQMAQQMGMANPAAMMNPMQPGQDPDKLFLAEAENLEVMEHFSILNGVEERVLRNFAPEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVT3</accession>
    <name>A0A9W9WVT3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED18</name>
        <name evidence="9" type="ORF">N7539_007340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVT3"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019095">
        <property type="entry name" value="Mediator_Med18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09637">
        <property type="entry name" value="Med18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5477196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="284" mass="31476" checksum="50FA51019B0D0249" modified="2023-11-08" version="1">MHELLLFASVPVHQHHELLQQLAGLTAMQPRHALERRLVYKAFRKPGLNTGRVGGSQDLQQANAADLQRVNKMLNGGMFYTQVVGPVSEKDFAAAPVKVTASELDSDTQMAGMELSNPSASVQADTAATYDFDRQPWKLDFRDIPEAATRSAVTTRVMASAALPRGNIEPSMNAWGYGFVTEYVVEGDIFIHNDIVIFLHRVLHYPSDEKEPREPRRSLPSLKKMAPLEKTGSYVLQASIAVQDGSNQETMKTASQHLLGLREQLKSAVRLEPADRLSLDTRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1S8</accession>
    <name>A0A9W9X1S8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="10">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_006687</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="10"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788223.1">
        <property type="nucleotide sequence ID" value="XM_056936288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1S8"/>
    <dbReference type="GeneID" id="81626537"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000046">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="34"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5480793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="381" mass="43568" checksum="DCD02841A08664F7" modified="2023-11-08" version="1">MIMPLDHSPSTSRGLAQFQKREIMGVLFETTERYQQLQPVGMGVTGLVCSAGDQIGHQTVAVKKLPEPFKTANIAKHMYREIKLLKHLQHENIIHLKDIFISPSEEIYLITDLMATDLHTLLNTKRMDNQFTEYFLYQIMRGLKYVHSAGVVHRDLKPGNILVNENCDLKICDFGLARMQEKDMTGYVATRYYRAPEIMLTWRQYDEKVDIWSVGCILAEMLTGKPLFPGKNHVHQFCIITEVLGSPPEHVVKNISSPNTLKFIESLPERPRKSFSSIIPDGNKKATDLLDKLLRYDPQERMSAVDALQSPYLATYHDPEDEPVAPLSFDWSVLEADLPTDTWKEIMYSEVLAYHEHSPGMKERNDGSFHLSEPFDGMDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X243</accession>
    <name>A0A9W9X243_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788435.1">
        <property type="nucleotide sequence ID" value="XM_056936500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X243"/>
    <dbReference type="GeneID" id="81626749"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040757335" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5481005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="15546" checksum="48F9C924526BAE23" modified="2023-11-08" version="1">MHFTKSLIVLAAALMPSAFAALQAAEPTASVTSTITLVPSGYTSTSSTSSTPISTSTSISTTSFSSSTSTSISSSTSTSSVPAWTPKPTGTARGSSSSLVRVPTSTPLIKSTSTYVETNTAGATSAASATPTHNSASMRQVSGGLAAGVVAVAGMLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X250</accession>
    <name>A0A9W9X250_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788489.1">
        <property type="nucleotide sequence ID" value="XM_056936554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X250"/>
    <dbReference type="GeneID" id="81626803"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5481059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="219" mass="24189" checksum="D49C9BD3FD507DA0" modified="2023-11-08" version="1">MPAYEPKAVAQYRITSVESTRESRRESRRKSSRAYDISESSGHAEYHVNLEPIWDRFHRKDLVFYEGPESKPGPIVACTKFRRAVKHVELGFGDLAEPSDIEWSEMRCEKLVVHYVFTVPVGDDRKPHTFVWKRTRSQGIGSRGLKLVDEADRLIAVYSAGGCMSSNTGQIDIYEDFGGHFQLVVLVSALAVRQRLLRSRDAAAAGAASGGAAAAGAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2M5</accession>
    <name>A0A9W9X2M5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mannose-1-phosphate guanyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_006160</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788686.1">
        <property type="nucleotide sequence ID" value="XM_056935762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2M5"/>
    <dbReference type="GeneID" id="81626011"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071554">
        <property type="term" value="P:cell wall organization or biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05824">
        <property type="entry name" value="LbH_M1P_guanylylT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06425">
        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000017">
        <property type="entry name" value="Mannose-1-phosphate guanyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000013">
        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045233">
        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="16">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="17">
        <location>
            <begin position="256"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5482714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="360" mass="39668" checksum="5A26963CE2B2E503" modified="2023-11-08" version="1">MKALILVGGFGTRLRPLTLTLPKPLVEFGNRPMILHQVESLAAAGVTDIVLAVNYRPDVMVSALKKYEEQYGVNIEFSVESEPLGTAGPLKLAEKILGKDDTPFFVLNSDVICDYPFKELAEFHRSHGEEGTIVVTKVDEPSKYGVVVHKPNHPSRIDRFVEKPVEFVGNRINAGIYIMNPSVLKRIELRPTSIEQETFPAICKDGQLHSFDLEGFWMDVGQPKDFLTGTCLYLSSLAKRNSKKLAANSEPFVYGGNVMVDPSAKIGNNCRIGPNVVIGPNVVIGDGVRLQRCVVMENSKIKDHAWIKSTIVGWNSSVGRWARLENVTVLGDDVTIADEVYVNGGSILPHKSIKQNIDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2N8</accession>
    <name>A0A9W9X2N8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788387.1">
        <property type="nucleotide sequence ID" value="XM_056936452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2N8"/>
    <dbReference type="GeneID" id="81626701"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5480957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="481" mass="53279" checksum="8884ABE3741A076F" modified="2023-11-08" version="1">MSNGSSVTDHIPLSNVLSALGTLIGYIGTEVATADPIDRLLWPRRAFQNFSMQNAWKVALFMPLGGPLHKTALETMDTFVKHGLFQGELCGHMLGTAFFPDTYMTYQLYQDGLMKREASVRNGLWVRVMDQISSHALKPSVNMQEAEIKNAEASYTRTITRRQVVTVSYLQLSVIEHQHISRQGLKDLVVESDVGPVSWKIVLAIVTTELTAIGVALAVVLIWRSAFMIMWLIPLMLKLLCAMFTLSREDIMIPRPMANSCASAPPSKQGDGLENPENISVTIPISRVLVKNKQGLQVISGPENLVMQFFRHYGHPRRCRWKEIIEIATIAALGLNFPCGLVCSLIWMPVSLQCVWTFYALYVTCVMYIARYSHGAWWATAEELLADNFVRAEEMPGEPGIILKTGDGNGIMAKFTRTTHDSYACARDHAMHLVGASSKSTPTKPAAASERKISGTTLSENLRPEELISGTPLSEKTSCEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2R9</accession>
    <name>A0A9W9X2R9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_006615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788151.1">
        <property type="nucleotide sequence ID" value="XM_056936216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2R9"/>
    <dbReference type="GeneID" id="81626465"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF15">
        <property type="entry name" value="CHOLINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5480721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="538" mass="59180" checksum="CD5CD9EE6F210579" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2W7</accession>
    <name>A0A9W9X2W7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788851.1">
        <property type="nucleotide sequence ID" value="XM_056935927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2W7"/>
    <dbReference type="GeneID" id="81626176"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5482879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="68" mass="7840" checksum="0EFA708145D7A252" modified="2023-11-08" version="1">MVNHARSPQRVGKHRPCRGAGGRDPSSNAYMVEWITQAKQVKQVKQVKQVKQVKQERTIVMQPASWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X313</accession>
    <name>A0A9W9X313_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspergillopepsin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788597.1">
        <property type="nucleotide sequence ID" value="XM_056936662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X313"/>
    <dbReference type="GeneID" id="81626911"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040842989" evidence="2">
        <location>
            <begin position="19"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5481167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="277" mass="29065" checksum="76A02C9191747DFB" modified="2023-11-08" version="1">MKLSLALTTATLVAGALAAPRSGLARRLEARGILGRRSVPPSKMETLVGENGVLVKSDDGSAEVQYSKNWAGVVREQPPAASATYTQVSATFTVPLPTATDYSGDIQAASAWVGIDGDTYTNAILQTGVDAYVNSNGERAYDAWYEWYPNAAENFAIDLTAGDVIVATVKSTSPSKGVAIIENKSTGQSVTKSMSAPSSSTTLGGQNAEWIVEDFNSGSTMVPFANFGQIDFTGARAKTSQGDLGVQNATVLEIEQNGAVLAKVDVKSDSEFTVTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3R8</accession>
    <name>A0A9W9X3R8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789052.1">
        <property type="nucleotide sequence ID" value="XM_056936128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X3R8"/>
    <dbReference type="GeneID" id="81626377"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF11">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5483080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35544" checksum="1989C91C291C6BDA" modified="2023-11-08" version="1">MTTAKPPFESLPLRKDGPAGNAWGLFGEHDELGMLNLLTPATTRAAAQEIKEGVRVSTDWSLDSMAVPCFGRVPFEHTLKNKAPRPVNDDILTFNTQSSSQWDGFRHFGYKDGSVFFNGCSQQDIERSTRNGVHVWVEHGGIVGRGVLLDYKAWAEAHGQEVDCFDTQSISVSTLQEVARSQRVTFQTGDILFVRTGWTQSYKQLSPVECQQLADYKTPPVIGVESSKETLRWIWENNFAAVAGDMPSFEAWPPQKPDFFLHEWLLAGWGMPIGELFDLERLSQECRQRQRWTFFFSSVPLKVPGGVASPPNGIAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X4U9</accession>
    <name>A0A9W9X4U9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000007">
        <property type="protein sequence ID" value="KAJ5483887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789157.1">
        <property type="nucleotide sequence ID" value="XM_056935689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X4U9"/>
    <dbReference type="GeneID" id="81625938"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5483887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="110" mass="11943" checksum="2D4386EE275C9547" modified="2023-11-08" version="1">MSLVLFVQIPVAANWATRGILRLASRSANGAEACRGCHEGEPGNKLLIKQMQEGFENVTLISVGRQNFSLHLKHETRQAQRASSTLATSALHEYDHKDGRLNAGGMVAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5A4</accession>
    <name>A0A9W9X5A4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_005923</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789397.1">
        <property type="nucleotide sequence ID" value="XM_056935525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5A4"/>
    <dbReference type="GeneID" id="81625774"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040860901" description="endo-polygalacturonase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5484127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="380" mass="38753" checksum="C86FFD124833B6EF" modified="2023-11-08" version="1">MVFSLKLCLVGLASAAAVQAIPNTMPELDVIATSSLEERASSCTFSGASGAAAAIKAKNTCSTIVLSSVAVPAGTTLDLTGLRQGTTVIFEGTTTFGYKEWTGPLVSISGTDITVTGASGSVLDGDGARWWDTKGSNGGKKKPKFFAAHNLINSKIQGLTIKNSPVQVFSINGAQALHLDNITVDNADGDSKGGHNTDAFDVGSSTGVYITNPIVHNQDDCLAVNSGTDIHFTGAQCVGGHGISIGSVGGRSDNIVSKVTVQGCTIKDSENGVRIKTVYGATGAVKDVTYQDITLSNISKYGIVVEQDYENGSPTGKPTAGVPITGLTLNNVKGSVSSKATNIYVLCASGACSGWNWSGVSVTGGKTSAKCLNVPGSAKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X605</accession>
    <name>A0A9W9X605_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_005022</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789818.1">
        <property type="nucleotide sequence ID" value="XM_056934624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X605"/>
    <dbReference type="GeneID" id="81624873"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000069">
        <property type="entry name" value="ER associated DnaJ chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
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        </source>
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        <source>
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        <source>
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    <sequence length="359" mass="39652" checksum="F2AB8FB4C28600DE" modified="2023-11-08" version="1">MPSATASGSDAKGGSARSREHNQGNQDRAYTPEQKAAVLRIRKCGPTDFYEILAIEKTATDSEIKKAYRKLSLLTHPDKNSYDGADEAFKMVSRAFQILSDSDKKSRYDRFGGDPESRFNPGPSASSGGSPFSGFNGGGGFPRSAGGGAAFDAEISPEEMFNRFFNGGFGGGGFGPFAGPQFVFNMGGGPGFRVHQFGGGVPRRRPRPTAGNNNNEPETPMDGWGFVRQLLPLILLFVLPLLSSLLTGSSTPAGPTYRFDSPVSPHTMGRTTPRLNLNYFVNPVDVEDYSARKFRQLDQRVEVDYIARLRHDCESEVHMRERMIQEAQGWFFPDVEKMKEARALELKHCRRLEQLKGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </dbReference>
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        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5484720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
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    </evidence>
    <sequence length="116" mass="12746" checksum="D7DAC17255318A0B" modified="2023-11-08" version="1">MWLAGLGVWAFPKGKPCAASVHDRMMISIEVKPDPLLHQIADTSVPVPVAWAMVSLRKGLISIREIYMPNSQAKSRGRLCVYGSRPSDATERAEVPSLVDQQSLHADDPSDVLSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7G7</accession>
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        <recommendedName>
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    </gene>
    <organism evidence="3 4">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAJ5485692.1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF8">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5485692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="29158" checksum="FB5F707BF3A7F9ED" modified="2023-11-08" version="1">MEKSTQSGPASDLEASTTTPQTPQRSTFAQRWRQNLDPTNADLVCLVLCFLTGLCDSSAYNAWSCFLGMQTGNTIFLGLGASNQPVSKPWGWLKSLISIVFFFSGAMIFSAVMRRVGALRRGTLFVSFMVQTILIIIAVAIIQADLIPHSSTDMGLTGGPLFLELIPIGLLAFQSAGAMTCSRSLGYNEIPTVVLTSVYFDIASDPKITDKPTGNVKRNRRVGGVVCLLIGAIVGGWLSRSSGGMQSALWMAAGIKLVAAVGWLFWRAAPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCV0</accession>
    <name>A0A9W9XCV0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">S-adenosylmethionine mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_003832</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790975.1">
        <property type="nucleotide sequence ID" value="XM_056933434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCV0"/>
    <dbReference type="GeneID" id="81623683"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000112">
        <property type="entry name" value="Mitochondrial carrier protein (Pet8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000123">
        <property type="entry name" value="Solute carrier family 25 (Mitochondrial S-adenosylmethionine transporter), member 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="13"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="109"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="248"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5488942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="348" mass="36528" checksum="12C348D0E4679775" modified="2023-11-08" version="1">MTQPGDGEPLVSSLWTRSLLSGAVAGLTVDCSLYPLDTIKTRLQKARDLSTPQAPRLSLRQTIRGIYAGLPSVLFGSAPSAASFFIVYDGVKRSLLPPSNSSDTPSTTHVFLTHSLASSLGEISACAVRVPTEVIKQRAQAGLFGGSSLLALKDILSLRHEVPHTPGSAGSSAAASTATLKRGYGQVIRELYRGAGITIAREIPFTVLQFTMWESMKATYAQRYLRAGDVSGSSSSPSAPMAQIPASTSAMFGSVAGAIAAGLTTPLDVIKTRVMLARRGDGGSAPVRVKEIVRGIAQEGLGAFWRGIGPRVAWIGIGGAVFLGSYQWAWNTLEGAKERDDGHLGSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCZ4</accession>
    <name>A0A9W9XCZ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase DMA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_004015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791158.1">
        <property type="nucleotide sequence ID" value="XM_056933617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCZ4"/>
    <dbReference type="GeneID" id="81623866"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000030">
        <property type="entry name" value="FHA domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE DMA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="220"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="360"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="427"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="141"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="512"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5489125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="581" mass="62228" checksum="E62B105253E63310" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XD45</accession>
    <name>A0A9W9XD45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="5 18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">N7539_004094</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 23">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="18">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="18">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 18"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791237.1">
        <property type="nucleotide sequence ID" value="XM_056933696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XD45"/>
    <dbReference type="GeneID" id="81623945"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="16 18" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="19">
        <location>
            <begin position="55"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="176"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ5489204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="272" mass="31046" checksum="3B2F7DF77D114B9E" modified="2023-11-08" version="1">MASLRTTSRLFAASRPLFRPASFARTYATVDSNVSETPKMKTFKIYRWNPDTPTEKPTMQSYELDLNKTGPMMLDALIRIKNELDPTLTFRRSCREGICGSCAMNIDGVNTLACLCRIPTETTKESRIYPLPHTYVVKDLVPDLTLFYKQYKSIKPYLQRDTPTADGLENRQSPEDRRKLDGLYECILCACCSTSCPSYWWNQEEYLGPAILLQSYRWLVDSRDEKTAERKAALDNSMSVYRCHTILNCTRTCPKGLNPGRAIAETKKMLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XD78</accession>
    <name>A0A9W9XD78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="4 11">2.7.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_004120</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the APS kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="4 11"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791263.1">
        <property type="nucleotide sequence ID" value="XM_056933722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XD78"/>
    <dbReference type="GeneID" id="81623971"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000212">
        <property type="entry name" value="Adenylyl-sulfate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5489230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="211" mass="23627" checksum="F13087388DD290C8" modified="2023-11-08" version="1">MATNITFHAAALTRKERNDLRQQQGLTIWLTGLSASGKSTLAVELEHQLLRDRGVHAYRLDGDNIRFGLNKDLGFSEADRNENIRRIAEVAKLFADSSAIAITSFISPYRKDRDSARQLHEVPTPGEETGLPFVEVHVDVPVEVAEQRDPKGLYKKAREGVIKEFTGISAPYEAPEKPEVYIRNVDLAIPDAVKQIIDYLDSKGYLPAKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEB2</accession>
    <name>A0A9W9XEB2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-dehydroshikimate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791804.1">
        <property type="nucleotide sequence ID" value="XM_056934263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEB2"/>
    <dbReference type="GeneID" id="81624512"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF21">
        <property type="entry name" value="XYLOSE ISOMERASE-LIKE TIM BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="2">
        <location>
            <begin position="49"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="366" mass="40845" checksum="8E91A02EDCE349D2" modified="2023-11-08" version="1">MADELGPSAHPTSMSDLPTPPAEPDPRWTPAIATVSLGTAEFHTLPAKIEAAAQNGQRGLELFHDDLAQFAKSLRASSGSQAAARTDRDFEIDAAHAIRELCEQKGLQVLALQPFRQFEGLLNAVEHANRIEELKHWTNLCLILGEDLFILIPSSFLDASQITGDRDRLVSDLAEAADVVFPVRIAYEALAWGTYINTWEDSWEIVKRANRPNLGICLDTFNIAARIWADPTSPTGRLQAHADTDLTESMHRLVREVDPDRVWMVQLADGERVDPQAPFLQVPGMPKLLSWSRNARLFPCEEERGGYLPIRQVTDACLSRLGYTGWVSMEVFSRSTMEAQPSVPNDHAARAARSWRRMLQQLDSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEJ6</accession>
    <name>A0A9W9XEJ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_002279</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791841.1">
        <property type="nucleotide sequence ID" value="XM_056931882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEJ6"/>
    <dbReference type="GeneID" id="81622131"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09001">
        <property type="entry name" value="GH43_FsAxh1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF15">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040783521" description="CBM1 domain-containing protein" evidence="7">
        <location>
            <begin position="17"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="8">
        <location>
            <begin position="540"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="519"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5490712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="576" mass="61610" checksum="9726E7EFD2AA122F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEM6</accession>
    <name>A0A9W9XEM6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2 type master regulator of conidiophore development brlA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_002341</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791903.1">
        <property type="nucleotide sequence ID" value="XM_056931944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEM6"/>
    <dbReference type="GeneID" id="81622193"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000845">
        <property type="entry name" value="C2H2 type conidiation transcription factor BrlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="12" id="KW-0183">Conidiation</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0749">Sporulation</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="351"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="211"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="225"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5490774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="431" mass="48677" checksum="E59B2E86638CD331" modified="2023-11-08" version="1">MRSQGQQISDRLTVEVDCHSLGPVDCPSMTSSFSPLESPTPTPTSLYSHGSLASPGWHDGGHYHSLPMERRTSATPLRNAFRITDFPSADPMGMQVSTMDRQEQLPISSEYLSGYDDINDQLWIPHDSIPKTFEQPSFPYQAPMPQYHHTMGRNHYYRPHAQSAYLPESASNPCLSRPMFSHHDRLPNSASMSNMLPWMTAPESLAPQTITPQQAFPGAGPVTPPSSNYSDFPASLQTFKQHTPSTPVRSLSLGTPRSDTPQSRLSAHHDYSEEYPVSPVYRDGHMVCTHRQPSRKPSKKQLLRSHLSLEKLPPIIKQVQFKCKEPGCKGRFKRQEHLKRHMKSHSKEKPHVCWVPGCHRAFSRSDNLNAHYTKTHSKRGGRNRYVATLDETSPDYDPEFRGQLTPDGRPIYGSKLEELPDCDLSVDGWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEN3</accession>
    <name>A0A9W9XEN3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056931959.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81622208"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:microtubule anchoring at mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Centrosome-WD_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220">
        <property type="entry name" value="WD REPEAT PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN WRAP73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5490789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="484" mass="52757" checksum="2CC735488EA2E13C" modified="2023-11-08" version="1">MDASTGPGVALTINLSADGLYAAQINGKDLVVYNDLTSANRDAQVCRLKENGVKYIKFSQRCVSMPATNNGQTRFLLTANDSRITAWQLNPLQVLGEIENLEPGTLAVDFGKSGQEILVFHAWNTKLTIHSLETGQSSVIKSPKSASHLGFGYRPVTRHLAILLKHDMSDLLTIHEPRSHELLGRVTLSTVDAQGLKWSPDGNWIAVWDAAMAGTRVLILTADGQIYRTYHGSPDDDDPFDLGVRHIEWAPSEGAGEASRFLAVGKVNGSIDLLGTRTFSLSTTLSHIFAADTQTSLFWRERFTSAMGDGDYTETSSSSAANMSPESPSSARGVSIMTFSSDGGHLATVDSTRSNVVWIWAMNPTPQLTSVLVHEQPVRQLLWHPATPQLLINTITTSLPSIRWWSPNTRPVIARVPTHKSESGKYDVKWLAESEPDSAFWFGSTEEYVVGYLSAEDGPSVKFEVITSVTSQGYGKPEGCVTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEW3</accession>
    <name>A0A9W9XEW3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792114.1">
        <property type="nucleotide sequence ID" value="XM_056932155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEW3"/>
    <dbReference type="GeneID" id="81622404"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5490985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="184" mass="19861" checksum="805E1AE66A6DE685" modified="2023-11-08" version="1">MCGESSPRPASGGTIAVLFPPQDITSSVKDSPDSPERCLSSSPESIASTTSCSSLPTKMSSYSLFFRDSDHCHPDGQSQTTRVIFHFSDCDTYQALCGEREVQMRIETHGDLSSSTQGLTPLHVFRLKLSHSLRKRASKGRAEVEVHLAEKLDLNVSTRGVVGRQVSLCDADGVLLGTGIIGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEW8</accession>
    <name>A0A9W9XEW8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_002523</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792085.1">
        <property type="nucleotide sequence ID" value="XM_056932126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEW8"/>
    <dbReference type="GeneID" id="81622375"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="4">
        <location>
            <begin position="409"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="352"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5490956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="519" mass="58753" checksum="A52A032774372835" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF24</accession>
    <name>A0A9W9XF24_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002503</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792065.1">
        <property type="nucleotide sequence ID" value="XM_056932106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF24"/>
    <dbReference type="GeneID" id="81622355"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1340.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020608">
        <property type="entry name" value="RNA_pol_subH/Rpb5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007129">
        <property type="entry name" value="PRK09570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000747">
        <property type="entry name" value="RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01110">
        <property type="entry name" value="RNA_POL_H_23KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="7">
        <location>
            <begin position="14"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="6">
        <location>
            <begin position="162"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5490936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="235" mass="27107" checksum="0BAE611516CB4C13" modified="2023-11-08" version="1">MDADNFATSTDASREMSRLWRTWKTVHEMLVDRGYEVSEDELKLSLEDFARKYSDPIGYPDRTKMKIQARPTEEMKFKYTALPTKSNPNPQPDCGTIYVDFCPESSSLGAKQVRTFNHFVAENNFHTGIFITQVPLSPTAVRMLNSVPGHIGETFQEQDLLVNITRHELVPKHVLLSPEEKAKLLQRYRLKESQLPRMQVSDPVARYLGLRRGQVVKIIRKSETAGRYASYRWVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFB6</accession>
    <name>A0A9W9XFB6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Trafficking protein particle complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_002763</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792325.1">
        <property type="nucleotide sequence ID" value="XM_056932366.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81622615"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055505">
        <property type="entry name" value="DUF7077"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056916">
        <property type="entry name" value="NTS_TR130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022233">
        <property type="entry name" value="TRAPPC10/Trs130_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23274">
        <property type="entry name" value="DUF7077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24967">
        <property type="entry name" value="NTS_TR130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12584">
        <property type="entry name" value="TRAPPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24965">
        <property type="entry name" value="TRS130_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="6">
        <location>
            <begin position="349"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Trs130 NTS" evidence="8">
        <location>
            <begin position="628"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7077" evidence="7">
        <location>
            <begin position="924"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 C-terminal" evidence="5">
        <location>
            <begin position="1252"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        </source>
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    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24967"/>
        </source>
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        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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            <strain evidence="11">IBT 30728</strain>
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    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Penicillium diatomitis</name>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </dbReference>
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            <end position="564"/>
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    </feature>
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        <location>
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            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="5">
        <location>
            <begin position="948"/>
            <end position="1103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
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    <evidence type="ECO:0000259" key="3">
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5489742.1"/>
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    <evidence type="ECO:0000313" key="7">
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">N7539_003121</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
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    <reference evidence="8" key="1">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792683.1">
        <property type="nucleotide sequence ID" value="XM_056932724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG31"/>
    <dbReference type="GeneID" id="81622973"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="3"/>
            <end position="35"/>
        </location>
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        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="696"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5491554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="828" mass="93460" checksum="B037FC29B6FB8D99" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGB2</accession>
    <name>A0A9W9XGB2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 68</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_003256</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056932858.1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    </dbReference>
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            <begin position="21"/>
            <end position="41"/>
        </location>
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            <end position="125"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5491689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="173" mass="18842" checksum="CF3C55D8D16B3164" modified="2023-11-08" version="1">MDVSSNRLFRFSKPEWLNNSAVRNAGVYASGALFAAGFFFLIDVASFSHSARNGSDVHIKFVDWIPGICSALGMLVINSIEKSRLQADSFSYSGGGVAWKARFVLFLGFALLAGGLAGSVTVMVLKYLVKEYPIQTLYFGIANVVANGLVMLSSVVLWVSQNMEDDYTYNLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGJ0</accession>
    <name>A0A9W9XGJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oleate hydroxylase FAH12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_002764</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792326.1">
        <property type="nucleotide sequence ID" value="XM_056932367.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81622616"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="3">
        <location>
            <begin position="126"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5491197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="468" mass="52298" checksum="F603ABC2308F26FA" modified="2023-11-08" version="1">MSSTALPKRVALHRNPATDSSMPSSVSASPFDSPRQSPSSTSLSSMGSEPEVQTKMLDTYGNEFKIPDFTIKQIRDAIPAHCYHRSAVTSLYYVFRDMAILASVFYLFHNYVTPETIPSMPLRVALWTVYTVIQGLVGTGVWVLAHECGHQAFSPSKVLNDTVGWICHSLLLVPYFSWKISHGKHHKATGNLARDMVFVPKTRSDYATRIGKTIYELSELVEETPIATATHMVGQQLFGWILYLLTNVTGHNNHEKQPEGRGKGKKNGWGGGVNHFNPSSPLYEAKDAKLIVLSDLGLLMTGSILYYVGSTYGWMNLLVWYGIPYLWVNHWLVAITFLQHTDPTLPHYEPEVWSFARGAAATIDRDFGFVGRHIFHGIIETHVLHHYVSSIPFYNADEASEAIKKVMGSHYRTEAHTGWTGFFKAMWTSARACQWVEPTEGARGESKGVLFFRNTNGIGVPPTKITAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGZ6</accession>
    <name>A0A9W9XGZ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein RTM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_001562</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793196.1">
        <property type="nucleotide sequence ID" value="XM_056931165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGZ6"/>
    <dbReference type="GeneID" id="81621414"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5492816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="206" mass="23296" checksum="2836C0475D4CE4A5" modified="2023-11-08" version="1">MFLGRIILVLQAESHALKKKWLTKVFVTGDVLPFLLQGAGKSKKPQVKVEGNWGYIRSPRLIESLSSGGIQSNGSLEGVKTGEHIIVAGLVIQILFFAFFIVTATHFDRTLMKYPIPRARSPSIPWRRHLNILYLTSGLIMIRSMFRLIEYAQGNGGYILHHELCLYIFDSLLMFLTMIIFNVVHPQEIGQLLSHPVQYEMTAGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHB0</accession>
    <name>A0A9W9XHB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_001722</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793356.1">
        <property type="nucleotide sequence ID" value="XM_056931325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHB0"/>
    <dbReference type="GeneID" id="81621574"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF37">
        <property type="entry name" value="LD47843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="40"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5492976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="612" mass="66004" checksum="36BDDF10897DAB68" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHG1</accession>
    <name>A0A9W9XHG1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Cutinase</fullName>
            <ecNumber evidence="3 12">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_001817</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cutinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3 12"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793451.1">
        <property type="nucleotide sequence ID" value="XM_056931420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHG1"/>
    <dbReference type="GeneID" id="81621669"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF2">
        <property type="entry name" value="CUTINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 12" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040999777" description="Cutinase" evidence="14">
        <location>
            <begin position="16"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="113"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="117"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="230"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="359"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5493071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="399" mass="37134" checksum="6A9DFBF18AA2AECC" modified="2023-11-08" version="1">MKTVVALTFVGAALAAPTKTIESRTLGDLGSGLGGLGSLSSLGSGLGGLGGASSGSSTGSGFGALTSLIPSVGNLGSLGSLGGLGGSSGSSGLGSLGSLGSLGSLGSGLGGLGGASSGSSSGTSSNTGASGSSTVDASASASASASADASSNASSGSSVGGSGSSGSSGLGSLGSLGSLGGLGSLGGLGSGSKNSSSGSEVAGSGSADGHTKRQFTGSVTANDVTNKASCKELTFIFARGSDEIGNMGSVVGPPVASQLQSLTGNKVNVQGVDYAATAASNAALGANGGPVMANLVETALKQCPDTKVVIGGYSQGSMVVHNAANSLGADKVAGAVLFGDPFKLQAVGKLPQNKVKEYCALGDPVCENGANVMAHLSYGSNAKEAAQFLLQAAGISASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHM3</accession>
    <name>A0A9W9XHM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_001526</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793160.1">
        <property type="nucleotide sequence ID" value="XM_056931129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHM3"/>
    <dbReference type="GeneID" id="81621378"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF40">
        <property type="entry name" value="THIAMINE PATHWAY TRANSPORTER THI73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="44"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5492780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="381" mass="42470" checksum="72698E237A77E3D7" modified="2023-11-08" version="1">METKDELLSHGKADAALEFLRDEGCGIAVEINEKTLVRKIDWMIMPLMWAAYNLQYLDKVLINYASVMGLLEDTNMRTNQFSNLALAFYVTYLVFELPTGCLMQRLPTAKYLGVNVILWGLMTTLNCSAKNFGGLMTLRVLLGCFESAIAPALILITSMWYKRNEQPTRMGIWYIGTGTASIMGALVAYGLLFYTNHVFKSWQIMFLIFGLITIVVGVCICIFMPDNPMKSKLTHDEKVFAIERLRENLTGIENKHFKWCQFFEVFKDPLTYLIALIVTAMDVPNAAVSSFTSLIIENIGFTTKETELLNVPNGVVSIISILVVTNIASRYDQRCLSVIIALAGGLLGSCLLAFSPKSLKAAQLAGNYLTQMTGSALPLMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI28</accession>
    <name>A0A9W9XI28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793149.1">
        <property type="nucleotide sequence ID" value="XM_056931118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XI28"/>
    <dbReference type="GeneID" id="81621367"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF5">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="2">
        <location>
            <begin position="8"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5492769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="103" mass="11423" checksum="D2C471CDC31F5A99" modified="2023-11-08" version="1">MDTEKAVSYLSGLLGRTLRIHASDGRMFVGLFKCTDADRNIILANSFEYRMPSASAVQEAAAKETESWDETQVKATRVKVNMSSRLIGLIVVPGHHITKIELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI74</accession>
    <name>A0A9W9XI74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Free methionine-R-sulfoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the free Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793713.1">
        <property type="nucleotide sequence ID" value="XM_056931682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XI74"/>
    <dbReference type="GeneID" id="81621931"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033745">
        <property type="term" value="F:L-methionine-(R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000048">
        <property type="entry name" value="Free methionine-R-sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000614">
        <property type="entry name" value="FRMsr_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF15">
        <property type="entry name" value="FREE METHIONINE-R-SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01320">
        <property type="entry name" value="UPF0067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="101"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5493333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="206" mass="22276" checksum="6543A4A12402F886" modified="2023-11-08" version="1">MPHADSSYFWGKTKAEVYSQLLDQAKGLLDGQRNWVSVNLSNISSLLWHAYAALPSPSSAVNWTGFYIRDDKFPALASPVSSPPLPGAPGFGGVTISTTYAHPEDQILLLGPFHGKPACQQIRFGKGVCGTAAANQKTVIVPDVMKFPGHIACDADSRSEIVVPIIIRGETVAIIDIDCTLPSGFDEEDQQYLEQLAELLAESCDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI81</accession>
    <name>A0A9W9XI81_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sialidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793856.1">
        <property type="nucleotide sequence ID" value="XM_056931825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XI81"/>
    <dbReference type="GeneID" id="81622074"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792">
        <property type="entry name" value="BNR/ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792:SF3">
        <property type="entry name" value="BNR_ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="41816" checksum="5660EAB7EDE56344" modified="2023-11-08" version="1">MPGHFKQKVLNALGMNQHAGSPQDQSLPPGVVTHQPSRERVQVQIQDDERPLTSGPNNGTYPRLTRLADGSLLSSVTQFPDGQNALRIARSTDGGRTFHEYAEVTRATGEIDNLFLLEVIPGTVLAAFRNHDKGPEGFTHFRITVCRSTDGGRTWHYASQAAEKSPPWGIWEPFMRIGREGEVQLTYSLEYAHNNQCTMLVVSHDLGSSWSGPVCLYGREEPLRDGMNGIATTFDNGREVLIMVFETTRYGPFSIEALVSYDDGASWQDRQEVFRPRPEHNAGAPQISAFADGSLAVVFMTDDDSQQVDWVQHASIKAIFADPPQNGRISWSEAYLVSPESSFWPGVFALDQHTALVTYDRGGPLVKTILRGILDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIH3</accession>
    <name>A0A9W9XIH3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793525.1">
        <property type="nucleotide sequence ID" value="XM_056931494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIH3"/>
    <dbReference type="GeneID" id="81621743"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF25">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="157"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5493145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="493" mass="54380" checksum="FCBFC811F9C86E97" modified="2023-11-08" version="1">MSDYKYSAHLLKELIIRIPLVLKTLLLHGIQMSPGAGKQDLRTEITTAMIRSFMTFSAPVDKTQKNSMRDPGVKGPMWVSKVTLSRPEFDVRDAVVRAIEDLKTTGNETFALPPVADVEAEWTGFRSGVGKRTPQPDLSEEEKYQELRKESTSDMTILYFHGGAYFLMDPCTHRVPVAHLSRLTGAPILSVRYRLAPQNPFPAALVDALTAYLSLIHPPPGSLHKPVPANKIIIAGDSAGGNLSLVLLQTLLTLKRASRPVRFHGQDVDIELPGGVALISPWCDLTHSMPSIVNNLKFDYLDMKGTPSEDPEEPTAISSAPFPPGSVWPVDPPRLNMFTDANMMLHPLVSPMAAKPELWEGAPPVLISTGEELLTDESFVVARRMHRAGVNVVVDQFEGMPHCHAMIMMSTATGKQFFKNVAGFCLDAAAGRVKSTGQVNWYGQGLKTSREIPLAEVVDLDEDRVDARMSKSASWLVRDEEALRKEWRAQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIU2</accession>
    <name>A0A9W9XIU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Saccharopine dehydrogenase [NAD(+), L-lysine-forming]</fullName>
            <shortName evidence="14">SDH</shortName>
            <ecNumber evidence="5 14">1.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Lysine--2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">N7539_001905</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>L-saccharopine + NAD(+) + H2O = L-lysine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="EC" id="1.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.7" evidence="5 14"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793539.1">
        <property type="nucleotide sequence ID" value="XM_056931508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIU2"/>
    <dbReference type="GeneID" id="81621757"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12188">
        <property type="entry name" value="SDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000217">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000627">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027281">
        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF23">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE [NAD(+), L-LYSINE-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018250">
        <property type="entry name" value="Saccharopine_DH_Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 14" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="19">
        <location>
            <begin position="7"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="18">
        <location>
            <begin position="175"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="203"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="321"/>
            <end position="324"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="205"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR018250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ5493159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="376" mass="41006" checksum="B8C9794B2BAD2EBD" modified="2023-11-08" version="1">MAGQKIWLRAETKPAEARSALTPTTCKALIDAGYDVTVERSTQRIFDDDEFAQIGAPLVEEGSWVKDAPKDAVILGLKELPEDDFPLEHVHVTFAHCYKQQGGWENVLSRWHRGKGLLLDLEFLTDESGRRVAAFGFSAGYAGAALAIKNWAWQLTHPEGEVLPGEVPYANQDLLIASVKESVEAGKKIAGHYPRILVIGALGRCGKGAVQLAKDVGVPESNIIQWDMAETAKGGPFNEIIQSDIFVNCIYLSSPIPPFVNVETLSSPSRKLSVVCDVSADTTNPHNPIPIYDITTTFDKPTVPVTLPAGTQGPPLSVISIDHLPSLLPRESSEQFSQALLPSLLQLKDRHTARVWVQAEELFNEKVATLPASMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIV4</accession>
    <name>A0A9W9XIV4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-acetyl-6-hydroxytryptophan oxidase ivoB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_002101</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793735.1">
        <property type="nucleotide sequence ID" value="XM_056931704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIV4"/>
    <dbReference type="GeneID" id="81621953"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00264">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TYROSINASE"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5493355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="302" mass="33560" checksum="69124C3705D8CCEE" modified="2023-11-08" version="1">MSLRSGSDEQPNLILALISRGELSPAERIHYTDAVRCLMRLPPKLAAVGSFPGVRSRFDDFVATHINYTLNSHYSGLFLPWHRQFLWLFEQALRDECNFEAHLPYWNWPLWAGRLAESPLFDGSDTSLSGDGSYNPAEQDISGGDVTLPRGSGGGCVKDGPFKNTIINLGPFPRTILSLTEIPAPQFDYNPRCLNRSLNNFVSAHLTNQAHVASLLATPDIASFQLTLDHWPASPSGVLGLHGGGHLSLGSTMQDLFSSPQDPAFMLHHAMIDRLWGIWQTADEEHRRARDSWDEDGIWDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XL67</accession>
    <name>A0A9W9XL67_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_000024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793921.1">
        <property type="nucleotide sequence ID" value="XM_056929628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XL67"/>
    <dbReference type="GeneID" id="81619877"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF194">
        <property type="entry name" value="INVERSIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5494908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="467" mass="51678" checksum="B7A1B45D5456C08B" modified="2023-11-08" version="1">MTATQLLGLPAEILYAIADNFEYASDLNNFTQTCRHVYSVLTPRLEHSFMPAPTPENIHHIIIEGNTLSLARMLSLKSVQDVQMANVLSLGRMASEHCQFKILELLVELYGSAWYIEDVLDHAADWCPVLDEALRQDCSKLLETLNVHLSSRPGDSNRMIRLLNAATSGGLTALVVYLASRARDKNLGTFSFAARFNPPLLTAASSGQLTCLRSLIEGFCISSDTSQSRTPLKIQDQFLLLASRLIYVAAASGHDEVVRYLLQTNAVDVLRENPDIEGLNECFLKSSDVSRELTVDLFHGLPDIETLNGSSLRSFHISNESAVELILAELRDLSFHMSTPEGKAHPRAFLWAIFTNNIIFVQRLLESGHVPQDEPGNTPALALRRGLNLAIRRCHVNICELILAKLTTANAPIGTSQYMEHLSLALATKNASIARVILHAGTDLCCLPLRRIKFQRLLKLCWIAAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLB4</accession>
    <name>A0A9W9XLB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HPP transmembrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794087.1">
        <property type="nucleotide sequence ID" value="XM_056929794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLB4"/>
    <dbReference type="GeneID" id="81620043"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="2">
        <location>
            <begin position="56"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="292" mass="32431" checksum="309E8B04E47C311C" modified="2023-11-08" version="1">MSHTLHGPMKLSDVRTWHVDIDRFINPWLPAPRLHRLPRPISRFLGYRERPPRPLGNVVIAFWSLVGAFCGVAVIAEVSKRIPSFESRDTPAVVGSFGAAAVIEFCAIQSPFAQPRNAFFSQMWACLVGVGISKLFALNPNAEQYTSLGGALACALTTAAMLLTETIHPPAGATALLAVTNAQMASLGWFLFPVMILGCILMQAVALIVNNIQRQFPLYWWTSHPLSRSQIADEEKEGIHREPAPTIPDHYEESLTDTPRRMVIERGEIFVPEGVYLSMTEKEVLEKISERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLH3</accession>
    <name>A0A9W9XLH3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_000347</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794244.1">
        <property type="nucleotide sequence ID" value="XM_056929951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLH3"/>
    <dbReference type="GeneID" id="81620200"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="32"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5495231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="508" mass="57347" checksum="4D9777EA368026D3" modified="2023-11-08" version="1">MAPAAAHAAEGIASPINVDLMQPFWRRKNGILLYFLLTSSLLASAALGIDGALLNSWQDRFGHPEGAKLGFFGASNAIGGVIPFIFLSWIGDKWGRRLPTALGSVVIIAGVLIEFFATSLNMYIGGKIILGVGSSLIQMGAPVLVTELSHPKERVQVTTFYNTSIVLGYVIGAWATFGCYRINSQWSWRLPTLIQIFPSAYQFCLIWFCPESPRWLIAKGRVQEAREILIKFHGECDPNSELVEVECAEIQQAIIKEAENNMTWRDFFSSKANLKRIFLCFATALFSQSSGNLLVSNYLTQILKDTGLKTKYEITLVNGMVTLWQYIVAIFVTLIIDRFRRRFFFLTGSGGVLVTFIVWTIAAQQYLEHNSLAAGRLVIACIFIFQAFYTFAWTNLIVTYPLELVTLQMRAKAWAFVLLTIQVSSIFGSYVNPIALKNIGWKFYIYYCVWVFIVLLVVYFFFVETAGPTLEELAYPFEGEDAKKELVHQIQDRKQEISYEEHVEDKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLN8</accession>
    <name>A0A9W9XLN8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_000433</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794330.1">
        <property type="nucleotide sequence ID" value="XM_056930037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLN8"/>
    <dbReference type="GeneID" id="81620286"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5495317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="759" mass="83911" checksum="C30E8DAE6B2EB4A1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLW2</accession>
    <name>A0A9W9XLW2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_000557</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794454.1">
        <property type="nucleotide sequence ID" value="XM_056930161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLW2"/>
    <dbReference type="GeneID" id="81620410"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd03467">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
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        <property type="entry name" value="DUF455"/>
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        <property type="entry name" value="Rieske_2Fe-2S"/>
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        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
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        <property type="entry name" value="Sol_Rieske_ferrdox_dom"/>
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    <dbReference type="PANTHER" id="PTHR42782:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42782">
        <property type="entry name" value="SI:CH73-314G15.3"/>
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        <property type="entry name" value="Rieske_4"/>
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        <property type="entry name" value="ISP domain"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <end position="113"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="148"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5495441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="458" mass="50439" checksum="FAA3DB823D6D0A2A" modified="2023-11-08" version="1">MQINCGPLSAFTNPRYVIHLSTGKRLVLFRLAAIDPSCSKPNETQGWSYYAMEAECPHAGGPMADSSVDIEDSAYIVSCPWHAYDFNVETGESSVGIKACTFPVDVSDGDVLIDFPTEAGDAVGMSRVEPVSEKVKLKSKSNPTAAQSTGTSVSSVPTVAEPSNTTEAGPIQYLGDDATLCDWAVHILNTAHPEHKIELTTHLYNIFAAREGTASPMEIGRGTVTAPDQPRREKMIEVRPGGMPRTRKAGSVKSRIALLHALANIELWAIDLAIDICVRFSTFKTVESNPQELPRAYFHDWLKVARDEAKHFSLLRSRIEELGSYFGALPVHNGLWQSALETAYDLRSRISIIALVHEARGLDVNPLTIQKFRIAADLESVETLEIIHNDEITHVTTGHRWLTWICAQEGTDPVKIFRDNVSKHFRGSIQGPFNEEARLQAGMDRRYYGPTPTPVAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLW8</accession>
    <name>A0A9W9XLW8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Chromatin structure-remodeling complex subunit snf21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_000490</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_056930094.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:helicase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:chromatin remodeling"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXHc_SMARCA2_SMARCA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Putative chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Gln-Leu-Gln_QLQ"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
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        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029295">
        <property type="entry name" value="SnAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01314">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51666">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="QLQ" evidence="16">
        <location>
            <begin position="148"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="HSA" evidence="15">
        <location>
            <begin position="373"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="558"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="869"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="1272"/>
            <end position="1342"/>
        </location>
    </feature>
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        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="183"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="341"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1166"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1365"/>
            <end position="1430"/>
        </location>
    </feature>
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        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1197"/>
            <end position="1206"/>
        </location>
    </feature>
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        <location>
            <begin position="1387"/>
            <end position="1400"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5495374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1430" mass="163028" checksum="F884F594999AB367" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLX7</accession>
    <name>A0A9W9XLX7_9EURO</name>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP001148312">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5494930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="155" mass="16809" checksum="BA42B7B14435E9E0" modified="2023-11-08" version="1">MSGILAQWQASRAVLVVPMGDVQFLSFQKLAAIASAYGAILAHIPPQPLQPSPDPFAGDNNARYMMSRVAALYQQNRGYFPSADTVVVCAWFNGAVALPDQMEIMSSSLRQLGLNPIIRTYHVPGNRNIPGQGTVIAIKGANQPTPQIYVEDRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9W9XMS2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_000938</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794835.1">
        <property type="nucleotide sequence ID" value="XM_056930542.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81620791"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AtrR-like"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
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            <end position="162"/>
        </location>
    </feature>
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    </feature>
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            <end position="263"/>
        </location>
    </feature>
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        <location>
            <begin position="747"/>
            <end position="777"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5495822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="810" mass="89493" checksum="A1177B20C10C245F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMV7</accession>
    <name>A0A9W9XMV7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_001015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
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        </lineage>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794912.1">
        <property type="nucleotide sequence ID" value="XM_056930619.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81620868"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF72">
        <property type="entry name" value="HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="591"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1078"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="282"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="471"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1038"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5495899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1218" mass="134642" checksum="CEE0A79D46BAD27E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN27</accession>
    <name>A0A9W9XN27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_000631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794528.1">
        <property type="nucleotide sequence ID" value="XM_056930235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN27"/>
    <dbReference type="GeneID" id="81620484"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5495515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="64" mass="6718" checksum="0E5E100D136B6F9B" modified="2023-11-08" version="1">MSSVHLTDLTRQIESVVAAATDTQADDTNQLPGHSYQTGGIAMGLFDVAAQHTDASNEKTVTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XPC4</accession>
    <name>A0A9W9XPC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Splicing factor 3A subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_001246</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795143.1">
        <property type="nucleotide sequence ID" value="XM_056930850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XPC4"/>
    <dbReference type="GeneID" id="81621099"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2690:FF:000002">
        <property type="entry name" value="Splicing factor 3a subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5496130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="235" mass="27094" checksum="712F7D1C75B5F8DF" modified="2023-11-08" version="1">MDYQNRAGSKFGGGGVASHSATNADRRERLRKLALESIDLDKDPYFFKNHVGSFECRLCLTVHQNDGSYLAHTQGKKHQTNLARRAAREQREGKNQDPSTLPGAMGVQVKKQTIKIGRPGYKITKIRDPLTRQMGLLFQLQFQEITPGIVPRVRFMSAFEQKVEDPDKNFQYLVVAAEPYQTCAFKLQAKEIDRREGRYWTWFDEDSKEFWVQIMFKTEREERFSGVPGLAPTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XPT3</accession>
    <name>A0A9W9XPT3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795157.1">
        <property type="nucleotide sequence ID" value="XM_056930864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XPT3"/>
    <dbReference type="GeneID" id="81621113"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5496144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12416" checksum="193256A1C53D3E13" modified="2023-11-08" version="1">MSNPINRDSEDVYERESDQSRVNRAFADTSYVTGANQDQDEIVPVQSDDQPVEDPIDPATADTNRQLRQDEREAVNESNILQGDRLRHTRPVTSNRYNEGPEESDIPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ61</accession>
    <name>A0A9X0BJ61_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="5">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF6</name>
        <name evidence="6" type="ORF">N7539_009437</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJ61"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5466708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="246" mass="26292" checksum="47AF01CC3E7DA9BD" modified="2023-11-08" version="1">MAVRAQFENSNEVGVFARLTNSYAIVAVGASENFYSVFESELQDVIPICHATIAGTRIVGRLTVGNKNGLLVPTTTTDQELQHLRNTLPDAVKIQRIEERLSALGNVICCNDHVALVHPDLERETEEIIADVLGVEVFRQTVADNVLTGSYMALSNQGGLVHPKTSIRDQDELSSLLQVPLVAGSVNRGSPVVGAGMVVNDWLAVTGLDTTATELSVVESVFRLGEMAPGGSGAGVNKESIVESFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJH9</accession>
    <name>A0A9X0BJH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="20">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">N7539_009213</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 20">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="18">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 20">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Mitochondrion inner membrane</location>
            <topology evidence="1 20">Peripheral membrane protein</topology>
            <orientation evidence="1 20">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="20"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786185.1">
        <property type="nucleotide sequence ID" value="XM_056938808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJH9"/>
    <dbReference type="GeneID" id="81629058"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000482">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:001062">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 18 20" id="KW-0274">FAD</keyword>
    <keyword evidence="6 18 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 20" id="KW-0813">Transport</keyword>
    <keyword evidence="5 20" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="21">
        <location>
            <begin position="62"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="22">
        <location>
            <begin position="512"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="67"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="456"/>
            <end position="457"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="19">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
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</entry>
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                <person name="Frisvad J.C."/>
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<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787000.1">
        <property type="nucleotide sequence ID" value="XM_056937908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNI5"/>
    <dbReference type="GeneID" id="81628158"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5475242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="86" mass="9584" checksum="7677821971AEED56" modified="2023-11-08" version="1">MGSAQDQTSKSARLQNDYGADYWIRNKETHRHATAGRGLFAGLQDVKSYNVEQGWARRKSGESQTGLLGSIWNRFIGANYHPPTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNQ3</accession>
    <name>A0A9X0BNQ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">C2H2 finger domain transcription factor crzA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_007313</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="81627163"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000146">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000181">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000239">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF13">
        <property type="entry name" value="RESPIRATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="529"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
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        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
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        <location>
            <begin position="192"/>
            <end position="236"/>
        </location>
    </feature>
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        <location>
            <begin position="378"/>
            <end position="523"/>
        </location>
    </feature>
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        <location>
            <begin position="632"/>
            <end position="669"/>
        </location>
    </feature>
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        <location>
            <begin position="701"/>
            <end position="738"/>
        </location>
    </feature>
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            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
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            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
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        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
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        <location>
            <begin position="639"/>
            <end position="649"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5477169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="770" mass="82598" checksum="6C9CD7C2AE9E3F6D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNT3</accession>
    <name>A0A9X0BNT3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pheromone</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="2819901"/>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040813916" description="Pheromone" evidence="2">
        <location>
            <begin position="19"/>
            <end position="181"/>
        </location>
    </feature>
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        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5477259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="19029" checksum="0AAC97E3E9B85847" modified="2023-11-08" version="1">MKFVSIALALMAATAVSAAPGRTMQKWCGHPGQGCVKRSAEPAPVAVAEPAPVAVAEAAPVPEAGRTMQKWCGHPGQGCAKRSAEPEPVPAPGRTMQKWCGHPGQGCYMMKRTADVTFEVKRSAEALAEAMAEAHPAALQKWCAHPGQGCQKVKRTADAVEEVKRSAAALEEAIASMEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNW4</accession>
    <name>A0A9X0BNW4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_007317</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787717.1">
        <property type="nucleotide sequence ID" value="XM_056936918.1"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:regulation of cell growth"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TOS3"/>
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    <dbReference type="Pfam" id="PF00069">
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        <property type="match status" value="2"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
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        <location>
            <begin position="247"/>
            <end position="721"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        <location>
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        </location>
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            <dbReference type="ARBA" id="ARBA00048679"/>
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            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5477173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1207" mass="132497" checksum="95F78C3A15185B3D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BP85</accession>
    <name>A0A9X0BP85_9EURO</name>
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            <fullName evidence="1">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">N7539_007511</name>
    </gene>
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        <name type="scientific">Penicillium diatomitis</name>
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            <authorList>
                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="47"/>
            <end position="122"/>
        </location>
    </feature>
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        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5477367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="185" mass="20222" checksum="4A274649338AC471" modified="2023-11-08" version="1">MRLPYVPNPPPTHTPEETRILEAVQARRAPNPLLPLDLTLLHSFPVTDGWNSFIGAIRTRTSLSAVIRELAICRVAVVNGALFEWEQHAPLLSEGGLSDEALELIGDAKADFEGPRAAELLAPDQRAVAQYTDAMTKTVTVSDEVFAQVKSCFNDKEVVEITATIAAYNCVSRFLVALDVGEKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BPD0</accession>
    <name>A0A9X0BPD0_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056937232.1"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="46"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="124" mass="13572" checksum="18D989E66165FCF2" modified="2023-11-08" version="1">MYQQQSVGRPASKSAVLLVKDENDSSWRECRRPTTANVLRSRECVAPGSEVEKTDRAASSKDACEDKLWSKDEEREDDAILPGTNGPTSPSVVLGRGKEDRMIARCSPRMRSEGLRTTGSVTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BPJ2</accession>
    <name>A0A9X0BPJ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="16">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_007645</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">May mediate the reduction of outer membrane cytochrome b5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="16"/>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788045.1">
        <property type="nucleotide sequence ID" value="XM_056937246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BPJ2"/>
    <dbReference type="GeneID" id="81627495"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF171">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15 16" id="KW-0274">FAD</keyword>
    <keyword evidence="4 15 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="17">
        <location>
            <begin position="72"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5477501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="323" mass="36029" checksum="093472A58188ADA0" modified="2023-11-08" version="1">MFARQAFRSAQPLKQGFRKYSTESAPKKANLTPVYVAVGLAGVGAGLWRYSSDSSSLPAAIKLEDRPKVFTGDWVDLKLAEIEILSHNTKRFRFEFDDPEAVSGLPVASALLAKYKPADAEKPVLRPYTPTSDEDTPGYLELVVKAYPGGPMSEHLHSMNVDQRLSLKGPLPKYPWEANKHQHITLIAGGTGITPMYQLARRIFKNPDDRTKVTLVFGNVSEEDILLKKELEELENTYPQRFRAFYVLDNPPKGWTGGKGFITKELLKTVMPEPKEENIKIFVCGPPGLYKAISGPKVSPKDQGELTGILKELGYSKDQVFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSA4</accession>
    <name>A0A9X0BSA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788173.1">
        <property type="nucleotide sequence ID" value="XM_056936238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSA4"/>
    <dbReference type="GeneID" id="81626487"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5480743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="102" mass="11616" checksum="95B0D6852F0DB113" modified="2023-11-08" version="1">MAPIPHAKLRPVQKPIVHERPAPPPLPRPAARPLNPADIRKTKEYKVAARRWLSSIVALPIVIYTSWILYERVYGDKQPKRLVMTEPAQPAQRFQSSQSESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSL4</accession>
    <name>A0A9X0BSL4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_006169</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788695.1">
        <property type="nucleotide sequence ID" value="XM_056935771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSL4"/>
    <dbReference type="GeneID" id="81626020"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5482723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="457" mass="49987" checksum="E922D27BEF358FAA" modified="2023-11-08" version="1">MPEMSQRPGKPTTSRFLRLESPVGSLTVAFLLWKFLLFVVVALCPGPGYDTSTSLLLHENAQSINKPLDGLSWPLKFARWDSIYFLPIAEKGYVFEQEWAFGYPRILSLVASAIRPSGGLTGPENMALIGIILSHASHYYSVLALYSLSTNIFGDDTPAQKLICFLSAALHIISPAGAFLSAPYGEPVFSLLNFVGLDLYTLSLIAEHRRSALLRDLQVLAAAVLFAIATVARSNGILSGCLFAYDAALLVWASLTQGLTIYNLRRLAVILVGGCIVATGIVVPQILAFNEYCVQSPEPRPWCQSQVPSIYGWVQSHYWNVGFLRYWTVSNVPLFALAAPMLFVLYKSSLWALKAPPTLGSKSTGVKSSQMSPGAMLIRLALPQVLLTVLAVTTYHVQIVNRIASGYPVWYWWLVSTAMPSFQDSRNSSRGLPRAAQAMVAYALIQAVLFGSFLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BTY2</accession>
    <name>A0A9X0BTY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789403.1">
        <property type="nucleotide sequence ID" value="XM_056935531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BTY2"/>
    <dbReference type="GeneID" id="81625780"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5484133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="58109" checksum="14435959428E4047" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BU92</accession>
    <name>A0A9X0BU92_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_005871</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789345.1">
        <property type="nucleotide sequence ID" value="XM_056935473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BU92"/>
    <dbReference type="GeneID" id="81625722"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000011">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="13">
        <location>
            <begin position="58"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5484075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="235" mass="26863" checksum="5DA581CF19A5E840" modified="2023-11-08" version="1">MGSNTPQWTPQSGKLYPSARLFKSRAETTNVLSPPVLSTVPHPPEENTTSPIPFFHLLERLKTTKREGWRRFGINGESISDHMYRMSIMTMFAPPELASRLNIPHCTKMALIHDMAESLVGDITPVDKDVTKTEKARREADTMDYITETLLGKIPGGALSAQEIKRVFHEYEDNVTLEAQFVHDIDKMELLLQMVEYERTHEVDLSEFTRVASRVQLPEIKVWAEQVMAERPKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BU93</accession>
    <name>A0A9X0BU93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_004745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789541.1">
        <property type="nucleotide sequence ID" value="XM_056934347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BU93"/>
    <dbReference type="GeneID" id="81624596"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5488756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="522" mass="56670" checksum="AE7015744E7FDCFE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXF8</accession>
    <name>A0A9X0BXF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Anaphase spindle elongation protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_003600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790743.1">
        <property type="nucleotide sequence ID" value="XM_056933202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXF8"/>
    <dbReference type="GeneID" id="81623451"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="737"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5488710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="771" mass="86424" checksum="EE689E55C1B87142" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXT2</accession>
    <name>A0A9X0BXT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="12">2.4.1.132</ecNumber>
            <ecNumber evidence="12">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_003975</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10 12">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11 12">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="12"/>
    <dbReference type="EC" id="2.4.1.257" evidence="12"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791118.1">
        <property type="nucleotide sequence ID" value="XM_056933577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXT2"/>
    <dbReference type="GeneID" id="81623826"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03805">
        <property type="entry name" value="GT4_ALG2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="14">
        <location>
            <begin position="18"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="13">
        <location>
            <begin position="238"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5489085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="480" mass="53395" checksum="262ECCB212C0A920" modified="2023-11-08" version="1">MPSSDSANVTIIHPDLGIGGAERLIIDVALALQNHGHRVTIYTSHCDKSHCFDEARDGTLDVQVRGNTIFPAHIFGRFHILMASLRQLHLTVSLLSELKQTMGSAKSTGSGDSDDIFIVDQLPACVPILKSFARPRKSRRQRILFYCHFPDQLLARRNEGGSLLRLAKLLYRYPFDWFEGWAMSASDRVVANSNFSRGVVHDVFGTDKLGDVQVLYPCVDTTTKTDIPVKEEDDVLWGGRKLLLSINRFERKKDMGLAIRAYNGLRPEKRAGTRLIIAGGYDNRVQENVQYHQELDDLAKGLGLKTATAKTVVSALSIPDEIDVLFLLSVPTAFKNTLLAQSKLLLYTPVNEHFGIVPVEAMFAGLPVLASNTGGPLETIVEGETGWLRDAQAVDEWTAVIEKVLYQMSENEREIMSQAGKARVQQHFSLAAMGGRLEEEISKMLSADRRTFRGWQQVLVVLVVLGSILAVLLAILLYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY28</accession>
    <name>A0A9X0BY28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PLAC8-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791122.1">
        <property type="nucleotide sequence ID" value="XM_056933581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BY28"/>
    <dbReference type="GeneID" id="81623830"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="40588" checksum="B7193BE4BF232A27" modified="2023-11-08" version="1">MDRPLYLDTQFGQGQEQGNGPRYSFINTPRDMQGSDDLHPSMFTAPHAQAVHDSAIVEPALRMQHHQPSTTFPLQHAQHNQYRDCKETPQSTQHGSPVQYKSPETSTGYSDEKAHLRPYVQCPPVEQHPAFHIPPNSPDRQSQLSPLPPKYPHDEAPSHGIQRRATFPVEPDANPLQSPQAIYFPPPATPAVPSSQEPPMNDLGAFHHPGQSMHPIQEAHGGSWNHELCECSNVGTCCLGITCPCILYGRTQHRLAMKSRKQDPTNMLGYNLLNGSCTGMALLCGCQWLLATVQHARTRKAYGIEGDICTDCVRATCCTCCTLIQDEKEIQTREERRERAARERGATLSSPYSAPTSMIYPGPPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYN8</accession>
    <name>A0A9X0BYN8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_004639</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791782.1">
        <property type="nucleotide sequence ID" value="XM_056934241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYN8"/>
    <dbReference type="GeneID" id="81624490"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF31">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14230)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5489749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="64945" checksum="B962B4DE12089DCD" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZI3</accession>
    <name>A0A9X0BZI3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">UDP-glucose:glycoprotein glucosyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_001323</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792957.1">
        <property type="nucleotide sequence ID" value="XM_056930926.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81621175"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000065">
        <property type="entry name" value="UDP-glucose:glycoprotein glucosyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040860804" evidence="10">
        <location>
            <begin position="27"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="11">
        <location>
            <begin position="43"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="12">
        <location>
            <begin position="278"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="13">
        <location>
            <begin position="414"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="14">
        <location>
            <begin position="685"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="15">
        <location>
            <begin position="1186"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1134"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1471"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5492577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1493" mass="167156" checksum="55CF56C36284048B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZR2</accession>
    <name>A0A9X0BZR2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_003024</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792586.1">
        <property type="nucleotide sequence ID" value="XM_056932627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZR2"/>
    <dbReference type="GeneID" id="81622876"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="35"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5491457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="126" mass="14629" checksum="D48DAC9315182A8F" modified="2023-11-08" version="1">MQKTDVAHGPLSAKDMKAIHMPCYLGCEYLNIDTCDLCLDDMAASSMFRQLPCGHIFHTPCVDLWLTTGDASCPLCRQTFYHLRNMKPSRMSVHHIERADQREHEHEHVSSENKFLRRIRRGLFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZV3</accession>
    <name>A0A9X0BZV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793302.1">
        <property type="nucleotide sequence ID" value="XM_056931271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZV3"/>
    <dbReference type="GeneID" id="81621520"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DUF3712"/>
    </dbReference>
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        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF1">
        <property type="entry name" value="LIPID-BINDING SERUM GLYCOPROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12505">
        <property type="entry name" value="DUF3712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5492922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="370" mass="40511" checksum="EFD5A34499CCAD3D" modified="2023-11-08" version="1">MVKADIEDGSSSDGHETAKESSERPSVWNRFGRHFKRWWWLYLVAFCCLFLIIFLPIIYVGIPHFANDYINNHEFSYEGLAITNPGPHSFQVTQFGSLNLGGGLTSSGHLTAFNASLRVPATEKEFAVFPFPRIEFGYESTLNIDHDVDISCVECFSDLAVAAVTNENFGLLVTGHPGLKLGAFPTAHLDIHKLIQMKGTEPPPMLLIGTICEHYETKLTLILSLGFNTTGFLSSNGNLNIIQLSLMSPAVNGFNVNATIAMRTAIGFTVEMGHVTFNLTLNGSKLGYLDVPNLKLEPDHTSAVVLGYIDESMLIREFIWGNGDGANVVIGFKGHGCDYNGVEIPYFAAAIKAIDASVTVNLLQYIGLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0C8</accession>
    <name>A0A9X0C0C8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793335.1">
        <property type="nucleotide sequence ID" value="XM_056931304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0C8"/>
    <dbReference type="GeneID" id="81621553"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
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            <begin position="82"/>
            <end position="109"/>
        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="299" mass="32960" checksum="369E89C449A74DF2" modified="2023-11-08" version="1">MFAAQPAPSTPTKPFRHTGHYTPVRPSPLGPHSTTTTATPPWTMGSPTPMRSGASPISFPTFTSAAGAVAQTEQPPRYHNPFSPSTGVSRSNSPSQTHSQSPSFTNIASSPAPLTHQPANAPTHPGQPNNKFAPQSPTPTSPTPSRQSRFAERYAAQIANPMRGTTSLARSKTRAMFLNRVRSERDTGRFEARGEQMMMAEHLADKRRWEESMAREADGALYGVERDIEDDGMLPVDEDELRALDEYLSQEEAFERAAQESISNAHRSRMTEPDVPFSDADYDDIFMQLQEHAQDMDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9X0C2H2_9EURO</name>
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        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
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    </dbReference>
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        <location>
            <begin position="103"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="214"/>
            <end position="256"/>
        </location>
    </feature>
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            <begin position="332"/>
            <end position="358"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
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        <location>
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            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
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            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5495069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="596" mass="64738" checksum="0C467FDACDB2F5B0" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2J8</accession>
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        </recommendedName>
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    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
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        </lineage>
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056929955.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81620204"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048800">
        <property type="entry name" value="Cac1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021644">
        <property type="entry name" value="CAF-1_p150_acidic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21796">
        <property type="entry name" value="Cac1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
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    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="153"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="9">
        <location>
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            <end position="483"/>
        </location>
    </feature>
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            <end position="656"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
    </feature>
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            <end position="20"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="244"/>
        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF21796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5495235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2S9</accession>
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        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_000500</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794397.1">
        <property type="nucleotide sequence ID" value="XM_056930104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2S9"/>
    <dbReference type="GeneID" id="81620353"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002123">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF22">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="248"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5495384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="886" mass="99523" checksum="4B057C7456820BB7" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C303</accession>
    <name>A0A9X0C303_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795014.1">
        <property type="nucleotide sequence ID" value="XM_056930721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C303"/>
    <dbReference type="GeneID" id="81620970"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18785">
        <property type="entry name" value="Inv-AAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5496001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="227" mass="25139" checksum="742549E6DB2AC04B" modified="2023-11-08" version="1">MTNQTPHSSYLRKCISLAEQSPPRPTNFRVGAILLSRKDEDPTGLEDRILSTGYTMELAGNTHAEQCCFSNFAAVHNVPEDEVAAVLPNEPGRKLIMYVTMEPCGKRLSGNAPCAQRIARTREGGRRGVHKVFFGVKEPETFVGESEGCRMLSAAGIEWEHIAGFEKEILTVAMAGHENSEAEVNAALGQGRQGTNVDDISPDERQRQEQMPRNSKKRMMEGETMIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKB4</accession>
    <name>A0A9W9WKB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_009502</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785592.1">
        <property type="nucleotide sequence ID" value="XM_056939097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKB4"/>
    <dbReference type="GeneID" id="81629347"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF668">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="56"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5466546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="465" mass="50774" checksum="0753F9D511DE778E" modified="2023-11-08" version="1">MSHQYTDQYADPVEDGQFRGRGDGMRKEEKAHLEQPNSEYEDPFGSEEFAEVKYRTLTWWQCGMIMIAETISLGILSLPQTVATIGMIGAVILIVGLGALATYTGYVIGQFKLRYPHVHSMADAGEVLFAPLGIPRFGREFLGTAQLLFLIFIMGSHILTFTVMMNTLTNHGTCSIVFGVVGLVVSFICALPRTLRKVSWFSFASFASILAAVFVTMIAIGIQRPGHGVVEATRHTSLANGFLATTNIVFAYAGHVAFFGFISEMRKPTEYPKTLYLLQGTDTTLYLVAAVVIYYYGGPDVKSPALGSTSSVTAKVAYGLAIPTIVIAGVINGHVAAKYIYVRAFRGSDHMHKRSFLSVGTWVLITLILWVIAWVIAEAIPVFSNLLGLIVALFASWFTYGLSGIFWLFLNWGNYTRSAGKIFLTCLNLFVFAVGAVLCGMGLWTSGVAIHNNASKSSFSCNANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKF0</accession>
    <name>A0A9W9WKF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_009531</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785621.1">
        <property type="nucleotide sequence ID" value="XM_056939126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKF0"/>
    <dbReference type="GeneID" id="81629376"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1760.10:FF:000002">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5466575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="188" mass="21198" checksum="FD3E0DB328117515" modified="2023-11-08" version="1">MPAYHSIFLEDRDVPVIGNFPILPLRTKTRGPAYTLPALPPNTPDMDVTPESESYDCIDEILSLFRANVLFRNFEINGPADRMLIYGTLFISECLGKVKPTMTARDAEKALINASLESFAIPGDVSFPLNQAFEPPRDRQDAETLRAYLSQVRQEIAMRLHARLYPGGEGPSKFWLSFTKRKFMGKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKQ1</accession>
    <name>A0A9W9WKQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-like GTP-binding protein RYL2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_008912</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785884.1">
        <property type="nucleotide sequence ID" value="XM_056938507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKQ1"/>
    <dbReference type="GeneID" id="81628757"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001584">
        <property type="entry name" value="Ras-like GTP-binding protein RYL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24073">
        <property type="entry name" value="DRAB5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5469294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="327" mass="34908" checksum="F658AD5BF5BCFC3A" modified="2023-11-08" version="1">MSSSLEAKIVVLGAQGVGKTSLVQRYVRNNFDPATTTSTVGASFVTKRVLDTTSDTIVRLQIWDTAGQERFRSISRLYYRGAHACLLCYDITDESSFQEMAGWLRELRRNIGGGAGDLDPLVIHVVGTKSDIVADDPAKRQVPFERTIAYVAEQLYPSRASTPPPTAGMSGISSGLGFAAGMFGSSGSGGGSTSAAGSLPTSSVLPLQSPDSKRSSAFWGQEIGWDCCHEISARDGEGIEEVFRVMTRKLVEQRNRRDAEAALSAVGTPGIDVPIGPFTPGLDRANGSFRLGHGDKRRSWLGLASPTVGDAEEVQVMDAAKQRGRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKY2</accession>
    <name>A0A9W9WKY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone h1.3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785999.1">
        <property type="nucleotide sequence ID" value="XM_056938622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKY2"/>
    <dbReference type="GeneID" id="81628872"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5469409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22018" checksum="E487424A2EE98E47" modified="2023-11-08" version="1">MSGSNDSDRMLGLSPSDERILLYGILCPSTDGSRNAIDYMKLASVLGYTPSSAKVMYGNARRKLARFTGMEVPIIARGNMARGTAAAGSKTTTDAPETDESPAKKPRKTSPTTSRKRKAEKLETTQTEGVAETHPQIATKTQAGTETQAETKIEAKAKSEVEAKAETDVEAGVHFVPEHKKENGEAEEEVVKTETGPSEAKEEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLC0</accession>
    <name>A0A9W9WLC0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome c oxidase copper chaperone Cox17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_009222</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786194.1">
        <property type="nucleotide sequence ID" value="XM_056938817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLC0"/>
    <dbReference type="GeneID" id="81629067"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome c oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR607745-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5469604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8234" checksum="B07F2EC81BE2E9A2" modified="2023-11-08" version="1">MSWLFGSSSGKAAAANPDTKSQASQGEKPKPCCVCKDEKAARDDCMLFSKSDDPAKECQTLIDQYKSCMLGYGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLC9</accession>
    <name>A0A9W9WLC9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit SPC34</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein SPC34</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">N7539_009189</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786161.1">
        <property type="nucleotide sequence ID" value="XM_056938784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLC9"/>
    <dbReference type="GeneID" id="81629034"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013966">
        <property type="entry name" value="Spc34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08657">
        <property type="entry name" value="DASH_Spc34"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ5469571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="246" mass="27468" checksum="C6938A7D949FB94A" modified="2023-11-08" version="1">MPLLESHLEQIALSSNAIAELPFPAPRIFTNALLGPHDITALIRDTEAHERALFQVDPDSKNHSAQRRATRRGTMFPAEPESESMASRIYSARNHRNQSAVARVLGHDMMEEIKRSAGTSTRGGRREVNIGVLLRGAEILCNVYPVSGAQEKIETLRYRHETISESIARLEDRVAANAAELERMRHSYGDDEPDVAPAEPSNPDISSVTDQDIERELSEIRELERRKRALEARVNGLDRDLGGLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLE2</accession>
    <name>A0A9W9WLE2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulatory protein SUAPRGA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786259.1">
        <property type="nucleotide sequence ID" value="XM_056938882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLE2"/>
    <dbReference type="GeneID" id="81629132"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5469669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31700" checksum="355CEE4413DB8278" modified="2023-11-08" version="1">MLSLRTFARAAPRISRSVARTSLPSTPLARPAINQSWKQTIKPAHAAFSTANIFREPAGEGDIELIAKLEEELKHEKASGQEDAREQQASIEYTLQSGEWQVKDVEGEQEVVLTKTFGNETIRVTFTVADINNLAEDPMDDLTDDALADEGDYQNKPAENEDEALPPTFPARVNVTIEKPNSGALLVQAVIQDGDLQIEEISHFKNADIANAQTAEKDWSRQSFYAGPPAENLDPELLAFWGRYLEERGLNLEFQNMVTDYIAFKEQKEYVSWLDNVRKFVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLH0</accession>
    <name>A0A9W9WLH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial zinc maintenance protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_008956</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with RIP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family. MZM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785928.1">
        <property type="nucleotide sequence ID" value="XM_056938551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLH0"/>
    <dbReference type="GeneID" id="81628801"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045298">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050435">
        <property type="entry name" value="MZM1/LYRM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749:SF1">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5469338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="114" mass="12873" checksum="5041EF2919455736" modified="2023-11-08" version="1">MSAPSATALSAYRQILRATRIAFRDDLRVMVAARQEARRNFDQNRRVGVDTGMHINHALEVANILRHNIVQGAREGNDESAKWQLRIHDEIERGDNDSIKVGNKDVKIHKACSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQS6</accession>
    <name>A0A9W9WQS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786474.1">
        <property type="nucleotide sequence ID" value="XM_056938092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQS6"/>
    <dbReference type="GeneID" id="81628342"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5471928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="185" mass="21275" checksum="8B5E742E77C86415" modified="2023-11-08" version="1">MLTLPLRGSSSPAVPYSSEFEVDLDDSMIDEDEHDTRRSKPEEVTVCLVLYSLQFALNLCLRQNHEEHKEVRPRVERRKATTRFTGMHEFVAEDDGGVCRMDWQSHGWMMGHPYLAILEAKRAFKYIHSDDRTGDCKPVVSNETLAQYLGEAVITWRANRDLLGQEEYTGSVFLIAATNTFLRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQX2</accession>
    <name>A0A9W9WQX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786597.1">
        <property type="nucleotide sequence ID" value="XM_056938215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQX2"/>
    <dbReference type="GeneID" id="81628465"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5472051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="71" mass="7531" checksum="11CC4D6B60A6F6DC" modified="2023-11-08" version="1">MVVGSISGALFVRSETPVVKLNIKDSLTLPHSADIELMALESFVSTTDMLTPAGTDVTLLVATTWELLPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU74</accession>
    <name>A0A9W9WU74_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_007898</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787364.1">
        <property type="nucleotide sequence ID" value="XM_056937499.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81627748"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
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    </dbReference>
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    <keyword evidence="4 14 16" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="15">
        <location>
            <begin position="265"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5475611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1447" mass="161705" checksum="680E9A3B546DF8A6" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUF2</accession>
    <name>A0A9W9WUF2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056937419.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81627668"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="116" mass="13180" checksum="7E0C6EB97205BC15" modified="2023-11-08" version="1">MTESSSVTGGRSPGSRETGRDTAKTESNRRRRGEERLPQKPQNDHRATLLQPHHATETELPYVTESPFKSAPAGSWWEESLLLVQQFFFLLSLRSSLPFDPVPVQLHPLPLIQFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUM7</accession>
    <name>A0A9W9WUM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787557.1">
        <property type="nucleotide sequence ID" value="XM_056936758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUM7"/>
    <dbReference type="GeneID" id="81627007"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="255" mass="28070" checksum="2A9F5A423D292ABC" modified="2023-11-08" version="1" fragment="single">APPPASVATSTPTSYETSRPSTTSTVATASSLSLPRACSTWVIEKLSEGAAPLALDQVQKGIGRPKTIPITGTEWLAPDTRSQQAYLDSYETLGELEAFKLVMRQGCISAPRLLGYIETEQGREEAVPGGFIKYLVPGESLTQELFWSLDCPTRDDIRARCRVALKEVLCCHVVPQMSAIPKMIYEQFTGNVYVKRRVLDMPERFTDNFQSNFGDSNGMANSDTFLNGQRLTMSHPDLLSPGTEISEVVDRLNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUR2</accession>
    <name>A0A9W9WUR2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongator complex protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_007734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787200.1">
        <property type="nucleotide sequence ID" value="XM_056937335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUR2"/>
    <dbReference type="GeneID" id="81627584"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19495">
        <property type="entry name" value="Elp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09807">
        <property type="entry name" value="ELP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5475447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="37052" checksum="C3C66A70C662E429" modified="2023-11-08" version="1">MPSQPPLPPLLTPYLSDLPESSLTVISSVLGATSNWLVLRYLHASLSNTANSNTSPENNGSIGRTSRKVVLVSFMRSWDFWKTEAKRLGLDLARLRDKRQFVFVDGLSELFTPSASAFSTVPVGSANHATLPLRNRPTPVPGRGPPAAGSLDRSAQDRRVQGDASNSVRLHFRGRGTAALDAIEKDIISELHRQRASSDENEELLLIIDQLDLLLAATGPGLGIGATEMADWVMGLQQHAHATVLTIAADSPLIHNAATNVHGDCTPIETEHAALALGLAHRARTVMQLRMLETGAARDVSGVLRISRGGGWNAEAKHSLDEKELLYYIQRDGGLRVFGRGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUU1</accession>
    <name>A0A9W9WUU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Haloacid dehalogenase, type II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787662.1">
        <property type="nucleotide sequence ID" value="XM_056936863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUU1"/>
    <dbReference type="GeneID" id="81627112"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019120">
        <property type="term" value="F:hydrolase activity, acting on acid halide bonds, in C-halide compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02588">
        <property type="entry name" value="HAD_L2-DEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01428">
        <property type="entry name" value="HAD_type_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5477118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26515" checksum="8F7F987B82B60EC4" modified="2023-11-08" version="1">MPSDKETVVAFDVYGTLLSTESIAGKLASHFGRTKAQEIAASWRKYQLEYTWRLNSMEYYEDFSQITRQSLHHALVEAQEQLTEGDISDLMKAYDNLSAFPDVKSTLQRIAADSSIVPVIFSNGSKEMISNSVSSSKDLSPHGTTFKHIVTVDDVQRFKPAQVTYQHLAAVVGKKPSEMDQIWLISGNPFDIVGARHAGLNAVWVDRAGYGWQDAAVPGLQPSAIVRNLEQIIDHIKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVA8</accession>
    <name>A0A9W9WVA8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_007517</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787917.1">
        <property type="nucleotide sequence ID" value="XM_056937118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVA8"/>
    <dbReference type="GeneID" id="81627367"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="443"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5477373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="796" mass="88366" checksum="761FEFCDFE433656" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVE6</accession>
    <name>A0A9W9WVE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <ecNumber evidence="3 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_007409</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3 7"/>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787809.1">
        <property type="nucleotide sequence ID" value="XM_056937010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVE6"/>
    <dbReference type="GeneID" id="81627259"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.960:FF:000005">
        <property type="entry name" value="6,7-dimethyl-8-ribityllumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
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    </dbReference>
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        <property type="entry name" value="Lumazine synthase"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <begin position="87"/>
            <end position="108"/>
        </location>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5477265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="204" mass="21424" checksum="4F53B8625A5E7586" modified="2023-11-08" version="1">MTSIKGPGAPETFDGSDLRIAIVHARWNTKIIESLVAGAKKSLFAAGVKEENITVQTVPGSYELPIGVQRLYAASQVQASQTGEGPSATDLLSGSTSDLSKTATSPATTPKKPFDAIIAIGVLIKGATMHFEYIADAVSHGLMRVQLDSGVPVIFGLLTVLTEEQGLERAGLGNGGMHNHGEDWGSAAVELGVKRRDWSEGKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2A4</accession>
    <name>A0A9W9X2A4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NIMA interactive protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">N7539_006957</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5481063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="81626807"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Afadin/alpha-actinin-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11559">
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        <property type="match status" value="1"/>
    </dbReference>
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            <end position="174"/>
        </location>
    </feature>
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        <location>
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            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00009291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5481063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="59954" checksum="C2F8D6449EE7132E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2M4</accession>
    <name>A0A9W9X2M4_9EURO</name>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">N7539_006916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
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            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788452.1">
        <property type="nucleotide sequence ID" value="XM_056936517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2M4"/>
    <dbReference type="GeneID" id="81626766"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5481022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="543" mass="59204" checksum="1000661CB6BC4821" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2Q6</accession>
    <name>A0A9W9X2Q6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_006207</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788733.1">
        <property type="nucleotide sequence ID" value="XM_056935809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2Q6"/>
    <dbReference type="GeneID" id="81626058"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00221">
        <property type="entry name" value="NRAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF101">
        <property type="entry name" value="MANGANESE TRANSPORTER SMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="548"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5482761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="577" mass="61821" checksum="01ABF2AC866A8558" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2Z2</accession>
    <name>A0A9W9X2Z2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NGG1 interacting factor Nif3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_006358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788884.1">
        <property type="nucleotide sequence ID" value="XM_056935960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2Z2"/>
    <dbReference type="GeneID" id="81626209"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000008">
        <property type="entry name" value="NGG1 interacting factor Nif3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5482912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="41589" checksum="096E6D2A514EB482" modified="2023-11-08" version="1">MASSSASTTSCSPFTQAVVGAMRKLYPEELADKSFDNTGLLLEAPFEPTRRQKNSVLLAIDLTTAVADEAIKRQDSAIVAYHPIIFRGLKSITLADTQQRSLLRLAQHGISVYSPHTAVDTVPNGMADWLCDVVTCNFSRCSSSPIDGLKPSIQTCSSSFYSAPTYPQPHAVPSTTNTESDISSSSPSSSSPPQQMPHSRSTIHPSPSASIPDGFEGAGAGRLVTFESAQPLTTLIDNIGRGVGLQPGIPIAIPQGQSVDSIQIRTVGMCPGSGSGVLLRGGQIPDLLFTGEMSHHETLAATERGSVVISLAHSNSERGYLRAVMQSKLKGELSRRWETERAAALKAMQESAKQGGAAPWTSAEDVYADETVDVAVSEADRDPYGIMIWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X4T9</accession>
    <name>A0A9W9X4T9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000007">
        <property type="protein sequence ID" value="KAJ5483841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789111.1">
        <property type="nucleotide sequence ID" value="XM_056935643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X4T9"/>
    <dbReference type="GeneID" id="81625892"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF7">
        <property type="entry name" value="DUF1275 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5483841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="26667" checksum="9CBCF16E131878B3" modified="2023-11-08" version="1">MGQQKKNLSGLSTFLKNEVDPRRADLLLFTCCLCSGLVDTYNTFVSMQTGNTIFVGLGASNQNPRPFGWARSLTSIGCFVIGCFLFARLNRIMGAQRRGSLMLSFFIQASLVIVTAALVQAGAVSSAIDDNSANPIVRWDQEVPIVLLSIQSAGQIVASRTLGYNEIPTVVITSLLCDLMSDPKLFLLRNEKRDRRIIAFVLTMVGAIVGGWVTKSTGNIAPILWLAAGIKYSVALAWGFWRVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5C6</accession>
    <name>A0A9W9X5C6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Paf1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_005799</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789273.1">
        <property type="nucleotide sequence ID" value="XM_056935401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5C6"/>
    <dbReference type="GeneID" id="81625650"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007133">
        <property type="entry name" value="RNA_pol_II-assoc_Paf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188:SF12">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03985">
        <property type="entry name" value="Paf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="439"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5484003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="53795" checksum="DDAB37C3183F01B7" modified="2023-11-08" version="1">MSSKSREDKSSGGFHQDYIASLRYRNDLPPPHMPPKLLDIPHDGLHRFITPEFAFNLARREEPNVDVDAEGGMPIDLVGVPGLHLGDESAIMAPEHPQPLDPADLPLLMTLEQLRNPAPRNTNVSFLRRTQHISVDRTTTPGGGVPGKPLKSRFVKKTKVSVEDPKHIKKFIMKGFDLAYPHTKHVGEDSESQVKGLSSTKAEFDAWERPVHPDNPRLKPVGVYPLMPDLSGYPDPGGFVQFKFDKAPVPAVGGKRDKRMDVALLHPSAPEERVCQEHASKQALHKSNPELHPDPGPVPFDYDLHLPEKMEHVKQLLASMDLKNPDRDNEDLYTHESAEGTKYHRFDRERTFATSAQVLNTDPKLRDIALTLYKAEEGDSKQQAAYYYPIISKVRLKLERARTIAQVGLAPAGSQLPEEKIDQLHITVRDPDEAENYKRSLHRANVDPKFARTLPPPPTQEVPQEHGDAEDDDTRMSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5D6</accession>
    <name>A0A9W9X5D6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Required for respiratory growth protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_005935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for respiratory activity and maintenance and expression of the mitochondrial genome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789409.1">
        <property type="nucleotide sequence ID" value="XM_056935537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5D6"/>
    <dbReference type="GeneID" id="81625786"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010487">
        <property type="entry name" value="NGRN/Rrg9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475:SF3">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06413">
        <property type="entry name" value="Neugrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5484139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="223" mass="25109" checksum="37AF5776AEF21258" modified="2023-11-08" version="1">MRELHLNGSPGTTMTSANPSATHESTPATSSSAPAELSASASASASTTPESQSTQSRWTKSQQPLRKGRTDNKQTKRDPERTNVKGRKTDKPKATPKTQEKAEPWRTQKDALEKKFPQGWNPPKRLSPDALEGIRHLHATAPEQFTTSVLAEEFKVSPEAIRRILKSRWRPSETEAEARRKRWEKRHERIWSRMAELGLRPTTKASRPYSDANTLYKSGERGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X618</accession>
    <name>A0A9W9X618_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alpha-1,2-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_004961</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789757.1">
        <property type="nucleotide sequence ID" value="XM_056934563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X618"/>
    <dbReference type="GeneID" id="81624812"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF5">
        <property type="entry name" value="(MNN2), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04450)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5484973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="56302" checksum="7FF2C67EEFCAA307" modified="2023-11-08" version="1">MAIPRQYLRLRTVLFAVVLTAGVVWFVSNWPSKIVIPHAFGHGSLEPFTGPATSQTLDLAKSQQRFWQQLHELVERHGPQAMPIVEYEKAPTEGFDPKDSHPLQNYLAVDLDDVSGIKIAHARFLAALTDDPLAFRVPYRPGTRGIVSTAGGAYLPVLVISLRMLRRTGSTLPMEVFLADEDEYEQEICDQVLPELNAQCVVLSQILTASPAKIEKYQFKPFAMLFSSFEEILFLDADAFPLQKPDQLLFDTEPFRTTGLVTWPDFWRLSVSPLFYEITGVEAPLRNLRQSTESGEVLLSKKTHGQTLLLVTYYNYWGPGYYYPLLSQGAAGEGDKETFVAAATVLRAPFYQVSERLVALGHRKSQEGGLAGSAMAQFNPVEDYQLHENGQSRLRGDEATQPGVFFIHANFPKFNPATIFDKHEVNPAFTDEGDYTRAWTIPEDVVGRYSENEDVEKAFWSEVKWTACELEDKFITWRDRPRGSICDGVVKYWQHVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6J5</accession>
    <name>A0A9W9X6J5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789850.1">
        <property type="nucleotide sequence ID" value="XM_056934656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6J5"/>
    <dbReference type="GeneID" id="81624905"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040882265" evidence="1">
        <location>
            <begin position="18"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="218" mass="24530" checksum="B06B87B2DCF03330" modified="2023-11-08" version="1">MHHALLSFLGLAPAILALPSVFPPVQVGQSVIPPDTLYYYRYNRIPLSLYGNELMTETFRHSEAMMSNMIKDFTCIANDKSICPSERWYCNSEKNKCMQKALIGETCRSDDACFSGYCRSRCSIRPGHFGAGCTDDNQCSSGLVCRRDSHHQNELRCLDRSDNGYGLAFICLDAWRQLEVPFFQTVTGALLNAPFLRESPSNMEGFGEACEVIWLVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6M1</accession>
    <name>A0A9W9X6M1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_005235</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790031.1">
        <property type="nucleotide sequence ID" value="XM_056934837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6M1"/>
    <dbReference type="GeneID" id="81625086"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="12">
        <location>
            <begin position="160"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5485247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="440" mass="50831" checksum="9C9F0069C746D90C" modified="2023-11-08" version="1">MTSTDGGSTRQRKARTSTHPTSSGPNSSETLKKEHIQSRVCSKKPRSFLRRLKRRAIKHTWSIPLLLLVAIASLYALDPTESNIVHHLIFLSYAQDPTDSDSISSLDNRPDHNNLPIQYGKGLWDIAFVAFYTIVLTFTREFIMQELLRPLARALGIKRAKQLRFMEQAYTAIYFGFSGPMGLYVMRRTPVWYFHTPGMYEGFPHRTHEAVFKFYYLFEAAYWAQQALVMILGMEARRKDFKELVAHHIVTLALIGLSYRFHFTYIGIAIYITHDISDFFLAISKSFHYIDSELVIPLYALNVATWIYLRHYVNLRILYSILTEFRTVGPYELDWETQQYKCWISNLITFALLALLQSLNLFWLYCLMRSAWRFVSTGEKKDDRSEEEGEEEVLVQEKLGSVNAREVSLVDAADVCIEVEEGCPTGVRDSEGTDRTGSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6V1</accession>
    <name>A0A9W9X6V1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">alkaline phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_005423</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790219.1">
        <property type="nucleotide sequence ID" value="XM_056935025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6V1"/>
    <dbReference type="GeneID" id="81625274"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF72">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040958081" description="alkaline phosphatase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="2">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5485435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="653" mass="72338" checksum="5B2D449470B3813F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6X8</accession>
    <name>A0A9W9X6X8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_005456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790252.1">
        <property type="nucleotide sequence ID" value="XM_056935058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6X8"/>
    <dbReference type="GeneID" id="81625307"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5485468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="76" mass="8472" checksum="9E85B3A9AA639E3D" modified="2023-11-08" version="1">MVLPPLNDDKLFLAVTTISDQFSMAYKQQGADGYLNHRNASVSRLGEVQIGEGEEIPSFVTIYIRRKVGLHGLFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6Y0</accession>
    <name>A0A9W9X6Y0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_004798</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789594.1">
        <property type="nucleotide sequence ID" value="XM_056934400.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81624649"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
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        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
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        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="10">
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            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="10">
        <location>
            <begin position="111"/>
            <end position="259"/>
        </location>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5484810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="272" mass="30002" checksum="6B6F36C15FCA66A1" modified="2023-11-08" version="1">MAARNPYVVPALTKHTATVIMAHGLGDSMSLAQNWRRRGKFNEIAFIFPNAPSIPITVNMGMSMPGWYDIAHLGRDVSLQFEIPCYSETIHDNDDNAHRRLTIASLLQLDFQKSARNQDEPGILRSREYFNSLIKQEMDKGIKPSRIVLGGFSQGGAMSVFTGVTGPEKLGGVFGLSCYLLLSDRIKNLIPENWPNKNTPFFLAHGEDDEVVNFAYGDQSAKLLKEIGLENVTFNKYSDLGHSADPNEIADLEKFLEKTLPAGGDEPASAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6Z8</accession>
    <name>A0A9W9X6Z8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor hoxa13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAPWDQ010000005">
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        </location>
    </feature>
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            <begin position="349"/>
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        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <end position="598"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="599"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5485498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1323" mass="142373" checksum="9C95AB6FD69B1AAB" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7K3</accession>
    <name>A0A9W9X7K3_9EURO</name>
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        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">N7539_005143</name>
    </gene>
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        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056934745.1"/>
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    </feature>
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            <end position="1021"/>
        </location>
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            <end position="75"/>
        </location>
    </feature>
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            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
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            <end position="122"/>
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            <begin position="139"/>
            <end position="148"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
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            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="987"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1021" mass="111337" checksum="BF6B316C23887491" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XC04</accession>
    <name>A0A9W9XC04_9EURO</name>
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        <recommendedName>
            <fullName evidence="5">DUF1446 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_003416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
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    <reference evidence="3" key="1">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sondergaard T.E."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790559.1">
        <property type="nucleotide sequence ID" value="XM_056933018.1"/>
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    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056362">
        <property type="entry name" value="AtuA-like_ferredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585:SF2">
        <property type="entry name" value="DUF1446 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11420)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23544">
        <property type="entry name" value="AtuA_ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="2">
        <location>
            <begin position="518"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5488526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="630" mass="69304" checksum="229881335046C47F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCD3</accession>
    <name>A0A9W9XCD3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790705.1">
        <property type="nucleotide sequence ID" value="XM_056933164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCD3"/>
    <dbReference type="GeneID" id="81623413"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="62" mass="6320" checksum="E1D3B7D8EFF7E0E8" modified="2023-11-08" version="1">MDETTAGPVGCVTSAAPPIAFADAQPPASRDGPGDTAQSSDLQGQLHPDDAPRRNCWLGSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCF9</accession>
    <name>A0A9W9XCF9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_003398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790541.1">
        <property type="nucleotide sequence ID" value="XM_056933000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCF9"/>
    <dbReference type="GeneID" id="81623249"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF66">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5488508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="316" mass="33073" checksum="0EE14AD416899555" modified="2023-11-08" version="1">MSSGLAARQRLQALSKQLVEGIPEEGSFEGIPKIRHIAGNSAGPRTQDKVVIVTGANSPNGIGRASAHQYANNGAKAVYICDYADSHLATHKREMESLYPGVDVHVRQFDAGDEKAVIAVVDDAISKYGRLDIFFANAGIVGQPKIFTEIDADGFMQTMKTNALGVFLAAKHAAPAMKVTSDSKPYPGGSIILTASVAGLRSNAGSTDYSASKAAVVSIAQTCAYQLTGTGIRVNAICPGLIETGMTQSVFDHARKRGTERKIGQLNPMQRGAVADEVARVALFLGSDESSYVNGQAWAVCGGLSAGHPVVPGKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCH2</accession>
    <name>A0A9W9XCH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790799.1">
        <property type="nucleotide sequence ID" value="XM_056933258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCH2"/>
    <dbReference type="GeneID" id="81623507"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027915">
        <property type="entry name" value="DUF4452"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39615">
        <property type="entry name" value="YALI0E17897P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39615:SF1">
        <property type="entry name" value="YALI0E17897P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14618">
        <property type="entry name" value="DUF4452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="159" mass="17279" checksum="75EE96CFC25C3A34" modified="2023-11-08" version="1">MSQQNAQRQFRGVKSMRELAEAPAVTAFRARFEAGRSFDLDDDMEFCPNLLTDEDLHSIHSASSDRSSLSSGSPDTSPLQHQIQPVQQVTPAISLSPASASAFVHGGMAANPGHVNYHQPAANRTRKVIPIVNPNTGMTMTSPPSSISPAMMHNAQRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCN0</accession>
    <name>A0A9W9XCN0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_003845</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790988.1">
        <property type="nucleotide sequence ID" value="XM_056933447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCN0"/>
    <dbReference type="GeneID" id="81623696"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20822">
        <property type="entry name" value="C1_ScPKC1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20823">
        <property type="entry name" value="C1_ScPKC1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08689">
        <property type="entry name" value="C2_fungal_Pkc1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11620">
        <property type="entry name" value="HR1_PKC-like_2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.160:FF:000004">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000191">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000014">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000034">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="C2 domain"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="237"/>
            <end position="355"/>
        </location>
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            <end position="514"/>
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            <end position="64"/>
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            <end position="79"/>
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        </source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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            <authorList>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
    </protein>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="TPR DOMAIN PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="TPR DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="575" mass="64988" checksum="23E3E542DDD850C3" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCY8</accession>
    <name>A0A9W9XCY8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosducin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_003892</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791035.1">
        <property type="nucleotide sequence ID" value="XM_056933494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCY8"/>
    <dbReference type="GeneID" id="81623743"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02987">
        <property type="entry name" value="Phd_like_Phd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001200">
        <property type="entry name" value="Phosducin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="139"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5489002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="286" mass="31980" checksum="BCA29E021B120692" modified="2023-11-08" version="1">MSAQEEFDQLVQNNRAQHSSHPEDRAESPHFSDDNDSLSSPPRQIRQRRLIDSSDEDEDLSSNMVSSRSNYHVPNTVFEANTGPKGVIADAQAFERAKKKSFRRTLLSAAGFDPNGSAFGLNKASRNDSSSAPEGSSESDGDEEQFMNKWRASRMQELQNRNTRRQSPRGRRFGSVETVDAAGYLDAVEQVTPDTVVVVCIYDPYSDQSAIVEECLVTIARRQTSTRFVKLHHEIAEMNHIRAPALLAYRGGDVFTTITDIIHNIPRGRSCSADSLEDLLKLHRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDN1</accession>
    <name>A0A9W9XDN1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inclusion body clearance protein IML2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Inclusion body clearance protein iml2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_004191</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as a chaperone in inclusion clearing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with lipid droplet proteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791334.1">
        <property type="nucleotide sequence ID" value="XM_056933793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDN1"/>
    <dbReference type="GeneID" id="81624042"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5489301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="709" mass="78925" checksum="D6AB130E718C3EE9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDQ0</accession>
    <name>A0A9W9XDQ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_004379</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791522.1">
        <property type="nucleotide sequence ID" value="XM_056933981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDQ0"/>
    <dbReference type="GeneID" id="81624230"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="79"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5489489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="121" mass="13194" checksum="2A09FA99A31F3B58" modified="2023-11-08" version="1">MSAIGSLIFCTDCGNLLRESTGDENAILHCTVCGARNKDIIPQTIVSESKPSAFPSALRSKRSAVQTLSAEDRKTEAVTNHTCNQCGRTEMFFTTVQLRSADEGSTVFYRCVCGYKETSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDY0</accession>
    <name>A0A9W9XDY0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Intermediate filament protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_004505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056934107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDY0"/>
    <dbReference type="GeneID" id="81624356"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
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        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="6">
        <location>
            <begin position="100"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="416"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="873"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="557"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="685"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="773"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="558"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="633"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="703"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="773"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5489615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1249" mass="139498" checksum="7C700701E26A04EC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDZ4</accession>
    <name>A0A9W9XDZ4_9EURO</name>
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        <recommendedName>
            <fullName evidence="4">Hypervirulence associated protein TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="81624268"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        <location>
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        </location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="36727" checksum="92756C0637034839" modified="2023-11-08" version="1">MPSRDKYTDPELRDQVKEEIHNSDKGGEPGQWSARKAQMMAAEYKKRGGGYTTDKETGQDSSQKNLDKWGEEEWQTKEGPGQAKQEDEEEAGTTRKRYLPKKAWEQMSEKEKEETDEKKVEGSRQGKQFVGNTEEAKGARKGVSDGQRGKGGDEKDGKDDGEGDEEEEVEQGEGEDEDENEQAKTQDKGQGKNKGGKQQQQKQEEKKKNDDSNKTTPPKTRSASKAEAKDENEDENDGEESKGEEKAEAGTKRTAEQSTGSNKRQKENGQSDKSKKPAAKDDNENNKKEDKQQKGGDDQAQAEDGNEEEYVPEGEADGDEDMEDDEAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE15</accession>
    <name>A0A9W9XE15_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">N7539_004559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
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                <person name="Frisvad J.C."/>
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            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791702.1">
        <property type="nucleotide sequence ID" value="XM_056934161.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81624410"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5489669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="285" mass="33114" checksum="0587D5C202D9464C" modified="2023-11-08" version="1">MWSDKQTSGFTPVKGYSQTHLVDRKLLYGPDSTPCSAFVLGQIIWFDYALRYLSQIEAALVKKRKKCLQRRDLDPALLKSCDDLLAETREEFADLEQGMLVTENMLPEGNVKGAYETLREDPSWWLRKELVRECIARGGCCARRCGCCENRSLDRSKGHGLGHCTSACHCCAKTGEWWVTTERRAEMIDILGDSLHSRDPEYLVKMADAFFEPQKKSALAKLSERLVRKVKTGIAEWREKRLERMHLKQIEKLHRVEIERVRLLEVKELLAYNACYFDEKDWECW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE41</accession>
    <name>A0A9W9XE41_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_004446</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="81624297"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="Cgr1-like"/>
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        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
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            <begin position="1"/>
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            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
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            <end position="103"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="9">
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5489556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="118" mass="13844" checksum="BEB5D4B842517FC8" modified="2023-11-08" version="1">MSATAETPATTPATVPAVGMRKNGKNWHSTKKAFRPTAGLTSYAKRQETRKQLEANKEREREMKEEKEAERQAHIQRIKDKRAAKEEKARFEKMAEKMHAKRVERLRRREKRNKLLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE57</accession>
    <name>A0A9W9XE57_9EURO</name>
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        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">N7539_003972</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
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            <authorList>
                <person name="Petersen C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR23502:SF139">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="69"/>
            <end position="86"/>
        </location>
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            <end position="183"/>
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            <end position="216"/>
        </location>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="388"/>
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            <end position="494"/>
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        <location>
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            <end position="522"/>
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            <end position="526"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5489082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="552" mass="61319" checksum="1814A015F2B54EB5" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XES8</accession>
    <name>A0A9W9XES8_9EURO</name>
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        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">N7539_002502</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792064.1">
        <property type="nucleotide sequence ID" value="XM_056932105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XES8"/>
    <dbReference type="GeneID" id="81622354"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF19">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="46"/>
            <end position="249"/>
        </location>
    </feature>
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            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="484"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5490935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="542" mass="60176" checksum="62C753A7FDB3552E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEY1</accession>
    <name>A0A9W9XEY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein stu1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_002582</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792144.1">
        <property type="nucleotide sequence ID" value="XM_056932185.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81622434"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060172">
        <property type="term" value="P:astral microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="319"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="265"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="549"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="830"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="556"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="599"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="676"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="707"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="753"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="865"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5491015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1283" mass="141112" checksum="A2F76655B158B7A2" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF03</accession>
    <name>A0A9W9XF03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cation efflux protein cytoplasmic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_002536</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792098.1">
        <property type="nucleotide sequence ID" value="XM_056932139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF03"/>
    <dbReference type="GeneID" id="81622388"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF12">
        <property type="entry name" value="CATION DIFFUSION FACILITATOR 1 (AFU_ORTHOLOGUE AFUA_1G14440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
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            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="9">
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            <end position="444"/>
        </location>
    </feature>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5490969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="51318" checksum="061C5FD8FC9A3659" modified="2023-11-08" version="1">MEEHIRNSISNHPHPFQHMTVGSPHPSHRSERLASCAYDEGTSTGVEAEDPKMAQQQHRHVSADEEGMPPPRYDSETDPFQLASKLKTDEEIRQIKANIGRKRDRDGTRMMELVRETGAKGKNALVARKLQGFYEEQNENIERLLRPVEEHVRAARELNSENSVKYKIAVYGSFAANIILCVVQVYGAASSGSLSLFTTMADAIFDPMSNLTLLLCNKAVNRVDPRKFPAGKARIETAGNICFCFLMTAVSFIIIAFSIREIVAGSDTLTSSFHLPSIIAVAVAFVTKLALFIFCFALRDQVSQIRILWEDHRNDLLINGSGLATSLLGSKVRWWIDPMGAILLSVLVSGLWLHSAYGEFQLLVGVTADTKMQQLITYISMTHSPFITAIDTVRAYTSGPRLVVEVDIVMDDSASLRTTHDVAEELQMKLESLPDVERAYVHVDYETTHKPEHFLKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF93</accession>
    <name>A0A9W9XF93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_002733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792295.1">
        <property type="nucleotide sequence ID" value="XM_056932336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF93"/>
    <dbReference type="GeneID" id="81622585"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046366">
        <property type="entry name" value="MPAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124:SF6">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5491166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="49097" checksum="B83ED892DBF4461E" modified="2023-11-08" version="1">MDKATSIVTSVWQSQAVQAVLDAGPRHWLPYAVALAMGYPILTRSLRYRRLKALHSKFPYRTREDMARMTDDDAFEIQKAIAQLEFPMIFIKALQFALFRTYGIPTISHLLVQTSQFSNPETSLKRYTDTSTLVAEMVGNRPTSHRAYASLARTRFLHSGYRASGKILDDDMLYTLALFALQPIRFIDRFEWRQLSDLERCAIGTFWKSAGDALDVSYAKLPSGATGFKDGIQWLEELEVWSEAYEAEKMVPDVKNRETADQTTAILLYILPKPLHSIGLQAVSYMMDDRLRKAMLYDPPSPFVSTAISSILFLRKWVLRHLCLPRPYALRKAPFTENLDENGRVFVTQWDAAPYYVKPTFWNRWGPTALFTRVLGLPVPGDEGDKYYPEGYQIEDVGPTYFEGKGHKTLQKTMEEYKGYRTGKCPFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFA9</accession>
    <name>A0A9W9XFA9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein SDA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_002623</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792185.1">
        <property type="nucleotide sequence ID" value="XM_056932226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFA9"/>
    <dbReference type="GeneID" id="81622475"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="57"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5491056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="209" mass="23076" checksum="DD491DA125BDD542" modified="2023-11-08" version="1">MSDSGDVQAVQLPKEIAHLDNQPVLLFGKWSYEDVEIRDISLTDYIQIRQPVYTSHSAGRYAAKRFRKAQCPIIERLTNSIMMNGRNNGKKAMAVRIVAHAFEIINITTDSNPIQIAVDAIVNCGAREDSTRIGSAGTVRRQAVDVSPLRRVNTAISLITIGARESSFRSVKSISECLAEELVNAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFE7</accession>
    <name>A0A9W9XFE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792323.1">
        <property type="nucleotide sequence ID" value="XM_056932364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFE7"/>
    <dbReference type="GeneID" id="81622613"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF2">
        <property type="entry name" value="HYPOTHETICAL POLYSACCHARIDE DEACETYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="321"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="598" mass="65515" checksum="5B1E88AB8872B1A4" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFF9</accession>
    <name>A0A9W9XFF9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791892.1">
        <property type="nucleotide sequence ID" value="XM_056931933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFF9"/>
    <dbReference type="GeneID" id="81622182"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF9">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5490763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="414" mass="46914" checksum="6C4A4DC7A2807FB0" modified="2023-11-08" version="1">MLGWTAQIRRRIGPRRGLVLCTLLIALAVLVRGLSLLQNDLNTRQAAALAHDRPRYLYRSFFRNDPDLVLEEQVSHALEEIEHQQPAQHGDKESAHTIWQIMLGSQDNGSPTRGDDSLKFEEVNSEWKYKLVTTEWAEEFVTITLASIPGLARLYHSYPHHVLRADLLRYLILWYYGGYYADTDVFPAKSINNCPSLQQSVFQTDTPDVSLVVGIEIDEPFASAQKMHDWHWVRSYGFIQYTLYAPRRFSPLLRQIIVRVLSHTKRHIDSGSFFLGARYNELTTLEITGPGVFTDTILDVLSNTLPEDHPLILQSLEADEGLGDLIPPSSEIPQKRVTWAPFHRITSPVCVNGSEAKSGSDLGGLCVLPVNAWGNGQRHSGAENFLSAHACINHRFGGTWKPWKKSWKKYIFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFR2</accession>
    <name>A0A9W9XFR2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein bli-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792057.1">
        <property type="nucleotide sequence ID" value="XM_056932098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFR2"/>
    <dbReference type="GeneID" id="81622347"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052917">
        <property type="entry name" value="Stress-Dev_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="2">
        <location>
            <begin position="33"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5490928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="212" mass="22867" checksum="F5C2389572BB08CD" modified="2023-11-08" version="1">MSTENATINTSTGKHPVDPYKAQNAEDPPLPQKVEELVEFINQVKFGMLTTKQSDGEYLTSRCMALAATEHGGIDLVFHTNLFSGKTMDLTVHPQETNMSFLDPVSGSWASISGTASIVSDPATVSKYYSPQLKAWIGDMGDGVHDGGPTDPRIGVIKLEAKLATHVASKKGILGRAMDTVKGAIKGDVPAINSIRELSSEELAEWRKSHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFT0</accession>
    <name>A0A9W9XFT0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_003032</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792594.1">
        <property type="nucleotide sequence ID" value="XM_056932635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFT0"/>
    <dbReference type="GeneID" id="81622884"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000011">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF24">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="7">
        <location>
            <begin position="69"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="8">
        <location>
            <begin position="262"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5491465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="545" mass="60065" checksum="D1B9D691CE952A54" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG18</accession>
    <name>A0A9W9XG18_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_002835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792397.1">
        <property type="nucleotide sequence ID" value="XM_056932438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG18"/>
    <dbReference type="GeneID" id="81622687"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="493"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="682"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="694"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5491268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="706" mass="77866" checksum="3FF9EE8A8702F5CE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG43</accession>
    <name>A0A9W9XG43_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_002554</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792116.1">
        <property type="nucleotide sequence ID" value="XM_056932157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG43"/>
    <dbReference type="GeneID" id="81622406"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF5">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5490987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="147" mass="17303" checksum="2A962DB8C9FC0F48" modified="2023-11-08" version="1">MASSSDSADTTTTIPITKKYNFRNPLPLSASQEQEVKQLYHKRVRARCAPEIKAFAECAVNRTVTATWVCRQQRLAMNACMLTHANNPEEEDRAREEWFATYEERRRAKEEELKRVEKRRAEVITMMRQDEERRRQEKQQQQQGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGE5</accession>
    <name>A0A9W9XGE5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB/POZ protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001268</name>
        <name evidence="1" type="ORF">N7539_006551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792903.1">
        <property type="nucleotide sequence ID" value="XM_056930872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGE5"/>
    <dbReference type="GeneID" id="81621121"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5480657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="72" mass="8369" checksum="4D92A9AB0C229212" modified="2023-11-08" version="1" fragment="single">INIKDDTLETIERILSFLYLRDYNKDSLSLLENKLEILELANRVTFNNIKVFIATNKYIILPLKALATLKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHA1</accession>
    <name>A0A9W9XHA1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_001346</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential for proper morphogenesis of the vacuole. May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792980.1">
        <property type="nucleotide sequence ID" value="XM_056930949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHA1"/>
    <dbReference type="GeneID" id="81621198"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097576">
        <property type="term" value="P:vacuole fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06897">
        <property type="entry name" value="PX_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15858">
        <property type="entry name" value="SNARE_VAM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000058">
        <property type="entry name" value="VAM7p Vacuolar SNARE protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="7">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="316"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5492600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="379" mass="42549" checksum="9CFE79CFC6C1BB4E" modified="2023-11-08" version="1">MAPTVEISIPSTTVSHTSTPHTLYHITLRLPLRSFTVSKRYSDFVAFHSDLISQTNAQPPLPLPSKSWFSNTVSNERFREERRRGLEQYLRAINEATDGRWRTSSAWRAFLNLPSVATASSSNGTTITSSRLHAAITDPSSAANASINDPTLWLDYYRDMKTHLHDARLQLSRRDQETTPQKQHESSAQAKSSLVRAGSMISTLEEGLKNLGMRGNQDPSRSTSSLGDGELRRRKDLLINARKERDGLEDLLHAMAAKSRLDNAVASIEDKEALLKASNMDAAGGRRNATRSGRVLGKETERTRELDNEGVLQLQQQTMRDQDQDVQELLKIIIRQRELGNAIHEELEVQNEMLELADEDTDRLNAKLDIAKKRIGKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHN2</accession>
    <name>A0A9W9XHN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793444.1">
        <property type="nucleotide sequence ID" value="XM_056931413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHN2"/>
    <dbReference type="GeneID" id="81621662"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040862607" evidence="2">
        <location>
            <begin position="19"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5493064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="352" mass="33081" checksum="C8DBEE098349C686" modified="2023-11-08" version="1">MKFTGVAVSLALTGMASAAALPPMIPGTGSLTGSLYSLGSGAGGLQGASAAEGVLGGIGKREPGTAGLPGAESLIGGLGGLGGAGGGLQGANGLIGGLGRPSTGGLNDRASDTSDVVGEASNKSRGEKGQGAIGGTPIPGLPKRQLAAAQPVTNGAGSSLNGATGTAGSAVGTGESTGQGAAGTAEQMVANAGHLKPRSDVLGLLGTKSLGGAGDVIGGLTKGFTGGSGITERQLDAMSPVTEAVGSSMNGVTGTGGSAVGTAESTGASVVGTAESSVSGSGRVVKRQFGNLPATTSQTGSDLMAGVSGNPSGMYGALNNLRTVINAGQITPSDISNMPEAVQRVIANLAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHW1</accession>
    <name>A0A9W9XHW1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793656.1">
        <property type="nucleotide sequence ID" value="XM_056931625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHW1"/>
    <dbReference type="GeneID" id="81621874"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="213" mass="24319" checksum="A5EA83B75A693195" modified="2023-11-08" version="1">MTKDGMKSDSGGNHENEVADLTPRRNNIRLTAPDLAQESRDVGERETRIPLEKKWEEWCKINMFIASLGISDGSKKRSRRSSSAFAGKREKVVLKAAVVFGRFMVNKAQDRGNNNKIGQTSMIEEKRLATDAHGLGLRHCNSSVEAYAVMPSTEVHIRMLVVYDEENKARNRIDKKEEPDNPDATILYRIHQGEESEAKRHKTMRWKEEQPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIL8</accession>
    <name>A0A9W9XIL8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793670.1">
        <property type="nucleotide sequence ID" value="XM_056931639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIL8"/>
    <dbReference type="GeneID" id="81621888"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF1">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040728259" evidence="2">
        <location>
            <begin position="20"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5493290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="479" mass="54355" checksum="B79E47D13DE929D4" modified="2023-11-08" version="1">MKSIVTLAALSGLMAATSALPADHNSRTWEKLRNNPTDTAEFPVQIKHVVYLTLENHSFDNIAGYWDFNPHIDNLRKIDYCNQYTNPNWTVWGEPLEICAGPFETEVPLVDPDHDFAGVTYQIFRKWNITNDDAPNMAGFVERQSEKYKSTPGDAAFVIKAYDQKKTAVLAQLAQNFAFFDAYFAEHPGPTNPNRQFATSGSTCGFVDNTDQSAGFWNNVTGTTCATSIFESLSKKNVSWKNYYETDIVDAFMYKWVQDNAMDHLAHADEFYRDLEQGTLPTFSYINPECCTVDSMHPTSSMAPGEQMVKHLYDAIRRSKYWDNVLLIINFDEHGGFADHVPTPINVPQPDDKISFTGKSEGRAVTYDFTRLGVRVPAFLISPFISANTLIHHDGTSYADDSAYTHSSILHFLQELWGLEGLNNRVQWAKTFEHVFKDHKRDDAPEKLLTPSWEGGSNQPEPKPFYKLNQDYSYYASLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XKZ0</accession>
    <name>A0A9W9XKZ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_000010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793907.1">
        <property type="nucleotide sequence ID" value="XM_056929614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XKZ0"/>
    <dbReference type="GeneID" id="81619863"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901991">
        <property type="term" value="P:negative regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="594"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="634"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="649"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5494894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="659" mass="74749" checksum="3BC0A496E56222B0" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLF8</accession>
    <name>A0A9W9XLF8_9EURO</name>
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        <recommendedName>
            <fullName evidence="2">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1310"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="1005"/>
            <end position="1323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1333" mass="150189" checksum="28A2B55593276B38" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLR8</accession>
    <name>A0A9W9XLR8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_000478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794375.1">
        <property type="nucleotide sequence ID" value="XM_056930082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLR8"/>
    <dbReference type="GeneID" id="81620331"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5495362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="130" mass="14208" checksum="3F8E78ABE41918B9" modified="2023-11-08" version="1">MLPIESEASGNTSGPWWSVPSLRCFEGALSISENMNLGSKNVAQYKIIHVRVQTIQDPLPFINSGYRIFIDFQSRLQYMSTGRLTYSITSSVFWKRTRIALEGARIRLRGVITPSTAGAGAGTSAGAIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLV0</accession>
    <name>A0A9W9XLV0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosylceramide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">UDP-glucose ceramide glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">UDP-glucose:N-acylsphingosine D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_000071</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793968.1">
        <property type="nucleotide sequence ID" value="XM_056929675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLV0"/>
    <dbReference type="GeneID" id="81619924"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="501"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5494955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="538" mass="60443" checksum="E3F06838CF5DBD9D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMB6</accession>
    <name>A0A9W9XMB6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1279 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794646.1">
        <property type="nucleotide sequence ID" value="XM_056930353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMB6"/>
    <dbReference type="GeneID" id="81620602"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF0">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1279" evidence="2">
        <location>
            <begin position="111"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="251" mass="27899" checksum="7AC5071B24C0DDC1" modified="2023-11-08" version="1">MSRASPALLSRWLAQPTELLFPRLLRSQQRQLPSRRFLTLQSRSSQARKPKTVLNDRSATSSSSSSSLASSTSRFCRAQRRFNSTKSSTPGPSSSQAQSQAQKQAPQGLSQRLRTLSREYGWAALGVYLGLSALDFPVCFVAVQLLGVDRIGHWEHVIVSSVKNAVHSMWPSTWSQSRKGEAHDGKRDEEGGEESESQNKASIWTQLALAYAVHKSLIFIRVPLTAAATPKIVKVLRRWGWDIGKRKPKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ16</accession>
    <name>A0A9X0BJ16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Efflux pump roqT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_009374</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785691.1">
        <property type="nucleotide sequence ID" value="XM_056938969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJ16"/>
    <dbReference type="GeneID" id="81629219"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="511"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="54"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5466645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="555" mass="59938" checksum="6F7BE98DAC057767" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ54</accession>
    <name>A0A9X0BJ54_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_008854</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785826.1">
        <property type="nucleotide sequence ID" value="XM_056938449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJ54"/>
    <dbReference type="GeneID" id="81628699"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
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            <begin position="17"/>
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        </location>
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    </feature>
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            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5469236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="687" mass="77625" checksum="10AB7F0C2EAD3FB6" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9X0BJA8_9EURO</name>
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            <strain evidence="2">IBT 30728</strain>
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    </reference>
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            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        <source>
            <strain evidence="2">IBT 30728</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="709" mass="76967" checksum="1E3FDDD192DD251F" modified="2023-11-08" version="1"> </sequence>
</entry>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="157" mass="17782" checksum="53001014775117A4" modified="2023-11-08" version="1">MSTTKKSSDQGNVKACGANTQGLHIQRTLFTVSRPVTSPSSAPPRHRVHQLDVNLRFQIVALKVVGKWSYGQIHKKYPDIPLSTIRYTCLESRIRNKEQSSNRARRLKVLNYNARQNVLPKIYEDPQVSHDDFLASVSQKCKANSIARLLSVEGLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BMX8</accession>
    <name>A0A9X0BMX8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">N7539_008070</name>
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    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <proteinExistence type="predicted"/>
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            <end position="80"/>
        </location>
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        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5475004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="33008" checksum="B1B8C2E26C1CE393" modified="2023-11-08" version="1">MTTFVKSPISAILASTIPTQSSYSVFIAILTPTNEVTNSVGDATSLLVIGAYESEHVPTISMHNSTGRPATKPSVLSSRPSAIEGPATIPTSLAATGVEKTSSVPPVTTSGSRNMMLHISATNITTTSGFTSTDSLSLDIATPTSKTAHVSTVLDSVPIAHTTIASDTASSFPAATASTVSPMLSGKYTTITVSKFIVSTSQSPANPSTSTGNSKDDDHPDGTGGLGNTDGSANTAGANGSSAGIGVGVVVGAIAYGAGMFWIARHYRRRRRLRRHGILTSGEGNFGTAIKPPNSEIGRSTRPLYPRQKISAPLESGNSLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNL7</accession>
    <name>A0A9X0BNL7_9EURO</name>
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            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <lineage>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787549.1">
        <property type="nucleotide sequence ID" value="XM_056936750.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81626999"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF3">
        <property type="entry name" value="AMINO-ACID PERMEASE PB1C11.02-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="60"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5477005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="543" mass="59398" checksum="CE422F5053F6FFF0" modified="2023-11-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNM2</accession>
    <name>A0A9X0BNM2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_007208</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787608.1">
        <property type="nucleotide sequence ID" value="XM_056936809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNM2"/>
    <dbReference type="GeneID" id="81627058"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034737">
        <property type="term" value="F:ergosterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008204">
        <property type="term" value="P:ergosterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF9">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="241"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5477064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="537" mass="61847" checksum="E0E04AF2560E87B9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNN2</accession>
    <name>A0A9X0BNN2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_007830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787296.1">
        <property type="nucleotide sequence ID" value="XM_056937431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNN2"/>
    <dbReference type="GeneID" id="81627680"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019716">
        <property type="entry name" value="Ribosomal_mL53"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10780">
        <property type="entry name" value="MRP_L53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5475543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="106" mass="11548" checksum="A0D8B5C203178F88" modified="2023-11-08" version="1">MSIPIHTITTFRTTFNPFSQASRPCRLVLSLLRTPASASPASPQHIDIKVKQLPRGSTEQPSMTVGFKGGKEVTLEVGKRGMKIGDVVEEISRIGRAMEREASLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNV0</accession>
    <name>A0A9X0BNV0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI anchored cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787848.1">
        <property type="nucleotide sequence ID" value="XM_056937049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNV0"/>
    <dbReference type="GeneID" id="81627298"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640:SF1">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040819951" description="GPI anchored cell wall protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="20564" checksum="893E808CE348F423" modified="2023-11-08" version="1">MSGISLFLLSILGSLAVAAAAPSSTVVSYLVADDILDTWVAASVIAVNPKATTYEVKCVPSASASDCSLDPPITLIAGPTTVNIQIPLSESTRVGGIDLERRGLMTMACSFTHSIESITCTATEAMTAIARGVTKTSTGSQSGSILPTDASYKALTVTGGLEKFQASATSAPTSATTSNPADRVMVTGMPFGAAVAVAAAAAWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BP57</accession>
    <name>A0A9X0BP57_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788002.1">
        <property type="nucleotide sequence ID" value="XM_056937203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BP57"/>
    <dbReference type="GeneID" id="81627452"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF6">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="155" mass="17773" checksum="EB93E8175C1E3382" modified="2023-11-08" version="1">MATAEKTKEKQKQFQVPEYDSEEDYDSADDVEYSDEEEDVAPKKKQQLQRRRLQPQEADDYSDDDQYDSEEFDDEEDYSDDNDDDDEIVQGKSMQPWSQGSSGEKPSGGMNMAPQEKTGDAFADQDGMKLKLELNLEIEIELKARIHGDLTIALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSH1</accession>
    <name>A0A9X0BSH1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788514.1">
        <property type="nucleotide sequence ID" value="XM_056936579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSH1"/>
    <dbReference type="GeneID" id="81626828"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5481084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="107" mass="11695" checksum="F074012E4B3B6B1F" modified="2023-11-08" version="1">MQLASKNQVAKYSSTVLALEHSPTSHYRPSYNQPPANEPVAGEGGSIFLVCIEYRLLIGPGGPPFHCQMPTVELVSRALLPYDLKSTSLPMTAQTVLCLRLPEDVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSW9</accession>
    <name>A0A9X0BSW9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789010.1">
        <property type="nucleotide sequence ID" value="XM_056936086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSW9"/>
    <dbReference type="GeneID" id="81626335"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5483038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="249" mass="27945" checksum="C994DB2EFD163D9A" modified="2023-11-08" version="1">MNAWTGHQGPVHVYDGIDSGLNLPVSLESKQTLIIAVSPRGPRNSNNPNIHAVRTPSTVIDSMLDKRRDRTVKPPGDEKILGEFNLTDWTLAAEHWDAPTDLHDVEMIARNSRILNLDRRPRESRRSGILQYLAQIPPYPSSLYRRFINPAPACNPDLHQGSQASIFRLPRGSREYRPTSRDWPERRPRDRPNDHSGIRDHGQNPHLLAAGQLLPDISENVLAEKVSITPYVNVQLSPSGGLGYRLGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BT73</accession>
    <name>A0A9X0BT73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="2 7">2.4.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Asparagine-linked glycosylation protein 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ALG13</name>
        <name evidence="9" type="ORF">N7539_006290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 7">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UDP-N-acetyl-alpha-D-glucosamine = an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23380"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.4.1.141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1 7">Heterodimer with ALG14 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="2 7"/>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BT73"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052474">
        <property type="entry name" value="UDP-GlcNAc_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47043">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47043:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5482844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="189" mass="20837" checksum="86BDB5E085783CA9" modified="2023-11-08" version="1">MAVKLCFVTVGATASFEGLIRAVLQDSFVAELERHGFTRLLIQHGKGGQELFDAYRAEYENGQKRHGLEVGGFDLCPDMTPYVSMVRKDEANFQELGMMISHAGTGSILDALRASVPLVIVPNPDLADNHQQELAEELAGQGYAIVGKLDDLPSVVAKATNYGERAPYFRRENEKPFAVMSDELSWTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BT88</accession>
    <name>A0A9X0BT88_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mtf2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788861.1">
        <property type="nucleotide sequence ID" value="XM_056935937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BT88"/>
    <dbReference type="GeneID" id="81626186"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043837">
        <property type="entry name" value="Mtf2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040009">
        <property type="entry name" value="Mtf2/C5D6.12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468:SF1">
        <property type="entry name" value="MTF2-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19189">
        <property type="entry name" value="Mtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mtf2-like C-terminal" evidence="2">
        <location>
            <begin position="267"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5482889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="497" mass="55401" checksum="E327BFFFE70AE8FA" modified="2023-11-08" version="1">MATHISRAFYLSATTSSPTPFLYQTRTLAPISLSLRRTFAARVRQYSAENRASYEYGRRGGSPRYDEEGSAYESSPHQSGSESRASSAQPRRSYLRRRSASVTSKGRSQGRSPSLHSTKSSTTVTGPERKAFGELLGQLGVGRDQVADTGDSKQSQNVPQEDQERIQELMTKFGSILKDIQLKDKSSSKAKKEQQRTYGTEGDLAFSDGDSENGDVDGEPSDEVTEPFKLRISDLGYSEPASATMMEPEITIQEAIEIVVKKESQKIEFALFQAIEEGRGDMGLWEVCKERIFSVLQHLDENANITMPGAVNKTSSDDADVADSAHTHTSSGLFRIPAVVPIDQVITELYPRTLLIAFRLLNTHFPGSPLIGQFRTTIKDQGRASALLGSSVALYDEMIQFYWYGCNDLPAVVSFLHDMDVTGLEPSSRTRRLLKDIVRQRKRDLDHGDQPTHDQDSFWDFPPNKAAYEELAGPGGWLEKLRSRARESHEQRRLRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BU36</accession>
    <name>A0A9X0BU36_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">V-type proton ATPase subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_004726</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789522.1">
        <property type="nucleotide sequence ID" value="XM_056934328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BU36"/>
    <dbReference type="GeneID" id="81624577"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5484738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="213" mass="24204" checksum="A4B541A57AED70B9" modified="2023-11-08" version="1">MTAFIRQEALEKAREIQLKADEEFAIEKSKLVRQETAAIDTLYEKKFKQAAMSQQITRSTLSNRTRLRVLGGRQELLDELFEKARKKISTVADNDKKKYQTMLEGLILEGFYYLNEEKVELRARKQDADAVKKAVEGAAKEFKKNVGKEVTATLDESEPLPESSAGGVVLVGGKGKIEINNTFEERLRLLEIDALPAVRETLFGKNANRRFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUW7</accession>
    <name>A0A9X0BUW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L10-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_005597</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790393.1">
        <property type="nucleotide sequence ID" value="XM_056935199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUW7"/>
    <dbReference type="GeneID" id="81625448"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="13"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5485609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="112" mass="11865" checksum="3A2D426E93CB8009" modified="2023-11-08" version="1">MAPSKKSKKGSDNINSRLALVMKSGKVTLGVQSTMKTLRSGKAKLVIIAANTPPFASPSSSTMPCWLRLLFTISLETTDLQIELGTACGKLFRCSTMAILDAGDSDILTGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BV00</accession>
    <name>A0A9X0BV00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH TFE/IIEalpha-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_005450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790246.1">
        <property type="nucleotide sequence ID" value="XM_056935052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BV00"/>
    <dbReference type="GeneID" id="81625301"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="327"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5485462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="450" mass="49444" checksum="9CCB470F92B3EB84" modified="2023-11-08" version="1">MDLANTLIRSVARAFYETRHILIVDALFLHSVLHAEDLAFLMGMQQKDLRKLCARLREDRLIGVSTRAEIRDGSTRPVNREYYYIPLHPVIDAIKYKVSKLTSTIKEQYTPSEERKEYMCPRCLAEWTELDVLSLVSEEGFECQNCGAILERTEDIKGEEGIDRTGHEKNSKLMAQLDKMLKLLKQIDSVEVPPNDFDTAWDHKVEVPRNQSTHPVRAAVPVPPKAQDVIRGNLKTDAAALEISLTSSEEKSAAEQAEEAARKAAVEKQNALPVWHTHSTVDVTAPAQVKTETGLSIKSELDQDEQKPNLEAEDDKIAAYYAEMEREKALQAQEDASSAEDSDEFDDEFEDVGLSGASGPGTPATGLGPTSAPTPAGLSGVKRELDTSSAAPSTVGTPSTPADDGPAVKRVKVEPGLGGDTFIKPDPDAKTEPTVKDEESDEDDEEFEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYH3</accession>
    <name>A0A9X0BYH3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,4-alpha-glucan-branching enzyme</fullName>
            <ecNumber evidence="4">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycogen-branching enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_004082</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Glycogen-branching enzyme participates in the glycogen biosynthetic process along with glycogenin and glycogen synthase. Generates alpha-1,6-glucosidic branches from alpha-1,4-linked glucose chains, to increase solubility of the glycogen polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791225.1">
        <property type="nucleotide sequence ID" value="XM_056933684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYH3"/>
    <dbReference type="GeneID" id="81623933"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000001">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000250">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000003">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="12">
        <location>
            <begin position="195"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5489192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="686" mass="78097" checksum="873C9CA92DAA5968" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYK9</accession>
    <name>A0A9X0BYK9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin cytoskeleton-regulatory complex protein END3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Actin cytoskeleton-regulatory complex protein end3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytoskeletal adapter protein sagA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Endocytosis protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">N7539_002378</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the END3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791940.1">
        <property type="nucleotide sequence ID" value="XM_056931981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYK9"/>
    <dbReference type="GeneID" id="81622230"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000323">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein end3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000339">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein END3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025604">
        <property type="entry name" value="End3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12761">
        <property type="entry name" value="End3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="23">
        <location>
            <begin position="10"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="24">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="23">
        <location>
            <begin position="138"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00029684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAJ5490811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="404" mass="46761" checksum="DCA349DC020D2773" modified="2023-11-08" version="1">MSNKKIEQWEIERYWEIFSGLSNGQTHLNSSQAASVLRNSGLRDEQLEKVWDIADVDGDGELDFEEFCVAMRLVFDLVNGELQDVPPVLPDWLVPESKSHLVQATRALHRPEQFERIEDEDESLGLKDGFDWYMKPADKSKYEEIYNSSRTQRGDITFESLQPLYESLDVPDTDIRSAWNLVNPSAAQAINKDAALAFLHILNYRHEGFRIPRSVPASLRSSFQSNQIDYQIDNNTRPAQRWGTEGNQETRTGRKAKFGDTYLSRLGVGGKGSYQPKGTDFSETLQDEEWEKVRLRRELAEMEAKLKSAREASENRRDRPRNDGRPNWVLIKKEALQLLEYKERELRELREGVGRAKDGQELERAREDVKTVGEQVESLKTHLAQRQAILADLRHEIEEERSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYL5</accession>
    <name>A0A9X0BYL5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA-binding protein MRN1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_004413</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791556.1">
        <property type="nucleotide sequence ID" value="XM_056934015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYL5"/>
    <dbReference type="GeneID" id="81624264"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12520">
        <property type="entry name" value="RRM1_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12523">
        <property type="entry name" value="RRM2_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12521">
        <property type="entry name" value="RRM3_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12522">
        <property type="entry name" value="RRM4_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000047">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000064">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000130">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000120">
        <property type="entry name" value="Negative regulator of differentiation 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034195">
        <property type="entry name" value="Mrn1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018835">
        <property type="entry name" value="RNA-binding_domain_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF8">
        <property type="entry name" value="RNA-BINDING PROTEIN MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10378">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="182"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="273"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="407"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="498"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="566"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="760"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="576"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="605"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="627"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="762"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5489523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="825" mass="87516" checksum="21429311A1D71128" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYU5</accession>
    <name>A0A9X0BYU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arylamine N-acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791751.1">
        <property type="nucleotide sequence ID" value="XM_056934210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYU5"/>
    <dbReference type="GeneID" id="81624459"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="35959" checksum="CD8B1840E30C6272" modified="2023-11-08" version="1">MAPERAKYTDAQLEAYLERIAYSPADKSMPNLVEEARARIQNYPLEILSELQKLHLATIPWGNSSLHYSQHHTISLHPDSLYEKMVERRLDGYCMESTGLFFTVLRSLGYHVYATGGRVSPATSSGIDTGLFASLGHMILIVIIDDARYMVDVGFGINCATAPLPLQEGATATCIAPSEMRLVKETPIEFIDKSQKIWIYQTRKNPESPWLPGICFSEVEFLPQDFEAMNFSVSQRRTSWFTHQFVCVRMIMDPASKEIIGQCIISGKEAKKRIGGETQTLQVLENEQDRVHALAKYFGVHLRKHEIEGIRGFVSELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYW0</accession>
    <name>A0A9X0BYW0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_002633</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792195.1">
        <property type="nucleotide sequence ID" value="XM_056932236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYW0"/>
    <dbReference type="GeneID" id="81622485"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000247">
        <property type="term" value="F:C-8 sterol isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004769">
        <property type="term" value="F:steroid Delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF0">
        <property type="entry name" value="3-BETA-HYDROXYSTEROID-DELTA(8),DELTA(7)-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="7" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="15">
        <location>
            <begin position="59"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5491066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="287" mass="32906" checksum="0A6C686EA4C7A8F7" modified="2023-11-08" version="1">MENTLHSHPYYPVGASIAGYSPNESSLIELLVKAGGGCTALLGLTFILVSYARPRLCLHDRMAILWFMLLTAIPYVAGTLHCFFEGYFMVNHREMASAQDLFGQLWKEYALSDSRYMTSETLVLCMETMTVDLKLELDESLQGWSDLSLYKQLLWGPLCFWVVTLIITQDSLRHPIQLLVCMSHLYGDTLYYATSLFDHYAHNISYSRPEGYYFWLYYFFMNLIWIVVPFCESRSKKATVCQGRRLNIEDEYTSRLSGSKYSNFVDSRSIPAGVCGPFQNPLEPRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ15</accession>
    <name>A0A9X0BZ15_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791942.1">
        <property type="nucleotide sequence ID" value="XM_056931983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ15"/>
    <dbReference type="GeneID" id="81622232"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5490813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="586" mass="65283" checksum="04318B156E735D65" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZA3</accession>
    <name>A0A9X0BZA3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA repair and recombination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_002635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <authorList>
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            </authorList>
        </citation>
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        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
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            <dbReference type="PubMed" id="36726175"/>
        </citation>
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        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9X0C035_9EURO</name>
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                <person name="Frisvad J.C."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAJ5493058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040922000" description="AB hydrolase-1 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="84"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5493058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="347" mass="38507" checksum="8EC6A4509549A181" modified="2023-11-08" version="1">MRIFSAFSAISAISSYASFALAQSSPDPVGTIYDGDVPDNLYGSDYPYPWPVKLYNFYNQRQNLTMAFMDVPAPCEHDKNKVAVLLHGGNFCSVTWSDTARRLTAAGYRVIMPDDIGFCKSSKPQGYSYNVHQQAENIKSLLNVLGIEKATVMGHSMGGMIATRFGLMYPDNVDQLFLVDPLGLEDWVAKGVPYVPVDATYQGQLTQNFTTLKAYEQASYFHGAEWKPQYDKWVQMLANIYAGDYGSDYAYVMGLVTDALLSQPIFYHLPLLKTRTYLMVGEADVTALGKQQSPPEVVAKLGHYAELGPAAAAMIPNCTFHMFPGLGHAPFLQDPEAFYKVLLSWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0L6</accession>
    <name>A0A9X0C0L6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793831.1">
        <property type="nucleotide sequence ID" value="XM_056931800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0L6"/>
    <dbReference type="GeneID" id="81622049"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF1">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="137" mass="15078" checksum="F607C792C255F958" modified="2023-11-08" version="1">MSGPNLTRNISYGRGGAGNIAPPQRSTTPKDLVTPTIKQEVYTTGRGGSGNMVQNDPQHPELARESQDVESPPLRAEQFPHHTGRGGAANAYIPTPEEEQSARKEEAELVRVRTQSRDRLKEIELKRQEERHGSPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C289</accession>
    <name>A0A9X0C289_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Trypsin-like cysteine/serine peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_000453</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794350.1">
        <property type="nucleotide sequence ID" value="XM_056930057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C289"/>
    <dbReference type="GeneID" id="81620306"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000077">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040773820" evidence="6">
        <location>
            <begin position="20"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="23"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5495337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="252" mass="26100" checksum="1C658B1C7FCBC6C9" modified="2023-11-08" version="1">MKTYTVATLLLSVVGLTLANDDIVGGQHAAIGEFPYQVSVQTSSHRCGGSIIDKNHILTAAHCVDGLTAQRLRIRAGSLDRNSGGQFVKVSKVIAHAGYDAKSIANDMAILRLASSLTFGSRVAAVKLPSSTDDTPQVGTRCSVTGWGTTSPGGASMPSNLLVAYVNIVDHQKCAKEYADQHPLDDKMICAGVRAGGKGACDGDGGGPLVDASTGKQVGVVSSEPGCGKHNKDGVYASTAAYLDWIRNQTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2D4</accession>
    <name>A0A9X0C2D4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome monooxygenase aflU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_000156</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794053.1">
        <property type="nucleotide sequence ID" value="XM_056929760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2D4"/>
    <dbReference type="GeneID" id="81620009"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5495040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="500" mass="56553" checksum="3D3D05F68EDED885" modified="2023-11-08" version="1">MAGLAVWVVGGLLAYRMALVVYRVFFHPLRKIPGPKLAAMSTAYQFYYEIIKQGTFIWHLEKLHEIYGPIVRIGPREVHIKDSEYYETIYASSGRRREKDAAIVAQFDIPGSSFSSVSPEIHRMRRSPVEKFFSKGAINRTEQNVQKHLDKLVARLEQAQKAHKVVAMDAGFAAMTSDIIHEYVFGLHTGNLDQEDFNERIRDGVNGLFKLGHLSRFLPWIQPLMATLPRFLMDMLSPYAFALMDQKQFIHDQVVAIQTGQNKGSAGSVMEKLSGPGLPDHFKSARNLSDEGFALVIGGTETTARSLSVGLFHLLNEPRLIHKLREELRAVMPTPTSKPTWNQLEQVPYMMGVVLETFRLATGIASRSPRVAPSEALVYKDYTIPPGHMVSQVNYFVLMDPTIFPDPEVFDPERWTRAAAKGERLDKFLVNFSKGSRICLGMNLAYAEIYLTIATLVRRFELELFETTKENIAFARDFGTPYPDQGNYSLRVLVKGQVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2L7</accession>
    <name>A0A9X0C2L7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase subunit of RNA polymerase II carboxy-terminal domain kinase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794308.1">
        <property type="nucleotide sequence ID" value="XM_056930015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2L7"/>
    <dbReference type="GeneID" id="81620264"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="375" mass="41601" checksum="340E5D07840347AF" modified="2023-11-08" version="1">MAGTHRSPILRDSRSGDLGRESRDTELRRGRGSNRDRGRGRYYDRGGRSSQSSKQHYDNYNRSPPRGPRLGSDALHASKEFPSNRSTRPSPGPASTIRDDRKLGVRRSSISRDWGDTWDSNPTGSSRTSLREHSPSAPLAKRKRTRSPSPHSQRPPPRPRPFQNGNRRDRSPPSGPRGRLPGRGGIRGRDRWGKDHRRSDNLRSARSRSPARSGNHGNFRVSPDHRPRSPVDEQGEKGSRPRPRPRSLSRHSARSAGSKESTSSTFPQDDSSVHKSRAYQTGRSGHDRPHSPGHSLQAFNGNDVTKPNVGRGESQNGPFEQRQSSSRPPRGYTRSPSPGRKSSSWSRYGTPPPRSPNKRIGADDDGWGNSKSGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C335</accession>
    <name>A0A9X0C335_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_001222</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795119.1">
        <property type="nucleotide sequence ID" value="XM_056930826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C335"/>
    <dbReference type="GeneID" id="81621075"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF7">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="26"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5496106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="335" mass="37464" checksum="8C70C7C8BE333E18" modified="2023-11-08" version="1">MVGHNASVDNSTYTERSIDSFTERTILACLIGIAWYNALELIVLCFSTFKRYGGCYFWSLLVASFSVIPYGLGYLLIIFRIFPNEFSVAMELIAWVGMVTGQSLVLWSRLHLVVHSRRVLRACLAMIIIDAILFHLPAAVLEFGAHTHKADLFVPPFNVFERIQLIAFSLQEIVLSALYSYEAVRLLNLRPRGHYRGTLLQLLIVNLAMIFMDAAIIGVQYSGYFDVHVTLKAMSYSIKLKLEYAILGKLVHFTEMSHSTNSAPTDLSDFVDLSYYHPNQPRVPDGGSQTRFVGGPDSPYERCGQTPSKESSHDAGTSEASTRVSTSNEAVQRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKA4</accession>
    <name>A0A9W9WKA4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785644.1">
        <property type="nucleotide sequence ID" value="XM_056939149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKA4"/>
    <dbReference type="GeneID" id="81629399"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF279">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="45"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5466598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="457" mass="50093" checksum="BF26E6C6D34DC1EE" modified="2023-11-08" version="1">MDSNVHTPKPFPQPAAGYTQPFWRTELDDLDSHQSSADLPPETEILIIGGGYAGASAAYHLFNDAPQDKSLGVVLLEGRELCSGATGRNGGHLRPDLYAATKVYQERYGLEAAAEVVRYEISHMKQLEETVRNEGIDCDLTFTRSYDIFLDADHLAAAKAYYDSLVQYDLDFMSDVEYLTEKEAQTIAKVKNAKGGFSFSAGHLWPYKLVAGLIRIAVSRGLQLHTKTMVTGIGQTPSLEGFWPVTTSRGVIHARKIIFATNAYTSALAPEYSRAIVPCKGLCTQIQAAPGAPYEAIPETYVIRHGPGCFIYQISRKDGSIIVGGAEYTYRDSPAQWYSNSEDGSVIPNVETYFDGYMQRTFHGWEDSQATVKQKWTGVMGYSADSLPHIGAIPNKPGQFIAAGFNGHGMPVVFLGGKAVAEMAQKSISFSQTGLPRLFETTAERLTPIYDDTMGYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKV3</accession>
    <name>A0A9W9WKV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_009537</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785627.1">
        <property type="nucleotide sequence ID" value="XM_056939132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKV3"/>
    <dbReference type="GeneID" id="81629382"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000173">
        <property type="entry name" value="Heat shock transcription factor Hsf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="154"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="87"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="443"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="755"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="669"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5466581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="785" mass="85022" checksum="EAA4DEC047440D99" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKW7</accession>
    <name>A0A9W9WKW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_008966</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785938.1">
        <property type="nucleotide sequence ID" value="XM_056938561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKW7"/>
    <dbReference type="GeneID" id="81628811"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF43">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5469348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="548" mass="60701" checksum="98B3EC736B5D8BCC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLE8</accession>
    <name>A0A9W9WLE8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_009221</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786193.1">
        <property type="nucleotide sequence ID" value="XM_056938816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLE8"/>
    <dbReference type="GeneID" id="81629066"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5469603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="592" mass="66480" checksum="E9C96AE263B7CFB1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WMB4</accession>
    <name>A0A9W9WMB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_009361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786333.1">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5469743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="30606" checksum="3239A62B4FDD6D2F" modified="2023-11-08" version="1">MVKKKTKQRRAQEEPLNPMSVQVSPKVDYVQPLSSPYEGPVVTATIGNKQYCILGYCLRKCPQFEQQSVLSSYITLPYIHEDVGHTFVHFLYSGCYETIDSPVDDGISSAMREYRRSVLIYQASRTYQLPSLEALARDYIERFGEEMSISDILRTTSEVFSNLPEDETWLPKYIERNLRHSLRSSKSKFDVDELYKAFGQDHYFDNTVTRMMLEILLRPQGVHLAGREERLRTDTHSWEHGGEGIDWKSTGRDSWRATVDRSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQJ6</accession>
    <name>A0A9W9WQJ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_008795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786398.1">
        <property type="nucleotide sequence ID" value="XM_056938390.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81628640"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF155">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="33"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5471852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="191" mass="20860" checksum="6DE0A350D973C740" modified="2023-11-08" version="1">MISMDTVATQRTALMLLIVIWVLTLLATACVVIRLCVRKYMHICGLDDCIIGLSMGIGLSFAVAATLSIHHGYGQHYKELNSEQASKALMWNVISLLLGTFVCALTKLAVAAHLDRIWGRVLSLSSRNLMWILTGMAPLFALVTIIIFITECKPLNALWAPAMVEAGQATCRDVSTLILFATFNGGEEYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQX7</accession>
    <name>A0A9W9WQX7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786412.1">
        <property type="nucleotide sequence ID" value="XM_056938404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQX7"/>
    <dbReference type="GeneID" id="81628654"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5471866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="131" mass="15496" checksum="BB831156ACD118EA" modified="2023-11-08" version="1">MNFLENLSLSKDVCQFSELYNHHAGLSHPASITIAHSPVPVFSQSKPCCFNDLHYPSSFMPREYEWEITKEKWTKQSVVYLARCNKGDKSNSDNRREFQRQHLIFITWDERLSFKLLSRHERMALHDFDCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQZ4</accession>
    <name>A0A9W9WQZ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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        </citation>
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        <source>
            <strain evidence="2">IBT 30728</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Petersen C."/>
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
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            <strain evidence="2">IBT 30728</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5472024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5472024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="145" mass="16939" checksum="022FFDA58D85BCFA" modified="2023-11-08" version="1">MLRLRKFINHATSDNKKLQIENKELKKNMPTPLVESVDVLQQQLQRREYHIDKLEEKNRHLEQKIDWMETLLLTETKNNLDLIIDGVERVDLKLISEAAICLLSNHELQVRKIDSGRAIATGPTSWFSSSLHKVSKLPMPFPLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9W9WR56_9EURO</name>
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        </submittedName>
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                <person name="Frisvad J.C."/>
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            </authorList>
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        </citation>
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            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <end position="34"/>
        </location>
    </feature>
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        <location>
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            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="173" mass="18762" checksum="93A1B0BDC1623B31" modified="2023-11-08" version="1">MERVDAGDGTPGEKYFTGQTSRNCQGEQYSSKYQPTVVDGLHEIDDNDADDSFANDDLGDSDVEAVLDDARRFLGDISAGHESHPSGAANTELDPNASVPASCLADDDDRHALPIKEQIDISEAFSEKGSHELRRKRRLSSTVGPQSPPTIQESQGPPSQWREPNGISPSQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAJ5472082.1"/>
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            <end position="137"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="138"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5472082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="147" mass="16738" checksum="9FC1F1E281EAE959" modified="2023-11-08" version="1">MNSITKAVQVESRNTMNSAIDDWQTDDEQTIPTPGAHTPLFERKDQPLPPFAQSILTQSLSDLENRDSENISSPSTLRRLMFSAEEENDVLGKIRLLMLGEQEGNSSPVQSRPHQVKRGWPRGERLERTRLDTRRCENTANDQSSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WT15</accession>
    <name>A0A9W9WT15_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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                <person name="Nielsen M.R."/>
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                <person name="Frisvad J.C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5474954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="109" mass="12237" checksum="6601C854B73B3449" modified="2023-11-08" version="1">MAGKLVQASEREQQHSWSHAQTYESAKEHFHIQSEPILQLYTPPPRPAIAQANLEYSSKAAKLPVIPDLPSLDHLLRFDQEAVTALPHPWARLSTATQLHPVPNAPRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTP0</accession>
    <name>A0A9W9WTP0_9EURO</name>
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        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">N7539_008360</name>
    </gene>
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                <person name="Petersen C."/>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_056937960.1"/>
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    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF52">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5475294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="313" mass="32736" checksum="1E79A678E2E1144F" modified="2023-11-08" version="1">MTASENTNGTHTRPVLTKGVYVPTVAFFQPDEEVDVATTEKHAAYLARSGVSGLVTQGSNGEAVHLDRQERKAITSATRRGVAAAGHPHLPIIAGCGAASTRETIQHCRDAAEAGADAVLALVTREALHAHFVAVAGASPLPVLLYNFPGASAGVDLSSDDILTLAAHPNIVGCKLTCGNTGKLARVAAGAKPGFLTFGGSADFTLPTLIAGGHGVIAGTANLIPRSCLYLMDLYEQRQLEEAQRIQAIVARADWVAVEGGFIAVKSGLQTYHGYGGLPRRPCVMPEPTVAATIHERFSEGLELERSLEKKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTV2</accession>
    <name>A0A9W9WTV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_007712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787178.1">
        <property type="nucleotide sequence ID" value="XM_056937313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTV2"/>
    <dbReference type="GeneID" id="81627562"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5475425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="62" mass="6804" checksum="0F8C4B1B5FEB80E7" modified="2023-11-08" version="1">MALARYIIRDRVVDPRGETPLLVPIAVTGTGTGTDLDLDLDLADVRVLHLPDTDGWNTDRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUW3</accession>
    <name>A0A9W9WUW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_007246</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787646.1">
        <property type="nucleotide sequence ID" value="XM_056936847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUW3"/>
    <dbReference type="GeneID" id="81627096"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF2">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5477102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="667" mass="73922" checksum="C8282AAA714DAB99" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV93</accession>
    <name>A0A9W9WV93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_007485</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787885.1">
        <property type="nucleotide sequence ID" value="XM_056937086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV93"/>
    <dbReference type="GeneID" id="81627335"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000004">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_uS3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="24"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5477341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="264" mass="28949" checksum="8B25CF237C9B6D88" modified="2023-11-08" version="1">MAAVQGAISKRRKFVADGVFYAELNEFFQRELAEEGYSGVEVRVTPTVTDIIIRATHTQEVLGEQGRRIRELTSLIQKRFKFPENSVSLYAAKVQNRGLSAVAQCESLRYKLLNGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRAARAKSMKFTDGFMIHSGQPAKEFIDSATRHVLLRQGVLGIKVKIMRGSDPEGKSGPQKTLPDSVTIIEPKEEQPVLQPMSQDYGAKALAAQQAAEQQRLAEEQAASAEGGAEAYAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVT2</accession>
    <name>A0A9W9WVT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787989.1">
        <property type="nucleotide sequence ID" value="XM_056937190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVT2"/>
    <dbReference type="GeneID" id="81627439"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="SET_dom"/>
    </dbReference>
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        <property type="entry name" value="SET_dom_sf"/>
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        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="44"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="368" mass="41618" checksum="2A03C99159A341CE" modified="2023-11-08" version="1">MANTPSRVTTVTKVTCTPQLSLSALSTAATDKEIIGKQSRWVHPHLIESIDPIKGRQLRASQDIPAGTCILIDCPYAIIPVVDNPVTNEGLLCSNRACNRALRAPASRVVCSKSCLSDVAWCSTTCRDSNMAYHNFECNWLKRYAVPIRKKWGEYIFGMSWVIVRLLASQHVERITRLEDEEVRPMHEWKCDWRGVESLCGSVDSWSHEQVRSWTLLVKKYLQKSAVLPHDMTPDQVLHLICQEEANSFGLYPRETGIYPCPEPPIDRGEQYAAAVYPIAAMANHSCIPNMMHKPDESGRMIFTASQDILAGQECCISYFDLTEHINLTSRREHLRKSFRFTCQCHRCASEAPAQNSSDWSAMPLMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1H1</accession>
    <name>A0A9W9X1H1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788144.1">
        <property type="nucleotide sequence ID" value="XM_056936209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1H1"/>
    <dbReference type="GeneID" id="81626458"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5480714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="249" mass="27009" checksum="6593398EBDF5DDFF" modified="2023-11-08" version="1">MAKPTIIFAPGAFCPPKIFDGLSQKLNEHGYTCYVVSFPSVEQASSVRDLQPDIDAVRRLVQPEVDGGREVIVVSHGWSGLPVSSSLDGLGRSERANQGKSGGVTKLVFVAAFIPQVGESMISAFGGHLPPWHVRDETTGTVTASDPFALFFHDVPNGREWAQSLRPHAWSTMASPATSAAYLKIPCSYLLCVNDFALPLVVQQLMADRAQRRGAVMETEKINSSDSPWLAVPDDVVAYLRRQAGETLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1I9</accession>
    <name>A0A9W9X1I9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788174.1">
        <property type="nucleotide sequence ID" value="XM_056936239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1I9"/>
    <dbReference type="GeneID" id="81626488"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5480744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="690" mass="73120" checksum="C6AA6BBA5598D556" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1N9</accession>
    <name>A0A9W9X1N9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 21">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="6 21">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19 21">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18 21">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">N7539_006698</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 21">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="21">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 21">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 21">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="6 21"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788234.1">
        <property type="nucleotide sequence ID" value="XM_056936299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1N9"/>
    <dbReference type="GeneID" id="81626548"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000009">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.20:FF:000009">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 21" id="KW-0436">Ligase</keyword>
    <keyword evidence="15 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 21" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="23">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAJ5480804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="519" mass="57173" checksum="BFD796CA6DF0F0EC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1Z9</accession>
    <name>A0A9W9X1Z9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_006669</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788205.1">
        <property type="nucleotide sequence ID" value="XM_056936270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1Z9"/>
    <dbReference type="GeneID" id="81626519"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF17">
        <property type="entry name" value="OXIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="44"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5480775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="479" mass="51365" checksum="25AA332D0BC01C39" modified="2023-11-08" version="1">MGNSQSLPGHNCLLAAVDHRASLVTFQNDALFHLRAPSLYNLDAPVKPLAVTFPENSEQIAKIVQCAARHSLKVQSRSGGHSYGNYGLGGQDGAVVVDLKSFQEFSMDPVTHVATVGSGTLLGDLHSRLYNAGHRAVAHGACLSVGLGGHATIGGLGSMSRQWGMALDHIQEAEVVLADGKIITASATENPDVLFAIKGAAASFGIVTKFKLITHPAPTQAVQYSYSLNIGTTAQRARLFADWQRFIYTQNLTRRVSSELVVFEHGVLISGTFFGSPEEWKSLEKKLKFPGADKGNLIVLTDWLGMLVSGAEDLIQQVAGGTPCSFYAKSMSFTDALSAEGVESLFTYLDSATKGTPAWFVIFDLEAGATNDVPNNATAYAHRDTIMWMQSYAVSLIGPVSSTTKDFLGGINQVIAATCPSASYGAYPGYVDPLLENSQQAYWGDNLPKLQKIKSDIDPHDVFHNPESVRVNPAARAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X203</accession>
    <name>A0A9W9X203_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_006586</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788122.1">
        <property type="nucleotide sequence ID" value="XM_056936187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X203"/>
    <dbReference type="GeneID" id="81626436"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="PITH" evidence="5">
        <location>
            <begin position="126"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5480692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="36965" checksum="9C08C58352DBEEA0" modified="2023-11-08" version="1">MAVVNISSAGQFNSLLSSSRFVVADFYADWCGPCKAIAPVYEKLASQLSRPNHITFTKINGDQQMEIAQAYSVVAYPTFIVFENGRSIKTVTGPDPQKLTEVVRKLATEASKSDGDAGESSGAIWLGAEVASRYADVTDQVEVKGLDLLNRDTQLGGPRALFETFKPSALTGKGKSKSEAGSSSSSGADWIESDTDEQLMLYIPFQSKLKIHSLHITSLPPTGEADEDEDEDERPMRPRTLKLYTNTSHILGFEQAEDTTPEQTIEIQPEQWDSKTGTATVDLRFVKFQNVTSLVIFFVDGDGESEKLRVDRVRIIGEAREKTSLGKLEKIGDEPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X232</accession>
    <name>A0A9W9X232_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/arginine-rich splicing factor SR45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788416.1">
        <property type="nucleotide sequence ID" value="XM_056936481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X232"/>
    <dbReference type="GeneID" id="81626730"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5480986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="103" mass="11869" checksum="D039BA79C4AEEF96" modified="2023-11-08" version="1" fragment="single">MFTRSPRGRSPMRSPDPGLPKLPRSHNRSRSYTRSPAPERHRRSRSRSDSVSRERSLSRSRSRSRSRSPVRGGRRYRSASRSRSRSLSPVQSPPRSSKVVVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2K7</accession>
    <name>A0A9W9X2K7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Rhamnogalacturonase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_006984</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788520.1">
        <property type="nucleotide sequence ID" value="XM_056936585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2K7"/>
    <dbReference type="GeneID" id="81626834"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046576">
        <property type="term" value="F:rhamnogalacturonan alpha-L-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronide lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF19">
        <property type="entry name" value="PECTIN LYASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040958571" evidence="11">
        <location>
            <begin position="20"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5481090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="446" mass="47106" checksum="EF57ADDBFF5940CA" modified="2023-11-08" version="1">MVYLLSLLALGMAPLLATAQLSGGVGPTTPYATKANHKTCNVLKYGAVADKKTDVGPAILSAWNDCKSGGVVYIPAGDYALGSWVTLNGGKSTAIRMDGTIYRAGASGGNMIFVEHTDDFEMFSATSKGAVQGSGYEFHKKGSLSGPRILRMFKVTNFSVHDLALVDSPSFHFSMDTCENGEVYNMAIRGGNSGGLDGIDVWSNNIWVHDVEVTNKDECVTVKSPAKNILVENIYCNWSGGCAMGSLGADTAISDVHYRNVYTWASNQMYMIKSNGGSGTVSNVVLENFIGHGNAYSLDIDQQWSSMHTIAGNGVHLDNITVKNWKGTESNGAQRGPIKVNCAAGAPCTDVTLVDFSMWTETGNYQKEICNNAYGSGGCLKPGTGGSYSTTVTVKTAPTGYSAPTMAADLKAAFGTDSPIPIPTIPTSFYPGQTPIKALAAKATTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2Z8</accession>
    <name>A0A9W9X2Z8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Gaa1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_006374</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788900.1">
        <property type="nucleotide sequence ID" value="XM_056935976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2Z8"/>
    <dbReference type="GeneID" id="81626225"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000121">
        <property type="entry name" value="GPI transamidase component (GAA1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="648"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="722"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="750"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="794"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="840"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="884"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="7">
        <location>
            <begin position="92"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="682"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="684"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5482928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="910" mass="100079" checksum="5391628E16BEEF7B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X337</accession>
    <name>A0A9W9X337_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788722.1">
        <property type="nucleotide sequence ID" value="XM_056935798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X337"/>
    <dbReference type="GeneID" id="81626047"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5482750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="556" mass="63299" checksum="D70C15BBA79BECE9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X376</accession>
    <name>A0A9W9X376_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxidase</fullName>
            <ecNumber evidence="8">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_006475</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789001.1">
        <property type="nucleotide sequence ID" value="XM_056936077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X376"/>
    <dbReference type="GeneID" id="81626326"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF36">
        <property type="entry name" value="L-ASCORBATE PEROXIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 8 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="10">
        <location>
            <begin position="88"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5483029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="309" mass="34058" checksum="E02D24B34052343C" modified="2023-11-08" version="1">MSRHGDFDAVRKDIAAQLQKPGYDDGSAGPVFVRLAWHSSGTYDAETDTGGSNGAGMRYEAEGGDPANAGLQHGRAFLEPIKEKHPWITYSDLWTLAGVVAIKELGGPDIPWQGGRTDLVDDSKVPPRGRLPDGALGADHLRFIFNRMGFNDQEIVALAGGHNLGRCHGDRSGFEGPWVTNPTRFSNSFFKLLLQLDWKPRKLATGMTQFVYEDPDAEEDEEPLMMLPTDMALKTDPGFLPWVQRYAEDKELFFDHFAKVFAKLVELGIKRDAEGNVINTDNQLGGYLSAPKKSNVPTGSAKDQPRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3J4</accession>
    <name>A0A9W9X3J4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_006519</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789045.1">
        <property type="nucleotide sequence ID" value="XM_056936121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X3J4"/>
    <dbReference type="GeneID" id="81626370"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000247">
        <property type="entry name" value="Flavin-binding monooxygenase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5483073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="61133" checksum="5CC98FFC0F7AB777" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5J5</accession>
    <name>A0A9W9X5J5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789431.1">
        <property type="nucleotide sequence ID" value="XM_056935559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5J5"/>
    <dbReference type="GeneID" id="81625808"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="540"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5484161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="720" mass="79288" checksum="123AFD73786897EB" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5M4</accession>
    <name>A0A9W9X5M4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanine deaminase</fullName>
            <shortName evidence="8">Guanase</shortName>
            <ecNumber evidence="8">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_006002</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>guanine + H2O + H(+) = xanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="8"/>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789476.1">
        <property type="nucleotide sequence ID" value="XM_056935604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5M4"/>
    <dbReference type="GeneID" id="81625853"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006147">
        <property type="term" value="P:guanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000022">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014311">
        <property type="entry name" value="Guanine_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02967">
        <property type="entry name" value="guan_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF49">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="83"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5484206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="463" mass="51262" checksum="4D76BC595F617841" modified="2023-11-08" version="1">MDDLHLTSIPASGLPLAFYGTAVHSRTLTELEFLENCLIVVDQAGKIQALQQNVDASQINTILADQGYAPEVFPVKHMRRGQFLCPGFVDTHNHAPQWTQRGVGRGRSLNDWLNQVTFPHEAKFADIEYAKRTYAACVSGFLQQGITTASYYGSHHGDATSVLAEICLEKGQRALVGKCNMNRNAPDWYREASTKESLEATRAFIQHVARLDPEGQLVKPVITPRFAISCDDELLSGLGSIARANPKVPIQTHFNEEDGEIRFTRELFPQFRTEADLYQHFGLLTDQTILAHCIYLAEGEIDQLRQLGCGVAHCPIANTTMLNFMIAPIREYLRRGINVGLGTDSGGGHSSSMLEAMKQAFVVSLARYTQTEGEDEPLSLEEGFYLATRGGAQVCGLEDKIGTFEVGKEFDALEVHMVDLDIPSVSSPIEEEDSTLVIFEKFLMTGDDRNIAKVYVQGRSVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5N6</accession>
    <name>A0A9W9X5N6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_004695</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789491.1">
        <property type="nucleotide sequence ID" value="XM_056934297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5N6"/>
    <dbReference type="GeneID" id="81624546"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="35"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5484707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="553" mass="59737" checksum="DCEFCEDB6650D6AD" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5N8</accession>
    <name>A0A9W9X5N8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_004812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789608.1">
        <property type="nucleotide sequence ID" value="XM_056934414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5N8"/>
    <dbReference type="GeneID" id="81624663"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5484824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="331" mass="36341" checksum="831733ABD75CFED2" modified="2023-11-08" version="1">MASSRLPSFSSGDIVQLVCRYAPASTDLHHRGEVKGLLERVVGQDDFAAVVTKWQLSYLAATVTCSVRAGGCQSWTMKMVMNPACLWIGLYSAPSVPQDSQRSSEVSSESFTGCSSMSGLLEGITALRPLDFHNEWSPLIRGLSAFLENATQADTEDVMHVDPVGSVDSSEDDAMTIDEDDISNVDIDIRDFPTPPPSDADIDLWDAPSPPSLDVDIDIPDSPSPPVTDVDIDFPDSPAPATTDDDMVNIRLSQTVSSRWFPDRRCDSLNFSGAPLQVGNLDVTDRARWVRKKQSKSILLAAERRRWIRAGDKRRAWMARNFVALVRGKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5P8</accession>
    <name>A0A9W9X5P8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_004793</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789589.1">
        <property type="nucleotide sequence ID" value="XM_056934395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5P8"/>
    <dbReference type="GeneID" id="81624644"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="42"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5484805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="488" mass="54051" checksum="1E96003A743C9D7E" modified="2023-11-08" version="1">MDSSKPEQRPSDLDLADEVSSVPTVEEEKLERTLMRKIDLHILPFVVLLYLFSFLDRVNIGNARLYGLEDDLDLVGNQYQVAVSILFVTYCLFEVPSNLVLKKLRPSRYIAVISVLWGIIATLTGICQSYGGLLACRVLLGVVEAGLFPGLITYLTLFYSKSEIALRTGYLFSSAAVAGACGGLLAYGIGFMDGIAGLRGWRWIMILEGIPTVIMGVATWFFMADEPDTAYYLNEDEKALVVRRRSRHVGQTASAQKFHWADVKEGALDWRIYAFCIGQFAVDTMLYGYSTFLPTIIKGMGRWSTAEVQALTIPCYGLGAIAYLIVAWLSDRTQRRAFFICLFSAISVVGYGILISDASSGVHYFGALMVALGLYVTVGLPLAWLPTNLPRYGKRTFATGLQLTFGNISGVMAPFLYKNSEGPRFIRGNAVTLALVGFAGILYGILWFYLDAVNKRRAKGVYDEKIASLSEAETQELGDRNPRFRYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X648</accession>
    <name>A0A9W9X648_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_004980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789776.1">
        <property type="nucleotide sequence ID" value="XM_056934582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X648"/>
    <dbReference type="GeneID" id="81624831"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF178">
        <property type="entry name" value="CYTOCHROME-B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="86"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="200"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5484992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="50101" checksum="A740F06C15F97005" modified="2023-11-08" version="1">MLTCIPSPAGVPIRNVAAESLNARNPFESVHVLEVPKQGRHGAIRGELQDADQHIDSQNVASARGGVLLRGNNTPKLCEWKRIVRMKELTTEKLKLHKKKTDLWVAIQGKLYVVTEYASHHPGGLDILLDVAGQDATAAYKDVAHSEDANEILESYLIDTLKDATNFKRWEGVRLVQHPLIPPKASNNSDSMVKLGVAAGTALSLRLVLLSQESSVNIRELSRHLPQLGRVVTGKLSDSLPHDEIVSGALAKAAYSTVLKSVVTSRLSKLVETENGFTNLPFGQHVVIKANFDGQFVSRSYTPRTNSLKLGRLDLVIKYYEDGFLTGKYMAKLEVGDKVLFRGPKGSTRYKNGLGKKLGMIAGGTGIAPMCQLSRVICEDEIDTTEISPIFANRKEEGILLRTEPEAYVEASPRTLRVWYMLDHPPQKRQYGNGYMMPAVMRERRTSSQLIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X693</accession>
    <name>A0A9W9X693_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789635.1">
        <property type="nucleotide sequence ID" value="XM_056934441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X693"/>
    <dbReference type="GeneID" id="81624690"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5484851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="191" mass="25811" checksum="83B2AFCD201275B1" modified="2023-11-08" version="1">MVRHWPLSASLFCLHGHGHGRRSCLATSTCGYKKWLPDGRVLVWWLGPREPKENSSTFLGRGAVHGYSLNGNYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYHYYYYHYYYYHYYYYHYYYYYYSSSYITRYFKCKKHTALYVRDSLYSGVNNSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6Q0</accession>
    <name>A0A9W9X6Q0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">eIF-2-alpha kinase activator GCN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_005363</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790159.1">
        <property type="nucleotide sequence ID" value="XM_056934965.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81625214"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
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        <property type="term" value="P:cellular response to amino acid starvation"/>
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        <property type="term" value="P:regulation of cytoplasmic translational initiation"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="eIF-2-alpha kinase activator GCN1"/>
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        <property type="entry name" value="Translational activator, putative (AFU_orthologue AFUA_2G07960)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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    </dbReference>
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        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
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    </dbReference>
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    </dbReference>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00072275"/>
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    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5485375.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="2675" mass="291459" checksum="ADB63130CB73BC2B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6V4</accession>
    <name>A0A9W9X6V4_9EURO</name>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">N7539_005189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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    </feature>
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        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5485201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="197" mass="20200" checksum="AB20CC53E014CDA5" modified="2023-11-08" version="1">MSTNRPFLANFLAAFRAQSTLKSASPQPTSSSSRSAAPISTNVRTITSKPAHHQHQSQQYSSATNTSTATPAPAAASATGAGSSTSASSNLTYSSTNHYYSDTLTSTQPPQATAGPAVSPTTSTPIPISRGPDRQRRGSDSSSGSGGFRDALGPEKWYIGGRSAGGEERFYRLGMVTKGGGRLGGGGRVGSIDQLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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        <name evidence="1" type="ORF">N7539_003434</name>
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    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="2819901"/>
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        </lineage>
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                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5488544.1"/>
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        <property type="entry name" value="FLAVIN-CONTAINING AMINE OXIDASEDEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAJ5488544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="60276" checksum="5CE20015E5DA7593" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCB1</accession>
    <name>A0A9W9XCB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790709.1">
        <property type="nucleotide sequence ID" value="XM_056933168.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81623417"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="745" mass="81971" checksum="00E1D23E4BDCF3E3" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCF1</accession>
    <name>A0A9W9XCF1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_003486</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790629.1">
        <property type="nucleotide sequence ID" value="XM_056933088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCF1"/>
    <dbReference type="GeneID" id="81623337"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF34">
        <property type="entry name" value="PROLINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="111"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5488596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="453" mass="51211" checksum="26A6CD93ADF2B33A" modified="2023-11-08" version="1">MSMRSVTIHQSRCRSDSTKQKFHSVTFSSEATQLERPAMSRLPTARLIRSLILTSLMSSKLFLRPALGLLKLVTHSKSGVFDPDRNWILNKFLRWTVYDHFCAGTNRNEVAKTIARVKSMGFQGVILGYSKEIVIDPDIPTSTHDINLALHSSQDDRAIEEWKDKTLETLRMVGSGDFLAMKLTGAGPLAVRLMKERQPMPTIIATAVDVICKEAQKQGSRLWLDAEQQVLQHGLDDWAIEMMRKYNRSPHPLVYNTIQAYLKGSTANLDRHLLSATQEGWSVGIKLVRGAYIEHETRSLIHDCKEDTDRSYDFLANRILCRVMPDHGNHLAFPDAALFLATHNAESASKAISVHRNCLMSGQPTVSLDCGQIQGMADELGCELAQNYERACRQDRDGDVTFPKTFKCMAWGSVGECLQYLHRRAIENKGAVERTEHMLQALRKELRRRLLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCQ6</accession>
    <name>A0A9W9XCQ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_003774</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790917.1">
        <property type="nucleotide sequence ID" value="XM_056933376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCQ6"/>
    <dbReference type="GeneID" id="81623625"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="4">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="32"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5488884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="108" mass="11767" checksum="D2B81083D75B1441" modified="2023-11-08" version="1">MGVTEIKSAKEWEDLVVKSKEPVVVDFFATWCGPCKAVSPLVEKLSESATSVKFYKVDVDELSTVAAENGISAMPTFLFYKDGQKRDDLTVRGAQPPLIQKAVAEIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCX5</accession>
    <name>A0A9W9XCX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790899.1">
        <property type="nucleotide sequence ID" value="XM_056933358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCX5"/>
    <dbReference type="GeneID" id="81623607"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="118" mass="13174" checksum="1CC0933DDBDE924C" modified="2023-11-08" version="1">MKITTPTPESDACPYSPKSETPFASQQVTNDKAPVNSQQDSGRSTATKQPPSRGNRIGVKMLQFFEAFNDPLGNFIDDPVPEAVIAIPKPQKCRRPDKSTKAAKRVWKLVRRMFPSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDB7</accession>
    <name>A0A9W9XDB7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791260.1">
        <property type="nucleotide sequence ID" value="XM_056933719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDD8"/>
    <dbReference type="GeneID" id="81623968"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000019">
        <property type="entry name" value="Quinate pathway repressor protein QutR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002254">
        <property type="entry name" value="Quinate pathway repressor protein QutR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000386">
        <property type="entry name" value="Quinate repressor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF27">
        <property type="entry name" value="QUINATE REPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01100">
        <property type="entry name" value="SHIKIMTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="9">
        <location>
            <begin position="566"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="8">
        <location>
            <begin position="707"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="10">
        <location>
            <begin position="848"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5489227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="905" mass="100965" checksum="7900CBE50F8DE5E1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDP3</accession>
    <name>A0A9W9XDP3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING zinc finger-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791503.1">
        <property type="nucleotide sequence ID" value="XM_056933962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDP3"/>
    <dbReference type="GeneID" id="81624211"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056929">
        <property type="entry name" value="Znf_RING-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25080">
        <property type="entry name" value="zf_RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RING zinc finger-like" evidence="2">
        <location>
            <begin position="449"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="532" mass="58876" checksum="F1F34F5D00AAB434" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDW5</accession>
    <name>A0A9W9XDW5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">alpha-D-xyloside xylohydrolase</fullName>
            <ecNumber evidence="5">3.2.1.177</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_004372</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of terminal, non-reducing alpha-D-xylose residues with release of alpha-D-xylose.</text>
            <dbReference type="EC" id="3.2.1.177"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.177" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791515.1">
        <property type="nucleotide sequence ID" value="XM_056933974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDW5"/>
    <dbReference type="GeneID" id="81624223"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061634">
        <property type="term" value="F:alpha-D-xyloside xylohydrolase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06593">
        <property type="entry name" value="GH31_xylosidase_YicI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000053">
        <property type="entry name" value="Alpha-xylosidase YicI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1760:FF:000009">
        <property type="entry name" value="Sugar hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000057">
        <property type="entry name" value="Sugar hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007940">
        <property type="entry name" value="PRK10658.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF4">
        <property type="entry name" value="MYOGENESIS-REGULATING GLYCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="8">
        <location>
            <begin position="55"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="7">
        <location>
            <begin position="275"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="9">
        <location>
            <begin position="599"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00052064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5489482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="762" mass="86200" checksum="58353D1CB1152E1D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE29</accession>
    <name>A0A9W9XE29_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Squalene/phytoene synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_003927</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NDUFAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791070.1">
        <property type="nucleotide sequence ID" value="XM_056933529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XE29"/>
    <dbReference type="GeneID" id="81623778"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NADH dehydrogenase (Ubiquinone) complex I, assembly factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
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    </dbReference>
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        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE) COMPLEX I, ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5489037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43232" checksum="73CAA9818221A676" modified="2023-11-08" version="1">MPFFRNIARPCRATRSCWFSRQNQRSHSRGLSRTAPVGATPTPEEVQGAHRYCVSLLSKYDRPSYTLSTFIPQHARSFYIALRALNVSLSMIPETTSSPTIGLMRLQFWRDAVTKTLAGSPPKEPVAILLASAISDLHERTQGRAKITRGWLTRLINAREQTLTNDPYPNIAALESYAENTYSTLMYLTLGALPMTSVTADHVASHIGKAVGIAAVLRGLPLVAFPPPSPQSPSGPPGMNGGVKQGAVMLPLDIMAQNGVKEEEVLRRGADAEGLRDAVFAVATRASDHLITVDQMLSNLRAGKDVGHDFEHEGEEGHEYQTTAMGESRGNESPLDEVNRAFGVFMPAVATRLWLERLQQYDFDVFRPELLSGDWRLPWKAYMAFRRKNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEY6</accession>
    <name>A0A9W9XEY6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792051.1">
        <property type="nucleotide sequence ID" value="XM_056932092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEY6"/>
    <dbReference type="GeneID" id="81622341"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5490922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="78" mass="8387" checksum="B004E32BEF0E6558" modified="2023-11-08" version="1">MFSDSPIPKILASGSLAWTRALRSRAGQHEALDVLRLGAHGPLDMAVAQFKTIPDSSLSVDMQSMGDDPTHFHPTRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF62</accession>
    <name>A0A9W9XF62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosome assembly protein Noc2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_002609</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792171.1">
        <property type="nucleotide sequence ID" value="XM_056932212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF62"/>
    <dbReference type="GeneID" id="81622461"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="714"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="714"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="735"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5491042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
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    </evidence>
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    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000017">
        <property type="entry name" value="Ccaat-binding factor complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="9">
        <location>
            <begin position="87"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="176"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5491599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="274" mass="30229" checksum="1A8A65515293137D" modified="2023-11-08" version="1">MDQASQNAQQQARQQQQQQQQPQPGALYDVRNGGHYGASAALAAQGFAPVSDLYTGTWANVNQGLQGTARDILTTYWQHVISHLETDNHDYKIHQLPLARIKKVMKADPEVKMISAEAPILFAKGCDIFITELTMRAWIHAEDNKRRTLQRSDIAAALSKSDMFDFLIDIVPREEATSHAKRSSQAGAGGPGQAPGPGQMPPTQHGLSQHMGPTDYGSLGPHGMPQENEYRQQQAMYPGAVQQDPTGAYGQPQPQIFEGMYAYHQMPPQQVRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGU2</accession>
    <name>A0A9W9XGU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 18">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="16 18">1.3.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">C-24(28) sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Sterol Delta(24(28))-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">N7539_003080</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15 18">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="16 18"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792642.1">
        <property type="nucleotide sequence ID" value="XM_056932683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGU2"/>
    <dbReference type="GeneID" id="81622932"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000003">
        <property type="entry name" value="C-24(28) sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF31">
        <property type="entry name" value="DELTA(24(24(1)))-STEROL REDUCTASE ERG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10 18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13 18" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ5491513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="471" mass="54582" checksum="E75062774D1A0B15" modified="2023-11-08" version="1">MAVSSRATKAGASSARTTSNHTSTRAAQFVDGASDEFEFGGAMGSAMLMSGFPLLMWYMWIGATYYDGKLPLPEADQTWIEFGRHLCHLVYEGAYPTSKAWATYWIFFIVEALMYCYMPGVSGYGRPLKHEGGKKLPYYCSAYSSLYATLGLAAILHATGIYSLYTLIDEFGPLMTVSILSGFLNSFIVYFQAIIRGRTHRLSGSPIYDFFMGAELNPRIGMLDFKMFYEVRIPWFILLLITCSVAARQYETLGYVSAEVVFLVGAHYLYTNACAKAEEMIITTWDMYFEKLGFLLTFWNMAGVPFTYCHCALYFANHDPSEYRWNRFALALFAALYIFFYWMWDSANGQKNAFRHKTRGEFHKRNTFPQVPWQAIENPMTIRTDAGDDIMVDGWYAIIRKPNYVPDMFFSFAWGMITGFKSVFPWFYFVFFMMMILHRTNRDVNRCRRKYGEAWKRYEKEVPYLFVPYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGZ4</accession>
    <name>A0A9W9XGZ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793177.1">
        <property type="nucleotide sequence ID" value="XM_056931146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGZ4"/>
    <dbReference type="GeneID" id="81621395"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040797616" evidence="2">
        <location>
            <begin position="18"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5492797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="294" mass="32974" checksum="A59450CA61623ABB" modified="2023-11-08" version="1">MKRSLLSFAMNLAAVAAMPSHRPSSPTYFFTFGDSYSMTSFNVNGTQPSPSNPMGNPQLGTGATGGGINWIGYLTTVDNSSLVLSYNLAIGGATIDNAILNSGYPDMTGQVKTFQDVYSAKPMKAPWKASDTVFGFWIGVNDVGWAYQSYEADELVPKLMAQYRSLIEEVYLDGGRKFLFINVPPTGRSPLILDQGESASQKHAAWTEAYNRGLEEMRKEFHTAHKDVESVLYDSWRFMTRILDHPRWFGFPNATCIDSDGESCVWWNNYHPSQKYHRLQAADMKRTLHRFGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH74</accession>
    <name>A0A9W9XH74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793297.1">
        <property type="nucleotide sequence ID" value="XM_056931266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH74"/>
    <dbReference type="GeneID" id="81621515"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="195" mass="20904" checksum="ABF18F5CDC2AF6F3" modified="2023-11-08" version="1">MTSLVIALVSQGRNPDATVTNIFVPVKSNFERVISCSGAYDSVDTNCSPSHGLQYQATGWSVSWNKKINLAFLLPYLQSGVILNILNYEGSNAAFTVGPQTVYQTLDPIKAALSSIQTTNIGADANVTMFGYSGGGFATEWATEIRAWYAPKLPIVGAVIGGPSPNVTSTYYNVNKVPLSILNGAAILRIMSEWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH84</accession>
    <name>A0A9W9XH84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cell division control protein 42 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_003305</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792866.1">
        <property type="nucleotide sequence ID" value="XM_056932907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH84"/>
    <dbReference type="GeneID" id="81623156"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000236">
        <property type="entry name" value="Cell division control protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5491738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="21530" checksum="C65FAEB278FB2B0E" modified="2023-11-08" version="1">MVVATIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGDEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVTSPASFENVREKWFPEVHHHCPGVPCLIVGTQTDLRDDASVREKLARQKMQPIRKEDGDRMAKELGAVKYVECSALTQYKLKDVFDEAIVAALEPAPKKKSRGCRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHY2</accession>
    <name>A0A9W9XHY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_001440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793074.1">
        <property type="nucleotide sequence ID" value="XM_056931043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHY2"/>
    <dbReference type="GeneID" id="81621292"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF18">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5492694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="34703" checksum="F05B75A17383FF38" modified="2023-11-08" version="1">MRKVDFLHTFARSQKITNLGIISPSICYLDRELFIYCIHQMWRLFCQQISKVTLVRHSLEQLAGRTVLTTFRENEQTTIFAPLLGNGIFTQEGLAWKHSRELLRKQFIRVQYQNLDHFREHVDNLINRLPSSGVVDLQPLFFDLTLDTATALLFGRSVYSLRAGIDQHKENKLFAESFNIAQEGLAKRFRIAPWHFLYNPPAFRKACANVHQFVERYIKDLDLENAERHEMKQSGFIKQIAEESTSVKELRDQLLNVLLAGRDTTACCLSWTLYVLGSELASKPALTSPFWSSVDSLFVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLD8</accession>
    <name>A0A9W9XLD8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_000283</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ORC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794180.1">
        <property type="nucleotide sequence ID" value="XM_056929887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLD8"/>
    <dbReference type="GeneID" id="81620136"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="7">
        <location>
            <begin position="361"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="8">
        <location>
            <begin position="615"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5495167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="685" mass="76222" checksum="7E21E4275F4D376A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLI5</accession>
    <name>A0A9W9XLI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794209.1">
        <property type="nucleotide sequence ID" value="XM_056929916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLI5"/>
    <dbReference type="GeneID" id="81620165"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="75"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="167" mass="18421" checksum="21D3313078449EEB" modified="2023-11-08" version="1">MVQQLSLSNEEEVALAQISGYRFKNKRLLETAIQSRGSNFLWQGNERLSVVGQTTLTMCIELIGCATGRDKGEQPTITDIGMDTSRQELASRERLIQLGRTLGLAKFIRLGNSCPGTVAPRQMLSAVQALIAAIYLDSSMDLQQTMHALNHMGLISGTYDQVLRYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM21</accession>
    <name>A0A9W9XM21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Endo-beta-1,4-mannanase F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_000599</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Has endoglucanase activity on substrates containing beta-1,4 glycosidic bonds, like in carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC) and beta-glucan. Involved in the degradation of complex natural cellulosic substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794496.1">
        <property type="nucleotide sequence ID" value="XM_056930203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XM21"/>
    <dbReference type="GeneID" id="81620452"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000078">
        <property type="entry name" value="Endo-beta-1,4-glucanase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF1">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040973726" description="cellulase" evidence="11">
        <location>
            <begin position="17"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="12">
        <location>
            <begin position="374"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="334"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5495483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="410" mass="43886" checksum="F136DED78FE5BF72" modified="2023-11-08" version="1">MRYDLLLAASATLALAVPQGISKRAPGFVWFGASESVAEFGQGKLPGVLGTDYYWPDHSAIQTLYDGGMNIFRVPFLMERLIPNSMTASPDAAYLKGLTDTINFITSLGAHAIVDPHNYGRYYGQVITSTSDFKAFWTTVAKQFASNDKVIFDTNNEFNTEDQSTVYDMNQAAIDAIRAAGATSQYIFVEGNSWTGAWTWVSVNSGLANLTDPQNKIVYEMHQYLDSDGSGTSGTCASSTIGKERVTSATQWLKDNNKLGFLGEFAGGANSVCESAITGMLDYMQANSDVWLGASWWAAGPWWGNYFASMEPPSGAGYTYYYKILSNYFPGKSTGGGSTTTTTTAPATTTTKAPVTTTTTTTTAPATTTATGGATAAHWAQCGGVGYSGPTVCASPYTCKVQNDYYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMF0</accession>
    <name>A0A9W9XMF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate cyclase</fullName>
            <ecNumber evidence="5">4.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATP pyrophosphate-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">N7539_000827</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794724.1">
        <property type="nucleotide sequence ID" value="XM_056930431.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81620680"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17214">
        <property type="entry name" value="RA_CYR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000055">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000220">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000305">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000580">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013716">
        <property type="entry name" value="Adenylate_cyclase_G-a-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055071">
        <property type="entry name" value="RA_PHLPP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08509">
        <property type="entry name" value="Ad_cyc_g-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23010">
        <property type="entry name" value="RA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ras-associating" evidence="19">
        <location>
            <begin position="567"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="20">
        <location>
            <begin position="1356"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="1693"/>
            <end position="1830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1048"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2064"/>
            <end position="2083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="371"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="428"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1110"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1126"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ5495711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="2115" mass="234079" checksum="EBB2C0882A419B00" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMF1</accession>
    <name>A0A9W9XMF1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793972.1">
        <property type="nucleotide sequence ID" value="XM_056929679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMF1"/>
    <dbReference type="GeneID" id="81619928"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5494959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="263" mass="29125" checksum="82CE34BE29F9F8B3" modified="2023-11-08" version="1">MGFIASMTRYVGGKSSSRKSSTAHPQRHFDDDSNELIQTSSHTASLVPTESIASTSTMAFSSSGEATTSTSSMHGDHHGNGTWDINIRTLFDEVDTLDPATSRAIKALSLPDHPVLKMETTKTPSATTPKNSIQTAIHADSKDDTVSTQGSKAERSSRLRMSWDRAWYREPPTSEVRTRTRLRRSMTGFLKKRSVKSPSQPASSLGTAQSPPSTPRWIDAARYMEKDIADEKDEFDWLEENGPRRSENENAKLWAGELIGRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMS8</accession>
    <name>A0A9W9XMS8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">RecQ-like DNA helicase BLM</fullName>
            <ecNumber evidence="17">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">N7539_000970</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="17"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794867.1">
        <property type="nucleotide sequence ID" value="XM_056930574.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81620823"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000537">
        <property type="entry name" value="Bloom syndrome RecQ-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000340">
        <property type="entry name" value="Bloom syndrome, RecQ helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="21">
        <location>
            <begin position="634"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="22">
        <location>
            <begin position="845"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="20">
        <location>
            <begin position="1248"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="70"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="173"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="293"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1143"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1335"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1385"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="502"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="1152"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1167"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1186"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="1413"/>
            <end position="1427"/>
        </location>
    </feature>
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            <begin position="1448"/>
            <end position="1457"/>
        </location>
    </feature>
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        <location>
            <begin position="1467"/>
            <end position="1477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00073450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAJ5495854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1477" mass="164592" checksum="B2813C24CBF886B6" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XNA3</accession>
    <name>A0A9W9XNA3_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">N7539_001258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
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        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5496142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="279" mass="30165" checksum="653456C31D716B6B" modified="2023-11-08" version="1">MSPSQAFPIDKSSVPATAAHSSKPPPPPARNPKNARSSNTNVTSEGPAYGDLPGVEKNANEVKCNGTVVFSWAGDTLDTIDFDFLRTNDDNLKGTVTLRQVVTNYAGSGQSRKVAAERLYRSLGRLRCLDHAIVRYNAGLRSQTSEFFQYWRRHTLSLLSGSNGDLATIEVIGLTELINQVEEIAGPVIRAARELISNGMLSFDGLGELFRPGIPVKCTSVPGCGPCIRAVVRHGTASSASDLERRLCDVLELCAEWDALAVLDEADVFLETRSTSDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XPA7</accession>
    <name>A0A9W9XPA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vacuolar iron transporter cccA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_001216</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
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    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_056930820.1"/>
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    <dbReference type="GeneID" id="81621069"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02435">
        <property type="entry name" value="CCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5496100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="300" mass="31747" checksum="9D825C177DBFBF18" modified="2023-11-08" version="1">MALLFLRKKLFPAPEQDKIHSKPLLGRTDDQDTIRGDAGADLESQRSYDTFGRCVSHDGSTGSGSQRSRINPRIISDAILGLSDGLTVPFALSAGLSALGNTKVVVLGGLAELAAGAISMGLGGYVGAKSEAESYEATVRETKELIDSDPSATYNIVRDTFTPFGLSPSVIDEITRDLHASYDRLLEFLLTFHHGESAPDCNQAWISALTLAVGYFVGGFIPLIPYFIASQVLVALYWSIGVMGVTLLVFGYVKTCVVRGWTGRDNVVAAIWGGVQMVFVGGVAAGAAIALVRLIDTGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XPE7</accession>
    <name>A0A9W9XPE7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SNF2 family helicase/ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_001065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794962.1">
        <property type="nucleotide sequence ID" value="XM_056930669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XPE7"/>
    <dbReference type="GeneID" id="81620918"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000053">
        <property type="entry name" value="SNF2 family helicase/ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF14">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="388"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="938"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="228"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="626"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="796"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1124"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="321"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="798"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="828"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="869"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="909"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1158"/>
            <end position="1169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5495949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1169" mass="130424" checksum="3FD1DE2E10110CBA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XPF9</accession>
    <name>A0A9W9XPF9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tetratricopeptide-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_001080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SNAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794977.1">
        <property type="nucleotide sequence ID" value="XM_056930684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XPF9"/>
    <dbReference type="GeneID" id="81620933"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000049">
        <property type="entry name" value="Alpha-soluble NSF attachment protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5495964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="332" mass="37280" checksum="8DB1264FE5479EA6" modified="2023-11-08" version="1">MAQDPRALLQKADKALSGASGGFSWFGGRAEKYENAADLFTQAANAFRVQKMSKRVLPPPAQNRPRLPADPRRVAIPPSSLKIILNESFHATDKEAGQAFEKAAAIQTQNLNEPDDAANTLQEAFKVYRKSDPEDAARVLTSAINHYVLRGNLRRAATQQQYLAELYEAEVGDMKKALEAYEKAAEWFEGDNAEALANKHYLKVADLAALEGDYYKSITNYERIARQSIANNLMKWSVKDYLLKAGICHLATKDMVEATRALETYREIDPSFSSTREHQLLVDLLQAVEGGDQEAFADKLFQFDQLSKLDKWKTTLLLRVKNNIEEAEEDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ81</accession>
    <name>A0A9X0BJ81_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_009376</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785693.1">
        <property type="nucleotide sequence ID" value="XM_056938971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJ81"/>
    <dbReference type="GeneID" id="81629221"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000032">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
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</entry>
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</entry>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:fungal-type cell wall organization"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
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        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF2">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="24560" checksum="2E8B7035EAE57CA8" modified="2023-11-08" version="1">MKVNLSDFPTVGKLDLRRSFSISSADVSGLADTATTEATKTTNSAADSISQASAAVGTVANQAQSRIESIASELKVNLPAYYSVGLWDYCQGKTVGGRPSNCTRPSASFSFNLLDISKYVSPEFNDLFPSKDTKGLTGSLKLSKFAISAYIVGISTTACALVVGLVTTFREAKSRWLKVLQILSSAIALASILIASAVVTAIYTALTGAVEVVLGSFGAHASLGVQRALQDCLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BLQ3</accession>
    <name>A0A9X0BLQ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786542.1">
        <property type="nucleotide sequence ID" value="XM_056938160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BLQ3"/>
    <dbReference type="GeneID" id="81628410"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF1">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="1">
        <location>
            <begin position="99"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="242" mass="27455" checksum="053E83D9D7B952E2" modified="2023-11-08" version="1">MERFSVRRIDGGIIQISNPMFQVQNPIWKPHVKYQEYWQLVKTQPNGPIETYLCSYIVDWSNQTARNFRELIAQPMQVFDQKHLLWQNSKTCKHLAALVQDVLGTKTVKKVLCFGLGDFCRSAPEWLKKQHDSWDENSEVKNVMGCMIQHSMALTIAQLCRGNETLPLLAQDPEYTEVAEDILTKKEFEIVGTHGAGGFAEIDEDSIVISPFAAAPVKQIIADLARPVLIISTGFEVFNSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BLZ7</accession>
    <name>A0A9X0BLZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_008745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786348.1">
        <property type="nucleotide sequence ID" value="XM_056938340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BLZ7"/>
    <dbReference type="GeneID" id="81628590"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="4">
        <location>
            <begin position="37"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="3">
        <location>
            <begin position="608"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5471802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="708" mass="79963" checksum="EA54972666E4F74E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BN56</accession>
    <name>A0A9X0BN56_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787088.1">
        <property type="nucleotide sequence ID" value="XM_056937996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BN56"/>
    <dbReference type="GeneID" id="81628246"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5475330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21347" checksum="28C9D422247CE6C6" modified="2023-11-08" version="1">MDRPSKDAFQTGWICALPIEAAAAHEMLDVKFGILDEQDSADSNTYMLGRIWQTQRCEYGTTSATVVANNMLRTFSNSLRIGLMVGIGGGIPSAAHDIRLGDVIFSYPDATCGGVIHYDRGKIIAGGEFQRTGSLNSPPRALLTAVNIMRAASLTDDPSYLGYIQSTIERNARTRKNFGRPPSQPDRLFLEYVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNC0</accession>
    <name>A0A9X0BNC0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786971.1">
        <property type="nucleotide sequence ID" value="XM_056937879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNC0"/>
    <dbReference type="GeneID" id="81628129"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="363" mass="39464" checksum="D6B247CE686A11F1" modified="2023-11-08" version="1">MVVASLGLQQPSTGATGYIGGDALSVIHDAHPDYSYVALVRSAEKADQVKSRFPNVQTVMGDLDDSALLKRESAAADIVLHTADASDHEGAAKSIAAGLVAGHSPDKPGYWLHTGGTGILTFEDSDKESFGNKSDKVYNDWDGVNELLTLPDHAFHRNVDKIVLEAAEKHADVLRVALVCPPTIYGTTRTYRPMPLAFGAGRGRGPSSQRGRQVYELANVTLRLQKGPVIGKGDAIWNNVHVHDLSTVYSLLVEAAVAGRTDKGLWGPEAYYLTENGEHRWGDLAQATAQTAAEQGFIPEAKAERIDLESAKKYAGFESLSWGMNSRGRALRAREILGWRPSSPSLLEELPEIVRSEWQRLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNF6</accession>
    <name>A0A9X0BNF6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_008218</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786910.1">
        <property type="nucleotide sequence ID" value="XM_056937818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNF6"/>
    <dbReference type="GeneID" id="81628068"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000019">
        <property type="entry name" value="RNA exonuclease NEF-sp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="337"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="603"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="619"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5475152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="723" mass="79898" checksum="EB0CE02D8A44428D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNG5</accession>
    <name>A0A9X0BNG5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786940.1">
        <property type="nucleotide sequence ID" value="XM_056937848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNG5"/>
    <dbReference type="GeneID" id="81628098"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF2">
        <property type="entry name" value="RESISTANCE PROTEIN ARS2, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="666"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
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</entry>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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        </location>
    </feature>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5477395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="200" mass="22507" checksum="4FFDC24E7B3A6E8E" modified="2023-11-08" version="1">MSQLNPSALTRLIESQSASDDPQAATTIQILHNLQHQHLWTSLQTHDIVTTSDSTVENPQDTPRTLISGIPPHRVYTHPDEQLYMLEKSITEDDLQPERMFVIPTAQGQKWSLRRMAVAFDALASLENTVTEDAEVARGSADSGKVEKLDEYYEKKREAQVTKAWGTRRALLAMTNRDMGGDGTVVYYIVQEGEVKPRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSK3</accession>
    <name>A0A9X0BSK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788141.1">
        <property type="nucleotide sequence ID" value="XM_056936206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSK3"/>
    <dbReference type="GeneID" id="81626455"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5480711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="440" mass="48744" checksum="F8855D5EE2E853CA" modified="2023-11-08" version="1">MYLPRKRELSRKNSVFIICVSVLISLIILSVCSYSVARWLRVRYSEPKYLPGHILKRQWRQWRPGNSSYGQVPTHGQANGHDTSYRGAGQSGPEMTSRSSGNARNNNHNDSNNGPQRETSIRSVMTLPAYSASPKPTEQVIAREGERAGMDMVVEFPETAEEEESRREDQMEALYQLRVQRRYQLAVREARRRERREARARGESIRLDELRQDLRDRGINSSSAASSIIAEYRARERERRIASVSYADLGHVRHDGTRLRADSHNSDSDQRPLLQNADMQESSPSLTTVPTTRSQVQSFASTVSVDADSLALRPVSTHASSVRPVAAVVEEGDLGTFELPPPGYDQLDWGEAPAYEGPINQSAREIRLPEITRLPSIHINLASPISNSPATPTPVEDVVSQQPNLASGNTAVEAEVSPETAASRDVTAESSDRPSAGPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSW4</accession>
    <name>A0A9X0BSW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glucose transporter HXT5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_007071</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788607.1">
        <property type="nucleotide sequence ID" value="XM_056936672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSW4"/>
    <dbReference type="GeneID" id="81626921"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="63"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="530"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="547"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5481177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="560" mass="61998" checksum="5207373E7A4A0BA4" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BU26</accession>
    <name>A0A9X0BU26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bis(5'-adenosyl)-triphosphatase</fullName>
            <ecNumber evidence="6">3.6.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_005872</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = AMP + ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13893"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.29" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789346.1">
        <property type="nucleotide sequence ID" value="XM_056935474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BU26"/>
    <dbReference type="GeneID" id="81625723"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047710">
        <property type="term" value="F:bis(5'-adenosyl)-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051884">
        <property type="entry name" value="Bis(5'-adenosyl)-TPase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243:SF1">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="8">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="5">
        <location>
            <begin position="101"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="2">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="96"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for induction of apoptosis" evidence="4">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5484076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="190" mass="21188" checksum="C5C2D0E4602D8BE1" modified="2023-11-08" version="1">MSSVRSASAPIYFGSFLVTPQVFHQTAHSFALVNLKPILPGHVLISPRRVVPRVSDLTPAETSDLFLTVRRVGRMIERYYGAASLNIAVQDGVHAGQSVPHVHAHIIPRKPADLDPMDAVYDMLDGEEGDVGKAYREAQTDCPSEHERTSTRSRSRFPAVDNEERKPRTAEEMKAEADSLRREMDKEPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BU69</accession>
    <name>A0A9X0BU69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789643.1">
        <property type="nucleotide sequence ID" value="XM_056934449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BU69"/>
    <dbReference type="GeneID" id="81624698"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5484859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="92" mass="9985" checksum="950C30D927CC0BB0" modified="2023-11-08" version="1">MDIYCGSTGFVTIPAQQIKSLVAFQALSHAISHVARMTYFPESPSFSKITDEYLDGYKTVPPTITSRELSADRCHADGPRTAEKNVAATDCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUF2</accession>
    <name>A0A9X0BUF2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_004835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789631.1">
        <property type="nucleotide sequence ID" value="XM_056934437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUF2"/>
    <dbReference type="GeneID" id="81624686"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF15">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="40"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="7">
        <location>
            <begin position="478"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5484847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="663" mass="73309" checksum="77812C48924C668F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXC7</accession>
    <name>A0A9X0BXC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_003541</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790684.1">
        <property type="nucleotide sequence ID" value="XM_056933143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXC7"/>
    <dbReference type="GeneID" id="81623392"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DCUN1" evidence="3">
        <location>
            <begin position="59"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5488651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="270" mass="30979" checksum="5CF541D5D8E7FFFB" modified="2023-11-08" version="1">MPPATASQKQSIAQFVALTDCTDSVASKFLRAAHWNIDRAIDRYKSTQVYCHLSPALTTFRANMNLAFKDESNEEAAVISIEGAIRFLEDINVQLDEVTCLGVMELCKCPTMGEFPRESFVAGWKETKCDTLPKMAEYANQLRSRIPTDKDLFRRVYCHTFPISRMAGQRNLPYDLAAEQWRLLFTADRGGVPWSTASTPWLEWWLEFLEERGKKAVSKDLWQQLELFVRKTKEDESFGWWSVDAAWPGTLDDFVGWVQEKRAQGNAMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXZ5</accession>
    <name>A0A9X0BXZ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoside diphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003738</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790881.1">
        <property type="nucleotide sequence ID" value="XM_056933340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXZ5"/>
    <dbReference type="GeneID" id="81623589"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046036">
        <property type="term" value="P:CTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006256">
        <property type="term" value="P:UDP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24039">
        <property type="entry name" value="ASKHA_NBD_YND1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF121">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATASE MIG-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="628"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="705"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="719"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="215"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5488848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="748" mass="82473" checksum="6F6C80CF99A4D611" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY31</accession>
    <name>A0A9X0BY31_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF92 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003677</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790820.1">
        <property type="nucleotide sequence ID" value="XM_056933279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BY31"/>
    <dbReference type="GeneID" id="81623528"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5488787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="37868" checksum="3B446AA7DCB30D4C" modified="2023-11-08" version="1">MSVSPIRLLVVVGMVYRAWSRRSLTPLGLVVAGTSGIAQALHPWATPLTLLLVFYLGGTKATKVKHDIKARKTLSATGSQGGEGARNHLQVLANSVVATCLSIAHTVYFLRNPSAASCFSFGHHPADILMVGIVANYAAVAADTYSSELGILAKSNPRLITSLTLREVPPGTNGGVTAAGLGAGLLGAFSIALTSAIILPSCSNGPQIQARVIWTLAITLWGLLGSILDSVLGGLLQASVVDKRSGKIVEGSGGRKVLIHPGSTSRATNSGDGLVTQQSGAAGAHIRKTEAVANAATLHGSRATSGTSASTGSKEEEHAHESRRIESGRDWLDNNGVNVLMAFLMSVGAMGAAQQLWGVDAWDLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY36</accession>
    <name>A0A9X0BY36_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_003692</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790835.1">
        <property type="nucleotide sequence ID" value="XM_056933294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BY36"/>
    <dbReference type="GeneID" id="81623543"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF382">
        <property type="entry name" value="LOW-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5488802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="464" mass="50521" checksum="5833DC9134A02727" modified="2023-11-08" version="1">MDDAFWAGEKENDIFEGLISLAELSTVGLVQPFFPCRPLLPRAREALAPALIFWLIGFIQSFCGFCIWLELGSVLPRSGGEKACLEAAYLRPPLLATTIFAVHVVVPGFTGIGSIMAAENILLAVHGTANDWIKRSIVVALVVGVASLHIFGKNLSIRIMVDVPHPGGSFAHPFAGSSTTYVMDEIKDPKRTLKWAGILEAGSVGLLYLLVNVAYFTVATPQELSETGVTVVALLVGRAFGPRMQWLAAFLAALSSLGNLMTASFPILRVIQGLTTEGVVPFPSFFASRTSSGRPAASTFLLVFLPSVLMVTLMPLCYVSTHRHDDLSHLLIRATEDTYNSLLDVGQYAMAIILFFVVAGFFIIRNRVAYPPRTFKVWSSVAHIYLAVQSFLVILPLAGSGKSDTHLPSWLTPVGGLLTVGFSCVYWSYLWYILPKIGNIIWQKRISTCSDGAAAVVCERRYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY38</accession>
    <name>A0A9X0BY38_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Cutinase</fullName>
            <ecNumber evidence="3 12">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_003873</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cutinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3 12"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791016.1">
        <property type="nucleotide sequence ID" value="XM_056933475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BY38"/>
    <dbReference type="GeneID" id="81623724"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000235">
        <property type="entry name" value="Cutinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043579">
        <property type="entry name" value="CUTINASE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF3">
        <property type="entry name" value="CUTINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00931">
        <property type="entry name" value="CUTINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 12" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041016960" description="Cutinase" evidence="12">
        <location>
            <begin position="17"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="185"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5488983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="223" mass="23220" checksum="2AD1E8F1C0517118" modified="2023-11-08" version="1">MKFSLLALALAGLGAATPVTLIQRQSRDFHLGSRIHRAGVDGNYPSKQIPLRSPPVLTSSQQGQSVGPAVCSGLKSARSSGVACQGVGPQYTADLPSNALPDNTSPQAIDEAIGLFKQAVQKCPNTQIVAGGYSQGTAVIDGAISRLPDNVKEKIKGVALFGYTRNLQEHGQISNFPKDPVKVYCAVGDLVCSGTLIITAAHFTYVANAADATQFLVSKLASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYY5</accession>
    <name>A0A9X0BYY5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sas10 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002782</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792344.1">
        <property type="nucleotide sequence ID" value="XM_056932385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYY5"/>
    <dbReference type="GeneID" id="81622634"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF8">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="7">
        <location>
            <begin position="563"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="573"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5491215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="637" mass="71595" checksum="1FDAAD6CB447AAE2" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZC9</accession>
    <name>A0A9X0BZC9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinetochore protein fta4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792166.1">
        <property type="nucleotide sequence ID" value="XM_056932207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZC9"/>
    <dbReference type="GeneID" id="81622456"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025207">
        <property type="entry name" value="Sim4_Fta4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42040">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42040:SF1">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13093">
        <property type="entry name" value="FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="146"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="29651" checksum="F52CD29FAA8C4E1A" modified="2023-11-08" version="1">MDSSRTISEAKSAFLRTQVRILSETLAPPDDWKNYAVETEDGDLPEKVISDVLHKVNVATKQHHRVVYSSQAIHHVAQQIASLYWSSVNQETPSRTPFTEGVEKSTDLSRHMLPILWPRSTVFRILLTIRRNLIKVPHDVESLGASDDTNARYQQLRERLQTLDERRQQRQQRLDQLRHLQRLLDPFKDAQKNIQPNLVTRDGELIQELERMRMLAARVGGRISQQKQKIRLDDGERSDYLLPGSSSRLDSLLDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZX2</accession>
    <name>A0A9X0BZX2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial ribosomal protein subunit L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_001713</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793347.1">
        <property type="nucleotide sequence ID" value="XM_056931316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZX2"/>
    <dbReference type="GeneID" id="81621565"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000017">
        <property type="entry name" value="54S ribosomal protein L22, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047867">
        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5492967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="38821" checksum="F1AA44E5160AC95A" modified="2023-11-08" version="1">MSAMGAVSPYGQMVRSVARSHLFYAARRNFASTTVCEAQNDNGNANSNKKKSGFLSSVKDWVLGESKPKAAFTPMAPKREEGGLGASSIFADDVGQTSGPKPSKQKKQLQEQQPGQEEEALPLEMRDKNRMQLALNPNPQAQMRWEKKMITSQIRKRGRVSKEVQIKRTERESLSKSHWFKTSVKKLGPLARQIAGKPLDEAILQMRFSKKKAAKDVLGHLEHAKNVATVRAGMGLGLPTGTSAEPVTVTLKSGERKKITDPTSIYVQQAWVNRGPYGFGMDHRARGQINRLRPPTAGLSLVLKEEKTRIREWQQREADALRKRKAQLWTQLPDRKISAQNQYYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZZ8</accession>
    <name>A0A9X0BZZ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_001341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792975.1">
        <property type="nucleotide sequence ID" value="XM_056930944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZZ8"/>
    <dbReference type="GeneID" id="81621193"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5492595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="46712" checksum="FBBAEA29B2DE5A4A" modified="2023-11-08" version="1">MATTSTIYLPAEIRLMVVGHLLADDAYDANDRGMHERQRDLWNLCLVSFGWYEAAIKALYVAPQLWRGNKFTLFMKTVCPSRAIQNQQRRGHIRTPDFGSWVEDLNMSRLVHQSSNSQTARLLGNVKKSLTSFTAPQMGIAVNCLGIIAKCQRLKHLDMSLVPGSVFGFPRLKQLVHKLPELQTLHLPRSMALTRTTQEDGRWPSKLSTMSLGGSMDAELMLDFEWPPSLSRLVLRHCISFDTPVMEDLLSHDHLCTHLQALTLGRSNLEMFENGMGSEILYELQQLTYLKLPWDLLPYLFMVPPNVPDVADEEGELPILPLRVLEITKEYFSDHDAELDFSFALSRALDENLRNLLALGIERSCRPLLESRFQELDVKIWDHVSSIPDSELMNSGIDDLGIYFIEEDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C009</accession>
    <name>A0A9X0C009_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hypervirulence associated protein TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793201.1">
        <property type="nucleotide sequence ID" value="XM_056931170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C009"/>
    <dbReference type="GeneID" id="81621419"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021331">
        <property type="entry name" value="Hva1_TUDOR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11160">
        <property type="entry name" value="Hva1_TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hypervirulence associated protein TUDOR" evidence="2">
        <location>
            <begin position="7"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5492821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="79" mass="8794" checksum="47FBD7021702D6CE" modified="2023-11-08" version="1">MPAFQTGQRVSYKPVGGRESHTSESVGVIRDVSTHDTTMTGRRVEASPGEPRYEVCPPSFPSPHVHEIQFLVDRETILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C065</accession>
    <name>A0A9X0C065_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7820 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793632.1">
        <property type="nucleotide sequence ID" value="XM_056931601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C065"/>
    <dbReference type="GeneID" id="81621850"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056722">
        <property type="entry name" value="DUF7820"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42078">
        <property type="entry name" value="GLUCAN 1, 4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42078:SF1">
        <property type="entry name" value="GLUCAN 1, 4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25130">
        <property type="entry name" value="DUF7820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7820" evidence="2">
        <location>
            <begin position="408"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5493252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="704" mass="75847" checksum="5765F460C956DAF1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0Q2</accession>
    <name>A0A9X0C0Q2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA polymerase alpha-associated DNA helicase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_002106</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793740.1">
        <property type="nucleotide sequence ID" value="XM_056931709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0Q2"/>
    <dbReference type="GeneID" id="81621958"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18044">
        <property type="entry name" value="DEXXQc_SMUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.270:FF:000006">
        <property type="entry name" value="Similar to DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="240"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="258"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5493360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="716" mass="78662" checksum="F8B3AEABA9B983E0" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C1X9</accession>
    <name>A0A9X0C1X9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxyphenylpyruvate dioxygenase</fullName>
            <ecNumber evidence="8">1.13.11.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">4-hydroxyphenylpyruvic acid oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">N7539_000138</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>3-(4-hydroxyphenyl)pyruvate + O2 = homogentisate + CO2</text>
            <dbReference type="Rhea" id="RHEA:16189"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="EC" id="1.13.11.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:16190"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the 4HPPD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.27" evidence="8"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794035.1">
        <property type="nucleotide sequence ID" value="XM_056929742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C1X9"/>
    <dbReference type="GeneID" id="81619991"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000022">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF1">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15 25" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17" id="KW-0408">Iron</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="VOC" evidence="24">
        <location>
            <begin position="41"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="24">
        <location>
            <begin position="218"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="25">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="25">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00029786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAJ5495022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="368" mass="41230" checksum="6C35A91973E22171" modified="2023-11-08" version="1" fragment="single">LSSFPFLFFGITNKTYSITMGDAGIAPNRAVIHGINPNYLGFDYIGWYVGNARQTVSYFVNHYGFSVLAYWGPETGSYTTTAYVIGNGAARFVFTAPLASPDSSWDIRASEAERAFCEEVHAHLTKHGDGVKDIAFQVDDVQGVWAHAVENGAQSIREPEVLKNEDGQVVVAAISTFGDTIHTLINRSTYDGSFLPGFKTVNQPNPLQQHLPKVDVIEIDHCVGNQPWNWLESIVQYYEKALNFHRYWTVDDKEMCSDFSAMNSVVVASPNEVIKMPMSEPATGKKKSQIEEFCDYYNGAGCQHIAFRTNNIIEAVESLKRRGVDFLSVPDTYYTNVRERLKELGTEVAEDIDALQRYNILIDFTVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2F4</accession>
    <name>A0A9X0C2F4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_000125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794022.1">
        <property type="nucleotide sequence ID" value="XM_056929729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2F4"/>
    <dbReference type="GeneID" id="81619978"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061188">
        <property type="term" value="P:negative regulation of rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061186">
        <property type="term" value="P:negative regulation of silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053051">
        <property type="entry name" value="HDAC_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="103"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5495009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="610" mass="67675" checksum="9F2C528B08C262B5" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2V5</accession>
    <name>A0A9X0C2V5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_000666</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794563.1">
        <property type="nucleotide sequence ID" value="XM_056930270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2V5"/>
    <dbReference type="GeneID" id="81620519"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF177">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="45"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5495550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="520" mass="55017" checksum="D75A7039BEDA5F35" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WK99</accession>
    <name>A0A9W9WK99_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_009564</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785654.1">
        <property type="nucleotide sequence ID" value="XM_056939159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WK99"/>
    <dbReference type="GeneID" id="81629409"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12452">
        <property type="entry name" value="RRM_ARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000021">
        <property type="entry name" value="MUTL protein homolog 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000024">
        <property type="entry name" value="RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034351">
        <property type="entry name" value="Nrp1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111:SF40">
        <property type="entry name" value="RNA-BINDING PROTEIN INVOLVED IN HETEROCHROMATIN ASSEMBLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="279"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="15">
        <location>
            <begin position="378"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="15">
        <location>
            <begin position="452"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="537"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5466608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="640" mass="68646" checksum="ED856F8ACDDB09EC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLI4</accession>
    <name>A0A9W9WLI4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_009281</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786253.1">
        <property type="nucleotide sequence ID" value="XM_056938876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLI4"/>
    <dbReference type="GeneID" id="81629126"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000058">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="685"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5469663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="744" mass="81215" checksum="3AB961733F79CA52" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLM9</accession>
    <name>A0A9W9WLM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056938934.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81629184"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5469721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="307" mass="34185" checksum="3070516B569C9C62" modified="2023-11-08" version="1">MTAREVDVDLATENVMSHTVTKNADSTSLSSDDYGTNEIKYCRRHYHGRQDTATEKAVSGKNKKFELEEIFQLLWIFRAMLAFSLFETITSMTFAPNATELAEQRFKVKPITAGWIILASKYGVFGVGLTLLLSMALADLVSSRTGSPVSLDVYSVVFNLGYTATMDGTCTNLWHQSVYSSAFSLKVTMNHAIIVRIITSALQDADNNSYLQIMQVYLVLSVFTAFVGIVILLSTFMTKQLAILQWAQKKRLTSGAETSHVLKDNSLIDHDKRARYIYIVCFAAFVLLIAYIGGAVTGHTVEQRESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQP2</accession>
    <name>A0A9W9WQP2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786370.1">
        <property type="nucleotide sequence ID" value="XM_056938362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQP2"/>
    <dbReference type="GeneID" id="81628612"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5471824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="135" mass="15164" checksum="CF599D27A0F5AAF7" modified="2023-11-08" version="1">MSTASAPGTASRTVSARERALAVKKEQEDALARLHLNVLYIVLYIRTDPPRSDDFHWGYYFHTTPQGGLKYHMRNLGAGWIPDHGSTGGVFKSNFLCVLIEIGRVPPEKHSQLDQVMKSRDRDVNSIPGVTCRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQU1</accession>
    <name>A0A9W9WQU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPCPD1-like C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_008503</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786480.1">
        <property type="nucleotide sequence ID" value="XM_056938098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQU1"/>
    <dbReference type="GeneID" id="81628348"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="343"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="GPCPD1-like C2" evidence="4">
        <location>
            <begin position="429"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5471934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="634" mass="70078" checksum="7933465F2E0218AE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQW5</accession>
    <name>A0A9W9WQW5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tryptophan synthase</fullName>
            <ecNumber evidence="3">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_008601</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786578.1">
        <property type="nucleotide sequence ID" value="XM_056938196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQW5"/>
    <dbReference type="GeneID" id="81628446"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF2">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="10">
        <location>
            <begin position="62"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5472032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="383" mass="41306" checksum="6AD7095A2A0F5CDA" modified="2023-11-08" version="1">MSSVLQKYYVSPGSPPLGGRYVPELMIGFLERITIAFESAMGDNAFWKEVNGLIRLSSPQCSPLYQARKITDHIGGATLWMKREDLEHFGSHKAWNITGQLSLAKRMGCKEVVTDCASTKHGKFTALMCAHLNLKCVVIIGADDAEKQENGIHEIEKLGATVLRARCLYGAATLRTAIAEAFRYAALYYDTVYYLMGGVSGPHPIPGMTATFQQRLGAEVAKQFQVESKDQPDALVAAVGTGTGAVGLFRPFIDSAGVRLVGVESAGASPLTKGQVGVLHGAKTLVLQNDEGQILDSNCISPDLNITVVGPEVANWKINGRVEIYTATDEDARRGLEILSEYEDIKAGLDCSHAVIKAMEIAKELGPGKHVILLVTGDDEIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU00</accession>
    <name>A0A9W9WU00_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787049.1">
        <property type="nucleotide sequence ID" value="XM_056937957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WU00"/>
    <dbReference type="GeneID" id="81628207"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024526">
        <property type="entry name" value="DUF3807"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40642">
        <property type="entry name" value="YALI0F31295P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40642:SF1">
        <property type="entry name" value="YALI0F31295P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12720">
        <property type="entry name" value="DUF3807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="196" mass="22124" checksum="7A6F88B3AFB8CA62" modified="2023-11-08" version="1">MQIPTITLEDLQSFQATHFPGARSPLQPPYPEAADSVTSDTRSTEEDDLGHYPDGVKRTLTDEQIRIFRHTEVHALLRKRQLEQDDAEYEARAGKRSLDEDASVEVQDRALDSSDSPVTDTLQQRCQVSPASGKRLKRVDHEVPDQPEQSLDYEDHHDDVQSKASVPAPASALDQTQRTRQAHPTFHGRKIISYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU89</accession>
    <name>A0A9W9WU89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_008273</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786965.1">
        <property type="nucleotide sequence ID" value="XM_056937873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WU89"/>
    <dbReference type="GeneID" id="81628123"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000017">
        <property type="entry name" value="PMS1 homolog 1, mismatch repair system component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF41">
        <property type="entry name" value="MISMATCH REPAIR PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="4">
        <location>
            <begin position="227"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="430"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="494"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="602"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5475207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="879" mass="95371" checksum="3DA0ECF64A11678E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUD4</accession>
    <name>A0A9W9WUD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_007988</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787454.1">
        <property type="nucleotide sequence ID" value="XM_056937589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUD4"/>
    <dbReference type="GeneID" id="81627838"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="242"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5475701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="473" mass="51331" checksum="ADB627C7CA186792" modified="2023-11-08" version="1">MELEPSCSQRAIESGSLTTRPDHEIHTFDETPPNGGYGWICTFCVFVIIMHTWGVNSAWGVILAHFLSHSTFQSASRIEFAFIGGLSISQALLIGPIVTKMQKALGTRVTLLVGTTLVFGALYGAAYATEIWHLALSQGICFGMGMGFLYIPAMSVLPQWFTTHRSLSMGIAGSGAGIGGITYNLVTGHVIGTLGVRTAYKVLAFCTLGANLVSSLLLKTRDGPRQSRQKRAFDFHDFRCPEVLLVVFWGMTTEFGYIALIYSLPNYASSIGLSTKQGSITAATLNLGLTIGRPLVGYVSDRFGRITMPAIMTAFCGAVCLMIWIPAQSYPVLLLFALLSGMVCGTFWGTVTPVLAEVVGLWRMSSSFSLICLTLVAPTTVAEPIALSLLRRAFKASRSNPRHLMGPETAVDDKQQWELLRDQGRLQAGRLMFVVTEDQLVAVAREKNISGEAGLGDDSIIVVVWLDRARQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUG4</accession>
    <name>A0A9W9WUG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787480.1">
        <property type="nucleotide sequence ID" value="XM_056937615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUG4"/>
    <dbReference type="GeneID" id="81627864"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G00100)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="2"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5475727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="262" mass="28198" checksum="A5F35E1C740AFA09" modified="2023-11-08" version="1">MTDSISVATCAIYAVFAIPVLYLLVRHGRFGLLGWLFLFLFCTIRIVGGALAVKDHSSIAANTISSVGLSPLLLATAGLLHEAREYRIQHIDQKLEWVAVLAYHMLVVAGVALTAAGSVKLQQHQAPNDKAENIVKAGISILVVAWGVLVGWTGLSFLAPRGRTSQLAKAGTILLSAIAFSLVFIGVRVFYSLVALCTQKRSLNPITGSLTIRVVLSFLPEIIVTVVYILAGCQTQGAAHLVNDREEAHSSDSQKRRAEAWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUG7</accession>
    <name>A0A9W9WUG7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 13">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="8 13">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_008393</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; pentose phosphate pathway; D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 13">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="8 13"/>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787085.1">
        <property type="nucleotide sequence ID" value="XM_056937993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUG7"/>
    <dbReference type="GeneID" id="81628243"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
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        </location>
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    </evidence>
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        <source>
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</entry>
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    <name>A0A9W9WUV6_9EURO</name>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787709.1">
        <property type="nucleotide sequence ID" value="XM_056936910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUV6"/>
    <dbReference type="GeneID" id="81627159"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="745" mass="83594" checksum="355B99B3633EC029" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV35</accession>
    <name>A0A9W9WV35_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_007395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787795.1">
        <property type="nucleotide sequence ID" value="XM_056936996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV35"/>
    <dbReference type="GeneID" id="81627245"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000014">
        <property type="entry name" value="Proteasome subunit beta type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5477251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="273" mass="30290" checksum="42EA4B8C525513A6" modified="2023-11-08" version="1">MDHFPGTWGRPRNDVYGAYDPSYLQSTGPKTHTSSPAVTGTSVVGVVFNGGVVIATDNLASLTPSFLLPLRTASYGSLARFTDTKRLRVFGDQAVVGFGGDVSDMQYIDRLLESIDIRENYSSHGNTLNAKNLHTYLAKVFYKRRSEFNPLWNHVLVAGFDSAGKPFLSSADLLGTTFSAPHLATGFGAHLAVPILRRLFPEERPVEEISQEEAVEALKQCMKVLFYRDARSTDKYSIAVITKDKIDLKEDEQLEKQSWAFAEKIKGYGRQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV89</accession>
    <name>A0A9W9WV89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_007989</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787455.1">
        <property type="nucleotide sequence ID" value="XM_056937590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV89"/>
    <dbReference type="GeneID" id="81627839"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF5">
        <property type="entry name" value="ISOCHORISMATASE FAMILY PROTEIN FAMILY (AFU_ORTHOLOGUE AFUA_3G14500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="441"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5475702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="806" mass="89472" checksum="0117E4EB7747B339" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WW71</accession>
    <name>A0A9W9WW71_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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            <authorList>
                <person name="Petersen C."/>
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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            </authorList>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        </submittedName>
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    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480960.1"/>
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    </dbReference>
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    <dbReference type="GeneID" id="81626704"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAJ5480960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        </subcellularLocation>
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    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
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            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5480932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1184" mass="135150" checksum="166BB6FADB538561" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2J8</accession>
    <name>A0A9W9X2J8_9EURO</name>
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        <recommendedName>
            <fullName evidence="5">Non-canonical purine NTP pyrophosphatase</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">N7539_006173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
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            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
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                <person name="Frisvad J.C."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAM1 NTPase family.</text>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_056935775.1"/>
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    <dbReference type="GeneID" id="81626024"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5482727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23755" checksum="42B840022E0C382C" modified="2023-11-08" version="1">MKACTFVTGNPNKVIEVNAILGNTIPIRTVALDLPEIQGSLEEIARDKCRRATMIVHPISLLWPQKTRNWKKDRPQANSITLGSFKVNGPVTVEDSALEFHAMGKLPGPYIKYFLETLGNDGLNTLLAPYEDKGADAEDYVYENLRSSSRVGSYLEFYNSVANRESGKGKIVPARGPPVFGWEPIFEFEGETLAEMAHEKKVCHVDYADSVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2K6</accession>
    <name>A0A9W9X2K6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Centrin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_006188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056935790.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81626039"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
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            <end position="226"/>
        </location>
    </feature>
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    </feature>
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            <end position="172"/>
        </location>
    </feature>
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            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
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            <end position="68"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5482742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="259" mass="28676" checksum="41CED0381E05BD19" modified="2023-11-08" version="1">MASGQPFASRSYAGAKLPERSVNQNAMPFSASSFSRHRGLGNAAPADFGGPDGPKQAQQVNNAPAAAQSHGAGQDANPLSRLTEEQREEINEAFTLFDLDRDRHLDYHELRVAFRALGFTLTKQELISLLTTYGVPRPQVQQQQQQQQQQSSNPQQQSKLNAGSNPQHPSNLLMPLSSFQAVTALKILERDPRDEILRAFELFDEGGKGFIDLEDLRRVARELGETGLEEEELRAMIEEFDLEGVGGVTREAFVGICWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2N9</accession>
    <name>A0A9W9X2N9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056935811.1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5482763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="196" mass="21926" checksum="50F12C43FAC297A3" modified="2023-11-08" version="1">MIRPLFAAVSSARCACPVSTTARQTPIATLLTPRIQNNLHISATIAQSAPAAMSRQFTSSALRSSSPFRLSSDKNESYQNPNDEYYSPYKPKRQWPPDMSKLSPKHQFRLERKYRRRAALKYARPKFIKTVTLAQWVIIGFVVVYAVLFMNWDTKDTPFDGIREAVFSGVKSVFSSPPPPGPVKRANDGTVAGSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2W9</accession>
    <name>A0A9W9X2W9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPIN90/Ldb17 leucine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788854.1">
        <property type="nucleotide sequence ID" value="XM_056935930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2W9"/>
    <dbReference type="GeneID" id="81626179"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357:SF1">
        <property type="entry name" value="NCK-INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="SPIN90_LRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN90/Ldb17 leucine-rich" evidence="2">
        <location>
            <begin position="154"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="547"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="647"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5482882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="779" mass="85258" checksum="36F15D21976D16A7" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3D4</accession>
    <name>A0A9W9X3D4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
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    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="459" mass="46916" checksum="CCC6669F36F06C54" modified="2023-11-08" version="1">MFTLPLILAAGSLPLISGAPVTYTHGHSHFHARAVDIAQVNEIASSHSLAGRSSNLYASVFGGNGQVSDGWPAMSSWVSSFDDLFEANKAIMGSSCSQWGVADTTESEMAEMKSAINKIAGESGVDARFILAIIMQESNGCVRVHTTNNGVVNPGLMQSHNGKGSCNTGINAPENVQNPCPASEIEQMIRDGTMGTADGDGLQQLLAQNGGAQDVTAYYKAARCYNSGSIAPNGNLGAGIATHCYASDIANRLLGWAAGTSSCNDNTIGSLTGSNWSGGSSSGSSGSGSGSTTTAAVNPTGVTTILPEPPAATSTSTSTSTSVAVPTIVTSAGNSNPAPTSDPALTSTVTIAPVPTAPTVSVAPAAPSSISNTISSSAQTSTSSSSSATITTNPTTPEVPLYPYAITTCQKWYSVVEGDYCQKVEQQFGISASELQSWNTGLDDTCTNLWKGYQYCVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5H6</accession>
    <name>A0A9W9X5H6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Triosephosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_005801</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789275.1">
        <property type="nucleotide sequence ID" value="XM_056935403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5H6"/>
    <dbReference type="GeneID" id="81625652"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000270">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF2">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5484005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="283" mass="29773" checksum="D62BB63E51DF99D5" modified="2023-11-08" version="1">MTSSTYPTLPEKLLLISLKMYFTPERTLSYLHSILDPAKEIVHSQNRDKLLLALIPDFLTIWPCAEVIKTYEAQLATSGVSNTSPAFLLGAQDCMWEAYGAYTGEVSPAALKSLGCSIVELGHAERRAIFGEKDDQTARKAAATCAHGMVPLVCVGEVTAPGAVASQAVGQAVSECALLVRAVLAAIPAEAPVIFAYEPVWAIGKPKPAGVDHVAAVVEGIREVIGPRAGALRVLYGGSAGPGLWGAGGLGKAVDGMFLGRFAHEIDGVRKVVHEVEESLGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X652</accession>
    <name>A0A9W9X652_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylisocitrate lyase</fullName>
            <ecNumber evidence="3">4.1.3.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_004814</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.30" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789610.1">
        <property type="nucleotide sequence ID" value="XM_056934416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X652"/>
    <dbReference type="GeneID" id="81624665"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF13">
        <property type="entry name" value="MITOCHONDRIAL 2-METHYLISOCITRATE LYASE ICL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="156"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="266"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="482"/>
            <end position="486"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5484826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="611" mass="67605" checksum="C5241742C66338DC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6Q1</accession>
    <name>A0A9W9X6Q1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_005481</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790277.1">
        <property type="nucleotide sequence ID" value="XM_056935083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6Q1"/>
    <dbReference type="GeneID" id="81625332"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="55"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="149"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5485493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="266" mass="29018" checksum="99E43A0E30DC83DD" modified="2023-11-08" version="1">MPVTVGVLALQGAFIEHVKLLKTAAEQEGFTDWDFIEVRTPQELEKCDGLVLPGGESTTMSLVAARSNLLEPLREFVKVHRKPTWGTCAGLILLAESANKTKKGGQELIGGLDVRVNRNHFGRQTESFQGPLELPFLGEGAAPFPAVFIRAPIVECILPPQSGIQEEEAQREDTITAPSRPARNSVAESANKDVEVMATLTGSAARHATQGRDVSPDQELGDVVAVRQGNVFGTSFHPELTGDSRIHAWWLHQVQDAVKRRQKRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X714</accession>
    <name>A0A9W9X714_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_005455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790251.1">
        <property type="nucleotide sequence ID" value="XM_056935057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X714"/>
    <dbReference type="GeneID" id="81625306"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5485467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="288" mass="32902" checksum="989946E92AA62CA7" modified="2023-11-08" version="1">MAEDSFSRLLSARLRQLGLEDDLKSRLMGRFSNNDAGDEFDASSDDESASPAIDNARLRFEIAAELTAELTDDLREAQETGARLQQMIEDPQIRCSVLPSLLTLSSLAMDDWVIHRNHNELQPHGFFCGNVSSALDIPRYGYSLVDFHQYDWPTNGISNLWRGRVAPGVMFIENIERRGRTGPWSSQLMQVAYETVAEISTLRTIFVANVVNRNTVPAAEWVLSFEQVQVCEFDTPEYQLLLGTRIGRVIAYFVLGAYGQGIRRISRIQIWWHTREEHLQMRFDLEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCA7</accession>
    <name>A0A9W9XCA7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst complex component EXO84</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exocyst complex component exo84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_003411</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the exocyst complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO84 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790554.1">
        <property type="nucleotide sequence ID" value="XM_056933013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCA7"/>
    <dbReference type="GeneID" id="81623262"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000264">
        <property type="entry name" value="Potential exocyst complex component Exo84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25345">
        <property type="entry name" value="PH_EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst component Exo84 C-terminal" evidence="14">
        <location>
            <begin position="452"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="664"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="139"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="671"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5488521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="683" mass="75629" checksum="0EB38A5994E514FE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCD8</accession>
    <name>A0A9W9XCD8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Proteasome inhibitor PI31 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_003368</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790511.1">
        <property type="nucleotide sequence ID" value="XM_056932970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCD8"/>
    <dbReference type="GeneID" id="81623219"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045128">
        <property type="entry name" value="PI31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013886">
        <property type="entry name" value="PI31_Prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
        <property type="entry name" value="PI31_Prot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266">
        <property type="entry name" value="PROTEASOME INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266:SF1">
        <property type="entry name" value="PROTEASOME INHIBITOR PI31 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08577">
        <property type="entry name" value="PI31_Prot_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11566">
        <property type="entry name" value="PI31_Prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator N-terminal" evidence="13">
        <location>
            <begin position="25"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="PI31 proteasome regulator C-terminal" evidence="12">
        <location>
            <begin position="248"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="161"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5488478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="35797" checksum="AA70A80D29677E19" modified="2023-11-08" version="1">MATNNPLGAEHVLEAAAKALGNDPSKLQTAYEAVALIGHASLTDSIDSSLTESNALPAEWNAGSTYAFRYAHPQSSMQYLLKVSRLGNNAVVFALALGDDRTSSFDLPVKDYISPSALPLSQSGSTSDALRDVFISRARLNDLVGLFKINVIQRLAPGLYKEGYEDRGPRGQEQEPPEASRQRDRLRDDSLPQPARPYPFDDPLAEAPRRPNPPGDFAPPGFEDEYEINRPPRGYPPGFPGGRSPFNIGERDLYPAGLGPNDPLRGSIGPGFGGGGMHPTFDDPLFGGRGGPGGGYDPRAPPGARYDPPGPGFGPPSGRGRGPGGGGFGGFGGGFGGDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCM8</accession>
    <name>A0A9W9XCM8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAM50A/XAP5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_003358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790501.1">
        <property type="nucleotide sequence ID" value="XM_056932960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCM8"/>
    <dbReference type="GeneID" id="81623209"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048337">
        <property type="entry name" value="FAM50A/XAP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007005">
        <property type="entry name" value="XAP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722:SF0">
        <property type="entry name" value="PROTEIN FAM50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722">
        <property type="entry name" value="XAP-5 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04921">
        <property type="entry name" value="XAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM50A/XAP5 C-terminal" evidence="2">
        <location>
            <begin position="192"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5488468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="372" mass="41239" checksum="FCD686373E99CF9C" modified="2023-11-08" version="1">MDSSEQESRVSTPRSFTGQSVSAEDMLKSQTVGLVHLSDFRKRRAEVLEQKEKEAHDKSLGRLASGNSRSATPSASDATDGPSAPRSDVPPKKKKKKALAKSKLSFGDENDEAGETSPPTTRDPSLSRSVSRTPAEEALPPASAANAPRMKANPNAPPPPKALTKAALEAEAKARDALRKEFLAMQEAVKNTEIAVPFVFFDGTSTRGGSVKMKKGDHIWLFLDRCRKVGAEMGVGGNSGASKARKEWARISVDDLMLVKGDVIVPHHYDFYYFIANRVPSYTRAGGLLFNYSDKPIPAQRKDEDPMYRPIEQELEGVDNDANDTKVVDRRWYERNKHIFPASLWNEFEPGKEFEEKMTSTRRDALGNTFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCW2</accession>
    <name>A0A9W9XCW2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791093.1">
        <property type="nucleotide sequence ID" value="XM_056933552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCW2"/>
    <dbReference type="GeneID" id="81623801"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF3">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="1">
        <location>
            <begin position="205"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="376" mass="43120" checksum="066E4C48C3BC2171" modified="2023-11-08" version="1">MKDSPNMAEDQQKYRHNQSNLNISNQFFGARYRWSTVPQDAPQSTEEAQALIDQLYLSGGPFFSKEMIRLAFEQCQRKPVRGEMLYINDVTGAVVEFECQTGEVKIQIDHDGEKSTYLLLDPVLSYECRAHLKHHLWWTGIREDRSPFCSLTLLHPSFKFKTDTREPIDPTPRRPPEAVAQEFLDRSRKWQKSEVAQQLVHILCAHAAGHEISKIIGLALGAISYDTDDRSRSFVQHALLLTLQDWLMGRDKKDKPVCYAQDPAYRSVDRQILKEHGIEAIDDPRAWLEIDNESIVFSVAPNVPVKEIVADIARPAIVIWERVGYNDADREGKMSCTDPDSPRVRAMLAQYEVFDFGAEDDPDFCKTVIYIRRCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDB3</accession>
    <name>A0A9W9XDB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED16</name>
        <name evidence="12" type="ORF">N7539_004165</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDB3"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048338">
        <property type="entry name" value="Mediator_Med16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048339">
        <property type="entry name" value="Mediator_Med16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021665">
        <property type="entry name" value="Mediator_Med16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13224:SF6">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13224">
        <property type="entry name" value="THYROID HORMONE RECEPTOR-ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20719">
        <property type="entry name" value="Med16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11635">
        <property type="entry name" value="Med16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med16 N-terminal" evidence="10">
        <location>
            <begin position="143"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit 16 C-terminal" evidence="11">
        <location>
            <begin position="809"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5489275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="951" mass="104944" checksum="FEF421EAEB30AADE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDS8</accession>
    <name>A0A9W9XDS8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="12">3.2.1.67</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Galacturan 1,4-alpha-galacturonidase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Poly(1,4-alpha-D-galacturonide)galacturonohydrolase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_004424</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="12"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791567.1">
        <property type="nucleotide sequence ID" value="XM_056934026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDS8"/>
    <dbReference type="GeneID" id="81624275"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000040">
        <property type="entry name" value="Probable exopolygalacturonase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF6">
        <property type="entry name" value="EXOPOLYGALACTURONASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040873469" description="galacturonan 1,4-alpha-galacturonidase" evidence="17">
        <location>
            <begin position="17"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5489534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="431" mass="47478" checksum="834A629953FE6F4B" modified="2023-11-08" version="1">MKFLAIGALLFGAVAAFATDHIPQGASLIAANDVSSLKGCGAHGQKYPNRRTVTIRASKNDKDDISDDFLWAMKRANHGGRVLLKKGKTYVIGKKLDLSFLNDIEVQLEGEIKFTDDIKYWQANNFYYDFQKSITFWVWGGQDIKIFGHGTLNGNGQAWYNAFAGREILDSKNTFYRPILFLTDNATRISVEGITQLNSPCWTNFFVRTNDVSFDDVFINAYSTNASALPKNTDGFDSLNVNGLRVTNTRVDIGDDCFSPKPNTSNIFVQNLWCNNTHGVSMGSIGQYAGVKDIIEHAYIENVTLLNGQNGARLKAWAGESAGYGRINNITYRNIHIENTDQPVVLDQCYFNINSTECAAHPSAVNFTNIVFDNIYGTSSGKKGREVVDLTCSPNAVCADIHLSRINLTVPPLISCNGIQGEVGVPCTKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDV9</accession>
    <name>A0A9W9XDV9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maltose/galactoside acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_004465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791608.1">
        <property type="nucleotide sequence ID" value="XM_056934067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDV9"/>
    <dbReference type="GeneID" id="81624316"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF76">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16628">
        <property type="entry name" value="Mac_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Maltose/galactoside acetyltransferase" evidence="4">
        <location>
            <begin position="624"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="262"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="401"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="510"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5489575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="825" mass="89764" checksum="545E343C33A84D9B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE09</accession>
    <name>A0A9W9XE09_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791040.1">
        <property type="nucleotide sequence ID" value="XM_056933499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XE09"/>
    <dbReference type="GeneID" id="81623748"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="849" mass="94389" checksum="AD39A6B4D3D3E733" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE22</accession>
    <name>A0A9W9XE22_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_003912</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791055.1">
        <property type="nucleotide sequence ID" value="XM_056933514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XE22"/>
    <dbReference type="GeneID" id="81623763"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000030">
        <property type="entry name" value="Thymine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="195"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5489022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="353" mass="39203" checksum="8470CA803E3AD730" modified="2023-11-08" version="1">MAGHLQELNPVSNAVSKDDLVIPLIDFGPFSTGTPSDKHAVALSITNAFKSSGFIYLKDHGIPPSVVSRVFASSATFFRRPQSQKDALGWTTPQSNRGYVAIGREKLATVEETGQMETLRGAAPDIKETMEIGREGVDGLPNQWPDHLDEEGKEFKKTMLSFFDMCKELHKQVMCAIALGMSLPEHFFDEFVDEGDNNLRLLHYPPVRKDVFKQNPHQVRAGEHSDYGSITLLFQDRHGGLQVRSPKGTFVDATPIPDTIVVNAGDLLARWSNDTIKSTRHRVIEPPKPAALDEQDSSETYPSRYSIAYFCNPNNNKLIEALPGTYGEDINESKKYAGITAGDYLVQRLTATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE34</accession>
    <name>A0A9W9XE34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Geranylgeranyl pyrophosphate synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791206.1">
        <property type="nucleotide sequence ID" value="XM_056933665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XE34"/>
    <dbReference type="GeneID" id="81623914"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF2">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="439" mass="49159" checksum="459EB5105CB5D856" modified="2023-11-08" version="1">MSDTSEQLVEISRIDLDCTGPAKAIITDVKHLASYNWIEASTPTIAVPGSPARWSAPQGTRQVKKDSGLVYIAQNAARHPDSPLEPLFRSLYIEHPLFDINSIDVITDRNNIRKLLSFIKPTLTKNGLDPFTIQVDMAAQTAIFCRDETATFEVIGPGEFRGFGHEFERAYTINQVRDSTGHHRIISYRLGGLSFLVRHETDGFVEDWKPVVEKDKSTGDNLANILQSLSLSPENDTTDETSVQSKLTIKREGRVVPRESTLEIKTRVVHKPLELSEVAPQLWISQTPKLARAYHQRGIFSTPKVEDITAGLKDWEQTHQDLIRKLVALINCILRVTRSWGGSSTIRYDFLKDKLVIKKVERKKMLPDDLYSRWAKAIPVDVEQKISENRSAPTQKGSDTLQRTTKLDRGNSPPSGTKAGPAKLQHHVNVAAAGKKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEA1</accession>
    <name>A0A9W9XEA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial ATPase complex subunit ATP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791311.1">
        <property type="nucleotide sequence ID" value="XM_056933770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEA1"/>
    <dbReference type="GeneID" id="81624019"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="40573" checksum="EEF20EA5ECC5D03E" modified="2023-11-08" version="1">MWNSRFHTVLNAGWKFASVCQPPINQLRSTAVPTGTKTQRLRQYATTSHTQDTNRKDNGDAVMVSSPVQRQAQALRRGVQFQQNQDMKPQPGDKDFKPPMLDRPIGTNTPPMAGENTGVDLRSLKQRRDDFVNYDRHLERRKELTRQVAKPYFREWSNLRFLEGKTFVSNPRLFKGDKALYFPNMSGITLAEQKDRQDTTPVLQGKISVVKLFSSVWAETQVGSFTGPTQNPHLTELLANNPQFAQMVDINLEENRMKATLVKMFMWSMRRKLPEQQHPRYFLVQKGFTESLKEAVGMMNSKVGYVYLVDSECRIRWAGSGNAEPAEMETLNVGLQKLITERKAIFEAEGVNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEX5</accession>
    <name>A0A9W9XEX5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_002474</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792036.1">
        <property type="nucleotide sequence ID" value="XM_056932077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEX5"/>
    <dbReference type="GeneID" id="81622326"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5490907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="594" mass="66254" checksum="88C68BE839741969" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEY0</accession>
    <name>A0A9W9XEY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_002443</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792005.1">
        <property type="nucleotide sequence ID" value="XM_056932046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEY0"/>
    <dbReference type="GeneID" id="81622295"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04938">
        <property type="entry name" value="TGS_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01899">
        <property type="entry name" value="Ygr210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.470:FF:000001">
        <property type="entry name" value="GTP-binding protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000030">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="YGR210-like_G4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF1">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="YGR210-like_G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="5"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5490876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="444" mass="48469" checksum="E946B3E87130DDA8" modified="2023-11-08" version="1">MPRDPLIGLVGKPSSGKSTTLNSLTDASSKVGKRCRDHETKEEEASTGARANHKSAGPPPVGNFPFTTIDPQRAVGYLQIECACLRHNVSDRCQPNYGGCHEGRRSVPIELLDVAGLVPGAHQGRGLGNKFLDDLRHADALIHVVDVSGTTDAEGKATRGYDPSVDIEWLHSEIVRWVLGNLMEKWGSIKRRHVATKANPVDTLQGQFSGYGSTSTIVARCLDRLALKEPLESWSNETVEIVVKAFIDEKFPMVYALNKIDHPDADKNISKIAKMQDPQAIVLCSAISEVFLRRLAKQGYIKYVEGSEFVDTREDLIEMGDPDGGGLKEMDEKLKARVENLKDMVLYRFGSTGVVQCLSRAAERLGLVPVFPVRNVQTFNSGSGSAVFRDCVLVKKNSTVGDVARKVMGDVPISYIEGVGGTRVSEEDIVAVGKHDILSFKVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF17</accession>
    <name>A0A9W9XF17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_002598</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792160.1">
        <property type="nucleotide sequence ID" value="XM_056932201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF17"/>
    <dbReference type="GeneID" id="81622450"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5491031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="346" mass="36977" checksum="1DA696B9519EA245" modified="2023-11-08" version="1">MVAFLSCFLVRFVAGPLCDRFGPRLVFVGLLLAGSLPTVMAGLVTTPQGLIALRFFVGILGGTFVPCQVWCTGFFDKKIVGTANALAGGWGNSGGGITYFLMPAVFDSLVSAQGLTPHKAWRVTYVIPFVIIVSVALGMLFFCEDTPTGPWADRHLWAEKTANTQTTPGGKVIDLRSGVSSSGPSTTPSLYNMGLDDVEKKGAQSPHIFDRDDPAPAMGQFTTISPDTVVAPTRKEALSVAFSLSTFAVAVPYACSFGSELAINSILGTYYEKNFPHMGQTKTGQWAAMFGLLNVVCRPVGGLLGDFLYRSTGSLWSKKLLLTSLGLLMGAFELAIGFTDSWWQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFH2</accession>
    <name>A0A9W9XFH2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_004647</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791790.1">
        <property type="nucleotide sequence ID" value="XM_056934249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFH2"/>
    <dbReference type="GeneID" id="81624498"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="42"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="208"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5489757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="327" mass="35962" checksum="15D55BEBED070941" modified="2023-11-08" version="1">MTSSSTPFTSLFVTPSEFHRVLSRTSDCDPNGPRVIPLVAGRKSNVQSFEAQHVPGSIFFNMDTMRDTSSPYPMMLPTTSQFASYMSKLRIKPDDVLVVYDPLEPGFYSSPRVAWICRYFGHRAVHILNTFPRYVEEGYPVAEGPVNGGFSGTEALDGDGDGCDKSKNERDSVGSYPESLLPDPERVVAFEELRGMIKDGLTQEKDKELKELQIIDSRPSNRFSGPVDPDLSVLPRGHIPSAINVPFSSLVGPENTVRSPDELKQLFITAGVKQNVPTVLYCNTGVTAAGLDMALKASGLAVQTRLYDGSWSEWSKRADQPGEKVCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFH3</accession>
    <name>A0A9W9XFH3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose-induced degradation protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792290.1">
        <property type="nucleotide sequence ID" value="XM_056932331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFH3"/>
    <dbReference type="GeneID" id="81622580"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5491161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="316" mass="35705" checksum="F578C2C5FC305957" modified="2023-11-08" version="1">MPTPSATRPNSITEVISTRTCPPELDRLSDGRGTPDSLVSQGETVDDALTSIGALAPSALRRSDDGSALSTSDPLRVESKTSGAPDDDTASRERSISPWDRNAGDQSSVTPSNSSLLRYEFSNVRLLPNYSSSFLRSGSKFVGKQMSDKQEYNVDVEIIHVDMAESYLCGYLRIQGLTEDHPTLTTFFEGEIIGTKHTFQTRNEQWGANEKIDIHHWSRFPAWKPLAKQAKRTDFTYRNFAQREHVFMRWKEYFLVPDHRVRTISGASFEGFYYICFNQIEGSVSGVYFHAKSERFQQLELKHVEDHGCAPAVEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFU7</accession>
    <name>A0A9W9XFU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792595.1">
        <property type="nucleotide sequence ID" value="XM_056932636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFU7"/>
    <dbReference type="GeneID" id="81622885"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="118" mass="13073" checksum="0B8B6BB1937D44F3" modified="2023-11-08" version="1">MAKISIISNELMDPIASYLGKNDESTLVIRCVARARGLIRLPCLGFHHRGAPANPSTGRIHDPESGSGTIDSFFEKLDTEHRDNNERNQPPGTPSEESYRAVMMPHDQGYQAWNRAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFX1</accession>
    <name>A0A9W9XFX1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792530.1">
        <property type="nucleotide sequence ID" value="XM_056932571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFX1"/>
    <dbReference type="GeneID" id="81622820"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="467" mass="51197" checksum="86B70699EE72DCB8" modified="2023-11-08" version="1">MNQLPLRSHRAAQLQRTVTCQLCEFSSTQARRSFSVGRGAAAAAAASNPRILTIRRPIVSRSSRLSLAQPLACQTGTLRYRSRQASSKNAHLLESEKQAVEGLETEHVANANGHSNASPANSHLSLREITSMIEGCAQKTSELLARSEVPGNAEVEELLLKYEEAARAIAPYWDVRDENAPSGEGKGNAVSSLLEMQEHEGSVTHIRDAEEILRTLADQVSTSMTQIIKDEKVFISPKALEHYIRAQCTLNRAEYLPEVFHLYANKPIPEEKSNPPKLHQANPKDVNSAVSADLANQAIDVAIKQKNLPLVLAMIDNTFCAPAFHHAKVFRRAAVPLVGLAAAPAACFTLASWASTLQNTMDPSTATGIAFAASLAYVAGTSSIGILAITTANDQMKRVTWLPGIPLRHRWLREEERAALDKVACAWGFRDPYMHGEETGEEWESLREFIGMRGMILDKTELMEGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG28</accession>
    <name>A0A9W9XG28_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792252.1">
        <property type="nucleotide sequence ID" value="XM_056932293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG28"/>
    <dbReference type="GeneID" id="81622542"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027921">
        <property type="entry name" value="NOPCHAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38489">
        <property type="entry name" value="HISTONE CHAPERONE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38489:SF1">
        <property type="entry name" value="HISTONE CHAPERONE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15370">
        <property type="entry name" value="NOPCHAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5491123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="200" mass="21205" checksum="3241BE9C1F49EBB8" modified="2023-11-08" version="1">MSAVSAKSTPQRREDKDPLASDDDPTSSSGSSSSESESESESDEGDSSDEREDADMHDATGPTSTSAPSIPSLAGRPKPNIHRVNGGSDLLSRLSAFLPKLKDANEDLEKEIAAGRGQEMVLDSVDEDGKDYIEMNLGLGVLEEKRDGDPDVLGGEVDDDENAKSDEDKLDADGDSDLLGQLMGGITSSKIKPSIEEMME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGP9</accession>
    <name>A0A9W9XGP9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyl hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793097.1">
        <property type="nucleotide sequence ID" value="XM_056931066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGP9"/>
    <dbReference type="GeneID" id="81621315"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF2">
        <property type="entry name" value="ENDO MANNANASE, GH76 FAMILY (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040891380" description="Glycosyl hydrolase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="65020" checksum="8BB4C7E8ED8B8FCD" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGQ1</accession>
    <name>A0A9W9XGQ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793088.1">
        <property type="nucleotide sequence ID" value="XM_056931057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGQ1"/>
    <dbReference type="GeneID" id="81621306"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="34049" checksum="85757C0067FAF255" modified="2023-11-08" version="1">MRLKKSQRAEFFDEDEEVARPKPSRATRSLKPFRLLDLPSEIRERIYHFALFTPSRKSARKRNGTVGASAKKHKAFSPTAQRINLFLSCRRIHDEASYYFFSTQVFRLFSIQDFAQMPTVRQLPRSHRGSVTTIELILGNSWTAPPKNYTVNQGLGLHDMVLTRTLKVWIECDPSQPIFEGFRISKDFYTDFAGNLLRQILERLPNLVQVEFDAYPSVHKNGGLMTRLLEETRKFGKKVLWGPERGWVDDEDDFDPPEEDLVDCIGDNLQSAQPAMDILSETLQLIRLEREAVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGT0</accession>
    <name>A0A9W9XGT0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 20">ATP-dependent DNA helicase II subunit 2</fullName>
            <ecNumber evidence="5 20">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">N7539_001345</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of Ku70 and Ku80.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the ku80 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="5 20"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792979.1">
        <property type="nucleotide sequence ID" value="XM_056930948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGT0"/>
    <dbReference type="GeneID" id="81621197"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.240:FF:000002">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000008">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000073">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016570">
        <property type="entry name" value="Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 20" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15 20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16 20" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 20 23" id="KW-0347">Helicase</keyword>
    <keyword evidence="10 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="VWFA" evidence="22">
        <location>
            <begin position="6"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR016570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAJ5492599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="717" mass="80163" checksum="3D16E57ADAB4C8CB" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHB2</accession>
    <name>A0A9W9XHB2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome c oxidase assembly factor 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_001739</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793373.1">
        <property type="nucleotide sequence ID" value="XM_056931342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHB2"/>
    <dbReference type="GeneID" id="81621591"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000003">
        <property type="entry name" value="Cytochrome c oxidase assembly factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048281">
        <property type="entry name" value="COA6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5492993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="115" mass="13355" checksum="0D0B9B281C7F7D2B" modified="2023-11-08" version="1">MGWLPWSSGDSNKASDGGRIAPDRTSRARCWEGRDMFFACLDRNEIIDSIKDDKAARRKCAKEVAEFEAACSATWVKYFKEKRVMEYNRDKTIERIKKEDAEKVKELKTQGWKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHG4</accession>
    <name>A0A9W9XHG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793070.1">
        <property type="nucleotide sequence ID" value="XM_056931039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHG4"/>
    <dbReference type="GeneID" id="81621288"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="186" mass="21099" checksum="2BD2BFF1A821F94B" modified="2023-11-08" version="1" fragment="single">YRRRTKNLFSRRIRELEEAIRRRDLPVIYEIAELTRRLGFKSTDIDSPRDKNISLPELNIEIAPIDLAIASLYSSYYSTSPRDIDTTSNYTRISFEVNIPKQNSLVPASSNEPAAPIYADIEHLSSALNVTSHDLSPVSRRKGQLEPIVKHPDQRRPSSRDIIRNLSTHASSTNKSRAREAGSSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHH8</accession>
    <name>A0A9W9XHH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793015.1">
        <property type="nucleotide sequence ID" value="XM_056930984.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81621233"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="699"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="772"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1252"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5492635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1377" mass="152105" checksum="0F6E9B720101459F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHN7</accession>
    <name>A0A9W9XHN7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_001290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792924.1">
        <property type="nucleotide sequence ID" value="XM_056930893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHN7"/>
    <dbReference type="GeneID" id="81621142"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510:SF1">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="50"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5492544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="410" mass="45559" checksum="1A0B13DD94C413E3" modified="2023-11-08" version="1">MVKIEAFAVEQWMDKYETTAKFNTAETCCASVSIDDLRALCENKDKDPLVGLQSMKLTYGAIRGSDQLRETLSNLYSAKTPGLTSKESILITNGAISANFLLLYTLIGPGDHVICHYPTYQQLYSVPASLGAEVSLWKANESKDWQLDLDELKSLIRPNTKLVIINNPQNPTGAIVPRDTLQGLVEIARESSITLFADEVYRPVFHNISPMDPQFPPSLLSLGYEHSVVTGSVSKAYSLAGLRVGWIASRNESIIEACASSRDYTTISVGQLDDAIASFALGPDCIHNLLRRNIELARTNLAILEKFIESYRWACDWIKPRAGTTAFVRFNKMGKPVNDVAFCEMLHDRKGVMFVPGSLCFGGGEEFRGYVRIGYACETHVLEQGLDRLRDFMEDDYDDVPALKKAKSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHV7</accession>
    <name>A0A9W9XHV7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793642.1">
        <property type="nucleotide sequence ID" value="XM_056931611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHV7"/>
    <dbReference type="GeneID" id="81621860"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1079" mass="122661" checksum="26C3DD03FB1048A4" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHX5</accession>
    <name>A0A9W9XHX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_001425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793059.1">
        <property type="nucleotide sequence ID" value="XM_056931028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHX5"/>
    <dbReference type="GeneID" id="81621277"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5492679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="86" mass="9441" checksum="8A4353CC573583DC" modified="2023-11-08" version="1">MGEVSTPLMAADNIKFGPESIYYVVDDSVKARTNTYRAKIMALAQFARNVFDSTVLEGVRLDKEEARSIIFKLGEAKAKKDAPGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHY5</accession>
    <name>A0A9W9XHY5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Repressor of RNA polymerase III transcription MAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793697.1">
        <property type="nucleotide sequence ID" value="XM_056931666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHY5"/>
    <dbReference type="GeneID" id="81621915"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1000.50:FF:000004">
        <property type="entry name" value="Repressor of RNA polymerase III transcription MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037240">
        <property type="entry name" value="RNA_polIII_Trep_MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5493317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="320" mass="36538" checksum="E2E4D6FD7732C23B" modified="2023-11-08" version="1">MKFLPLPEFEDITSSLNFDTADCHITGGCDLYTTKAARSDRKLYNHIEQSLEAQYESILRLSASLSPPNAHDAAETLNLSRSSPFGPLSEHSSRRTFAYLIATLNASHSDYDFSHVLRPTDFRRERHLKRVMNTVNSTLFNLRPRESIDMSPSSPGTLPGSYNSGSTTWGSRMWQSIDEHMSLKECALYSYSPEEDPSDADDGAIWSLHYFFFNPLRKRVCYLYLRAIPILSHTPPEDNELISTSIGKRTFDDGYLTPDLSSSKRARYWFGAHTESSLHRAENLEDDDQYIHSDEENHSRRGSRGMVRAMSEELVEMMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI42</accession>
    <name>A0A9W9XI42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-amylase A type-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002034</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793668.1">
        <property type="nucleotide sequence ID" value="XM_056931637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XI42"/>
    <dbReference type="GeneID" id="81621886"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11318">
        <property type="entry name" value="AmyAc_bac_fung_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013776">
        <property type="entry name" value="A-amylase_thermo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006968">
        <property type="entry name" value="PRK09441.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006969">
        <property type="entry name" value="PRK09441.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001021">
        <property type="entry name" value="Alph-amls_thrmst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="7">
        <location>
            <begin position="29"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5493288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="530" mass="60007" checksum="6ACB61F0691E10F5" modified="2023-11-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XJF8</accession>
    <name>A0A9W9XJF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gamma-glutamyltranspeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793854.1">
        <property type="nucleotide sequence ID" value="XM_056931823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XJF8"/>
    <dbReference type="GeneID" id="81622072"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052896">
        <property type="entry name" value="GGT-like_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881:SF1">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="64381" checksum="45E3F31707D687EC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XKV8</accession>
    <name>A0A9W9XKV8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793899.1">
        <property type="nucleotide sequence ID" value="XM_056929606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XKV8"/>
    <dbReference type="GeneID" id="81619855"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5494886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="87" mass="8765" checksum="A3ACE9C2533E3308" modified="2023-11-08" version="1">MVRGADYDNGVPQSDNPIEAGSTQAHGTGATDAPLDRTQKVAPMPEETGSQRDVFPGQAGAGHSSGKGGHEPKTLGENKGLGAQPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLN3</accession>
    <name>A0A9W9XLN3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytosolic Fe-S cluster assembly factor cfd1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_000368</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794265.1">
        <property type="nucleotide sequence ID" value="XM_056929972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLN3"/>
    <dbReference type="GeneID" id="81620221"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5495252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="294" mass="31605" checksum="B6C7AD24E70A26A0" modified="2023-11-08" version="1">MPLDGVKNIVLVLSGKGGVGKSSVTLQLALALSLHGKSVGILDIDLTGPSIPRLVGLEDAKITQSPTGWLPVPVHEAVVAQNDDEPSSEKKTRARGSLRCMSLGFLLRDRGDAVIWRGPKKTAMIRQFLSDVAWGPTDYLLVDTPPGTSDEHIALAEQLLTLSTTDAAVATQMNLPRLQGAVLVTTPQAVATSDVRKEANFCVGGGEVMAQELNIPFMGRVPVDVKFGELVEGNLEVETDDEDDDEDNLKDGGEKTAQKASPAEPDTRPLVEKYQEGWSYTRFEEFARTIIASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLU5</accession>
    <name>A0A9W9XLU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonucleases P/MRP subunit Pop8-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794420.1">
        <property type="nucleotide sequence ID" value="XM_056930127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLU5"/>
    <dbReference type="GeneID" id="81620376"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020347">
        <property type="entry name" value="Pop8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049128">
        <property type="entry name" value="Pop8-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20976">
        <property type="entry name" value="Pop8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonucleases P/MRP subunit Pop8-like" evidence="2">
        <location>
            <begin position="41"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="163" mass="17070" checksum="239F90E1A2A7F7DA" modified="2023-11-08" version="1">MADASKQAGSTQTPVTNPGAPKRKAPEANPNTIHFTSRNPPWTYLKLQLIPQPDAPALQPLDELSARTYLSSALSQFLGLTGTAIPIDILKVENRDRAASNGSNKYDSVWIRVPRDDGAAVVAAISSWIGGSGSGSGAAWRICAKGNFLGALVAGSGQDLFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM62</accession>
    <name>A0A9W9XM62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_000564</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794461.1">
        <property type="nucleotide sequence ID" value="XM_056930168.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81620417"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="11"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5495448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="241" mass="26400" checksum="F343FEF77D00ACA8" modified="2023-11-08" version="1">MAQPLDLSRPTALVLIDNQFAFTNPATVSHWGSSRSNPHYEANLQSLLHHFRTARATSPSASKNLHIIHVFHASDSPTSPLHQEHPSGGIQPLDFAIPAADGSEPVFWKDVNSAFIGTELESHLRKLNIRQIVFAGLTTDHCVSTTVRMAANLRIVDILWGTDLTYRQKGDHIHDFELVDAKGEQDDGRIILAADATATFAKGGFDAETVHQVSVASLEGEFADVLRTEMIVEALENYGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN77</accession>
    <name>A0A9W9XN77_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794603.1">
        <property type="nucleotide sequence ID" value="XM_056930310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN77"/>
    <dbReference type="GeneID" id="81620559"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="311" mass="31878" checksum="F0B7B782035976A2" modified="2023-11-08" version="1">MSSHAPPPGPPPPSVPEGWKAQYDERYQTWFYINTATGKSQWERPEVPSAPSAAPSGPPPNADYQYRPQSAGLPGDDKKTMASNNPYNTINQSTTNNIDDDARLAAKLQAEEDSRARSATGDRGAASDYYGGDASQAPPGYGASAGASGPGPSQSPMPEQKRSKGGFLSKLMGKASGSSSSSRPQYGQQYPSQQPQQYAAYPPQGQPQGGYYGGGFPPQQPGYAGYPPQMGYGGGYGPPPGGMYAQQPARRTGGGGMGTAGAAALGVGGGLLGGMLIADAMEDHNDYGGGGYGDDYGGDYGGGDDFGGGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN91</accession>
    <name>A0A9W9XN91_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centrosomin N-terminal motif 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795109.1">
        <property type="nucleotide sequence ID" value="XM_056930816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN91"/>
    <dbReference type="GeneID" id="81621065"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
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        <location>
            <begin position="481"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="642"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="773"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="906"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="208"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="546"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5496096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="969" mass="107675" checksum="C201D8FF2370B51A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XNE6</accession>
    <name>A0A9W9XNE6_9EURO</name>
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        <submittedName>
            <fullName evidence="7">DNA-directed RNA polymerase IIIand III subunit RPABC4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_001254</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056930858.1"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:DNA binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0003899">
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:DNA-templated transcription"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
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            <begin position="1"/>
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    </feature>
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            <begin position="12"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="KAJ5496138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="77" mass="8694" checksum="3CC07AC36BAE2A29" modified="2023-11-08" version="1">MSREAYQVPSMGGSQNNFSNEGSGSAMAVDSPAINYICGHCSSRVPLRRSEHIRCKECGHRVLYKERTKRMVQFEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJE0</accession>
    <name>A0A9X0BJE0_9EURO</name>
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        <recommendedName>
            <fullName evidence="3">Brl1/Brr6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">N7539_008916</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Brl1/Brr6"/>
    </dbReference>
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        <property type="entry name" value="Brl1/Brr6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136:SF1">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10104">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
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            <end position="377"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01042"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5469298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="473" mass="53715" checksum="31BB02DA9B7EF7F4" modified="2023-11-08" version="1">MNSRNEAGGVIPMDYEWHGGSSGPVDFTSPFSHVRRQPSQDNKKRSHQVFESPEKPSIPALRPPNSQSSFLFSPPRQQAATQSQSSIFGQPAFMTPRKLEVDFSSGAENFSSPEIADNEETPEQQTRGTRRNSLFNQYGRFAPSPGRGEIPRKNIYSRAAARKVQKRRTRNRDRAIEREVQLDDDDEDDDSDRPGSNEGRIEKKRRQKIAEPGTAPSQSSSARMGFFKQVLTLLEEHPNVPAILSWWAQLVVNLSLFSLAVWMVFSFVAEIRNEFDAVASKEMDSILHSIAECMQRYEDNKCAAGNLVPGLIPICAADRKCMDTDPTHVRRAMLSARTMAQIIDSFIEPISWKAIIIFLATIGTVAWASNWSFRSFRNNRLNQGYPQHDYPPPPPPVYNPNMHGQALHLQQNPTYGFHGQQESPSKNYTERDEDAPLLLENTRAMDFVTERSRERESHLRTPSPSKRMHRQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJL0</accession>
    <name>A0A9X0BJL0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase-like protein ustS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_009202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786174.1">
        <property type="nucleotide sequence ID" value="XM_056938797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJL0"/>
    <dbReference type="GeneID" id="81629047"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione S-transferase UstS-like C-terminal" evidence="2">
        <location>
            <begin position="130"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5469584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="270" mass="29935" checksum="8F8D2ED756DE635B" modified="2023-11-08" version="1">MANIEPVHFFDITSTLPGAQKSWSPNTIKVRSVLNFKGIPYTQSWISYPDIAPLIKSLGIEPHKTGPAAYTLPAIVHKSSVTSNPHGAMMDSIPIILHLDKTFPSKPLFPSGDASYALLMAVMKITTATAPAPRTLIIPQVADQLDPRGKEYFIETRSKFFGKPLAEVRPTDQATIDQLWKDVESHIDTLAAMLRGREGKKGPFFEGETAGMADLYLASFMAWFERIDQTAFERFTSVGNGELKTLWEACKPWINGQGEEKEWPIPQAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BN62</accession>
    <name>A0A9X0BN62_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787119.1">
        <property type="nucleotide sequence ID" value="XM_056938027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BN62"/>
    <dbReference type="GeneID" id="81628277"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="76" mass="8468" checksum="51693857057F0209" modified="2023-11-08" version="1">MFWNLPWVYWDGLPEAFSQPICGRMERASAPHAAPHPDFLDPSRPPPQGALTEMKIHSKPLKAKASEGLALGLYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNA8</accession>
    <name>A0A9X0BNA8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_007797</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787263.1">
        <property type="nucleotide sequence ID" value="XM_056937398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNA8"/>
    <dbReference type="GeneID" id="81627647"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5475510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="230" mass="25736" checksum="DE791B8FF6B05D90" modified="2023-11-08" version="1">MAAVSKGHQVHPEGRTWKEHFSKGDLWVFGYGTDHRGTPEQPGRVVTVIDREFWETLGDPLAELESSSSSTGKVWGAAYHIPASHAEEVHDYLDEREIDGYSVRFTPFYPTRESSSESQEPITCMVYIGQPSNPQFLREPERRAPEDVAQVISAGHGQSGKNTEYLYLLEKALQGLGLGTADVHVTDLVERVRAIETAGLADEEEWQAERDVQASLSRSPEEVLQRDNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNH7</accession>
    <name>A0A9X0BNH7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Chitin synthase</fullName>
            <ecNumber evidence="2 11">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_007978</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family. Class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 11"/>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787444.1">
        <property type="nucleotide sequence ID" value="XM_056937579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNH7"/>
    <dbReference type="GeneID" id="81627828"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF11">
        <property type="entry name" value="CHITIN SYNTHASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="575"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="620"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="653"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="695"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="837"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="877"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="13">
        <location>
            <begin position="138"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5475691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="908" mass="101468" checksum="7061B3895DF3487D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNR2</accession>
    <name>A0A9X0BNR2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787401.1">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="164" mass="16878" checksum="BA8B501B1D941563" modified="2023-11-08" version="1">MSTTWNSSHSFSQASSLASTSVASATAATRSPSSHIVGVVEQPHQPPLNYSPLPAAPTNPAGAASLPHSSVSAYLAQPVMAQTQPLAQSLSNLTGAPAVEQQQIEGTEVTLSTHQPAAHYPHQVSGSGGPTATAPFLQDFSLVAEAAKRAQLSIIMRDLESVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BPA4</accession>
    <name>A0A9X0BPA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_007405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
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    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787805.1">
        <property type="nucleotide sequence ID" value="XM_056937006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BPA4"/>
    <dbReference type="GeneID" id="81627255"/>
    <dbReference type="Proteomes" id="UP001148312">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5477261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSH5</accession>
    <name>A0A9X0BSH5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-protein ligase E3A N-terminal zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_006862</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788398.1">
        <property type="nucleotide sequence ID" value="XM_056936463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSH5"/>
    <dbReference type="GeneID" id="81626712"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
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    </dbReference>
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        <property type="entry name" value="AZUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042556">
        <property type="entry name" value="AZUL_sf"/>
    </dbReference>
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        <property type="entry name" value="DUF7590"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
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        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF15">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23580">
        <property type="entry name" value="Znf_XAF1_N"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="185"/>
            <end position="260"/>
        </location>
    </feature>
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        <location>
            <begin position="287"/>
            <end position="413"/>
        </location>
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        <location>
            <begin position="658"/>
            <end position="687"/>
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        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5480968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="805" mass="89253" checksum="B6B5AAC8A7D225ED" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSJ8</accession>
    <name>A0A9X0BSJ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein FYV10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein fyv10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_006937</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788473.1">
        <property type="nucleotide sequence ID" value="XM_056936538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSJ8"/>
    <dbReference type="GeneID" id="81626787"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="209"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="6">
        <location>
            <begin position="487"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5481043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="706" mass="76475" checksum="D13C34183E8B73C2" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSV9</accession>
    <name>A0A9X0BSV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788471.1">
        <property type="nucleotide sequence ID" value="XM_056936536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSV9"/>
    <dbReference type="GeneID" id="81626785"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5481041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="342" mass="38030" checksum="981AB54688EDAB78" modified="2023-11-08" version="1">MADNLLKLEAQYFQLVEPRDLHIPPEDVLLQPAIQQALYERMFDESLPALPPAAYRTRVLKLITTLIEDAITDPDEDELNDNLMEAFGTLLAQPKPNSIELAQQLSSVKYTAPRESSESRPREVVTIESRGLILSGGTTGNRTWEAALHLGSFLATPEGDKLVRGKRVIELGAGTGFLSLFCARHLGVRSVVASDREPSLIANMQDCAVLNSDNECSLPFFPALWNWGTPLEISDDMPSLVENDMLSFDVALGADLIYDTDIIPLLLSTIEDLFENYHVKKFVISATLRNENTFQTFLDGCEQTNFRVEKIPYESIDSQSQSGFFHSTSIPIVTYQISKGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BTS3</accession>
    <name>A0A9X0BTS3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytosine deaminase</fullName>
            <ecNumber evidence="14">3.5.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cytosine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_005703</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolytic deamination of cytosine to uracil or 5-methylcytosine to thymine. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>cytosine + H2O + H(+) = uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16040"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from cytosine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.1" evidence="14"/>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789177.1">
        <property type="nucleotide sequence ID" value="XM_056935305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BTS3"/>
    <dbReference type="GeneID" id="81625554"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004131">
        <property type="term" value="F:cytosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046087">
        <property type="term" value="P:cytidine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019858">
        <property type="term" value="P:cytosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000016">
        <property type="entry name" value="Cytosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF190">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="17">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00084039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5483907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="142" mass="15287" checksum="95B912CE7DC5FCBC" modified="2023-11-08" version="1">MEQDPGFIAAVEEAKQGAAEGGVPIGACLVSKDGKILGRGHNMRVQKGSPVLHAEMSALENSGRLPASAYEGATMYTTLSPCDMCTGACILYKIKRVIVGENKNFVGGEELLISKGKELVILDNQECKDMMAKFIKEKPEPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BTZ5</accession>
    <name>A0A9X0BTZ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">mRNA 3'-end-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_005782</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CPSF4/YTH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789256.1">
        <property type="nucleotide sequence ID" value="XM_056935384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BTZ5"/>
    <dbReference type="GeneID" id="81625633"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000012">
        <property type="entry name" value="cleavage and polyadenylation specificity factor subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="198"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="203"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU369008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5483986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="254" mass="28892" checksum="6769D5ACD8397B1B" modified="2023-11-08" version="1">MTADVHSAASRVLSAEPMRDPSYNDFSFTPFLRRSFGFGLASDVPVCKAYGEGHCPLGPACPDRHPTPSRITTSTTTASGMAPSTTHGSLVCKHFLKGLCKKGVKCEYLHEYNLRRMPECASFSRSGYCPNGDDCLYQHVREEARLPPCEHYDRGFCELGPLCAKRHVRRKLCLFYLAGFCPEGKACANAHPRWTENLPRPTMRTEKTEEELEHERALIREEQEREKEREREWRSERGRGGGFMRGRYRGRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BU30</accession>
    <name>A0A9X0BU30_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789507.1">
        <property type="nucleotide sequence ID" value="XM_056934313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BU30"/>
    <dbReference type="GeneID" id="81624562"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345:SF2">
        <property type="entry name" value="HELICASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345">
        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="925"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5484723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1031" mass="115234" checksum="2C3A1C4C7D1D1762" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BU87</accession>
    <name>A0A9X0BU87_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab proteins geranylgeranyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789526.1">
        <property type="nucleotide sequence ID" value="XM_056934332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BU87"/>
    <dbReference type="GeneID" id="81624581"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017230">
        <property type="entry name" value="Mrs6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037514">
        <property type="entry name" value="Rab_ger_ger_transf_A_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5484742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="517" mass="55896" checksum="FEACD955587C5126" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUB6</accession>
    <name>A0A9X0BUB6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_004982</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789778.1">
        <property type="nucleotide sequence ID" value="XM_056934584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUB6"/>
    <dbReference type="GeneID" id="81624833"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057026">
        <property type="entry name" value="Znf-C2H2_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24537">
        <property type="entry name" value="zf-C2H2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="505"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5484994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="668" mass="73340" checksum="3216C86BE52A1547" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BV35</accession>
    <name>A0A9X0BV35_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_005570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inhibits the enzyme activity of ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790366.1">
        <property type="nucleotide sequence ID" value="XM_056935172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BV35"/>
    <dbReference type="GeneID" id="81625421"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5485582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="107" mass="12306" checksum="E6E8A7E22923BEB5" modified="2023-11-08" version="1">MHALARPLLRKPYHHSTRPLFFLARSLSSTTCTMGAGDTGAPRARGSLAEKDRFQQREAAQEAMYIRQHEMEKLERLRAKMKESQKHIAELDKHLEEYAKTQGGEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BV41</accession>
    <name>A0A9X0BV41_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heat shock protein 60</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_005585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790381.1">
        <property type="nucleotide sequence ID" value="XM_056935187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BV41"/>
    <dbReference type="GeneID" id="81625436"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5485597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="588" mass="61892" checksum="A726E8693BEA240D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BV56</accession>
    <name>A0A9X0BV56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arginine permease CAN1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_005539</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790335.1">
        <property type="nucleotide sequence ID" value="XM_056935141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BV56"/>
    <dbReference type="GeneID" id="81625390"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="58"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5485551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="553" mass="60253" checksum="1209AF0DC2B0E348" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXP6</accession>
    <name>A0A9X0BXP6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790581.1">
        <property type="nucleotide sequence ID" value="XM_056933040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXP6"/>
    <dbReference type="GeneID" id="81623289"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00775">
        <property type="entry name" value="UPF0311"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
        <property type="entry name" value="UPF0311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315:SF1">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5488548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="160" mass="17824" checksum="D4EEB52E579A8865" modified="2023-11-08" version="1">METLVPPPKLNHLFTLRCAVDPPVEIGTGPYGRRRCVPIKSGSVHGPHFEGEVVPAGGADFMLVEDDQTTHVNTNYVVKSNDGAYLYIRTEGTRAGPPEVLKALMEGGPVDPSQYWFHLHIKIETGHEKYKWMNNRVIVGRATRAKGEVAYDAYYLTNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYV8</accession>
    <name>A0A9X0BYV8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_002441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792003.1">
        <property type="nucleotide sequence ID" value="XM_056932044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYV8"/>
    <dbReference type="GeneID" id="81622293"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF76">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5490874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="55147" checksum="5310447BA4566C82" modified="2023-11-08" version="1">MKRASYPAESLAAWLHLNGVTSNGVKFQRADTGDLSAEKGTAVIATESRVSSMSDAEPTILFRVPADLVLSLETVHDHAKSDQHLREVLDAVGAFGTTTRGAILIFLLLQLTHSSPDITQRIGVSSPWAEYVKFFPESFPLPTFYRGEEVSLLEGTSLSSALNGKVTALEREFEHLRQSTESIPWCQQCWWDADAGRLSIEDWQYVDAAYRSRMVDLPSIGHSIVPCIDMANHTGGGEAKALYDVSSEGSVILQLRWGQGIQPGEEVTISYGDEKPASEMLFAYGFLPDDLADAKQVLLDVTLPEDDPLAVAKNMFCRKNPGLKLSVGGANEGQTDEAASDIHWESQLIWWASVNEEDGLHIGIAQRTDGTKELEARWKDHPIQSCDQLLGFLTADPSWEIFQLRAVMLVLQRVETQLASLHRVSNAIDSIRDDEALMGKLFRPEVMATVSKLRTLEEDLLQRSIQSLINQRNTLVESPAVMSYLTKQSVPEDVEDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ13</accession>
    <name>A0A9X0BZ13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall biogenesis protein Mhp1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:GTPase activator activity"/>
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</entry>
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</entry>
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    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C018</accession>
    <name>A0A9X0C018_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">N7539_001597</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="17">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793231.1">
        <property type="nucleotide sequence ID" value="XM_056931200.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81621449"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF423">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 18" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="968"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1001"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1038"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1121"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1153"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="255"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="20">
        <location>
            <begin position="350"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="21">
        <location>
            <begin position="995"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1247"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1250"/>
            <end position="1267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAJ5492851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1290" mass="139865" checksum="4FFA808C468CB61C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C067</accession>
    <name>A0A9X0C067_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Autophagy-related protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_001894</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="7">During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793528.1">
        <property type="nucleotide sequence ID" value="XM_056931497.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81621746"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903599">
        <property type="term" value="P:positive regulation of autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019460">
        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="10">
        <location>
            <begin position="96"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="11">
        <location>
            <begin position="1058"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="565"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="628"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1165"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1234"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="813"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1063"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="628"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1262"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1289"/>
            <end position="1305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5493148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1305" mass="148045" checksum="6E1933BA4A5DFCD2" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0G2</accession>
    <name>A0A9X0C0G2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_002179</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793813.1">
        <property type="nucleotide sequence ID" value="XM_056931782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0G2"/>
    <dbReference type="GeneID" id="81622031"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="100"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5493433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="426" mass="46576" checksum="336D9FEE0F427208" modified="2023-11-08" version="1">MSSGHLPWAGDDDAASGDASRRFNAIEPLNRLQAAVPLGNHQSNSFDAESLPKTTSDRRRASIISTSLDGDVHLSEKVAEQQEGGHALTGTSAEGETVLYLAYGSNLASQTFRGMRGIKPLSEIPVLIPELRLTFDLPGIPYAEPCFAGTQYRDPDLPNSTEPQSHHDNTSSDIEDDFVSEKAPLLVRTQEMQMAEASRNRWHKPLIGVVYEVTLADYAKIIATEGGGRGYRDVVINCHPFAEGFKPTDPVPDHPDTLPFKAHTLLSPSADDARKKTEAAKRGQSSAAVCTASSSNTSIFSDFGPHMRPDPEYAQPSARYLNLLVTGAAEHDLPVTYREYLSQIHTYSITTVRQKIGKAVFVGLWGPPILTLLAFSKRFAGPDGRSPSWLVNLSNILFAAMWFTYDYFFKPVFGEGERTLGDVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0G3</accession>
    <name>A0A9X0C0G3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_001821</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793455.1">
        <property type="nucleotide sequence ID" value="XM_056931424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0G3"/>
    <dbReference type="GeneID" id="81621673"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TPP-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
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        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
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        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
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        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF11">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
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        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
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        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
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    </dbReference>
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    <keyword evidence="10" id="KW-0456">Lyase</keyword>
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        <location>
            <begin position="8"/>
            <end position="117"/>
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            <begin position="202"/>
            <end position="325"/>
        </location>
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            <begin position="395"/>
            <end position="484"/>
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        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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    <feature type="binding site" evidence="11">
        <location>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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    <feature type="binding site" evidence="11">
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        <ligand>
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        </ligand>
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            <dbReference type="ARBA" id="ARBA00001041"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
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        <source>
            <dbReference type="RuleBase" id="RU362132"/>
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        </source>
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            <dbReference type="Pfam" id="PF02775"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAJ5493075.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="575" mass="63587" checksum="E3C610E923F892BF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9X0C2B5_9EURO</name>
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        </submittedName>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <begin position="43"/>
            <end position="60"/>
        </location>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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</entry>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <location>
            <begin position="218"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
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    </evidence>
    <sequence length="297" mass="33901" checksum="1C481091D364175D" modified="2023-11-08" version="1">MNPCEADPEKIPTTDLYADVPFYGRYCPKPNDFRIDLQHVKSQTTDSLRYWASVVSRCTEEIRIYPADEGGRDVFALGSIIVKSSHLHAREGARYMEIDFSYADANELRAIALAKTVLKDAKVPEIYFAGKINGRQVLVQERLPGVALSVAWPYLSSGQRKSYKEQARKILRQLHTIKPTEKLQARAHVVSDPNILSNGRINPLEGDILFSGTNYDPDMSFMHNDFTESNCIVDNGTIVGLIDWEMAGFFGWKTAGEVHRRIRTPQREHFVNANLREEQLQDMMFWSDLYDDGMPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2L9</accession>
    <name>A0A9X0C2L9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_000904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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        </lineage>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056930508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2L9"/>
    <dbReference type="GeneID" id="81620757"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5495788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="80" mass="9081" checksum="41C1E066C26B1BD8" modified="2023-11-08" version="1">MDFMRDHHIPVSDAEVQSVKMIMCKSNNKGAVSRRMRMGMAEERTRCRYGGIRQPTEACIERAVVVGRVQTPKQSQDLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2P1</accession>
    <name>A0A9X0C2P1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794876.1">
        <property type="nucleotide sequence ID" value="XM_056930583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2P1"/>
    <dbReference type="GeneID" id="81620832"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="622" mass="68112" checksum="08BA7FED4753AD9F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C3A7</accession>
    <name>A0A9X0C3A7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ragulator complex protein LAMTOR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_001055</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LAMTOR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794952.1">
        <property type="nucleotide sequence ID" value="XM_056930659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C3A7"/>
    <dbReference type="GeneID" id="81620908"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001919">
        <property type="term" value="P:regulation of receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028209">
        <property type="entry name" value="LAMTOR1/MEH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13401">
        <property type="entry name" value="RAGULATOR COMPLEX PROTEIN LAMTOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13401:SF2">
        <property type="entry name" value="RAGULATOR COMPLEX PROTEIN LAMTOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15454">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01262">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0519">Myristate</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="81"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5495939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="161" mass="17647" checksum="61DC05C9650D4601" modified="2023-11-08" version="1">MGICASCLGGNRRDSLEPESSRLLDEDPYQTSYNYGSLHAQQANQQPDPESVRREREALDAICQRTSDSVIDIWSLQPQPHLQPQATLPAPVSVSNSPTPSRDPKGVTVVAVDKDNSRPSSGNTAPKHWGEVVVNTNKKRSRQNLKDDGDARDVFGVLKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLB8</accession>
    <name>A0A9W9WLB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">glutaryl-CoA dehydrogenase (ETF)</fullName>
            <ecNumber evidence="11">1.3.8.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_009130</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13389"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid metabolism; lysine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid metabolism; tryptophan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.6" evidence="11"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786102.1">
        <property type="nucleotide sequence ID" value="XM_056938725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLB8"/>
    <dbReference type="GeneID" id="81628975"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000003">
        <property type="entry name" value="glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000006">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000008">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="16">
        <location>
            <begin position="45"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="160"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="14">
        <location>
            <begin position="276"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5469512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="425" mass="46279" checksum="AFFDB9AAB9471078" modified="2023-11-08" version="1">MMNRSLFRAAVRSVQGSRTVAGRRCASSSAVFNWEDPLASAELFTEEELAIQDTARQYCQERLLPRVLDAYRNEDYDRKILEEMGEIGLLGASIEGYGCAGVSTVASGLITKEVERVDSGYRSGMSVQSSLAMTGIYEFGTDEQKQRFLPELAKGKLSGCFGLTEPNHGSDPSSMETVAREHPTQKGTYLLTGSKTWITNSPIADLALVWAKLETTGKIKGFLVERSRCPPGTFETPAIKNKSALRASITGMIQMDDCPVPAENMFPDVEGLTGPFTCLNSARLGIAFGTMGALEDCLARAREYSLERKQFKGNPLAKYQLVQKKLADAATDAAYGTLAAVQVARLKDAGKATPEMISMVKRQNCDRALANSRILQEIFGGNAASDEYHIGRHVANLFVVQTYEGQSDIHALILGRAITGKQAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLP1</accession>
    <name>A0A9W9WLP1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_009325</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786297.1">
        <property type="nucleotide sequence ID" value="XM_056938920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLP1"/>
    <dbReference type="GeneID" id="81629170"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="159"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="408"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="563"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="563"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="576"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="619"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="643"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5469707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="656" mass="72769" checksum="75E3578DA2AAF19D" modified="2023-11-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLV9</accession>
    <name>A0A9W9WLV9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
            <ecNumber evidence="2">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_009195</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786167.1">
        <property type="nucleotide sequence ID" value="XM_056938790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLV9"/>
    <dbReference type="GeneID" id="81629040"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="beta_CA_cladeA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF51">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
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    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="266"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="267"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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    <feature type="binding site" evidence="9">
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            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
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        </ligand>
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            <dbReference type="ARBA" id="ARBA00006217"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00014628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5469577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="354" mass="40438" checksum="7BE765C545B8B12E" modified="2023-11-08" version="1">MTGKMTEDMKRNIATIFENNKKWVSAKKEGDGAFFDKLAAGQTPDYLYVGNSTPWMGVSKRRGMNLLEYIGCSDSRVPANEIMGLEAGEVFVHRNIANLVPNIDLNVMSVVNYAVRHLGVKHIIVCGHYNCGGVKAALTPTDLGLLNPWLRNIRDVYRLHEKELDAIQDETKRYNRLVELNVVESCRNVIKTAAVQQSYRQKQYPIVHGWVFDLQDGLLRDLHIDFEEMLKDVMKIYHLSDNEMHSETSVLMYLLIGKEIIGIGDVKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKTIIFHSPQTSSQQPSFSATALPLKGSYTIPCKLNSPRLVASSTSAIPRNERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WM46</accession>
    <name>A0A9W9WM46_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_009330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="3" key="1">
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            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="81"/>
            <end position="139"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5469712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="177" mass="20252" checksum="26DA87789DC9A0F1" modified="2023-11-08" version="1">MPTTYLSSENRRQYYYRHRTHQLPQKNSDNEIRSFQFSSSSGPLPGNPDFSLKEDWIIVGSRGYGDPRIVEQDSKTVESHPHLRSLYSPGTETPSLHVIGRFDARILPAQTFELTSSCIGSIRFHIFGSHYIPHTKTLTGTVKAFVRAHLFGNGTESEEDWEELDDPPEIYRIVLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQY4</accession>
    <name>A0A9W9WQY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056938419.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
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        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="29"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5471881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="211" mass="23522" checksum="31618AA159856BFA" modified="2023-11-08" version="1">MRHVEAILRGVIGDVEFIYLSASWKDFSDTADTDHRVWGHGDPEFDEIKGLGVSLALVRHTLEKDGPFSGVVGFSSGAAMTATITSLLEQPYRGDVKTGRNVSLEINHPQLRFAICLSGFRLKHVSYKKSFYSSSIKTPTFHTIGTSDAVIDPNRTVDLTNCYEDAQVYQYDGGHYVPQYKEANGLRGDLIPFLQRVMKMPTDDACAEIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WR21</accession>
    <name>A0A9W9WR21_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786656.1">
        <property type="nucleotide sequence ID" value="XM_056938274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WR21"/>
    <dbReference type="GeneID" id="81628524"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5472110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="131" mass="14823" checksum="7CEF47411F6138B2" modified="2023-11-08" version="1" fragment="single">PELETLKERCRKYQGTAKINISQITFPTSLSQYLSEKNVKRLCGIFDMEDCRRLDSANYVSAVVDGPLTCIRMTLIWIFKLASLTDIATRGFQTMVKFKLKPANIEIKQMHASRIDGCRGCQTTKHGGFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WT27</accession>
    <name>A0A9W9WT27_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5474992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056937658.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81627908"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5474992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="88" mass="9465" checksum="6D3A3AD2259FDAA2" modified="2023-11-08" version="1">MSTQSSSIVPPTTGNSFTAFSQNISRNTTSSFQPSASWRPSTTLKISTHLVDGMPPAPPPSPVSFAIDSNSGQFIDQWDEIHRLSLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTC4</accession>
    <name>A0A9W9WTC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolasefamily 71</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_056937806.1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040862669" evidence="1">
        <location>
            <begin position="21"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1046" mass="113296" checksum="A0E78A39D5070FEE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTG3</accession>
    <name>A0A9W9WTG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <strain evidence="2">IBT 30728</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056937824.1"/>
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    <dbReference type="GeneID" id="81628074"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="90" mass="9796" checksum="40D76E3926C637EC" modified="2023-11-08" version="1">MHVTQAENSTSARPSTPFTAHPHQPITTPMETITKLPLVGFNIHQPAASSRTPLDLQFPQPRISTPGHQPPAPCLDRPENQVPILSSHPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTN3</accession>
    <name>A0A9W9WTN3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bis(5'-nucleosyl)-tetraphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_008365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
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        </lineage>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056937965.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:nucleotide metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF3">
        <property type="entry name" value="5',5'''-P-1,P-4-TETRAPHOSPHATE PHOSPHORYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="3">
        <location>
            <begin position="50"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="3">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="2">
        <location>
            <begin position="227"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5475299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="39622" checksum="4CC9C1C65A8B0B7B" modified="2023-11-08" version="1">MKLGLSENLSTLVARRWKAAKDGGHLVFSPTQLSIITTGGIPQTVTQNLTSLGPLKYQLRFCPALAMKPQDSKNNTSAQPKPKKVDPFENPSPDLLIASFPPRDPTHALILNKFPVIPDHFILSTRAWKAQTDILETADLAATHECLRAWGDKSASSQNRPDSSSTSTDRLFAFFNSGEESGASQSHRHIQFLPVEAMRSSAGDSWKPLIDFVTSQPRNRSTFQSHPSLPFTHFALPLPPNPAPETLHSIYTTLYRAAVGAVQGLDPRDGLPSVADHGPSAISYNLAMTLETMMIVPRRSETAHVPVDVSAAGDIADPGLVSLNGTILAGTLMVKAEAEWDVLRAQPDVLGRILRDVGVPGPGHASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUJ8</accession>
    <name>A0A9W9WUJ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5476996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787540.1">
        <property type="nucleotide sequence ID" value="XM_056936741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUJ8"/>
    <dbReference type="GeneID" id="81626990"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF44">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="63"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5476996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="446" mass="50199" checksum="DAADEF3E7E518AC6" modified="2023-11-08" version="1">MSKPLHNHEVPETPGLSPHLHDVLAELHRRPYPHVPNPPRCSRRASVALILRVKPTYQDQPESSRLAVDQSLSVEEQLQSFFSQSWVQHGDPEVLFIKRASREGDRWNGHVALPGGKRDPEDLNDFTVAIRETAEEIGLDLTTDDVISVGNLPERVITTSWGAEPIMVLCPYIFLTTRSDCITLNLQPTEVAAVHWVPLRALLSPSLRSKEYVDMSQRFTRQGGYFSRLVVRSLMGWMQFSAVRLLPSESHLSASTMGFTYDSFRGPVSLWSRFKAWILSNQADSGDPSRPLLLWGLTLGVLADFLDMLPPHNAVALWEYPTFTAPDLRLIVSILTSPLRKYNAQEVRFGYRSPDTAVDSETSALRVTRGDDDANHDPNAVGIGGLGVGRYYGPTDRQGEGSSYAVGIMLRGYYQRLRVAIWVFLAWRMTLGSAAAWTAWRYLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUT0</accession>
    <name>A0A9W9WUT0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">TATA-binding protein-associated factor mot1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Modifier of transcription 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NCT transcriptional regulatory complex subunit mot1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">N7539_007186</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box via its C-terminal ATPase activity. Both transcription activation and repression require its ATPase activity. Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B. The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms the NCT transcriptional regulatory complex with nctA and nctB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787586.1">
        <property type="nucleotide sequence ID" value="XM_056936787.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81627036"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17999">
        <property type="entry name" value="DEXHc_Mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000009">
        <property type="entry name" value="B-TFIID TATA-box-binding protein-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000508">
        <property type="entry name" value="Probable helicase mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000445">
        <property type="entry name" value="Related to MOT1-transcriptional accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000428">
        <property type="entry name" value="TATA-binding protein-associated factor 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044078">
        <property type="entry name" value="Mot1_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 20" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="1320"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="1667"/>
            <end position="1818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="179"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="701"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ5477042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1896" mass="210098" checksum="90DFFF4EC737E237" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUX8</accession>
    <name>A0A9W9WUX8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_007293</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787693.1">
        <property type="nucleotide sequence ID" value="XM_056936894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUX8"/>
    <dbReference type="GeneID" id="81627143"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="68"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5477149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="396" mass="44312" checksum="BBB973B1500F76E1" modified="2023-11-08" version="1">MLDPLGAPPAWLRVLAEPYALALKSPTLSEHVHEVIGSFLFYQFIHSVVSPWLSPILCPRSYPALSPRTKLNWDIHVVSLVQSVVINAAALWVMYSDEERQSMSSGERIYGYTGACGMIQALAVGYFIYDLIVSVQHLKMFGIGMLFHAVSALWVFSLGFRPFLNYYAPVFILYELSSPFLNIHWFLDKVNMTGSRAQWYNGMMLLGVFFCCRLVWGTWQSVIVYQDMWNALQHKWSAASSSPLDTPVNIGAHVFAIRDGDMCVDETCARANAEISRFKDFTAGGVPTWLVLTYVTSNIILNFLNYFWFSKMVDTVLKRFRGPPADSAEAKKIDRKPANFDKLAHDAVLDAASTLKDNEDAALQGEKVSSALDAEVADDLRRRRGDLVADLPGPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV85</accession>
    <name>A0A9W9WV85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">T-complex protein 1 subunit theta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_007458</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787858.1">
        <property type="nucleotide sequence ID" value="XM_056937059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV85"/>
    <dbReference type="GeneID" id="81627308"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="7">
        <location>
            <begin position="170"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5477314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="379" mass="42583" checksum="C71B98FEB11C0AAA" modified="2023-11-08" version="1">MLRQAFASLCTAQASPPSLVSASHHLRIRPRISHLAPQVASRWTSTRSPLPSTRSLPNYSLYKALPYRRNFATSFPRQARNTYNRFNPSSARPSVFYTLISRSRPHHFVLIGLGISGVYLYNTEVVEMTGRRRFNCVSHEAELKMGMQSYREVLAQSQGRILPDNHPVAQMVNRVLQRLIPQAPIEGADWRVHVIVDDSNANAFVLPGGKVFVYTGILPICQDEDGLAAVLGHEIAHVVARHPAERMSNSFLTLGTVFLISLLFDVSGQLSSMLVNLMWSLPNSRTQEAEADNIGLMMMAKACFNPEAAVRLWHRMQQQEKSAPPQFMSTHPSSYNREESIRGWLDKAETIYADSGCSTFGSYMPSFKKAYETQSSYGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVJ9</accession>
    <name>A0A9W9WVJ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788023.1">
        <property type="nucleotide sequence ID" value="XM_056937224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVJ9"/>
    <dbReference type="GeneID" id="81627473"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="94" mass="11504" checksum="0AA499F4ED1C7BF4" modified="2023-11-08" version="1">MLGKRGCYPMHGLWIATNATLVVGHLDAVRPLSGARRMIRSLWSPVLVAYYYYYYYYYYYYYYYYYYWTLTVLRDLPNLPFPPAQMSIHKPYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVR0</accession>
    <name>A0A9W9WVR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787710.1">
        <property type="nucleotide sequence ID" value="XM_056936911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVR0"/>
    <dbReference type="GeneID" id="81627160"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF10">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="60"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="154"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="281"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="349"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5481031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="405" mass="43211" checksum="D02E962CA0A8FEB3" modified="2023-11-08" version="1">MSFQNFDTFPNQDAAAAGGAPPQADTTMTGQPDNNGAPFQGAAGDAASASGPQQGADGKTTLWMGELEPWIDENFIRNLWFQMGEQVNVKMIRDKFSGSNAGYCFVDFASPAAAAKALSLNGTPMPNTNRVFKLNWATGGGLADRSRDDRGPEFSIFVGDLGPEVNEYVLVSLFQSRFPSCKSAKIMTDPISGMSRGYGFVRFSDENDQQRALTEMQGVYCGNRPMRISTATPKNKGPGVGAANMGGMPGPAGMYPPMGGPPMGFYGAPQPMNQFTDPNNTTVFVGGLSGYVTEDELRSFFQGFGEITYVKIPPGKGCGFVQFVQRHAAEMAINQMQGYPIGNSRVRLSWGRSQNNSGPAGSPYRPAPPPPPMYPSMGMPPTHQYGGFAPMKVSSHPGSPAPELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2G1</accession>
    <name>A0A9W9X2G1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788648.1">
        <property type="nucleotide sequence ID" value="XM_056935724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2G1"/>
    <dbReference type="GeneID" id="81625973"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5482676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="75" mass="8117" checksum="3DCEAE64D98BDA22" modified="2023-11-08" version="1">MSMTVPGSTMKTKRHGCYSYFALLRVTDPRSRSVSGAATACSAVERSESIFVLATTKAEGFSFEPIVIKSPRQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2M2</accession>
    <name>A0A9W9X2M2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dehydrodolichyl diphosphate synthase complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_006147</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788673.1">
        <property type="nucleotide sequence ID" value="XM_056935749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2M2"/>
    <dbReference type="GeneID" id="81625998"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5482701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="407" mass="45141" checksum="A42FA18928EB1CFA" modified="2023-11-08" version="1">MSGSMHLSRLRRWFLASPPIEFAINNLKELLVGALRQGPIPQHVAFVMDGNRRFARCHGIETVEGHNLGFEALARILEVCYKSGVKVVTIYAFSIENFKRSKFEVDALMDMAKVKLSQMAQHGDLLDRYGAQVRVLGRLDLLKPDVLAAVNKAVDLTSRNGDRVLNICFPYTSRDEITTAIRDTVRDYSTPLRSDPPANGISRTPFSESHITHHIRAQARCSSKVPDPQSDSESSSAESSALDDDSSSRNDSASRIYESGSSFSSSTTLHLGPQDGHHTKGAALGHPSDTETPSFLSPETISRHILTENMLTKGTPPLDMLVRTSGVERLSDFMLWQCHEATEIVFLDVLWPEFDLWHFLPVLLGWQRRISKSRQNPNGEGDFAGDSPEGKGQLDNIVMLGNKLKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X311</accession>
    <name>A0A9W9X311_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="14">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_006765</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="14"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788301.1">
        <property type="nucleotide sequence ID" value="XM_056936366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X311"/>
    <dbReference type="GeneID" id="81626615"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000015">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
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        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="527"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="555"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="591"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="615"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="644"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="682"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="721"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="746"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="771"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="842"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="881"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="916"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="947"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="16">
        <location>
            <begin position="143"/>
            <end position="315"/>
        </location>
    </feature>
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        <location>
            <begin position="453"/>
            <end position="940"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1000"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1008"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5480871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1024" mass="113405" checksum="E49F2F0DCC05D41D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X4Y7</accession>
    <name>A0A9W9X4Y7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_005712</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789186.1">
        <property type="nucleotide sequence ID" value="XM_056935314.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81625563"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
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        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="15"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5483916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="340" mass="36724" checksum="A2CF36E603CDDA43" modified="2023-11-08" version="1">MPSTMRAIAIKGGKGPAEAMHMAEIEKPVPAAGQALVKIRAFGLNRMDLLQREGQYPLPPQAPETMGVEFSGVIEGFGGDADKSGDFKRGDEVFGLAYGGAYAEYIVVSTKMLVHKPSQLSWEEAAGVPETWITATQALFLIGEFKKGQSVLWHAGASSVSISGIQLAKAEGASAIYATAGSQEKIDFLEKELGVTKAFNYNTEDWASEIQKLTGGSGVNVIVDFIGAPYFQGNLNTAARDGRVVVLGIMGGGKLPEGVNMAPLLFKRVRLEGSTLRSRDEEYQGKLRDTLVEHALPKFCDGSFKVFVEKVFSFEDIVQAHQLLESNKTKGKLICKVGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X561</accession>
    <name>A0A9W9X561_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ergosterol biosynthetic protein 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_005863</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789337.1">
        <property type="nucleotide sequence ID" value="XM_056935465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X561"/>
    <dbReference type="GeneID" id="81625714"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5484067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="136" mass="15053" checksum="B119F3619505D42F" modified="2023-11-08" version="1">MEQLLSYLPPFEGLLPKWLVFVSVVSAVNSLQAYSSADYTSKLYTNGALVLDSLSGRVFGTWTFLSAVIRMTAAYNMDSPIAYNLAMWTYGIALVHFTLELVVGNASLRGRFLSPLLVASGSLAWMFSQREAYLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5B3</accession>
    <name>A0A9W9X5B3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="1">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_005938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789412.1">
        <property type="nucleotide sequence ID" value="XM_056935540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5B3"/>
    <dbReference type="GeneID" id="81625789"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054491">
        <property type="entry name" value="MGH1-like_GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF10">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 63 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22422">
        <property type="entry name" value="MGH1-like_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="3">
        <location>
            <begin position="450"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="933"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="950"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="991"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5484142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1046" mass="121898" checksum="7A87CCA18E5F012E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5H3</accession>
    <name>A0A9W9X5H3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789518.1">
        <property type="nucleotide sequence ID" value="XM_056934324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5H3"/>
    <dbReference type="GeneID" id="81624573"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="707"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5484734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="959" mass="103296" checksum="631A42587ACEB002" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5K1</accession>
    <name>A0A9W9X5K1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_004705</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789501.1">
        <property type="nucleotide sequence ID" value="XM_056934307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5K1"/>
    <dbReference type="GeneID" id="81624556"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001156">
        <property type="entry name" value="Zinc finger protein 407"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5484717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="352" mass="36596" checksum="3DE15230F52BFCA0" modified="2023-11-08" version="1">MTALAVPAVPGPGMGTSLEGLSSQPLNSRRPAAPTLPSFELPPPPFGLAVGAHGQCDLLGPQFVLPVESPSVRVGDFPPTTDGLSQPYEAPPMASFSQALPAPSTSTLASGPHPVTLGLYQPNHTASAASLPSNDPYNSKVHSMYASPGQHTGYSPLYAGPNPLGGHGHPGMHPGARMPLQSPGGQPPVPYPRQPWPSYSLPAMSGPVMSNVHSPNSPLSMMGGMPSGVLPGFNSGHLANTQHLYGAHSASHHGMPGPVADRPFKCDQCPQSFNRNHDLKRHKRIHLAVKPFPCAHCDKSFSRKDALKRHILVKGCGTATASDSNGALTGENGTLKIEGSGDDLSPLANGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5U1</accession>
    <name>A0A9W9X5U1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789636.1">
        <property type="nucleotide sequence ID" value="XM_056934442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5U1"/>
    <dbReference type="GeneID" id="81624691"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5484852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="59" mass="6198" checksum="682AB63A72576381" modified="2023-11-08" version="1">MSGTWSPSITSLARITRPPGSKQSTYHSMQSCTGGGTFNGQQGHTCMPDPAGAERKSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5U6</accession>
    <name>A0A9W9X5U6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_004902</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the RBR family. RNF14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789698.1">
        <property type="nucleotide sequence ID" value="XM_056934504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5U6"/>
    <dbReference type="GeneID" id="81624753"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20354">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23134">
        <property type="entry name" value="RING-HC_ITT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23820">
        <property type="entry name" value="RWD_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000024">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000112">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000416">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047548">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RWD" evidence="14">
        <location>
            <begin position="12"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="194"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="198"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="320"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="503"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="588"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5484914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="643" mass="72531" checksum="D17E091D4BCA5DCE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5W3</accession>
    <name>A0A9W9X5W3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_004815</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789611.1">
        <property type="nucleotide sequence ID" value="XM_056934417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5W3"/>
    <dbReference type="GeneID" id="81624666"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="30"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5484827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="310" mass="34341" checksum="96F96B35B6D031A0" modified="2023-11-08" version="1">MTTGTAQDQGPKILVVCWILVIVPGLIVGLRFYCKVMLSRGFGWDDATILVAWTLQLIYTAMITQSVKLGVVGKHVNSIPAREAIPEALKLVYISFVIIIIGCVLSKTSFALTLLRIITKTWMKVLLWYIIISMNAIMWLCAICYLIQCSPTAALWDIRLMKTANCWPTIVFEAIALAAGVFLVLASTQSRLMFNFTLSLFWSHGRGSRSSSLARDLEIADATPRKVRHCAGNEHGDIVRSLRRQNSSINAETNSKRSASITAFIKTSQLVNVAHLHDFTCTPKTHFPPHTQFPTVSLLSDGPSNESSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X698</accession>
    <name>A0A9W9X698_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789866.1">
        <property type="nucleotide sequence ID" value="XM_056934672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X698"/>
    <dbReference type="GeneID" id="81624921"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039870">
        <property type="entry name" value="Coa4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="9061" checksum="24F292FF0DC95C43" modified="2023-11-08" version="1">MSNSAQQQSSIDLEDDDEPSDWDKRIYSTGCHAEQDKMNDCYFVKKDWRACSKEMEAFRECWKRKGNDQRTETKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6F3</accession>
    <name>A0A9W9X6F3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_005202</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789998.1">
        <property type="nucleotide sequence ID" value="XM_056934804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6F3"/>
    <dbReference type="GeneID" id="81625053"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF1">
        <property type="entry name" value="PROTEIN YIPF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="163"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5485214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="300" mass="32336" checksum="5C448A378383689B" modified="2023-11-08" version="1">MASVQPGHSQGDLLDDESLLDDDLIEADHDIEADDPLHTSDTAPLRGNIAPESSSQGTRADGYGNYLTSSIPGEDRRATQNTIDESVWETLSRDLIAVWEKMRQVLWPKYLLGGMLQRGGGGMGDAAERGEAMTGFGRNLRGLVGRWPDADMVLQGGMSEGLRDWDLWGPLVFCLILSLFLSIAKGDQASNVFSGVFCIVWIGEAAVTLQIKLLGGKISFFQSISIIGYTLFPLVIAALLSALRLPTIARIPVYLVLVAWSLAAGVSILGGSGVLRNRVGIAVYPLFVFYIAIGCLCFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6X4</accession>
    <name>A0A9W9X6X4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_005395</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790191.1">
        <property type="nucleotide sequence ID" value="XM_056934997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6X4"/>
    <dbReference type="GeneID" id="81625246"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="38"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5485407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="532" mass="58730" checksum="BE1B2856ECA56FFC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X746</accession>
    <name>A0A9W9X746_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTPase-activating protein GYP7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GAP for YPT7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_004888</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789684.1">
        <property type="nucleotide sequence ID" value="XM_056934490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X746"/>
    <dbReference type="GeneID" id="81624739"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000032">
        <property type="entry name" value="GTPase activating protein (Gyp7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000005">
        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="434"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="251"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="735"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="757"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00072091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00082648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5484900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="806" mass="92411" checksum="C1B422C1A781C878" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCF6</accession>
    <name>A0A9W9XCF6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_003624</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790767.1">
        <property type="nucleotide sequence ID" value="XM_056933226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCF6"/>
    <dbReference type="GeneID" id="81623475"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="119"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5488734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="598" mass="66270" checksum="F3D60258A79F0CEF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XD35</accession>
    <name>A0A9W9XD35_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BCP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_003954</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Involved in nuclear export, actin cytoskeleton organization and vesicular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the BCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791097.1">
        <property type="nucleotide sequence ID" value="XM_056933556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XD35"/>
    <dbReference type="GeneID" id="81623805"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028983">
        <property type="entry name" value="BCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5489064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="289" mass="32431" checksum="72C92A25258115CC" modified="2023-11-08" version="1">MGKRKQDLGDVPMGGTGANDDDSDDDVDMVNVEFEWFDPQPAVDFHGLKNLLRQLLDNDAQMFDLSALADLILSQPTLGSTVKVDGNESDPYAFLSVVNLQEHKDKPVVQSLINYFREKAAANPALSPLKDLLSQNPVPPIGLILTERMINMPTEVIPPMYNMLVEEIAWAIEDKEPFNFSHYLILSKNYVEIESKLDMEESRPQKKKKKGGEAAPRFFFHPEDEILERHAICSGPVEYTHKQDEGHSDSKRAFQELGVQTNGSLILIDGTKFESTVKALIEYVKPPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XD49</accession>
    <name>A0A9W9XD49_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_004016</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791159.1">
        <property type="nucleotide sequence ID" value="XM_056933618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XD49"/>
    <dbReference type="GeneID" id="81623867"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF16">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5489126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="418" mass="47195" checksum="80A5FC02B69DDFCC" modified="2023-11-08" version="1">MRLNFSAPGTPTLSRQSTFTQGRHHQRRLTHPHLLSSRRKPRRWPLVFRFVKGAIHAQILMSVLLHALFTAFVVYLDNHVFETVVLPPSIIPSLSIVVGLMLVFRNQTSYNRFWDGRNAMSTMNTCLRNLTRTIVTNSYSSTRGPPNLMEREDIERTLRVLIAIPFAVKNHLRAEWGAAWATDSTHGGPFDERGTAAYNPDYAGLLPAGLEGHEYEGLGLPYQLTYFVDGFIKRGEDRGWFNAPGASQMQAQLNTFLDAYGRMETIKLTPMPVAHLIHQKQVLALFGCVLPFAMVDQMGWWAIPIVCLVIFTLYGIEGIGSQLEDPFGYDRNDIKMDALVGDTKIELDVVVNEWRTYSKAMEGAWRAADNVNGHGERCLDGAPKATNAANQGQNTREKYHPPDLFIRRRPQVTVEDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDI3</accession>
    <name>A0A9W9XDI3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790906.1">
        <property type="nucleotide sequence ID" value="XM_056933365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDI3"/>
    <dbReference type="GeneID" id="81623614"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="338" mass="37879" checksum="BB19F3866FB3B346" modified="2023-11-08" version="1">MSLQKQEKRPDGLSTYLKRFETAFLTRPASKRPPSIADSTTTSNLPSNRPVPTLTSTAEPNPLSAEEPIDVDRIIAQRERARALLARYGLHLGPEEVNPSSDIQFPRVNRTIRIRVRRTCHRCETAFGPNTVCINCQHPRCKSCPISPVNNEHDDKCAYVSHAKVFELCARRPGTLPMTPHLKFTGNPAAPLTMQSRIGGPDHLRKPVVQRVRRMCHSCDTMFEPGSKECGSCAHVRCKKCPRSPHRPEKYPNGYPGDVEPPTRKPERTFRKPRQRVHCICHVCHATFNDGASTCGKCGQAKCAETVRNPPKKVKTEPDSTILRRVEDRITLLADIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDY9</accession>
    <name>A0A9W9XDY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_004520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791663.1">
        <property type="nucleotide sequence ID" value="XM_056934122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDY9"/>
    <dbReference type="GeneID" id="81624371"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5489630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="404" mass="45979" checksum="75363775B4EA8E53" modified="2023-11-08" version="1">MGSFTLNTFPGKLSLTQEPPINYQMHIKPMDWSTNTDITTCAPHEPNPLRRSRCEGDSLAYDAFWASRHPWDLVDYYLFLILIEKKLQHREIRLSRSWVIESDGSRCENFGRIIDSDDQMCQVGWVDPIVIFTSLPVPHAVGFENRRIALGMNLRSQSLVGYLLDSAPEDITEVVLSPAWEDREVLIDLPLQRFVDILGHSVEPGQKPGEILREGLLNYFRESSRRLHAGMDLVIVIQFIQFLRDAFFGGQMSAGIDYNATTECLSYLVEQEEHLRDILCRESNRAWMGAHTGVTVNDLHRRGQTPSEPLYDLFVDQVVASPIVNEFSFGAARMLPVQDTSAVLKSQIRVTTTSWFDSTDMISLNEDTVSECDSTRQLTSNIVVLLGLFCSECTWMMGSERWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFD5</accession>
    <name>A0A9W9XFD5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791847.1">
        <property type="nucleotide sequence ID" value="XM_056931888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFD5"/>
    <dbReference type="GeneID" id="81622137"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041018072" description="Hydrophobin" evidence="2">
        <location>
            <begin position="17"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5490718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="153" mass="15227" checksum="E26E34D702B84A33" modified="2023-11-08" version="1">MKFIATALLFAAATLAMPSAPCDKDGKHSDGSSDDSSNNITYEQASAKCGNDAVVSCCNKETVTGSVTSVNNGLLAGVLSNAIAGGPGSDGLGLFNGCSDLSLGVPVASLLSAQNILNKKCQQSIACCQNSRSEANGDLVGVALPCVALGSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFM7</accession>
    <name>A0A9W9XFM7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_002928</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792490.1">
        <property type="nucleotide sequence ID" value="XM_056932531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFM7"/>
    <dbReference type="GeneID" id="81622780"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] cytochrome b small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5491361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="164" mass="17987" checksum="77C38BE899ACE949" modified="2023-11-08" version="1">MASFARSSLVRQSLAANRSPLLRQNVGVSQVVAFHASARKQILPPLPLNDPVPTPAPHPVEGSYHWTFERAVSVGLIPLTIAPFAAGSLNPVMDAVLCTLLVAHSHVGFQAAIIDYFRPQRVPKFSSFCHWLLRAFTLTTAVGLYEFETNDVGVTEALRRIWNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFZ6</accession>
    <name>A0A9W9XFZ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003132</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIase H subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792694.1">
        <property type="nucleotide sequence ID" value="XM_056932735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFZ6"/>
    <dbReference type="GeneID" id="81622984"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000035">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5491565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="179" mass="19671" checksum="B9ED75135777F3D7" modified="2023-11-08" version="1">MTSIQPIEPTNPVVFFDLALGSEPLGRVKMELFAHVTPKTAENFRQFCTGESKNPKGQPQGYKGSKFHRVIKDFMIQGGDFVNGDGTGSCTIYGTTKFADENFALSHDRPGLLSMANSGPNTNGCQFFITTVATPFLNNKHVVFGQVIDGMDIVKMVEQTRTTRDKPNQDVTIVQCGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGE1</accession>
    <name>A0A9W9XGE1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 55</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_003254</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792815.1">
        <property type="nucleotide sequence ID" value="XM_056932856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGE1"/>
    <dbReference type="GeneID" id="81623105"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5491687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="128" mass="13908" checksum="A07CD6BB3C244E5C" modified="2023-11-08" version="1">MAAGLKTIIALSFVLAIGFLLVILSSALWHKYWPLLVVAIYVVAPLPNWICARCANPDDFMDSSSSSAMDFGRFMTGFLVLTGIALPVVLAHSGAIEIPAMIMSIIGGLLIYGTIISFSMFFQEQEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGT4</accession>
    <name>A0A9W9XGT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_001468</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793102.1">
        <property type="nucleotide sequence ID" value="XM_056931071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGT4"/>
    <dbReference type="GeneID" id="81621320"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF112">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5492722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="336" mass="37031" checksum="3F9B4290F4530213" modified="2023-11-08" version="1">MAFILRRPFAVSTALKEVPKFSNTARFIHNSPFKSSPAIKPLAAQPSFFSKSHQPLRNAFRRSYMQQTYNAQGGNFTQKLLYGGAIVGGTILATNFIFNRETREDGGMPAYERSFLNETFMHTGLGIGIIAIAARALHTSGWSVRLMSMNPWLVMGVGLVGSIGSMYATFATPPDNYLLKYGCWTMFNLTQAALLSPLMFMHPAILARAGLYTVGMMGSIAFVGATAKQEKYLYLGGPLLAGVALVALSGLAPMVLPATAARTLMWSERVWLYGGLAVFGGFTLYDVQKVLHHARLAERGYMKRDVVNESVSLELDFINIFIRMVQILGMRSNNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGT7</accession>
    <name>A0A9W9XGT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TMEM205-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_001344</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792978.1">
        <property type="nucleotide sequence ID" value="XM_056930947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGT7"/>
    <dbReference type="GeneID" id="81621196"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053009">
        <property type="entry name" value="Xanthocillin_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241:SF106">
        <property type="entry name" value="DUF4149 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PLANTS LEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="6">
        <location>
            <begin position="10"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5492598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="197" mass="21796" checksum="6A58C3C432BDD26A" modified="2023-11-08" version="1">MTDPRPYHVLSYGTLLGTQVFQTSQSFVGGIVAFRALPRPQFATLQTAIFPVYFSMQTALPIVVALTASRQGQALGLPGLLAPENRMNTLLPMATVAITGLINMFVLRPLTVKTMRERKHQGKLLSPLSPDLRSFSYKILAPETRDGKKSYDAPPHSKEMMALNKKFGRIHGLSSMVNMVSFIATVWYGAILSKRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHA5</accession>
    <name>A0A9W9XHA5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793376.1">
        <property type="nucleotide sequence ID" value="XM_056931345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHA5"/>
    <dbReference type="GeneID" id="81621594"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016150">
        <property type="term" value="F:translation release factor activity, codon nonspecific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052104">
        <property type="entry name" value="Mito_Release_Factor_mL62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075:SF54">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="1">
        <location>
            <begin position="67"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="199" mass="21799" checksum="6C843BD7E2840567" modified="2023-11-08" version="1">MRLRPQWYTRAGWRDTPSLVFARPSVPRVGGQAAKFASARSSDPLDPQDVELARTWLKAFQSGAQSIPRQLGQISFSRSSGPGGQNVNKSVQALIHLHLLPSHCSLGAIRNVVNSKATLKVPLSALFPLVPPLLHPQLRASRYATERSQALVIQSDESRQQSTNVDACYAKLNQLLISSARDTIPGVTSQVQKDRVTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHE9</accession>
    <name>A0A9W9XHE9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_001802</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793436.1">
        <property type="nucleotide sequence ID" value="XM_056931405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHE9"/>
    <dbReference type="GeneID" id="81621654"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF61">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5493056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="679" mass="76545" checksum="21FC1B37CA69C6D4" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI04</accession>
    <name>A0A9W9XI04_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAR-17a/AIG1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793748.1">
        <property type="nucleotide sequence ID" value="XM_056931717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XI04"/>
    <dbReference type="GeneID" id="81621966"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242:SF1">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32342" checksum="0189683F053A964A" modified="2023-11-08" version="1">MTISWARLFGADPSLDNLHRFETSWLLSPMALAGVRALTTLYIFTTIFTIWGWYGSHDDSSAIGQSFSYFTWLTYWGLGFYHLTATIHTVLYARTGRSVLLDRWPRVFRVLHVLFYATITTFPFLVTIVFWAILFKAPFYKEIFPGWSNISQHGLNSLHALVEIILPATAPHPWMAIPVLVLLLLFYLCVAYITHATSGFYTYSFLDPGVDGHKSGLVTGYCFGILVAILILFLVSWGLIRLRVYLTGDRIKRAARDPLRHGPGDFDNATRLRDASMEMKQASAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI33</accession>
    <name>A0A9W9XI33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription elongation factor Eaf N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793653.1">
        <property type="nucleotide sequence ID" value="XM_056931622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XI33"/>
    <dbReference type="GeneID" id="81621871"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019194">
        <property type="entry name" value="Tscrpt_elong_fac_Eaf_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09816">
        <property type="entry name" value="EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription elongation factor Eaf N-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5493273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="402" mass="43603" checksum="7ADED1EFDC03B15A" modified="2023-11-08" version="1">MSTMIDPTKQAEYPIVLGNRLAKNTASGRLVNVNYNYKSKSATPQQRSKITRSTLSRDLYDLSVTDKPSNADHTITYSYVGSEDPSGDQSLVLVFDPERKVFVLEPVSTKLNFNLRSAPGKTEKQVLEQYEQLRISHEGDNTSTADHNGGNETEDEGPADESNPYDFRHFLPKEGAEDPKVPSRTSTPEPSNTSKTGTPNLPPSRPTVKTAPQPRAPKAPANPLREVKRVQKPPVKPKVAREKPADQAPEPVPPKDLPTERDESRMSESDAGTANGSQQSVQSPGSNIIIDGELIIDMGSPPPKRAFKVNPSFFSSNNTPSDDQEANDSEVDIDSGNSTCPPAGSVGTGDDMEEDDDDALAAEMEAAFEASAREEEALGHRYGEGNYIVGMGSDESEVSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI63</accession>
    <name>A0A9W9XI63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_002095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793729.1">
        <property type="nucleotide sequence ID" value="XM_056931698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XI63"/>
    <dbReference type="GeneID" id="81621947"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5493349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="145" mass="15530" checksum="F183A59AD1662C79" modified="2023-11-08" version="1">MGDGRMYEALSVGLVRVVGALAPIWQSGGVRPPQDHCQQAVVVNAFNPGSFQTKLPDMMHLPEVLDSAMIYSGTFVPRSSMDGAAFDRIFYSRSPIGYLASSPALEPAVASGSDLSCTGNPASLKLVQEKMESSRVGKYFDLTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIA3</accession>
    <name>A0A9W9XIA3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Deoxyribodipyrimidine photo-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_002247</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793881.1">
        <property type="nucleotide sequence ID" value="XM_056931850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIA3"/>
    <dbReference type="GeneID" id="81622099"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000003">
        <property type="entry name" value="Deoxyribodipyrimidine photo-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF18">
        <property type="entry name" value="SI:CH1073-390K14.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="9">
        <location>
            <begin position="93"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="345"/>
            <end position="349"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="387"/>
            <end position="394"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="485"/>
            <end position="487"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="472"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5493501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="584" mass="67185" checksum="F00F50A67101797B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XL17</accession>
    <name>A0A9W9XL17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793965.1">
        <property type="nucleotide sequence ID" value="XM_056929672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XL17"/>
    <dbReference type="GeneID" id="81619921"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF5">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040884235" evidence="2">
        <location>
            <begin position="23"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5494952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="303" mass="33531" checksum="705AF0790CB76EAE" modified="2023-11-08" version="1">MHYSIALLPSSMVALLCGTTFAAGPAPSELQSILKNTHNSKDYGYPTDITRDLHPLWPGLSKGCTSTEADVWLYNDTLYVGHDQSSLTKERTLQSLYINPILDILERQNPTSPFVTEPTRNGVWDTTPDQTLYFFIDLKTSGPETFKAVVKALEPLRQKGYLTTLHGGRNLTNGPVTVIGTGNTPLNMVAHVSDRDYFFDAPLPALNDAEYSNITKFVSPIASTDFAAAVGRITSDTDPVLNNSQVMVLRDQIALARSRGIGARYWNTPSWPVRTRNLVWRTLLREGVALLNVDDLDAVLTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XL32</accession>
    <name>A0A9W9XL32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_000070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793967.1">
        <property type="nucleotide sequence ID" value="XM_056929674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XL32"/>
    <dbReference type="GeneID" id="81619923"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032931">
        <property type="term" value="F:histone H3K56 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016849">
        <property type="entry name" value="Rtt109"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF2">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE RTT109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01250">
        <property type="entry name" value="KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51728">
        <property type="entry name" value="RTT109_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="330"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="500"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5494954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="552" mass="60204" checksum="05C0B8457E0A2E41" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XL92</accession>
    <name>A0A9W9XL92_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Probable electron transfer flavoprotein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_000158</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </cofactor>
        <text evidence="7">Binds 1 AMP per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794055.1">
        <property type="nucleotide sequence ID" value="XM_056929762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XL92"/>
    <dbReference type="GeneID" id="81620011"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="8">
        <location>
            <begin position="27"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5495042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="261" mass="27939" checksum="AACD1B7E3C4D688A" modified="2023-11-08" version="1">MASGLRILVPVKRVIDYAVKPRINKAQTGVETAGVKHSLNPFDELSIEEAVRLRERKGPLKVENILALSAGGPKTPDVLRTAMAMGADRAFHIDVGDSADGGPEPLTVAKMLKAVVEKENINLVLLGKQAIDGDQGQTGQMLAGLLGWPQATQASKVDVKDEAGTVEITHEVDGGVETLRAKLPLVITTDLRLNEPRYASLPNIMKAKKKPLEKKTLADLGVEDTRRLKTLKVTEPPARTGGGKVEDVDGLVSKLKELGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLV4</accession>
    <name>A0A9W9XLV4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosome-interacting GTPase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_000542</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794439.1">
        <property type="nucleotide sequence ID" value="XM_056930146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLV4"/>
    <dbReference type="GeneID" id="81620395"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="65"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="292"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5495426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="368" mass="40966" checksum="751F8965EB378096" modified="2023-11-08" version="1">MVNITEKIKEIEDEMRRTQKNKATEYHLGLLKGKLARLRAQLLEPAGGAGSGGGSGFDVSKSGDARVALVGFPSVGKSTFLSKITKTKSEAASYSFTTLTAIPGVLEYAGAEIQILDLPGIIEGASEGKGRGRQVISAAKTSDLILMVLDATKRAEQRALLEAELDAVGIRLNKEPPNIYLKVKKAGGMKITFQTPPKVLDEKIIYNVLRDYKILNCEVLVRDENATIDDFIDVIMKDHRKYIRCLYVYNKIDSVSLEFLDQLAREPYTAVMSCELDLGVQEVVERIWKELRLMRLYTKRKGEEPDFSEALIVRQDSSIEDVCDQIHRTLKETFKYAMVWGASARHVPQRVGLGHMVADEDVVSIVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM45</accession>
    <name>A0A9W9XM45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_000677</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794574.1">
        <property type="nucleotide sequence ID" value="XM_056930281.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81620530"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="6">
        <location>
            <begin position="1893"/>
            <end position="1988"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1324"/>
            <end position="1366"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1328"/>
            <end position="1366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5495561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="2076" mass="228648" checksum="FBEA2DA0FCA03C8F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMB0</accession>
    <name>A0A9W9XMB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isonitrile hydratase-like protein xanA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793912.1">
        <property type="nucleotide sequence ID" value="XM_056929619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMB0"/>
    <dbReference type="GeneID" id="81619868"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF3">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR RV1931C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="DJ-1/PfpI" evidence="2">
        <location>
            <begin position="12"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5494899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="235" mass="26122" checksum="81C4EA68CA9BF3E3" modified="2023-11-08" version="1">MSHLTDKQYYHVGVLLFPGVDILDFAGPMEVLSHALHNRNPDEPDRMFLFITIARTSFIQAASSFTIKVDVLLDEALTRISQYDILIVPGGPPSVIQPLTDSNIPEVRFIRTFAHLPAPVCPQRPRILFSVCTGALLVGATGVLSGLTVTTHHRALDTLRQICEKFREKNRPPPEVVLWRYVDGGCLGENSLRVITAGGVSSGLDASFYLVRLLTDSEMAAFISRVMEYDWKELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMN2</accession>
    <name>A0A9W9XMN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Multicopper oxidase abr1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_000421</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794318.1">
        <property type="nucleotide sequence ID" value="XM_056930025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMN2"/>
    <dbReference type="GeneID" id="81620274"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000071">
        <property type="entry name" value="Conidial pigment biosynthesis oxidase Abr1/brown 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040999849" evidence="7">
        <location>
            <begin position="22"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="30"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="152"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="368"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="567"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="632"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="706"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="596"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="655"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="717"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5495305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="764" mass="83780" checksum="954F2C0AC03BE267" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMP2</accession>
    <name>A0A9W9XMP2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrogen metabolite repression protein nmrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_000436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794333.1">
        <property type="nucleotide sequence ID" value="XM_056930040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMP2"/>
    <dbReference type="GeneID" id="81620289"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF5">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5495320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="352" mass="38698" checksum="60C2C0C5DD89DE70" modified="2023-11-08" version="1">MTQPQKTIAVVNAAGRQAASLIRVASAVGYAVRAQIHSLKGLIAEELQTLPNVTLLQGPLLDNPALMDTLFRGAHYAFINTVSQAGDEVAIGRALADAAKRAGSITHYIYSSMPDHSVHGPWPAVPQWAPKFTVENYVRQLGLPATFVYAGIYNNNFTSLPYPLFQMELMPDGSFEWHAPFDPETPLPWLDAEHDVGPTLLQIFKDGPKKWHGHRIALTFETLSPNQVCAAFTRALNRPCRYVRVPKIEIKVKIPPGYREQLEALEVLFGAYNAPYFPQPEFSQPAAGSPKGIGPAGGKGAGAGMMQGPGGVVSLRVTDEARHLWQGWRDMEEYAREVFPVEEEANGLDWML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMW7</accession>
    <name>A0A9W9XMW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_001032</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794929.1">
        <property type="nucleotide sequence ID" value="XM_056930636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMW7"/>
    <dbReference type="GeneID" id="81620885"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF252">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="53"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5495916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="451" mass="48710" checksum="9819713307D28754" modified="2023-11-08" version="1">MNEKAASCSIPNSNERVDNDRQLSPSPPLGLPPPSVQLDDHESMIDGGTVAWMNVLAGFCVFVNSWGVLTTFGAFQEYYQTELLTDQSPSSISWVGSVQATLIPMVGIISGPLVDSGHVRPLITMGSFLTVLGLMMTSIATRYYQVLLAQGFCVGIGGGISYIPALTMVSTRFTTRRPIAIGIASVGSSVGAVVFPVMFRQLQPRIGFPWAVRSIAFVALLTGLIACVILCRQHPPKTRARSLIDWTAFGEWPFMLLSVSLTCVMLAYYVPIFYIASYARTVVHTTTSLSFYMVAIVNGSSVIGRIVPYLLVRYVNPMTIVILGVTGSAIAMFTWVAVSDLPGFIVWACYWGSLSGILVTGPTSILAHPVFCPDIKYIGTRLGMMWGISSLGSLAGTPIAGALVNLETANFLHAQVFAGCVMVGAVSLQLWPFVQTRLYDRNHRPSPSQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN10</accession>
    <name>A0A9W9XN10_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_001138</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795035.1">
        <property type="nucleotide sequence ID" value="XM_056930742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN10"/>
    <dbReference type="GeneID" id="81620991"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="405"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="859"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5496022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1035" mass="115487" checksum="426B996C06F4FEBE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XNG2</accession>
    <name>A0A9W9XNG2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_000926</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794823.1">
        <property type="nucleotide sequence ID" value="XM_056930530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XNG2"/>
    <dbReference type="GeneID" id="81620779"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16651">
        <property type="entry name" value="SPL-RING_NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026846">
        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="14">
        <location>
            <begin position="311"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="173"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="399"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="468"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5495810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="494" mass="56178" checksum="C2A036CD6FE22159" modified="2023-11-08" version="1">MLSATPARQRTSISQSRPPPSGAHAQARQNAQGRQEPELPEYQPPEFIISPEANRKLRALLDMQYLEVAKKHIHDAGMQITYSAGEVSDHLRDAQTRYQKSKEKRRNDGDGQEEDAEAGDEAYRRLAEQERKVGEIMGRLEERMRHMVDSDMKLVRMTESLKDIDKEEAQRQHAILGARQTRSQRRERRPIDSEDEDAEEDDPAREPTPVREIREANAQNPPSRRLNASLAEGQQKWEELSLTQRYANNNDYTGFYRVVHDSKYPGDEAPPLPHSSTWFAHMEDPQSAARDSPDQASSGRTRNQRQPSPVGSDDIAIDREKISMNCPLTLLRFKDPVISKCKHRFERDAIMEMITQARPMPVPGSRARQKAVKCPICGTPLTAEDLAFDRAMKRRVKRAEEEEARRAENSDSDDDDSDDRPSKREQITLASDAVDPDDDAVDIDQRPAGTQIKSEPVPSGQRESLGTSEEDGEDDEEEEEVEEEEGEEENESEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XP83</accession>
    <name>A0A9W9XP83_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_000975</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794872.1">
        <property type="nucleotide sequence ID" value="XM_056930579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XP83"/>
    <dbReference type="GeneID" id="81620828"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03763">
        <property type="entry name" value="proteasome_beta_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000005">
        <property type="entry name" value="Proteasome subunit beta type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024689">
        <property type="entry name" value="Proteasome_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12465">
        <property type="entry name" value="Pr_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <feature type="domain" description="Proteasome beta subunit C-terminal" evidence="12">
        <location>
            <begin position="222"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5495859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="277" mass="29896" checksum="5988BB3C9494CE1E" modified="2023-11-08" version="1">MTGFDFSNYNRNAALHARGVPLPKATSTGTTIVGCIYDNGVVIAADTRATSGPIVADKNCEKLHYIAPKIWCAGAGTAADTEFTTALISSNVELHSLSTGRDPRVITCMTMLKQHLFRYQGHIGAYLVVAGVDPTGVGLYTVHAHGSTDKLPYVTMGSGSLAAMSVFESMWQPDLDKEGAIALCAEAIKAGIFNDLGSGSNVDVCVIEKDKPTKLLRNYMKPNERGLKERNYRFPKGTTAWLNQKVISKEDLKKYVTIETLSGDDNLAAGEKMEVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJG0</accession>
    <name>A0A9X0BJG0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786024.1">
        <property type="nucleotide sequence ID" value="XM_056938647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJG0"/>
    <dbReference type="GeneID" id="81628897"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052961">
        <property type="entry name" value="Oxido-Kinase-like_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020:SF41">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020">
        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="166"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5469434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="427" mass="48134" checksum="55E7069D0FC309F5" modified="2023-11-08" version="1">MSPLAKDPEQVARIMLSWHALDLISCTRLQTLWAGYGSICAVQARATTDIAAKQLSELCGLEPGIAGSTYPLVLKLISPPANNNNNSDLNDEGHLRKMLSYEVEQAFYNDIVPLLGDDIPVAKCLASTRDMKGQKGAVELEGLLATLMVDLSLEFPVSGGKRGALNPRQVHAALDWLARFHRRSWTWLPDSLTRYVLPPTDEQRKRAKENGCQEKTTHRGIWLNGGYTYLATRRREYASLADDSDSEWSDLLCQPYCGSSMSAAEMTALFLTPSGRATESYIHGDVKSENLFTTVTGDRVAFYDFQYVGLGLGVCDLAKLFTCSVQMTELVDSKEQLPDRLDMGVGEKRLLEQYYRTLTQDQSSDFYEWDSFKRHWETALVDWCRFQASWGFWGNTNWLEARVRSILNDADWSNWLISTIHAKPLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJU9</accession>
    <name>A0A9X0BJU9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">argininosuccinate lyase</fullName>
            <ecNumber evidence="4">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_009215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786187.1">
        <property type="nucleotide sequence ID" value="XM_056938810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJU9"/>
    <dbReference type="GeneID" id="81629060"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000025">
        <property type="entry name" value="Argininosuccinate lyase chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="6">
        <location>
            <begin position="15"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="7">
        <location>
            <begin position="373"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5469597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="464" mass="52150" checksum="67807FB2BB04987A" modified="2023-11-08" version="1">MSNSKGVADNMLWGGRFTQGLDPLMVQYNQSLPYDRIMWKQDIAGSIAFARANMKTGILTAQEFAEIERGFKQIAEEWRTNTFEAKENDEDIHTANERRLSEIIGKEIGGKLHTGRSRNEQVATDMRLWLRDELRKLDAQLSDLVKVSIARAEKEIDIIMPGYTHLQKAQPVRWSHWMLSHATAFASELQRLREVIRRVNRSPLGCGALAGNPFQIDREAMAKELGFDDLLYNSMNTVGDRDFAMETMQWGSSFMLKISRWAEDLIIYSSLEFGFVRLSDAYSTGSSLMPQKKNADSLELLRGKSGRAFGQMAGLMMTIKGLPTTYNKDLQESIEPLLDHIKTVSDSILIATGVLSTLTAIPEKMTAALAPEMLATEIADYLVRKGVPFREGHHISGRVVQLAEQNNVPMDTLSLEQLKTVDPRFDEDVQACLDYERAVELKDAIGGTSKRAVLEQTAVLKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BN64</accession>
    <name>A0A9X0BN64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="46"/>
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            <begin position="173"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5475259.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40534" checksum="E9709F5D0B846017" modified="2023-11-08" version="1">MPSLRNVLHRRNTLTEKSLQSAAGSGKSQSGRSSPPPPPPPEITFLHTDTFGQEEIIPPSREKHASTGALTTESPLEIQFIAIAFDAVSPRSRERRLSNLLHRNSRRVSQESSTNIPEGLPQIKDDQAVDKQEREAQWEKRATVLVQNNPHFGQIHASPVYSQGDLVVPDAGSSRSRSSSQSRVGDHQDDVNIQEAIRLHEEGDLERSTAMFGQLADPNGHNNALSQVLYGLALRHGWGCTKDETRAVEYLSAAATNSAAVESEALRAGMKKGGEAKGELVLAIFELANCFRMGWGVKRDPAAARQYYETAANLGDTDAMDHAAWCYLEGFGGKKDKFKAAKYYRLAEENGNPTVGNSWIWKDKYNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
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        </recommendedName>
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        <source>
            <strain evidence="5">IBT 30728</strain>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <location>
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            <begin position="569"/>
            <end position="584"/>
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    </feature>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50882"/>
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            <dbReference type="EMBL" id="KAJ5475078.1"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="662" mass="70826" checksum="BF9001677E979DC3" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BN95</accession>
    <name>A0A9X0BN95_9EURO</name>
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        <submittedName>
            <fullName evidence="6">General alpha-glucoside permease</fullName>
        </submittedName>
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    </gene>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5475466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="550" mass="61128" checksum="0FBDBF97C0A97368" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BP71</accession>
    <name>A0A9X0BP71_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CSN12 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_007647</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788047.1">
        <property type="nucleotide sequence ID" value="XM_056937248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BP71"/>
    <dbReference type="GeneID" id="81627497"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000366">
        <property type="entry name" value="COP9 signalosome complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="246"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00073854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5477503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="453" mass="51096" checksum="3270BE166FA01CF8" modified="2023-11-08" version="1">MQLASDFRHAYSIASGPALAAVLTPIATASNPQRLRSFYEFTNAQYLTKDLQSTLFHGKSIRVSKSEQAAWVDIFAAYWEAVGEVLKYEERYPGASAVDIFIAWKKVSNALIKGYAGSNGLKAWTLPCLYTVGKFLRTFAIKADLEVAARGSTEYGFQDDLAVDVEKNANLEEAARIINRMFTLCLSDRAPIEDSRKWGIYETTNLLFKTYFKINSVGLTKNLLRAINAQSHELPSLDAFPKSHIVTFEYYLGVIHFLDEQYSKAEEHLTTAWQMCHRDAHKNRELILTYLIPCHMVTTHTLPSRQLLAPFPRLEQLFRPLSNCIRRGDLVGFDQAMAAGEAEFVKRRIYLPLERGRDIALRNLFRKVFIAGGYEEPKDGQPAIRRTRIPVFEFAAALRIGTHATSRMGVDIDEVECLLANLIYKGLMKGYIARERGMVVLSKNNTAFPGTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BPI1</accession>
    <name>A0A9X0BPI1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein mS37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mitochondrion-specific ribosomal protein mS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788015.1">
        <property type="nucleotide sequence ID" value="XM_056937216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BPI1"/>
    <dbReference type="GeneID" id="81627465"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017264">
        <property type="entry name" value="Ribosomal_mS37_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037706">
        <property type="entry name" value="MRP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="102" mass="11573" checksum="1D14CD3902A28247" modified="2023-11-08" version="1">MAPKGNVTTRLNPLRLNTINHLRVRRPNQYEQNACVTVMSSMLNCWASQGYGVEGCAALEAQLRKCMDEPKSHEKKKNTVNYHLMRMYPKVVGPRKKDGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSE0</accession>
    <name>A0A9X0BSE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788097.1">
        <property type="nucleotide sequence ID" value="XM_056936162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSE0"/>
    <dbReference type="GeneID" id="81626411"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022793">
        <property type="entry name" value="Rrn10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28054">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28054:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5480667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="248" mass="27867" checksum="3F2B5C632C3F795E" modified="2023-11-08" version="1">MAYSESGNATREHSLALPEDDTDAVESEYSYKQTRRTTNVYDAVAGENSGRVNRKGHHPDEAFASRYRDTASSGARSLRPEEVLFRTHNNPIDFDEAEYFAHERLPSQRALPRSDVLEALHAYAADFYEFATDDHGLHDHHSMDETALIALGILVEEMAKEALGETGDLVLVEGEELIDDLHGMATQRDAAPAPRSRDSSQRRKRSLNSAVDVDQVQEKPKDTGRKKKRRKIRSKSTNADADTELDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSG3</accession>
    <name>A0A9X0BSG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788530.1">
        <property type="nucleotide sequence ID" value="XM_056936595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSG3"/>
    <dbReference type="GeneID" id="81626844"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5481100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="178" mass="20676" checksum="2B5DDCF6018B5322" modified="2023-11-08" version="1">MTSDPTITLFGEKRLKNVNSLLVWSDKLSQFDPDHQEAVRFLHGLEADFDQLRQATAYEQTSPCFPLKCQIITHTIQDAIDILRRQTLFSSDEVGQVLKMIAHHIGRLSLSKQQGVDLYAEHMDRMTRKIDASWKSRKLRAPQPQAENERRQEKLQEIWDRLHFALPDCACLQCSRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSJ6</accession>
    <name>A0A9X0BSJ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_006726</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788262.1">
        <property type="nucleotide sequence ID" value="XM_056936327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSJ6"/>
    <dbReference type="GeneID" id="81626576"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="40"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="510"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="517"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5480832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="691" mass="76502" checksum="AFB0D3A9636E234A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSV1</accession>
    <name>A0A9X0BSV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_007026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788562.1">
        <property type="nucleotide sequence ID" value="XM_056936627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSV1"/>
    <dbReference type="GeneID" id="81626876"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5481132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="88" mass="9050" checksum="9DB2D2A634A1A1BD" modified="2023-11-08" version="1">MDRPSWVPTGGCLDVYERAQVPSLKPLATLVASHDSPGKVTGEEGDSANGGREVVKIGSEVFNASQVTLGLAEQVSSEPPGLESDGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BTE6</accession>
    <name>A0A9X0BTE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tryptophan synthase</fullName>
            <ecNumber evidence="3">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_006470</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788996.1">
        <property type="nucleotide sequence ID" value="XM_056936072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BTE6"/>
    <dbReference type="GeneID" id="81626321"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF2">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="194"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5483024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="510" mass="54482" checksum="83018FDD563A4FF6" modified="2023-11-08" version="1">MRRTIQKLFCFSRASKVPGTDQSPEVPPRSVTIKSIPSTPVITVPLPTSQFAAHDQTQAGCNSPPPAIPSIRARANITCASSLDSSFAESALASTTGACDNSSVTSGTNSRLEDNSSLPDGFRSVCGLQLDRRPTPPPISFNGYGSFGGRFAPESIIGFLDELTRAFESAISDPSFWKEFASFDRTQNSSLQLAVGRGAQIWLKREDLNEYGSHKTRNIIGQLLLARRMGRAEVVTDCASAKHGTFTAAMCARLNLRCVVVMGADDAQSQSEDVLEMKMLGAKILTARTPSGMGTLRAAITEALRYSVCNHETAYYLMGGPVGPNPIPTLTRTFQQRMGEEVAIQMHQETGRQPDALIAAVGSGAGAVGLFRPFLHNPAIRLIGVESAGAATLTEGSMGVLQGARTLMLQNDDGQILDCHSISPDMNLSTVGPELAYWKESGRVRIRTATDAEALDGFKTLQHHEGILSGLDSSHAVLKAIDLAKELGPGKNLVLLVTGCDSIDMRAAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BTQ1</accession>
    <name>A0A9X0BTQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Allergen Asp f 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_006078</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000007">
        <property type="protein sequence ID" value="KAJ5483878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789148.1">
        <property type="nucleotide sequence ID" value="XM_056935680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BTQ1"/>
    <dbReference type="GeneID" id="81625929"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040820600" evidence="3">
        <location>
            <begin position="22"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5483878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="286" mass="28375" checksum="6D88BA862CF1E7CD" modified="2023-11-08" version="1">MAPLSKTLALAGAFFAMTGFAAPLNKRVVVWETVTDVVWETVDVTTTIYPGQHAQTTVVPVAAAATTTSAAAAVVTSAAQAPVQSQAPAPPASKQETSAAPTTTTTTTTQQAVPTTSSVEQAPAATTAAPVVQAPAAPAAPAVESSSSSSSSAAPAATGSTGSSGQSSSKAAANSGYNGACSSGSPCIGDITYYDTATTMTNPSSCGTTNDGLTELVLALPHGIMSDSDCGKSVTVEYNGVTKTGTVVDKCMGCDNTSIDLSRAFFEAVAGSLNAGRVSGVKWYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BU73</accession>
    <name>A0A9X0BU73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_004862</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789658.1">
        <property type="nucleotide sequence ID" value="XM_056934464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BU73"/>
    <dbReference type="GeneID" id="81624713"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="39"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5484874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="437" mass="48185" checksum="5AC539497ADF665C" modified="2023-11-08" version="1">MADRSPAPTTLVDALTSALVKREAKSARRKLTVLPGTAVDFSSNDFLSLSTSPAFRNRYLSHLNSAPESFPFASGGSRLLDGNSAYAEELERFVAEFHDAPAALLFNSGYDANIGVLASIPQPGDLVLYDELVHASAREGMRLSRASARKMFSHSSPTSLKEVLSEEMKSDPWIWEGTRNVFIVIESLYSMDGDVAPIQDFIRVVDELLPRQNGYFIVDEAHATGVFGPRGAGVVQHIGVQDRMFIRVHTFGKALASHGAMVLCGPQTRDYLINYARSLIYTTALGFPFLASIRTAYELLSSGQTDSVGNPIFSPQPSLYLKLITLKQLRTRSQQLIQHLHQRLQALRVPQSVPFRVDHFATSPIFSLRTSRPRELASICQEAGYIIRAIMPPTVPRGSERVRVCLHSGNTETEIDGLVHVIQSWLDRSAISTGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUC9</accession>
    <name>A0A9X0BUC9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_005027</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789823.1">
        <property type="nucleotide sequence ID" value="XM_056934629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUC9"/>
    <dbReference type="GeneID" id="81624878"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000003">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1006"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1013"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5485039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1099" mass="123482" checksum="E0A66E4B3157882F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUF1</accession>
    <name>A0A9X0BUF1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nitronate monooxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_005102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789898.1">
        <property type="nucleotide sequence ID" value="XM_056934704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUF1"/>
    <dbReference type="GeneID" id="81624953"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5485114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="37595" checksum="451CEFA8B58904BA" modified="2023-11-08" version="1">MASPQVIRTPITDLLKINHPVLLAGMNVAAGPKLAAAVTNAGGLGVIGGVGYTPEMLREQVTELKSYLNDKNAPFGVDLLLPQVGGSARKTNYDYTKGKLNELVDIIIESNAKLFVSAVGVPPKAVVERLHAAGILCMNMIGHPKHVQKALDVGVDIICAQGGEGGGHTGDVPTTILIPTVAKLVQGRKSPLTGQPVQVVAAGGLYNGNSVAAALMLGASAVWIGTRFILSEEAGAPVAHQEAVRTAGFEDNIRTIIFTGRPMRVRKNAYISNWEENRQDEIKKLTAQGIIPVEHDFENLPDDVDDETLDNARPFLMGKVAAVVNEKKSAKAIVDELVTDAAALIKKGNQMVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUN8</accession>
    <name>A0A9X0BUN8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790153.1">
        <property type="nucleotide sequence ID" value="XM_056934959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUN8"/>
    <dbReference type="GeneID" id="81625208"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5485369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="451" mass="47855" checksum="8DDDEA4BF2EA7483" modified="2023-11-08" version="1">MLRVLSAGQWVHSPITSAVVVTSVVTETVRPTVTSTQIIIVGLTRTEASSPSSPFAPNAGPSPQPEVTGWPTQPEPDQTNAGQTQTWAPDIPNPSHLPVPTTSLTEQTHPTPTKITATLMTSLSDNPARAPSVLPLPLPSVVTSSMSTSTMSVASTASSRPGTTSLDPELRSRTLITFSRAPAAITPMSFPVTFTSLSATPSLSSAAGVTSESTFADSPHSESKPAMPSGAIVACVVGGVVCLGLVILACIFCSRRKGQGLLSSLGMASRRKSDDSLTTLHALRDSEAFPMGAVLPSQHPNMALQTTLNQLPLVDPAKHESTISVRILPSSPRGNEVGLPPCCSGAPRNQVQTCLRTPWTMSDHSDYGSDESKLDYLRPVDFGSEAHVNSLHAASNGAKKDTIKVNLTGFPELDRLAPRRDYEMRMRTRSNPFDLELPLTDVQENERPNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUS5</accession>
    <name>A0A9X0BUS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">3-hydroxyphenylacetate 6-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_005506</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Aromatic compound metabolism; phenylacetate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790302.1">
        <property type="nucleotide sequence ID" value="XM_056935108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUS5"/>
    <dbReference type="GeneID" id="81625357"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11066">
        <property type="entry name" value="CYP_PhacA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000072">
        <property type="entry name" value="3-hydroxyphenylacetate 6 hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0349">Heme</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5485518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="517" mass="57818" checksum="8A3766A258C651B9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUX7</accession>
    <name>A0A9X0BUX7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein ras-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_005375</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790171.1">
        <property type="nucleotide sequence ID" value="XM_056934977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUX7"/>
    <dbReference type="GeneID" id="81625226"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000654">
        <property type="entry name" value="Small g-protein ras2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5485387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="242" mass="26581" checksum="1F464CC85D8EBA3A" modified="2023-11-08" version="1">MSGKMTLYKLVVLGDGGVGKTALTIQLCLNHFVETYDPTIEDSYRKQVVIDQQSCMLEVLDTAGQEEYTALRDQWIRDGEGFVLVYSITSRASFSRITKFYNQIKMVKESASSGSPSGPSYLSSPITPTSGGPALPVPVMLVGNKSDKAMERAVSAQEGQALAKELGCEFVEASAKNCINVEKAFYDVVRMLRQQRQNTQNSKGRGGGAHGSSGRDRDAGPEYPKSFRPDRRHRSRLNCVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXA1</accession>
    <name>A0A9X0BXA1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790593.1">
        <property type="nucleotide sequence ID" value="XM_056933052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXA1"/>
    <dbReference type="GeneID" id="81623301"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5488560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="101" mass="11864" checksum="D274E9E79647719E" modified="2023-11-08" version="1">MRQRGEALGWDWDFGYETVATGIAIADALGTCTSSTDAHWVFLEGVPGSLLGFYYYYYYYYYYYYYYYYYYYYYYSIASPDFAVPKVPGTIENAIPPPHCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXW1</accession>
    <name>A0A9X0BXW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-activating enzyme E1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_003467</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790610.1">
        <property type="nucleotide sequence ID" value="XM_056933069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXW1"/>
    <dbReference type="GeneID" id="81623318"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000618">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000004">
        <property type="entry name" value="Ubiquitin-activating enzyme E1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028077">
        <property type="entry name" value="UAE_UbL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030661">
        <property type="entry name" value="Uba2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14732">
        <property type="entry name" value="UAE_UbL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039133">
        <property type="entry name" value="SUMO_E1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="13">
        <location>
            <begin position="12"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="14">
        <location>
            <begin position="312"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin/SUMO-activating enzyme ubiquitin-like" evidence="15">
        <location>
            <begin position="451"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="586"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="30"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="123"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5488577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="637" mass="70368" checksum="9F20BC4E7BCACCE3" modified="2023-11-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY32</accession>
    <name>A0A9X0BY32_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein phosphatase 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003994</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791137.1">
        <property type="nucleotide sequence ID" value="XM_056933596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BY32"/>
    <dbReference type="GeneID" id="81623845"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000078">
        <property type="entry name" value="Protein phosphatase 2C, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="142"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="513"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="546"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5489104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="567" mass="60822" checksum="2D2BC5FCC6271C65" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY73</accession>
    <name>A0A9X0BY73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_003978</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791121.1">
        <property type="nucleotide sequence ID" value="XM_056933580.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81623829"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="377"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="462"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="599"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="715"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="794"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="843"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1201"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="740"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="846"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="866"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="904"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="918"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="969"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="994"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1009"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1204"/>
            <end position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5489088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1332" mass="147408" checksum="78E9656545B7348F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYA4</accession>
    <name>A0A9X0BYA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_004219</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791362.1">
        <property type="nucleotide sequence ID" value="XM_056933821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYA4"/>
    <dbReference type="GeneID" id="81624070"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15488">
        <property type="entry name" value="Tm-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12030">
        <property type="entry name" value="Uncharacterised protein family UPF0261, NC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12020">
        <property type="entry name" value="Uncharacterised protein family UPF0261, NN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051353">
        <property type="entry name" value="Tobamovirus_resist_UPF0261"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056778">
        <property type="entry name" value="UPF0261_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044122">
        <property type="entry name" value="UPF0261_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862:SF1">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06792">
        <property type="entry name" value="UPF0261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23189">
        <property type="entry name" value="UPF0261_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0261" evidence="2">
        <location>
            <begin position="7"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="UPF0261" evidence="3">
        <location>
            <begin position="265"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5489329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="509" mass="54513" checksum="38E130C7DBEA8580" modified="2023-11-08" version="1">MPPPTTPTVLLLGTCDTKLPELLYTKSQIETRSPCTVQIMDIGRNPIIPIDPNITFTPDIYSSHFTSRKRPTVEINSLNRSEYIDTLAFYASAFVADLFAEHKVHAVIGIGGSCGTALATQVMRDALPVGVPKLMVSTMASGDVGPYVGETDVTMMYSVVDIAGRNRLLERVLSNAAGAIAGMAKVYFEDVVVPETKATTAAQAQSQGRTVPDATKDSSTSSESTHQAEPQPQPQPQRHQPQPSTQTQETITDNNKNNNTSNPIRIGITMFGVTTPAATTARKRLESNLPSCEIYVFHATGSGGKAMERLIRESQLDAVLDLTTTEIADEVVGGVLSAGPSRLCAATKRNIPRVLSVGACDMVNFGTPDSIPPIFTAAGADAEGSGGAQQKRVFHRHNATVTLMRTTGEECARIAKVIATNLLEGNAGWEQDCRTKVILPLGGLSFLDTPGQPFWDPDADNALFATLEDELRASEIAIIRDERAINDPGFATAAADLLCELISQDQNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYE9</accession>
    <name>A0A9X0BYE9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791165.1">
        <property type="nucleotide sequence ID" value="XM_056933624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYE9"/>
    <dbReference type="GeneID" id="81623873"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="241" mass="26287" checksum="8C83DDFF73AB11ED" modified="2023-11-08" version="1">MDSYQSAHASGPTGNGHPSRSEFLARIASASRQDHQPSTPRIPRMARINWRAHRAHLARETRETRVVHSSTTSLGPCSSSRTQLHQRRALLAHLSRLRRRGILCCRCSRTTRRLFRREIMSSSTRAPASTSDSESSLTSVPDSVLSSGPNSVSGTPSASISASGSDAPVSQIVSPEIAPRETSEDSMSISSGKLIVLLTHISILPSFPQLTGRIQQSNHPKLAAETAQVRDKNQRSRLPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYW8</accession>
    <name>A0A9X0BYW8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycine zipper 2TM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792225.1">
        <property type="nucleotide sequence ID" value="XM_056932266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYW8"/>
    <dbReference type="GeneID" id="81622515"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008816">
        <property type="entry name" value="Gly_zipper_2TM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014:SF9">
        <property type="entry name" value="CONSERVED HISTIDINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G11910)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05433">
        <property type="entry name" value="Rick_17kDa_Anti"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycine zipper 2TM" evidence="2">
        <location>
            <begin position="171"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5491096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="281" mass="30802" checksum="A96895465AB4F2DD" modified="2023-11-08" version="1">MGDPYNPYTAFATPAPGGVGYYSAEQQHQQQYQYSTQGPPTDYQLSQPGPGPESSCSYTPQPGLNPNAHHLTSEPYPAATPNRSHTPAGQPDYLGPVHALGPRPASGDGTKVPENLSYYYPSEETPRYDPPASPRPPSVHVSNADDRHQDREHNREGDGQTGDFEGERGIGGSLVGGAAGYYLGSKKNHGLLGAIGGAVVGNMLGNKLRDHSDDGQSSGHRHRHGHGHHRHDHDHGHESSHHYGPHHHHHREHDYEHGRHHHHHHRHSGSRSRSRHADEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ87</accession>
    <name>A0A9X0BZ87_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase, mitochondrial</fullName>
            <ecNumber evidence="6">2.7.7.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">CDP-diacylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">N7539_002499</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792061.1">
        <property type="nucleotide sequence ID" value="XM_056932102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ87"/>
    <dbReference type="GeneID" id="81622351"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015222">
        <property type="entry name" value="Tam41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619:SF0">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09139">
        <property type="entry name" value="Tam41_Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="477"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="496"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ5490932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="511" mass="57329" checksum="1F9592B79E04DC3A" modified="2023-11-08" version="1">MLRAHSVIPRAIWRSAARIEPFSSQVSSARCISNHSRPTSDAPFYQSTLSGCSTSHLLHNDCGGSARPAAPFSTSSTLREADWDQNPNLAISNFSELPSKDFGVNQHMIINQEFKEALRQILWQFRAPIRYAFAYGSGVFPQSGSGTAGSTHPAAPAAIQKMQKGSGKMIDFIFGVSYSQHWHDLNLNQHRDHYSGLGSMGSYVVSQVQDKFGAGVYFNTHITVNGTLIKYGVVNLDTLCTDLTQWNTLYLAGRLHKPVKILRDHPKVRLANQMNLLSALRVALLLLPERFSEFELYNTIAGISYMGDLRMVLPTEDPSKVRNIVSGQMAHFRRLYAPLIANLPNVSFSDPRCGQNDWIDDPDSVLAMVQDMDPVKRGNMVRRLPEAFRQKLYFQYQARFAIPRVEFNKMMEENDDAKQGIVRRPQGGPFERRIAENDHLKTEVSSSISKTIRWPSTVQSIKGTFTAGIGKSLVYVKEKRDKHRKAQAQQAQSSEKAPKSESPAKSEKKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZD9</accession>
    <name>A0A9X0BZD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792823.1">
        <property type="nucleotide sequence ID" value="XM_056932864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZD9"/>
    <dbReference type="GeneID" id="81623113"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025444">
        <property type="entry name" value="Monooxy_af470"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13826">
        <property type="entry name" value="Monooxy_af470-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="319" mass="35686" checksum="AE8C6FA47668A168" modified="2023-11-08" version="1">MTSSFNPLLPPHIVPPSEPDQRGTPIPFPRKNGSFTPVIRDAMSLTSWLLLGAVIQGLACLLFGSRATIPALLILIYRVTDHLLMTLNITRNRYLDHVLFAKASPQIPPPNGTFGTEPSRDKIVVFHLGVRSHHPLGFLAPGMKGIADEFTAMVSEMQADPEKVGLLGMSQFLKQESVAGNEILTIFYLRDYESLHRFAYGKSHMKGVRYFADITKKCPHIGIFHETFVVPKGHWEAIYINIEPTGLGDTWFLVNQTEQSDHETTAKERVKKEEKGSGAQAFIRPLVDARSGVLRSKTGRLSMKKMEEARQYDQVFGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZP5</accession>
    <name>A0A9X0BZP5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mutanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793152.1">
        <property type="nucleotide sequence ID" value="XM_056931121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZP5"/>
    <dbReference type="GeneID" id="81621370"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040799143" evidence="2">
        <location>
            <begin position="21"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5492772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="518" mass="56032" checksum="28CF4C818987BBF7" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZQ0</accession>
    <name>A0A9X0BZQ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein MSH3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 14">DNA mismatch repair protein MSH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">MutS protein homolog 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_002979</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792541.1">
        <property type="nucleotide sequence ID" value="XM_056932582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZQ0"/>
    <dbReference type="GeneID" id="81622831"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000008">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000006">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000004">
        <property type="entry name" value="DNA mismatch repair protein Msh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001909">
        <property type="entry name" value="DNA mismatch repair protein msh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF122">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="16">
        <location>
            <begin position="979"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5491412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1139" mass="125365" checksum="8FCBDC0D17188C45" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0H5</accession>
    <name>A0A9X0C0H5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short chain dehydrogenase atnD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="81622076"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF67">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="320" mass="35355" checksum="49A5BE3AE6555D1F" modified="2023-11-08" version="1">MAFLYSQLFVRPPYPTQSFEGQTVLVTGSNVGLGFEAARHIARLGAARVILGVRNVSAGEKAKEQIEASTGRSGVCEVWEVDLASNKSTIAFGDRINQLPRLDAAILNAAVATEQFDLVEDYERTITINVINTLLMGLMILPRLKATGKEFPTTQPRLEFVVSEVHAWVNFTEWKESDTPMKVVSDPTKAKMTERYMLSKLLEVLLVQEVASRTRASDVVITMVNPGLCHSALNRERNWQLAMLKTVLARTTEIGSRTLVAGISTGVEGHGSYMCDSQVCNTALSPFVRSDEGRAARLTLWKELTMILEQVRPGILDNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0H9</accession>
    <name>A0A9X0C0H9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_002239</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793873.1">
        <property type="nucleotide sequence ID" value="XM_056931842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0H9"/>
    <dbReference type="GeneID" id="81622091"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040850374" description="Integral membrane protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5493493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="28706" checksum="9616603706822EED" modified="2023-11-08" version="1">MFLTITRAHGLGLLLVALYASATAAANILPAAASASFPECGLSCTPLTQAQASCESGAQATWVSCFCQSALLPTLKTSGSLCTSCTAPADQALLSTWYNAYCNSNGQNTGNTSPSTDTASTTAAVASPTASSSNSISNHASTSEVQPSWWSTHYKWVIMLIVLAIGFGAIAAVGAYLKRRHDAKRANLYHTGGPMDSSSGVLEGNPYSPSNSETVTTVKPAWAAPAGHDTSQSLASSSRTEITTTRGGSTLPPGSRTRLPKPSQPNGNIEIHQRPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0V1</accession>
    <name>A0A9X0C0V1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_002256</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793890.1">
        <property type="nucleotide sequence ID" value="XM_056931859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0V1"/>
    <dbReference type="GeneID" id="81622108"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000247">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF60">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17160)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="70"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5493510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="557" mass="62957" checksum="7D2504F3AB884023" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0X7</accession>
    <name>A0A9X0C0X7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">quinol--cytochrome-c reductase</fullName>
            <ecNumber evidence="3">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">N7539_002180</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="17">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793814.1">
        <property type="nucleotide sequence ID" value="XM_056931783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0X7"/>
    <dbReference type="GeneID" id="81622032"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 17 18" id="KW-0349">Heme</keyword>
    <keyword evidence="13 17 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="19">
        <location>
            <begin position="96"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ5493434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="318" mass="34890" checksum="57E95B181FEA856B" modified="2023-11-08" version="1">MLGRSLPRVAARAFARQPVGKSTRASSTAAGADAASSPFYLTLTASLATAAAAGSAAWYYHLYGQEAFAMTPAEEGLHATHYPWVHQRFNKTFDHAALRRGFQVYREVCASCHSLTRVPWRSFVGVMHTVDEMKAMAEENEYDTEPNDQGEIEKRPGKLSDYIPAPYKNDEAARAANGGALPPDLSLIIKGRHGGCDYVFNLLTGYPDDPPAGASVAEGMNFNPYFPGTGIAMGRVLYDGVVEYEDGTPATTSQMAKDVVEFLNWAAEPEMDERKKMGVKAITLLTGLFAISIWVKRYKWAPIKSRKIVYSPPIAPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2D5</accession>
    <name>A0A9X0C2D5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793962.1">
        <property type="nucleotide sequence ID" value="XM_056929669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2D5"/>
    <dbReference type="GeneID" id="81619918"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF11">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5494949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="61047" checksum="FA3CA000A4C39B61" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2L1</accession>
    <name>A0A9X0C2L1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DHHA2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794278.1">
        <property type="nucleotide sequence ID" value="XM_056929985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2L1"/>
    <dbReference type="GeneID" id="81620234"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA2" evidence="1">
        <location>
            <begin position="293"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="473" mass="52065" checksum="F6DB81647D636891" modified="2023-11-08" version="1">MTLLQFLRQARQLHLQFLAGALSEPPVYVLGNTSADLDSIISAIVFSYCAHNRLPSNAPRSYIPLVNLANVPSGPELYRLRPEFVTALWLSTNFPPLPSEEPFDNTSQSASKFLSEHLVTVADFAQTVTGQHSSSPSETQIQADTVMVDWNAMPQRLDSGPGYGSISGLDGVTFGTVGCIDHHVDEGFVPQLEINSAEYPCVIEPGPGSCSSLVTRELRTRGLWSGSNSHQVSEAEWAQVAKLTLAPILIDTSNLTAEGKVKEVDIQSVDFLRDMVSRANGGVGAEWDMVAFYEKIHKAKAESLNLLTPAEILDRDYKEWVEKTHRSGTTIKLGFCCSVRPLRWIIQKAGGPQQFMEVVRQFAQDREKELDLVVVMTSFSSSKGEHTRELFVSASQEKGLPIDGAQNFAEESTSLGLTEWTSLDGESVDVADDEIRKVLNGTSGGWRQLWLQKNATASRKRVAPLLREALTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2M5</accession>
    <name>A0A9X0C2M5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_000742</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794639.1">
        <property type="nucleotide sequence ID" value="XM_056930346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2M5"/>
    <dbReference type="GeneID" id="81620595"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="34"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5495626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="447" mass="49741" checksum="9D8E974ABFF5DB37" modified="2023-11-08" version="1">MDSTKPLDEQIPSPGQWPVDPQEDMPVSEDRIWVDGCFDFSHHGHAGAMLQARRLGKALVVGIHSDEAILENKGPTVMSLDERVAAVDACRWATLSVPHAPYVTYLPWVSHYGCKYVVHGDDITSDSDGNDCYRFVKAAGRFKVVKRTPGISTTDLVGRMLLCTKNHFVKSVKKTLTGEEGSGNPDERKAFANDLLQRIRDYATDETGLQPGPQVWTWEGSGQAKIENEVAESGIFAPLVEGKGPKPGQRIVYVDGGFDLFSSGHIEFLRKVMETEEAEGRRRGWFESAQREKRVQETGEDYSPAYIVAGIHDDGVINHWKGLNYPIMNIFERGLCVLQCRYINAVIFSAPFTPSQPYLEAMPLGTPDIVYHGPTTFIPLTYDPYVDPKKMGIFQEVGDHAFQHVNAGEIVGRILKSREAYEARQRAKLEKAIAEDLVKAQEQAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WK91</accession>
    <name>A0A9W9WK91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Purine-cytosine permease fcyB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_009506</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785596.1">
        <property type="nucleotide sequence ID" value="XM_056939101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WK91"/>
    <dbReference type="GeneID" id="81629351"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11484">
        <property type="entry name" value="SLC-NCS1sbd_CobB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="484"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5466550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="510" mass="55529" checksum="F72115821C2D6D9E" modified="2023-11-08" version="1">MNPDMEKLPGGVEPFLVKNDAGPQPASGAGARWSARIQRLSSLIKVEQRGIERVPENERTDSSYWNISSMWLAANMVVPSFTVGVLGAPLFELGFVDSALVIIFFNLLGILTVCFFSIFGATFGLRQMVLSRFWFGWWGVKLIAIFNVLSCIGWAAANIIVGAQLINAVNPNVPGYAGILIIAICTLLIVFFGYRVIHAYEYWSWIPTFIVFLVVLGVLAHSGDFINSPMGAGKAELGAVLSYGSTVFGFGTGYTSFAADYTVYQPSNRPRRNIFLATFLGIFPTLLFTELLGAALATTMAQNGGHNAYQQGYDDAGIGGLLGALLFPSLGGFGKFCVVILALSIVANNCPNVYSVSLTLMVMGRWTRHVPRFVWTVVATGVYIAIAIPGYNSFESVLENFMHFIGYWLAIYEGVGITEHFLFRRGFSGYRPEYYDMQEKLPLGIAALLAFCCGIAGMVIGMSQTWYVGPLAKFAGTAPSGGDIGFELGFAFAAVSYAVLRPIELHIVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKJ5</accession>
    <name>A0A9W9WKJ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_009441</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785758.1">
        <property type="nucleotide sequence ID" value="XM_056939036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKJ5"/>
    <dbReference type="GeneID" id="81629286"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000013">
        <property type="entry name" value="TRAPP complex subunit, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5466712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="196" mass="21997" checksum="718BF669F25CF607" modified="2023-11-08" version="1">MTVYSFYIFDRHAECIYKRRWLPRPASIAGKSGQSATPAISAGGGQTVRATDDDSKLVFGTVFSLRNMVRKLGGDDDNFVAFNTSQYKLHYYETPTNIKFVMLTDTKSPSMRIALQQIYINLYVEYVVKNPLSPVEHPGGVGVNNELFEESLEQFVVSVFETFAPPHFVLYYSNHGSDLGQLDARAFLTAILTTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKN3</accession>
    <name>A0A9W9WKN3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_008877</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785849.1">
        <property type="nucleotide sequence ID" value="XM_056938472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKN3"/>
    <dbReference type="GeneID" id="81628722"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="84"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5469259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="537" mass="61350" checksum="BAAD6FD7020511A9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKV7</accession>
    <name>A0A9W9WKV7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Tryptophan synthase</fullName>
            <ecNumber evidence="3 10">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_008963</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="3 10"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785935.1">
        <property type="nucleotide sequence ID" value="XM_056938558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKV7"/>
    <dbReference type="GeneID" id="81628808"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="63"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5469345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="430" mass="46306" checksum="1436CAC33C30BDEF" modified="2023-11-08" version="1">MFTAEKHYLQRYPDSNGYFGQFGGNHYPAELRPALEELAGSYEKLHSTQEFQHVLTRARIGLQGRPTPIHCLENISKEIGGAQIFVKREDLNHTGAHKINHCVGFALLAKKMGKKRLIAETGAGQHGVALATAAAFFNLECEIHMGEVDIAKQSSNVGRMRLLGARVVAANQGQSALKEASDSAFHAYVQQHEIALYAIGSAIGPHPFPMIVRDFQSVVGQEARKQFLDMAQDEDRLPEHVVACVAGGSNAMGMFSGFVDDAEVTLHAVEPCGVSERLGEHAATLSYGRPGTLHGARSVVLQREDDTPAQVSSIASGLAYPGVGPEMAMLHETGRISVAAVSNEEAVEAFYRTTRSEGIIPALESAHALAFAFQLAARRPSSERILVNLSGRGDKDVDFILENYGVKAPATDASAVGKSLNEETTNHLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL07</accession>
    <name>A0A9W9WL07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_009057</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786029.1">
        <property type="nucleotide sequence ID" value="XM_056938652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL07"/>
    <dbReference type="GeneID" id="81628902"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="32"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5469439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="141" mass="15070" checksum="102501C048C6F03D" modified="2023-11-08" version="1">MAPPKAAEKKPSTAGKAPVGGKAPAEKKEAGKKTSAATGDKKKRGKTRKETYSSYIYKVLKQVHPDTGISTRAMSILNSFVNDIFERVATEASKLAAYNKKSTISSREIQTSVRLILPGELAKHAVSEGTKAVTKYSSSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLA6</accession>
    <name>A0A9W9WLA6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_009192</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786164.1">
        <property type="nucleotide sequence ID" value="XM_056938787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLA6"/>
    <dbReference type="GeneID" id="81629037"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041000755" description="Mannan endo-1,6-alpha-mannosidase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="402"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5469574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="463" mass="49291" checksum="A6EAFBF257138F36" modified="2023-11-08" version="1">MRGVQWESSLAVALLCGSASAVAFNAKDEASVKNAASVAANNTIALYNGRNTSDIPGKWAGAWYPGGVMFDTLINYWYFTGDSTYNKVVSDGMYWQAGNDSDFFPSNYSQSLGNSDQLVWGFAAMSAAEMNFTRNSSRPSWTTMAENVFNTQVARWDTHNCKGGMRTGIWPYQEDYQLKDALSNGGLFELAARLAHSTSNKTYSEWAEKIWTWSGTTSLLDVDAGSVSDSTTCDSNCSKRSTSLEWSWNYGVFLSGAAYMYNMTNGDKKWKTGIDNLLNATTLLFFPTDGFGLADGKIMIEMACEPSNTCDQSQVVLRSTFIQSLVQTALKAPYTLSKIVPLLQGSASAAAITCTGGKSNLCDGPWYMEKNGVNGTTEDQMAALSIFTSNLIAFQGSGSAASSPGANSTNSSSTTASPTQTASSTGASGAATTTAGNNEAGVLVSSTRAMLLAIFLAAFAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WMA4</accession>
    <name>A0A9W9WMA4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_009346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786318.1">
        <property type="nucleotide sequence ID" value="XM_056938941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WMA4"/>
    <dbReference type="GeneID" id="81629191"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040783520" description="WSC domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5469728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="194" mass="19610" checksum="C1DD0C814DEA8034" modified="2023-11-08" version="1">MQISQVLTTLALAMPALVSASALYPSMGCYSEVPDLKNDTTNVFNSYGLCADQCRQGHYKFAVLSKGDHCGCSNAVPPPANKVADDQCKTACPGYPEDICGGNTTYSVLNVHDQSNFVSSMTVKASATTTAGGIVVAASTPASTATATNAETTAMSSASASASASATPSFNAASSMREGSSLAGVLFAGLALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQJ9</accession>
    <name>A0A9W9WQJ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786345.1">
        <property type="nucleotide sequence ID" value="XM_056938337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQJ9"/>
    <dbReference type="GeneID" id="81628587"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="89" mass="10096" checksum="C865A60A861D0B8C" modified="2023-11-08" version="1">MFQSQASSQFSEHYPSSAFEDNPRDTLSFFTSDGLFNVDGRETPISTPDVSLLRPVIPPAFPGTLERVNPPKRKDYILWTEMANKDFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQP7</accession>
    <name>A0A9W9WQP7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786473.1">
        <property type="nucleotide sequence ID" value="XM_056938091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQP7"/>
    <dbReference type="GeneID" id="81628341"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="378" mass="42544" checksum="67556DC9DCA14939" modified="2023-11-08" version="1">MADNNSPGYNTLFLNQIEERTRRTNVNLPQPSLPTTESRNAVPLNHRDDTPSQGKPSTIGSEQGLETYERIAVEDHVRDIISELCKIPAAREEFMLGDALILLTVEYKPPHKLSVETLWAGLRPMELWEEIFKCNTVPTDPVEKLRYNAERLVDSAIVQAYDVMIEEGRADAILTNGLARVLHVPYNDPATLLYHFCEPHTEINGEDLLNLRQPKTSVARVLCHCLRSFHSPIRDQEWRNSARSQLHVWESSFDHARSLIPEEELRKTPPHSENTSSPELTSSDYQPSSSPLKSPTEYALNIVRSHRSRPAPTQTKRQGANAASAKSPLLRLPNEQLVNARLAILKTTSLASVMRNFAPSDVYLDCSPAMLLTITAQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQS8</accession>
    <name>A0A9W9WQS8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786352.1">
        <property type="nucleotide sequence ID" value="XM_056938344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQS8"/>
    <dbReference type="GeneID" id="81628594"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="85" mass="9230" checksum="9985087F5FE2210B" modified="2023-11-08" version="1">MESDSPGYRGAGTNASFHNTIEGPIEPTYGPSGYLSTEIIPATRETSVTYIASEYQEFPEVFAHLPLTGNPPASFQEIYDVDDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQZ1</accession>
    <name>A0A9W9WQZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008612</name>
        <name evidence="3" type="ORF">N7539_008634</name>
        <name evidence="4" type="ORF">N7539_008698</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786589.1">
        <property type="nucleotide sequence ID" value="XM_056938207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQZ1"/>
    <dbReference type="GeneID" id="81628457"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5472043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5472065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5472129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18472" checksum="2AF49650FD3920D1" modified="2023-11-08" version="1">MMVASHDTNNEARDNIKHMKREAQRKHRKTQKERRQYDMKKVEELERRLQESDQKIQELNIQLVQSRAEHSQCAPRADQAQEALRENQRILKLMMTKLSPSSSHPANNIDTKFGGSGSWLTFTPRLNGHSQSWPCLSPVSPMPGNESSGISPGAIELTGKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WR39</accession>
    <name>A0A9W9WR39_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786630.1">
        <property type="nucleotide sequence ID" value="XM_056938248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WR39"/>
    <dbReference type="GeneID" id="81628498"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="140"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5472084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="211" mass="24332" checksum="FFDB033C6D1E41FF" modified="2023-11-08" version="1">MPLAIDALTLPEKAGETLVNRLREATDWAQAAIASAQDYQEEQANRRRQAAPVYKKDDWVWLNLRNVRTQRPSKKLDWLHARYRVLDVLSPFTVRLDVPTGIHPVFHIELVRPAATDPFPSQIIDDTQPLPPLIDGEEEYEVERILAVRRRKIGREYRDEALVKWTGWVEPTWQRLDLVQNCAALDAFEEQHGPVSDVIHHQIDAGNHEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTE9</accession>
    <name>A0A9W9WTE9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786901.1">
        <property type="nucleotide sequence ID" value="XM_056937809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTE9"/>
    <dbReference type="GeneID" id="81628059"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5475143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="78" mass="8607" checksum="D2DE3F7B90894791" modified="2023-11-08" version="1">MRYHKPAAIPVCVQSAITAFLLIGSRSLHGIKTIWINISEAITIDSTEGLQYGSIAERSDYEGMVGGILYIPRQQSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTM4</accession>
    <name>A0A9W9WTM4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein bS18m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_008079</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786771.1">
        <property type="nucleotide sequence ID" value="XM_056937679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTM4"/>
    <dbReference type="GeneID" id="81627929"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.640.10:FF:000013">
        <property type="entry name" value="37S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF40">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5475013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="192" mass="21733" checksum="93AF43177AB206E3" modified="2023-11-08" version="1">MSQSLFSSPLLRNVANVLPSACRWSSSSTAAMSAFASQRASPSHNQTPRASIRRRLPNRLRFLEEQKAQGESRALEKFQTRDWKAGDVYAPHDLSPAEMKKWGKRKSPSRDAFDALNLNPLELYRNFSIMSEYVSPLGRIKSRDQTGLRPVNQRKIAKAIRRAMGLGLMPSVHRHPEVLAADMKARLDNSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTQ8</accession>
    <name>A0A9W9WTQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056937724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTQ8"/>
    <dbReference type="GeneID" id="81627974"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5475058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="87" mass="10619" checksum="94A0DACCB5C62B81" modified="2023-11-08" version="1" fragment="single">PDRRKAFILYDRIRKASTYLRYKNSIEFNFPYTSSDKISTYYLYVLLYREAKLLKKFFSYKEIEATKKEKDKKLNEVKIDLISNTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUE0</accession>
    <name>A0A9W9WUE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_007940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787406.1">
        <property type="nucleotide sequence ID" value="XM_056937541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUE0"/>
    <dbReference type="GeneID" id="81627790"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5475653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="79" mass="8692" checksum="C9BF2FB790FEC5FE" modified="2023-11-08" version="1">MSVPGRVAPFPCVHAPLVLSIDFYPPPAQLFERYHDPSYGEVAKNGTLHPRPIGRWGNGGFMAINRQQSLTLLPSPPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUF3</accession>
    <name>A0A9W9WUF3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_007084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5476940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787484.1">
        <property type="nucleotide sequence ID" value="XM_056936685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUF3"/>
    <dbReference type="GeneID" id="81626934"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5476940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="312" mass="35280" checksum="48BE6A31FB7F1AB8" modified="2023-11-08" version="1">MRMKSIGQQLVTQWYDVQQLAYLHNLVIKSPTYQNLRWPNIDAFLKIHGESHIFIGSRPKNARESLNRLELATGISSATNFARDSRSQRSHKPNSKNTRVLKSTTTVADLFFASYIGGPEEDRGIANIHRILDELSRHSNIQSPSKALKKSNPELIITRKWSNTHNINPLMYIRSIELLRLIRDKENDKFVQYFTPEYMPDESLISNIVILIHHVAEGSAQQARELGLVSDEAGAVSRIVVSAGDVMREYLEKNGDVACKELRTFCKNKKPIQDDVAHDNDKSNELVYSWLSLEDVLGAKGVVSLMTGIPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUI0</accession>
    <name>A0A9W9WUI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HOOK N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_007117</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5476973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787517.1">
        <property type="nucleotide sequence ID" value="XM_056936718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUI0"/>
    <dbReference type="GeneID" id="81626967"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22211">
        <property type="entry name" value="HkD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
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                <person name="Frisvad J.C."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5480941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1234" mass="137828" checksum="005219CB0772CE0D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X230</accession>
    <name>A0A9W9X230_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788459.1">
        <property type="nucleotide sequence ID" value="XM_056936524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X230"/>
    <dbReference type="GeneID" id="81626773"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5481029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="630" mass="68868" checksum="2F4FCB1AE998B09A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X242</accession>
    <name>A0A9W9X242_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="6">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_006895</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788431.1">
        <property type="nucleotide sequence ID" value="XM_056936496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X242"/>
    <dbReference type="GeneID" id="81626745"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF116">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE (CYTOCHROME) (AFU_ORTHOLOGUE AFUA_7G02560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="9">
        <location>
            <begin position="179"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5481001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="612" mass="67106" checksum="71573A806E21EDC7" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X326</accession>
    <name>A0A9W9X326_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788813.1">
        <property type="nucleotide sequence ID" value="XM_056935889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X326"/>
    <dbReference type="GeneID" id="81626138"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF2">
        <property type="entry name" value="DUF3602 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5482841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="165" mass="17420" checksum="244E2E3FBB045571" modified="2023-11-08" version="1">MPSARTASYRVIEPHPSVPSSNRPALYTGRGGSGNVISLKNTKTTDSRTATGPASLARLDSRGPSTYTTGRGGAGNVHSSSERAIFSFDEELERDLRRAAPVYHVGRGGAGNMIYSDDASNCSLSRKYSSTSTNTTSSTGSVADRARDMARRGLEKGWGKLKGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X490</accession>
    <name>A0A9W9X490_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tetrapyrrole biosynthesis uroporphyrinogen III synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788916.1">
        <property type="nucleotide sequence ID" value="XM_056935992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X490"/>
    <dbReference type="GeneID" id="81626241"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10090:FF:000011">
        <property type="entry name" value="Uroporphyrinogen-III synthase (UroS), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="76"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5482944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="359" mass="39324" checksum="2FF1527564EF42A2" modified="2023-11-08" version="1">MSGPTPILLLKTRSSPHDGYHEYFSEEFQPRFVPVLEHRVHGKNLERVRGLFASGAFAGEDQGPGSSGELGATGRRFGGMIFTSQRAVEAFALMIEENGLPFTPSQTKPFPLYTVGPATARALAALRDKYLPGATIYGEDAGNGQNLAYLILEHYNTIYPDSTAEPQHGSSPPTKPSLLFLVGEQRRDIIPKTLMGPDRPETDRIHVEEIVVYETGEMESFEADFADAVRQCRVKTQHTGPTDSPSLSGPTAPIWVVVFSPTGCEAMLRVLKMGPFGKNASDGNENPHESGKQAARPDIFVATIGPTTRDFLREKFAFEAHVCAEKPSPEGVAEGIRWFMAMRETDAQSKMETTDHIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X4W4</accession>
    <name>A0A9W9X4W4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_005783</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789257.1">
        <property type="nucleotide sequence ID" value="XM_056935385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X4W4"/>
    <dbReference type="GeneID" id="81625634"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF228">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="28"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5483987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="363" mass="39984" checksum="2233C5DFE1C2349B" modified="2023-11-08" version="1">MFSGMFRRRQASDPAAAESPSPYQVPLYINAAYYPNWRIYKKQPPSSLRLGFISHVFYAFAWVREDGTIYLSDQWADTQMPVDGTEGCLRAFVQLKQQYSKMRVILSVGGGGKGSENFAAVARNRSLLDTFAQSARGLVDQFGLDGIDVDWEHPADPQQGRDYVRLLAKLREVLPAPRFVLASCLPAGQWALQNIDLTSAHQYLDMLNLMAYDFSGPWNPETAHQAQLYGSPISGCTAVNYVLSQGVPSRKIILGIPAYGRSFLGSNGPGQFYSASGGEEGVFDYSDLPRPGSVEYYDKSIGAASCVGPDGGFVTYDIPATVQQKAEFVTSSKLGGLFYWHICSDVRGPRSLIETGYNTLHEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X4W9</accession>
    <name>A0A9W9X4W9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_005713</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789187.1">
        <property type="nucleotide sequence ID" value="XM_056935315.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81625564"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048189">
        <property type="term" value="C:Lid2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036205">
        <property type="term" value="P:histone catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04710">
        <property type="entry name" value="BAH_fungalPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000018">
        <property type="entry name" value="Lid2 complex component snt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029617">
        <property type="entry name" value="Snt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR33788:SF1">
        <property type="entry name" value="ZINC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="At2g23090-like zinc-binding" evidence="3">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5484901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="74" mass="7971" checksum="CA4AAF2CC0D21A51" modified="2023-11-08" version="1">MGNGAKANMKRERNAADKGKVAKSQIKTNEKAMNIQCKVCLQTFLQTTKAPALLEHASNKHKKGLADCFPGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6A0</accession>
    <name>A0A9W9X6A0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789700.1">
        <property type="nucleotide sequence ID" value="XM_056934506.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81624755"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014839">
        <property type="entry name" value="Crt10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08728">
        <property type="entry name" value="CRT10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5484916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="785" mass="88317" checksum="292B46030631686A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6L4</accession>
    <name>A0A9W9X6L4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional activator of proteases prtT</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Zn(2)-C6 zinc finger-containing protein prtT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_005303</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the prtT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790099.1">
        <property type="nucleotide sequence ID" value="XM_056934905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6L4"/>
    <dbReference type="GeneID" id="81625154"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000011">
        <property type="entry name" value="Transcriptional activator of proteases prtT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR OF PROTEASES PRTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="12">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5485315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="612" mass="68014" checksum="F390489BCBA28B73" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6Q3</accession>
    <name>A0A9W9X6Q3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790076.1">
        <property type="nucleotide sequence ID" value="XM_056934882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6Q3"/>
    <dbReference type="GeneID" id="81625131"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5485292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="478" mass="52109" checksum="939C4DA5E52277EF" modified="2023-11-08" version="1">MATTVLKVGILGLTPATEPIYVGILSSLSQHYALTIVHADTKELALSIQQGSSSPRVTAIPEEVIQNSEVNLIINLFPFRQHEPYTIAALQAGKHVMVKTPLSLSPSTLSQIRAALGDDHKSSDTSSHSALSSDCSRPQFFISCARRYAPCFTEVFKRELASLEIIHYVRCRNITGFASTPDVSNINPRSLGATTTTKPEASDEGTINHATDTIDINIPSRPKPSSSSSSSIPLSHRHLPKHMHAVLADIFGPKVEATADREALCHFIGTSGSHDFSLIQESFGFPDAVSHVSIIKPFYNAMFHYKDGSVSSSRGASQPFTLFYEAGVDGVPRSDAHLTVYGLNKTISFSYQLSHPSEMNRSSIVARVVVETVDHGTDADGDTDVNMGNGISDANGNRPVPEQLRLKRTEYVNTANEVYEQEFLAMHAQLTGAATSDLKDLKVRPKTSLNDATDDLKIMHMIFDHYDRQCGTIRTPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6R3</accession>
    <name>A0A9W9X6R3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIP41-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790147.1">
        <property type="nucleotide sequence ID" value="XM_056934953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6R3"/>
    <dbReference type="GeneID" id="81625202"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5485363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="275" mass="31373" checksum="A08B82BAEB02F205" modified="2023-11-08" version="1">MASRYPVGPVGHATVSPEAKKPQSIAVGGFRISTQKLPILKAEPIEEMTKQLGIAPPEMIFGDNHVTIEHQKSGWGIDFNAFDALDRVDKTGQSMLQVAHSKEWQQSREKTHEGIKEVVKPFDWSYSTDYKGTLSPNAPSFESTEKPIPIELLKRPDPIVFFDEVVLYEDELADNGIAMLSCKIRVMPARLLLLSRFFMRLDNVLIRLRDTRVYVDFETREVIREYQAKECEYEKVRQILASTRDDIPALMRDPNRLSEILPVVEKSSERIILDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X786</accession>
    <name>A0A9W9X786_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar segregation subunit 7-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790195.1">
        <property type="nucleotide sequence ID" value="XM_056935001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X786"/>
    <dbReference type="GeneID" id="81625250"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010513">
        <property type="term" value="P:positive regulation of phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903778">
        <property type="term" value="P:protein localization to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024260">
        <property type="entry name" value="Vac7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258:SF1">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12751">
        <property type="entry name" value="Vac7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="631"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5485411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="926" mass="99760" checksum="4BC2523E56864F74" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7D9</accession>
    <name>A0A9W9X7D9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_005439</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790235.1">
        <property type="nucleotide sequence ID" value="XM_056935041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X7D9"/>
    <dbReference type="GeneID" id="81625290"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF1">
        <property type="entry name" value="ALLANTOATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5485451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="580" mass="64418" checksum="FA00F2BB604EABB8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7Q8</accession>
    <name>A0A9W9X7Q8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790014.1">
        <property type="nucleotide sequence ID" value="XM_056934820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X7Q8"/>
    <dbReference type="GeneID" id="81625069"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="627" mass="69426" checksum="49020B249988BDC8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7R6</accession>
    <name>A0A9W9X7R6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pre-mRNA-splicing factor cwc15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_005632</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790428.1">
        <property type="nucleotide sequence ID" value="XM_056935234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X7R6"/>
    <dbReference type="GeneID" id="81625483"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006973">
        <property type="entry name" value="Cwf_Cwc_15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718:SF2">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04889">
        <property type="entry name" value="Cwf_Cwc_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5485644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="234" mass="26939" checksum="C537F82AC85ACA33" modified="2023-11-08" version="1">MTTAHRPTFDPAQGKEALRGPAYHQRLLPAHTHLKVRQPGQGGDADHEVRDLRAELLRAEAAHFAKKNGTPIEESTSTETTALKRHLEGPPADADAELEEDPETKRRRILEETRDIDADSDGSEQDSSEEEDSDDEDEAAELMRELEKIKKERQAQKEKEEQERAAQEEEQREVDIARGNPLLNSQDFNLKRRWDDDVVFKNQARGTEKKDGKEFVNDLLRSDFHKRFMSKYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XC51</accession>
    <name>A0A9W9XC51_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisome assembly protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peroxin-12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_003560</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790703.1">
        <property type="nucleotide sequence ID" value="XM_056933162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XC51"/>
    <dbReference type="GeneID" id="81623411"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="388"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="322"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="433"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5488670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="494" mass="55702" checksum="39DB41CC23C7F9FD" modified="2023-11-08" version="1">MEYLPSLQQEFDEQKPSLFELLAEQQLSDLLPPSLRYLLAVATHRHPRYLLRILNSYDEVYALLSLVVERYYLRTFGGSFTENFYSLKRERVLRTKNGEIPRAQVGAAGPVRDALKLHSTDIWKNLLVMVGIPYLKRKLDEGYDIHAAPHASLVMGGGPRYNPNDDLPHNATIRQRIFHYYKWFLRNIYPSVNAAYYFSILAFNLAYLFDNTKYSSPFLWLIGTRIRRLGAADHRAIAAVLDSKPASAGTRRHQRPGSGLMGLLSPQNIYPQLLTSLRYFLPASIFALKFLEWWHASDFSRQLARKATEVLELPAPVVSGLTSPAERRKAGQEEKEKKQAEQEKKASGDLKSALKSARRHQSPISATSYLPIFTVPLPPAETSSANMCPVCLNTLVNPTACQTGYVFCYVCIFHWLNGEHQRQIDFMNGEGAGAPWEEEITGDDDPVKSGSDGTEDGDRITRKRAGKWESGKGRCPVTGRRVLGGTDGLRRVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XC75</accession>
    <name>A0A9W9XC75_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Chromosome condensation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_003605</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:76160"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790748.1">
        <property type="nucleotide sequence ID" value="XM_056933207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XC75"/>
    <dbReference type="GeneID" id="81623456"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="FluC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259:SF1">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5488715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="52746" checksum="47B997B87D432B86" modified="2023-11-08" version="1">MVGHAASDRIHAPAADLVPEDPEDSPLTEVIAPEPVERVASQRSQWDAAHRSVEKEHEDATRGHEGRSPTAAVTSAASDDDYDPALTETTAPQPVAPTASQRQQWYSSRPAEDTTPVESAPATSVSKRATHLYTISYLVFFSIFGTLARLGLQALTFYSGAPVVTGVIWANVTGSFLMGFLIEDRKLFQQEWGNPPTPPSQHAAPRKSETEHDAEQRLKSHKAVKKTIPLYIGLTTGFCGCCTSFSSFLRDVFLALANQLPDPSLPPGTGIAPRNGGYSVMALLAVIILSVSLSVSALIVGAHLAVGLVRVTPTIPFKWTRRVVDRLMVPLAWGCWLGAVLLAIWPPDRHAADTWRGRAVFAVVFAPVGCLIRYYVSMALNGRVPWFPLGTFAVNMLGVAVEGLCYDLQHVSGLGAGVGAWTGCQVLQGLMDGFCGCLTTVSTWVAELNGVTRRRQAYFYGTVSVGVGLGLMVVIMGSLLWTRGFDGPVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCC3</accession>
    <name>A0A9W9XCC3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras-related protein Rab-6B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003689</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790832.1">
        <property type="nucleotide sequence ID" value="XM_056933291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCC3"/>
    <dbReference type="GeneID" id="81623540"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000229">
        <property type="entry name" value="Probable Ras-related protein Rab-6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5488799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="209" mass="23352" checksum="061FF6A1BD68D929" modified="2023-11-08" version="1">MASSSGVGSYSNPLKKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSSVAVVVYDISNAKSFQNTRKWIDDVRGERGNDVIIVLVGNKTDLNDKREVTTAQGEEEAKKNGLMFIETSAKVGHNVKQLFRRIAQALPGMDGEAKQGESTMIDVNIHPKETTSNDSCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCV9</accession>
    <name>A0A9W9XCV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PH-response regulator protein palH/RIM21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003989</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the palH/RIM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791132.1">
        <property type="nucleotide sequence ID" value="XM_056933591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCV9"/>
    <dbReference type="GeneID" id="81623840"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014844">
        <property type="entry name" value="PalH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH/RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH_RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08733">
        <property type="entry name" value="PalH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="496"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="539"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="736"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="828"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="575"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="631"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="751"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="844"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5489099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="859" mass="94694" checksum="D9058B873A3B15C8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCW0</accession>
    <name>A0A9W9XCW0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791098.1">
        <property type="nucleotide sequence ID" value="XM_056933557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCW0"/>
    <dbReference type="GeneID" id="81623806"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF5">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5489065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="38562" checksum="2F565D6217D61569" modified="2023-11-08" version="1">MHASSRPIRSLRRLLLKCPTTRGSSPSPPSCSAGIKEYLVALRSDDRPRAYRARTPRKHGYYDRNCCSTQLHTSKLAPPSPVISRRSFSQQAIRTMSSAPDATRDVDPRYQQLFTELEQRFASTSLGPDKWYILAISTLAASPDPERADQLYLHLCAQPNNTTPSARQALVRRLREALIKSVPIVGVCKPIEAILSIGKIERDEDKDYSFTREGWQCDQANHERGTAWMQKLYTRDRTGTVNLFAAHQDFKWLSEEITYGLYLSDRQVLDDVDTQLVVLPGIMSQNLPNETHWHIRGTRRLGVPKEEVQVIWDCVQLVAKFFDVTLNKVPTVDQVEPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XD38</accession>
    <name>A0A9W9XD38_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-type lectin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_003553</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790696.1">
        <property type="nucleotide sequence ID" value="XM_056933155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XD38"/>
    <dbReference type="GeneID" id="81623404"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06903">
        <property type="entry name" value="lectin_EMP46_EMP47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035661">
        <property type="entry name" value="EMP46/EMP47_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF28">
        <property type="entry name" value="LECTIN, MANNOSE BINDING 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040826559" description="L-type lectin-like domain-containing protein" evidence="8">
        <location>
            <begin position="17"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="9">
        <location>
            <begin position="27"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="305"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5488663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="428" mass="47197" checksum="538225B10788E443" modified="2023-11-08" version="1">MRCLSTLTFFAIGATAQVIEGTSFGHGTTLTSLPEFLPIETQFRVGAWGERVTYQFFCLQLSDKVILTPPYPGNTRGSAWAQNPVSQQEWSAEFQFRASGPERAGGIMQLWYAKDGQTRVGTSSIYTVGPFDGFALVVDTHGGRGGSVRGFLNDGTVDYKSHRSVDSLAFGHCNYAYRNLGRPSSIKVKHTNSVFEVTVDDKVCFSTGKINLPTGNTFGLTAATPETPDSFEVFKFILTSGSGQGQTAQSPQDSTQQQQQHIVNHNQVPVGGDSKTSGSDSSNAAQFVELHSRIQLQNKAINNIIQEMKAQAGKTEARHNEAMQKLVAKEQIATLDARLQRIESLLQNIQRDLEGKDYSGRFNQLQDTLRSSHLSLTENLQSHFISAITASTPRMGFFIFLVIAFQALLATAYVIYKRRRANMPKKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDX1</accession>
    <name>A0A9W9XDX1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CIA1</name>
        <name evidence="6" type="ORF">N7539_004490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDX1"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="197"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="461"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5489600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="477" mass="52070" checksum="12DC1BA2C82D7009" modified="2023-11-08" version="1">MAQSSITLLSDLTPPSLERAWLTAPHPTLPIVATCSSDKTVRIYSLTNFKLLSTITGGHKRSVRTAAWKPHVQGESVLATGSFDATVGVWRRWDSYGRAEGGSVAWDSHANANTEVDVGAGANGSSRAAAARNGTDEDDDDEEWRFAVLLDGHDSEVKSVSWSASGMLLATCARDKSIWIWEDLDDGDNNFETVAVMQEHGGDVKCVAWHPAEECLASGAYDDTIRIWREDLDDWGQVACLKGHGGTVWFLDWESVENVPSSSTNTNINGEMDEEKPTELAKQWREHHAMSGPRLISCSDDRTVRVWRRLPKEGHAFGANASATTGIPSIIRPTGSDESWVEDAVLPHAHELTIYAVAWSRRTGLVASAGADGRIVVYEERLVQDSKQTKSTSTTDDPADTVDTVDTEITQQKSAPPLQTEWTILAVMDGAHGIYEINHVAWAKRADRGSAAGREAAEEVLVTTADDGSVKVWTFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE81</accession>
    <name>A0A9W9XE81_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_004138</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791281.1">
        <property type="nucleotide sequence ID" value="XM_056933740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XE81"/>
    <dbReference type="GeneID" id="81623989"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000004">
        <property type="entry name" value="Probable prefoldin subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="114"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5489248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="18082" checksum="2B21CEC178C1D637" modified="2023-11-08" version="1">MASSEGGAPAGQVNLASLTVPQLRSVQTRLTSELEHLTSSHTKLRAAQAKFRDCVNSINDGVKGSAKKGTDGREEILVPLTSSLYVKGRLTDREKVLVDVGTGFYIEKTAEKAIAFYNDKVKGLDANLQELEKIVQGKSQQLRIVEEVLRQKMLSGEGAPAQTAGVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEH6</accession>
    <name>A0A9W9XEH6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation machinery-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_004448</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with the 40S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DENR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791591.1">
        <property type="nucleotide sequence ID" value="XM_056934050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEH6"/>
    <dbReference type="GeneID" id="81624299"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000014">
        <property type="entry name" value="Translation machinery-associated protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="SUI1" evidence="8">
        <location>
            <begin position="118"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5489558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="214" mass="23633" checksum="339F1F58EA5B6AB2" modified="2023-11-08" version="1">MAEVADSGPIESQARRVVYCGVCTLPPEYCEFGGTAKKCEEWLKANHEDLWSRLHSEGMNERLTSNSRPTDLKDALNANLSELSVSVQERAAKDAAKKEAKAAQTEARDAERKAASKIQIKRVERNKRKYVTVIIGLEIFGLENKKLAKELGKKMATGSSVTRSPAGTEEITVQGDVSEDVKEWLLENYGSKVPEANIELIEDKKKKKAEGPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF29</accession>
    <name>A0A9W9XF29_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dual-specificity kinase</fullName>
            <ecNumber evidence="1">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_002325</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791887.1">
        <property type="nucleotide sequence ID" value="XM_056931928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF29"/>
    <dbReference type="GeneID" id="81622177"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000612">
        <property type="entry name" value="Serine/threonine-protein kinase AFC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="331"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5490758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="695" mass="76885" checksum="BCBD3EB9547D3C85" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG58</accession>
    <name>A0A9W9XG58_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792282.1">
        <property type="nucleotide sequence ID" value="XM_056932323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG58"/>
    <dbReference type="GeneID" id="81622572"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF22">
        <property type="entry name" value="CAPSULE ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="1">
        <location>
            <begin position="330"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="657" mass="74839" checksum="4C21562857350E8D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG76</accession>
    <name>A0A9W9XG76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bifunctional cytokinin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792813.1">
        <property type="nucleotide sequence ID" value="XM_056932854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG76"/>
    <dbReference type="GeneID" id="81623103"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000018">
        <property type="entry name" value="Lysine decarboxylase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00730">
        <property type="entry name" value="Rossman fold protein, TIGR00730 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223:SF70">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102405">
        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5491685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="244" mass="25884" checksum="260952852907A7C3" modified="2023-11-08" version="1">MAENKPAVVCVFCGATSGKDPVHMGAARALAYEFHKHNIRLVYGGGTTGLMGEVAKTLVSLSGPKAVHGVIPRALVKVAVKGVGNPADHSKANGNGVSPTGGKAAEREVSEALEGEEIPESEYGVTTIVRDMHTRKRMMAELVLQGGPGSGFVSLAGGFGTIEEVMEMTTWNQLGIHRVGVVLLNINAYWDGLLAWVRNAVENGFISAENGAILAEARTVEEVVPKLLQYQCSADRFALNWGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG98</accession>
    <name>A0A9W9XG98_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792710.1">
        <property type="nucleotide sequence ID" value="XM_056932751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG98"/>
    <dbReference type="GeneID" id="81623000"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5491581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="23369" checksum="436D73831F85687F" modified="2023-11-08" version="1">MNKGKAIKVNLNYFRPLLRDLGVKDKDGIVVIDIGAILMEDREREKERMQGDGVDVQKLSETDFLVGCLTCVVSALRDVDWLPESFDCLQIPSENKILLLLMAKTRLDLIPTVLFDDYLSKCLYYTVTWILTCASGLPGVGKIFTVELEFIFKIVKYFKAVLLLDEADAFMSFEEISGRLFCLRYVRCKDQRLLRSTTSDDWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGJ2</accession>
    <name>A0A9W9XGJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792967.1">
        <property type="nucleotide sequence ID" value="XM_056930936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGJ2"/>
    <dbReference type="GeneID" id="81621185"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="824"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="723"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="914" mass="99173" checksum="96E899C3DC61F29E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGP3</accession>
    <name>A0A9W9XGP3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein RTM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_001300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792934.1">
        <property type="nucleotide sequence ID" value="XM_056930903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGP3"/>
    <dbReference type="GeneID" id="81621152"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF31">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5492554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="297" mass="32945" checksum="C54CC2987368F9BE" modified="2023-11-08" version="1">MSTSSSNGGIDFALYRYTPSIVAAIIFAAIFLGITVVHSFRLWQNRTYFFIPFIIGLLFECAGYIARVFSHYDTKALGPYIVQTMLILVAPPLFAASIYMSLGRVIVGLDCQEYSLVPVRFLTKIFVIGDVISFLLQCGGGGYMAAGSVSAMNMGANIVIGGLVIQLLFFGFFVIVSAVFHWRVKRNSRNESHAMKGLGKNWEPIMWALYAACFLILVRSIFRVVEFVEGNDGYIMKREYLLYIFDACLMALAGSVLVIIYPGSFLGRERGTRDSSLQLMSTTEEDISTQKSTAYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGS3</accession>
    <name>A0A9W9XGS3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_002884</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792446.1">
        <property type="nucleotide sequence ID" value="XM_056932487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGS3"/>
    <dbReference type="GeneID" id="81622736"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000011">
        <property type="entry name" value="Cdp-diacylglycerol-inositol 3-phosphatidyltransferase pis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5491317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="320" mass="35529" checksum="201F1546FF6C75AF" modified="2023-11-08" version="1">MSARTRRQKAALDVSADDGEVLDAGNGNGNLGVPSAAPKSTRRASSKKRSRSAVRVEEDNEENIFLFAPNLIGYFRVVLAFASLYYMPLHPRTCSLLYSVSCLLDALDGYAARYFNQSTTFGAVLDMVTDRCTTSCLLVFLSSAWPRWAIVFQGLICLDLASHYMHMYATLSMGGSDQSHKKIDSSRSWILYQYYHSRVVLFICCALNELFFIGLYLLSFSSPILSPSLLQPVGDTQPSSAQPGNPAHPIPTSLFASPWSAGALEMARANKIDSFWPWVITGIAAPVMLFKQFVNVVQMVNASRWLAEGDRLNRRANRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGS8</accession>
    <name>A0A9W9XGS8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793133.1">
        <property type="nucleotide sequence ID" value="XM_056931102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGS8"/>
    <dbReference type="GeneID" id="81621351"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="107" mass="11729" checksum="AC670684BC155CF5" modified="2023-11-08" version="1">MRSIKNQKGLWKPHNGKSVDNLVVILYRPSARTTTWERDARPSSITRRGCQIVVDTRVGREALLQLSSQLPAPSSQLSARAPQRPTGGTRVAAKKRLAPGSGLVPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH82</accession>
    <name>A0A9W9XH82_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793367.1">
        <property type="nucleotide sequence ID" value="XM_056931336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH82"/>
    <dbReference type="GeneID" id="81621585"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="73" mass="8330" checksum="12DB463E3F625427" modified="2023-11-08" version="1">MKKKKKKKKKKKKKELMQTGEGRKWDVVVCIAECVLRSRVSRGGNGPDPSGRLEARVQVEPRGSREVFGRPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHU6</accession>
    <name>A0A9W9XHU6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_001993</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793627.1">
        <property type="nucleotide sequence ID" value="XM_056931596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHU6"/>
    <dbReference type="GeneID" id="81621845"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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            </authorList>
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        </source>
    </reference>
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        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <comment type="caution">
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAJ5495666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="87" mass="10238" checksum="CCB1AF9F3DC3A7FC" modified="2023-11-08" version="1">MMSTAIQTPRDLLSSYTVSQMSKDERRWSRCHPTHILNFIQMPSMYSTKWIFTQASARPYTVTADLDLQETDLRSHEYVYDADLCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMC9</accession>
    <name>A0A9W9XMC9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Initiation-specific alpha-1,6-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_000797</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794694.1">
        <property type="nucleotide sequence ID" value="XM_056930401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMC9"/>
    <dbReference type="GeneID" id="81620650"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF8">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5495681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="43823" checksum="99F975DBDE56285C" modified="2023-11-08" version="1">MLRSPYYMVILIGLFLITLFWLAARDGSTGSSWSLPYGSCSCAEDINDGIRIKPHNSLPSPSTTPSTSTSPSQPKNSAAATPTRIDEDLPSSRLTPQSYYLPFRPSHQLARLPFPAKVWHKAGPNGISEDRQRDMQSWLAVNPSLRHETFTDGSAEYYVKEKFAKFPEIIDTYQDMQVPILKADFLRQLILYAEGGVWSDLDVTCHEPIDTWIPEKYKSQTNVVVGLEFDGNQFASWTIMAKPRTNHIASVIDYIMEKLDETALRANTTVAKITMKDIEDVVALTGPQAMTQAIFRSLSIDLGQPISGIDVADLRAPILLHDVLVLPNAAFAAMQGGWPEDRGPYLVEHHYAGSWKNDDGGETSTDKAAESANEQTDDPAVSSESEEIKSEIRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMV3</accession>
    <name>A0A9W9XMV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_001048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794945.1">
        <property type="nucleotide sequence ID" value="XM_056930652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMV3"/>
    <dbReference type="GeneID" id="81620901"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14232">
        <property type="entry name" value="GAT_LSB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16980">
        <property type="entry name" value="VHS_Lsb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044103">
        <property type="entry name" value="GAT_LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF1">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VHS" evidence="3">
        <location>
            <begin position="18"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5495932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="390" mass="43554" checksum="33DA1D982004CA3E" modified="2023-11-08" version="1">MFSSAKPFSAVSVQIEVLTSEQYEVEDSSGIVDLIEVVRIQGSGPQEASRALRKKLKYGNIHRQLRALTILDFLIQNAGERFLREFADEPLLERLRIAGTDPVSDPLVKEKCKQLFGQWAVTYKDTPGMQKIAALYRQLPKRKQPATQAKAKVLREGSGQSETPMGHTVTISAGNGPATTLSSPKQKSKSKDKKREKKLSISPKNFNLERERPQIYETIASASVASTNLLNSLKLVNRETTRVSDDAECSHRFNMCKKLRHQILRYIQQVESEEFLGGLIHANEELVTALMAFEVLDKSLDYDSDSDDDVLSGNWRSRSEMHSDMNDSFSGLSINPPRPPRPSPPVASSSRPPPESESESEESEDDDENNPFGDRNAIKTPGLDKSGYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ10</accession>
    <name>A0A9X0BJ10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MINDY deubiquitinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_009529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785619.1">
        <property type="nucleotide sequence ID" value="XM_056939124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJ10"/>
    <dbReference type="GeneID" id="81629374"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007518">
        <property type="entry name" value="MINDY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033979">
        <property type="entry name" value="MINDY_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063">
        <property type="entry name" value="NF-E2 INDUCIBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04424">
        <property type="entry name" value="MINDY_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MINDY deubiquitinase" evidence="2">
        <location>
            <begin position="317"/>
            <end position="596"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5466573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="794" mass="86870" checksum="73635BC3159C8D60" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJG3</accession>
    <name>A0A9X0BJG3_9EURO</name>
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        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_008976</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5469358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056938571.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81628821"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF21">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="382"/>
        </location>
    </feature>
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            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="59"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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        </location>
    </feature>
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        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5469358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="514" mass="56970" checksum="E77B88382A854A4F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJK8</accession>
    <name>A0A9X0BJK8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homologous-pairing protein 2 winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_009081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056938676.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81628926"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
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            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5469463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23306" checksum="F6C62F549D9DDE63" modified="2023-11-08" version="1">MAPRKEKETKGNSAETDVQNSAKLTETVWLAQAGKILKDLHQKGEIEGRTAGKQIVYHALQKSSDPASPELLTALVQEITTLQEELSIIKANEKKARTALATLQAKPRLSALREEIRQLGMERDAAQARVHENRSDGGDDHQPQISPTARAQLERDWTQWQRHARLRRRICRELWESCSEVLPEGVATAAELWESVYSCSLFFSNVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJL8</accession>
    <name>A0A9X0BJL8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_009096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786068.1">
        <property type="nucleotide sequence ID" value="XM_056938691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJL8"/>
    <dbReference type="GeneID" id="81628941"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5469478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="92" mass="10012" checksum="8FE9AA5028CA64AD" modified="2023-11-08" version="1">MDAAQWKAWLARSVPASVFSTEVTIEGAFQGSDLLLSSIPTEIWTMMPANDPSYTFVGHVTSSNLLLQQPSRLFSHFRGAVNGDKAGIEGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BMA7</accession>
    <name>A0A9X0BMA7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786663.1">
        <property type="nucleotide sequence ID" value="XM_056938281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BMA7"/>
    <dbReference type="GeneID" id="81628531"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="2">
        <location>
            <begin position="209"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5472117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="407" mass="47832" checksum="5E6D4C4B962BB869" modified="2023-11-08" version="1" fragment="single">MPRTRAGLPVPSPPEPRGPISTAPRPPPQPPNDQPRRKNCELDVNLRTQITTLKDVAKWSYRQMHEKYPHIPPSTIKMTCFRSRIRHKEESRERSGRPKILDDDDRQKILQKIHENPRSSYDDLLSEVDHKCKDLSESMSRRLDVYTCERICELKFTLKWGARRIQKYRFPDIPLSTISYTLTMKRKRMNGASLARAGPPRKLSEEDRDRVYDAIQTNPSITREDLLKEVDYKVKTSSIWRLTHEMGLRKWRKMDRPYLTPEHAAERLSWALTYRHYTPEDWKRVFWSDETTIERGQGARKEWTFIPPWQQLQERSEGVQMSLSKGKQIKQMFWACFAGSPRKTGLIPLYGDPEAEKKGITKEVIHDLYQRILPTLLDNEDAIFQHDNAPTHTALIVRALLRELNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNA7</accession>
    <name>A0A9X0BNA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoglucanase-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786760.1">
        <property type="nucleotide sequence ID" value="XM_056937668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNA7"/>
    <dbReference type="GeneID" id="81627918"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040896252" evidence="1">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="77" mass="8524" checksum="A54FDEFE51BD7973" modified="2023-11-08" version="1">MYKVLAILSLADLVVCHGHIPNIVINGVFYQGWNIGSFPYLSNLPLVYRISFATCMYTTINAKGYIVVASADKINVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNK6</accession>
    <name>A0A9X0BNK6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1917-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_007770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0696 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787236.1">
        <property type="nucleotide sequence ID" value="XM_056937371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNK6"/>
    <dbReference type="GeneID" id="81627620"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015034">
        <property type="entry name" value="Bles03"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977:SF1">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08939">
        <property type="entry name" value="Bles03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5475483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="33660" checksum="5F37FB9FB9A71426" modified="2023-11-08" version="1">MTPGFRSEDVFSDESSFYGDDEEQTRLKELDATFDPEPYWANVHPRLLSTIQYTSTAPQHKAEPEDSPAHDNDAEGSSFRPRDKRGRAEPIAAFLSRLPPSRTRSSDAGPWIWMRKSRSQGGDGDIATLVREGNALLQAYEEEASELRSAHDKSGAKTKAALTRKLNPLRRTLEQDIFGLAKETGVTAGKWMLFPSVEHVDSAWKKVVTALDKGELGDAAKVATDDGSGQARLICVYTDDFSDKKDVKRVLRSLVEQGLVDKESRPIYYKCDAYTYLDIKSNNEYGLKASLFSSREVLSGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNM8</accession>
    <name>A0A9X0BNM8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787135.1">
        <property type="nucleotide sequence ID" value="XM_056938043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNM8"/>
    <dbReference type="GeneID" id="81628293"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="76"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="229" mass="26649" checksum="E896BC71065BAB86" modified="2023-11-08" version="1">MLEALCERLEKPDLYQDEMAVFLWDEFRVLVTSYSIRVLASAGWSEKAARRIARERNTELRDYNLHTISSFQSYHLVDVDESGCDKRVGFQRTGWSPLGVTPVQISRFHRGQRYQILPAYAQDGVVFSRVFRGLTDAVVSEDFIRQLLHHCGRWPEPKSVLVMDNASFHRTEGVRQIFLAAGVKLVYLPPYSTDLNPIEELFAELKAFIKRRWLVYEENPEQGFNNFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNS4</accession>
    <name>A0A9X0BNS4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">N amino acid transport system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_007182</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787582.1">
        <property type="nucleotide sequence ID" value="XM_056936783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNS4"/>
    <dbReference type="GeneID" id="81627032"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="65"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5477038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="478" mass="51512" checksum="C98C19BFFE666081" modified="2023-11-08" version="1">MSDLTNATAHVAVDESVAGARSKKSLETSDGPPPPLPASDFDMKEYDLDEAEQRIAAAGEAKYNRLSWKQLTLLLIVDAVALGALSIPHAFATLGMIAGVVCCVGIGLIAVYTSWIIGKVKLAFPSVQHYGDAGGLLMGRFGYEFVSAVFVIQLVFVVGSHCLTGTIAFANITESTICSLIFGVASMIILFLFTIPSSFADITFLGYIDFVSILGAIGITMIATGIQSSNAPGGLSAVPWSAYPKENITFTEAYVAIGDIVFAYSFAACQFSFMGEMHTPEDYTKSITVLGLIEIMIYTLTGAIIYAFVGPTVQSPALLSAGTTVSRIAFGVALPVIFISGSINCIVVGRLVHARVYKNSMIRYINTAQGWMTWILFVAIITVIAWVIAEAIPFFTDLLSIISALFTSGFSFYLPPVMWFFLLCKGKWYSRENLPTAIINFLVFLMGVAVLVCGLYSSIDDIRNSYRTGKVRSPFTCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BP83</accession>
    <name>A0A9X0BP83_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_007345</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787745.1">
        <property type="nucleotide sequence ID" value="XM_056936946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BP83"/>
    <dbReference type="GeneID" id="81627195"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="494"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="549"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="652"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="425"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5477201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="684" mass="77584" checksum="011981EC2094F138" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSF7</accession>
    <name>A0A9X0BSF7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788338.1">
        <property type="nucleotide sequence ID" value="XM_056936403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSF7"/>
    <dbReference type="GeneID" id="81626652"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="35"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5480908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="343" mass="39008" checksum="BD0B1BD0D35A0195" modified="2023-11-08" version="1">MTKRDQDGIPKPSSEYQTVNMTEIVRDAYDHPNYSDLVIECGKHTFPVHKMIVCPQVDFLRAACCGNSKTEINGKIRVRHVEPAVMDKMVQFLYTTDYTMDLLPPSDDDEVEIKSETAEKSPQLVAASIETNQAVPVNLPEVPIRPDTHELPTPVNKPASIFQGAEVFTQRSDNDDGNEEEEEEEKEEVEGKGSESESDENDNNDPDEFVEICLVNPAFFHVRMYKWATKYKIKPLCYLAVVKFREQIRKGILKDYLEDLIYEVYSDEDRDTYEGMLSGALVAEVVTLVFYSRFKGLDILSTAFLKESPGFTFDLCCAIMKKIGRLPERSMLEFLGLGRPVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSY7</accession>
    <name>A0A9X0BSY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptide transporter PTR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_007025</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788561.1">
        <property type="nucleotide sequence ID" value="XM_056936626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSY7"/>
    <dbReference type="GeneID" id="81626875"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="614"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="621"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5481131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="634" mass="70921" checksum="F8C9E5BC2D83FD51" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSZ3</accession>
    <name>A0A9X0BSZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789009.1">
        <property type="nucleotide sequence ID" value="XM_056936085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSZ3"/>
    <dbReference type="GeneID" id="81626334"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5483037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="69" mass="7927" checksum="02E70AEF1E2CBC11" modified="2023-11-08" version="1">MPPPPLVVELPVSEKLTSLGLWPRIRVLNQRGVVDDLERRSIKQSRLYSGISQIQQLLCIHYSDWSGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSZ6</accession>
    <name>A0A9X0BSZ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carotenoid oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_006498</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789024.1">
        <property type="nucleotide sequence ID" value="XM_056936100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSZ6"/>
    <dbReference type="GeneID" id="81626349"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF89">
        <property type="entry name" value="CAROTENOID 9,10(9',10')-CLEAVAGE DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
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            <position position="421"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="663"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5483052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="687" mass="76854" checksum="38A380F89A1BA895" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BU35</accession>
    <name>A0A9X0BU35_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentatricopeptide repeat-containing protein-mitochondrial domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_005902</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056935504.1"/>
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    <dbReference type="GeneID" id="81625753"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="PPR-containing_protein"/>
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    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057027">
        <property type="entry name" value="TPR_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939">
        <property type="entry name" value="MEMBRANE-ASSOCIATED SALT-INDUCIBLE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939:SF1">
        <property type="entry name" value="OS04G0684500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23276">
        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Pentatricopeptide repeat-containing protein-mitochondrial" evidence="4">
        <location>
            <begin position="353"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="498"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="602"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
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            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="673"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5484106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="682" mass="77226" checksum="854E2F7D63E2B8EF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUE0</accession>
    <name>A0A9X0BUE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nitrogen regulatory protein nrfA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_004714</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789510.1">
        <property type="nucleotide sequence ID" value="XM_056934316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUE0"/>
    <dbReference type="GeneID" id="81624565"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011420">
        <property type="entry name" value="AreA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07573">
        <property type="entry name" value="AreA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="13">
        <location>
            <begin position="697"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="145"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="605"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="654"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="748"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="775"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="806"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5484726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="905" mass="96447" checksum="B0CF7A07CFE27068" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUE9</accession>
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            <fullName evidence="1">phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase</fullName>
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    </protein>
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        <name evidence="6" type="ORF">N7539_005900</name>
    </gene>
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        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
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    </dbReference>
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        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
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        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
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        <location>
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            <end position="420"/>
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        <location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5484104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="565" mass="63086" checksum="8858805571D4F9BC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUG0</accession>
    <name>A0A9X0BUG0_9EURO</name>
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        <recommendedName>
            <fullName evidence="3">DUF7703 domain-containing protein</fullName>
        </recommendedName>
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    </gene>
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        <name type="scientific">Penicillium diatomitis</name>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF4">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
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            <end position="34"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5485158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="318" mass="35864" checksum="9612F2D6E755760B" modified="2023-11-08" version="1">MRGETGPVHLSQAMAMVMAGLLTLSCWNVLEISFYILTTFRRYRGLYFWSMVIATFGILLHAVTGFLRYFALAPNLPMCFLICLGWYAMVTGQSVVLYSRLHLVTTHEYYRRWVLVMIIVNFCILHIPTTILFLGANNGVENFVHPFSIYEQIQLVGFALQETVISALYVWETTTSLRPLLSLKGPRGTRVIINVVLVNVIAVLLDAALVTIEFTHHFDVQTTFKPVVYSIKLLLEFIVLNSLLAAIQTPAGSFHNPSSEHGQPDVFVRGLDSIHTFDRPSNPSLHDPERLVSGDRRTSSGESVVKPLEIWNSHFSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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    </gene>
    <organism evidence="10 11">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056934512.1"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13919">
        <property type="entry name" value="ASXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEUBAD" evidence="9">
        <location>
            <begin position="35"/>
            <end position="155"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="374"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="497"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="461"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5484922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="656" mass="73626" checksum="5797A94850E339D5" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUK0</accession>
    <name>A0A9X0BUK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Importin alpha re-exporter</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">N7539_004924</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001148312">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Importin N-terminal" evidence="8">
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            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="958" mass="108430" checksum="A082B2AA2E4A03CD" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUM6</accession>
    <name>A0A9X0BUM6_9EURO</name>
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        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_005014</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789810.1">
        <property type="nucleotide sequence ID" value="XM_056934616.1"/>
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    <dbReference type="GeneID" id="81624865"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5485026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="661" mass="73403" checksum="ADBA02A246B8DFAF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUT5</accession>
    <name>A0A9X0BUT5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC multidrug transporter atrF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_004938</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>voriconazole(in) + ATP + H2O = voriconazole(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61912"/>
            <dbReference type="ChEBI" id="CHEBI:10023"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:61913"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789734.1">
        <property type="nucleotide sequence ID" value="XM_056934540.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81624789"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001650">
        <property type="entry name" value="ABC drug exporter AtrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="628"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="805"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1224"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1258"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1296"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1336"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1367"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1490"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1517"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="198"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="893"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="858"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="873"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5484950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1550" mass="172961" checksum="11A265AB2A8CC185" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXH9</accession>
    <name>A0A9X0BXH9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dihydrosphingosine 1-phosphate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_003706</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790849.1">
        <property type="nucleotide sequence ID" value="XM_056933308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXH9"/>
    <dbReference type="GeneID" id="81623557"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03388">
        <property type="entry name" value="PAP2_SPPase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="10">
        <location>
            <begin position="90"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="405"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5488816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="519" mass="57820" checksum="690CE15B0A5C4B90" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXM8</accession>
    <name>A0A9X0BXM8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_003810</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790953.1">
        <property type="nucleotide sequence ID" value="XM_056933412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXM8"/>
    <dbReference type="GeneID" id="81623661"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000018">
        <property type="entry name" value="Protein arginine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007857">
        <property type="entry name" value="Arg_MeTrfase_PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015894">
        <property type="entry name" value="Skb1_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="11">
        <location>
            <begin position="39"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="10">
        <location>
            <begin position="371"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="12">
        <location>
            <begin position="578"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="322"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="496"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="627"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="793"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="801"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="545"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="554"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="406"/>
            <end position="407"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="495"/>
            <end position="496"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for specifying symmetric addition of methyl groups" evidence="7">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5488920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="837" mass="92293" checksum="E9DFC4B631C3F309" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY51</accession>
    <name>A0A9X0BY51_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791539.1">
        <property type="nucleotide sequence ID" value="XM_056933998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BY51"/>
    <dbReference type="GeneID" id="81624247"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="873" mass="98960" checksum="0A35697A515CC4A6" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY69</accession>
    <name>A0A9X0BY69_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_003963</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791106.1">
        <property type="nucleotide sequence ID" value="XM_056933565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BY69"/>
    <dbReference type="GeneID" id="81623814"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000182">
        <property type="entry name" value="Outward-rectifier potassium channel TOK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF342">
        <property type="entry name" value="OUTWARD-RECTIFIER POTASSIUM CHANNEL TOK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="760" mass="84649" checksum="9502346BF9341B21" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZM5</accession>
    <name>A0A9X0BZM5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_003251</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792812.1">
        <property type="nucleotide sequence ID" value="XM_056932853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZM5"/>
    <dbReference type="GeneID" id="81623102"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.580:FF:000003">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016612">
        <property type="entry name" value="Mediator_Med6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013286">
        <property type="entry name" value="MED6_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="173"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="288"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR013286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5491684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="340" mass="37044" checksum="08FCE7DC47A03338" modified="2023-11-08" version="1">MANQAAPMEEIIWRSPQHVQMMGGYLHSNNILFYFAESAFFDPQSNNGILATQATYNESLRHVVETRATFEGKLKQMQGLEFIVSYDPLEAAARTNPNRFETEPNNIWVIRKQERRKRNGMEDDVTLLATYFVVGDTIYMAPSVASIVGNRILTAVTSISRLMKTASTLPIFTPTTGHTYLPPTARANEPGQQPAQQSKENTPMPDATQPSGAETQTSTKANLGVSAGSSSYQDTRNLAEAFNLFKRYGDEFMDEHPLTGEPGSFILSRAGETDRPVGAAAKVASKATLGTGANTPAGLRARSTTPQVRVDTPGKAQDKGNTPPSSGENKLKRKKGRVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C015</accession>
    <name>A0A9X0C015_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein cwh43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_001744</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793378.1">
        <property type="nucleotide sequence ID" value="XM_056931347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C015"/>
    <dbReference type="GeneID" id="81621596"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000031">
        <property type="entry name" value="Calcofluor white hypersensitive protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057315">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051916">
        <property type="entry name" value="GPI-anchor_lipid_remodeler"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053912">
        <property type="entry name" value="PGAP2IP_TM_1nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053911">
        <property type="entry name" value="PGAP2IP_TM_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859">
        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF1">
        <property type="entry name" value="PGAP2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23022">
        <property type="entry name" value="6TM_1st_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23021">
        <property type="entry name" value="6TM_2nd_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23226">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="137"/>
            <end position="157"/>
        </location>
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        <location>
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            <end position="186"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="523"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="611"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="2">
        <location>
            <begin position="16"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP first transmembrane" evidence="4">
        <location>
            <begin position="280"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP second transmembrane" evidence="3">
        <location>
            <begin position="454"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP C-terminal nuclease-like" evidence="5">
        <location>
            <begin position="684"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5492998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="950" mass="106247" checksum="2D8574ED6D03056B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C036</accession>
    <name>A0A9X0C036_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794756.1">
        <property type="nucleotide sequence ID" value="XM_056930463.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81620712"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021643">
        <property type="entry name" value="Mediator_Med13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041285">
        <property type="entry name" value="MID_MedPIWI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11597">
        <property type="entry name" value="Med13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18296">
        <property type="entry name" value="MID_MedPIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med13 N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="MID" evidence="15">
        <location>
            <begin position="959"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="13">
        <location>
            <begin position="1137"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="557"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="721"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="765"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="594"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="737"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="775"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5495743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1457" mass="158270" checksum="B95CC02CD3A15CB2" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2N6</accession>
    <name>A0A9X0C2N6_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794861.1">
        <property type="nucleotide sequence ID" value="XM_056930568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2N6"/>
    <dbReference type="GeneID" id="81620817"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849:SF1">
        <property type="entry name" value="YALI0E11605P"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="105" mass="11574" checksum="4C67167D33A05D4A" modified="2023-11-08" version="1">MALRLGTLPVLYGRAVARPFSTSRARLEAVPLPARKPVGAFRGGLFGFLTGAVVAGASVYYYVLGDYRVSNEMLNDDILALQNATMKLQSYIIELEDRVDHLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2U3</accession>
    <name>A0A9X0C2U3_9EURO</name>
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        <recommendedName>
            <fullName evidence="3">Spindle pole body-associated protein cut12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">N7539_000545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5495429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056930149.1"/>
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    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="213"/>
        </location>
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            <end position="349"/>
        </location>
    </feature>
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            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="665"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="96"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="466"/>
        </location>
    </feature>
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        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="667"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5495429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="735" mass="82464" checksum="3CE9B90C7841ED1D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKQ7</accession>
    <name>A0A9W9WKQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">N7539_008894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785866.1">
        <property type="nucleotide sequence ID" value="XM_056938489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKQ7"/>
    <dbReference type="GeneID" id="81628739"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="10"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5469276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="174" mass="19582" checksum="CF2439EE8FA372AD" modified="2023-11-08" version="1">MLTTKTSRPLQLFTRFMQWTSAVIVMGITSYFIHRGPHSTHLIYQEVIAVLSVVFFLPAFASPFVPNSLSKFVLAIDIVFSYLWLTAFIFAAEDYNRKACYVNSPPGFSCKKKYANEAFIFLAFIFTFFGMFLEVAGLWAYRKERSRATRAGIAPEKRGPTDPLDAPAPPAGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLW5</accession>
    <name>A0A9W9WLW5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exosome complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_009151</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the C1D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786123.1">
        <property type="nucleotide sequence ID" value="XM_056938746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLW5"/>
    <dbReference type="GeneID" id="81628996"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5469533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="264" mass="29841" checksum="31296985925E8C33" modified="2023-11-08" version="1">MSMDTADLLPLLEQLDDGVDDLEDALQPLLGSSLNKMSKNMPILDKAKIHVLTTYAIETLIFNYLRLRGVDAKQHPVWREITRVRQYFDKMKELETEPEQRTMVLDKAAAGRFIKHGLAGNNKIDLERAEKEAKERARAQVKAALLAKKAAASRNEEHVSSATSLTAQTGDDADESDEEMNIQKEDEAKDFKTGEAFIGFGDADVNDDIENKKKKKTKAKENTTRARTESAQKQGRKATKAELRQEKKDRRQKKENIRKSRGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQF5</accession>
    <name>A0A9W9WQF5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786336.1">
        <property type="nucleotide sequence ID" value="XM_056938328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQF5"/>
    <dbReference type="GeneID" id="81628578"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF6">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5471790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="60573" checksum="907EBA25FE32546A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WR18</accession>
    <name>A0A9W9WR18_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_008674</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786651.1">
        <property type="nucleotide sequence ID" value="XM_056938269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WR18"/>
    <dbReference type="GeneID" id="81628519"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF155">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="33"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5472105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="193" mass="21046" checksum="829D6EAA53C05A1F" modified="2023-11-08" version="1">MISMDTVATQRTALMLLIVIWVLTLLATACVVIRLCVRKYMHICGLDDCIIGLSMVSGIGLSFAVAATLSIHHGYGQHYKELNSEQASKALMWNVISLLLGTFVCALTKLAVAAHLDRIWGRVLSLSSRNLMWILTGMAPLFALVTIIIFITECKPLNALWAPAMVEAGQATCRDVSTLILFATFNGGEEYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WR52</accession>
    <name>A0A9W9WR52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786532.1">
        <property type="nucleotide sequence ID" value="XM_056938150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WR52"/>
    <dbReference type="GeneID" id="81628400"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="107" mass="12370" checksum="E53578B2153556E2" modified="2023-11-08" version="1">MKMDDQGILRTVARLDSRALRAEQAYAKLEQEVRSLQESLRLSKEDFDHVTRLLEIFYELNQRTGAVVDYLLRERAAPENEGEPLSIQVMLGTIFKKLGENEETEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTP9</accession>
    <name>A0A9W9WTP9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Something about silencing protein 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787051.1">
        <property type="nucleotide sequence ID" value="XM_056937959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTP9"/>
    <dbReference type="GeneID" id="81628209"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033255">
        <property type="term" value="C:SAS acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038988">
        <property type="entry name" value="Sas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029184">
        <property type="entry name" value="Sas4_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422:SF1">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15460">
        <property type="entry name" value="SAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Something about silencing protein 4" evidence="2">
        <location>
            <begin position="340"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5475293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="647" mass="71844" checksum="1578379D85A4AEF3" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTT9</accession>
    <name>A0A9W9WTT9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_008435</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787127.1">
        <property type="nucleotide sequence ID" value="XM_056938035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTT9"/>
    <dbReference type="GeneID" id="81628285"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5475369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="81" mass="9385" checksum="4E7BAFB4616D1E6D" modified="2023-11-08" version="1">MEISGSHSRRSNASNATEADVHRCERCKQRKTRCDREFPACQRCRRLDVRCEYAGRKRPGFPAGHRQLLEEKLRALAQSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTX2</accession>
    <name>A0A9W9WTX2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Choline/ethanolaminephosphotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_007742</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787208.1">
        <property type="nucleotide sequence ID" value="XM_056937343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTX2"/>
    <dbReference type="GeneID" id="81627592"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5475455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="52213" checksum="21F6EE28F4AA0410" modified="2023-11-08" version="1">MVYIRQHVLPNLRNYKYAGVDHSLVSRYVLKPFYSNVFRAPNSLGGLPETSFGPDISMVHGSFPPRDRDRGGVIDGREDGVLIQLLLLLSRYRPNLITLTGFMFVVFNFLTVMWYNPGMDTDCPPWVYASCAIGMFLYQTFDAVDGMQARRTRQSGPLGELFDHSVDACNTALGVLIFAAAMNLGNSWMTILCLFGSTMTFYVQTWDEYYTKVLTLGVISGPVEGVLTLCTVYAITAYQGGGSFWHQPMMETVGVTKPSFLSQQVYEMPFTQWYLVYGAFVLFFATGSSIWNVMQVRRQRGQDPYTSLYGLLPMVAIWTLVPAYLYLQPTILESYSIPFSLYVGLVNAYAVGRMIVGHLVQSGFPYHNILLYPLALAVLDSAGPAVDLWAAPLLGHGPYQIMFVFVCLGLSVGVYGSFVYDVVTTICDYNDIWCLTIKHPFVEETERKTENDAIKVAVESTQKKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTX8</accession>
    <name>A0A9W9WTX8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_007717</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787183.1">
        <property type="nucleotide sequence ID" value="XM_056937318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTX8"/>
    <dbReference type="GeneID" id="81627567"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="4">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="32"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5475430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="107" mass="11836" checksum="2BCA90DBC4F8583D" modified="2023-11-08" version="1">MPVEELTSMQDFLDKVLNAQGPVVIDAWATWCGPCRMVAPVIEKLSDAYPQIKFYKLDVDAVPDVSQELGVRAMPTIFFFKDGGKVTEVVGTHLGEIDTHVKALVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUH3</accession>
    <name>A0A9W9WUH3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_007095</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5476951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787495.1">
        <property type="nucleotide sequence ID" value="XM_056936696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUH3"/>
    <dbReference type="GeneID" id="81626945"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="beta-trefoil_MIR_PMT2-like"/>
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    </dbReference>
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        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
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        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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            <begin position="50"/>
            <end position="72"/>
        </location>
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        </location>
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        </location>
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            <begin position="401"/>
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            <begin position="1"/>
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    </feature>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
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            <dbReference type="ARBA" id="ARBA00045085"/>
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            <dbReference type="ARBA" id="ARBA00045102"/>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50919"/>
        </source>
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            <dbReference type="EMBL" id="KAJ5476951.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
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    <sequence length="741" mass="84463" checksum="C7067C51A43885D0" modified="2023-11-08" version="1"> </sequence>
</entry>
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    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="EMBL" id="KAJ5477015.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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        <name type="scientific">Penicillium diatomitis</name>
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            <strain evidence="2">IBT 30728</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="387"/>
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            <end position="426"/>
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        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
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        <location>
            <begin position="507"/>
            <end position="547"/>
        </location>
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        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="596" mass="66303" checksum="A7EFA0C6C432E41A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVD5</accession>
    <name>A0A9W9WVD5_9EURO</name>
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        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_007533</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787933.1">
        <property type="nucleotide sequence ID" value="XM_056937134.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81627383"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004104">
        <property type="term" value="F:cholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF3">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041015218" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="168"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5477389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="676" mass="74686" checksum="CCA93F68692A22D1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1J2</accession>
    <name>A0A9W9X1J2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ZIP Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_006567</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788103.1">
        <property type="nucleotide sequence ID" value="XM_056936168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1J2"/>
    <dbReference type="GeneID" id="81626417"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040939896" description="ZIP Zinc transporter" evidence="7">
        <location>
            <begin position="19"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5480673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="50926" checksum="C937F660A1AC5F53" modified="2023-11-08" version="1">MYLLKSFIIAWGAVGVYAATATTSAVLSSITGCHSHGADILCFDQHGDEVRVEAVSTSESAVPAQYTGCHEHGTERFCFDSRGNEVLVKEESGGEDSAGKHDERHDQNGHTHDEGSDPQHDHSAETDSAEKKNCHFHAGVEHCVAAEVEEHRGSSCNIQVRDYDVPLRIGTLFVVLITSAVGVFAPILLSKLPFTSVNAVFSTVIKQFGTGIIVATAFVHLYTHSSLMFANQCLGELEYEATASAIVIAGIFLAFLIEFIGYRMTKVREEGVVAVPAVEPKSQSKDGTLRDSEAPAHQESGLLRLGHSHGCSSHPSRPPTKFSVLIMEAGVLFHSILIGLTLVVAGNSFYKTLLVVIIFHQFFEGLALGARIATLSGPIFPSKAVMAGAFAMITPLGMAIGLGVLHIFNGNAKGTLIALGTLDALSAGILVWVGVVDMWARDWVIEGGEMLNASLSKALTGGAAFVTGLVLMGLLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1K0</accession>
    <name>A0A9W9X1K0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788183.1">
        <property type="nucleotide sequence ID" value="XM_056936248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1K0"/>
    <dbReference type="GeneID" id="81626497"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5480753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="196" mass="22106" checksum="2BB0C37C90153441" modified="2023-11-08" version="1">MDADQFITDAGGGIVPIVCHEDGTSCESGLCMRAKVLDGWQSVFKAAGRFRSHSFSFGRNESRFNRQGITTSSTVPSSWQLCIDVVHYSRMKRLPSPRFPAFYQAHHDLLHPSAWRLFYSDLPDSSYPLFGPRNPSAERSAIVLYRAVYTYKAANSQLSKIVTNLAFTYYFRSNDHKSSSRLPERTAIFCISCALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1T8</accession>
    <name>A0A9W9X1T8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione S-transferase kappa</fullName>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_006703</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GST superfamily. Kappa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788239.1">
        <property type="nucleotide sequence ID" value="XM_056936304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1T8"/>
    <dbReference type="GeneID" id="81626553"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000096">
        <property type="entry name" value="Glutathione S-transferase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014440">
        <property type="entry name" value="HCCAis_GSTk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF2">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006386">
        <property type="entry name" value="HCCAis_GSTk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="6">
        <location>
            <begin position="6"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5480809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="218" mass="24260" checksum="4C9021A0FBEC6802" modified="2023-11-08" version="1">MSTPKVTLYFDIISPFAYIAFHVLKHSPTFSKCEVTYVPILLGGLFQLCGNQPPLNIKNKNKWIDNERNRWARRFSVPICATPPPGFPQSTVTVQRALSVVAHKTPEKLPAAIEAIYHSFWVQSNSEIGKVEGFKPVLEGVLGEQVTREVLEAITQAEMKALLPTNTQRAFDAGAFGLPWFECTNAAGEQQCYWGVDNLEDVAGFLGLERGRDPKPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X240</accession>
    <name>A0A9W9X240_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788474.1">
        <property type="nucleotide sequence ID" value="XM_056936539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X240"/>
    <dbReference type="GeneID" id="81626788"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5481044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="346" mass="38100" checksum="422667B211B0D734" modified="2023-11-08" version="1">MPRRKALLIGINYTGSGHQLNGCINDAMNIREYLVRDRGYSPDPRDMVILTDAPENRGTPFYPTGANMLAAFNWLATGNNPGDSLWLSYSGHGSQVRDPDGDRDSGFDDTICPVDFEHNGQITSDTVCAPYAIAQSPSLFHAALARAILLMDGKLHKVIVSPMNPRCRLTILFDCCHSGSAVELPYVFRPDADGKVNMVNNVKEGVSLLREASGLLQGGFSLAKVQDVQGLIGRGSSLLKKFTHPDQPTDENGLADEKFVEDWRNEGKDVWMFSGCADDQTSADTSMQGLATGAMSWAFIRTMRHNPRQTYIEVLQSTRGMLKEKYSQIPQLSVGGRYDLNQPVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3W4</accession>
    <name>A0A9W9X3W4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788751.1">
        <property type="nucleotide sequence ID" value="XM_056935827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X3W4"/>
    <dbReference type="GeneID" id="81626076"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5482779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="81" mass="8411" checksum="45D2080F70EB05F4" modified="2023-11-08" version="1">MSIVSLIETCGGFLPSAARSEVRVIFSDPAVYWLDVNLATKAASAKVSGSEDRAMNCETATSLPPLDRLQGPSSPGPMGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X412</accession>
    <name>A0A9W9X412_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_006285</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788811.1">
        <property type="nucleotide sequence ID" value="XM_056935887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X412"/>
    <dbReference type="GeneID" id="81626136"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF2">
        <property type="entry name" value="FLAVIN CARRIER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040750390" description="ML-like domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="556"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="22"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="622"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="629"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="685"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="727"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5482839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="748" mass="81183" checksum="15C8AD22FF1F1816" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X4N7</accession>
    <name>A0A9W9X4N7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000007">
        <property type="protein sequence ID" value="KAJ5483812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789082.1">
        <property type="nucleotide sequence ID" value="XM_056935614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X4N7"/>
    <dbReference type="GeneID" id="81625863"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5483812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="99" mass="14088" checksum="9260395F1B75EBD6" modified="2023-11-08" version="1">MEDGRYFEPCNRLTDSRITTTTTPYYYYYYSVLLLLRTTPYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYHHLVNLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X549</accession>
    <name>A0A9W9X549_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Very-long-chain 3-oxoacyl-CoA reductase</fullName>
            <ecNumber evidence="12">1.1.1.330</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">3-ketoacyl-CoA reductase</fullName>
            <shortName evidence="12">3-ketoreductase</shortName>
            <shortName evidence="12">KAR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Microsomal beta-keto-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_005864</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="EC" id="1.1.1.330"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.330" evidence="12"/>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789338.1">
        <property type="nucleotide sequence ID" value="XM_056935466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X549"/>
    <dbReference type="GeneID" id="81625715"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045703">
        <property type="term" value="F:ketoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141040">
        <property type="term" value="F:very-long-chain 3-oxoacyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000317">
        <property type="entry name" value="Very-long-chain 3-oxoacyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03107">
        <property type="entry name" value="3_ketoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027533">
        <property type="entry name" value="3_ketoreductase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5484068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="369" mass="39879" checksum="791BD39BF1064808" modified="2023-11-08" version="1">MDLSKYTHCLSQWPDHLAPGLPSIGALLLLGIGGLVVTSKVWSFVRVLLSLFVLPGKPVGLVPFQLLKVSLELSGANGNLKQLRSFGPPGSWAVVTGASDGLGKEFALQLARAKYNVVLVSRTESKLVALAEEITTKFPNVETKILAMDFSRNADEDFQALGALVSDLDVSILINNVGQSHSIPVPFVQTSAKEMTDIITINCHGTLRVTQLVASGMMQRRRGLILTMGSFGGLLPTPLLATYSGSKAFLQQWSTALGYELAPYNIEVELVQAYLITSAMSKIRRASATIPTPRAFVRAVLSKIGRSGGTSSYAYSSSPYWSHGIMAWFLTSVTSPFNKLVVAQNGAMHVAIRKRALRKAEREAQKKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X563</accession>
    <name>A0A9W9X563_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789183.1">
        <property type="nucleotide sequence ID" value="XM_056935311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X563"/>
    <dbReference type="GeneID" id="81625560"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5483913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10149" checksum="57F4115821285717" modified="2023-11-08" version="1">MASNLVPGDDIPVQDNDYVTQRKDEVPVQDDLKEVEDPIDENVADTDEQLAKDDNEAIDTSNIIKDRTRHAKPQTQNGYNEGPSEEEVPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5M8</accession>
    <name>A0A9W9X5M8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_004751</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789547.1">
        <property type="nucleotide sequence ID" value="XM_056934353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5M8"/>
    <dbReference type="GeneID" id="81624602"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="292"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5484763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="46340" checksum="46DC1CF6D53EFB83" modified="2023-11-08" version="1">MSRHPDVDPLRRGHYPPPPEADLSRQGQYPPPPPDDRSRAYPYDQQHHYPYPQQPYPAPPEHDRGYYPPPPPGQYPAPPPPQQQHMAAIHPHAPPDYRLPPPPGAYRPDPYQQPPPQQQPMPYHAAAPRQRTAIACRYCRRRKVSLSTSGFFSRPIRSPMIFARVSEIIAHGMAFLTMVLGSQIRCSGFENSPDGRCTNCQRFNQDCMFTPVSSQAQAFVPAHAAYPHMRPGSNVNGQPPPGTILYGAHGQPLPPNTAVQAPETTLPPPQGMYAAHYGRPAEGAQVPLAQPMADPRQRRGSGTGFDYPEPANLAPVTPASSTPGYQTHTAPSPYYALPHDPRTSPQATYAYEQPRHSTSPHSPYAPITAPPPGQTPPPTSTPGGSQRGGLNVRDILNHGADDSQGRSSTDSDMLNQLNRRGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X638</accession>
    <name>A0A9W9X638_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_005033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789829.1">
        <property type="nucleotide sequence ID" value="XM_056934635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X638"/>
    <dbReference type="GeneID" id="81624884"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="265"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="315"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5485045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="620" mass="67696" checksum="9F1C5028404E02BC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X642</accession>
    <name>A0A9W9X642_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HotDog ACOT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_004975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789771.1">
        <property type="nucleotide sequence ID" value="XM_056934577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X642"/>
    <dbReference type="GeneID" id="81624826"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000032">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000038">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="110"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="307"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5484987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="473" mass="52489" checksum="6F49351942ACF1E9" modified="2023-11-08" version="1" fragment="single">EIYEIRMSSLAGKRFLAARSRSLARAPVPSRTVTAAAGRSPNVNTRDFRTAAVHAASRETWMPMRVKTPWIEALSQRRDSARASEEGTQPAPSVKPDLTPKKMSDSYYSAILPLAQDKWLLDTYLNASGHIRLGSLVMDLDALAGVIAYKHTGEGVSTVTAAVDRITIEHPLMEICDLELSGQVTYATGRSSMEVSVQVCKARPEGQPAQPDDVLITCAFTMVSLDPATKKPVPVAALTVETDEEMALFKKGEANYLAKKSLRKRSLLEKAPDEEESNLIHSMWAKEMSYINPQNPASRPANQIPMADTVLKSAMIMQPQDRNRHNFMIFGGFLLKQTFELAFCCAAAFSHTRPNFLALDPSTFENPVPVGSVLYLRATVAYTEPEEREGGKGKYTKVQVRVDSKVRDVEHGTKKSTGMFNYTFLVERDIHVMPKTYGEFMLWTDARRRAQNSAAIVPHKTSTLRSIQDSVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6D8</accession>
    <name>A0A9W9X6D8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_005130</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789926.1">
        <property type="nucleotide sequence ID" value="XM_056934732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6D8"/>
    <dbReference type="GeneID" id="81624981"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19526">
        <property type="entry name" value="RecA-like_PEX1_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000011">
        <property type="entry name" value="Peroxisome biogenesis protein peroxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001529">
        <property type="entry name" value="Peroxisome biosynthesis protein-like protein (PAS1/Peroxin-1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015342">
        <property type="entry name" value="PEX1-N_C-lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF12">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09262">
        <property type="entry name" value="PEX-1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="551"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="874"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="221"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="706"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1067"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1129"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="706"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="730"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1068"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1139"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5485142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1223" mass="131393" checksum="D146B673988EC536" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6G9</accession>
    <name>A0A9W9X6G9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_005232</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790028.1">
        <property type="nucleotide sequence ID" value="XM_056934834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6G9"/>
    <dbReference type="GeneID" id="81625083"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000167">
        <property type="entry name" value="Uncharacterized mitochondrial carrier C29A3.11c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF9">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="10"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="119"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="233"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5485244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="34596" checksum="00B9B317AD7C2EC9" modified="2023-11-08" version="1">MDESTRNKLFKKYKTQVASAVSTVCATLAVTPLENVKTRMQTHNFKNIFQCARYLWRSEGPRGYVAGALPPLASVTAVRVLNFTSYNYAKEGIADIVKRVTGTSPLAEMEKSSRGPTLLGVMTYSLAGGFAGLVAAPIACPFELAKNVVQTSVLVSNRALASPGAAHDPSLRRKPRIGTIEAAKQIVQRHGFRGLYTGFRLHALRDTVGTAMYFGIYETVKQVAAKEMGSDQSPLGAPAIAGAICSTLPWFATYPLDTRKTRAQSVLLGKTKEIGEASVAVAKSSMYKGISIILVRTGVNNMILLSLFEYIKAQIDELPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6W6</accession>
    <name>A0A9W9X6W6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_005453</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790249.1">
        <property type="nucleotide sequence ID" value="XM_056935055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6W6"/>
    <dbReference type="GeneID" id="81625304"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="36"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5485465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="198" mass="20976" checksum="A006FCD96824749F" modified="2023-11-08" version="1">MTIFESYTNEGPSATSIFCAQGWSAFTVHRTLFPPTSTSTSASTTSSSTTTAAITSSPQFTTTQPSQTSTSSSPTNTPVSPDPAPESKAWIAGAVVGAVAGLAILAGFAWFIYRRRQNKRSDEKQPDERYSSNALLGFHEGSPIEMSADPSHHEMANTLAAQELDGRYKGAAVPRGPTAPGLMSPQELDASSLRSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7A1</accession>
    <name>A0A9W9X7A1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 15">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="3 15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">N7539_005610</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 15"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790406.1">
        <property type="nucleotide sequence ID" value="XM_056935212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X7A1"/>
    <dbReference type="GeneID" id="81625461"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000011">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="18">
        <location>
            <begin position="544"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="99"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ5485622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="966" mass="106432" checksum="72A4396BE84B6580" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCN9</accession>
    <name>A0A9W9XCN9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790997.1">
        <property type="nucleotide sequence ID" value="XM_056933456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCN9"/>
    <dbReference type="GeneID" id="81623705"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034443">
        <property type="entry name" value="PB1A10.08"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="472" mass="52936" checksum="EBCABFCADB4AD3C2" modified="2023-11-08" version="1">MMVPRAFTFSSAPTKKSAGTFDIREHALLLGLNVPDEETFKRLEALPEPSTVTTPMVIPPKRGSRTPVQREVRSRTTSKVTASRRSSSSSSSNDRPLPRSVASMLDATAIPVPRRSWSTRRPKKLPRRHYVEEFNRIMQEGIKSREDYILNECEKFGLCADLEPESPFSVPSSSSDSTPSLEPDMGSPLGSPQPPTPGSQRSMPERRTVRYAPGEDCALDHPLLESALEEREALVFDSDSGPTTPEASQPKRTTSTRSFPSLKSSFKSNLTASLRAIKSAAQSVSTFATPSVQPEDFLTRSLFTITPEMTDDRRPPPMQQPPSPALRRYLNPTPISPAEMCVYHEQPHDHSPPASSCAVSIQMQTYRRSRGRGNRRSNFHVVAPKNRDQYHVFDPEVPSMSRQREPRENCDFLRMVVLEMNMRRSGKLREDIPPRARIMLPPRKSNSYRVSGDYEDGEDNNTVPTRWVGISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCV5</accession>
    <name>A0A9W9XCV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Dihydroxyacetone kinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_003935</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791078.1">
        <property type="nucleotide sequence ID" value="XM_056933537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCV5"/>
    <dbReference type="GeneID" id="81623786"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF14">
        <property type="entry name" value="DIHYDROXYACETONE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="12">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="11">
        <location>
            <begin position="312"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5489045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="517" mass="54801" checksum="E59370D3268FFF94" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDG2</accession>
    <name>A0A9W9XDG2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_004259</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791402.1">
        <property type="nucleotide sequence ID" value="XM_056933861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDG2"/>
    <dbReference type="GeneID" id="81624110"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
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            <begin position="591"/>
            <end position="685"/>
        </location>
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            <end position="552"/>
        </location>
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            <end position="780"/>
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            <end position="37"/>
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            <begin position="43"/>
            <end position="56"/>
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            <end position="125"/>
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            <end position="724"/>
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        <location>
            <begin position="746"/>
            <end position="763"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5489369.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="859" mass="92822" checksum="9421C7802910F102" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDV0</accession>
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        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
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        </source>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
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        <text evidence="4">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        </location>
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    </feature>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
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            <dbReference type="EMBL" id="KAJ5489560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="719" mass="80743" checksum="23F16150369452FD" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDX2</accession>
    <name>A0A9W9XDX2_9EURO</name>
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        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">N7539_004436</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056934038.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81624287"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF159">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14230)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="54"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5489546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="492" mass="54556" checksum="4DF1B46369AFC5ED" modified="2023-11-08" version="1">MDKHNFIGDIGEFQLDEVSTASQSQEMIISEHGMKTLDSMDKNNPRNWSRARKTLLFVSLMSSSLLADGGMVWGGTLVTPQAIEWGISVTHSATSMNYGILLQGFGGMFAVPLIETYGRYPVWIWPQAITMFMVLGATLSKDYTTFTVFRTLQGLFGTVPQVIGLPIIHDMYSPEEWPRMINIWGTAFMVGPYLAPALAGYIGDASTWVISFAVLTAIYALSTLMVLVFGAETYYTPGKAPIPRFASYIGNHNTGLPKRATILHWSKVMIAYVFKFPLLMTGIATLITFTWPIGIATTIDVFLHSPPYNFNTIQASSMRFAGVVGALGALTINKPGWLVGFIFNEWIYKRHNAKWRTEYRLHGVWFPLSSMVCGLLTYGLTMHFGKHWIGIVFGWIMVTLGMVASTVAVTAYALEKYPDQATVVSAILNMWRTSGGFAVGYFQTAWIARNGLGLVFGIQAIVVGVAVVLCIVPVFIVERKYPRRGCIETRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEF1</accession>
    <name>A0A9W9XEF1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sphingolipid C4-hydroxylase sur2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_002316</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791878.1">
        <property type="nucleotide sequence ID" value="XM_056931919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEF1"/>
    <dbReference type="GeneID" id="81622168"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="205"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5490749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="422" mass="47780" checksum="771CFB446A6F99EA" modified="2023-11-08" version="1">MAANASAVFDLPPLPTYTLSAREPLLPPIPDNVLALILPIIAYWGLSMVYHFIDVNGYFEQYRLHTPAEVLKRNKVTRWEVVRDVVLQQIIQTIAGYAMSYFDAVEVVGREDYDVAVWATRLRLLQTVIPSTLGFVGVDALGLSESLYHSGHSVLAGVLAGGSYRNLVQSMVLDNGVEVVAPAFASWELSVASIIYWYLIPGLQFALAVSILDTWQYFLHRAMHLNRWLYVTFHSRHHRLYVPYAFGALYNHPVEGFLLDTLGTGVGYLVSGMTSRQSMMFFTFSTIKTVDDHCGYAFPWDPLQHVTSNNAAYHDIHHQSWGIKTNFSQPFFTFWDRLLNTQWKGETKLRYERARENAQKQLEADIVQAQNETSISAPSLERERDRVVVSLDGPATRTRFRRKTVDSLKGPSHAVPGSVLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFA2</accession>
    <name>A0A9W9XFA2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_002748</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792310.1">
        <property type="nucleotide sequence ID" value="XM_056932351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFA2"/>
    <dbReference type="GeneID" id="81622600"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000018">
        <property type="entry name" value="SCP-like extracellular protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040816879" description="SCP domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="154"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5491181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="321" mass="33491" checksum="A33AE83F75E9B52C" modified="2023-11-08" version="1">MRFTLLLAALAAGCVNAVEKDVYVTDWTTVTVTETVTAPAVTETVLPPQVQLQHVAPTTTVPVVESVVAPSSTSAVEKPVTSSAPAPVETQAAKEPSPAPVQEPAVVTTQAPAPVETAVVSSSAWSTAWTSTLSVAPAATTQAAAPASAPAGNSYQSTVLYNHNVHRSNHSASSLDWSADLESSAKVLASRCVYEHDVSIPGGSIAAGSYGQNIGYGVEASDVGVMITNLMYNDEINYFPQPYGSPNPDMTLFDKWGHFSQIVWKGTTHVGCATVTCPNLGNVDSSMALPFTVCNYYPAGNVGTEYGDNVLAPLRQPSYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFA8</accession>
    <name>A0A9W9XFA8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="14">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_002781</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.102"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:22642"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="14"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792343.1">
        <property type="nucleotide sequence ID" value="XM_056932384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFA8"/>
    <dbReference type="GeneID" id="81622633"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000456">
        <property type="entry name" value="3-ketodihydrosphingosine reductase tsc10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5491214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="374" mass="40702" checksum="9D6E4B5064500065" modified="2023-11-08" version="1">MSLSTRLSTLHDIPPSLLGVSLLACVAIAYTITKMLGFGRKNEFPVEGRTILITGGSDGTGRALAIQLAAKGAHVAIVARTVSKLQSTVQELQTEALHPVQQRFHYISADLIDNNECERVMAEVTEWNDGSPPDIVFCCAGFCLPGFFADVPIATQRQQMDTVYWTAANMAHATLRKWLTPIQPSNQTKTPRRHLIFCASVVAFAPIAGYGPYSAAKAALRSLSDTLSQEVEMYNGAYSQRHREVAPAADVKIHTLFPMGILTPGYDNEQQLKPALTKKLEESDRPQTPEEVARITIAALERGEYLITTMLMGNILKGFSLGLSPRNGLIGDTLIGWLSNLVALQVIPDLRKKAFNWGQSQGLPKPVSQASASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFC0</accession>
    <name>A0A9W9XFC0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Capsule polysaccharide biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792261.1">
        <property type="nucleotide sequence ID" value="XM_056932302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFC0"/>
    <dbReference type="GeneID" id="81622551"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5491132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="37046" checksum="B4A9FC5FBE277184" modified="2023-11-08" version="1">MLGSHLTWTRALALLLIITNIKNLPLIWHVRLLYHFLIQLRWKPSDPYFPKGHALLDAQGKPTHPVFVSYKITSRTPLLETDYNLHKSNSTYFSDLDVSRTALVTRLYSPGVGLVSKELDQEFLEASKKEGKRAPKRKPIMIVLGSVYCSFKREIKPFERYEVHSKVISWDKKWLYILSSFMRPASRRGGERTLLATALSKYVVKKGRLTVAPARILCLSGFLPAMPIGDSTTQANDESPAENSAVDTPASNEGITAAEGIDGSLAREILKLTDETIPGREALEDQKAANAKSWDSDEWTGKRIEQERLRGLGVVDGYVNLDAQLHAEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFN6</accession>
    <name>A0A9W9XFN6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_002982</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792544.1">
        <property type="nucleotide sequence ID" value="XM_056932585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFN6"/>
    <dbReference type="GeneID" id="81622834"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF125">
        <property type="entry name" value="GTPASE ACTIVATOR (BEM2), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04450)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="378"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="567"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="567"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5491415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="650" mass="71898" checksum="E804B97A2C6E5989" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFQ2</accession>
    <name>A0A9W9XFQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002926</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792488.1">
        <property type="nucleotide sequence ID" value="XM_056932529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFQ2"/>
    <dbReference type="GeneID" id="81622778"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF39">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="35"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5491359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="111" mass="12436" checksum="C0E46ED7B7083280" modified="2023-11-08" version="1">MNPDGDDERSSTTPTAGPKSASAAEKDKPRLTDQEKKNNHIASEQKRRAAIREGFDRLTELVPGLEGQGRSESIVLQKTVEFIHMKLREREDLISEIEHKGGRVDDSLRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG11</accession>
    <name>A0A9W9XG11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003044</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792606.1">
        <property type="nucleotide sequence ID" value="XM_056932647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG11"/>
    <dbReference type="GeneID" id="81622896"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000099">
        <property type="entry name" value="Alpha,alpha-trehalose phosphate synthase subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF15">
        <property type="entry name" value="TREHALOSE SYNTHASE COMPLEX REGULATORY SUBUNIT TPS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040953793" evidence="7">
        <location>
            <begin position="17"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5491477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="914" mass="102325" checksum="0B34E980CA785773" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG79</accession>
    <name>A0A9W9XG79_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792789.1">
        <property type="nucleotide sequence ID" value="XM_056932830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG79"/>
    <dbReference type="GeneID" id="81623079"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="95"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="566" mass="64864" checksum="6077F76AEA04386D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG84</accession>
    <name>A0A9W9XG84_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792725.1">
        <property type="nucleotide sequence ID" value="XM_056932766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG84"/>
    <dbReference type="GeneID" id="81623015"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="73" mass="7868" checksum="8FB2300E02E1DAD3" modified="2023-11-08" version="1">MILPARGGLTARVAISLVPTSLYIHGVYRIHEIDIIHKADMLMARLAIILANRAIGVGTLLSSGVALWMTKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGI4</accession>
    <name>A0A9W9XGI4_9EURO</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_002749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792311.1">
        <property type="nucleotide sequence ID" value="XM_056932352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGI4"/>
    <dbReference type="GeneID" id="81622601"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5491182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="110" mass="12387" checksum="1FAFF758A3A59350" modified="2023-11-08" version="1">MFRARSWRGRCLECVAERVQQTEINNKKDGEEAHHRLLRLITDFTDSATLQFNEVKTFLRPPIDSGSLHLDLALSIGLASSSCSPSSIRAIRVCRICCRGLENPDRDAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGJ8</accession>
    <name>A0A9W9XGJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792522.1">
        <property type="nucleotide sequence ID" value="XM_056932563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGJ8"/>
    <dbReference type="GeneID" id="81622812"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="109" mass="12796" checksum="89BDAFDDC826F875" modified="2023-11-08" version="1">MTQLRLIRSRSKQAASIPSEDPWRNDNPFGPPPMQRSPSHHMRRLRETLAKWSPSALAEKEILRKQNQYKIPLTRRNVDHLVTVQQCDEAIRPTRTPEIQVVEWLQHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGM8</accession>
    <name>A0A9W9XGM8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056932708.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81622957"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF131">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041011526" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="546"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5491538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="573" mass="64045" checksum="92550E808F2EADCA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGY4</accession>
    <name>A0A9W9XGY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_001583</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793217.1">
        <property type="nucleotide sequence ID" value="XM_056931186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGY4"/>
    <dbReference type="GeneID" id="81621435"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000027">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="175"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5492837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="305" mass="34662" checksum="A7F5F373B477BDE5" modified="2023-11-08" version="1">MASSGPRLSTLITWLLYFVPVYIFIVDPLVRSWAPEGTTRISWLTGTTAGPNADDGDVSEEFTPSTLHLTDDSFISPEDGVPAHCPGEADGYRVHLLSRVPLVLYVEKFVSDQEADHLIKVSLDKYSPSIIYDGVSERVDPSKRLSDRALLDRDDTVRCLEERARAFQGWRPHLYIERMWAQRYNASGHYRHHYDWTGSLARGGDRLSTFMVYLGADCEGGGTHFPRLARPEGQQWCRFLDCEEEVGITFRPLKGNAIFWENLGPDGLGYPETWHAAYPVKSGTKVGLNIWSWYQPPLRKRRGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHV3</accession>
    <name>A0A9W9XHV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_002048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793682.1">
        <property type="nucleotide sequence ID" value="XM_056931651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHV3"/>
    <dbReference type="GeneID" id="81621900"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF96">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5493302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31354" checksum="1C40E516DF109498" modified="2023-11-08" version="1">MSETIEAGFHLADSNGYMLGRGHSAACRLNLQFFLWKESLRFNIHPSIPISSNPVIADLGTGTGIWLINLSRELPTATLDGYDVDLSNSPPREWLPERLHLHHWDLFTPVPDHMVGKYDVVHLRLLILVVQNSDPTPVIQNVARLLKPGGYVQWDDLNYPGTHIRRANPSMKAPAFDRLRQFVYSNGRHDWVLNLPELLAQNGFTDTRLEHFDDSIELSTANGEQHLATMDEFVLSLEKKNMMEDAQNIRQLLKDVAVEAVHGVALSMPRVVAVGRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI16</accession>
    <name>A0A9W9XI16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793763.1">
        <property type="nucleotide sequence ID" value="XM_056931732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XI16"/>
    <dbReference type="GeneID" id="81621981"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="254" mass="27861" checksum="2192FF848960DA83" modified="2023-11-08" version="1">MSTLTRAFTKRSKRPEVSAPMPYRKEGHMRFNSGSIKRSNISGPVQLISTTNMLAYDAPDILPSTSSSSSSLRSGDDYDTGSPQSYSSSITTPDVSPSDPFPVAANAGSYFPKRSATVTSQPRSSNTSFSSNEAPLVPQRALSHTKRSHQELARQRSQHRMSPPPLAAPRSNPTIRASQDVFFADNHPFSKELAQVNEVAEEFGATHIMDEEELLLQRKGLKKFSVEDYLSEIESVYGSVFDDRVGPASVSAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIG3</accession>
    <name>A0A9W9XIG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase-like protein tpcF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_001710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793344.1">
        <property type="nucleotide sequence ID" value="XM_056931313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIG3"/>
    <dbReference type="GeneID" id="81621562"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10291">
        <property type="entry name" value="GST_C_YfcG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="117"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5492964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="291" mass="32898" checksum="EE62C758D59ADA4D" modified="2023-11-08" version="1">MSQPNITLYTTQTPNGIKISIALEELGLPYKVEKIDISKNTQKEEYVSDLMKWLTTAAYIKATKMRWFLEINPNGRIPALTDTFTDGQTIRLFESGSILQYLVERYDPDHKISYPAGTREYYETNNWLFFQNAGVGPMQGQANHFGRYAPERIEYGVNRYVNETRRLYRVLDDHLAKSKSGYLVGDRATIADISHWGWVAAAGWAGVDIEEFPNLKAWEERMAARPALEKGRHVPSPHTIKELLKDKAAVEKRCCASSGVGPSGYEGGREEQNLNPDSVSMLVGKLMISEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XII3</accession>
    <name>A0A9W9XII3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793540.1">
        <property type="nucleotide sequence ID" value="XM_056931509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XII3"/>
    <dbReference type="GeneID" id="81621758"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="250" mass="25625" checksum="E35A9B39CD8F8121" modified="2023-11-08" version="1">MSREASSELSASEVLNEVAPTSTAPKGNESSQPVHNVLNTCQTDSESVSGEGAKTNGAIEHPEAPKPVESMQTTDASASDDPLGASVAASEPAGAETTEVKPDTASSIAEPTKPAQGDSLETKPAAEPPKPAAQPSKPVDEVSTAAAQSPKTGEKRDLEVTDTPLAGGESSTKVNSGVEQGEEHDSKKQKTEHKTNNGTNGASNITGATEAPDKAKDSSSSKKEKVKEAVKKVLPTDGPGTRTRSRTKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLP7</accession>
    <name>A0A9W9XLP7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_000309</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794206.1">
        <property type="nucleotide sequence ID" value="XM_056929913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLP7"/>
    <dbReference type="GeneID" id="81620162"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000364">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF79">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="47"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5495193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="499" mass="55115" checksum="9EAD49C756BDCD16" modified="2023-11-08" version="1">MMAEKDTTIMHLENQPGPGISTEDAEFLSNFSDEARKKVLRKVDLRLVPMLVLLYLVAYIDKTNIGNAKIEGLLSSLHMDGIQYNIALSIFFIPYVLAEVPSNIILNRLKRPSRYLGFLILCWGVVMLCTGFVQNFAGLVVIRVLLGLFEAGFLPGAVLVISKWYLPNETQTRIAILYTSAASGGAFSGLLAFAIAKMNGVAGYEGWRWIFIIEGIATCIIAAACYMLLLDSPSLSAAWLTPDEIRFLEVRQMANNNHGSHGGSLDKSIILSVICDWKMYLLILINWSNAVPNYALKFSMPAIIKSMGYKAASAQLLTIPPYMVGAFSAYGFSVFADRSSWRMPFILAPQLSLIVAFSILFSKAADIKNNIAVCYFGVCLACFGMYPILPGVNAWNVGNIPNPQKRAVAIGYLICFGNAGGIIGSYIYQSREAPRYPTGYGTSLAFAASGIVACLTLEFCLWRANKTKERMSASEVEERYTEDQLREMEEKSPLFKYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMC6</accession>
    <name>A0A9W9XMC6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_000669</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794566.1">
        <property type="nucleotide sequence ID" value="XM_056930273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMC6"/>
    <dbReference type="GeneID" id="81620522"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000118">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5495553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="482" mass="53692" checksum="1504EEFE96594EF4" modified="2023-11-08" version="1">MEYDFGSARTYHTFAVNGTAIPDVDFDIGESYAGLLPVSDIHGDERQLYFWYFPTDNLDATDAITIWLNGGPGCSSLEGLLQENGPFTWQYGTFKPVANPYSWHHLTDMYWVDQPIGTGFSVGNANVTTQPDVAEQFLGFLKNFIELFGFQGCKIYLTGESYAGMFVPYIAHAMLEAKDTQLYNLDGIMLYDPTLAGRAVERELFAYSTYEAWSKLFAFNDTFSSYLRDRAASCGYTDYVNKYFLFPPLGKMPTVRSDCDLYMEIGNNAFNTNPCWDPYHLATTCPSLWDVLGAPGAFDYLPTGASIYFDRPEVKKAINAPQSSNWKECTDLSVFVNGTDQTAAAGLWSSQTVLPGVIERVTRALIGQGDMDYTILPNGTLFAIQNMTWGGAQGFQRAPDGEFYVPADTKQSAGSGIMGKTRTERGLTFVEVELCGHMANGFLWLEIVPQYQPSASFRHLEYLLGRVDSLGSREPFTVEIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMD4</accession>
    <name>A0A9W9XMD4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_000684</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794581.1">
        <property type="nucleotide sequence ID" value="XM_056930288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMD4"/>
    <dbReference type="GeneID" id="81620537"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="6">
        <location>
            <begin position="11"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5495568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="423" mass="47089" checksum="B5CF90AB4C27213D" modified="2023-11-08" version="1">MSPTPQQLLAISITERVCSAVSLLGAFVIVTTFMSSWSFRKPINRLVFYASWGNIMANLATLISQSGIHSGVDNPLCQFQAFLIQWFMPADALWTFAMACNVYLTFFHKYNSDQLRQLEWKYLAGCYGIPFIPAFVYFFISTSSLGRVYGSAVLWCWVSRPWDFLRIATFYGPVWMVIFVTFTIYLRAGSVIYQKRRQLEALENADCSDAQPATDSPPISSSLCGIQVTHEVALFEPERPCSALSNHPSSAASSIHGLDSPVFTPYSVSVESGTVDPIIMYLNSMPEQTPHYGPGSRSRQNSTVSHSDASIALKNARCTGADSSPTRRTATADIGSAAWIYTKYAMLFFIALLVTWVPSTANRVYSLARPDDFSFALNYASSFVLPLQGFWNSLIYVSISWPAFKALWTKLRVSLSGLKRDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMP5</accession>
    <name>A0A9W9XMP5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycerol uptake protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_000962</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794859.1">
        <property type="nucleotide sequence ID" value="XM_056930566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMP5"/>
    <dbReference type="GeneID" id="81620815"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="604"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5495846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="637" mass="72000" checksum="1BBC5C8C425F2AEE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMY2</accession>
    <name>A0A9W9XMY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_001043</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794940.1">
        <property type="nucleotide sequence ID" value="XM_056930647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMY2"/>
    <dbReference type="GeneID" id="81620896"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="7 11" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="6" id="KW-0964">Secreted</keyword>
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            <end position="110"/>
        </location>
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            <begin position="284"/>
            <end position="298"/>
        </location>
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        </location>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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        </source>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="557" mass="59967" checksum="518A4A7A19499417" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN45</accession>
    <name>A0A9W9XN45_9EURO</name>
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            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
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    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
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            <authorList>
                <person name="Petersen C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <end position="947"/>
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            <end position="1084"/>
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        <location>
            <begin position="1066"/>
            <end position="1075"/>
        </location>
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        <source>
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        </source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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            <dbReference type="SMART" id="SM00322"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1084" mass="120022" checksum="0DE912191BEC7AA2" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN81</accession>
    <name>A0A9W9XN81_9EURO</name>
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        <recommendedName>
            <fullName evidence="1">Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich domain-containing protein</fullName>
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    </protein>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAPWDQ010000001">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="1">
        <location>
            <begin position="151"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5496033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="206" mass="22798" checksum="183037C60EC9A98B" modified="2023-11-08" version="1">MATSYPRPDFERKSLNWVSPNGVWDFLFDDGNEGLANEWPKKGIPPNTAHNQSKLEIEVPYAFQPAASGGVRNRVARRPRSDVIAVTGRSPQGICAVEIEVLLIGSSVVTKEAELPKERDLVAFDLDMKLDDIAGFQTTAPYDQEGVWLNGIALWAPEHPILYDLVLRLRNGSGNQVDEVHTTVGMHSLSWQSGDGTFRLNGKPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN95</accession>
    <name>A0A9W9XN95_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="9 10">
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    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795141.1">
        <property type="nucleotide sequence ID" value="XM_056930848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN95"/>
    <dbReference type="GeneID" id="81621097"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF13">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN MOC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="481"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="293"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="440"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="521"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5496128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="907" mass="96849" checksum="958FFFDEE3AC4895" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XNB4</accession>
    <name>A0A9W9XNB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_000851</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794748.1">
        <property type="nucleotide sequence ID" value="XM_056930455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XNB4"/>
    <dbReference type="GeneID" id="81620704"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000055">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000125">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF23">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE USP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="404"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="726"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="648"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="612"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="672"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5495735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1091" mass="122586" checksum="558205044B1138D3" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ11</accession>
    <name>A0A9X0BJ11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_009555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785645.1">
        <property type="nucleotide sequence ID" value="XM_056939150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJ11"/>
    <dbReference type="GeneID" id="81629400"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008701">
        <property type="entry name" value="NPP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05630">
        <property type="entry name" value="NPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5466599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="247" mass="27390" checksum="51F4D062518C0952" modified="2023-11-08" version="1">MWFFGQAMSQPPCYPTWAFGGSPTTADIYDSAHQTPAAPQCEYPNVGCHCRNPGVGIGNRGPAFPVYYTYQRCSDTEVRVAYNLFYEKDGATFGAIQTGHNYDWERVIVIHSRDSSNMWSPSRALLSAHSGYHNLAWADIQNTLTTDEINAGDAKTPNGVRNNDHPKVYVSWSKHANFDTRNTGWNDPASQSLEDAFRSQDWWYFVDPQYYIRADLSTDAGKALAAANWGDATSNPPSVHAGLCSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJC0</accession>
    <name>A0A9X0BJC0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NLP effector protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_008856</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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                <person name="Nielsen M.R."/>
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        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Penicillium diatomitis</name>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="9">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.</text>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.650:FF:000004">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000065">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
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    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
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    <dbReference type="InterPro" id="IPR049540">
        <property type="entry name" value="Spt6-like_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028083">
        <property type="entry name" value="Spt6_acidic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14632">
        <property type="entry name" value="SPT6_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21710">
        <property type="entry name" value="Spt6_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036947">
        <property type="entry name" value="Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="SH2" evidence="12">
        <location>
            <begin position="1224"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1181"/>
            <end position="1213"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
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            <end position="151"/>
        </location>
    </feature>
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        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1187"/>
            <end position="1213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5469494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1415" mass="163138" checksum="46ECA5DA075A7872" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJV5</accession>
    <name>A0A9X0BJV5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_009351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786323.1">
        <property type="nucleotide sequence ID" value="XM_056938946.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81629196"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5469733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26270" checksum="CE8AF9C0FEA06B95" modified="2023-11-08" version="1">MSGRESQRTTSQPPEPTVAGLFVLPVEVRYRIFKLVLAVPDSLYLFQDRGSPLESFMPYKPHAWLALLYTCRRLSYEARSVLYGANRFTLEEVEIANYRSNILRSFIKGIGSVNAGFLSNLRISFPATERVHGQEGEIRLREDDLQNLQLLQNKCTGLGTLEALIYGQSCQYLITEDQDNPQFAYDLLAKIDSEFRKIASLGTIIVRYCSGSPDSSIRDFLESMGWVVLVGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BLR3</accession>
    <name>A0A9X0BLR3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786572.1">
        <property type="nucleotide sequence ID" value="XM_056938190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BLR3"/>
    <dbReference type="GeneID" id="81628440"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5472026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="176" mass="20326" checksum="FA10CEEE283DB1E8" modified="2023-11-08" version="1">MEEETQSVASRDLILWLWVSWFFRLPTQFNLSTSIAISQSDGCIDNLGLPIPEDVIVLINRRREKAIKKLIDLIGDTRKQYLLGALGCRFECRSIMYGALTIQSKDLLLPYRECPFPNVNYRSLLQRMTKFRTPEWYDSPSRYIDNHSCPGSFFASIFGALEGFLEGLELDQFKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BN10</accession>
    <name>A0A9X0BN10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_008246</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786938.1">
        <property type="nucleotide sequence ID" value="XM_056937846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BN10"/>
    <dbReference type="GeneID" id="81628096"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CCAATSUBUNTB"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="257"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5475180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="360" mass="38184" checksum="8104CC68A8C580FB" modified="2023-11-08" version="1">MEYPPQYPQAHGQHPHAPPHMPGPYQSGPPQQGAPVGSMASPSNAQPPMQPQHPSHQTSPIVPTQQHYQQAPGGPGAVHQQMTFPQGYGVSAAMGQPYGISPGQAAAMATAAASGQLYPFPQHDAMGQQMAPGTRGSPRMGGMPMKTDRNPRSPPQMSGPMPPMGQQVQMQSQQMPPGRRMSHIGSPNVAPAQPVMSHVGRGSIGQAMAGPSQAALQTQASPEMVPGGNQEESPLYVNAKQFHRILKRRVARQKLEEQLRLTSKGRKPYLHESRHNHAMRRPRGPGGRFLTADEVAAMEKKAAEGDGEGSADLGKENGAAGQKRKSSEVHDDGGSAKKTKSHVTAEGSEQESADPSDEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BN13</accession>
    <name>A0A9X0BN13_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">N7539_008175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAJ5475109.1"/>
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    <dbReference type="GeneID" id="81628025"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="623" mass="65021" checksum="61AC071B697C1944" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNP8</accession>
    <name>A0A9X0BNP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">N7539_007890</name>
    </gene>
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        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
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            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
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            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="325" mass="36776" checksum="DBAC85121E017E2F" modified="2023-11-08" version="1">MSSRNSSQLPGVDDSQVGISDLEGPQYPWSTHSHHVPREPDNTTTLASQSSLVHTSNISPSADYLTNDEASHADEPVPLSLNEQQNNLEPTTAQHTSAPPEFTPSCKFSGQCSLVPSPDGVKYYRKVVSHIFGRNKSSTQKIPDSVWIYYCRKHYQRSLYRADKWPFTQCELLLQTLARMESWGGVQSFELRLRAREVRRVDGETPTPAPIGSGRRHPRAAPAPVPGWLQQELGDHKSFDEIRRLVQRIHGYLRGVQQAEQVQRSSRNTASQTQRVNKESRVTAYRERFQSAVRFPDVELIPTFFVEESTESQATETRDVSEEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNQ2</accession>
    <name>A0A9X0BNQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787220.1">
        <property type="nucleotide sequence ID" value="XM_056937355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNQ2"/>
    <dbReference type="GeneID" id="81627604"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="45"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5475467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="329" mass="36327" checksum="33500BC87AE1884F" modified="2023-11-08" version="1">MSIPSDPKLDGFEIIQANYKHIGDHAIRADILIPRTEHSGPRPLIVRVHGGGLMMGDSLYMDWWPHWVSDLALQKNAVIISPNYRLMPEATSFDIFADMADFWTWLQSSPLREILAAHTPPTAIDLNRIFVTGESAGGLLSVHLALTYPDQIRAASAAYPAVALNAETFTQPRANPPFGLDIPETLVQGTLDSIALGTAVSSLTSQNRVDFMLGAIQHGYLSRLYERGAETIPPSVLYPILKVEQSDLKVPRGGLVVLHGRHDSVVPLRDSERFVARAQQVLAGRLNEQGRGRVTLVVRDGEHGYDAPARFEEDWLQEAMQDAVSAWLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNR0</accession>
    <name>A0A9X0BNR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_007152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787552.1">
        <property type="nucleotide sequence ID" value="XM_056936753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNR0"/>
    <dbReference type="GeneID" id="81627002"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5477008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="165" mass="19336" checksum="BFD53D06F9A4A952" modified="2023-11-08" version="1">MSGFFAEVYLVNNMIIRKASRSGSEEDFLLHDHPRIAECICRGRMDFIDITIRMIWYCGELFVDDDFDIRLSDFDSSHYPGYENATHFLPTYCKLPDTFEDIVHGRRDPQLVVARFSREQAADPKVQQRYENHAFHEVYRLFRGDMRLGLWKGGGGLLPQNRHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNS2</accession>
    <name>A0A9X0BNS2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787773.1">
        <property type="nucleotide sequence ID" value="XM_056936974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNS2"/>
    <dbReference type="GeneID" id="81627223"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021102">
        <property type="entry name" value="PNGase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056948">
        <property type="entry name" value="PNGaseA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31104">
        <property type="entry name" value="PEPTIDE-N4-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25156">
        <property type="entry name" value="PNGase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12222">
        <property type="entry name" value="PNGaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5477229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="511" mass="55021" checksum="7BC518EDB6445CAF" modified="2023-11-08" version="1">MTVTSSGRQYDRLALMYLGDAEVFRTSTAEPTSTGIAWTYIKEMSQYNALWQAPQKLLFDLGNIINDVYTGPFNVRLTAHFSKTEKAPSADIILPISARRSAANSASAFTVPSDNTTVTYGIPNTVKQAVVAISACGQSQEEFWWSNVFTEDTHDFDSTVGELYGYSPFREIQLYIDGILAGVVWPFPIIFTGGVAPGFWRPIVGIDAFDLRQSEIDISPFLPMLQDGRQHSFEIRVAGVAITAGGTAVLTQSVGSYWVVTGNIFLFNGQQARSQSKDKSRGSVPHVVTPAPIFSVKRHLAQNKTGGNDTLSYSVTAERTLTVSSPDYTWSQRLSFSNFGYLNQQGYSQVNDQKTSGVNRITKLGHGHQVNSTSFDYPLLVNATYGITPNSLSIDAWMTRGLDIKSSGGPGISTYTFVSGPSELHTSQSGSAHYKSVTGSGSFSYGSTSDEFSSISAGVAYSRRVEAVNGTVVSDSEPGSVRSAAPGGIQKGLGRGNIRSMLGRGPGNPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNS9</accession>
    <name>A0A9X0BNS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-related protein 2/3 complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_007388</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytoskeleton</location>
            <location evidence="7">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787788.1">
        <property type="nucleotide sequence ID" value="XM_056936989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNS9"/>
    <dbReference type="GeneID" id="81627238"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000220">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038093">
        <property type="entry name" value="ARP2/3_su1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5477244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="363" mass="39917" checksum="D23D7F3D95B97610" modified="2023-11-08" version="1">MAVPQVHHLFHAPIADHSFSSDRQTLAVARDNNVELYQSSGNKFTLSDELKGHDKTVTSVDIAPNSGRIVTCSQDRNAYVWEKTASGWKPTLVLLRINRAATFVRWSPSEQKFAVGSGARVIAVCYFEEENDWWISKHLKKPIRSTITTLAWHPNSVLLAAGSTDSHARVFSSFIKGIDQRPEPSAWGERLPFNTICGEFLNDTAGWIHGVSFSPSGNALAFTGHDSSVTVVYPSAPEQPPRAMLNISTRLLPLNSLIWNGENEIIAAGHDCEPFRFQGDENGWQLTGSMEKQGGAGAAGAREESALNMFRQMDLKGQSSVDTKLKSTHQNTVNTVRVFEESNGQVRSFSTSGVDGRVVVWST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNX5</accession>
    <name>A0A9X0BNX5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Erythromycin esterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_007181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787581.1">
        <property type="nucleotide sequence ID" value="XM_056936782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNX5"/>
    <dbReference type="GeneID" id="81627031"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14728">
        <property type="entry name" value="Ere-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1660.10">
        <property type="entry name" value="EreA-like (biosynthetic domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1870.10">
        <property type="entry name" value="EreA-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007815">
        <property type="entry name" value="Emycin_Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052036">
        <property type="entry name" value="Hydrolase/PRTase-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014622">
        <property type="entry name" value="UCP036794_erythomycin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31299">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31299:SF0">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05139">
        <property type="entry name" value="Erythro_esteras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036794">
        <property type="entry name" value="UCP_erythr_ester"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159501">
        <property type="entry name" value="EreA/ChaN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5477037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="51864" checksum="2755325DEFDE6284" modified="2023-11-08" version="1">MAQFQELFNQAVKPLPEIDNPSFASYFDGFSDKQMMLLGDGSHGTSEFYRARAEITKRMIKEHGFTIVAIEADWPDVEAIDRYVRLRTGPKAQIGGKAKGFEPFKRFPTWMWRNREMQEFVEWMRDWNSTQPPEKRAGLYGLDLYSMGSSIRAVIEYLDRVDPHAGKAARKRYGCLDRWIEDPSAYGLAAIRGLEDCEPQVLRILQDLLANRLKYLETDPYDGEEFHSSSQNAFVARDAEQYYKAMYWSSATSWTLRDTHMVDTLQRILQHRPPPENKAIVWAHNSHVGDARFTSMGTRRNEVNIGQLCRERFGRENVAILGCGTHTGTVAAAHEWDDDMEVMTVNPSRDDSWEIIAHNTGIPSFVLDLRREHIDPNLRAAIAREHRLQRFIGVIYRPETEKLSHYSKAQIHKQFDGYIWFDRTKAVQPLEVIQPVTPLGKEETYPFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BP61</accession>
    <name>A0A9X0BP61_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788017.1">
        <property type="nucleotide sequence ID" value="XM_056937218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BP61"/>
    <dbReference type="GeneID" id="81627467"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5477473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="418" mass="45506" checksum="646D94B68C82A31D" modified="2023-11-08" version="1">MPSSVVGLQLSFSVSLLRPLILCMLAPVVAGIETDPSKRSTPDQPSLDKALLGIQIGSIAGAYLVFVAVLLGLLLLVGRRLRRTVQSSNYSLQMHLLQPVKQNLNLDPDPRFPMSHHPPGQAAAGAQQASWGNFPSANRPSQNSSTHGSVVTIDESVVASDRQRAQDQMAMLYAAVLEHDAQKSIRDSDSPAHSPDSQYTNPFTDRHASQQPLGDSYREPLKSPKPSGSRLTKLFSSKSSSQPDGGKLRSPRFPLRKLGISSPLASPDMHVSHSYGLDQVPLSPRLYTPGPPPAAPRAAPPVAHIMPPPNRTRAAPAPLNLSTPTSQTPSSLPFREAYPLQSAPPTKTTILERPTKTRNGPMTGMPTPYSAYMPYTPVTPFTPGRMVTRRERRREERENGLRVLNEDDLVKDDQDVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BPD2</accession>
    <name>A0A9X0BPD2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_007480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787880.1">
        <property type="nucleotide sequence ID" value="XM_056937081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BPD2"/>
    <dbReference type="GeneID" id="81627330"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5477336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="345" mass="37601" checksum="D3EF071ED1A7A141" modified="2023-11-08" version="1">MPTVLLPSSAAAFAPRASPNVVLTRKVAPWLTATLKRVNRVKRPLNNVTQHTRCLTETLSSTNAIWTLCSMMFTKAPESELRKDENPLVEGLFNYQMIHIEAYVVHVDMVSRNEVAFKLTPETIESLVDFHKDIYSKDAAANTWDWSGKQVQLKKLQEEFVQAANKFVYRTDAEALEGLEDDGAGELLFGRSEDAKAAISALFVPLLPPPPRVVDVVRPVPLLPSSTGPETWWSTPMPPAAPLEWKLVPSSPSPACTEESNPNLWASIAFTEAQLPSPTPSYSMPLTTAPYSTYDMSMAPTSAGVASLPLPSMLVQPCSTAASMAGFGGFGGWGEFAPLPYGMIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BPJ7</accession>
    <name>A0A9X0BPJ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Patatin-like phospholipase domain-containing protein</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_007675</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lipid hydrolase.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788075.1">
        <property type="nucleotide sequence ID" value="XM_056937276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BPJ7"/>
    <dbReference type="GeneID" id="81627525"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07232">
        <property type="entry name" value="Pat_PLPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF66">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE PTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7 9 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="12">
        <location>
            <begin position="276"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="9">
        <location>
            <begin position="307"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5477531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="707" mass="80821" checksum="F61FB7C2F5990356" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BS46</accession>
    <name>A0A9X0BS46_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aldehyde dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_006633</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788169.1">
        <property type="nucleotide sequence ID" value="XM_056936234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BS46"/>
    <dbReference type="GeneID" id="81626483"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07144">
        <property type="entry name" value="ALDH_ALD2-YMR170C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000011">
        <property type="entry name" value="ALD5p Mitochondrial aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720:SF2">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="29"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5480739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="502" mass="54201" checksum="16F941216E8C5D4C" modified="2023-11-08" version="1">MSNLSVQLTAPNGRSYTQPIGLFINNEFVAAKGGEKITSINPSNEAEITSVHAAGEEDVDAAVAAARKALKDPSWKELPATDRGRLMLKLADLIEQHKETLATIETWDNGKPYQVSLNDDLGEVTNTLRYYAGWADKVHGQTIGTFPQKFAYTLRQPIGVVGQIIPWNFPLAMAAWKLGPALACGNTIVMKAAEQTPLSILYLATLIKEAGFPAGVINIINGYGRVAGAALVQHPGVDKVAFTGSTATGREIMKMAAGTLKNITLETGGKSPLVVFEDADLEQAAKWAHIGIMYNQGQVCTSTSRILVHDSVYDKFVELFKDVVKNTSKVGDPFQDETFQGPQVTKAQYERVLSYIEAGKSEGATLAAGGEAFKNVGDGRGFFIAPTIFTNVKDHMRIYREEVFGPFVVIASFTTEDEAVTRANDTTYGLGAAVFTRDIERAHRVAADIEAGMVWINSSNDSDFRVPFGGVKQSGIGRELGEAGLDAYSQVKAVHVNMGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSP7</accession>
    <name>A0A9X0BSP7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_006876</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788412.1">
        <property type="nucleotide sequence ID" value="XM_056936477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSP7"/>
    <dbReference type="GeneID" id="81626726"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053229">
        <property type="entry name" value="NADH-Q_oxidrdct_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024549">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019721">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 21KDA SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10785">
        <property type="entry name" value="NADH-u_ox-rdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12853">
        <property type="entry name" value="NADH_u_ox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal" evidence="2">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit C-terminal fungi" evidence="3">
        <location>
            <begin position="111"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5480982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="186" mass="20945" checksum="17103F26D6398B2A" modified="2023-11-08" version="1">MASDHSAVVVPPKQVATDYPLIDSDPHMRRVFRYARREDYAVAGATGAISPIAFWVMERVSPSHVGRGGFPPVMRLATAIGFIGGLHVLYQRSCNRFYGFTENSREVDMDMREMVDKVKKGEPLYGTSGMSSYLQGVAARNSRYSGLFVHVLPWFNIVNHDQHGVDTAKYYQQAERELEAERLSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BT11</accession>
    <name>A0A9X0BT11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789069.1">
        <property type="nucleotide sequence ID" value="XM_056936145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BT11"/>
    <dbReference type="GeneID" id="81626394"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5483097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="259" mass="27825" checksum="D19795A0DF25C4EB" modified="2023-11-08" version="1">MSAVAGSLGDSTSEASLDNNGLVFTRSIHQYSGLCYTNDHKWCSFLRSALSSPSTGPDQTNFETFASSLDSCDAIPWTIVNLGWGKSQSPQAAVPRGLVLFFISWLRVIHVGLRIELGLVAWSRPGPLPTVPSSTRVYHVSHATNASPRCLLKNSRPCHVITPPGGNGLITSSTRHQQSLLIPVTLTRSPVLALPGGQHGLDKFSAANDRSHEDSLTHFRLKCLAQGLVSTPAIGPQIGGFAMDYPHSTVNPVWHSNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUH8</accession>
    <name>A0A9X0BUH8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="3">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_005990</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789464.1">
        <property type="nucleotide sequence ID" value="XM_056935592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUH8"/>
    <dbReference type="GeneID" id="81625841"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="12">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5484194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="334" mass="37016" checksum="7478350ACF7E52F8" modified="2023-11-08" version="1">MSLGKKVTLNTGAPIPQLGFGTWQSAPGEVGNAVYEALKAGYRHLDLATIYQNQREVATGIKRAFKEIPGLKREDLFITSKLWNSQHRPEIVEASLDACLAELELDYLDLYLVHWPVAFKQGNEYFPRVEGSTVEGGDVVIDNEVSIVDTWKAMTKLPKSKARAVGVSNHTIEHLEAIIQGTGVVPAANQIERHPVLQSKDLVEYCQNKGIHITAYSAFGNNNVGVPLLITRPEIKEVADAVAKRTGQEVTGAHVILAWSQIGGHSVIPKSVTPSRIRDNFKEIELTSEEAEKVSALGKDRKRYNLPFPNYKPRWNINIFGEPEEAPATYKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUK1</accession>
    <name>A0A9X0BUK1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_004970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789766.1">
        <property type="nucleotide sequence ID" value="XM_056934572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUK1"/>
    <dbReference type="GeneID" id="81624821"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5484982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="67" mass="7791" checksum="8F0A925FFB8FD773" modified="2023-11-08" version="1">MLGSIHLRMTWLRISILPEDPVTESAILPLEAKDPHFWQKKDDYRQDVNAENFDYLGYLMRAPSVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUP9</accession>
    <name>A0A9X0BUP9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-ornithine N(5)-monooxygenase</fullName>
            <ecNumber evidence="5">1.14.13.196</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">L-ornithine N(5)-oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_005387</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790183.1">
        <property type="nucleotide sequence ID" value="XM_056934989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUP9"/>
    <dbReference type="GeneID" id="81625238"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000195">
        <property type="entry name" value="L-ornithine N(5)-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5485399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="495" mass="55723" checksum="94D6E4124FBB0B4A" modified="2023-11-08" version="1">MQSISRKAELPTLNEMTARSQTSGQRTRLRSVPAEEMHDLLCVGFGPASLAIAIALHDAMDPALTRTASTSSFAPKVAFLERQTQFAWHAGMLVPGSRMQISFIKDLATLRDPRSSFTFLNYLHNKNRLVHFTNLGTFLPARMEFEDYMRWCAQRFEDVVSYGEEVVEVVPGSKTDGVVDYFIVRSRNSATGKISSRRARKVVVALGGKPKMPPGFPQDARIMHSSKYCTGLPNILKNESASYNIAVVGSGQSAAEIFHDLQRRYPKCRTTLILRDTALRPSDDSPFVNEIFNPERVEQFYQLPQDERHARIARDKATNYSVVRLELIEEIYNAMYLQRIRNPDESTWQHRILPERKVARIEHHNPNSPMRIHVQSVNEDDTAHNETLDVDALMVATGYQRDAHEQLLEQVRALRPEGQSAWSTGRDYRVALDESKVSPDAGIWLQGCNEKTHGLSDSLLSILAVRGGEIVNSVFGDELTGVSAQVQDTPIRAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUS3</accession>
    <name>A0A9X0BUS3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SPT2 chromatin protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_005134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789930.1">
        <property type="nucleotide sequence ID" value="XM_056934736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUS3"/>
    <dbReference type="GeneID" id="81624985"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="106"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5485146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="39874" checksum="F31AA05AD9F064E1" modified="2023-11-08" version="1">MSFLDSVLTSLETGKPVPLSSPAAAPRSSVSAQVGNRKADSGHVAQAAGASSSGIKRKADDQLPRPSKPEVPPSSRTFPSRPAALPTASKPNASTSSPQMTNQGLSNSTSRSIPSAPSSALSAKPLPSKATPAKSAAPRPNLAKVPSAPAAAPRPAVTKATPVSSKPPPKGSFAALMQQAKAIQEKAPAPIGIVRHQKVQKERLSKVERRRRLEEAKAQTKAARTGKRTAPAAAASSSTTAVKRRTPEPLSYKGTAKPASNPEPIAYKGTAGRQSQRSSVERRPAKRRMDEYLATDEEDEGDYGGYEDQEDYYSDASSDMEAGFDDVREEEDAALKYARKEDEEELRREMVAKKEKLERQKKLEALAASRNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXX7</accession>
    <name>A0A9X0BXX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_003527</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790670.1">
        <property type="nucleotide sequence ID" value="XM_056933129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXX7"/>
    <dbReference type="GeneID" id="81623378"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04661">
        <property type="entry name" value="NUDIX_MRP_L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000018">
        <property type="entry name" value="39S ribosomal protein L46, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033650">
        <property type="entry name" value="Ribosomal_mL46_NUDIX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL46 N-terminal" evidence="8">
        <location>
            <begin position="65"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5488637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="340" mass="38365" checksum="6DB88503ABB79E14" modified="2023-11-08" version="1">MASGSNSARRVASLMRPSRLDPGVCRSCQESLGRRSYASAATAPTGVASSTAPVSTPSSAIEPVYTINAGVVLSRPPQITRDLEPFEKAFFFYQKRLNERLALPFTKYFYFKRGTPADVDWKNKIKERRTPARDVGNYNAYDNDAWNDELLLGAKESEPEHMVEALVHDAETTANATSQDTSKKEEIPRPFSRVTEADKKGDQRSLNRLLSRTLYLLVQSKEGYWKFPSMPIEKEETLREAAERTLAQTAGVNMNTWMVGFHPAGHHVYTNRKPHVDQVTGAVTHGEKTFFMKTRIMAGQADLSSSAEKLKDFKWLSKDEISKYVLPQYYSHIKNMLADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY98</accession>
    <name>A0A9X0BY98_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_004053</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791196.1">
        <property type="nucleotide sequence ID" value="XM_056933655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BY98"/>
    <dbReference type="GeneID" id="81623904"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="4"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5489163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="151" mass="16673" checksum="9C3A85411B226C84" modified="2023-11-08" version="1">MSLASGVSVQDECLTAFNEFRLSKGKTKYIIYKISDNKKDVVVDAVGHDQDYEVFREQLAASKDSQGRPAPRYAVYDVEYDLGGGEGKRSKIIFISWVPSDTPTLWSMIYASTREVLKNALNLSASIHADDKSDIEWKTVLSEASGGKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYM2</accession>
    <name>A0A9X0BYM2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SGF29 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_002408</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791970.1">
        <property type="nucleotide sequence ID" value="XM_056932011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYM2"/>
    <dbReference type="GeneID" id="81622260"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20394">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000055">
        <property type="entry name" value="SAGA complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047288">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047287">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="6">
        <location>
            <begin position="189"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5490841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="324" mass="35969" checksum="E2424CB5516A4A42" modified="2023-11-08" version="1">MSRNRPRPRDNGLGNNEEMELWTRICQDIRKSKEKFDQQASISAQIKTLVDKITREGNKPTISDHDQLDKWLRQSQRLSEEERAIMVDEPCDVVKNLELLTALRKASEAEAPSNRSAALSKSRKKRGEMENSAMDSASASGGDKSGRPKGAVPRSMSVSSNHARDGRSEGIAVKIEEGSEGTKGTMAERSGLLVVGALVVFKHNKNKQGVEGEGIQCIIKNISGDGSKKRWYDVQDPEPNENGEEGAVFRTTASSLIPIPQAGTPLPSFPVGKQVLARYPDTTTFYRAEVMGSKKDTYRLKFEGEEDDKEMETERRFVLEIPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYM9</accession>
    <name>A0A9X0BYM9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting/targeting protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Carboxypeptidase Y receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 18">Sortilin VPS10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">N7539_004443</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS10-related sortilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791586.1">
        <property type="nucleotide sequence ID" value="XM_056934045.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81624294"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000005">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 21" id="KW-0732">Signal</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040724379" description="Vacuolar protein sorting/targeting protein 10" evidence="21">
        <location>
            <begin position="24"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1385"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1443"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="22">
        <location>
            <begin position="49"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="22">
        <location>
            <begin position="729"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="676"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="683"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAJ5489553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1521" mass="169228" checksum="D059D81DBDF73E07" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYT2</accession>
    <name>A0A9X0BYT2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_004578</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000011">
        <property type="entry name" value="50S ribosomal subunit protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="118"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="49"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5491099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="312" mass="34528" checksum="58E92C19316FD9D9" modified="2023-11-08" version="1">MPPRLMALPTQLSQLIMRPAMQISPLGFLAPTLQQQQQQQSRCASILSSLSDNPSAYNKRIRRGRGPASGKGKTSGRGHKGQKQHGKVPAGFNGGQTPDIVVHGEKGWNNIFAADMAPVNLERIQEWIDQGRIDPTRPITIRELTHSRCIHQPKDGVKILGGSAAALKQPVHLVVSRASASAIQAVEAAGGSLTTRFYTRNAIRHILRMESHPFISLAWSPQSGPEALLKADGAPEDLSEANVMKARGLKYRLPDPTRRRDIEYYRDPAHRGYLAHLLKPMEGPSLFFRSPEERKSTAGTKKEKILPENRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZQ1</accession>
    <name>A0A9X0BZQ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_001533</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793167.1">
        <property type="nucleotide sequence ID" value="XM_056931136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZQ1"/>
    <dbReference type="GeneID" id="81621385"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16988">
        <property type="entry name" value="ANTH_N_YAP180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.150:FF:000004">
        <property type="entry name" value="ENTH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000025">
        <property type="entry name" value="ENTH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="4">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="430"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="495"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="442"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="543"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5492787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="605" mass="66041" checksum="5DE306E3A5614DDA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0A6</accession>
    <name>A0A9X0C0A6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein PNG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein png1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_001520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793154.1">
        <property type="nucleotide sequence ID" value="XM_056931123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0A6"/>
    <dbReference type="GeneID" id="81621372"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.620.30:FF:000004">
        <property type="entry name" value="Peptidase (PNG1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000011">
        <property type="entry name" value="peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF19">
        <property type="entry name" value="PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="7">
        <location>
            <begin position="251"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="411"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00071430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5492774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="452" mass="51257" checksum="9286ECC5CA03C6BE" modified="2023-11-08" version="1">MADGKPQRAAQPAPNTNGTNPGYDASSLSQQFEQLMRTKRFNQLHESARSRARSQSPAPSPSSFSIPPPSRAPPPPPSLGAEARPASQSQPSRPNPALRSLPIMPSPPQDASSMKFFNLLKVLSVTPTKYENPGLLDEALCTLPLDRLYSEAEEESQILNAQAASVGGKPEWGYQDCVIRALLKWFKRSFFQFVNNPPCSRCYMPTIAQGMTPPSPDETARGATRVELYRCSGSTCGTYERFPRYSDVWQLLQTRRGRVGEWANCFSMLCRAMGARVRWVWNSEDYVWTEVYSEHQRRWIHVDACEEAWDQPRLYTEGWRRKLSYCIAFSIDGATDVTRRYVRNFSKHGSPRTRAPEEVVLWSIREIRRQRRENLAKTDQRRLMKEDEREERELRAYTVSALAAEIQNILPRSLSGRPGEQKHADARQEAATEWLSARGHGHSGPDRSNGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C1U4</accession>
    <name>A0A9X0C1U4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_000033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793930.1">
        <property type="nucleotide sequence ID" value="XM_056929637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C1U4"/>
    <dbReference type="GeneID" id="81619886"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5494917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="92" mass="11069" checksum="3A97B3FCB3758546" modified="2023-11-08" version="1">MQGLRCALGTQIVVAGPWLQGEVYYYYYYYYYYYYYYYSYYCNKNPLIINLKLTLSSEQQAISHRAISTFPQSRRLSFARWNREGEAAPFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2K3</accession>
    <name>A0A9X0C2K3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="2">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_000275</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794172.1">
        <property type="nucleotide sequence ID" value="XM_056929879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2K3"/>
    <dbReference type="GeneID" id="81620128"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="10">
        <location>
            <begin position="27"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="9">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5495159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="297" mass="32739" checksum="27DFBD65331E8AC1" modified="2023-11-08" version="1">MTYTITDRLPLPNSAGRIPRLGFGVYRSPASQCVQSVLKALQAGYRHIDTAQFYGNESEVGEALRTCGIPRDEIFVTTKILSPAGSPEQTYEKLLASVEKIGGTDGYVDLFLIHSPKSGPAGRKELWQALEKLQAEGKAKAIGVSNYGVQHIEEMKPYAKIWPPHVNQIEDVEANDLAVPPPPSKQLHPWCQQRTIDAYCKQHGIVVEAYSPIVRNYKANDPTLVEIALKYNHSTQQVLIRYALQKGWVPLPKTDNPDRIVANADVFGFDLSAEDMDTLDSLDQGEAGAIVEAVANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2K9</accession>
    <name>A0A9X0C2K9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_000697</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794594.1">
        <property type="nucleotide sequence ID" value="XM_056930301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2K9"/>
    <dbReference type="GeneID" id="81620550"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF30">
        <property type="entry name" value="GLUCOKINASE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="7">
        <location>
            <begin position="16"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="8">
        <location>
            <begin position="219"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5495581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="540" mass="59085" checksum="1E5E3E505DCA7FDD" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2S1</accession>
    <name>A0A9X0C2S1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_000877</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794774.1">
        <property type="nucleotide sequence ID" value="XM_056930481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2S1"/>
    <dbReference type="GeneID" id="81620730"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5495761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="54525" checksum="B4A54772FDC35B4F" modified="2023-11-08" version="1">MQKITVGDVDISQLQTLCLLSILEFTAGNIVRAGFFTNTASYLIQNVRLNGLDTLVNNLDEERDERKLCYASIVMLQNLQGTVPSRHSGSPFDQRSSTSIFEDTTWQESYLKSTVEKLDIGIISASMYTTELWSLACEYALVHDKMDTLPPWHPQSDYTSVTYRHTEHESCMPLRFRLHASNFADHSPSDLSTNRSYWSPWLSFQMVWHAVPCMLNHPFLLSLRLRNFRRTMPQSFLRISFEQLTLHSGWIMHFIELIQLKEFEVSDPIIGHCVAIVGTIYLQHSFVEDPVFSTKAREGFTLCLEFLRGLSKRWSHVDRMAQKLEQLHNSILPEGGLPVDGRPSTRQKWTVNPQLLWNILVYSHVSKAPNPATDIFGPGLVHDTAAQSEPVSSGEIRESDLALIGSAGISGHRTVVPECVTYPSEQSAHQLSEASRHPSTVDRVMHPTQSVSLGTEDQDDLFLQMQDYGKAFEDWLSLSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2T1</accession>
    <name>A0A9X0C2T1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nuclear membrane fusion protein Kar5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_001053</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for nuclear membrane fusion during karyogamy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the KAR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794950.1">
        <property type="nucleotide sequence ID" value="XM_056930657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2T1"/>
    <dbReference type="GeneID" id="81620906"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048288">
        <property type="term" value="P:nuclear membrane fusion involved in karyogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007292">
        <property type="entry name" value="Nuclear_fusion_Kar5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012:SF1">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0415">Karyogamy</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040773440" description="Nuclear membrane fusion protein Kar5" evidence="14">
        <location>
            <begin position="26"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5495937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="58813" checksum="B8A6FC69317A8D1F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C311</accession>
    <name>A0A9X0C311_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Steroid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_000831</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794728.1">
        <property type="nucleotide sequence ID" value="XM_056930435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C311"/>
    <dbReference type="GeneID" id="81620684"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5495715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="323" mass="35119" checksum="F395160AF946F6D9" modified="2023-11-08" version="1">MGLTWSQFFPPAPGLTEANLPSQKGRVFMITGGYSGVGFELSKILYGAGGKIYIAGRSEAKAKTVIQAIESAYPNSGGEIVFLPLQLDDLTTIKPAVERFTRTESRLDVLFNNAGVSNPPPEEVSPQGHELQFATNCLGPHLLTQLLLPTLQRTALGAPAASVRVIWLGSIVVDMSAPSNGVNLDEIIQRDSRMNRNYTNSKTGNWFLADHLARQAGSSGVLSLVVNPGNLKSELTRHFPSWAPILLSPLLYPPIYGAYSELWAGISPDLTMEDGGKSIIPWGRLHPKPREDLLKAMKPKEAGGTGDAELFLRYCDDSIEQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C3C2</accession>
    <name>A0A9X0C3C2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_001085</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794982.1">
        <property type="nucleotide sequence ID" value="XM_056930689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C3C2"/>
    <dbReference type="GeneID" id="81620938"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056027">
        <property type="entry name" value="DUF7608"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF56">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24581">
        <property type="entry name" value="DUF7608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="674"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="383"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="915"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="936"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5495969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="947" mass="104694" checksum="A9540F97F1E0E315" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKC4</accession>
    <name>A0A9W9WKC4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">MATH and UCH domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_009517</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785607.1">
        <property type="nucleotide sequence ID" value="XM_056939112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKC4"/>
    <dbReference type="GeneID" id="81629362"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MATH" evidence="8">
        <location>
            <begin position="135"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="381"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="1171"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="834"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="907"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="835"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="868"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="907"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5466561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1218" mass="135701" checksum="5C05015B6E460F56" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKI3</accession>
    <name>A0A9W9WKI3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like 1-activating enzyme E1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_009426</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785743.1">
        <property type="nucleotide sequence ID" value="XM_056939021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKI3"/>
    <dbReference type="GeneID" id="81629271"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01492">
        <property type="entry name" value="Aos1_SUMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="7">
        <location>
            <begin position="18"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5466697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="425" mass="46787" checksum="2E05186FC90F3B0B" modified="2023-11-08" version="1">MAEVENGNTISADEIALYDRQIRLWGVQAQEKIRSSNILLITVKALANEIAKNLVLAGIGSLTIIDHEPVSATDLDASFFLEEAYKNEDVIKQGKNRAEVAGPQIHRMNPRVKLHIDTADVRSKQPDFFSQFDVTIATELDFASYTTINAACRIANRPFYAAGLHGLYGYVFADLISHDFVIEREKSNGPTRQQETLTRSVVSVAAKTEGEKSEKGSRDKVIELVTKRETYSPLQLANTSPLPEEFTNNPRRRKQVTPLLSCLRALWEFEKISAGRRPSFAHQDLEVFTRLARESHQELKLDLATLDSTFLRQFLQNLGCELSPVAAFVGGALAQDVINVLSAREQPLQNMLLFDGEKLAGPIYPLHPFFPPEMDVGSLAAVPPVANPIPMNPTTITNLASHPAPSAVLNSAADLPANPSLNPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKI6</accession>
    <name>A0A9W9WKI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785779.1">
        <property type="nucleotide sequence ID" value="XM_056939057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKI6"/>
    <dbReference type="GeneID" id="81629307"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040763182" evidence="1">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5466733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="141" mass="15463" checksum="A04B1C9C66A80717" modified="2023-11-08" version="1">MAGFPATVAVVSSFVQLVDCSATITCRIIDYICQAERVPEHLSRLRGQLPLFAMVLQSLQDPAVQRALTSEDGSRMDTSIAQIMSRLTDLEAMVFRLSEGSAKALEKLSSDIENDAKLMMIYATLVLSFQAVKLSLQSSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKX9</accession>
    <name>A0A9W9WKX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF427 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785971.1">
        <property type="nucleotide sequence ID" value="XM_056938594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKX9"/>
    <dbReference type="GeneID" id="81628844"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="entry name" value="Domain of unknown function (DUF427)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310">
        <property type="entry name" value="DUF427 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310:SF5">
        <property type="entry name" value="DUF427 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF427" evidence="1">
        <location>
            <begin position="5"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5469381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="99" mass="11188" checksum="D7E67D3DF7D0B008" modified="2023-11-08" version="1">MPTARAKLGDLVLAEADTWETVEGNVYFPRSAIKDPNVFVSSETKTYCPWKGEAEYYSVKNGDNVVKDAAWYYATPKEKAMNIKDHVAFYKSKVQVTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL13</accession>
    <name>A0A9W9WL13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Allergen Asp f 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785981.1">
        <property type="nucleotide sequence ID" value="XM_056938604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL13"/>
    <dbReference type="GeneID" id="81628854"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038903">
        <property type="entry name" value="Allergen_Asp_f_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25312">
        <property type="entry name" value="Allergen_Asp_f_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040954556" evidence="1">
        <location>
            <begin position="20"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5469391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="246" mass="24866" checksum="2D3827B663FAF2E0" modified="2023-11-08" version="1">MQFTKSILLLAALTTSTFALPTTVERRQDSSWLSVPSSGSYSTSGFGSATSATGSGNTYAGNVGSPYGSNIIEVSASDASQYKYVMEIQAPSTDSYTVAVWNKYGPDGRMDGWYGNACKTLTVPAGSSVYLAFDEDTDGGFAAAPGSIPTDSNGGYASTWGEFDFGSSANNAWSGFDVSAIAAQNAGLTVQGMKICDALGGTCSSITPGAAVVDNAYTAAETAIGGIGGNLGAGPVRLVATLGYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL89</accession>
    <name>A0A9W9WL89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2C-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_009197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786169.1">
        <property type="nucleotide sequence ID" value="XM_056938792.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81629042"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:ubiquitin ligase complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAJ5469579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="49665" checksum="D16C0F45D3B40B22" modified="2023-11-08" version="1">MSPALTPQGDEMPLHLHAELLPNIRQVTLYVSLPQLSTLQSNRPQVQLSESCKSVTVSLSPPFEHVTETLKLPARVSGAVGQNLNLSPSTPSAPRKPADSGFEYSLRMAIDPRDEPFISAPETVSDDHFPWTAADMSPRTRIRCRGCKTRFLKDVGATQSVQAEPSLPQSGWIWKDLPSGNWAEMMDFWHCHKPDPHEHDSKPEADAALKLEGETAQVKGFGADSRVEAIPGTVLIDVPSFLLCESDCINLKKTSEDVPETSTSAKYFARSLQCAKCNAFVGIEDPPARGWRLLKTNVSLNANPEGSPEDETAWQSHPVQQIVAAQLLELIERESARRFVVHYGHKDGLLLWVFNPNLRYSSSGSGHVVSAQNAMKVLHQSIPNVDELLTPEIGNPSPLSVEELELPAAVYRALEEALDKSNKMLPSTARCFNEWKVGLLHRYSRICTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLI9</accession>
    <name>A0A9W9WLI9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786330.1">
        <property type="nucleotide sequence ID" value="XM_056938953.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81629203"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
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        <location>
            <begin position="368"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5469740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="701" mass="80019" checksum="84AA2DF9722105C7" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQM6</accession>
    <name>A0A9W9WQM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786399.1">
        <property type="nucleotide sequence ID" value="XM_056938391.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81628641"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5471853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="122" mass="13973" checksum="08EFA2A4D0E73191" modified="2023-11-08" version="1">MALKTHFEILHIRLKSFFDTLHRKLKSLLRREQDLINARPDSWFLPWDTDPEAPTSTRVNTHSQASVDSRGLPVSYLLAPWDICPTPNTEESDEYEPPAPYMYSCNTTPSLPPLASVHLRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQQ6</accession>
    <name>A0A9W9WQQ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786488.1">
        <property type="nucleotide sequence ID" value="XM_056938106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQQ6"/>
    <dbReference type="GeneID" id="81628356"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5471942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="285" mass="31759" checksum="1F0AC31A1F3E330E" modified="2023-11-08" version="1">MSGVGEAAAAIAIVNLGLQVSKHALHYGTEVYGASDEAAKIQEQVRIICLYFAALNELRANQTSGSSSKVHTFILMFFKQCDMHLKALWRTLLTACHMPMDTAIDGVLRISCYRKLLWPCNKKRLHESLNCLKELKEDAFKILLLLGLLQRPRSGFVARLTAGIERSTEKIAQLWSEVKIKYSPGAESGKVQSLEDLQSWVPGAGPRNLPEVMALALGGPRFLLRATSEDMEARYIRETAERDFQELLSWEEANPPRLSQSQIDQALNEIQHADGVEDVADGDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WRI3</accession>
    <name>A0A9W9WRI3_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">N7539_008562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5471993.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="65"/>
        </location>
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            <begin position="53"/>
            <end position="64"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5471993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="110" mass="12721" checksum="B03ADBF07052D8D9" modified="2023-11-08" version="1">MPPRGLRLFGYYIANPRLEAYQRYLGECPIEEHRQSKWTTARRVDHNVQQQNQEERRRDLKEEDSNTGDNAVLFVLVSRRLSPAPALNVLALGPLGYAQVYRNARDNANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WRX1</accession>
    <name>A0A9W9WRX1_9EURO</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
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        <lineage>
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    <reference evidence="1" key="1">
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            <strain evidence="1">IBT 30728</strain>
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    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
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    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786688.1">
        <property type="nucleotide sequence ID" value="XM_056938306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WRX1"/>
    <dbReference type="GeneID" id="81628556"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5472142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
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    </evidence>
    <sequence length="83" mass="9618" checksum="BE3AD936933CD18B" modified="2023-11-08" version="1">MAIILVLHWRSKKWGVRKDETPRVNASVNTVNTWHGRLNSQASFIFYSLASLEPSVLFFVFNRDPNPLTLRYKSVSFFSTKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTF5</accession>
    <name>A0A9W9WTF5_9EURO</name>
    <protein>
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        </submittedName>
    </protein>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="KAJ5475187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="80" mass="9036" checksum="6A3C0F9F862CCC77" modified="2023-11-08" version="1">MSAAVGPFIAQLQQLPARSRQGLNNLRQRLFQQEAKPKKEGQLLRTSLNVHRPVWVTAGGGVYTSLAAVYLTMRYLKRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTF6</accession>
    <name>A0A9W9WTF6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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                <person name="Frisvad J.C."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="152"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5475164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="195" mass="21328" checksum="B147D956752C0F1D" modified="2023-11-08" version="1">METRNQANQPPQPSKEAAYAQASNPVPQTPSEQRAPAQSRQYGDPTASITRGPSSQPSSDEARNRLEAERQKHRDEMERSQEVDTEYGIEQQPAEGYIADTVARKGMGMQRAQAGAHAGPVGNARGPGHPGFGEERDLAANMDEKRADHDRVLAERVESSPGSDVAEREGVRDRKMQQNEEVERALKESSGTPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTM1</accession>
    <name>A0A9W9WTM1_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475141.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056937807.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040720058" evidence="1">
        <location>
            <begin position="21"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="289" mass="32546" checksum="FDE92F1294BF7399" modified="2023-11-08" version="1">MRIVTILLYALAWFFHLGNASKLATPAEMLAMYNAYALDFAKNGAQRTIGPALSGTEMANFGTFASRVYVNVRFPKKGIFLSSDPKFNRANVDEITKYLPRRPKYSVEQLLGKELTKMKMAHYQVLALVNDVVYRASSSSTSSITEKLGVYLPEYKYASAGIIGARQQEIFSQGLQKLFQNEFSKAKLESEKIKVPGTDLEYDYVSWKKTLASSGVPQADVVRWYSKDVWEKTTDNDVRLLRDHRVVTAAITWNLGSLDSVGSCTAFTKNFLPWYKSGTSQWCPRVFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVB1</accession>
    <name>A0A9W9WVB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">14-3-3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_007349</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787749.1">
        <property type="nucleotide sequence ID" value="XM_056936950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVB1"/>
    <dbReference type="GeneID" id="81627199"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="4">
        <location>
            <begin position="9"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5477205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="285" mass="31641" checksum="A5D36FAF93F81CFE" modified="2023-11-08" version="1">MVNTTDTVNSKTFLARLCEQAERYDEMVSYMKEVANIGGELTVDERNLLSVAYKNVVGTRRASWRIISSIEQKEESKGSEEHVSIIREYRQKIETELEKVCQDVLDVLDESLIPKAETGESKVFYYKMKGDYHRYLAEFASGNKRKVAATAAHEAYKNATDVAQTDLTPTHPIRLGLALNFSVFYYEILNSPDRACHLAKQAFDDAIAELDSLSEESYRDSTLIMQLLRDNLTLWTSSEGNEGVEGAAPSQDKPEEEAAAAAAAPAPAPAAEEKTEEAEPVQASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WW46</accession>
    <name>A0A9W9WW46_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_007490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787890.1">
        <property type="nucleotide sequence ID" value="XM_056937091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WW46"/>
    <dbReference type="GeneID" id="81627340"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43689:SF8">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43689">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="98"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5477346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="492" mass="53167" checksum="4832F49455EE59EB" modified="2023-11-08" version="1">MGNSISKGLTSLLVFLYGLFTVALYGLIAIQKGTFFKKRTERQNLELQLARDRLWNLSKDYAGLSHHFLTLADGFKFHFVSNEAPGAQAALASDRPLVIFIHGFPDSWAVWRHIASSSTLQTSANLVAIDMPGYGGTQGLDKYSATNLLEKLTELIIALRTQYGVDDSSQANKKRVTIVAHDWGCVLAMRLAAEAPSLAHRFIFTNGPLRWVILIPFAPHPQPSLARSNISRMLSSASKMLKTAIAAPLSAKTPLTQALRTLGPVAHQTLLSGYIFAMQLPPSLVVFCLTGGNYSLMSSIHKGSHGRGEYTPSDEGTSMASSMGPSAAEAKTQTSDGESYPSTIDFSHDFANIMNQANYYRQGAAVARWHKSAETVANLHSISASHQLRHPSGGTGLLDDGLPGALQAPATVFWGQHDVALSEAVCLDGLADYLTSNSQIVMLPESGHFTPIEPESRAALTKAVEWAISGEEGDIVAKVRECYPSVTLVARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WW89</accession>
    <name>A0A9W9WW89_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787965.1">
        <property type="nucleotide sequence ID" value="XM_056937166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WW89"/>
    <dbReference type="GeneID" id="81627415"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5477421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="451" mass="48620" checksum="832C4290BC12D8BA" modified="2023-11-08" version="1">MGAIVTNLVALPILGLIAIPMVLSAWVTLWVALATLFVRFSVVYLDVIYGFVVSFFTLPLSSSSFLSFAASEPVTPAAGNSRRNSAHGLMQSRWSHDDHLAPGVGAIQTNDESTKHDVKSYAQSMIEAHHLPSSSEPYIGLPVSGDERRDFEGVGGWRSYQYPSDQASRPRTAPSAQEKSFHSASNSSTQSLQGEHALEPEGFDADDLAWLSLNYRLELPSHLVRLGDHLRSAPGVNSPPNLDYYPHASGLGLHAMHPAQSASSRRSHSHSGARHHHRSHTTSALTTSERRTGDFLSLALSTRPESVNRFLSPSASRAGPFMTPQPFSASLSSARTPFTHDLSRSEAYLSRSADAASSFLPTSHGAGERQGPYGYFALQKIDRRDHQLPPSSVISSSSGSGATTPGLNPSGEDRDSSSLGLTRLMAHYPTGVRHRRRSIAGPHSRVVTNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WWD1</accession>
    <name>A0A9W9WWD1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788040.1">
        <property type="nucleotide sequence ID" value="XM_056937241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WWD1"/>
    <dbReference type="GeneID" id="81627490"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="358" mass="40467" checksum="C82EAE6F49C0CF46" modified="2023-11-08" version="1">MRKPSLSQAVHEILFPRQRQGDPGSFTAHVTRNLVPEVRIETNQFYGPLDCIEAQYPGLDYAHPPHRLRLSRFPWHRRLFRAFDELKLTEEEISELCCWEGTKSARQRYELEKNIRVRDTTGDTVRRATAAPSPTVTLHPHFYTLTEESDEEDYLDAFIETRSEDTVRASISRTSSVTSNVRNSLGDEEYSDDEMESCGVALNHRLMAATAARARGADVPLDEDYEQWLKDVNERGGYEWMVAAIRTNQPVDNPEAAASSPLASVSPHTELRGWERRGEEEAVLADEETRPLSASEPSTTSNGLYAHAIEPLRVQSAEFEHGLGPRNHYNWGGLFADNERNGNPAPQHHQSQGSNTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1W0</accession>
    <name>A0A9W9X1W0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788269.1">
        <property type="nucleotide sequence ID" value="XM_056936334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1W0"/>
    <dbReference type="GeneID" id="81626583"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5480839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="129" mass="14108" checksum="072EC441A1A2816D" modified="2023-11-08" version="1">MSDNVTDPPKRHWHGEAGNRYEHQNVWTHGGAKGPANRAPWALTPEQTMAADSSRRSSAASSSGSPPSTMNDRRRSSASSKSGPMFAGLQSVKRDSTDANMSARRASWNEQQQPGGFFSKLWEGYTRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2I6</accession>
    <name>A0A9W9X2I6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G2/mitotic-specific cyclin-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_006100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788626.1">
        <property type="nucleotide sequence ID" value="XM_056935702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2I6"/>
    <dbReference type="GeneID" id="81625951"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="237"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="330"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="334"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5482654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="470" mass="53060" checksum="A359D11694603C88" modified="2023-11-08" version="1">MVVARSLRSRGVMNENDENGPVTRMTRAKAALSTEGAADAVKKPLQTKRATATSGTQRPRAALGDVSNVNKAEAAEIKGAKKAVTSKAGLTSKATVQPGGIQKPSRANSSRTTTALKPREPNQKLPNKRPKVDDTKAEEQPRKKIGVVKEEKVIVKDGPELKEDDAVEVKAVLKDGGLGEDVVDLDTEDLDDPLMAAEYVVEIFDYLRDLEQTTLPNPQYIEHQPDLEWKMRGILVDWLIEVHTRFRLLPETLFLAVNIIDRFLSVEVVALDRLQLVGVTAMFIASKYEEVLSPHVANFSHVADETFTDKEILDAERHVLATLEYNMSFPNPMNFLRRISKADNYDIQTRTLGKYLMEISLLDHRFMSYPQSHIAAAAMYLARLILERGPWDATLAHYAGYDEKEIDPVFRLMIDYLHRPVSHEAFFKKYASKKFLKASILTRQWAKKYHKLYIDSSDSEPYTFIKDGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2J4</accession>
    <name>A0A9W9X2J4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abhydrolase domain-containing protein mpaH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788641.1">
        <property type="nucleotide sequence ID" value="XM_056935717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2J4"/>
    <dbReference type="GeneID" id="81625966"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5482669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="448" mass="50895" checksum="CB5A91F03E5F3AC5" modified="2023-11-08" version="1">MSSSPFRIVEHRVPCQHIREYPGATANEQEEPLHLAVKQYIPIDNPNPQPGDVTILGAHANGFPKELYEPLWEEIHARSEASGLRIRSIWMADVAHQGESGVINEDSLGNDPSWFDHPRDFLHLINVKRAEMPRPIVAYENGFPRANIGDNSAQLSLMHPRLLHTLVLLDPVIQRQTTQLDAEGMAEQVRRIAKTTQLSTYRRDMWPSRKAAAEGFKRSPFYQAWDPRVLDRWIKYGLRDLPTAVHPLDPNAVVDKQNPPVTLRTTLHQEVFTFSRPNYANRPGSGKPVNRVTHPDLDAEHPDTYPFYRPEPARIFSQLPYLRPSVLYIFGGKSDMCHPEMMADKLANTGTAIGGSGGVAKGRVRDVLLEDYGHLLAQEAVNECAEAAVSWLTPELRRWRDEEESFRSVWSRKSKVEKLTVDKQWYEHVPAPARRPNNGEKKSGESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2P6</accession>
    <name>A0A9W9X2P6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788804.1">
        <property type="nucleotide sequence ID" value="XM_056935880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2P6"/>
    <dbReference type="GeneID" id="81626129"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="153"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5482832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="237" mass="26856" checksum="3ACFFD9543475BA2" modified="2023-11-08" version="1">MSTSNVVETPLEPFVLLTPRLIVLPTPHAVSLQSYREFYASLHANEAFCKMAFGDRCPPRQWSDEETRDVIQKGDIGRCWKARGMGDFAVGLRPSDISMWSSKNIEILEGLDFTEDPRFDVHNLKEIVWVGYAGVRDGTTTSIPPRDAADAPFPPWNEMVEVRYGVSPMHWGQGIAKEAAEAVMHWAVETRGVTRFIAETERPNRRSARALEKLGFSLSGTDYWKEPSEIEWEKVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2P7</accession>
    <name>A0A9W9X2P7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formin GTPase-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788734.1">
        <property type="nucleotide sequence ID" value="XM_056935810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2P7"/>
    <dbReference type="GeneID" id="81626059"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formin GTPase-binding" evidence="2">
        <location>
            <begin position="336"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="813"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5482762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="870" mass="96764" checksum="A485935CAAC7157C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X547</accession>
    <name>A0A9W9X547_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribose 5-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056935404.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81625653"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1400.10:FF:000004">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="entry name" value="Sugar-phosphate isomerase, RpiB/LacA/LacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051812">
        <property type="entry name" value="SPI_LacAB/RpiB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004051">
        <property type="entry name" value="PRK05571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732:SF1">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="Ribose/Galactose isomerase RpiB/AlsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5484006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="162" mass="17224" checksum="D52D43D532BD5505" modified="2023-11-08" version="1">MPSELPPLRLVMACDEAGVPYKDAIKALLEKSPLVESIVDVGVNSTSDKTAYPHPAVEGAKLIRDGKADRGLFICGTGLGVAIAANKVPGIRAVTAHDPFSVERSILSNDAQVLCMGQRVIGVELAKKLAVDWLNYRFDPQSASAAKVQAITDYEKQFSGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5U3</accession>
    <name>A0A9W9X5U3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron-sulfur protein IND1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_005966</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789440.1">
        <property type="nucleotide sequence ID" value="XM_056935568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5U3"/>
    <dbReference type="GeneID" id="81625817"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001278">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5484170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="349" mass="38376" checksum="3B79AB70867D0775" modified="2023-11-08" version="1">MHHNFSVFRRLFTTSRSCLSHDNPLGLPRSGTPPSFPRRRGLPEKRRIRDVKKVVAVSSAKGGVGKSTVAGSYHPNHPCDQDRSDKHLVSLNLALSFARRGIKTGILDTDIFGPSIPTLLNLSGEPRLDEHNCLVPLTNYGLKSMSMGYLLPQTQTDSTTGEVPMDTTPITWRGLMVTKAMHQLLHSVSWGPLDVLVMDLPPGTGDVQLTINQEIIIDGAVIVTTPQDIALRDAVRGFGMFERMNVPVLGMVRNMAYFACPNCGHQTRIFSHGEDHHPHSHRVDRGVLAECKRLGVDFLGDIPLDAQVCEDADRGKPTVVAEESAEQSARRQAFLDVAEQVAGKIGLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X665</accession>
    <name>A0A9W9X665_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kelch repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789893.1">
        <property type="nucleotide sequence ID" value="XM_056934699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X665"/>
    <dbReference type="GeneID" id="81624948"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF4">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5485109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="36224" checksum="E6883BA4F9555103" modified="2023-11-08" version="1">MAIPAKCHKLQDDEILQRSSQVVSVIGDRVYVFGGELRPREPRDNDVHAVTLHDNATAEILSQPAASLSPSARVGTASAALNGKMYLFSGRGGVAMAPIDEQGSIWEYDPSTTSWCLIQPSMTGSTAVPAARSYHCMASDGKDTLYVHAGCPESGRLSDLWSFSVSRREWRECEAAPGPPRGGTSIAFTNGKLYRMNGFDGKTEQGGNLDIYTPESNTWETHVYSADGEHGPSPRSVSALLPISVRGRSYLVTLFGERDPSSLGHQGAGKMLSDVWAFDLERKNWETVELQGTKSPVARGWFDADVMSSSAVIVHGGLGESNERLGDLWKLEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6X9</accession>
    <name>A0A9W9X6X9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_005199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789995.1">
        <property type="nucleotide sequence ID" value="XM_056934801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6X9"/>
    <dbReference type="GeneID" id="81625050"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5485211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="91" mass="11744" checksum="E266B8D91248760E" modified="2023-11-08" version="1">MTYYYYYYYYYYYYYYYYYYYYFYYYYYYCGPLVKWFPTSLSAHRPRTGLSVFLHIPRCRDFLEFHLGTPFRYTFFSEVSFFFARPCGPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6Y5</accession>
    <name>A0A9W9X6Y5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_005487</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790283.1">
        <property type="nucleotide sequence ID" value="XM_056935089.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81625338"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16702">
        <property type="entry name" value="RING_CH-C4HC3_MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000287">
        <property type="entry name" value="RING finger membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057211">
        <property type="entry name" value="DUF7889"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056521">
        <property type="entry name" value="MARCHF6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
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            <end position="391"/>
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            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9W9X741_9EURO</name>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
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                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
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        </source>
    </reference>
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        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="845" mass="96300" checksum="C1F24950A0F0BFDD" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7A5</accession>
    <name>A0A9W9X7A5_9EURO</name>
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        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">N7539_005590</name>
    </gene>
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        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790386.1">
        <property type="nucleotide sequence ID" value="XM_056935192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X7A5"/>
    <dbReference type="GeneID" id="81625441"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF668">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="53"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5485602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="470" mass="51271" checksum="6ECCE571DFEBD7FC" modified="2023-11-08" version="1">MSIVQAPQQTGPTRDVETYHDHDDAEKAYAEKPTPTDDPFGNEENGEVKYRVMKWWQSGMLMVAENISLGILSLPSAVATLGIVPAFIIILGLSAISWYTGLIMGQFKLRYPHVHSMGDAGEMLMGKFGRELCYWGQLLFIIFLMASHILTFTVLFNTITDHGTCTIVFGVIGLVVSCICALPRTSEKVFIMSTVSAASILIATIVTMISIGVQAPDNVQNDIVTEPTFVKAFLAVTNIVFAFIAHVSFFGIMSEMQDPAEFPKSLAMLQIVDTIMYIVAAMVIYCYAGPGVSSPALSSAGPLMKKVAYGLAIPTVIVAGVVFGHVACKYIYVRIFRGEHAHHMHERSWLATGTWVAIGLTTWTIAWVIAESIPVFNDLLSLISALFGSWFSYGLPAIFWMVMNKGQWFSSPKKIFLFVINVAILGFACAILEYPSILTPSQCGLGLYVSGKSINKSTSSASWTCASNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7Q4</accession>
    <name>A0A9W9X7Q4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 24 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_005604</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790400.1">
        <property type="nucleotide sequence ID" value="XM_056935206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X7Q4"/>
    <dbReference type="GeneID" id="81625455"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000022">
        <property type="entry name" value="NADH dehydrogenase flavoprotein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1590:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005725">
        <property type="entry name" value="PRK07539.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371:SF3">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01257">
        <property type="entry name" value="2Fe-2S_thioredx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="242"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5485616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="293" mass="32897" checksum="5B2A787C5D919CD1" modified="2023-11-08" version="1">MASKLLPRASRWLRPTSIPQYRSFSAAPQRLSDALMVLAIARFRCALSISVYRREAEHQELTFLHSFQHRNKPENNPSVPFKFSEQNLKVVDEILKRYPPQYKKAAVMPLLDLGQRQHGFTSISVMNEVARMLEMPPMRVYEVATFYTMYNREPVGKYFVQICTTTPCQLGGCGSDAIVKAINEHLGITPGHTTEDGIFTYVEVECLGACVNAPMVQINDEYYEDLTPESIKSLLTALKESATTGAKEPAPGPKSGRKTCENSAGLTSLHEVPEWTPEQFMRKDGVFDGEAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7V2</accession>
    <name>A0A9W9X7V2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell morphogenesis protein Las1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_005684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790480.1">
        <property type="nucleotide sequence ID" value="XM_056935286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X7V2"/>
    <dbReference type="GeneID" id="81625535"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5485696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="45072" checksum="AEEDC2C536632774" modified="2023-11-08" version="1">MAKVHFTSWKDRAHLLEVRDEFYPPHSYKGPDMRPRACAKVAAWKLRGNIPHHVEATALLTDAILHDDGERNSIFSIRATYSAAFCRFVTGLVDTKTTGPRRTMFQRAMDLGLPASFVELRHEATHREPPSLIVLRKATQRSLEWLWDNYWTTLDPDGLSGSSSRADHSDLPTATALRQCLQGFMKNSKARLTQKKRKRDQETALADNLIGICRDSKDSVDSAMATLSVSLLELNALIDPNRSLGDSMDATFEKWDPILQRVTDARAAFLHCMAEELVNTMVLSSSADDHEIAHVEGLYLWLEHLITSTSWESRRQFLPREYLLAVCQSNPSRWTAILTAELRPLQHELLDGMRSSHTAKGPTSQKHVANWVLSKKLENYGWGLAESWDSRPLGVSVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XC43</accession>
    <name>A0A9W9XC43_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790619.1">
        <property type="nucleotide sequence ID" value="XM_056933078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XC43"/>
    <dbReference type="GeneID" id="81623327"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5488586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="332" mass="38494" checksum="552511137E6B35D7" modified="2023-11-08" version="1">MSRFRIPLASASRLNSLGGVSQTRPLYWDSTRVNSVQRYQDISETLSFITLELEKWQQQTSDFLRGITVYLFTDVRREWGNALFQAIDERFRVRKTWDSQARTLSLKMPTQGHDIAQKWVINSVVDWKDDGIISKEEWRGLKIGFGTTLKLPMSPFPKFQKEPDIYIRPYDSDSEFLPPIAFEIGWSENASRLKDDVRILLEGGGGHIRVVIVIDWYLQKDGLTVTGKVDLWRRGLDGHPIHEQSEDIYPVPRLLRGQGQRLGVTLDDIFLTTLRANQDPKTIVYFDIGQLREEADKARWFETTSRLKDDVRILLEGGGRHIRIGIIINWYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCE1</accession>
    <name>A0A9W9XCE1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger protein ZPR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003471</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZPR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790614.1">
        <property type="nucleotide sequence ID" value="XM_056933073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCE1"/>
    <dbReference type="GeneID" id="81623322"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="7">
        <location>
            <begin position="34"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="7">
        <location>
            <begin position="248"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="423"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5488581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="462" mass="51682" checksum="48257C5B423149E1" modified="2023-11-08" version="1">MSTDADSNPQESQFQNIGDLVERNDETGVMSVESLCMNCHENGTTRILLLRVPFFKDIVVDSFYCEHCNFANNTVKPAGPISPLGLKYTLDVQNPNDLQRQVIRSDAATFKLDTLGIEMPKGGEISNVEGMIQRMHESLSSEQPLRKEQAPELHDALEPIIAKLKAILDREFFPFTITLDDPTGNSWIAPNPSDKTNYRRVEYPRTHEQNEELGITADHTEQAVANAVDTENPMDSDIVDGQVYTLPAECPSCTRPVALHIKKVSIPYFKDVLIMASSCAPEDGGCSYKQNEVKVGGEIPEKGRRITLRVENEVDLNRDVLKSGTCALHSEELELYLGASSISSRFTTVEGLLTDMRKQLHGNLYDLGSGGGDSMEKSDKEKWDRFFDRLDQAINGELKFTITLEDPLANSYVQDLCSPAKDPQLNIEDYERTDEENEELGLNDMKTEGYEEDAKAENEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCI1</accession>
    <name>A0A9W9XCI1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mannan polymerase II complex ANP1 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_003637</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790780.1">
        <property type="nucleotide sequence ID" value="XM_056933239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCI1"/>
    <dbReference type="GeneID" id="81623488"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF2">
        <property type="entry name" value="MANNAN POLYMERASE II COMPLEX ANP1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="389"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="389"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5488747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="434" mass="50042" checksum="1E35FFEEF6FD7B83" modified="2023-11-08" version="1">MNRHYASPKGHSAFPFPIASNRFQPRPQPAFRRRRQLFHRLLLLGGISFLLFLLIFPSWRAAILPAISLGLVNHSEELHHLQTVRYYDLSDVQGTEKGWERGERVLMLTPLRDASSHLPMFFSHLRNLTYPHNLIDLAFLVSDSRDDTMEMLSRMLQEVQDDPDPKMNFGEISVIQKDFGQKVQQDVESRHGFEAQASRRKLMAQARNWLLSATLRPTHSWVYWRDADVETAPTTIIEDLMRHNKDVTVPNVWRPLPDWLGGEQPYDLNSWQESETALALADSLDEDAVIVEGYAEYATWRPHLAYLRDPYGDPDMEMELDGIGGVSILAKARVFRSGVHFPAFSFEKHAETEGFGKMARRMNFSVIGLPHYTIWHLYEPSLDDLRHMEEMDREREAREEEERQRQSQEQEKGHDDAKSGRSSASDAGSSEKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCX9</accession>
    <name>A0A9W9XCX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_003342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790485.1">
        <property type="nucleotide sequence ID" value="XM_056932944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCX9"/>
    <dbReference type="GeneID" id="81623193"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="165"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5488452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="390" mass="44502" checksum="E20426D98280DB0D" modified="2023-11-08" version="1">MSGKRAFELEAQHGRQSKAARFNVHVLKKLQAAITEDPEINLVERLPADYTQRLMEMRKPLESSPKKIKYNQPDSVEGDEDIRRSLCPSDPVEIVFPLSDAVEKLIEPVSQTAEVLPVGLSQRLFEVLENSEILWKAPFARQKGVFKCSAEIVVKAVRNMEHYTEYTALQYLDRHKSNIPAPKPLGLVRMSGITLIFMSYMGSAPLGEVWHTLDSCQKTSLSNQLNTILEDLRTLPFTEGSPLGGVAGEGCRDLRRHVRTSKTPITSLEDFETFLFASSHPGGSVFVEFLRRLSPSLTDHTGPRIVFTHGDIRPDNIMVELDENKKYIVSGILDWEYSGFYPDYYESVRCTNCLSPYEEDDWFLYLPECVSPNTYAQWWLFDRVRETRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XD47</accession>
    <name>A0A9W9XD47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_004001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791144.1">
        <property type="nucleotide sequence ID" value="XM_056933603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XD47"/>
    <dbReference type="GeneID" id="81623852"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000638">
        <property type="entry name" value="Transmembrane GTPase Fzo1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF0">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="310"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="36"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="534"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="541"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5489111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="962" mass="105543" checksum="15531FF55D60A3D9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XD84</accession>
    <name>A0A9W9XD84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_003966</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791109.1">
        <property type="nucleotide sequence ID" value="XM_056933568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XD84"/>
    <dbReference type="GeneID" id="81623817"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="443"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
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        <location>
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            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
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        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5489076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="529" mass="55595" checksum="F533DC88BCA5C25B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDP8</accession>
    <name>A0A9W9XDP8_9EURO</name>
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        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_004370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5489480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056933972.1"/>
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    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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    </feature>
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        <location>
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            <end position="26"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5489480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="759" mass="85071" checksum="49ED72FE6DEB0F7D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDU9</accession>
    <name>A0A9W9XDU9_9EURO</name>
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        <recommendedName>
            <fullName evidence="8">Actin binding protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">N7539_004454</name>
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    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
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            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056934056.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81624305"/>
    <dbReference type="Proteomes" id="UP001148312">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:site of polarized growth"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11962">
        <property type="entry name" value="SH3_Abp1_fungi_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3_Abp1_fungi_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Actin binding protein, putative"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SH3_domain"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF25">
        <property type="entry name" value="DREBRIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
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        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <location>
            <begin position="5"/>
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        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="739"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="319"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="693"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="471"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="533"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="549"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="721"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5489564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="797" mass="84804" checksum="FE31D6F27120E65E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEC7</accession>
    <name>A0A9W9XEC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Folliculin-interacting protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791516.1">
        <property type="nucleotide sequence ID" value="XM_056933975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEC7"/>
    <dbReference type="GeneID" id="81624224"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028084">
        <property type="entry name" value="FNIP_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634:SF9">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14636">
        <property type="entry name" value="FNIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Folliculin-interacting protein N-terminal" evidence="2">
        <location>
            <begin position="85"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="829"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="723"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1207" mass="130525" checksum="F06E782B8DA46DC9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XED9</accession>
    <name>A0A9W9XED9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002292</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791854.1">
        <property type="nucleotide sequence ID" value="XM_056931895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XED9"/>
    <dbReference type="GeneID" id="81622144"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000006">
        <property type="entry name" value="NOL1/NOP2/Sun domain family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049561">
        <property type="entry name" value="NSUN5_7_fdxn-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048889">
        <property type="entry name" value="NSUN5_RCM1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF4">
        <property type="entry name" value="28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21148">
        <property type="entry name" value="NSUN5_fdxn-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21153">
        <property type="entry name" value="NSUN5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="135"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="547"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="250"/>
            <end position="256"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5490725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="602" mass="66368" checksum="AD78DB420CA58BF9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF95</accession>
    <name>A0A9W9XF95_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DSC E3 ubiquitin ligase complex subunit A</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Defective for SREBP cleavage protein A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">RING-type E3 ubiquitin transferase dscA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">N7539_002686</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic component of the DSC E3 ubiquitin ligase complex which is required for the srbA transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. Required for growth during hypoxia and triazole drug susceptibility, as well as for virulence in a murine model of invasive pulmonary aspergillosis (IPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the DSC E3 ubiquitin ligase complex composed of dscA, dscB, dscC and dscD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792248.1">
        <property type="nucleotide sequence ID" value="XM_056932289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF95"/>
    <dbReference type="GeneID" id="81622538"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000626">
        <property type="entry name" value="Transmembrane ubiquitin ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021319">
        <property type="entry name" value="DUF2921"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF162">
        <property type="entry name" value="TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11145">
        <property type="entry name" value="DUF2921"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 22" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040814911" description="DSC E3 ubiquitin ligase complex subunit A" evidence="22">
        <location>
            <begin position="23"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="23">
        <location>
            <begin position="735"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAJ5491119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="805" mass="89864" checksum="6F0E42DD05566B26" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFF6</accession>
    <name>A0A9W9XFF6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792338.1">
        <property type="nucleotide sequence ID" value="XM_056932379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFF6"/>
    <dbReference type="GeneID" id="81622628"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="226" mass="25415" checksum="D03AE9E6C5E30BDF" modified="2023-11-08" version="1">MDSTLQQFPPPPFPPLHITTDTYTPSSFHRRPSSETSSSSSSRATSPPASPTTTLRRHHHHHHHQLKDQTSPHHLFNLSFHPSTVHAKEEFGADRNPTVRQGRARESYSPPRTSRWGVDILKGSVLRGRSSLMVLRRRPSAVDRALSEERSRCDEDAIERQGLDLMEPRPVDMQLPITMLMEEPAAIHRRSPSTSSGRSDPDSRSTAAHHPCFVMGGIFEVMEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFS0</accession>
    <name>A0A9W9XFS0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_002344</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791906.1">
        <property type="nucleotide sequence ID" value="XM_056931947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFS0"/>
    <dbReference type="GeneID" id="81622196"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407:SF1">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCNT-C" evidence="4">
        <location>
            <begin position="254"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5490777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="353" mass="39714" checksum="4EE7984478DBA42E" modified="2023-11-08" version="1">MCADINTTTALDLDDEPYESAEDEDFQLDAAQDESELSSDDEDSNEPAKKKRRTEKSQDVVDAELDSGDEITIQKAREGGGQPGKTRVNDQEYEVGEDEETGTWGFVRTRAMKKHIQEEERKPLARIDGATVDVDALWAQMNTLDNQAGVSQPSEDQKEETAPAAIPSGRHTRAPSKEQMVKIRRTYKFAGEMITEEKVVRKDSAEAKAFLSGENAEFTEVLDGDRAKGMRDLRRPLRKFSRFDPNPPDTIKKSWERQAITDATADATGPKINTVEKSRLDWAQYVDKAGIKDELRTHSKAKEGYIGRMDFLGRVETKRDEEARQARLRGSLKRPGIFKRAICLSLQDMPTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG00</accession>
    <name>A0A9W9XG00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003108</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792670.1">
        <property type="nucleotide sequence ID" value="XM_056932711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG00"/>
    <dbReference type="GeneID" id="81622960"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF152">
        <property type="entry name" value="OXIDASE (CODA), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5491541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="542" mass="59689" checksum="7394058CF5AA9AAE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG08</accession>
    <name>A0A9W9XG08_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SAGA complex subunit spt3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_002494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SPT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792056.1">
        <property type="nucleotide sequence ID" value="XM_056932097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG08"/>
    <dbReference type="GeneID" id="81622346"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22926">
        <property type="entry name" value="HFD_SPT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="384"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5490927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="461" mass="51620" checksum="998002DDDE64043E" modified="2023-11-08" version="1">MAALKAQLRPKWSFKPILISDDARSLSSCSHYSTCLEYISDSPTHVPALAQGVQNPTPPSTAGFEAPRLFKSSSRRLSDASDTSSFYDGHHKTGAFSFCGKNRKSKSDHETKPAEPAGTISETYDAEDEMDFDSFMYPSAALFDYPFTDELLLQMMFVSGETAEASVETTTLIEDITREQVLEILTRGAQMAARRGSRSISTDDLIFLIRHDKAKVSRLRTFLSWKDVRKNVKDSDDKGGADAADFAAADDAAGVVAGPQDVASKPKNKRAKVGLAWDVNSFFSVQIPEREDEEDEEEEEQNYATLQRLAAADERTKHMTKEEYVVWSECRQASFTYRKSKRFREWAGFGIVTESKPNDDIVDILGFLTFEIVQTLTEEALKVKEREDHEKNRGGADASGADNKKRKRETGLFDPPEEGRTPVEPRHIREAYRKLQATPQKSIAMLLHNGRVPAKLPLKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGB3</accession>
    <name>A0A9W9XGB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="2 13">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_002970</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Chromosome</location>
            <location evidence="13">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2 13"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792532.1">
        <property type="nucleotide sequence ID" value="XM_056932573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGB3"/>
    <dbReference type="GeneID" id="81622822"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01648">
        <property type="entry name" value="TERT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
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            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAJ5491403.1"/>
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            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGD9</accession>
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        <recommendedName>
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        </recommendedName>
    </protein>
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            <taxon>Eurotiomycetidae</taxon>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="666"/>
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        <location>
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            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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    </feature>
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        <location>
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        </location>
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        </source>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5491433.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="890" mass="98948" checksum="24FB0D3A864A0C6A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGZ1</accession>
    <name>A0A9W9XGZ1_9EURO</name>
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        <submittedName>
            <fullName evidence="9">Splicing factor 3B subunit 4</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">N7539_003155</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
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        </lineage>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056932757.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81623006"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:precatalytic spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12334">
        <property type="entry name" value="RRM1_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12335">
        <property type="entry name" value="RRM2_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000121">
        <property type="entry name" value="Splicing factor 3b subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000288">
        <property type="entry name" value="Splicing factor 3b subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034158">
        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034159">
        <property type="entry name" value="SF3B4_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="101"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="268"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5491588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="417" mass="45628" checksum="0BBCEB75E6050E78" modified="2023-11-08" version="1">MSGARHWEQDKEATVYIGNLDERATDSLVWELMLQAGRIVNVHLPKDRVTQTHQGYGFVEYISEEDAEYASRIMNGIRLYGKPIRVNKASADKQKSVEIGAELFIGNLDPMVSEQILYDTFSRFGTLTSLPKVARDDNNLSKGYGFVSFADFESSDAAINNMNGQYLMNKQVSVQYAYKKDGKGERHGDEAERTLAAQARKHNVRPPTQQVAPPQFPGAAAAPPPGAGATTPAALPNGEASRPVSTAPQTPDVGMGRGMPMPMNYQSVPPPPPQQGRPSGPPPASLMTPPPGLPARPPPSQAGYGGPQTYLPPKFNGAGPQAPFPLPRLELLLHHLAWPLLALRRPQQARWHLVHHLHFLLVSSRQVMGLVAEEGLMVPETWKTGHSRVEYITHSFRYRPVIEIGSESDGTASDFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH04</accession>
    <name>A0A9W9XH04_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GCS light chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Gamma-ECS regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Gamma-glutamylcysteine synthetase regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamate--cysteine ligase modifier subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_001613</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a catalytic heavy chain and a regulatory light chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793247.1">
        <property type="nucleotide sequence ID" value="XM_056931216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH04"/>
    <dbReference type="GeneID" id="81621465"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035226">
        <property type="term" value="F:glutamate-cysteine ligase catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000026">
        <property type="entry name" value="Gamma-cysteine synthetase regulatory subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032963">
        <property type="entry name" value="Gclm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295:SF4">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="10">
        <location>
            <begin position="88"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5492867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="314" mass="34284" checksum="6DA2F36E99590621" modified="2023-11-08" version="1">MKLILSTSNIMNSGPPSVIRHPMMQKSNIELITSLRSNFVASQTLDNTGVDGANCAANGQHGNVASWTENCEDGLYIPAVDFSQHGLAEERDQYDITVKLFYLPGIPASRRCAHTREAIDLVLRELHVKSIDLLIVSFPGILFDADDDSDEEGSDASGEDDFDSMVQTWRVLESLHEQGVIAQMGVAEFGSERLARFLPHTQVKPTVDQINLKDCCVVPKSLILYAKQEKIQLLTHNDCNDILPVGMTRELLGPKDQGGAGILASAPDANDGIQGDVEPQWVVKYTAVVKDRGVVENKGYFALADVGTCVQSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH42</accession>
    <name>A0A9W9XH42_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_001617</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793251.1">
        <property type="nucleotide sequence ID" value="XM_056931220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH42"/>
    <dbReference type="GeneID" id="81621469"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.190:FF:000002">
        <property type="entry name" value="Translation initiation factor 2, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5492871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="309" mass="35160" checksum="EAE81405C7FD0D0B" modified="2023-11-08" version="1">MSLTNCRFYEEKYPEVDSYVMVNVKQIAEMGAYVKLLEYDNIDGMILLSELSRRRIRSIQKLIRIGRNEVVIVLRVDKEKGYIDLSKRRVSPEDVVKCEERYNKSKAVHSIMRHVAEATQTPLETLYQQIAWPLNRKYGHSHDAFKISITNPDVWNEIEFPNDVVKKELQQYISKKLTPHPTKVRADIEVTCFGYEGIDAVKEALRTAEANNTPENQIKVKLVAPPLYVLTNQSLDKNQGIQMLEVAIENIAAKIKEAGGNCTVKMAPKAVTEQDDAMLQELMDKRERENMEVSGDESASESDEGVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHI0</accession>
    <name>A0A9W9XHI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Grh/CP2 DB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_001847</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793481.1">
        <property type="nucleotide sequence ID" value="XM_056931450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHI0"/>
    <dbReference type="GeneID" id="81621699"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057520">
        <property type="entry name" value="GRHL1/CP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF20">
        <property type="entry name" value="PROTEIN GRAINYHEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25416">
        <property type="entry name" value="GRHL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51968">
        <property type="entry name" value="GRH_CP2_DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Grh/CP2 DB" evidence="8">
        <location>
            <begin position="290"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="515"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5493101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="797" mass="88900" checksum="C2E162033B0A119F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI21</accession>
    <name>A0A9W9XI21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_001989</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793623.1">
        <property type="nucleotide sequence ID" value="XM_056931592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XI21"/>
    <dbReference type="GeneID" id="81621841"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF12">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="3">
        <location>
            <begin position="213"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5493243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="62649" checksum="FF03A84E19B919BD" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI36</accession>
    <name>A0A9W9XI36_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_001681</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793315.1">
        <property type="nucleotide sequence ID" value="XM_056931284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XI36"/>
    <dbReference type="GeneID" id="81621533"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF13">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5492935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="381" mass="42656" checksum="41ED9D612C8506A4" modified="2023-11-08" version="1">MHQSRSYRKLIKPLVLRDPDVFLLTPNYSPENGSLWYYAPDKGAPIVFALLFAISEIVHLYQTWYVHRKCPMLTIIVSLHHQLQAPAKNHSVIRKYKSWKVTGLLPWSALLFAAGLGRDAIYWSLWPVGQYRGIHCKYSATSRCTVILSMRSPTTLFSAGFCTTFHTTRRFTLVVSSPLLTVSAVIEASTANGAAQVAGADSSPTSVSTGKALLKAALLLHIILMVAFVTMAGRFHYNCVKNRVFNRKIRRALIVLYISSTLITTRTIYRTVGFFSTASLKTSALEWYFCVFEAVLMFCNRILLNAFHPMHSLPLSNTVYLAEDGVSEIEGPGYKDPRRLIMTFIDPFDICGLILRRDRHAKYWESGSADGTVSPCAGAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XL88</accession>
    <name>A0A9W9XL88_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_000054</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793951.1">
        <property type="nucleotide sequence ID" value="XM_056929658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XL88"/>
    <dbReference type="GeneID" id="81619907"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5494938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="156" mass="17865" checksum="8A446338641A4DEA" modified="2023-11-08" version="1">MSFLSVFRTASRAVRPASVVRAPLVRSQMQIPVTLAARTANFGTTRMLRSGHEDETYEEFSARFEKEFDGVQDVFELQRNLNNCFAYDLVPSIEVLTAALKAARRVNDFPTAVRVFEGIKAKVENQDQYKQYLDQLDGLRQELGVALREEMYPHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLU7</accession>
    <name>A0A9W9XLU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lactose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_000460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794357.1">
        <property type="nucleotide sequence ID" value="XM_056930064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLU7"/>
    <dbReference type="GeneID" id="81620313"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000217">
        <property type="entry name" value="MFS lactose permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF70">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14540)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="61"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5495344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="538" mass="59093" checksum="F5EAD668EBEAB2DA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLV3</accession>
    <name>A0A9W9XLV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein psi1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_000538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794435.1">
        <property type="nucleotide sequence ID" value="XM_056930142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLV3"/>
    <dbReference type="GeneID" id="81620391"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000136">
        <property type="entry name" value="DnaJ domain-containing protein Psi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5495422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="377" mass="40182" checksum="CDF84CA2EB2F0EBA" modified="2023-11-08" version="1">MVAETKLYDALSIQPSASQDEIKKAYRKAALKWHPDKNKNDPKASEKFKEVSQAYEVLSDPEKRKVYDQFGLEYLLRGGPAPSPGGGGGGGGAGPGGMPEGFGFGGMPSGGGGTRTFHFSTGRGGNGGFSFSNADDIFRNFAKSSGGMGGGVGGMPGGFDDDILSSMFNGMGGAGGGGFRSRPSTGNFSSAKANRAPTPEPTVIEKDLPVTLDEVFKGVKKTVVAKSKSFDTSGKRTVKDVPLEAVIKPGMRAGTKIKYRNIGDGEEGGRQDMHLIVKYIDHPDFKLERDNLVTTVELSLKEALTGWERIVRTIDGKSIRVSKPGPTQPGHEEHYPGWGMPNPRKSGERGDLVVRVKVNFPKTLSSETKTILKDLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM41</accession>
    <name>A0A9W9XM41_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7728 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_000206</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794103.1">
        <property type="nucleotide sequence ID" value="XM_056929810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XM41"/>
    <dbReference type="GeneID" id="81620059"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056145">
        <property type="entry name" value="DUF7728"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24854">
        <property type="entry name" value="DUF7728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040735404" description="DUF7728 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7728" evidence="4">
        <location>
            <begin position="100"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5495090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="394" mass="43193" checksum="7F10B0EDB900F683" modified="2023-11-08" version="1">MLARSLMLLGGAAVLPASSMLIPPEMEHQMEPVQDGFMNVHPVILADAHHAMVSVPCQDCPFREVDHEGVATWVEGKSPSLPSHPLIGRERPPLNKSVLTHDSGQMLDFSIEDNLLLANGRQIFPPVDPGPLRAIQQLQDGQISEPMALGYALEMMPLETSDKDAGSEIYDVRLTILDLERHPVPVDTVAVTLLQAPDGELFIAKTKIEPTAPPSSDLSWKKCDGKVACLRELAIARVRGLLAAAKGRVAAAAGKTGRKGCHGKHNPAKGMGAFSEFEKEHHWGGHRHHHHHHRPHGAFVRTFRRIIHFIIVPALVGILAGVAASSIGMLIGQAVVFMWRRYRVGQPQEHKASWEQGESCEKQSLIEDSVEVSEQDDLPQYTESVTPRGSMDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMI4</accession>
    <name>A0A9W9XMI4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial Rho GTPase</fullName>
            <ecNumber evidence="15">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">N7539_000869</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion outer membrane</location>
            <topology evidence="2 15">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="15"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794766.1">
        <property type="nucleotide sequence ID" value="XM_056930473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMI4"/>
    <dbReference type="GeneID" id="81620722"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01892">
        <property type="entry name" value="Miro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000127">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000185">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000572">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000878">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021181">
        <property type="entry name" value="Miro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037488">
        <property type="entry name" value="Mt_Rho_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 15" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="19">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="186"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="19">
        <location>
            <begin position="422"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ5495753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="634" mass="70148" checksum="1BA0AEBFEFAA3101" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XML1</accession>
    <name>A0A9W9XML1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chlorophyllase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_000913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794810.1">
        <property type="nucleotide sequence ID" value="XM_056930517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XML1"/>
    <dbReference type="GeneID" id="81620766"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33428:SF14">
        <property type="entry name" value="CARBOXYLESTERASE TYPE B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33428">
        <property type="entry name" value="CHLOROPHYLLASE-2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5495797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="36665" checksum="2248A2C1259C338D" modified="2023-11-08" version="1">MTVDQRSPKKPTVRRANLPDHALIGDAAKLPINATQPVISMSPLVLPAPDRIMDLHLRVSAPVIGENLPIILLSHGQGPSNNLSSLNGYAPIANFWASHGFVVIQPTHLGSRSLNLTIQDDPEAPWFLESRVADCKLIIDELDQIETLFPNIKGRLDRGRIAVVGHSGGGHTASRLLGARGTNPSLKSFENAREPRIKAGVLLASPGDGRNGDGMGPAALNTELIYHSHADMSAPAMVVIGDQDGFPFLTTRGAEYHADAYHHSPGPKSLLTVKDGKHGLGGVSGYDVAEATDDESPERLAMVQRTTWAYLRSALYPDDQAWSEARAALKALPHLGAAEDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMM5</accession>
    <name>A0A9W9XMM5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">L-pipecolate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_000878</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794775.1">
        <property type="nucleotide sequence ID" value="XM_056930482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMM5"/>
    <dbReference type="GeneID" id="81620731"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF45">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="9"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="391"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5495762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="429" mass="46542" checksum="91FFAD153F6BFA03" modified="2023-11-08" version="1">MATCESDSIIIVGAGVFGLSTALELNRRGYKDITVLDRYNPPAADGSSVDISRIIRIDYADPVYCKMASEAYQGWQTEYKDHYYESGFALLSQTPDNEWIAKSAATVKANGGTVEDLDDARQLLRSFPNIQSDLAGMNGYLNRRGGWADAASSIQKLASQCSVAGVSIISGPRGSVSSLLKKGSRVVGVNLVNGSSLRASRVILSTGAWTNRLLNITHAATSSGQPVGFIQLTRDEARSLDNTPVMIDMSTGVFVFPPTPGSNILKLARHGYGYANEVAIQLDGATHTVSAPKFDSSNAGTGYIPQDADDDLRKGLKRFFPKFADRPWMNRRLCWYTDTPKGDFIIDNHTSLQGLFVATGGAGHGFKFLPVLGKYIADCFENKAPAELREKWRLQEAPRESPAEKSMKGDGSRAGPPLRKLTSTEKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN55</accession>
    <name>A0A9W9XN55_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ribosome biogenesis protein bms1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_001163</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795060.1">
        <property type="nucleotide sequence ID" value="XM_056930767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN55"/>
    <dbReference type="GeneID" id="81621016"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="12">
        <location>
            <begin position="62"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="403"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="582"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="638"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1125"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="430"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="593"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="646"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1127"/>
            <end position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5496047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1190" mass="135299" checksum="6FE4C5EB86E4A4AF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN92</accession>
    <name>A0A9W9XN92_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1989 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795061.1">
        <property type="nucleotide sequence ID" value="XM_056930768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN92"/>
    <dbReference type="GeneID" id="81621017"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018959">
        <property type="entry name" value="DUF1989"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527:SF0">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09347">
        <property type="entry name" value="DUF1989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1989" evidence="1">
        <location>
            <begin position="45"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5496048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="307" mass="33639" checksum="29955F2D08EED66D" modified="2023-11-08" version="1">MSVARRPPPAYESSLAGIQATSAIYHRISRTASDATGRVLKESFEIPPCSGQAWTVPAGSVCRLTTPNGPQVGDLNLWNAHNPRERLWAARTRQIHASHVSVGDRLWSNLPYLRPLVSITGDSLGGGQLHDVLAPDGKRDPEKTFPSTQSGGRVHDLLGTRCDPYVNMLMGGKTFDFHCHSNLTRAVVPYGLTELDVHDVLNVFQVTGLDEEGRYFMEASPAQPGEYFEFFAEVDVLCALSACPGVPSTGDLSNWGWEDKEGDMLASCRPLGVEVYQLVDKDKVLEGWMQPQSPAYKGMHGMTMPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XND0</accession>
    <name>A0A9W9XND0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795121.1">
        <property type="nucleotide sequence ID" value="XM_056930828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XND0"/>
    <dbReference type="GeneID" id="81621077"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5496108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="71" mass="7538" checksum="62CD669B4A972848" modified="2023-11-08" version="1">MMMMMMDDDGGGGGDVSDDARRDDDDDRGDATSTWTGSSRASESELPEASVPHLISGFTVTQVLLGDAWDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XND2</accession>
    <name>A0A9W9XND2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_000540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794437.1">
        <property type="nucleotide sequence ID" value="XM_056930144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XND2"/>
    <dbReference type="GeneID" id="81620393"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052478">
        <property type="entry name" value="Metabolite_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="333"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
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            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="599"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5495424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="715" mass="76952" checksum="E83AB363A9E9A36C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ45</accession>
    <name>A0A9X0BJ45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785588.1">
        <property type="nucleotide sequence ID" value="XM_056939093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJ45"/>
    <dbReference type="GeneID" id="81629343"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5466542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8165" checksum="B959064C977AF7A9" modified="2023-11-08" version="1">MCYLFGRATKAVSVCPPAYYADLVCTRARCYMSDLFDPTPSTTPTGSVAGESDSRVSEVSQATVHPSIKDTMFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJB8</accession>
    <name>A0A9X0BJB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily domaingeneral substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_009018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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            <authorList>
                <person name="Petersen C."/>
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785990.1">
        <property type="nucleotide sequence ID" value="XM_056938613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJB8"/>
    <dbReference type="GeneID" id="81628863"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF5">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="361"/>
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        <source>
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    </evidence>
    <sequence length="484" mass="52230" checksum="EEA1ACE170F53EA7" modified="2023-11-08" version="1">MQQEPDHHDRRASGRSRVMTALTHALDELGLVTMYQSPRDVKFLCAQRFVRLFAYGGSTLILASYLSAIGVTDDRIGLFMTLTLVGDVVISFFLTLFADAMGRKAVLALGSALMAGSGVVFAMSGNYWVLLAAAVFGVISPSGNEIGPFRAVEESTLAHLSPKEKLPDIFAWYSLLGTAGTALGQLICGWLISSLQALHGWTFIPSCRVIFFVYAGVGLIKLVLTLALTHKVETEDKQRAREQRPTGETQPLLADASPAAQESSSPKNGKKSLFSSVEKDLWSLIIRLFILFGIDSFASGLASLSWMTYFFHRKFSLPEGELGTIFFVTSSISAASMLIASSIAKRIGNVKTMVFTHLPSAICLALISVPNSLPLALTFLVLRACSQNMDVAPRSAFLAAALPADKRTAIMGAVNVVKTTSQSLGPLLTGILARHNRFGVSFIIAGCLKVTYDLGMLASFAGKEAEARKQAAREETGDEEEEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJE7</accession>
    <name>A0A9X0BJE7_9EURO</name>
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        </submittedName>
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        <source>
            <strain evidence="3">IBT 30728</strain>
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    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </evidence>
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</entry>
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        </submittedName>
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    </gene>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
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    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="525" mass="55038" checksum="1BFCC0E217FB55D9" modified="2023-11-08" version="1"> </sequence>
</entry>
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    <accession>A0A9X0BJX9</accession>
    <name>A0A9X0BJX9_9EURO</name>
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        <recommendedName>
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        </recommendedName>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <topology evidence="4">Multi-pass membrane protein</topology>
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    </comment>
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        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
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        <location>
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    </feature>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367098"/>
        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
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            <dbReference type="EMBL" id="KAJ5469687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="227" mass="24309" checksum="3DF55FF908EA3F53" modified="2023-11-08" version="1">MVSLFGWGSSSSSNSSSQSDEPSLQRQGTSHQTHNGSVSSSSSSPPASLSSESSSTSISTSTSTMSTTISSLATRPQTPSTADNTNLKLFFGGMAFFALSVFVTRRASLRKRLACVPPYYSSSIYHQPNVNGAMEAFEALNLATLNVISFGMMATGGVMYALNINGVEDMRRIMRGTLDDVAAGKTDDELEKDVAEWVSSVLGDRFEKQLEKEKAKKRTAGQSVKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BLV6</accession>
    <name>A0A9X0BLV6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPaseAAA-typecore</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008684</name>
    </gene>
    <organism evidence="2 3">
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            <taxon>Eurotiomycetes</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786661.1">
        <property type="nucleotide sequence ID" value="XM_056938279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BLV6"/>
    <dbReference type="GeneID" id="81628529"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5472115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="236" mass="26758" checksum="EB26AFBBF5F6C59E" modified="2023-11-08" version="1">MIPTVPFDDVIDGKGQGFNILLNGPPGVGKTFTVEATSEYFKLPLYSISAGELVVDHGDSNALEQQLETVFKIAKHFNAVLLLDEADAFMEQRTSYHDTHNRLVTISLRKLEYYQGILFLTSNRGIQFDDAILSRIHFIIEYENLTREFRRDLWSTFLSKACTMQGPAVVEEHELRRLESLALNGREIKNIAAIAHALAEADVNQVNYKYLELAAESNRKISKEFGRERPADGMYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BLW8</accession>
    <name>A0A9X0BLW8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008613</name>
        <name evidence="2" type="ORF">N7539_008699</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786590.1">
        <property type="nucleotide sequence ID" value="XM_056938208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BLW8"/>
    <dbReference type="GeneID" id="81628458"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5472044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5472130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="96" mass="11046" checksum="08A4BCE0C2FFDB50" modified="2023-11-08" version="1">MAKRLGFRSDWIAKRGREEIDLLPRDRQAFPRDLCTGWKFHNNITRDDCLGQIGSGWLEKTETERQHLFSDIAETIGTDLSQSTLKSRAEKPQGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BM03</accession>
    <name>A0A9X0BM03_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786484.1">
        <property type="nucleotide sequence ID" value="XM_056938102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BM03"/>
    <dbReference type="GeneID" id="81628352"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="446" mass="49317" checksum="B271E621F3F5CD2A" modified="2023-11-08" version="1">MAKKSSKQRRTQEEHASPMSVQVSPKIDYVQPLSSPYEAPVVTATIGSKEYCIPGYCLRKCPQFEQQSFLYSYITLPGVHEDVGHTFVHFLYSGCYETINSSVEDGTSSVVREYKRSVLVYQASRTYQLPALEALARDYIERFGEEISMTDILRITKEVFSKLPNDETWLPKYIERNLRQSLRSSKSEFDLDELYNALGQDHYFDNTVTKMMLDILLHSQEITSQDGKSPCEQMHSHGNGEGNAAIDESVDKITNGRHTEESTNGNPASVKADAAHEPDAADEPDAADEPVAAYEPDAAHEPDVADEPDVADEPVAAYEPDAAHETDAAHEPDAAHEPDAAHEPDAAHEPDAAHEPDAAHEPDAAHEPDAAHEPDAAHEPDVSDEPDVAEDSPDKFRPPKVSLEDVALYQNWKSMSSRKRAKRTRTLVARGLPIPGEDGTVSIFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BMW7</accession>
    <name>A0A9X0BMW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Stress-associated endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_008126</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Interacts with target proteins during translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation and facilitate correct glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RAMP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786818.1">
        <property type="nucleotide sequence ID" value="XM_056937726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BMW7"/>
    <dbReference type="GeneID" id="81627976"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010580">
        <property type="entry name" value="ER_stress-assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06624">
        <property type="entry name" value="RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5475060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="97" mass="10669" checksum="000D2725573A08C3" modified="2023-11-08" version="1">MVSFLIPFTIIKINVTDSIQAQTPQQRRANEKFAKSEAAKRGRGPTVAKPKQSKSPVSTGWLVVLAFVVCGGLILELFRIVPQIWDTLASMLTRITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BMY1</accession>
    <name>A0A9X0BMY1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA processing factor 4 (PRP4)-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_008156</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
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        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="Proteomes" id="UP001148312">
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <begin position="111"/>
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    </feature>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="523" mass="57339" checksum="2DF243766CCCBD70" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
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            <authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786998.1">
        <property type="nucleotide sequence ID" value="XM_056937906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BN26"/>
    <dbReference type="GeneID" id="81628156"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5475240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="84" mass="9425" checksum="170C7893D10E4E74" modified="2023-11-08" version="1">MAHVCYEGGDGVSAFGGSVDIIALLGRSFKAYLGEPGRVEVTFFGQKQYLKLARRNHGSKPDEAWLAYHNPNNRRRCTHEDSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BN58</accession>
    <name>A0A9X0BN58_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone deacetylase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_008310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_056937910.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81628160"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="9">
        <location>
            <begin position="807"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="342"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="586"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1139"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1558"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="464"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="650"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1558"/>
            <end position="1571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5475244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1612" mass="180497" checksum="C1F73D381954F705" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNB0</accession>
    <name>A0A9X0BNB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786941.1">
        <property type="nucleotide sequence ID" value="XM_056937849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNB0"/>
    <dbReference type="GeneID" id="81628099"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="587" mass="64731" checksum="F726591F76C64FB3" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNG6</accession>
    <name>A0A9X0BNG6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787414.1">
        <property type="nucleotide sequence ID" value="XM_056937549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNG6"/>
    <dbReference type="GeneID" id="81627798"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="292" mass="33525" checksum="332493D8CC26E7BF" modified="2023-11-08" version="1">MEPRSLPNELIEAILRQVDMQTILLAQRVCRQWALCIRESSAIQEILFFRPAPANRPRQQNPLLAFKFPYWFPADDAGSCAIAFGAADMHHFLEISDIYRRPEASWRRMLVQQPPIMAMGWVERSVSPSDGRDLYRWEMPLQAFGGLKMNMLYDLVVNTSEFAPEYFYFRVLWSQSKTLSSSFASLHSEPCPSSFSDRISGPLRHAMQGADVVLDMWYAGQKNHLGKNQTWTRELVRGLKLAMEDFDIDLVCCMRELKEVKSWTLADELSDIAGEVEHGYPVPSPDEDDPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BPI5</accession>
    <name>A0A9X0BPI5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NifU-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788030.1">
        <property type="nucleotide sequence ID" value="XM_056937231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BPI5"/>
    <dbReference type="GeneID" id="81627480"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000001">
        <property type="entry name" value="NifU-like protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="2">
        <location>
            <begin position="87"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5477486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="322" mass="35330" checksum="33E34E797597F897" modified="2023-11-08" version="1">MTARATSTKLIRQAIGSTRTFRNSEICARNAATVTFSAYRSVSSAARLPILTASETRRRPTVRPYQQPIAQNGVNGMSPTSKRTIFIQTENTPNPDALKFIPNHRVLPEDFPTTFLEYLSPRSTLSPPHPSPLAAKLLDVEGVTSVFYGPDFITVTKSGDAQWAHIKPEVFSLITQAVTAGETIVTTTESENADGSQDGVSDSLSYNEDDDEVVSMIKELLETRIRPAIQEDGGDIELRGFEDGIVMLKLRGACRTCDSSTVTLKNGIESMLMHYIEEVKGVEQVMDPEEEISMHEFAKFEEKLRQQKGAAATASSPIDTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSA1</accession>
    <name>A0A9X0BSA1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_006622</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788158.1">
        <property type="nucleotide sequence ID" value="XM_056936223.1"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <source>
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        </source>
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    <sequence length="630" mass="69050" checksum="0DDCA9A12D110724" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="258" mass="29485" checksum="41F26401F7D04605" modified="2023-11-08" version="1">MPSKRKHSSVENVDDGNTENEQKRFAYLKSSVRRINENTIKSKWTTLPEPVQEKVRDLFLALERPVIVRQQNERKRIEAQSAVRAVVNNLSKRLPRMPFPPITKDSNFDYESAIDEHRSLEASLATMKDSADLLRAEIAKEESLLEQEKQSLQEMERNAKGAEAERKRSLKKEHPILRQLDNLQRPSFEECAQFAVLNHTQNSVTLDELDGDPDVHKLMLQLQGHLQSMQTNTAPLDGLSDAIMRSQAALDLLFTSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <subcellularLocation>
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            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RRM"/>
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    </dbReference>
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            <end position="307"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        <location>
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        <location>
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            <end position="196"/>
        </location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="451"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5485237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="465" mass="51705" checksum="6A8F8FF8353F6D37" modified="2023-11-08" version="1">MAPDKKGSKRKAAPVASDSPAKKTKKVEPKTTAAKPAKAVEEAPPKPAQKKKKETVTVKTKESKTEIVPKANGASTRQTKPRKRAADFLSDEETEKPAPAPTKAPVNKKSKKEESSTQTAKKSASAKIGKPTPKPKQIVEASDESDDEDFVLNASASESESNGSDQEIDDVEDDQTAALIKGFESSDDEDDVADEGYDSKQPIPRIPDTKKAEKKLKKLQQGENKDEPGTVYVGRIPHGFYEHQMRAYFSQFGEITKLRLSRNRLTGRSKHYAFIEFASSTVAKIVAETMDNYLMYSHILKCKFVPQDQLHPEVWKGANRRFKRTPWNQIERKRLLKGKTREEWSKRIDKEQRKRQAKAEKMKALGYEFDMPQLKAVEDVPVQVPEEPKAVESATAATEEKAEEQPLKAIEAPAPADEAPKKAKKGKKVEQTIVQEEVTAPSPATKSATTKTKKVVKKTTKKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUY7</accession>
    <name>A0A9X0BUY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790110.1">
        <property type="nucleotide sequence ID" value="XM_056934916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUY7"/>
    <dbReference type="GeneID" id="81625165"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF2">
        <property type="entry name" value="KETOREDUCTASE (KR) DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="124" mass="14229" checksum="7B62267CC805A9E1" modified="2023-11-08" version="1">MASMKNINPSSQTFFLQSDISLLKNVDKACAEIAPREQKVNLLFMTPGVMTMKGRQETAEGLDRKFVLHYYARMRFIYKLLPLLRRLHNRGPRVMALGYRGSSRYSTPWLRFVLAAQACLTSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BV98</accession>
    <name>A0A9X0BV98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790214.1">
        <property type="nucleotide sequence ID" value="XM_056935020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BV98"/>
    <dbReference type="GeneID" id="81625269"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="113" mass="11705" checksum="DE066ED70A075890" modified="2023-11-08" version="1">MAGGSARMESIDQCESTASPPLGASRAADGAEVEFVELGARRPRRVSVVDVRVLSGCTEARRQFAPGQEIEASVSNSPATTWGPRHGGAVPIGLGKVGKAAGGARRVCRRYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BVE7</accession>
    <name>A0A9X0BVE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_005568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790364.1">
        <property type="nucleotide sequence ID" value="XM_056935170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BVE7"/>
    <dbReference type="GeneID" id="81625419"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5485580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="193" mass="21200" checksum="F0289FEC5A6F4B3F" modified="2023-11-08" version="1">MLKTYETRNLTPSSGFVELTDGHLKLHPVPGFIILELRTKKPENVDHRVPPEARQIIETLCWVTSSALAADHTTPGSSRVKPDMFGFVKVPTFGRDLPPIIGYLAGTSSWRLASAVLRAIFAPAFCRPMNGSRDETAFRFVNTCSGLARVTDLELVSRNRENPTTRAEVSDGGLDVGLIPNEAISRGLWAIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY48</accession>
    <name>A0A9X0BY48_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NCS2</name>
        <name evidence="3" type="synonym">CTU2</name>
        <name evidence="4" type="ORF">N7539_003903</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BY48"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5489013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="367" mass="40347" checksum="8DCC5C0027AAFDF6" modified="2023-11-08" version="1">MPAKESQKICMDCKDADAILHTRHRHYCGACFKRFLSHKVAMRMSKFKQMKKSNGKAPKLLLPLSLGISSSVLLQIINEDIGRQFAKTFVNVGFEVHVLVVDAQGGANDDVYDAVSKAFSRLSFTKLPLHSVFEYVSEMGEIIAEYANQNFVDQEQATNEDRLTAFRTTISSPTSRSDLDSVLLTRLVVEYAKSLNCEAVIWGDSDTRLAAKTLASVAKGRGASLTWSVSDGMSPWGVNFDFPLRDLSKPELEQYLSVCEELSGLVVPDAPISEDVLTKNLSIDDLMMRYVRTQGEKYRGVMANVSRTANKLQSTIGSDDPSCPLCGGLVGNVKGNSGVTVANQSSDNYSAKFCYGCMRSRPESSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY68</accession>
    <name>A0A9X0BY68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho GDP-dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_003782</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790925.1">
        <property type="nucleotide sequence ID" value="XM_056933384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BY68"/>
    <dbReference type="GeneID" id="81623633"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000001">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00492">
        <property type="entry name" value="RHOGDI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5488892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="197" mass="22151" checksum="E275E4C3C76DFBCC" modified="2023-11-08" version="1">MADHHEDDLAAQRTEGFKVGEKKTLQEYQELDKDDEAMNRWKASLGLNSGEPIGQPTDPKCLIKSLAMVTAGRPDVVIDLSSPGAVDSLKNKPFTIKEGAKFHIKVVFQVNHEVLSGLKYIQVVKRKGIRVSKDQEMLGSYAPNTTHKPSYTKEFNEEEAPSGMLARGHYNAVSKFDDDDNNTHLLFEWSFDIAKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYN9</accession>
    <name>A0A9X0BYN9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_004473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791616.1">
        <property type="nucleotide sequence ID" value="XM_056934075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYN9"/>
    <dbReference type="GeneID" id="81624324"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5489583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="99" mass="11434" checksum="0EA2FF91FA1D56B3" modified="2023-11-08" version="1">MPEGIESDDLTNNAAKEIKFCDSFTHVWATRGYLGYFRQWYRGPTRPVETAHGIGIPSQFWFVAFSPLDPVERQWKLVRGQNRSTAKTRCWFSFAAFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ50</accession>
    <name>A0A9X0BZ50_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin and WLM domain-containing metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792273.1">
        <property type="nucleotide sequence ID" value="XM_056932314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ50"/>
    <dbReference type="GeneID" id="81622563"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795">
        <property type="entry name" value="UBIQUITIN AND WLM DOMAIN-CONTAINING METALLOPROTEASE SPCC1442.07C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="2">
        <location>
            <begin position="128"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5491144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="336" mass="37750" checksum="EC1D1FC2F6F2FD9E" modified="2023-11-08" version="1">MDITVHHQGAPHVFQVSDSATLQDLSTQIYETLNIPSENQKLLIAPKPGMQKAPFSSTPLSSLLPLNSPKFKITLLGSPAKAVADLHSQSESIRKRQEARASALAAARRSNNKPSASSRPSGIHTLSSSPSNSSYTFHRLLPLPYLPRPERSLQFLTRLRDDPGIRAAMIKHKFSVPLLTEMNPAEHTTSESRTLGLNRNKGEVIELRLRTDAYDGYRDYRTIRKTLCHELAHCVFGPHDRDFWDLTAQIEREVEQADWKMGGRRLTEEDFYDPGDWERVRGGEEVIDEQGWTGGEFVLGGLVNNGDRSLTRREVMAKAAEERMRKPDLNKTGEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ69</accession>
    <name>A0A9X0BZ69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_003037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792599.1">
        <property type="nucleotide sequence ID" value="XM_056932640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ69"/>
    <dbReference type="GeneID" id="81622889"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5491470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="92" mass="9847" checksum="02682E92E3C32AD0" modified="2023-11-08" version="1">MSVSATARRLTRGALSSSPMPTRQLTRFTISQRLSSSNAPKSSSSSSRPSPAPQNDRSQFKILPIVIIMAIGSGSYALLVKSRTGQAPQRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZR5</accession>
    <name>A0A9X0BZR5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_001578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793212.1">
        <property type="nucleotide sequence ID" value="XM_056931181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZR5"/>
    <dbReference type="GeneID" id="81621430"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5492832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="167" mass="17066" checksum="430CAB0B515CB7B9" modified="2023-11-08" version="1">MMSPISLKAIGGAAAVYLLGQQVQCPFVAIPLIGDAVAMTVAQVGSAAASFGGAIAAAHFGGGKRDIEGRATFVDAPAGVPQYNFDMCAESLADPSVHVTVTGPVQNNGVQIDGLPSTCMVLSNVFDGNAAGGPRPTPCGSACLLYNNLNQAEYSQMQAIFERMKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZY8</accession>
    <name>A0A9X0BZY8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_001507</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793141.1">
        <property type="nucleotide sequence ID" value="XM_056931110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZY8"/>
    <dbReference type="GeneID" id="81621359"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5492761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="344" mass="36728" checksum="19CFFEBA7EA47F07" modified="2023-11-08" version="1">MSSPAKGRRGGARGQGQSRDVQVSKALSLLLRHAAEKEGVKMNAQGYANVADVLQWRKLKSIQATFNEIKHAVDSSDKKRFALLHIPSAQPRPATVKATTTPTTIPGSTEPADGELAAGGDQPATAVVEAPSTDDDQTNATQQALASVDEDPSHYMIRATQGHTIQSVDAASFLEPLTLSDTSKLPDTVVHGTFHGAWPMILQSGGLRAMGRHHVHFATGPSLESVVAASGESTTEKGDTKQEKQVISGMRRDAQVLIYLDIKKALAAGCPFWRSENGVILSEGLPVSNAQIDGEGNTEKVVSSEFFDVVVERKAGLGKIWERGAVIKALPETLTKKGTPKNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C049</accession>
    <name>A0A9X0C049_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-erythronate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_001687</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793321.1">
        <property type="nucleotide sequence ID" value="XM_056931290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C049"/>
    <dbReference type="GeneID" id="81621539"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05238">
        <property type="entry name" value="Gne_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF3">
        <property type="entry name" value="ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5492941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="317" mass="34561" checksum="2E3E9F3BE3309685" modified="2023-11-08" version="1">MQILITGAAGFVGQLLAKELLNDPAYQVTLTDIVQPPVPKGALHPQNATCIKADLLKAAQDVISPSLDAVYAFHGIMSSGSEANFELGMSVNIDATRNLLEALRKTCPGVRVIYSSSQAVYGQPLPDIVTDSVIPTPESSYGAEKIVCETLINDYTRRKFITGFTLRFPTISVRPGAPTAAASSFLSGMIREPLNGKECLIPIEDRSFKSWLCSPKTLVQNLLLTLQLPGDSVPPHIRQINVPGICVTVQEMMDALKTVGGQDKLKLLSEKEDPTVVPILRSWPTRFDNSQAISLGFKRDESFEQTVRDYKASLEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0F3</accession>
    <name>A0A9X0C0F3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793425.1">
        <property type="nucleotide sequence ID" value="XM_056931394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0F3"/>
    <dbReference type="GeneID" id="81621643"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="5"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="244" mass="26861" checksum="ED8D6C23E3F6C5CC" modified="2023-11-08" version="1">MPQKHRILALVFHEFENLDLFGPMGAIIPGSDYYTLELVNVHNLPSPNGLESSIKNGIGIMPNMTLTQALEDTKPFSTLFIPGGLSMMHFLEDAILLEKIGQLVLRAPTVFTVCTGSLILAATGVLDGRGATCNKQLFDEVTPKYPRVIWKKKARWVTDGKYLTASGVTAGIDAGFAFVARTYVAPEDRDDRPEIIAEGQGDNESFARNYDSEKAIKYARHVARMVEHCWNEDPGNDPFAVTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0R4</accession>
    <name>A0A9X0C0R4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793770.1">
        <property type="nucleotide sequence ID" value="XM_056931739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0R4"/>
    <dbReference type="GeneID" id="81621988"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052254">
        <property type="entry name" value="CUL4-DDB1_E3_ligase_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472:SF1">
        <property type="entry name" value="DDB1 AND CUL4 ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5493390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="427" mass="48169" checksum="EDB55403A756649F" modified="2023-11-08" version="1">MNVEIPGFYYDPEKKKYFKIQANHVAPPGAQYSKESVKRKRNEHQASLAGFQPRSPMAKYAVLAANILQEQEKRAKVNQRLERETVRKPSLLHHPLMAVERELGSRWSSTAVMKERQARVYVSQLKRRKLHKFEPWPSPFNIRHVLRNPRSGALITTTLDSGPDGDSFLAPRLLPNPDEGGDYRWPSEFHHPLKIHLPQTLWCSAACPVGDKALFAIGTSDGLHTLEGLTSMWTVSQKPFRKDDSNGARGFRRHGNSSHASVQAVEWISPDVVVSGLRNSNVFLYDVRNGESSLRLQHSQSVTKIRKADPWRIVVGGHNTVCDGYLFKLRTSSHPAHAPSMQVEMYDLRYVAKCLHSKPKPMSGSHNSTRPYLSFKDFTPEEIPDLDVSSELGLLACGKIYTLPFSLLHNTSLVQYVSNARCDNSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0V9</accession>
    <name>A0A9X0C0V9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_002120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793754.1">
        <property type="nucleotide sequence ID" value="XM_056931723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0V9"/>
    <dbReference type="GeneID" id="81621972"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000118">
        <property type="entry name" value="Phosphatase 2C-like domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF24">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="133"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5493374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="414" mass="45776" checksum="464772B6794C29CA" modified="2023-11-08" version="1">MVITVGSVPPSHLSSFPRLTRRWIVGNVTGASVSGLLCRRASRLCDPIHLARSLVHQPSRRLFHTAVWPSYGVTTPSPDRQRAGPAPSPFRFETGYAFCAKRPPRPFPPPFLSPPSSSFSDPLTTHSLSQDKRLSVRGEPIRGLTNGDDAILAAETFLGVDDGVGAWATKPHGHAALWSRLLLHFWSLEVERFVSENDTALDPIQYLQTAYEQTILATEKPTKWLGTTTSATAILHFTGDEGSSLQPLLYVTNLGDCKVLVIRPSEDKVIFRTAEQWHWFDCPMQLGTNSVDTPRKDAVLSEVPLQENDIVLVVSDGVMDNLWEHEVLKIVMDSTKKWDESRCKNQNVSPTSDLADPRMVYTARELLNAALNIARDPFAESPFMEKAVDEGLAIEGGKMDDISVVIASCHRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C3C5</accession>
    <name>A0A9X0C3C5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794997.1">
        <property type="nucleotide sequence ID" value="XM_056930704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C3C5"/>
    <dbReference type="GeneID" id="81620953"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22189">
        <property type="entry name" value="PGAP4-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029675">
        <property type="entry name" value="PGAP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410:SF1">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="279" mass="31988" checksum="EBF62F09DA4DE491" modified="2023-11-08" version="1">MTAQVWYMVPEIGAWLTTGLFLFSDYVYALQTCKDLNASHTIIFEDDIILATGWFSKTLKALAEIARFEQHSAKPWLYLRLFYTETSLTWTSSDFVYRNMPFVFGFLMLSTVSCLIALRRSRYQRFHLDTASIAVISVVCVPAFTAFIYMVGKYNLMPLTGVVEMNKYGCCTQGLVFPRERVNGLMQFLRERGHGQTDSMIEEYADSHELTRYALAPPQLQHVGLKSSRDNTDVNTQSTWAFWFETNDATSLKKEHQMLLQDEDVKGMLWNVTDSGSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKE3</accession>
    <name>A0A9W9WKE3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">CTP synthase</fullName>
            <ecNumber evidence="3 12">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_009408</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="3 12"/>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785725.1">
        <property type="nucleotide sequence ID" value="XM_056939003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKE3"/>
    <dbReference type="GeneID" id="81629253"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000005">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="14">
        <location>
            <begin position="2"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="13">
        <location>
            <begin position="315"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5466679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="577" mass="63586" checksum="AB919D8941B6AC8A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKF5</accession>
    <name>A0A9W9WKF5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_009384</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785701.1">
        <property type="nucleotide sequence ID" value="XM_056938979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKF5"/>
    <dbReference type="GeneID" id="81629229"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF55">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="549"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="302"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5466655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="580" mass="62481" checksum="A1E04B01F7FD1AAE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKT1</accession>
    <name>A0A9W9WKT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 11">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_009507</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 11"/>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785597.1">
        <property type="nucleotide sequence ID" value="XM_056939102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKT1"/>
    <dbReference type="GeneID" id="81629352"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040869384" description="endo-1,4-beta-xylanase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="15">
        <location>
            <begin position="31"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="14">
        <location>
            <begin position="242"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5466551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="277" mass="28648" checksum="5516B8F85DBDB75C" modified="2023-11-08" version="1">MLSFTTAFVAAAVAAGVVASPAASPAALSRRNTPNGQGTNNGFFYQFWDDGSSGVTTYTNGAAGEYSVNWQNVGDFTAGKGWSNAQPRTINFSGSVSASGNFYLAVYTWSTQGENYILEDYGSYNPCSAGTSKGTLHSDGSDYEVCLVNRGNNYLQNWSVRKNKRSSGTVTTANHYNYYQAQGMTHNPLSAAAYQIVSTEGFGSSGSAKITVSEASGSSTGSTGGSGSSTTTTASSAPTTGTCAQIWGQCGGSGWNGPTCCASGTCKVTNAWYSQCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKU5</accession>
    <name>A0A9W9WKU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785926.1">
        <property type="nucleotide sequence ID" value="XM_056938549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKU5"/>
    <dbReference type="GeneID" id="81628799"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5469336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="406" mass="46246" checksum="361C2754C4BFC90D" modified="2023-11-08" version="1">MDLEDISQWLSTGKPPQTPLVMLFSQYLNAEEAAQIFQRFQSEDWIPNGQVLWSGVPRDKAQKWADNHHLQTLTTAMGPLMDKEHPESLKSKMTPHHWIQYVRGASAVFAWHIARGEKVTVLLPPPPERFHPSGLTNYQAIEEPIVRGQIGQYAVRKIVLVHPTVTESEEYFYEGWPEDEYSTWIQKYGLRNKKITWRKIGRSGDKLRLKTLMARPKLYPLAEPIDWVEKTETPREYSASLSLSTGPHHIKSGTGQAALVAALSMFFVLLSSKFALLALMGVSYVLIDETLRGSEVNQSCRLQANSKAGQEVNCVKGANNFLETISDRVEFKTQEESKTKLKDWKKVQAKAQKEVKNIEVERKAQVKAQEEAKRKELKDELKAQAKAEKKAKAESKLPDKALKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL22</accession>
    <name>A0A9W9WL22_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fructose-2,6-bisphosphate 2-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_009416</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.46" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785733.1">
        <property type="nucleotide sequence ID" value="XM_056939011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL22"/>
    <dbReference type="GeneID" id="81629261"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000005">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="9">
        <location>
            <begin position="9"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="229"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
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        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5466687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="451" mass="51419" checksum="3EEA2EA351073E55" modified="2023-11-08" version="1">MSPAYLGFQSEDYKICVVMVGLPARGKSLIAGKAMRYLAWVGIPAKVFNVGSYRRHATPQPAATFFDPHNEEGERMRRAAAEAAMTDMLQWFQDGKGVVAVLDATNSTKERRKWIYETCHKADIETLFVESICDDEDLIMNNILEVKTTSPDYKGQDPELAALDFRNRIRNYELVYQTIDDDEKSFTYVKLINVGSTVIINQIKDYLSSRLVYYIQNLHIKPRSIWLSRHGESEFNLSGKIGGDANISERGEAYARKLPELLRQSGVPENTKIVIWTSTLKRTIQTARHLKAETGYEKLEWKALDELDSGVCDGLTYEEIAEKYPEDFAARDEDKYNYRYRGGESYRDVVIRLEPIIMELERSENVIIVTHQAVLRCIYAYFMNVPQEQSPWMEVPLHTLIKLTPRAYGTEELRFKANIPAVSTWRGKGSSAKHQDFPAEGSEPASTAGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL40</accession>
    <name>A0A9W9WL40_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin NUP37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="81628963"/>
    <dbReference type="Proteomes" id="UP001148312">
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    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5469500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="656" mass="71485" checksum="016EFD3DD95239BA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLH2</accession>
    <name>A0A9W9WLH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_009249</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786221.1">
        <property type="nucleotide sequence ID" value="XM_056938844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLH2"/>
    <dbReference type="GeneID" id="81629094"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="40S ribosomal protein S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uS10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5469631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="116" mass="13080" checksum="78B303305233EC9D" modified="2023-11-08" version="1">MSFQKPEKEFGEGPKVHKIRITLTSRKVASLEKVCQELIDRARSKSLQVKGPVRLPTKTLTISTRKTPNGEGSKTWDKYEMRIHKRLIDLLAPTETVKQIIINIEAGVEVEVTIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLJ5</accession>
    <name>A0A9W9WLJ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_009296</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786268.1">
        <property type="nucleotide sequence ID" value="XM_056938891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLJ5"/>
    <dbReference type="GeneID" id="81629141"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF130">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTO (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="160"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5469678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="774" mass="87135" checksum="D42C191873033CE2" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQP4</accession>
    <name>A0A9W9WQP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786477.1">
        <property type="nucleotide sequence ID" value="XM_056938095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQP4"/>
    <dbReference type="GeneID" id="81628345"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5471931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="55408" checksum="4CB313BC3B4A3D86" modified="2023-11-08" version="1">MSSPLYRGDHADFAHHLSLLKLEESDGQSDEVLLAPVLTGPVLNQPSLDPTQYGLLGGVKKIDTPIYSTMDDELTKKDPRLFFNVSSPSSVFICGSQGSGKSHTLSCLLEGCLIPSKAGRLLSPLTAVVFHYDAFICDGGGSPCEAAFLSSHPNLKVRVLCAPTNLRTIKVRGASINKAHIAYNATGFNIDVQPLQIDQSHLNTKRMLDLMSVARNSSAGPLYLQTVQRILREMRLLQQSTGCPFNYQDFKSRVLGSGLLTSQMEPLKQRLDILESFMPPNQARTDYNVKGTKAKPHDGGSIWVPKLTIVDLSCPCVSPDTACSLFNVCFGIFMEQDTRIGRIVALDEAHKYMKDSVEAQNFTDTLLSTVRLQRHLGARIFISTQEPTISSDLLDLCSVAIVHRFSSPAWVRALQSHVAAAALNLHAAKDSLAKDEQALLDIPTRLSIFHRIVNLKVGEALLFSPGAMLSIVSKEAEQEMVRLGSGYMTIKVRGRLTEDGGKSVLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WR42</accession>
    <name>A0A9W9WR42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786517.1">
        <property type="nucleotide sequence ID" value="XM_056938135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WR42"/>
    <dbReference type="GeneID" id="81628385"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5471971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="150" mass="17444" checksum="9F8914427488E72D" modified="2023-11-08" version="1">MEPSLIKPGALSASGLDAKELAEYKDLLYFLKEERSFKHSLSKPMARIPSKTKDWLAPEWHGILADVTCPSRQLVRLKQQFAPKKNTRVQDLRTDWRKMVDIPYGRTSLERWLLNWSNMHDDAKAAKVPDVCYTDAEYPPDSILHSRYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WRD9</accession>
    <name>A0A9W9WRD9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_008690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786667.1">
        <property type="nucleotide sequence ID" value="XM_056938285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WRD9"/>
    <dbReference type="GeneID" id="81628535"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5472121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="170" mass="19037" checksum="B0F5D953C6372C87" modified="2023-11-08" version="1">MRDYMPGSHRRFLQDVEAVANIRSYVDDRRTGFALQFAYDTCLSMLREMRDQHIQVVCRYIVVQSRVNQQAPPSGTHPMVIDSATMVPGDRKILRGTGGTALIPFLKQARDETAEPVIDARARRLLSHKPGSLEPASLNKVGEQPDDHPQLVDPCGKWTAGHSEGGICRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WRL7</accession>
    <name>A0A9W9WRL7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786538.1">
        <property type="nucleotide sequence ID" value="XM_056938156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WRL7"/>
    <dbReference type="GeneID" id="81628406"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5471992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27942" checksum="AAA95FFF7D03AEF2" modified="2023-11-08" version="1">MACINYDNGAVSCKNPTTAENPASSSECIAVTAERAYYRCDRFFIKRSLRPSEFQTGYKGLHIPRLGKERLRNEAESLRFIRHSSNIPVPTVYGAFEVDDAFFLITDFVDGVAMSRLSEDDKKIVMEELDQHRATLQQMRSHNIGGPSGILIPPYRIMRHTTNDMWPTCPSETSEYVFCHNDLSQQNIIVDPHSLKINAIIDWEYAGFFPKYFEFPFYKRLGPSIAVDGEQDDVPKLLQFLAEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTL8</accession>
    <name>A0A9W9WTL8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Dehydrogenase patE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_008377</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787069.1">
        <property type="nucleotide sequence ID" value="XM_056937977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTL8"/>
    <dbReference type="GeneID" id="81628227"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="578"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="622"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="623"/>
            <end position="624"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5475311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="646" mass="71289" checksum="966B54D607938ADE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU92</accession>
    <name>A0A9W9WU92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UPF0442 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_007916</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787382.1">
        <property type="nucleotide sequence ID" value="XM_056937517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WU92"/>
    <dbReference type="GeneID" id="81627766"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="618"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="661"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="686"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="710"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="736"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="807"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="8">
        <location>
            <begin position="393"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="9">
        <location>
            <begin position="667"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="234"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="332"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5475629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="842" mass="91676" checksum="09F15876B888E980" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU97</accession>
    <name>A0A9W9WU97_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787146.1">
        <property type="nucleotide sequence ID" value="XM_056938054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WU97"/>
    <dbReference type="GeneID" id="81628304"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5475388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="61" mass="7118" checksum="833E61B950CC058C" modified="2023-11-08" version="1">MDAFVPSDLDYGHLQPERSSWLKAGHKTRQALREDGPFWISRNGWILDIEHELAKPSRDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUJ3</accession>
    <name>A0A9W9WUJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Maltose permease MAL31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_008423</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787115.1">
        <property type="nucleotide sequence ID" value="XM_056938023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUJ3"/>
    <dbReference type="GeneID" id="81628273"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="53"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5475357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="548" mass="60865" checksum="818B623DE9296607" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV19</accession>
    <name>A0A9W9WV19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_007899</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787365.1">
        <property type="nucleotide sequence ID" value="XM_056937500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV19"/>
    <dbReference type="GeneID" id="81627749"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5475612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="654" mass="74825" checksum="4EBB9EFFF3051278" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV29</accession>
    <name>A0A9W9WV29_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Multifunctional methyltransferase subunit trm112</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eRF1 methyltransferase subunit trm112</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_007414</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRM112 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787814.1">
        <property type="nucleotide sequence ID" value="XM_056937015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV29"/>
    <dbReference type="GeneID" id="81627264"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000021">
        <property type="entry name" value="Multifunctional methyltransferase subunit trm112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5477270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="126" mass="14044" checksum="48A92594667008C8" modified="2023-11-08" version="1">MKVITANFVTCAVKECKTSAASFPLHFQDAELEQLELDLQPEFIRNVLPRVDWDSLRITATELGFPALPETKPEGDALNDEQTLKDLHRLLLETSVVEGKLVCGNCGHQYVIKEGIANFLLPSHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV59</accession>
    <name>A0A9W9WV59_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein kinase SCH9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787674.1">
        <property type="nucleotide sequence ID" value="XM_056936875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV59"/>
    <dbReference type="GeneID" id="81627124"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="489" mass="51948" checksum="FB9B2DB7FCC60B39" modified="2023-11-08" version="1">MASTLEMPVTSCKFIDMIIYPTIANPPPPTINRSGLEDDISDQIGSNGSTPTGVATPQPDPADKRLPSIMHNYFQVGSSSGDKSSLPRFWSYLSRPSSVDPSPSHALPETSPDTSAAMTATATASLPATTTCDSDTASESPVSMEQNYGEERKQSEALPMANPPTPPHSLLQTEPDEMDLGSSLDHSDGSSLLHMLKKYLAPPASSTPPSRRQTSLPVSSVSDDPVLATHFSNPSVPSASSSLPSPPDDLATAAAAPGLATGDLYTPSAAPLLGHELPPVSVSSENLAKLTQNAPDVARLKNTPPLTPRAMSNEDESANIKATEPAPRADESEESPVSEIPAAEQPTPTDSMDSSADEIAEKLDEAFPRRSSSVPQNGAPVGPIKGKLIVKITEARGLRPSFDPYVVCVFEWNEYISKGARSGEEEKKRRQMQSDADARVSMAIPMKSRQSSYNSAVEGQDHKGRTAVTDPHWDHEAVLRPIRGGRDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV90</accession>
    <name>A0A9W9WV90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_007504</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787904.1">
        <property type="nucleotide sequence ID" value="XM_056937105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV90"/>
    <dbReference type="GeneID" id="81627354"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5477360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="413" mass="45170" checksum="E95E0C96AE245682" modified="2023-11-08" version="1">MASIQLPLVLTKLAYLIDNPWNVSLARANAAGLVLADSLQDRNLGNRPVTLLGFSLGARVIFSCLKELASKGAHGLIQNVYLFGSPVVASKDEYLKARSVISGRFVNGYSKNDWILGYLFRATSGGIMRVSGLAPIEGIPGLENVDLTDTVNGHMDYRAAMPRILRRVGWEVLDDEFAEIEDPDPDNHAERQRELIREIDEARRTAEQKPEKKRFGLFKRGKMAEKKTWETYDVNRSAAGQQHSADPVSAPGSVLFDIEAIRAELASEAIEVKQLESTLPPMKLDLNRSLDASPSQSVTSLGKDPSPKGSMPPPLPRTVSEPIPTGSRSARTTSYDDHSNDHDSTQMTFDTSFHDSSKRSADPPSRPSLRTSATVAAGIGATAVGAIAMEPNAWADHDHDSYHEESEISMTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVH2</accession>
    <name>A0A9W9WVH2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="3 9">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_007439</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="9">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IPK1 type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="3 9"/>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787839.1">
        <property type="nucleotide sequence ID" value="XM_056937040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVH2"/>
    <dbReference type="GeneID" id="81627289"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5477295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="351" mass="39412" checksum="918313BD0D970D82" modified="2023-11-08" version="1">MARLGIPDLPSGIKLVYLAEGAANVVYRFDLTEAFIPGPTNRPDLPDTDDTTVHEAPGLLQGKLLRLRKDTPANVPYKEIEQNFDTIIRPLFKLHELVNQSLIRLPPGLIHHCNERLRAAEESGSRAFKRHGTYLSLTEPYGLLITDMTTYNDPGAHLAELKPKWLLQSPSAPADADRCRTCALKQMRDAEARSRGQEEQRSFCPLSLVSEKFEIVLRATEYVKGCWDKTRLAEILFRHPVLLRLLSLQKVHQRVGLEGPPPKTQVMSLDMTLRDCTVYIKIPQDEGSQVEVRLGDLDLKSSAGGKAQYWRDLETDLIEGGWYHGRDEDATNDHGCLLQHSKVPAALALLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVW0</accession>
    <name>A0A9W9WVW0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNAse III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_007385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787785.1">
        <property type="nucleotide sequence ID" value="XM_056936986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVW0"/>
    <dbReference type="GeneID" id="81627235"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5477241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="141" mass="15278" checksum="846BBA059CC4AFAD" modified="2023-11-08" version="1">MPRHRPSATREAHPAKAQQILGYHFHKPSTLHKALSADKSLALHGDALIQHILVKEGLHRHASRGRINQVLKTASNAHLSQRGYSTGLAACIRVTPGQNGCPQPGPVADAMEAVLAAIYEDSAENMGAVESVMKRLGIWWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1X9</accession>
    <name>A0A9W9X1X9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribophorin II C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_006639</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788175.1">
        <property type="nucleotide sequence ID" value="XM_056936240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1X9"/>
    <dbReference type="GeneID" id="81626489"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044333526" description="Ribophorin II C-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="23"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="9">
        <location>
            <begin position="181"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5480745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="289" mass="31204" checksum="E5CFEAEFE1F072CE" modified="2023-11-08" version="1">MHLWQATLPICLLVSVALPVAATSAWGFADATVAVQPKGAGINGGFKEQFDSKKPLSKPIAFTDVDSLRVILTAKEGSSSKRPHQAFLLLKDEKNGLDVSYPFTVKENGKARLELTQKELPIQFLSLTDPIDARVVIGSFGESKAYDSSVFKLKIQRDANVPLPTAVTSRYGKLPEIHHIFKDSPSNPPIVITLAFTAAVAATLSVLGFMWLFLGANLGHLPTAIKNAPLPHAIFLGSLFSFEGLFFLYYTSWNLFQLLPAAAVVGVVAFVSGSRALGEVQGRRLAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X277</accession>
    <name>A0A9W9X277_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH:ubiquinone oxidoreductase kD subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788448.1">
        <property type="nucleotide sequence ID" value="XM_056936513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X277"/>
    <dbReference type="GeneID" id="81626762"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008699">
        <property type="entry name" value="NDUFB8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05821">
        <property type="entry name" value="NDUF_B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5481018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17542" checksum="D1360CD913186AA0" modified="2023-11-08" version="1">MLSQRILARRLPQVVARSTIAPRASFSQIPALRAADVEDPFQNGNYQNPPRVKRQFRDPYGGWWDKQEKRNFGEPVHEDNEILGVFSPEQYSHVSSRKAFRHLGVFVATFLTLCGVVSLYYPDKPSAPKVYVDGLEKELGGPNAVPARKSGEDKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2C4</accession>
    <name>A0A9W9X2C4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_007052</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788588.1">
        <property type="nucleotide sequence ID" value="XM_056936653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2C4"/>
    <dbReference type="GeneID" id="81626902"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF314">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5481158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="415" mass="45794" checksum="217148913D9C5155" modified="2023-11-08" version="1">MPPFRIVIVGGGIAGLTAAIALRGPNRQITVLEQSRLNKEIGALISLQPNASRIVEQTWGLKKELAAARSMVDEGFRIYNTDGALVNSVPLSTTAEYGAERLCFHRRDFHDQLKEAALSTERAGEPVILRTASRVVDCDPEAGSVTLEDGGVLSADFIVAADGIHSVIRKHVLQEEPSPLPTGHSGEFFFECIRSEILEKEEPDFCSKINPRDPYTSMMVAHNCRLVMGPGRQGEVFGIVALVPDEQMNEDPSAKQSWVAEGNLEKMLDTFSEFPKWMTGIFKHSSDLGLWQLRDLDPLKTWHRGRVMLIGDAAHAMLPTQGQGASQAIEDSEALGAYFEGITEPPSAEILSQTMENIFQARYSRVSLIQAYSREAAKPAAEKKTVTLRPDEFMKFNCMYKGAKAWSNQQIPTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2G8</accession>
    <name>A0A9W9X2G8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Sulfate transporter family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_006128</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788654.1">
        <property type="nucleotide sequence ID" value="XM_056935730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2G8"/>
    <dbReference type="GeneID" id="81625979"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000141">
        <property type="entry name" value="Sulfate transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000012">
        <property type="entry name" value="Sulfate transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310:SF4">
        <property type="entry name" value="AFR304WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="618"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="671"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="11">
        <location>
            <begin position="742"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="971"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5482682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1085" mass="118707" checksum="EDE7620A0F1D950A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2Y9</accession>
    <name>A0A9W9X2Y9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_006428</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788954.1">
        <property type="nucleotide sequence ID" value="XM_056936030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2Y9"/>
    <dbReference type="GeneID" id="81626279"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="598"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="9">
        <location>
            <begin position="214"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="11">
        <location>
            <begin position="302"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="10">
        <location>
            <begin position="406"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5482982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="631" mass="69496" checksum="92D9BE03A39483A1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X351</accession>
    <name>A0A9W9X351_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phenazine biosynthesis-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788361.1">
        <property type="nucleotide sequence ID" value="XM_056936426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X351"/>
    <dbReference type="GeneID" id="81626675"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF32">
        <property type="entry name" value="ANTISENSE-ENHANCING SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5480931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="36182" checksum="06605DEC8704B95A" modified="2023-11-08" version="1">MLQLKYLTLDVFTTQPFQGNPLAVVFLPSDPQHTLTQRQKHLLCLEFNLSETIFVHPVTDPNNSPHRTIDIFTIECEIPFAGHPTIGAASWFLVHGQQDPHHPVTSLITKSGEIPISVQDAQTGAVAARIAHNTRIHAQRFPLAELLALHPTVRPYLNESESKDFPLFSIVNGMSQLFIELPSLEALAAVTRPTGAQLIPTEKYLDAGWQSGLICVYFYVRDVEDEKMGGKVIRTRMMLSGIEDPATGSSASGLAAYLALTEGEGRGKQQSQEGGDGQIRYHFVQGVEMGRRSDIGVNVRMEGGFIQQVELTGTAVRVSEGVVAVPEVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X4L1</accession>
    <name>A0A9W9X4L1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000007">
        <property type="protein sequence ID" value="KAJ5483837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789107.1">
        <property type="nucleotide sequence ID" value="XM_056935639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X4L1"/>
    <dbReference type="GeneID" id="81625888"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
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    <sequence length="540" mass="60768" checksum="B13BBAE98DA063AE" modified="2023-11-08" version="1"> </sequence>
</entry>
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        </source>
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    <sequence length="155" mass="16204" checksum="50D5A0C4454AA839" modified="2023-11-08" version="1">MYFTPAIVSALSLASLCTEAVVEKRKSWLFSCGCDSQSDANVNPMNAVKVVHTGPLSSVSVMYQSGNCGLAIGNLQNINGPGGVGGGVSGTTISGADFKDLMTLMLGCHDSAKGLVNVCPSVGAGNAMMMKAEGIILLSSSRRKIHREWRLVYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        </source>
    </evidence>
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</entry>
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            <end position="538"/>
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    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5485345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1129" mass="122296" checksum="58A06EEE82F350B1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6P9</accession>
    <name>A0A9W9X6P9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF567 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790148.1">
        <property type="nucleotide sequence ID" value="XM_056934954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6P9"/>
    <dbReference type="GeneID" id="81625203"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087:SF161">
        <property type="entry name" value="TUBBY C 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22368" checksum="D06CF86814586F2F" modified="2023-11-08" version="1">MTDHGRYALAPIAEPLAIHAEYIKPETSVIQMKEKIMSLSGDSFEVTLARGHPLLKVEGKWVTISGRKKVSDAVTGTHLFDIVKEHLHLHTTYALEDPKGKKIAEVKSALKLMGSKATATFTDVRGRNVTLKMKGGWFDHSADIVEERSGQPVARIDRKMINSRDLIFGQQTYNVVVAPGVDVALIAALCICFDEKNNETQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6R4</accession>
    <name>A0A9W9X6R4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arsenate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789890.1">
        <property type="nucleotide sequence ID" value="XM_056934696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6R4"/>
    <dbReference type="GeneID" id="81624945"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000050">
        <property type="entry name" value="Dual specificity phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF38">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="26"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="141" mass="16080" checksum="CF8AABABBED37308" modified="2023-11-08" version="1">MSSISIATLPRMSRDALSALLRSKTPADKLAIVDVRDSDHIGGHIKLSTWVPSSSLDVRLPELLRTLKDMDKVVFHCALSQQRGPSAALRYARERERTLGEEESKKQEIYILEGGFVQWQEKYGDDEQLTEAYVADIWREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6Z3</accession>
    <name>A0A9W9X6Z3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_005502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790298.1">
        <property type="nucleotide sequence ID" value="XM_056935104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6Z3"/>
    <dbReference type="GeneID" id="81625353"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5485514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="268" mass="31015" checksum="B1D470F078730B03" modified="2023-11-08" version="1">MQAVRAHELAIQRIIDGLGGLIIWDMILSPFYTCDLMRGLTSDMPLPLHESWKWELKVRTECLFLHEEYKVSSTSFVGRRFFNSPWSASLHPQLVSTLRSLRKLVSLYESVVSSSWGQTRMDNDGLLLLDHELLYLAQDQSLPAFQDTLRLTALIYTVVRIRGFSGMPCADIFVNTLRKSLENSLKFLDANAPDLLLWIFFIGSLASRDRRHHAWFSRRLQVLASTLGLEQWDSAMIVMQEYLYVCRPTDGFVREMWETAFEEKVVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCM2</accession>
    <name>A0A9W9XCM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790840.1">
        <property type="nucleotide sequence ID" value="XM_056933299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCM2"/>
    <dbReference type="GeneID" id="81623548"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="103" mass="11340" checksum="343B4B8F80AF3101" modified="2023-11-08" version="1">MSYSSNQLFKAARVQRRHSITEGAYICLRASPLRSGQGIKLLFQASHILFEAFFSLIIIIVIGETAALAGSALHVQPIFNAGAAHRHSYNNAGRLPRSAREYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCW8</accession>
    <name>A0A9W9XCW8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791113.1">
        <property type="nucleotide sequence ID" value="XM_056933572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCW8"/>
    <dbReference type="GeneID" id="81623821"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5489080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="134" mass="14444" checksum="C1ABF3EA262DA3DB" modified="2023-11-08" version="1">MIAGSQSRGTERAESRANGHAKFCIGIPTLPSKRDHIRVDVDDLLEWVTWDGGGLGDPLTCPAGKVALEVHRKLVTADGAREGYGVVANSDFTANQTLTEESRAQMHQDRAQLGEISVDERGGSIDELRKSCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XD69</accession>
    <name>A0A9W9XD69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">GPI-anchored CFEM domain protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">N7539_003462</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790605.1">
        <property type="nucleotide sequence ID" value="XM_056933064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XD69"/>
    <dbReference type="GeneID" id="81623313"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040864759" evidence="17">
        <location>
            <begin position="19"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ5488572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="228" mass="22290" checksum="07591E0C96029232" modified="2023-11-08" version="1">MKFSATLIALVAAGVAHAQLPNVPACSVCDTPPFPRYTADLNCFVTALTTDGCSSLTDFACHCSKPQLVSTITPCVQKACKVPDQISVSNAVVAQCSSAGHPIVVPPIETASSAASSAASTAAATTSAVAQETTTSAAEQTTVPMASSSSTSSVVMTAVTTTGWAVSTPVKSSTAMASSSHPAGSSKPTPTSSGAAAATTSPAYNAAGSIKGNMAGVAVVAAAAAYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XD75</accession>
    <name>A0A9W9XD75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB/POZ protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791204.1">
        <property type="nucleotide sequence ID" value="XM_056933663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XD75"/>
    <dbReference type="GeneID" id="81623912"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="18"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="277" mass="31573" checksum="F2FCAFE44FCEE882" modified="2023-11-08" version="1">MSELKDVMRDLLLRGRFSDMEILCQGITFKVHQAIVCTQSSYFYSAMCDGFKESIEKAINIEDDTPETMERVLSFLYLREYSEDGRIIQYQQPISALPICDHESGSSLSENKPEISEPANQAAFNNIEVFIAADKYAILPLKTLATLKFSRWANTNCSSPMFHEVVQKVMTSVPPHESTLREVIADIISRHVFDLIKDPEIVHNLDSFGCLGSLVIARLVSNEMVKRPNEYDVLRALVQKINSSRRCRHCAKDFNVRLISGEYLDENFRCASCNTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDA6</accession>
    <name>A0A9W9XDA6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_003643</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790786.1">
        <property type="nucleotide sequence ID" value="XM_056933245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDA6"/>
    <dbReference type="GeneID" id="81623494"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000076">
        <property type="entry name" value="Mannan endo-1,4-beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040722490" description="mannan endo-1,4-beta-mannosidase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="12">
        <location>
            <begin position="77"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5488753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="385" mass="42961" checksum="9A73666FFE08B79C" modified="2023-11-08" version="1">MRQTLLANFLLWTGLAAGYAVGLDQSPEQRSVEGVKLRLPAPSQDGLHFVIDGRPDYFAGSNSYWIPFLKSNADVDMVMKHLKQSGLKVLRVWGFNDVNEVPTDGRVWFHHIENGQSTINVGPDGLQRLDYVVRSAEAHGVKLIVNFVNNWSDYGGIAAYNTAFGGNATTWYTDKASQTSYRDYIKAVISRYRGSPTIFAWELANEPRCRGCDTSVIYNWAKSTSEFIKSLEPTRMVCIGDEGMGLNTQSDGSYPFTYYEGVDFEKNIQIPTIDFGTLHLYPSQWSEQDSWGNLWIEAHGAACVKAGKPCLLEEYGSLAHAPSEAPWQQTALKTKGIAGDTFWQYGDQLSTGPSPNDGYTIYRGTANYTILVTDHVKAIKHARRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDK2</accession>
    <name>A0A9W9XDK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_004146</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791289.1">
        <property type="nucleotide sequence ID" value="XM_056933748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDK2"/>
    <dbReference type="GeneID" id="81623997"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000326">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.150:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="355"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5489256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="475" mass="53017" checksum="136D52D28E88AF28" modified="2023-11-08" version="1">MSLDPPSYLGSLQNNIRARPIPWEGAVRAGNITEDHLKKIKAVDKVRKEQRIQTIKADLPGYTALLAGGSESKSVLESASRRTDIVQYILVLASDLIQDVSELADSLVSHPEPYKPFLPFLHSSNNAEDPIPLLTSTFLTALVSHSLVTSSKPAARDEEALPKLYLYLSTLTKNSDSGLQDIGVQGFSELLRKKHAREIFWKHRTETLDPLIETLRTAAGTKENGGSAGGIGTRSVEPGLAGGVGLQLLYRILLVVWQLTFESELVGEDLQENYEIIQLYTQLLRLSPKEKTTRLLLATLFNLCSSNRSTLLPVAVFVRLPALLSNLAGRHLMDPDLLEDLNGLSTMLDEYTKTQTTFDQYAAEVQSGHLRWSPPHKNPTFWKENARRILDEGNGALPKKLAEILSKDWEHDKQVLAIACNDVGHLVKELPERRAQLERAGLKTRVMELMADKDEAVRWESLRAVGEWLRYTFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDM9</accession>
    <name>A0A9W9XDM9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RIC1 C-terminal alpha solenoid region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_004254</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791397.1">
        <property type="nucleotide sequence ID" value="XM_056933856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDM9"/>
    <dbReference type="GeneID" id="81624105"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009771">
        <property type="entry name" value="RIC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25440">
        <property type="entry name" value="Beta-prop_RIC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07064">
        <property type="entry name" value="RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIC1 C-terminal alpha solenoid region" evidence="4">
        <location>
            <begin position="829"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1020"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1057"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1020"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1057"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5489364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1083" mass="119906" checksum="33331118CEE0FAC4" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDP2</accession>
    <name>A0A9W9XDP2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exosome complex subunit Csl4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_004013</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791156.1">
        <property type="nucleotide sequence ID" value="XM_056933615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDP2"/>
    <dbReference type="GeneID" id="81623864"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000164">
        <property type="entry name" value="Exosome complex component CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Exosome complex component CSL4 C-terminal" evidence="4">
        <location>
            <begin position="88"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5489123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="26483" checksum="B57FF59982C4F2ED" modified="2023-11-08" version="1">MTTSVPKLAIPGQRLGSISAYSAGPGTHVQQSNIYASIAGPVVVDPAISQTNKKSILRVSRIVAGIDPSKSNQASSAASKKKPRYNTLPAVDSIVLARVTRVQKRQVTVSILVVLDDTTPANPEANQAASDNDNIASILTTAANPENHSSTDELRFQALIRKEDVRAVEKDRVVMDEMFRVGDIIRGSVLSLGDQSFYYLTTARNDLGVVMARSEAGNMMFPVSWKEMRDPVTGAGEQRKVARPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEJ9</accession>
    <name>A0A9W9XEJ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7053 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791325.1">
        <property type="nucleotide sequence ID" value="XM_056933784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEJ9"/>
    <dbReference type="GeneID" id="81624033"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055481">
        <property type="entry name" value="DUF7053"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117:SF2">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23155">
        <property type="entry name" value="DUF7053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7053" evidence="2">
        <location>
            <begin position="3"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="309" mass="34574" checksum="831C4D2987C6A493" modified="2023-11-08" version="1">MLRKRESYTHFTPIPACVPRQLALDILHSHGEIITLNPLVLSYQPIAAPRDAAADEFYFSWYEIVERVQYLPGLGKIGSGKVNFHGCFHNTDWGLETHTFVPLGIEIKSRWRIAGNQVNEPRKFTEFRHDRAPENGLYLQEDIEINCNITLVSFVKGQLKAASKVLVDRLIKKAELLDAGVLQGYVEGGRLKTINPADRSSVARSDSLLSSSRRHSDMGSLRSYELPRSPTGSIREQSAYSPSRGSQRGSAKQGFVAELPADFHHRQPSQDSPNDRSRKYAAELPATMESPEGYVPSKHGIQELPPGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEY8</accession>
    <name>A0A9W9XEY8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792163.1">
        <property type="nucleotide sequence ID" value="XM_056932204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEY8"/>
    <dbReference type="GeneID" id="81622453"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF44">
        <property type="entry name" value="PHOSPHATASE C1620.13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5491034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33410" checksum="0654DC312A8D3ACC" modified="2023-11-08" version="1">MRIYLIRHGETVHNVAQVWAGSTDSALTNHGMLQIESLGRFFANRPIQFDHVYSSDLSRARITAEGICRMQPSMVNGAPLTPILSPDLRERDFGSLEGVRIQRATGTPVENFSQIVTDREKVPIGKEKESKESMRKRSLNFLQTHLLPLLLEEEEHYERRVAIVAHGLILRALWFCLTGFFDPSSISVMPGTAAWNGGPPALLSPVWSNTGVMEILISMRPICSSPAPQYPDMDHGPDEALYQAETAQPDSKVLPLLQGWSMKIVGADNTEHLAGLRRTRGGIGSASYDSRQKRIDSFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFC7</accession>
    <name>A0A9W9XFC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_002811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792373.1">
        <property type="nucleotide sequence ID" value="XM_056932414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFC7"/>
    <dbReference type="GeneID" id="81622663"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF0">
        <property type="entry name" value="METHYL-CPG-BINDING DOMAIN PROTEIN 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="3">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5491244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="207" mass="23724" checksum="1E1DBA9E8AE84B70" modified="2023-11-08" version="1">MPVLFGVFERYPTVEAMASADPTEFVSMIHCLGFQNQRARKCISIAQIWQRDPPVKNKRYRKLHYPKKYDGRDVALEQCLDDEDHRVAWEIAHLPGVGAYSLDSWRIFCRDELRGLAQDWKGTGATEPGFVPEWKSVLPQDKELRAYLTWMWLKEGWVWDCHTGDLSAAGDKTLRAAHREGVAHEDGGNWVLQTSPVKKSLNGLRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG14</accession>
    <name>A0A9W9XG14_9EURO</name>
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        <recommendedName>
            <fullName evidence="10">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_003126</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5491559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_056932729.1"/>
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    <dbReference type="GeneID" id="81622978"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:chromatin binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Bromodomain-like_sf"/>
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        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054551">
        <property type="entry name" value="RSC4_Ig-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF19">
        <property type="entry name" value="PROTEIN POLYBROMO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
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        <location>
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            <end position="174"/>
        </location>
    </feature>
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            <end position="73"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5491559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="491" mass="53683" checksum="2958125A0611900F" modified="2023-11-08" version="1">MSTKRRGAAAASPDMRLRGQKRRKVSEASPVSPEADQTPSPEASAEAVEQAEDEEGGSAAPAEDQEPEEDFEGDSIQTAQDKIMAELLRLKDDDGEDVAYPFIGKPDRNLYRDYYEVIHHPTSLRTIQKQVRGTDSRKNPSRTTAFPTWKLFEDEVAYIWRNAREYNEDGSDISNLAGILEFLGLTMKVTGQTSETPAKEEDTPTGAYVGDTSNKQRADTARTHSTSQETDAHRTSPRHRSLRRNVASPSKSNATITPSPADQPSETSAMPKAAFNRVNSEVAGQAPQPSETADAPHGGDNAPSETHESKTTSDDLEIFNLKSDYNLLTLITAPGPASAPPPAPFNALESIVRRPGEDARSALIRNVHVFTHESLNLNHSFNVHFPASNTLTQHSMTITLPATHNLVTIKPTVMQSSEQRHVKLVARVGMQRLHQSANDPTGMTFDLPLPPGLTTVHLEAIAGPERGVARIGPSGSDIDYERVTIFFQLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG36</accession>
    <name>A0A9W9XG36_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8004 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
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        </lineage>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792101.1">
        <property type="nucleotide sequence ID" value="XM_056932142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG36"/>
    <dbReference type="GeneID" id="81622391"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058317">
        <property type="entry name" value="DUF8004"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601:SF2">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8004" evidence="2">
        <location>
            <begin position="349"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
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        <location>
            <begin position="756"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5490972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="870" mass="96479" checksum="2C99965027FB45CF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG49</accession>
    <name>A0A9W9XG49_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SURF4 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002569</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792131.1">
        <property type="nucleotide sequence ID" value="XM_056932172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG49"/>
    <dbReference type="GeneID" id="81622421"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01339">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5491002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="323" mass="36296" checksum="2D7361F652310D4B" modified="2023-11-08" version="1">MAQIRGTAGYNLGHQNPFGGPSSADATSDPSPLDAIREQTSKIEDWLDTLADPVKPYLPAIGRFLIVVTFIEDSLRILTQWSDQLVYLRDFRKRIGVVLSSFQTRLTSPIYVLVPWGITHMFLITNVIAMSVCSFLVIARKRTEYAVAGLLAVVITQGLGYGLIFDLNFFLRNLSVVGGLLMVLSDSWVRKKFVPAGLPQLDEKDRKMYVQFAGRVLLIFLFIGFVFSGSWSFWRILVSLFGLVACVMVIVGFKAKWSAIILVVLLSVFNILVNNFWTLHPHHPHKDFAKYDFFQILSIVGGLLLLVNMGPGQLSMDEKKKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGJ7</accession>
    <name>A0A9W9XGJ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Probable aspartate--tRNA ligase, cytoplasmic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_001343</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792977.1">
        <property type="nucleotide sequence ID" value="XM_056930946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGJ7"/>
    <dbReference type="GeneID" id="81621195"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000038">
        <property type="entry name" value="Aspartate--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000132">
        <property type="entry name" value="Aspartyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="232"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5492597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="544" mass="60655" checksum="F5C89D106A3A1EFA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGQ5</accession>
    <name>A0A9W9XGQ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">Glutathione reductase</fullName>
            <ecNumber evidence="3 17">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">N7539_002854</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 17">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="14">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="3 17"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792416.1">
        <property type="nucleotide sequence ID" value="XM_056932457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGQ5"/>
    <dbReference type="GeneID" id="81622706"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000141">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF1">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 14 16" id="KW-0274">FAD</keyword>
    <keyword evidence="6 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0520">NAD</keyword>
    <keyword evidence="8 17" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11 16" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="19">
        <location>
            <begin position="89"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="18">
        <location>
            <begin position="437"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="264"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="15">
        <location>
            <begin position="127"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ5491287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="552" mass="60377" checksum="3F39E28BA72A125F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGT8</accession>
    <name>A0A9W9XGT8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Structure-specific endonuclease subunit SLX4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SLX4</name>
        <name evidence="11" type="ORF">N7539_001472</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a heterodimer with SLX1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">Phosphorylated in response to DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SLX4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGT8"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22999">
        <property type="entry name" value="SAP_SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03110">
        <property type="entry name" value="Endonuc_su_Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027784">
        <property type="entry name" value="Slx4_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018574">
        <property type="entry name" value="Structure-sp_endonuc_su_Slx4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09494">
        <property type="entry name" value="Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="36"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="255"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="634"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="711"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="711"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="723"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5492726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="856" mass="93092" checksum="F6ACF47AE88903D7" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGU9</accession>
    <name>A0A9W9XGU9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Alkaline phosphatase</fullName>
            <ecNumber evidence="3 15">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_001482</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="3 15"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793116.1">
        <property type="nucleotide sequence ID" value="XM_056931085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGU9"/>
    <dbReference type="GeneID" id="81621334"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.40:FF:000002">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000063">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 13 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="557"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="12">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5492736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="607" mass="65934" checksum="388865EF0E37C3EF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGZ0</accession>
    <name>A0A9W9XGZ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_001589</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793223.1">
        <property type="nucleotide sequence ID" value="XM_056931192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGZ0"/>
    <dbReference type="GeneID" id="81621441"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF94">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="633"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="130"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="354"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="416"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="636"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="638"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="649"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="654"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="660"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="663"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="678"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="681"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5492843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="699" mass="75934" checksum="497819638C6F1E8E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH72</accession>
    <name>A0A9W9XH72_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">homoisocitrate dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_001554</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R,3S)-homoisocitrate + NAD(+) = 2-oxoadipate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:11900"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.87" evidence="12"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793188.1">
        <property type="nucleotide sequence ID" value="XM_056931157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH72"/>
    <dbReference type="GeneID" id="81621406"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047046">
        <property type="term" value="F:homoisocitrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000012">
        <property type="entry name" value="Homoisocitrate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF48">
        <property type="entry name" value="HOMOISOCITRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="10"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5492808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="362" mass="38486" checksum="C60A0560AC63B915" modified="2023-11-08" version="1">MAAAAARTLRIGLIPGDGIGREVIPAGRRILEALPASLNLKFSFVDLDAGFETFQKTGSALPDKTVDTLKKECDGALFGAVSSPSTKVAGYSSPIVALRKKLDLYANVRPVKTTAGSSNGKPIDLVIVRENTEDLYVKEERTVEGPNGKVAEAIKRISERASHRISTIAGEIALRRQGIREAAPGTSSHSQPMVTITHKSNVLSQTDGLFRETARQALAAPRFSSVQVEEQIVDSMVYKLFRQPEYYDVIVAPNLYGDILSDGAAALVGSLGLVPSANVGDGFAIGEPCHGSAPDIEGQGIANPIATLRSVALMLEFLNEPDAAAKIYTAVDANLDEAKFLSPDMGGKATTQQVLDDVLKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH91</accession>
    <name>A0A9W9XH91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793326.1">
        <property type="nucleotide sequence ID" value="XM_056931295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH91"/>
    <dbReference type="GeneID" id="81621544"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="350" mass="36710" checksum="F3CD0CEDCC9392C7" modified="2023-11-08" version="1">MCPTIVSRLSDGPAILLSPSQDRVFGQLPSQSLLDVHTDFHTYSGTFNSTFGASKSTQPAVPVQPKVSRKRSRDESVVDELLLADGSSPQEASGEAQPSLNMAGSIPSGLQNGLGPSIANPAGAVESQQGAAAVLDSQGISRKAQRLDASTSGFGQTSATGSHESASGSIVADLHRTSPPSPPAEPLVDEATRLLGISWQRVDTDPDMAPAVRGWTKYIDNQYSAHLHDSQMLMKSRALSAYLVAATPNSSSCTSFYLFNEDLTQGQLVASSWEACLHNLRYTPPVFEGNAVIVAAGRPEPTSNPFTSTSESGVPLLQQALSSHTHVAPCGMTAGMGLNQGVDMGMEIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHA4</accession>
    <name>A0A9W9XHA4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminodeoxychorismate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_001724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793358.1">
        <property type="nucleotide sequence ID" value="XM_056931327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHA4"/>
    <dbReference type="GeneID" id="81621576"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5492978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30205" checksum="F22AC8A91BFB55AE" modified="2023-11-08" version="1">MTSHDCGTPTPSFQIISSLRYDPELPRVTGSLPTDEYFPVPRHSPYYLLSYHRDRLINAAKHFQWDEALESLQKDLSVFEDFLNSAIENKVKSWRLRILVDRHGKGLVEVNPVGAMDCWNLLVPPLHKSVPDVIWNVYVDSQATIPSGFTTHKTTARDDYSAARARAGITSPADTSEVLLVNPDGQIMEGSITTPYFRRRVLPESHDTSQPTWVTPPLKCGGNAGTSRRYALEQSFCVEQLIMSAELVDGEDCWLSNGVRGFVKGVVILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHB6</accession>
    <name>A0A9W9XHB6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">ABC transporter G family member</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_001291</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792925.1">
        <property type="nucleotide sequence ID" value="XM_056930894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHB6"/>
    <dbReference type="GeneID" id="81621143"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000702">
        <property type="entry name" value="ABC transporter (Adp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF2">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040969625" evidence="15">
        <location>
            <begin position="24"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="835"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="868"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="911"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="948"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="978"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1064"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="81"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="370"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="634"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="737"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="634"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="657"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="691"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5492545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1090" mass="120679" checksum="1442DBF30AB3495E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHC9</accession>
    <name>A0A9W9XHC9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_001772</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793406.1">
        <property type="nucleotide sequence ID" value="XM_056931375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHC9"/>
    <dbReference type="GeneID" id="81621624"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF28">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="11">
        <location>
            <begin position="18"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5493026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="470" mass="51826" checksum="569AF0A6C86A0E80" modified="2023-11-08" version="1">MSSYALPESHKDQMHNSLKESDPEVAEIMAKEIQRQRESVVLIASENFTSRAVFDALGSPMCNKYSEGYPGARYYGGNQHIDAIETTCQQRALKAFNLDSSKWGVNVQCLSGSPANLQVYQALMRPHDRLMGLDLPHGGHLSHGYQTPARKISAVSTYFETFPYRVNLETGIIDYDQLETNAEMYRPKILVAGTSAYCRLIDYKRMRQIADKVGAYLVVDMAHISGLIAAGVIPSPFEYADVVTTTTHKSLRGPRGAMIFFRKGVRSTDKSGKEIMYDLEGPINFSVFPGHQGGPHNHTITALAVALKQAATPEFKQYQELVIKNAKALENEFKALGHKLVSDGTDSHMVLVDLRPKSLDGARVEAVLEQINIACNKNSIPGDKSALTPCGIRIGAPAMTSRGMGEDDFKRIAGYIDQAINLCTKIQSELPKEANKLKDFKAKVASESVPEILELRKEIAGWASTYPLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHF7</accession>
    <name>A0A9W9XHF7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ribonuclease T2-like</fullName>
            <ecNumber evidence="4">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">N7539_001838</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the RNase T2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793472.1">
        <property type="nucleotide sequence ID" value="XM_056931441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHF7"/>
    <dbReference type="GeneID" id="81621690"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.730.10:FF:000004">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057328">
        <property type="entry name" value="RNaseT2L_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25488">
        <property type="entry name" value="RNaseT2L_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="RNase T2-like C-terminal" evidence="19">
        <location>
            <begin position="295"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="251"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF25488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ5493092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="417" mass="46542" checksum="CF30E0F064A07EDE" modified="2023-11-08" version="1">MGYLQPQTGGNLGPQKILKALSTWWLSSTADDKQSTAPGVSRSCSSGEISCQIQYHGQDTCCFNYPGGQMLQTQFWDADPAVGPDDSWTIHGLWPDHCNGGFDQFCDPKRRYSNISLILVDAGRADLLQYMTEFWKDYKGDDSHLWQHEWEKHGTCVSTLETRCYEDYQPQQDVVDYFDKSVEIFKQVPSYEFLAANGILPSHTQRYALTDIESALESGHGAPVTVHCRQGALSEIWYHFNIAGSLQTGRFVPAPPDGQKSNCPKSGIRYPPKRSTPEPTKTTSRGSEPTHTGHPKTQRGNLMVSSLGHRRGCIISYGTWFTSGTCATFRTQKVTDNTFTLKSSKGFCAFEDDALRCHSHVNKPSEFTITEGKVSYAGNTTFYADKAPKGHVQSIIYASQAEHLLELELEWSPKGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHP6</accession>
    <name>A0A9W9XHP6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792939.1">
        <property type="nucleotide sequence ID" value="XM_056930908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHP6"/>
    <dbReference type="GeneID" id="81621157"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076:SF1">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076">
        <property type="entry name" value="CYANOVIRIN-N HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanovirin-N" evidence="1">
        <location>
            <begin position="3"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="383" mass="43046" checksum="7BFDF9D749B84DE4" modified="2023-11-08" version="1">MPSFSTLSRCICLSENAMLQASCQNDHGLWEQQSFNLNDILGNEEGYFKLGSQAFSRSARRICLLSSSPPILKAELRTSNGTWREDSVNLDHFIAVHHGRLAFKNARSAPNFLLELGKQRGTFLDNVRAKIESYVEETGVDCLAVIEKKPESVDETHEPGDLEFAPAFFFFLIERRYRGHECESALIQPIIDIISNSFSELMSANSEKLQLYLGEQVIQSFANFSRSEIRKGCIKNTTDLVNKVIMKTMLLKAKFSVLKPLVKTQLQGGLKSLISKTIIKSLLKAAGIGKLSLLKGAFTTLFAGYIIYKITKFPRDLGKSLSAGLNAMLEDNLEAMTQSLFKTVQSEVVDMCKGKVTEHFGEALKEEFKEEFKEAIKERWKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHS7</accession>
    <name>A0A9W9XHS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylglutaconyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_001885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793519.1">
        <property type="nucleotide sequence ID" value="XM_056931488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHS7"/>
    <dbReference type="GeneID" id="81621737"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000058">
        <property type="entry name" value="Enoyl-CoA hydratase/isomerase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5493139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="312" mass="33468" checksum="5F5C7BE372A4E161" modified="2023-11-08" version="1">MATATLSPRLIRLTGLGHLSRPTVLSSRAFAARYSTSSEDEIIKTQQIPAPGSGHVRVLLLNRPKARNAISRQLLETLAKQVDSIAAENGNGPTRALVVASNVDASFCAGADLKERAKMTPAEIEQFLEKLRATFKGLANLQIPTISAISSMALGGGLELALCTHLRVFGSSCTVGLPETRLAIIPGAGGTYRLPALIGPTRARDLILTGRRVSGPESYFIGLCDRLVEVTPEEGQQEGVAREKVLRESIKLALDICEGGPIALKQALLAVQGSTLGEVSENRAYEGVIETEDRYEALRAFAEKRKPVFRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI39</accession>
    <name>A0A9W9XI39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793791.1">
        <property type="nucleotide sequence ID" value="XM_056931760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XI39"/>
    <dbReference type="GeneID" id="81622009"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="174" mass="20345" checksum="BCF197F93790FBFF" modified="2023-11-08" version="1">MVIVWTAEWDTKLLVAIWETCGSKFDWESAAEILGKACTPEAIMQHLRNLTKKASDQRREQREVLLKSHAARDASVAKGKARRRWGYSRINYARRRPSRKVVTQDQSPADEQPSKAAPIPRKRRFQDDLPLFKPIEEEIERRPPQINRTRKRHFREAPESPDEDHNSSQRTSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI55</accession>
    <name>A0A9W9XI55_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_002187</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793821.1">
        <property type="nucleotide sequence ID" value="XM_056931790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XI55"/>
    <dbReference type="GeneID" id="81622039"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002054">
        <property type="entry name" value="DNA mismatch repair protein MSH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="7">
        <location>
            <begin position="214"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="8">
        <location>
            <begin position="556"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="813"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="849"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5493441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="878" mass="97200" checksum="36A9DD0DA220834D" modified="2023-11-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XL82</accession>
    <name>A0A9W9XL82_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_000193</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794090.1">
        <property type="nucleotide sequence ID" value="XM_056929797.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81620046"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="5"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5495077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="229" mass="25313" checksum="00B8ED15A06C0FBB" modified="2023-11-08" version="1">MTDLLSLPNEVLLLIAGHLAWQRDIHRLAQTNSRLYNLLDRHLYRYNAERDHSSALLWGAERGREATVRKALSEGANVQARSEGNRTPLSWAANNGHTEIVQLLLRSEGVNPDHPTYGGETPLVLAAWNGHEEVVRLLLATPGVDPNFQTARGETPLSLAAYRGHTGIVKRLLDTGCVDPYAQNFRGETPLTLATGTGRHEVMKMLLNLQSHGFSSKVSDPGRWKIVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLA9</accession>
    <name>A0A9W9XLA9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_000238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056929842.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81620091"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5495122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="275" mass="30425" checksum="2CD332E3C7D0ACDA" modified="2023-11-08" version="1">MSDTWVIVGASRGIGLEFVRQLLHNGFHVIAGVRNLSKAEKLDEVKSQQAGPERCIIEQCDITDEQSIQGFADKVKEATRVNGLKVTNIVLNAGILHYPNRATEISFADFALHLHTNTIGPIICAQKLLDLNPDSPPSKVVFISSDSGSTTIFRDDEDGFGAYGASKAALNQMLRHMAAELTRKGGQWTRTRILAMHPGEVETDMANIDLGWEVHGSISAEESVRCMLKVISEKDETGSFWCWDGRVPGQMPSIEKSHESMTSKLIGRWKSREFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLF2</accession>
    <name>A0A9W9XLF2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_000298</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794195.1">
        <property type="nucleotide sequence ID" value="XM_056929902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLF2"/>
    <dbReference type="GeneID" id="81620151"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11398">
        <property type="entry name" value="bHLHzip_scCBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047206">
        <property type="entry name" value="bHLHzip_scCBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787:SF1">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="185"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5495182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="306" mass="33621" checksum="733FB9C7946981C8" modified="2023-11-08" version="1">MTDMPAASQDSFFETMSDPTMASPDGAGGKRKREGSEDLGHDAQRLNRSSHGSNGSMPDNQHAFSHSMGYDHGLGNAGSELNIDQQILQHVGPQNGLSDDNALTANAKAALAAHAPQHKYPPPPDAAAFDANNLTQGLNFGDDMGQGPMPGPHNHNSTAAAVYAAREAQSMNQKPTVGSPEWHQIRKNNHKEVERRRREAINEGINQIARLVPNCDKNKGAILQRAIEYICQLQDDKKNMDERFEQHSLTANHAINEISASNQKLKQEVSRRNAIAAKWLQRCRDAGLEFDDYEEAKELETLDGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM47</accession>
    <name>A0A9W9XM47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794505.1">
        <property type="nucleotide sequence ID" value="XM_056930212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XM47"/>
    <dbReference type="GeneID" id="81620461"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="86" mass="9929" checksum="29EA5E3707FF13F9" modified="2023-11-08" version="1">MQSSMESQSMPDRTRENPSASAPFAHQEALHRPPPTADSVSQQSWKPKYDRRQSWNHEDQKHALQERLLNLEPARETGFSETGREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMG3</accession>
    <name>A0A9W9XMG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_000386</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794283.1">
        <property type="nucleotide sequence ID" value="XM_056929990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMG3"/>
    <dbReference type="GeneID" id="81620239"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000138">
        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5495270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="485" mass="54215" checksum="D1CC91F3BACE7B6D" modified="2023-11-08" version="1">MTLAHPIRRVAIIGAGPSGLAALKFLLAEDCFECIDLFEQRSSVGGAWVYTGGPAKAGMSTTVPHLNPHEPVQRPIWDKREDGSSQAIFVSPLYERLETNIPKDLMRFSDLAFPSDAQLFPKHQTVQEYLDAYAAPVKGYIKFETQVVSLRLKNPSLSTWELTTTNLFDGLNTTQIYDAVVVASGHFNVPHLPDITGIKEWDRVYPGAISHSKYYDRPEQFAGKKVVVVGSSASGLDIGGQISEMSAGPVIVSQRSESYFAAASGTAINKVFRPEIVEFLPPAKYDRGVRFADGHIEENINAVVFCTGYFYSYPFLSSLKPPVITDGWRTRHVYQQLFYTEHPTLVFPVLPQRVIPFPLAENQAAVFSRVWSQRLQLPPKSEMEAWEAAQVDQKGDGKTFHLLPFPLDADYLEFLYTWAASAAPRPALSNGGHGRLGTCWTERERQIRKIFTEIRQSFVNKGIERSSVRTLEELGYTFDAPMVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMT2</accession>
    <name>A0A9W9XMT2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794836.1">
        <property type="nucleotide sequence ID" value="XM_056930543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMT2"/>
    <dbReference type="GeneID" id="81620792"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004354">
        <property type="entry name" value="Meiotic_Rec114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03525">
        <property type="entry name" value="Meiotic_rec114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="500" mass="55142" checksum="C178BD48CDAA8C5A" modified="2023-11-08" version="1">MARTLAPLASRLPLSKFSFTTTTINSHSRMIWTHINGDGTLFCETESRTRSSTHAQSFHLKVVQNNSVLEEIDLTAHLENLRNEPSSSQTSSRQKPSFVVVVKLPCLAIKFPLDDTHIRRFQIKFSQDHDYYTMLSMLSGMNCPLTEGTWPAAGRHPSSTSAGTAQTTLNLRQDMGNAITPESIRAGSCGGMTNAQCRHDIGVSLDGSASDKGCSYLSPVPRAPSLPSAQVPSAICRGVISLTEPHDIPANEEGMADSKPQLPRAQEALNHSPEPSSQPTSGPVSRHEDINQMLPPKRALPFPRNRSKVSRADTASLKSSQQIVPESSYPDQSTNRRHESLASDLQSQLIQPHKSPQPDVTDQYDAFRSNSQSQLFQTQALPDTLEPSRQSTQLPPTLPLPRLDRQVQAEIFTPFVQQSQVDTPMPPEANAPQIQGRPAAVRLVHTPVEGQLAEYAKASTTERTAFLENWMCELIEDDNFVTLCEDVENTWRRFAFGAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ57</accession>
    <name>A0A9X0BJ57_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_009463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785780.1">
        <property type="nucleotide sequence ID" value="XM_056939058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJ57"/>
    <dbReference type="GeneID" id="81629308"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5466734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="325" mass="36650" checksum="A85952CC98419C08" modified="2023-11-08" version="1">MLLLATETRLSKIDNGSSLLDRLDHPGFLEDALYAERWDVLRETFKFYRAHKVPEAVLAHFLRDLMAYAVDRLRYLGMNHDCLEVMLELGLDKHMDRPPRYGGGTLLHFALGSEWIRILMDGGFNLVNYRNELGKTAFHQFLLQWKYEQARTIMSYGCDLTWQDVRRQTPLHSSIRAIIEASGYFLDISSSPYGTVSKCLSLVATLLRQGADASTRDNCYCPCSPGGCSPLLQLLRASAAWSPEERFVQPIWALEILIMIDELQSSLITQQAVDDMLRVKEFQSLEMTHVCCCGSSPIGRTGTTIAADEIDEIIDEEKVLGGSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJE2</accession>
    <name>A0A9X0BJE2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_009420</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785737.1">
        <property type="nucleotide sequence ID" value="XM_056939015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJE2"/>
    <dbReference type="GeneID" id="81629265"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040756051" description="CFEM domain-containing protein" evidence="10">
        <location>
            <begin position="17"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="11">
        <location>
            <begin position="489"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="179"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="299"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="574"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="696"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="193"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="587"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="712"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5466691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="770" mass="82243" checksum="685425FA0358AD49" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJI9</accession>
    <name>A0A9X0BJI9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786246.1">
        <property type="nucleotide sequence ID" value="XM_056938869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJI9"/>
    <dbReference type="GeneID" id="81629119"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776:SF1">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5469656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="51108" checksum="FAC8C497EE82676A" modified="2023-11-08" version="1">MARTSSRQAAQKANEALSTRKASAKPPAGRKRKASQKDAPEAKKEKVEEQQPDKPVESEQKADAEHHQHGDAPETKKVAETSQPENQKALDVKVESQQLQEKSEQDKQVGNGPEEEESTRDTTQKASSTHHDAAGSSSKSELGVRTSEEREEKVSSNILEKGIIYFFYRSRVNVDDPHGMKDIARTFFVLRPTPIGAELDSNQGPVDKNARCRLLVLPKKKLPTSGKERDMAFVEKVNQSVKDLQEHFIAGSTYQTATRGERHVEEAQPFAEGVYAITSAPRASHLAYILTIPSEPGDLQDNFGIHQRGSFIVQSKNPKYPGPASAQLPEQPKYPESIMEQFRDLRWVPLRPEFIDYPNAQLLMIGEAHDSLGKAATAEVEKKPQESEPGDELEEMEHENEERVHALGGERSRSTEMVLSQTNRDFTSGDGAIFQDLGLDAKKHAGVPTTWDATVKDEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJR3</accession>
    <name>A0A9X0BJR3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Interferon-related developmental regulator N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_009110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFRD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786082.1">
        <property type="nucleotide sequence ID" value="XM_056938705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJR3"/>
    <dbReference type="GeneID" id="81628955"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039777">
        <property type="entry name" value="IFRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007701">
        <property type="entry name" value="Interferon-rel_develop_reg_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354:SF1">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05004">
        <property type="entry name" value="IFRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon-related developmental regulator N-terminal" evidence="3">
        <location>
            <begin position="58"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5469492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="465" mass="51647" checksum="3A49E77483D46196" modified="2023-11-08" version="1">MPDLRRQVLESGKTVSRKAASREASRTNSRSSSKQTSLQSSRAASRQASDDEESGFLSDDTALSIGSLDDENPETENVDWPQELSDRVAEILDRKRSSVQGREEALAAFCRLTKYHYAEEEIRPFVSDLLAAFAKSIRSESSVREATLALRAIELLVITSCDDKIYDNAEPLLTRCIRDSTSTAIKAAAIYCLGACSNFGGAGEEGILEQMTFLLDIIASDGQSIDAADDAVSVTAALHVWGFLLSEVDDFEEESEEAVQIFMDQLDSGDSGVQIAADDDDEDSEEEEGGSDEQESKDLTSGPKLIKRYNAYHNTAELERQLANLATIHSKRISKRDKKSLHSNFTSILTTVENPRRGPRYNMAIDQATNKHYGSTLTVKIGRHGVMRIDRWWKWVRLTSLRRILQGGFAEHYFQGNRAVLDNLPVMMRMPNASGSGDRPAAKKAARMRNAKRWTGPSDDDEEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BLP3</accession>
    <name>A0A9X0BLP3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786466.1">
        <property type="nucleotide sequence ID" value="XM_056938084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BLP3"/>
    <dbReference type="GeneID" id="81628334"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040:SF1">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5471920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="126" mass="14619" checksum="3C462E13D473A45E" modified="2023-11-08" version="1">MELPPRRFSKGLINGLGKCIEHDTLMTISERAKRKACKDGGRKLFAPEYGGSYEVFITRPLSAEIMQYCAQDVQLLPGLWHEYYQRMTPRWERKVEEEMENRIELSHSETFNGKGKHMALAPKGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BP00</accession>
    <name>A0A9X0BP00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_007422</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787822.1">
        <property type="nucleotide sequence ID" value="XM_056937023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BP00"/>
    <dbReference type="GeneID" id="81627272"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5477278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="240" mass="26076" checksum="65FAD24FA26DB22B" modified="2023-11-08" version="1">MADRFPSLEDFSEGQTEVIKSNGGTEDDFLARERAALGEDADQFATPQDHVATTNAGDDDLLGGGDDTPAEEIGQFESAFPSVDTQTQNERVAPGGTITGSGSPFPRTGYGSMETEEEEPEPIRQWREKRDAELARRAQISEEKKEATMKKAQQDIDDFYVAYNNKIDKLKGQTRTEAEEFLASREDTSAGGTSWERIAKLVDVSGKGTTGGASGSGKERFRELLVDLRKDQEAPGASGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSC6</accession>
    <name>A0A9X0BSC6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_006858</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788394.1">
        <property type="nucleotide sequence ID" value="XM_056936459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSC6"/>
    <dbReference type="GeneID" id="81626708"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000058">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="5"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5480964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="276" mass="30436" checksum="F4B3B8CDD29ED13C" modified="2023-11-08" version="1">MATKAAYKRLTREYQNIQKNPPPFIIAHPSESNILEWHYILTGPPGTPYENGQYWGTLIFPPEYPFAPPAIRMHTPSGRFQPSTRLCLSISDFHPKSFNPAWEVSTILIGLLSFMTSEEMTTGSVSASEGERRVLAARSRWWNSTGGGSHINATPGVARTTKGINNVKAGDGGLKFRTEWPELDQENWTWMKEHRIDTATGQILPDPDAAAKCSPETSALRRRPTGSAAGLGAVMEGGQVAREAGQGWARRNRFWIGVAVLLGYALVSRMVNDVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSP6</accession>
    <name>A0A9X0BSP6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Terrelysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aegerolysin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788276.1">
        <property type="nucleotide sequence ID" value="XM_056936341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSP6"/>
    <dbReference type="GeneID" id="81626590"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019836">
        <property type="term" value="P:symbiont-mediated hemolysis of host erythrocyte"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009413">
        <property type="entry name" value="Aegerolysin-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06355">
        <property type="entry name" value="Aegerolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5480846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="140" mass="16123" checksum="93B2237F23604287" modified="2023-11-08" version="1">MEEELNNYNSQWVAFHIRDHLKDGEITVQNTVIEGGEFQDPNNRRKSLTEDEIDYMTIESEGVGEICARGRRGSEGRLDLFHGNTKICELHWENRGGEYHNLVEVLDDNSKYRIEHGGWSPQAGPLGHVFVDIREKNAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BT53</accession>
    <name>A0A9X0BT53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789073.1">
        <property type="nucleotide sequence ID" value="XM_056936149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BT53"/>
    <dbReference type="GeneID" id="81626398"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5483101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="65" mass="7007" checksum="8098AE308AF9E279" modified="2023-11-08" version="1">MQSVEPDYFTCTLGEAVRGRGRPSSATTSFASIIDVIDQQAERYPDLPAIGFAQPREGQQNGSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BU21</accession>
    <name>A0A9X0BU21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase NADP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_005857</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789331.1">
        <property type="nucleotide sequence ID" value="XM_056935459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BU21"/>
    <dbReference type="GeneID" id="81625708"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF3">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G11600)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="4">
        <location>
            <begin position="6"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5484061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="314" mass="32890" checksum="C788D910ED57C624" modified="2023-11-08" version="1">MSGTCVTWIGLGNIGRGMSSNIAKKGPQTQLILYNRTSSRAVTHAENIGSNNVTVAQSLSEAVAASDLIFACVGDDAAIEAIAEEILSDKNADLSGKTFVDCSTVHPDTSRRLEASFTARGAGFVACPVFGAPIMADAGQMIVVPAGKQASIAKATPFFEGVTAKATIDLSDGSGTDVDVSRASTFKVLGNSFILNTVGVLAESLTAADATGLGTGPFRQWLELFNPGPFVKYADRMISGDYYQREEPLFAVDLARKDLRHAASLAKEGGQRMRNGEVMDGLLQGVKAEKGEKGDIAAVYGAARKAAGLKFENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUT4</accession>
    <name>A0A9X0BUT4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790036.1">
        <property type="nucleotide sequence ID" value="XM_056934842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUT4"/>
    <dbReference type="GeneID" id="81625091"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="24"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="265" mass="29723" checksum="1098C784890CCBE3" modified="2023-11-08" version="1">MRKTSVSEDPNLAENLDAFLTSCHDQVVTIRVKSTEGRAFRVSKKLLTEKAPYFAKMFSGGFLESEKDEVLLEEIDGVVSEASVATLIFWFYKDEIKLTLGTCESERTSRTTLYISAAIEVARLADMYGVTGFEEPLAESIRQSLCSSFEWGDTGLENIYDQDLASSENLPAGHPVRRALAKTFVASLMRSCDYRNFASDQLTAYPNLAVEIIRETIKALDTLETPKRGFTRFTITDPINLKDCGLKLPGLIRNPSDRNLQHVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BV17</accession>
    <name>A0A9X0BV17_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <ecNumber evidence="5">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_005510</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HMBS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790306.1">
        <property type="nucleotide sequence ID" value="XM_056935112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BV17"/>
    <dbReference type="GeneID" id="81625361"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13645">
        <property type="entry name" value="PBP2_HuPBGD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.40:FF:000002">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000086">
        <property type="entry name" value="Probable porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="13">
        <location>
            <begin position="12"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="14">
        <location>
            <begin position="239"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5485522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="331" mass="36072" checksum="9C382E5FD2B4C522" modified="2023-11-08" version="1">MAAVPTPPETPIRIGTRRSNLAVVQAEGIRDSLQKIEPHRFFEIVTLRPLGDRDKTTALYEMGVKNLWTCELEEKLVSGELDLVVHCLKDMPTALPETCELASIPPRDDPRDALIVKAGLPYTSLSTLPDGAVIGTSSVRRSAQLRRLYPRLNFANLRGNVETRLAKVDDPNSEYTCMIMSTAGLERVGLRHRINQCLQSSNGGMYHAVGQGALGLEIRKGDAQMHALLNQLADRRSTLACLAERSLLRTLEGGCSVPIGVETEWVETDTLHMRSIVVSLDGAQSAGAQVEARLENPEEAVVLGQELAAKLVEAGAQTILDAIIVNRPAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXT1</accession>
    <name>A0A9X0BXT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="20">CPR</shortName>
            <shortName evidence="20">P450R</shortName>
            <ecNumber evidence="20 21">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">cprA</name>
        <name evidence="24" type="ORF">N7539_003377</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20 21">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="20">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion outer membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20 21">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20 21"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXT1"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000009">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000100">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000111">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000024">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000001">
        <property type="entry name" value="NADPH--cytochrome P450 reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 20" id="KW-1003">Cell membrane</keyword>
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            <end position="538"/>
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    <sequence length="695" mass="76639" checksum="9FEF818498F1965C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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                <person name="Frisvad J.C."/>
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            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAPWDQ010000004">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056933460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BY34"/>
    <dbReference type="GeneID" id="81623709"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5488968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="714" mass="79103" checksum="84939396D0022832" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYK6</accession>
    <name>A0A9X0BYK6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_002363</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791925.1">
        <property type="nucleotide sequence ID" value="XM_056931966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYK6"/>
    <dbReference type="GeneID" id="81622215"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="12">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="870"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1020"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1048"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5490796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1060" mass="116344" checksum="E45F2FA13E6B762B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYR6</accession>
    <name>A0A9X0BYR6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002528</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792090.1">
        <property type="nucleotide sequence ID" value="XM_056932131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYR6"/>
    <dbReference type="GeneID" id="81622380"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5490961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="735" mass="81761" checksum="D8B78453702AE1E8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ31</accession>
    <name>A0A9X0BZ31_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="5">1.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">N7539_002843</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="25">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="23">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="24">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Dus family. Dus3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792405.1">
        <property type="nucleotide sequence ID" value="XM_056932446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ31"/>
    <dbReference type="GeneID" id="81622695"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000145">
        <property type="entry name" value="tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25585">
        <property type="entry name" value="zf-CCCH_DUS3L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="18" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="27">
        <location>
            <begin position="333"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="DUS-like FMN-binding" evidence="27">
        <location>
            <begin position="578"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00031322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KAJ5491276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="738" mass="82588" checksum="69DA7D129015245F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZN0</accession>
    <name>A0A9X0BZN0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002919</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792481.1">
        <property type="nucleotide sequence ID" value="XM_056932522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZN0"/>
    <dbReference type="GeneID" id="81622771"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="6">
        <location>
            <begin position="25"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 long" evidence="7">
        <location>
            <begin position="292"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5491352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="815" mass="89939" checksum="DD12C98FDA80AD4B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZU4</accession>
    <name>A0A9X0BZU4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S11-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_001534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793168.1">
        <property type="nucleotide sequence ID" value="XM_056931137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZU4"/>
    <dbReference type="GeneID" id="81621386"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000001">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="5">
        <location>
            <begin position="40"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5492788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="192" mass="22166" checksum="16F9DC48A218D47A" modified="2023-11-08" version="1" fragment="single">RIFLILEVLSRYPSRQPSIQIDNASSSTHTATMATELTVQSERAYQKQPHIFQNSKTQAKSKKAGQTRRWYKEVGLGFRTPKTAIEGTYIDKKCPFTGLVSIRGRILTGRVVSTKMHRTIVIRREYLHYVPKYNRYEKRHKNLAAHVSPAFRVEEGDWVTVGQCRPLSKTVRFNVLRVLPRTGKAVKSFNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZY2</accession>
    <name>A0A9X0BZY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">U3 small nucleolar RNA-associated protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_001743</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793377.1">
        <property type="nucleotide sequence ID" value="XM_056931346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZY2"/>
    <dbReference type="GeneID" id="81621595"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5492997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="391" mass="44891" checksum="7C166D9B942E0E2D" modified="2023-11-08" version="1">MSAATDKARFFLEQSVPELREYERKKIFTKEEITSIIKKRSDFEHKLNARGAAPIDFVRYFEYELNLDTLRKKRVKRLGIRAVGHSGQRRIYFILERATRKFHGDLNLWIQYIEFARKQKANKKLSIIFTDALRFHPTSAELWVYAAKYALDDHADMSQARSYMQRGLRFCKNSRKLWIQYAKLELIYIAKLVARQRILGLDEERPVPIEAANNDMGGDMVALPAITDEDVNPTRNDEEVDQQALSNLNSTPALTGAIPLAIFDAAMKHFHHDDRFGAEFFDMVLEFNETPCFHKIEEHVVDTLKTHQPTSPRAQVCYIKLPTAGVDVTSAAFPRAFGTSLARLKETAMTQDLAREVVAWLQPLVTVDNLDPALKKVFEATIRSAERSLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C001</accession>
    <name>A0A9X0C001_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793186.1">
        <property type="nucleotide sequence ID" value="XM_056931155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C001"/>
    <dbReference type="GeneID" id="81621404"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="501"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="625"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5492806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="759" mass="85546" checksum="352B0915CEA50385" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0E9</accession>
    <name>A0A9X0C0E9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">vesicle-fusing ATPase</fullName>
            <ecNumber evidence="4">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_001776</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793410.1">
        <property type="nucleotide sequence ID" value="XM_056931379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0E9"/>
    <dbReference type="GeneID" id="81621628"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02678">
        <property type="entry name" value="MIT_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002287">
        <property type="entry name" value="MIT domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045253">
        <property type="entry name" value="VPS4_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIT" evidence="15">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="75"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5493030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="418" mass="46143" checksum="867FC00E664A7513" modified="2023-11-08" version="1">MSNTDFLGRAIDTVKKAIENDNEGEYEKAYQLYYSALELFMLALKWEKNPKSKEMIRAKTGEYMDRAEKLKNHLASADKKKPSAVGANGKVAPGSGKGGGQEDDNGEDAEAKKLRSALQGAILSDKPNVKWEDVAGLESAKEALKEAVILPIKFPHLFTGKRQPWKGILLYGPPVQESLTSQKPLQPRQTAHSSALVKQLFNMARENKPAIIFIDEVDALCGPRGEGESEASRRIKTELLVQMDGVGNDSRGVLILGATNIPWQLDAAIRRRFQRRVHISLPDFNARTKMFMLAVGSTPCHMTPADYKMLAEMSEGYSGSDISIAVQDALMQPIRKIQTATHYKKVTVDGVEKLTPCSPGDAGAMEMTWLSVEAEQLLEPPLVVKDFIKAIKNSRPTVSHEDLTRNSEWTEEFGSEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0K8</accession>
    <name>A0A9X0C0K8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras-related protein Rab-11B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_002167</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793801.1">
        <property type="nucleotide sequence ID" value="XM_056931770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0K8"/>
    <dbReference type="GeneID" id="81622019"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000085">
        <property type="entry name" value="Putative ras-related protein rab-11a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5493421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="236" mass="26179" checksum="A66031C9978B83BA" modified="2023-11-08" version="1">MANDEYDFLFKGNVALLGNLLASSLLSRFLTHACVDNLELVLIGDSGVGKSNLLSRFTRNEFNLDSKSTIGVEFATRSIQVDSKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDISKHQTYDNVNRWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTEEAKQFASENNLSFIETSALDASNVELAFQNILTEIYRIVSSKALEPGEASANPPVGRTIDFTPQPNEQKQGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0L3</accession>
    <name>A0A9X0C0L3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sialidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793620.1">
        <property type="nucleotide sequence ID" value="XM_056931589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0L3"/>
    <dbReference type="GeneID" id="81621838"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="66486" checksum="AEB79377CA90F099" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0T0</accession>
    <name>A0A9X0C0T0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793679.1">
        <property type="nucleotide sequence ID" value="XM_056931648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0T0"/>
    <dbReference type="GeneID" id="81621897"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="262" mass="28098" checksum="814EC29F258E5BEB" modified="2023-11-08" version="1">MTTVLVVPGAWLTKAFYEPFLQALTEAGYDAQFAEYPSLDPEDPTAFDCHADSKAIAAVLRPLVEEEGKDVLVLMHSYAGMPGAAAATGLAKTQRVQQGKRGGVVGLLFVGAFVVPEGLSCAGLQGGNLPPWILLDQDQSVLTRDKPSANLNLADDPINNFAADVEGTLAQSLTAHSKPHATLSFTSPQPHPAWMDDEFKGRLASVVLTEDRAVPKEAQLGMIAATQQPWIVKELPASHCAPFLNRIDDTVALTREILDKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C228</accession>
    <name>A0A9X0C228_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Vacuolar protein sorting-associated protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_000172</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the retromer complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the VPS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794069.1">
        <property type="nucleotide sequence ID" value="XM_056929776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C228"/>
    <dbReference type="GeneID" id="81620025"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07625">
        <property type="entry name" value="BAR_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000046">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000034">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014461">
        <property type="entry name" value="Retromer_complex_Vps17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011791">
        <property type="entry name" value="Vps17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="111"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="472"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR011791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5495056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="573" mass="63189" checksum="D9E483137F209F50" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2J5</accession>
    <name>A0A9X0C2J5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S.t1.c1 complex component sdc1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_000652</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794549.1">
        <property type="nucleotide sequence ID" value="XM_056930256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2J5"/>
    <dbReference type="GeneID" id="81620505"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22965">
        <property type="entry name" value="DD_DPY30_SDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049629">
        <property type="entry name" value="DPY30_SDC1_DD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5495536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="82" mass="8861" checksum="2BDCF41169B3F4C4" modified="2023-11-08" version="1">MAETNGGTGLQPLDLASGITPQIRPGGAPARVYLNEKIVPHLLEGMKAITRDQPPNPLQVLGEFLIQKSKELEEAEAKKESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2Y9</accession>
    <name>A0A9X0C2Y9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_000771</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794668.1">
        <property type="nucleotide sequence ID" value="XM_056930375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2Y9"/>
    <dbReference type="GeneID" id="81620624"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="5">
        <location>
            <begin position="63"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5495655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="387" mass="42404" checksum="63BB3095E1282E41" modified="2023-11-08" version="1">MSLPRSTRRLVPRVTNRCYSSAPSPRAKLNLPIDYKSTPILHHTPSSLSNVSEFPAGATSKKLNYFQAINSALRTALTKSDKVMLFGEDVAFGGVFRCSMDLQTEFGSERVFNTPLTEQGIAGFAIGAAAEGMKPVAEIQFADYVYPAFDQIVNEAAKFRYREGGTGINVGGLVIRMPCGAVGHGALYHSQSPEALFAHVPGVRVVMPRSPAQAKGLLLSSIFNHNDPVIFMEPKILYRAAVEHVPNEYYTIPLSKAEVIKPGKDLTIISYGQPLYLCSSAISAIEKTMKGVSIELIDLRTIYPWDRQTVIDSVRKTGRAVVVHESMINYGVGAEVAATLQEGAFLRLEAPVKRVAGWSTHTGLSYEQFILPDVARIYDAVKQTLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKE1</accession>
    <name>A0A9W9WKE1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_009402</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785719.1">
        <property type="nucleotide sequence ID" value="XM_056938997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKE1"/>
    <dbReference type="GeneID" id="81629247"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="20"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5466673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="329" mass="36172" checksum="31596DE74427B726" modified="2023-11-08" version="1">MSDPPRDLLDGISGALASEGDVFQMILITFIGLSCYNIAELVVLVLSTFRRWRGLYFWSLLTSGCLGVIPYSIGFLMKFFTPTDSILSVTILTIGWWTMVTGQSVVLYSRLHLVLRDENILRRVLYLIVANVFLLHIPTTILTFGANIVHSGAKPWVDGYNVMEKIQLTGFTIQESLLGTLYVIEAVKLLRLGADVTARPYARSIMYQLIGINCAIIAMDLMLLVLEYANFYAVQITLKGFVYSLKLKLEFAVLGRLVDLIQGSRQPLSLVLADTLPLCLMQTASASPSRGAGDSSFRPESKETMSTTDGARIVEGRAIVEIGAGISGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKE9</accession>
    <name>A0A9W9WKE9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extradiol ring-cleavage dioxygenase class III enzyme subunit B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_009366</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785683.1">
        <property type="nucleotide sequence ID" value="XM_056938961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKE9"/>
    <dbReference type="GeneID" id="81629211"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF1">
        <property type="entry name" value="AROMATIC RING-OPENING DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G00640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="6"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5466637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="287" mass="32263" checksum="A2EB71811471EBB6" modified="2023-11-08" version="1">MGLTPVHFFSHGSTMMLGEESESADYWKKCGDEALARNIKGVIIMGAHWDCLGDKIEVSTNPNPGKSPVAYVNPEKYINYKLNPDLVTTERCIQMLAKEGFNVSGNDKFDWIHDVYLILIRMFPGGCPPTVLVSANARYDPHFHLKMGSTLRPLRRENYLIIGTGGAVHNLYRNKWAPMVRFRDNFAMETPPEDWAMEFRQAVEDVITKTSGPQLRRAMTRLMKHPRFRDAHATDDHFMAALFVAGAAGEAEDEEAPGVLGAESWELTNMCNSQFTIGQWSKPPIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL56</accession>
    <name>A0A9W9WL56_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785778.1">
        <property type="nucleotide sequence ID" value="XM_056939056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL56"/>
    <dbReference type="GeneID" id="81629306"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5466732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="26915" checksum="84130E6BAE589620" modified="2023-11-08" version="1">MPTDSEDEALFASLAAEEASSYRDTRIQQLNAEFASSKTNRTTDSSSTTTTTPFTLAHQSPTYPTLSTDQSVLDHTTSSTRSIIHFSHPDFARCDVMDAALARLAAAHHEVRFARVDVRNTPFLVEKLGIRVLPCVIGFRDGVGVERVVGFEGLGERGFDAVGGGFRIGVLERRMVGKGVFEEVRVGDGEEAGSEGEDGDEDESDDGERRRNGLMGRVGKAKPKGRSIRSGRVRRGMDEEDDDDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL60</accession>
    <name>A0A9W9WL60_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein L25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_009475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785792.1">
        <property type="nucleotide sequence ID" value="XM_056939070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL60"/>
    <dbReference type="GeneID" id="81629320"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000035">
        <property type="entry name" value="60S ribosomal protein L23a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005633">
        <property type="entry name" value="Ribosomal_uL23_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011118">
        <property type="entry name" value="PRK14548.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03939">
        <property type="entry name" value="Ribosomal_L23eN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL23 N-terminal" evidence="7">
        <location>
            <begin position="11"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5466746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="149" mass="16477" checksum="FF65E76697D590B8" modified="2023-11-08" version="1">MAPTTKQGNASRANAAAKAVVKGSSLHKARKVRTSTTFHRPKTLQLSRSPKYPRVSVPRDPRMDAHNIILYPLNTESAMKKIEENNTLVFIVDVKANKRQIKQALKKLYDVDTVKVNTLVRPDGSKKAYARLTADVDALDIAATKLAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLA8</accession>
    <name>A0A9W9WLA8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ran GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_009223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786195.1">
        <property type="nucleotide sequence ID" value="XM_056938818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLA8"/>
    <dbReference type="GeneID" id="81629068"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5469605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="419" mass="45532" checksum="7101F9D0DEC823A9" modified="2023-11-08" version="1">MAPPKVFSLEGKGLKLDTAEDIEAHIKPLSESTDFTEIRFGGNTLGVGASERLAQALATQRSLEVADLADIFTSRLLSEIPPALKSLLDALLEIPSVHTVNLSDNAFGLNTQAPLVDFLSRHVPLRHLILNNNGLGPAAGVLIADALSRLAERKEEARKEGKEVAMLESIVCGRNRLENGSMEAWARAYEKHAAGMKSVKMTQNGIRQEGVSHLLKNGLRHCGALEVLDLQDNTFTVTGSTALAGVLEGWTALIELGVGDCLLSARGGVKVAQALAANKNQKLQILRLQFNEIKAEGVKALAHAAKTALPSLRRVELNGNIFSEDDPNVIELRELLEARQEEHGTDDDSEDTWGLDELDELEEEDSEDEAEDEEDEDEEVQAKAEKTLEDADRAEQEKVSQKSDKDVDELADVLGKTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQV4</accession>
    <name>A0A9W9WQV4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786563.1">
        <property type="nucleotide sequence ID" value="XM_056938181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQV4"/>
    <dbReference type="GeneID" id="81628431"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5472017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="110" mass="12538" checksum="C9E5757BA36BD545" modified="2023-11-08" version="1">MQLISRLDSPITQALRAYIDSTIRRKVKHLVSEAKQKSEQYFEKAMDTLLEESSGRLYDLIQGAGSGLRDQADDCMVEIKDTTTEGLEELKEETQEQTEAMDDYSTERVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WSZ8</accession>
    <name>A0A9W9WSZ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5474966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786724.1">
        <property type="nucleotide sequence ID" value="XM_056937632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WSZ8"/>
    <dbReference type="GeneID" id="81627882"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5474966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="126" mass="13765" checksum="5945178B2138A94E" modified="2023-11-08" version="1">MTNGVHAITSRYFALRSIVYDIVSQSQSLFLSFKLDGPTAQVNKLVSALGTTVALNDAWILLLQKFWYPRTLAHAGQPGHIELEDSAKMPGKVKPSMSEAKTLCTRAKVNAIGLQLPLNQPEISAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTI2</accession>
    <name>A0A9W9WTI2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787005.1">
        <property type="nucleotide sequence ID" value="XM_056937913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTI2"/>
    <dbReference type="GeneID" id="81628163"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="385" mass="42337" checksum="20AEEBC60D2EB3F2" modified="2023-11-08" version="1">MAGALNSAPRSSNYTTESSWIDQSVWRPWLGSNPHSCLDPDPDSDLTTGFNTRSTCRLDSGVSSCWAGGYDDDLDPALKSRSNSGLARYSNRDLNQRLSPDSDSSLRRSNSDVHNSLASALDPGVIMVRVQRQTFELPMMSEESFQQTTTFSDNVSARSNEGWLEASRPDAMSRGGILLTWAEEKDKQQGYDFTQADASRFRAHREDSPPVDSAAVVSLLTDTSFDPAFGGTEEIDLDPAAAPPLLTRSEMEMLNSFRKQIGRSSDRASTTASSQAGLSGLSLIPDIDSFLQQNDSSTLRRQGMQATAQPSLTLSDSVLEHRRGAVDWVTVHKRYHDEIWGYLRPALEAAKEEMEEKGQEGLTGGEDTDGPAVRRLKVILRHVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTK4</accession>
    <name>A0A9W9WTK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endosomal/vacuolar adapter protein YPT35</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PX domain-containing protein YPT35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_008192</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YPT35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786884.1">
        <property type="nucleotide sequence ID" value="XM_056937792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTK4"/>
    <dbReference type="GeneID" id="81628042"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07280">
        <property type="entry name" value="PX_YPT35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037917">
        <property type="entry name" value="Ypt35_PX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="239"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5475126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="282" mass="31037" checksum="F6BC59036A24D052" modified="2023-11-08" version="1">MESVIEETAPTPAAAVLPQPVSKLSLATTPNTIDNGHAEDISSAKAGLAGDNQLHEDHKVNEIQSSQDGGDKGTLTLQNGHLEHTAPSPINSPAPSSKSSRPVSGIIPPFWQRHERTVSRASLSSIAQSRIIRLEDHTADPNSETSRGLWAKSVAIDDHVVVQGKSGIGSYVVWNCTVQTLDGGPIVVRLRISTDLQLDTLNLMTFGKDLHQPFLMPEMHYRRFLPRVYYKINISSDTTVKFRPKFLETRRVGLEYFLNCVLLNPEFSSSPIVKDFLFGRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU78</accession>
    <name>A0A9W9WU78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_007894</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787360.1">
        <property type="nucleotide sequence ID" value="XM_056937495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WU78"/>
    <dbReference type="GeneID" id="81627744"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14334">
        <property type="entry name" value="UBA_SNF1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000407">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000069">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000236">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013896">
        <property type="entry name" value="SNF1_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08587">
        <property type="entry name" value="UBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="76"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="430"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="516"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="696"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="702"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5475607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="802" mass="90636" checksum="C468246B1BCE76F1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU84</accession>
    <name>A0A9W9WU84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_007913</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787379.1">
        <property type="nucleotide sequence ID" value="XM_056937514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WU84"/>
    <dbReference type="GeneID" id="81627763"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5475626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="92" mass="10732" checksum="1089F04D75440578" modified="2023-11-08" version="1">MTVTESVKNLVGLGEASATRKEMSEARLPMQYRDSCAHLLIPLNRCRQAEYYLPWKCETERHSYEKCQYDEFKKRVAKMDELRAAKDGARSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUD2</accession>
    <name>A0A9W9WUD2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_007969</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787435.1">
        <property type="nucleotide sequence ID" value="XM_056937570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUD2"/>
    <dbReference type="GeneID" id="81627819"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000002">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02006">
        <property type="entry name" value="IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="111"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5475682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="510" mass="55547" checksum="237CD24250FE5DBA" modified="2023-11-08" version="1">MSAAGPAAWRHASRACSRRLPAPGAFATPRRSLATGLRGARTYVTETKAGQAQVNVDTAIKDEQKSFMKQTGVAPSTATLSASGMSADAAMSPAAGVLKQATVMDQGTRPMYLDMQATTPTDPRVLDAMLPFLTGIYGNPHSRTHAYGWETEKAVEEAREHVAKLIGADAKEIIFTSGATESNNMSLKGVARFFGRSGKKKHIITVQTEHKCVLDSCRHLQDEGFEVTYLPVQSNGLVRMEDLEAAMRPDTAIVSIMAVNNEIGVIQPLEEIGKLCRSKKIFFHTDAAQAVGKIPMDVNKMNIDLMSISSHKIYGPKGIGACYVRRRPRVRLDPIISGGGQERGLRSGTLAPHLVVGFGEACRIASQEMEYDHKHISRLSKRLSDSLLGLEHTTLNGDPVAHYPGCVNISFSYVEGESLLMALKNIALSSGSACTSSSLEPSYVLRALGSSDESAHSSIRFGIGRFTTDAEIDYVLKYVHERVEKLRDISPLWEMVQMGIDLKTIQWSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUG9</accession>
    <name>A0A9W9WUG9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_008001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787467.1">
        <property type="nucleotide sequence ID" value="XM_056937602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUG9"/>
    <dbReference type="GeneID" id="81627851"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="305"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5475714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="752" mass="83758" checksum="F010803DACCF8EFA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVJ4</accession>
    <name>A0A9W9WVJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787991.1">
        <property type="nucleotide sequence ID" value="XM_056937192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVJ4"/>
    <dbReference type="GeneID" id="81627441"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5477447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="231" mass="25469" checksum="66C6FB9F76EB745B" modified="2023-11-08" version="1">MHALIIGGSGRTGKLVVEELLKREHRVTALIRNPTSMKDFGRIDVVKGISFLSVQLHSLRSPTELADVRQAFAHRVPDVVVVTLNSPRASESPFAAPVSPPRLMADSNANVVTAMKEFGVKKVVIMQAFGVGASWPNMACLLRVLMSKTNMSYTYDDHNMTDQEVRESGVTYVMVRPSRLVETEIETVKEWPENGKGVPMMASTSRKSVARFLVDAAETSRWDNTAPVISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVU5</accession>
    <name>A0A9W9WVU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyltransferase sidL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_007619</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lysine N-acyltransferase MbtK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788019.1">
        <property type="nucleotide sequence ID" value="XM_056937220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVU5"/>
    <dbReference type="GeneID" id="81627469"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438:SF1">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13523">
        <property type="entry name" value="Acetyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="368"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5477475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="539" mass="60939" checksum="E1B2F7B64B5A6250" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1I2</accession>
    <name>A0A9W9X1I2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_006580</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
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            <end position="211"/>
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            <end position="463"/>
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        </source>
    </evidence>
    <sequence length="881" mass="98672" checksum="9536DF263CB2A786" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2A1</accession>
    <name>A0A9W9X2A1_9EURO</name>
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        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">N7539_006656</name>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="310"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5480762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2E2</accession>
    <name>A0A9W9X2E2_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">N7539_007049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
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            <taxon>Eurotiomycetidae</taxon>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5481155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701:SF1">
        <property type="entry name" value="UP-REGULATED DURING SEPTATION PROTEIN 1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5481155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="616" mass="66315" checksum="408447A99CA7BC9F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2Q0</accession>
    <name>A0A9W9X2Q0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_006961</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788497.1">
        <property type="nucleotide sequence ID" value="XM_056936562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2Q0"/>
    <dbReference type="GeneID" id="81626811"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5481067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="115" mass="13120" checksum="A42C3D3D3A4C6169" modified="2023-11-08" version="1">MSAQNSAGIQTLLDAEREAQKIVQQDRTKRIRDAKAEAQKEIEEYRNQKEEEYKKFETEHSSGYRKAEEDADKEAQEKLKEIEAAGKKQGDKVVDDLIQATTDVKPKVPEKIAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X304</accession>
    <name>A0A9W9X304_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_006357</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the epsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788883.1">
        <property type="nucleotide sequence ID" value="XM_056935959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X304"/>
    <dbReference type="GeneID" id="81626208"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16991">
        <property type="entry name" value="ENTH_Ent1_Ent2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000010">
        <property type="entry name" value="EH domain binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF110">
        <property type="entry name" value="EPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ENTH" evidence="12">
        <location>
            <begin position="10"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="156"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="285"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="445"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="558"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="325"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="445"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5482911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="585" mass="65559" checksum="7F1C6C4FF417024B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5F2</accession>
    <name>A0A9W9X5F2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mediator complex subunit 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MED11</name>
        <name evidence="6" type="ORF">N7539_005776</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Mediator complex subunit 11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5F2"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019404">
        <property type="entry name" value="Mediator_Med11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22890">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10280">
        <property type="entry name" value="Med11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5483980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="260" mass="28183" checksum="8A7561CD6B770439" modified="2023-11-08" version="1">MMLRMVERAESGRAGATNVACVRFKCEFDMRRAARSASSPRKLFCVETSYAPIRQVQTVQQARAKEFSFSKLHKPLSVLLIMAVASQSTDKIFTSADRIRQLNEIDKDIAQVIQSAGLAIQALTNNQPDHDNSMTGSLEAHKRQFKEAVAKYFALVSSVDVRLRRQIYALEEESLGQGLAGKPGDPSGAGVGSAGSIGAGSGAANPLDVSWLNSRKDTVGMDKEAELWFEARDFVERLAGTPSGELAPNNSVASTEMQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5J1</accession>
    <name>A0A9W9X5J1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_004703</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789499.1">
        <property type="nucleotide sequence ID" value="XM_056934305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5J1"/>
    <dbReference type="GeneID" id="81624554"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000258">
        <property type="entry name" value="Flavin-binding monooxygenase-like protein (AFU_orthologue AFUA_6G01900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5484715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="603" mass="67594" checksum="08DCA21CD3D65009" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5K8</accession>
    <name>A0A9W9X5K8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789516.1">
        <property type="nucleotide sequence ID" value="XM_056934322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5K8"/>
    <dbReference type="GeneID" id="81624571"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586:SF21">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE (PLP)-DEPENDENT ASPARTATE AMINOTRANSFERASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="1">
        <location>
            <begin position="25"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5484732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="406" mass="44560" checksum="DBB58B3D745F8D23" modified="2023-11-08" version="1">MVAMASTFDVTAARAAFPALKNEQIFMDNAGGSQVLGTVADSIHSYLLKNNVQLGATYETSKSSTAAYDEAYKAAAGFINAHPDEISIGVSTTQLFQNLSTALKFRPGDELIISKLNHEANSAPWVRIAERLGLTVKWWAASDPKNPQCDVSDLQTLLSDKTRLVAMPHVSNITGTISHVRKIADAVHAYSRALLCVDGVALAPHRQVDVKALDVDFYGFSWYKVYGPHIAQLYASSRISDQIESLAHFFKSGESLDLKLNLASVNYELAQSIPEVVAFFGDDPRATWAAMVAHEERLQEILLRFLTSDDRITIIGETSANQEARVPVISWVVRGIKSQRLVEAVEARSAYGFRSGHMYSHRLLKDVCGFDDVDDGVVRVSLLHYNTETEVVGLVSVLKEALAELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5Q7</accession>
    <name>A0A9W9X5Q7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_004808</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789604.1">
        <property type="nucleotide sequence ID" value="XM_056934410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5Q7"/>
    <dbReference type="GeneID" id="81624659"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF86">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="276"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5484820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="646" mass="72077" checksum="66F5EE77531443D8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6A5</accession>
    <name>A0A9W9X6A5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_005096</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TIM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789892.1">
        <property type="nucleotide sequence ID" value="XM_056934698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6A5"/>
    <dbReference type="GeneID" id="81624947"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.320:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5485108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="232" mass="26558" checksum="784B0CF6AE3D58D0" modified="2023-11-08" version="1">MNAQCLRTLKPALQSAPLALRLTTRRELARHYATQTGPRPKRRNITVLSDDGRYEWGELSGREKVSRATQQSINFVVVIAGAVLTDLECSQGGVFYLFWTDVVSPNSRTWQYEKAVERVKEDPRCIQLLGDRREIRAFGETTNSRWARNRPIASTIEKDRLGREHLRMNFNVEGPLNTGVVFVHLMKPLDKDEWEYQLLALDVKGHSRIILEKAAEKPGVASSLKLFGIQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6C0</accession>
    <name>A0A9W9X6C0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_004884</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789680.1">
        <property type="nucleotide sequence ID" value="XM_056934486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6C0"/>
    <dbReference type="GeneID" id="81624735"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5484896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="672" mass="75457" checksum="CA6B70CF18DAD023" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6F9</accession>
    <name>A0A9W9X6F9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_005002</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789798.1">
        <property type="nucleotide sequence ID" value="XM_056934604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6F9"/>
    <dbReference type="GeneID" id="81624853"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001834">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF152">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="35"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="249"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5485014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="528" mass="58999" checksum="EAF9E0BAB60C4A81" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6M9</accession>
    <name>A0A9W9X6M9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790046.1">
        <property type="nucleotide sequence ID" value="XM_056934852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6M9"/>
    <dbReference type="GeneID" id="81625101"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="18"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5485262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="412" mass="45502" checksum="9DCB6337A6634215" modified="2023-11-08" version="1">MDVTFITIHGKSGCLQDLSRDASILYASDSIQVVLGYQPQEVLNRSCWDYFHPKELQFARSVHGRGVRLDKAAVLNYCSIRHKNGSWVGCECVFTVVYDVLIASTTIYGQGRGSQKRAIDAPIVRQLFDSSPHDPRYHMLTLLSDKFSRRLAEPLHEPRAALFVNRFTRTATIMYATSGVTEILGLQPHQLVSKSFFYCIQERCLRDAVRCLESAKANDSIAYLRFWFRNPLLDEDVDMDTGGHADPASGTNNEFSARAGPPIELEAVVSCTSDGLVPVPVYSNGIFAAPWALEPVYAYGTASYPADGCVNTAYPEAKTTLCRENEISPLGLGATIAPTQNYSSRQLPHPAASTKTGLTRGPQENLLMDTIRDVAVFAWGIVGINRSLEQHKYGSPSGNAHPDVTMDETWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6Q2</accession>
    <name>A0A9W9X6Q2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_005290</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790086.1">
        <property type="nucleotide sequence ID" value="XM_056934892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6Q2"/>
    <dbReference type="GeneID" id="81625141"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5485302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="232" mass="25306" checksum="59D4519BC445835C" modified="2023-11-08" version="1">MSSSKNPPTIRPSGPTGLTRGYLFTYNTANLLAWGACLVYTASLVPEALATKSIPSIFHATFNPLLLATQSLALLEVLHSLVGIVRAPFVTTAMQVASRLLVVWGILAQFGGDIVGAKSEQLGDYAYLGCVAAWGITEVIRYGFFAITLSGGSVPAWWTWLRYNTFYVLYPIGITSECTLIFKALGPAGAVDPLFQYFLIAVLVIYVPGSYILYTHMISQRRKVLRGKKRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XC33</accession>
    <name>A0A9W9XC33_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790673.1">
        <property type="nucleotide sequence ID" value="XM_056933132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XC33"/>
    <dbReference type="GeneID" id="81623381"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF3">
        <property type="entry name" value="FUCOSE-SPECIFIC LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="290" mass="31253" checksum="556095311AEB904B" modified="2023-11-08" version="1">MPLDGASFTPLNLPPTFTLPRCLEYFELTAGPNTDLWRKPPNGDTSTAPIVFTSLRHPFVVAEVTVSADWEMEWDQGGLVIFAGATPQSLSSNARNGFSSTRRSIADRTTLASSLPPSTTPTTTTSTTTSPPRSSPLPCKWVKAGMEFSSGTLNASSVSATADGADWCVSPLGPAMMNSSGGGWTIQSLRIKLERVGHALWIWYQVPLAAPYATTPGAVGSTWKKLREVTWFFYGVEDKFVHVGVYASRPTNVARGQTMWDAMHGLTLDSTLAAGPTDGLVVEFEDLEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCJ0</accession>
    <name>A0A9W9XCJ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_003443</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790586.1">
        <property type="nucleotide sequence ID" value="XM_056933045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCJ0"/>
    <dbReference type="GeneID" id="81623294"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43039">
        <property type="entry name" value="ESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="307"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5488553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="553" mass="61751" checksum="652512F7067EAACB" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCL0</accession>
    <name>A0A9W9XCL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Autophagy-related protein 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_003815</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the PI(3,5)P2 regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790958.1">
        <property type="nucleotide sequence ID" value="XM_056933417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCL0"/>
    <dbReference type="GeneID" id="81623666"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000965">
        <property type="entry name" value="Autophagy-like protein 18 Atg18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="262"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5488925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="427" mass="46211" checksum="408DA6F2F401894F" modified="2023-11-08" version="1">MAMNFVTFNQDYSYLAVATSKGFRIFTTDPFAKSYETKEGNIAVIEMLFSTSLVALILSPRRLQITNTKRQSTICELTFPTTVLSVKLNRKRLVIVLEDQIYLYDIQTMGLLSTIDTSPNPHAICALAPSSENCYMAYPLPQKAPTTIKQPAHAPPGTSHVSPTTGDVLIFDAVKLEAINVIEAHRSPLACITLNSDGTLLATASDKGTIIRVFSVPDGHKLYQFRRGSMPSRIYSMSFNTTSTLLCVSSSTETIHLFKLTQQGPTSDGSSAHSPVGRDSQSASSLYGHHDDDENNGESSADLAARKHNGTLMGMIRRTSQNVGGVVAAKVGGYLPKGVSEMWEPARDFAWFKLPRSAQSTGSGGSNGPLRSVVAMSSNTPQVMVVTSDGNFYVFNIDLSKGGEGTLTKQYSVIDSVDKLGHPSVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCM3</accession>
    <name>A0A9W9XCM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_003805</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790948.1">
        <property type="nucleotide sequence ID" value="XM_056933407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCM3"/>
    <dbReference type="GeneID" id="81623656"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000121">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="253"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="173"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="579"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5488915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="627" mass="68799" checksum="065DF92E336DFAD6" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCX2</accession>
    <name>A0A9W9XCX2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_003623</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790766.1">
        <property type="nucleotide sequence ID" value="XM_056933225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCX2"/>
    <dbReference type="GeneID" id="81623474"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5488733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="566" mass="61513" checksum="FBA75632D235C6A4" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XD17</accession>
    <name>A0A9W9XD17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_004040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791183.1">
        <property type="nucleotide sequence ID" value="XM_056933642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XD17"/>
    <dbReference type="GeneID" id="81623891"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5489150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="64" mass="6768" checksum="3CC15697153947CB" modified="2023-11-08" version="1">MALTDCVSLFLGSRSRLISLDLIVVLSRGTAIAGYTRRSTLGAKGLPDEELISRTSASLLASDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDA0</accession>
    <name>A0A9W9XDA0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MutL protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003818</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790961.1">
        <property type="nucleotide sequence ID" value="XM_056933420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDA0"/>
    <dbReference type="GeneID" id="81623669"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03483">
        <property type="entry name" value="MutL_Trans_MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000033">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="270"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="696"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="712"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5488928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="783" mass="85747" checksum="C1D607BCE25095A6" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDF6</accession>
    <name>A0A9W9XDF6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pre-mRNA-processing ATP-dependent RNA helicase PRP5</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Pre-mRNA-processing ATP-dependent RNA helicase prp5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_004235</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791378.1">
        <property type="nucleotide sequence ID" value="XM_056933837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDF6"/>
    <dbReference type="GeneID" id="81624086"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17953">
        <property type="entry name" value="DEADc_DDX46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22474">
        <property type="entry name" value="KH-I_PRP5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="576"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="781"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="268"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="434"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="942"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="24"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="173"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="954"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="986"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5489345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1184" mass="130574" checksum="9BBFB4D7D4EDC59C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDH7</accession>
    <name>A0A9W9XDH7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar iron transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_004265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5489375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="252" mass="27243" checksum="C9357E44EB824233" modified="2023-11-08" version="1">MSLPRTEPRIELPRVTHAASERHSDLGDIIRDITIGFADGLTVPFALTAGLSSLGSSKIVIVGGLAELFSGAISMGLGAYLAAVTDRDHYSSEEAREREEVLTKPGAEQEECLEILDGYGISREASQSVVDCLTRDPEQWIRFMMDFELKLEKPNVSRAWISAATMGLSYFIGGLLPMIPYFAMKNTTHALFISIGITIVVCILFGFLKNFAIIKTKRAGFYGAAQTLIVGAIAAGTSYGIVYGVDHSNIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE43</accession>
    <name>A0A9W9XE43_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_004078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791221.1">
        <property type="nucleotide sequence ID" value="XM_056933680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XE43"/>
    <dbReference type="GeneID" id="81623929"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5489188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="92" mass="10491" checksum="CBD6CFCB346AC398" modified="2023-11-08" version="1">MTMNMFEPSAIKVKDMRDPGSTSIELHVKVETAEGTDLPEISDERLPRGQQGLTFSIESILRLKTFYSLSPFPTVPGQKFSQKRVQYVLKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEB4</accession>
    <name>A0A9W9XEB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_004358</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791501.1">
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    </dbReference>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
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        </source>
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</entry>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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            </authorList>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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            <dbReference type="PubMed" id="36726175"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792154.1">
        <property type="nucleotide sequence ID" value="XM_056932195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEY9"/>
    <dbReference type="GeneID" id="81622444"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581">
        <property type="entry name" value="MRG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581:SF5">
        <property type="entry name" value="MRG_MORF4L-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5491025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33734" checksum="7C79BA765D3B3A6C" modified="2023-11-08" version="1">MPPRKKVKRAHSITPPEDTTAQSRGETPGSNDLAEKPEAAYDLLADPWTDDQETALLKAIIKWKPVGVHKHFRMLAIAEYLKSQGYAPSSAEHMRIPGIWKKLGTLYNLEALDEREDAIFADSNEDDEEPSEMYWPFELPYDEYGDLMFERRLATEGSLSPVTSRHVESRRGSTVADTDEPRSSPVPSRGRRYTRGTRRPTRETRSTRLQVEIGSGSQGKTSDEDLESSQESGANDEGQDDGGEDGSDIGKDSDGDEGEEAEEEEETSDKGGTRSTRAKASRTKPKGTKKAPASTGTRRTGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFB3</accession>
    <name>A0A9W9XFB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_002796</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792358.1">
        <property type="nucleotide sequence ID" value="XM_056932399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFB3"/>
    <dbReference type="GeneID" id="81622648"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="15"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5491229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="515" mass="56558" checksum="E4C4294290CE2AE2" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFK3</accession>
    <name>A0A9W9XFK3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792366.1">
        <property type="nucleotide sequence ID" value="XM_056932407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFK3"/>
    <dbReference type="GeneID" id="81622656"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052907">
        <property type="entry name" value="Beta-lactamase/esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319:SF3">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="15"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="385" mass="41317" checksum="7CAF9200B9200C5F" modified="2023-11-08" version="1">MTELHGHCDSAFNAVRALFRERLESGAEIGASLCINIDGKNVLDLWGGFANEARTRPWERDTVTGVWSSSKVVTCLAVNILADRGLLDVNEKVSTYWPEFAANGKENVKVSHILSHTAGVPAWAPGITLEEILDVEGATKKLAELAPMWTPGEFSGYHLVSQGHLLGEIVRRVSGKSLTQFIADEIAGPLGADYHLGLPEADWPRAADLIPPTESRMPQIDPASIAARAFAGTPMGAAFANSPNTPEFRKQELGAIGGFTNGRALARIGAMVSCKGTVDGKQILSPGAISSMLQEQAAGTDAVLMTYLRFGLGVGLPVPQSLPVIPEGNICFWGGWGGSLILMDLDRRMTIGYAMNKMYPTVVGSEETTHRYIKAIYEAVNQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG04</accession>
    <name>A0A9W9XG04_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucosamine-6-phosphate deaminase</fullName>
            <ecNumber evidence="3">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_003111</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792673.1">
        <property type="nucleotide sequence ID" value="XM_056932714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG04"/>
    <dbReference type="GeneID" id="81622963"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000002">
        <property type="entry name" value="Glucosamine-6-phosphate deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF5">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="10">
        <location>
            <begin position="86"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5491544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="418" mass="46411" checksum="7E45586BA490061D" modified="2023-11-08" version="1">MFNKQRGKRQINTSLVAWPTPELPPRHGCMSCCNSRRVIIREDPHTASLYIAEYIVISSFAALNRPSTDPFFFFLSGRIKAFKPTESQPFVLGLPTGSSPEIIYKLLVQRHRAGEISFKNVVTFNMDEYVGLPRDHPESYHSFMYKHFFSHVDIPPQNINILDGNAPDLAAECASFEARIAGYGGIELFLGGVGPDGHIAFNEPGSSLASRTRVKTLAYDTILANSRFFDNDVSKVPRLAMTVGIQTIMDSREVVIVATGAHKAFAVQKGLEDGVNHMWTLSALQLHPHPLIVCDRDATLELKVKTVRYFESIEQAGTDARTQGPPLVYRPRTYVPAPVSAEKKRVSPRSAPAPDRTPVKVPKDLRINTDFNRTLDEDELTPDSMSSRMVDSAIGGLDETLKKDLVFDRMGARVAAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGA1</accession>
    <name>A0A9W9XGA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_002795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792357.1">
        <property type="nucleotide sequence ID" value="XM_056932398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGA1"/>
    <dbReference type="GeneID" id="81622647"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5491228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="27433" checksum="0E2D70EBC4C15939" modified="2023-11-08" version="1">MTTYVLYSPDGAINEFFNSNTTVTRKQCDEFAISRAGGVSTALQMQGVCSYTVTAGPNNSKLFQFRDENSVIDMGNISLAKTVHPDFVASCKYLGTMGDSRPVYVYEMEHLTGTAHIIARIPPEDMLRQRNTIKDFASFNQIFDLLARNLLSRFAPNLDMVRKELPALFSKALPCVLSYGDLNMMNLLVNPKTGNIIGIVDWAELRILPFGFALYGLENLLGRMDSEGWRYYDGYRELESLFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGC7</accession>
    <name>A0A9W9XGC7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General amino acid permease AGP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003327</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792888.1">
        <property type="nucleotide sequence ID" value="XM_056932929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGC7"/>
    <dbReference type="GeneID" id="81623178"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF6">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="51"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5491760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="585" mass="64302" checksum="8F18BCF65C569BFB" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGK6</accession>
    <name>A0A9W9XGK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Aspergillaceae</taxon>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792356.1">
        <property type="nucleotide sequence ID" value="XM_056932397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGK6"/>
    <dbReference type="GeneID" id="81622646"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="KAJ5491227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="162" mass="18124" checksum="A46EB142A4BE7F1D" modified="2023-11-08" version="1">MSLLAIQASCSTNARTMPNSLLLQSIAETVALPQWTWSANGTHTAKGYTTQAADETSQEGMKADCDNINLNKKISVDFRSDVFGPGLIGYFYKCEKIREDTNLYWFTISSGDAPQIDRLCDPATEFPLVFDSQHSTWWIDEPFNCAQRTSPDDQSVWEHATS</sequence>
</entry>
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    <name>A0A9W9XGN4_9EURO</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793067.1">
        <property type="nucleotide sequence ID" value="XM_056931036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGN4"/>
    <dbReference type="GeneID" id="81621285"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5492687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="60" mass="6877" checksum="CD056DA21D309337" modified="2023-11-08" version="1">MNRIYSGGQNSNYESTIDLVLISENLTDLIIKYTILGTEYGSDYYAIKTVFDALWSPLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH35</accession>
    <name>A0A9W9XH35_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_001658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793292.1">
        <property type="nucleotide sequence ID" value="XM_056931261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH35"/>
    <dbReference type="GeneID" id="81621510"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5492912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="66" mass="6985" checksum="4DDD5C980D4F3225" modified="2023-11-08" version="1">MGGGSLESGRTAGWTGGDGHDWVDMVVHRLDLFRVSGDELGHGSVASPDDLMVTVVVMDTKLKTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH97</accession>
    <name>A0A9W9XH97_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_003335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792896.1">
        <property type="nucleotide sequence ID" value="XM_056932937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH97"/>
    <dbReference type="GeneID" id="81623186"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="14"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5491768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="284" mass="30697" checksum="88C5C930CA6E3EB1" modified="2023-11-08" version="1">MSNPTINKVAIFGVTIITRAESTSTFPRGLPVIRIRYTLEDLTTALAGQDAAICAVGPGGVDSQVTMIEAAEAAGVKRFIVNDFGWGPDYRSLPEFRAPHLRRRAGWDCARAKAETNPNFTFTGITSGNPIDWAIKKFPLMGFDIAQSSATIYDTGTENFTGTTLAGIGQSVVGVLQHPSETSNRFVKVLSIKTNQNELLEAFQRSTGQEWSVRHASVQDVAQKGRQKFQAGLGGWALEMVVAQMYDEGQARCVVAPSWEESDAPLLGVENETAEGVVAKVLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHE5</accession>
    <name>A0A9W9XHE5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792790.1">
        <property type="nucleotide sequence ID" value="XM_056932831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHE5"/>
    <dbReference type="GeneID" id="81623080"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="73" mass="8686" checksum="05B079EFE40D1F44" modified="2023-11-08" version="1">MDNASFHHTERIGQLCAAAGVKLVYLPPYLPDLNPIEEFFAELKGFIRRNWSYFEDDPDREFNSFLQWCIDMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHW4</accession>
    <name>A0A9W9XHW4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_001676</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cell membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793310.1">
        <property type="nucleotide sequence ID" value="XM_056931279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHW4"/>
    <dbReference type="GeneID" id="81621528"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5492930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="548" mass="60326" checksum="EC010560272D3FDF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XID3</accession>
    <name>A0A9W9XID3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3752 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793834.1">
        <property type="nucleotide sequence ID" value="XM_056931803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XID3"/>
    <dbReference type="GeneID" id="81622052"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3752" evidence="2">
        <location>
            <begin position="89"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5493454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="241" mass="27007" checksum="AE91AF9565448944" modified="2023-11-08" version="1">MDTSEKRKLDNEAGHDEPSTKKRVIGPAMPPPQAASNPRDDGDRAPASESNSDSDSDDDFGPVVTTHASSQKSETQTKDTQRDEWMLQPPSSSDWASKIDPTQLRNRKFQTGKSARAPGSKQLDAAWVESPEERMRRLQDQVMGVGPAPNRPEQRPSTTKDAARAKEMEDRIKQYNEIKGKNVPLDKERMSRKEEEDDPSARAFDREKDMALGSKITGKQRREIVSKASDYGSRFSKGNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XJ80</accession>
    <name>A0A9W9XJ80_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1776-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_002115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793749.1">
        <property type="nucleotide sequence ID" value="XM_056931718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XJ80"/>
    <dbReference type="GeneID" id="81621967"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013952">
        <property type="entry name" value="DUF1776_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF1">
        <property type="entry name" value="3BETA-HYDROXYSTEROID DEHYDROGENASE DHS-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08643">
        <property type="entry name" value="DUF1776"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5493369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="47604" checksum="0DD0A02952ECC6E8" modified="2023-11-08" version="1">MTSDDQFFFDYLASIPHDVRRYSLQVADSIDRQFDRAAVVIRETLGQQGWLPASVRPAVRTREIRAASTGLSDRIQDWVTRHRALSSALVAFVGTGCVLLYGSKKLNGKRRKARRAGNGSRKEVVVVSGSPHEPMTRAIAADLERRGYIVYVTVSSADEEIVVQSEHRADIKPLWLDLTTTASNSSDLHPSLHELRALITQPQYPVPGVAPHTCQLSGVIIVPSPNYSAGPVATIPASSWADTVNARILSPILTAQIFLPLLTLRSNSSALIFAYPSISSSLSAPFAGPEVTTVRALSGFAASLRQELALLEKGNVDVVELRLGNIDLGPSYKPGQSQVAGTEVLAWNAQQRALYGSRYLNSVEQRPVASAGPAAIRGSSARVLHHAVLDALEPASKNIFGRRAHKSAVVYVGRGARSYSLIGDWVPSGLVSLMMGQRSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLB5</accession>
    <name>A0A9W9XLB5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_000209</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794106.1">
        <property type="nucleotide sequence ID" value="XM_056929813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLB5"/>
    <dbReference type="GeneID" id="81620062"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051668">
        <property type="entry name" value="ATG33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5495093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="189" mass="20677" checksum="3CF82794A6AC1363" modified="2023-11-08" version="1">MACPITISKFVGTVSLGLLTGLSYATTSITLPALQLLPTSITAARSFNEVKRLSRAQVLRLSSLANTCLLFAYYVSPPRRQHPFMIWMCLASTVGAFGLDIFANRHLGLKGWVCSTIRDTTCLSLGGAGHGHSNGKKEEDLVVVESEEDVNGESVREEMKMERWLQRARTWIVGVGFAMGVVGLWGDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLV8</accession>
    <name>A0A9W9XLV8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_000494</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794391.1">
        <property type="nucleotide sequence ID" value="XM_056930098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLV8"/>
    <dbReference type="GeneID" id="81620347"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="4">
        <location>
            <begin position="96"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5495378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="253" mass="27347" checksum="DB5AAE228FD0FB49" modified="2023-11-08" version="1">MGRVIRNQRKGRGSIFTANTRLNKAPAQFRTLDYSERHGYIRGVVKEIIHDAGRGAPLAKVQFRHPYKFKMINETFIANEGMYTGQFIYAGKNAGLTVGNVLPLASMPEGTVISNVEEKAGDRGALGRTSGNYVTVIGHNEDGKTRVKLPSGAKKVIKSTARGMVGIVAGGGRTDKPLLKASRAKHKFAVKRNSWPKTRGVAMNPVDHPHGGGNHQHIGKASTISRYAAQGQKAGLIAARRTGLLRGTQKTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLX4</accession>
    <name>A0A9W9XLX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha-galactosidase CBM13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_000568</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794465.1">
        <property type="nucleotide sequence ID" value="XM_056930172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLX4"/>
    <dbReference type="GeneID" id="81620421"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04081">
        <property type="entry name" value="CBM35_galactosidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18821">
        <property type="entry name" value="GH43_Pc3Gal43A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055240">
        <property type="entry name" value="CBM13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925">
        <property type="entry name" value="GLYCOSYL HYDROLASE 43 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22704">
        <property type="entry name" value="CBM13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040846806" description="Alpha-galactosidase CBM13 domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-galactosidase CBM13" evidence="7">
        <location>
            <begin position="363"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5495452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="451" mass="48737" checksum="24EE9B4CDEC0FC63" modified="2023-11-08" version="1">MYLKTAFLVAGLAWAQGALASLEIVPGATWTAGGTNQHVQAHGGGIIEENGVYYWIGENKLDGSAFQSVNCYSSTNLVEWDFVGELLSRQSSGDLGPNRVVERPKVIYNEASRKYVMWMHIDSSSYGEAKTGVATSSSVCGKYNYLGSFQPLGFQSRDMNLFKDDDGSAYLLTEDRPNGLRINRLTDDYTGVASNVYLWPDHIEAPAMFKKDGVYFMFGSQLTGWSTNDNKYSTATKLSGPWSSWSDFAPSGTNTYNSQTSFILRVGPNVMYMGDRWLSTNLMASTYIWLPLTLSGRIAKLTNEASWTISRQSAWAPGSTTTSSEAESSSNSLANGARILSCSNCSGGKSVGYLGGSSNGGIKFSSISTSSSGMTTVQIRYENGDSTQRYATVTVNGQSHILAFIPSRNGNTPSSSSLNVNLNSGNSNVISISGYQGGWAPDIDRLLVPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM73</accession>
    <name>A0A9W9XM73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_000653</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794550.1">
        <property type="nucleotide sequence ID" value="XM_056930257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XM73"/>
    <dbReference type="GeneID" id="81620506"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241:SF304">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241">
        <property type="entry name" value="TRANSFORMER-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="70"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5495537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="305" mass="33921" checksum="3A3132DB93AE0AFB" modified="2023-11-08" version="1">MADYDNDNGRYADEPRYDRDRSASPRDEPRGDRARSRSPNGRAEDSRPGPLRKAHLVEEEDEEGAQNTGSNLFVTGIHPRLTESDISRLFEKYGDVSNCSIMLDPHTKESRGFGFVNMSTAEQADAAKEGLQGEMMVVAPPRRGDRYDDRRGPMGGGGGNWRRRDDDHYRGGRYDSYNDRRDYGRDYGRDGGRGDGGYRRDYGGGGRDYRRESRDDHGYRGGPDRYGDRYSRDDRRGGDDRRGGGAGGPPPAEGGAGGGEGRGYYDRDANPPSYETAPPREPREPYSGGGRSYEGRGGDDRYGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMQ4</accession>
    <name>A0A9W9XMQ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_000973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794870.1">
        <property type="nucleotide sequence ID" value="XM_056930577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMQ4"/>
    <dbReference type="GeneID" id="81620826"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5495857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="159" mass="17606" checksum="D69CCBA776059D3B" modified="2023-11-08" version="1">MAQMSTQFILFGVKSEVEPENPASDLGEALLKVFRATKNQSGHRSSAWGRSIEEPKNIVWVIDWTDARCSINPELLKPFLVNEDKPLTAVYATLSPPISSTDTLTKNPVTELFFLPFSTAISEYESRHLHADLIKLRSVMVTQLPQAEGPCFLVNGSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMT9</accession>
    <name>A0A9W9XMT9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sulfite reductase flavoprotein component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_001022</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794919.1">
        <property type="nucleotide sequence ID" value="XM_056930626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMT9"/>
    <dbReference type="GeneID" id="81620875"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06207">
        <property type="entry name" value="CyPoR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000052">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.920.10:FF:000004">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000011">
        <property type="entry name" value="Sulfite reductase flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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    </gene>
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        <name type="scientific">Penicillium diatomitis</name>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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    </gene>
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        </lineage>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Kelch_domain_protein"/>
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        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="518"/>
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        </location>
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        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="653" mass="74383" checksum="A199806B54003C67" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN78</accession>
    <name>A0A9W9XN78_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">N7539_001208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
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                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_056930812.1"/>
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    <dbReference type="GeneID" id="81621061"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="267"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
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        <location>
            <begin position="465"/>
            <end position="529"/>
        </location>
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        <location>
            <begin position="627"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5496092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="882" mass="97465" checksum="3460BE137E24617B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJB5</accession>
    <name>A0A9X0BJB5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785813.1">
        <property type="nucleotide sequence ID" value="XM_056938436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJB5"/>
    <dbReference type="GeneID" id="81628686"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF6">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5469223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="60601" checksum="7DC2E75AA5E86F79" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJB7</accession>
    <name>A0A9X0BJB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">endo-1,3(4)-beta-glucanase</fullName>
            <ecNumber evidence="4">3.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_009572</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785662.1">
        <property type="nucleotide sequence ID" value="XM_056939167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJB7"/>
    <dbReference type="GeneID" id="81629417"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF42">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02280)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040793292" description="endo-1,3(4)-beta-glucanase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="12"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5466616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="326" mass="35461" checksum="4EB902995016476F" modified="2023-11-08" version="1">MGAMTALVATLMLWSSMALPAQAYPNYAPLQYRLRDVYDGPSFFDHFNYYSGKDPTDGYVSYVNKQSAQSLNLTYATSNTAILRVDASTPNPGPKGRQSVRIESQKAYDSGLFLFDIAHTPHGCGTWPALWMSDTLHWPQNGEIDIIESHNTGVQGNEISLHALGDCSMGGERRLTGTAVSMDCDIAVGGNAGCAVMGDSSTYGADFNARGGGVYALEIRDAGIRIWVFHRDSMPLDIANGQSPNPSSWGPPLADFPSTNCNIKSHFRNLNIIVNIDLCGEYAAMASHYTQMSGCPGSCAEFVATNPSNFNNAYWEFRSIRVYQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BM02</accession>
    <name>A0A9X0BM02_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786363.1">
        <property type="nucleotide sequence ID" value="XM_056938355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BM02"/>
    <dbReference type="GeneID" id="81628605"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.50">
        <property type="entry name" value="Insect antifreeze protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="44082" checksum="2EBF223C5A19D0A7" modified="2023-11-08" version="1">MTRSLSGQIQASSESLDSGHNGPKIEYNQPLSSPYEHPMITLCIGEKKYGVLGSHIRKYPLLGRGSPQDTYVTLSDIHRDVGHTVVHFLYSGAYETINSPLDENISYIEREYRRSVLVYHASRRYNITDLEILAKKYIENFDEAISTFEILRSAREIFSKLPDDEVWLPGYVKKVLQRSFVTGNSRFNTKDLSGILQEDWDPFSRAIMLSVIDILSSHIQCLEKGTRSQAHVASGVSKHELTSTEHPVVVDQWSIASEELPTPEECAAPEECAAAEECAAPEECAAAEECAAPEECAAAEECAAPEECAAPEECAAPEEYPVPEECPAEWHVGPNEPDAAAAGQADTKDSLAKILLPDVALYHDWETLSSVKRSKRIKRLKKKGLPIPNANGVISISLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BMT9</accession>
    <name>A0A9X0BMT9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5474970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786728.1">
        <property type="nucleotide sequence ID" value="XM_056937636.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII-related" evidence="1">
        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5474970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="112" mass="12117" checksum="A3CBD22FC07F8817" modified="2023-11-08" version="1">MASAPSAKKEFLCILPDFPGAQEKRLAVRPEHLEGVKPLVSSGEIVAGGAMLESHPAEGEPLKFKGSMMLAVAESEADVRKLLENDIYTRSGVWDLANAQIIPFKSAVRKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9X0BNC8_9EURO</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Penicillium diatomitis</name>
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        </lineage>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5475570.1"/>
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        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="88" mass="10016" checksum="7C2FBCD953E56401" modified="2023-11-08" version="1">MGKTKDWLDREYGSISPISDPQTIHFYTGNDEENQRPLMLEVSAAEEADKLEARFLLLWFFSAVCFVITGIFVLALLTARLSKDTKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNF9</accession>
    <name>A0A9X0BNF9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="81627797"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="134" mass="16078" checksum="86E205DA6828BB69" modified="2023-11-08" version="1">MIQNHRDSKIQLEQENERLKKQEAEISQKFNDSQKAKEKLERDTEELEKEIERLKKKDNERGEQAKDYLKDKAKLEKNKKDLQQDNDRLKEQQEKSAQKAKDDQKAKEELEKENEKIEAATREERPEGQRRSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNL1</accession>
    <name>A0A9X0BNL1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitochondrial escape protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_007134</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the YME2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5476990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787534.1">
        <property type="nucleotide sequence ID" value="XM_056936735.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81626984"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018850">
        <property type="entry name" value="Mt_escape_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039627">
        <property type="entry name" value="Yme2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198:SF2">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10443">
        <property type="entry name" value="RNA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="191"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5476990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="834" mass="93688" checksum="8A0019EB1C026226" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNN9</accession>
    <name>A0A9X0BNN9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787175.1">
        <property type="nucleotide sequence ID" value="XM_056937310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNN9"/>
    <dbReference type="GeneID" id="81627559"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48174">
        <property type="entry name" value="DUF946 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48174:SF5">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040740245" description="Vacuolar protein sorting-associated protein 62" evidence="1">
        <location>
            <begin position="22"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="35814" checksum="44FFDC1BCB6788EC" modified="2023-11-08" version="1">MHILLPYLAALGLLAVPTISASVTIPTYVYDYAPLVWLHSQDAYRPSDLQAQLDNTTPEVDWKPVQGAPSPLTLNNLDQLNNLGNTSVYLTSHEGIAANPQPAWLRGVTPDASGRAGNITACAIVVVDHGEGNIDAFYFYFYAYNKGDKVLGLEFGDHIGDWEHNMIRFANGTPQALWYSQHASGQAFTYGAVEKQGKRPLSYSGNGTHANYAIAGQHDHTIPGINLPVGFLLDYTDRGVLWDPTLNAWSYTYDPSTAVFTPSSPDVPAAWLDFNGIWGDDQPPGEPSIFGEAEFVAGPHGPKFKVLNRTLVCPSKPCIVLPFRIWAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BP05</accession>
    <name>A0A9X0BP05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_007554</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787954.1">
        <property type="nucleotide sequence ID" value="XM_056937155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BP05"/>
    <dbReference type="GeneID" id="81627404"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF57">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="32"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5477410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="374" mass="40854" checksum="6FCC422998BA16C9" modified="2023-11-08" version="1">MGVTFPIVKTAQREVLSVALVFSILAVAAVCLRLLAHHLARKPWTPSDYAIIIACIFAVGLQSISITGVIQAGIGYDHVTAIAAVYGLAPITKLLTLVIPLQFLWVLSLSCTKVSILLLYLRIFPVTWVVWASRATMLVIILWAIATILAGSLICRPFAFNWDQTIPGGHCGNQVQSFTATGVINLITDVFVLIIPMPLLYKLQMATYKKATLIIVFGLGFVTCIISALRIAVLSSMDFADITYTIPRANIFSGVEPCLAVILASVPLMRPLLGRSAQNSEVTAAHTRKPSEPSAASTKRCENGFLQLEDNSSQLQLRPVGTKHRVGVLAQETDRTSEESMEMTQSSPRSQDCDTKRDHGISVKQEWDVQHTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BP16</accession>
    <name>A0A9X0BP16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_007584</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 60S subunit of the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. eL40 is essential for translation of a subset of cellular transcripts, including stress response transcripts, such as DDR2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Part of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787984.1">
        <property type="nucleotide sequence ID" value="XM_056937185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BP16"/>
    <dbReference type="GeneID" id="81627434"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.50:FF:000001">
        <property type="entry name" value="ubiquitin-60S ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="13">
        <location>
            <begin position="43"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5477440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="167" mass="19089" checksum="270F6196C51BE2C4" modified="2023-11-08" version="1">MHLFPRLFSADVGFPEHIAISDYPRAIVIPLDRHIYQFEDTPFVKTLTGKTITLDVESSDTIDNVKTKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLKALASKYNCEKSICRKCYARLPPRATNCRKKKCGHTNQLRPKKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSM7</accession>
    <name>A0A9X0BSM7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_006214</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the taffazin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788740.1">
        <property type="nucleotide sequence ID" value="XM_056935816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSM7"/>
    <dbReference type="GeneID" id="81626065"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="14">
        <location>
            <begin position="65"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="343"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5482768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="375" mass="42459" checksum="7A6ED7DB093931EE" modified="2023-11-08" version="1">MDAGASTADAPSLPWRAMSSVTMWGVAGLCRGFLSALNNAEVHGGEAFTALLDSRQDASQRTKGLITVSNHISVMDDPLIWGLLPMRYWNKRWSFGSHDICFQGRPLSLFFALGQVLPTHRLAHSPFGGLGQPAITQAIRMLSKGPFPVDHHRAKPERQHFSLENVCVDPFSDLSVAYTTNGEDSHMGPSAYACNSHSWVHIFPEGKIHQSPRKTMRYFKWGIARLILEADECPDVVPMWIEGFDQIMHESREFPRFLPRVGKNVSITFGSKVDNEKEFGEMRSRWQRLKAKIEKADAQSRDLPLGVLSDELLHNKEVVELRKEVTRKIRRLVLDVRRSRGLPDEDPKEGLVETWLEEGPGREGHMKDDSWVRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSS1</accession>
    <name>A0A9X0BSS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788799.1">
        <property type="nucleotide sequence ID" value="XM_056935875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSS1"/>
    <dbReference type="GeneID" id="81626124"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5482827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="381" mass="42589" checksum="EA67BA04B2862868" modified="2023-11-08" version="1">MATAHATHRESWDSLSSTFAHLEVSFSQDSCYGSDEVSVTSNKPAPLQSSVETFVEKRSPTLHPFLKSILKTSTSDAHDASDDSESESGYGSDDIEFEYDALSEGSEDEDEDEDDNMSDFSVWEETSEVPETREDRTDTFDDDFIAFEPSVRFATDIEYIDSSDLDMADDEDTTEPQMTCHEMMMLALKAGSLSSSVLSDDHSDDDDEEQEEQEPRHAEFTRAAVTHPEDFSRDNVDVDRQLFIAYMNGIHGIADAKYKAYIQTQADNVRLGNQTESMHPDDAHCMYLDLIQSHVIGVFPNLLSTGEFDTLLELRKQNVAGLQAERTAAPLPSSPHRLLLDKVEHLLEHRLAIGRIHVLPDEMSFLAGGVIQALDAHQSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BT12</accession>
    <name>A0A9X0BT12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_006110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788636.1">
        <property type="nucleotide sequence ID" value="XM_056935712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BT12"/>
    <dbReference type="GeneID" id="81625961"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000077">
        <property type="entry name" value="LIM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000127">
        <property type="entry name" value="LIM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000113">
        <property type="entry name" value="LIM domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF8">
        <property type="entry name" value="PAXILLIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="567"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="644"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="513"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5482664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="785" mass="87113" checksum="07A5A029694F72C0" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BTB8</accession>
    <name>A0A9X0BTB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_006516</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789042.1">
        <property type="nucleotide sequence ID" value="XM_056936118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BTB8"/>
    <dbReference type="GeneID" id="81626367"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041012521" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="24"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="566"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="637"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5483070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="676" mass="74796" checksum="4BFEAB1318549990" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BTS1</accession>
    <name>A0A9X0BTS1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_006006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000007">
        <property type="protein sequence ID" value="KAJ5483806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789076.1">
        <property type="nucleotide sequence ID" value="XM_056935608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BTS1"/>
    <dbReference type="GeneID" id="81625857"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5483806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="102" mass="11704" checksum="B7B2B651B5C71CCD" modified="2023-11-08" version="1">MAALRRVRSNNSSKRKSFRQRQCRRKTNIMKKASEYSKMCDADVCISIRIRETGQIHILSADTSGFWAFLPLQLGSYYLTPTVITDRDLKKAKQDTASKDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BU07</accession>
    <name>A0A9X0BU07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_005812</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789286.1">
        <property type="nucleotide sequence ID" value="XM_056935414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BU07"/>
    <dbReference type="GeneID" id="81625663"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000007">
        <property type="entry name" value="Putative not2 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="316"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="213"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5484016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="461" mass="50188" checksum="27BAA05EA858E895" modified="2023-11-08" version="1">MSGLPAPQQAQARNTTLATGRLPNGGAANWNFNLPGTSSLQGHQQRTLGTMGSFAQSLGGSQPSSALDLSEFPSLSGTSQQSQSQNSVWANASQRAAQHTPVQRQQHPPTSQPPSRNSQSQQLLNQQSSQASHDDMLPSASQFANRLDDFRNGGQGISSQLGNGSQPRTGNIDEFPPLGRNVGNVGNVAAELVQERRASAMQAPGFGAYNSGIGSSRSPVSQGANGTLAQDKDRNFSDPQLLQQRQEQGSEVQEPATGMQSAEQPPLAQMSELDRFGLSGLLRMIHSESADVASLAVGQDLMTLGLDLNQPEPLHTSFASPFVSSMSAVPLEQDFALPACYNVANIQPLSSRIPGFSDETLFYIFYSMPRDIMQELVAEELMGRKWRYHKLERCWLTRDESYPGPVDVERGVSERGVYLLWDHTSWKKIRREFILRYEDLDNRLDASRTVTRAAAGQSLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUQ9</accession>
    <name>A0A9X0BUQ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial ribosomal protein MRP51</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789946.1">
        <property type="nucleotide sequence ID" value="XM_056934752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUQ9"/>
    <dbReference type="GeneID" id="81625001"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016712">
        <property type="entry name" value="Rbsml_bS1m-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11709">
        <property type="entry name" value="Mit_ribos_Mrp51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="52207" checksum="5569FA5BEC8418FE" modified="2023-11-08" version="1">MATARLSPTANLLRKSRLFALPKALQPPQDPPSSKAVFESETATLPHPIRASIVTPQRTLARGDWGLKRPLPAKSTSEKSSRPVVRLLALDTYEHVTDFESAADHTMTLEKFQELHMPMSLPAKVNYATSIVPRHQSPFETHVDNTETSTGLGEPGAKQYRHSGPWLAGMTQAEFAAYLAQITRKKPELVQKLRERLVAKRTAEARKQAQDNGQDLENLQVPQVTDEEFQTYIKTLRNDPFSLGPVVFDLLDLPSSPAVPSERIGRKYYQSPATKLSAAEYAVTGPPKTHPSAGLSYTRSHALTYNHPQYGPQAYQRPVEARILRPKGRFRGRMSRAIAGIGGIAVEDLNAMTFMDQGSPPGLTFFDATIPGGAKYWVTPIRAAVDSDGRIGLSSYRAGASSKAPYGIEDYKKPGPASITDAAHRHTNTVPRLDRPRYQQRPQAGRQPMKGTEDIARLLMNDLRAGAQKKDSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BV90</accession>
    <name>A0A9X0BV90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-arabinitol 2-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_005629</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790425.1">
        <property type="nucleotide sequence ID" value="XM_056935231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BV90"/>
    <dbReference type="GeneID" id="81625480"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF103">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5485641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="360" mass="39031" checksum="E9483371FA31D329" modified="2023-11-08" version="1">MSVARQFLRTCRAGRNTVPIVTRIPTNHFSTTRANCLQTTDQKNRIPEKEVPVTDYDAGHSSAHKRTLPVNPTPLRDTSSSSWPDPETVDPLTRDVYERMPKTMRNMSMFGKTVIITGGARGLGNHMARACAEAGAKNIVIFDANQELGDEAAAELHDKTGLPISFYRVDVRDAAAITASVQACVEKYGVPDVLINSAGIADSNIKAETYDVAMFRRLIDINLTGSFLMSQAVGRTMIAAGKPGSIILVASMSGTIVNYPQEQSCYNASKAGVIQLAKSLAAEWAKNEIRVNCISPGYMDTALNRVPALEAQKKIWKSLTPQNRLGNVDELNGLCVFLGSDASKFMTGANCIIDGGYTCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXJ7</accession>
    <name>A0A9X0BXJ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hikeshi-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_003751</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790894.1">
        <property type="nucleotide sequence ID" value="XM_056933353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXJ7"/>
    <dbReference type="GeneID" id="81623602"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="4">
        <location>
            <begin position="178"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5488861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="25754" checksum="765428D65A58E953" modified="2023-11-08" version="1">MFSVVIPGRPCLTDIVAVDGQPNGQATKFAFSIPVSASFKELVVFFLPGTVLPPNTGAAIYIQLPDPNTGSPTEFRFIGALANERPSGIFKIHPPSQLPNGQQRRSEAEEEDEMLDEGASNSGTGSGGVATLGISIEPAQNIAPQLSALEAERAGAGAGAGTGTGDQSPEQQRQKQISTKVLAQRIIGSAFNFLASFAESDPSRKGHEVVPLKSFRDWWSKFERRIEMDPGFLEREDPNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXN7</accession>
    <name>A0A9X0BXN7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790717.1">
        <property type="nucleotide sequence ID" value="XM_056933176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXN7"/>
    <dbReference type="GeneID" id="81623425"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="117" mass="13225" checksum="D1D3E7FB629398CD" modified="2023-11-08" version="1">MSETPPNSSKNRRRRHQRIQESFPPPNSDTLHPFGQPQFFENVRDVDMTDVVEENTDVEMIDAPPVSYEGAPTWVNDSFEQTKIIAEGLASINAALAQLEWYVRTGIVPVEPTSKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY83</accession>
    <name>A0A9X0BY83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791287.1">
        <property type="nucleotide sequence ID" value="XM_056933746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BY83"/>
    <dbReference type="GeneID" id="81623995"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="361" mass="39191" checksum="144A0814506FFB2B" modified="2023-11-08" version="1">MPEKTEHVKDAVLSAMSNSTSCVIEPNPDVSGTGIRASIYALCLGGTIVSYALRVFSPGEDEEEFSRGVSSALGMQGMALLCTAIYQTFRKELTLFHAICVVHLLALLGLDLASKGRYSGFGPWRLWVFVCVQVVSLAAFIAFNVYLWVTAPTFGSQPSCNPDTVYVVFGVSIRAVSPIFRYIILGTLGALAGGFILTFTCMLPCVCGAWVYKRRHPNSSISFQAQGTRGCGKWFIPGPSARSETRGPRPSRDRDAGSGQRMSGQALLNFTLNKAAYCGLCIYLIVSLEQTIQRNNLDPQERGWTFGQVIAIFLLLGVANELLNVLLANWDRKIGRALVVQSHDLPLARPASSAESNDSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYK3</accession>
    <name>A0A9X0BYK3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dihydroorotase</fullName>
            <ecNumber evidence="4">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_002348</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791910.1">
        <property type="nucleotide sequence ID" value="XM_056931951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYK3"/>
    <dbReference type="GeneID" id="81622200"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000041">
        <property type="entry name" value="Dihydroorotase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00219">
        <property type="entry name" value="PyrC_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004721">
        <property type="entry name" value="DHOdimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00856">
        <property type="entry name" value="pyrC_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137:SF1">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001237">
        <property type="entry name" value="DHOdimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="87"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5490781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="355" mass="39012" checksum="ED1DB24876FD661C" modified="2023-11-08" version="1">MPLSQLQGVKLPASADFHVHLREGPMMELVTPTIRQGGVNTVFVMPNLVPPITTVDHALDYKRRLQAIEPNVNYLMSLYLHESITPETIVEAKQRGITGVKSYPAGVTTNSSSGVVDYTSFYPVFAEMERQGLILNLHGEAPSRGDVTVLSAEERFLPILAELHAKFPKLRIILEHCTTAAAVEAVKKCGPTVAGTITAHHLSIIIDSWAGDPFCFCKPVAKTPADRDALLRAAASGNPKFFFGSDSAPHPSASKRGGEKIAAGVFTQPYTTQVVLDSFEQAVENGVLKDEDITPEIVEGFMSKFGRAFYDIGQEQKEFIKLEKKGEKIAEILKSEQTDVVPFRKTQETWTVTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYV2</accession>
    <name>A0A9X0BYV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Geranylgeranyl pyrophosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_002426</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791988.1">
        <property type="nucleotide sequence ID" value="XM_056932029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYV2"/>
    <dbReference type="GeneID" id="81622278"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5490859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="374" mass="41547" checksum="C52DEA701B0B68C3" modified="2023-11-08" version="1">MSSEFQATSAMPSQESSAEAANGSVSASLEETSPLDSDMPSKPQHRRNRSSVDGTKYKDGTWSAKNEKILMGPYDYMHGHPGKDVRRQLIQAFNSWLQVPSESLAVIDKVVRMLHTASLLIDDVEDSSVLRRGIPVAHNIFGTAQTINSANYVYFLALQEVQQLNNPAAIDIYVKELLNLHRGQGMDLFWRDTLSCPTEDEYLEMVGNKTGGLFRLAVKLMQAESSTGKDCVALVNVMGLIFQICDDYLNLANTTYTKNKGMCEDLTEGKFSFPIIHSIRSNPSNHQLLAILKQKTQDEEVKRYAVQYMHSTGSFEHTRRVVRDLHERALALIQVIDSTPKVNGAGDGHMVRAVLDKIVNTTLSPAEDEIIGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYZ1</accession>
    <name>A0A9X0BYZ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791780.1">
        <property type="nucleotide sequence ID" value="XM_056934239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYZ1"/>
    <dbReference type="GeneID" id="81624488"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="212" mass="23457" checksum="DB8262638A831878" modified="2023-11-08" version="1">MCTQNYTTYLACNHTYPSHKTLCPEARAGIPLQARTGCGARLHILRDKIRGAAETRKSTSKYVQGLGSAGTVNGDRDGDGNGNGNGSERERESGCQDHDQDQGGRWNMRGLNWWMGFRIPDERRVEREGLCADCSWMLKVEMGRVLRGWEMGDEKRDRRERGMDGGVDSRARDETDGGECEGGGRFPSTAEDGRSPDSKESSAGGMWARLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ51</accession>
    <name>A0A9X0BZ51_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_002977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792539.1">
        <property type="nucleotide sequence ID" value="XM_056932580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ51"/>
    <dbReference type="GeneID" id="81622829"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000025">
        <property type="entry name" value="40S ribosomal protein S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_eS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5491410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7683" checksum="268DCB322C2E08CD" modified="2023-11-08" version="1">MDSSKQPVKLVKVTRVLGRTGSRGGVTQVRVEFMDDTSRSIIRNVKGPVKVDDILCLLESEREARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZQ2</accession>
    <name>A0A9X0BZQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SIP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein sip5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_003100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May negatively regulate the SNF1 kinase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SIP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792662.1">
        <property type="nucleotide sequence ID" value="XM_056932703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZQ2"/>
    <dbReference type="GeneID" id="81622952"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24139">
        <property type="entry name" value="SIP5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039301">
        <property type="entry name" value="Sip5/DA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315:SF1">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="500"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="556"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="610"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="557"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="612"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="638"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="801"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5491533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="811" mass="86609" checksum="EB58485FD106E528" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZT0</accession>
    <name>A0A9X0BZT0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_001489</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793123.1">
        <property type="nucleotide sequence ID" value="XM_056931092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZT0"/>
    <dbReference type="GeneID" id="81621341"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF5">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="149"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="149"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5492743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="317" mass="34048" checksum="336D51D41B7DEF41" modified="2023-11-08" version="1">MNEFQVMHSYLPVPSNPGQSDPLDEASLAAVLLNSTVPETPAPPLIPSPSQPSRLSSRAPGPGDHSGTTVTSGGAPAYYSGHSQGCSQPSPPSSVHEMAPWASSTWASSSPRYPEDAVSSEVDISKASGTSPAATPATSELEYGRVVPYSQLIWEALMAAEDHMLPLQGIYEWFRQNTDKPNAESAKGWKNSIRHNLSMNAGFEALKVEGAGKRTLSYWRLTEEAVQHGVQSTTRYRKVGGKRGGNCGLPDTARQRPVSRGERRVPASPSAKARVMVRARTALVAAGPPRCSGFETQSKLTRAWCQAPLHDKFGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C038</accession>
    <name>A0A9X0C038_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase II degradation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_001908</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793542.1">
        <property type="nucleotide sequence ID" value="XM_056931511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C038"/>
    <dbReference type="GeneID" id="81621760"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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    <dbReference type="PANTHER" id="PTHR16308:SF13">
        <property type="entry name" value="PROTEIN LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308">
        <property type="entry name" value="UBIQUITIN ASSOCIATED PROTEIN 2-LIKE/LINGERER"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="57"/>
            <end position="100"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
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            <end position="371"/>
        </location>
    </feature>
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            <begin position="412"/>
            <end position="452"/>
        </location>
    </feature>
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            <begin position="537"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="684"/>
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        </location>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
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            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
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        </location>
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            <begin position="139"/>
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        </location>
    </feature>
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            <end position="190"/>
        </location>
    </feature>
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            <end position="254"/>
        </location>
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        </location>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="860" mass="89314" checksum="36A042FC9912A518" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0D4</accession>
    <name>A0A9X0C0D4_9EURO</name>
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            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="34"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="291" mass="33698" checksum="694B73DE66EA2D58" modified="2023-11-08" version="1">MGELLEKSCVACGWTHDKEKRCHYTSHIKLFYGASTRGVWSIGSDVILKDRPDEGPKAKVEVKTLNYLATHTDIPIPKVLRDWVDRDGRYFVLNERIGGQTLEEAWTSLSEPQKIDVADQVVKVRKRLRSVTSTSIQCVDQSPCYPGLLFFDLEARGPFHSDQELWDALALHLRHLPQQVLENLKKRLPKCEPYVLTHCDLNLGNIMVQDGKVVGILDWEYAAFFPIWYEYVSASFGFTDMDVEWKKLLRERLQVHGEAHENAKAFWTDMRNVRQYPNLDEKGQETFERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9X0C0D6_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">N7539_001731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Aspergillaceae</taxon>
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            <authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492985.1"/>
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    <dbReference type="GeneID" id="81621583"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="179" mass="19718" checksum="769291850A5E9B6E" modified="2023-11-08" version="1">MIKYTLVNKTGFYDQLLPQYGVQESWVEISEVETSERWCIPNLRLGGQACHNNNVKHLDYPHAKKDPDISNPKATTIRTLSKRWLPLFPGLPKTSRADGQRQGNWRATEKKEEKQKANLIITVISAVLMILPFAGEVAGSLGAAAWVANAILLADVASNIAIASYDIIQNPKIGAYGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0J0</accession>
    <name>A0A9X0C0J0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_001911</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793545.1">
        <property type="nucleotide sequence ID" value="XM_056931514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0J0"/>
    <dbReference type="GeneID" id="81621763"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000354">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
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    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF64">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="78"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5493165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="520" mass="57104" checksum="2F248C700ACDDDEC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0K5</accession>
    <name>A0A9X0C0K5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_001956</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793590.1">
        <property type="nucleotide sequence ID" value="XM_056931559.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81621808"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000003">
        <property type="entry name" value="Histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000044">
        <property type="entry name" value="Putative sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000285">
        <property type="entry name" value="Putative sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000579">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
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    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF46">
        <property type="entry name" value="HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="62"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="16">
        <location>
            <begin position="1928"/>
            <end position="2151"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="17">
        <location>
            <begin position="2191"/>
            <end position="2314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="484"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2321"/>
            <end position="2366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="525"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="2342"/>
            <end position="2359"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="13">
        <location>
            <position position="2245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5493210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="2366" mass="263096" checksum="6C2D1B6B04A185A8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2N5</accession>
    <name>A0A9X0C2N5_9EURO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">N7539_000903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
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            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794800.1">
        <property type="nucleotide sequence ID" value="XM_056930507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2N5"/>
    <dbReference type="GeneID" id="81620756"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5495787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="84" mass="9185" checksum="57F31F5C47BBC782" modified="2023-11-08" version="1">MFQGLATSTPTRLDLEFRRSNHSRQAEFEFRAKAGTSITWHLRSNRQSVATPTSQPLMGSCSLIGAELTLVLGHSHPDPGTHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2Q6</accession>
    <name>A0A9X0C2Q6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_000425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794322.1">
        <property type="nucleotide sequence ID" value="XM_056930029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2Q6"/>
    <dbReference type="GeneID" id="81620278"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ-like_C11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052243">
        <property type="entry name" value="Mito_inner_membrane_organizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11875">
        <property type="entry name" value="DnaJ-like_C11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="118"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5495309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="850" mass="95428" checksum="11C0638FD8926C68" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2Q9</accession>
    <name>A0A9X0C2Q9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794744.1">
        <property type="nucleotide sequence ID" value="XM_056930451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2Q9"/>
    <dbReference type="GeneID" id="81620700"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF179">
        <property type="entry name" value="TRNA(ADENINE(34)) DEAMINASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="154" mass="17020" checksum="BEEC95B67A2BBD93" modified="2023-11-08" version="1">MPTAPELAYLERCIELAHESLQAGDHPFGSILVNSTGQILKEERNRVCTANDITYHPERVLAVWAQQNMTPEDRAAATVYTSHEHCPMCSAAHAFAGIGRIVFASSSKQLDGWRTELGLPGSPVTALPIELVARGWRWRGRWMSWRGGFSSCIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKD3</accession>
    <name>A0A9W9WKD3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efficient mitochondria targeting-associated protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_009393</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM97/sigma-2 receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785710.1">
        <property type="nucleotide sequence ID" value="XM_056938988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKD3"/>
    <dbReference type="GeneID" id="81629238"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016964">
        <property type="entry name" value="Sigma2_recept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031032">
        <property type="entry name" value="TMP_97_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="9">
        <location>
            <begin position="11"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5466664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="182" mass="21253" checksum="2E53CACD2A3344B1" modified="2023-11-08" version="1">MSRMALPSRKRDLAYLFFFASHIPIIFLVDTVPLQPAWFRSNLSATIREYYIATYRDKFFEEPAPVWFNAFIWMELLYHVPASVWAVWGLMRDQRANHLDLFGPSVLTDHPLIPVHLLVFGVQAFVTSLTCLVDVWSWTDRSMEEKQQITYLYGPYVALGALMALDMVLRLRAQLMPKVKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKI0</accession>
    <name>A0A9W9WKI0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Brix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_009447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785764.1">
        <property type="nucleotide sequence ID" value="XM_056939042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKI0"/>
    <dbReference type="GeneID" id="81629292"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000005">
        <property type="entry name" value="Similar to RNA processing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="206"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5466718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="435" mass="49742" checksum="0C163BB185BD8B7A" modified="2023-11-08" version="1">MGMKGQGRPPPNSGMEVKTANKLRRKMLHIKRKRTKDAERRAERYAFKKEESKNPKLREERLRRNVPLTLERKRVWDDAGSDAEEDGLGLSVDIERIKRAKQEEEEELNRPLKDGEDNSDDADSDNESVDSMIATSDEDEDDEDDEKEDAEDDDNQAGRGRKKSCLPTATERATSPTQSTRSTNLSLAPEALAAKFPSLFSNETPPAPKILITTAINSTLHNEAEILTDLFPNSVYIRRTAHRYSHKFSIREISKFAANRNFTTVVVLQEDQKKPSGLIVVHLPVGPTFHFSISNWVEGKRLPGHGRATGHWPELILNNFRTPLGLLTARMFQQCFPPLPDFEGRQVVTLHNQRDYIFVRRHRYVFREKRETEKAVVGADGKEMQGAEGIRTGLQELGPRFTLKLRRVDKGIQRTSGQEWEWKGGMEKERTKFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKZ5</accession>
    <name>A0A9W9WKZ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rhamnogalacturonate lyase</fullName>
            <ecNumber evidence="11">4.2.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_008979</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Endotype eliminative cleavage of L-alpha-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronic acid bonds of rhamnogalacturonan I domains in ramified hairy regions of pectin leaving L-rhamnopyranose at the reducing end and 4-deoxy-4,5-unsaturated D-galactopyranosyluronic acid at the non-reducing end.</text>
            <dbReference type="EC" id="4.2.2.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the polysaccharide lyase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.23" evidence="11"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785951.1">
        <property type="nucleotide sequence ID" value="XM_056938574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKZ5"/>
    <dbReference type="GeneID" id="81628824"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102210">
        <property type="term" value="F:rhamnogalacturonan endolyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10317">
        <property type="entry name" value="RGL4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10320">
        <property type="entry name" value="RGL4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000102">
        <property type="entry name" value="Rhamnogalacturonate lyase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1120:FF:000017">
        <property type="entry name" value="Rhamnogalacturonate lyase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000020">
        <property type="entry name" value="Rhamnogalacturonate lyase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029411">
        <property type="entry name" value="RG-lyase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016590">
        <property type="entry name" value="Rhamnogalacturonase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015364">
        <property type="entry name" value="RhgB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574:SF1">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14683">
        <property type="entry name" value="CBM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09284">
        <property type="entry name" value="RhgB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011794">
        <property type="entry name" value="Rhamnogalacturonase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041032835" description="Rhamnogalacturonate lyase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase B N-terminal" evidence="13">
        <location>
            <begin position="22"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="15">
        <location>
            <begin position="276"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="14">
        <location>
            <begin position="361"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="50"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR011794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR011794-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5469361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="528" mass="56878" checksum="795598E9DAE325F8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL04</accession>
    <name>A0A9W9WL04_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="4 15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_008994</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the NSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4 15"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785966.1">
        <property type="nucleotide sequence ID" value="XM_056938589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL04"/>
    <dbReference type="GeneID" id="81628839"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16493">
        <property type="entry name" value="RING-CH-C4HC3_NSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014857">
        <property type="entry name" value="Nse1_RING_C4HC3-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08746">
        <property type="entry name" value="zf-RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Non-structural maintenance of chromosomes element 1 RING C4HC3-type" evidence="17">
        <location>
            <begin position="233"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5469376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="328" mass="36910" checksum="13FCD7C2C7F04E81" modified="2023-11-08" version="1">MDIYDDRHRAFLQAFMARSTMTFEESQPVLAAIISAHESRDIAPEDVTQSTLNDFVDTVNGAISTFDLEIRTSRRQDPKDSADDSTTPPILIYALVNTTSDALTQLATTYSADEIAFVKRVLDYMFEENNTRRSEGMIISSMQAMRLSKAGSDRRRSTNVATQQTESGNAQNLTMQQAQEVMKSLTQEGWLEQSRKGNYSLSPRALMELRTWLVSEYNYEDMNGQMQNRIKFCAACKDIITVGQRCDDRNCPGRLHDHCVRNFFRMQQAETCPVCQKGWSGNNYVGERAVVEAARPRHSRLSQAQTVVASPTPTSEAGDPKLSDEEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL45</accession>
    <name>A0A9W9WL45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sister chromatid cohesion acetyltransferase Eco1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_009122</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. ECO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786094.1">
        <property type="nucleotide sequence ID" value="XM_056938717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL45"/>
    <dbReference type="GeneID" id="81628967"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO zinc-finger" evidence="11">
        <location>
            <begin position="145"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase ESCO acetyl-transferase" evidence="12">
        <location>
            <begin position="318"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="37"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="96"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5469504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="43819" checksum="3F8CC0FE180C46D7" modified="2023-11-08" version="1">MPWTVTNSFKRGLMKTYGRPTWRVYDDERYAIRESSAAVLSSPSRRNSIIGSEGTLDDIDDLTTPPSSPPPRLTPPPANTRKPTFAFLKRKLKENTGGSPLTEVNSNSVRSTADPPKQQQRQNSTHQPSLPTSQKTTPKPPALRQMQIDLGAEVRKTCATCGMEYIPSNSEDAALHKKFHEMNSTGVDLGKAFMRANASRWVYEATRFDEGYVVIVDRKATPSAKNQAKKVLEVVNKELSSPDIEDEVLWSQAEPPKHLHNESSEEKVDRYRVFLHMKDSRCVGLCLTERIWEARPVVRNDSERGTDGSSVSVKDELHPAIVGVSRIWTSGASRRKGIALDLLDCVVSNFIYGMEIPKDNIAFSQPTESGKRLAQRFFEESATWHVYNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLA5</accession>
    <name>A0A9W9WLA5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_009227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786199.1">
        <property type="nucleotide sequence ID" value="XM_056938822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLA5"/>
    <dbReference type="GeneID" id="81629072"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040912918" evidence="2">
        <location>
            <begin position="22"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5469609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="208" mass="23567" checksum="A7948D372BC8D8F0" modified="2023-11-08" version="1">MHLSLDRILLLLWLTFGSVNALGLSCIKVASALIGRPTHLYNLFQTEICERGCEPTVPHWDLWTRNNSFVPAVRNIMTRMNIPHSENALFKMGDDVAAIIKVQCGPMLGDRHICSDPATLADFGNCFKRYFFKASLKYIPILLPMASDAACKEQYQYLQGNELWDETIPKNMRAYASVCHDLEAESVERQQEPSGEEGSVEFENHEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQL6</accession>
    <name>A0A9W9WQL6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786432.1">
        <property type="nucleotide sequence ID" value="XM_056938424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQL6"/>
    <dbReference type="GeneID" id="81628674"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047655">
        <property type="entry name" value="Transpos_IS630-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033545">
        <property type="entry name" value="transpos_IS630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="58"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="241" mass="27935" checksum="63D7B7614354C6DE" modified="2023-11-08" version="1">MAIFLWDEFQMLATTSSIRRALISTGWSRKNSQRKAKEQNVELRETYLHNLSDFESYQLVYVDESGCDKRIGFRRTGWSPLGVAPKQVAQFHRDERYQILPAYSQDGIVLSRVFRGSTDASVFEDFIEELLHHCGRWPEPKSVLVMDNASFHHSERISQMCADAGVKLVYLPPYSPDLNPIEEFFAELKGFIKRNWSYYAEDPTQGFSIYLEWCINQVGAREESARGHFRHSGLSIEDLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQR5</accession>
    <name>A0A9W9WQR5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786503.1">
        <property type="nucleotide sequence ID" value="XM_056938121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQR5"/>
    <dbReference type="GeneID" id="81628371"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="437" mass="50081" checksum="8A39C10A1577768E" modified="2023-11-08" version="1">MTGSLYCNDIVSPPDELELWEPNWQYAPTPGYLRSPYSTRSTCSPDRSSIPENGSEPASQSQTDTLKLLQLSEWEEGRDYDEDPPTCIHYLIEWRVTVNNKIVAKDTEEDVVLAPNAFWEETLKGKLENVLRGKVSADRRVRADDTAIVVSVNDRSQRDLTKRFDKLDINWTAIEKKLHMWSGLFYHGKKLRLNICFNYVEDRSSPTAGRRGEKRGKSSVTTRMLDDRDAQLDAEENSCGQQSIWRRVYNLMKCASASCHLGPYCWLDPMGKKHYQLRTHHLRRLVTYVEKGGVLETHRDVPDDIREELYMEEQQRLEKKSSHPSGKDITAPKVALETASLKDIGPLHIPGFRDVAVKEYGEWLASSVEDDNLKAAFRQACDVTLSDGFDLEHIYKDQNPEFFVGKGIKPGIARTFVENIRDWVENVKKTAHVVEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WR24</accession>
    <name>A0A9W9WR24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786565.1">
        <property type="nucleotide sequence ID" value="XM_056938183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WR24"/>
    <dbReference type="GeneID" id="81628433"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5472019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="82" mass="9151" checksum="425F4BA4CD3C1EA9" modified="2023-11-08" version="1">MPPRTGYSSLAGFEIDENGRGSWNGYQEQEQDRGKTIRASTVCVQSEVSQMSEIGEPYEITGMTERAARTVESTQVFRMVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WR33</accession>
    <name>A0A9W9WR33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_008525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <dbReference type="EMBL" id="KAJ5471956.1"/>
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    </evidence>
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            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="1244" mass="137557" checksum="37130F321B341A41" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35226" checksum="0237E83CA3EC014B" modified="2023-11-08" version="1">MASDLEQLIEMGFEKERAELAVKKTGNLQGALEWLEVNQDKSLEEIKASQAEEADNEEGPALQPGEEARSLVCNECGKKFRSQAQAEFHASKTEHTDFSESTEELAPLTEEQKKERLQELREKLAAKRAAQAEQDKIEQRKNEEIRRKNTQENQDAKEALERKQRQKEEAKKRQEKMDDKAHLARVKAQIQADKEERRRKAERERAERAGTAIPQAAAEPVPAPTTTGPVVSKPASAYTETRLRFQTSQGNIMKTLPVTLTLFEVAEALRQEDGVNVQSFTQTFPKKIFDKELFGESLKDLGLVPSASLIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTH3</accession>
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        </submittedName>
    </protein>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
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                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="81628105"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5475189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="104" mass="11642" checksum="C01340F485E49BD9" modified="2023-11-08" version="1">MIIGIITVHATRNEIAPTGLFGLLSDAPIQLIDLFDAKLVDRYLQLFENLRYSQGRMTCQFLRNLEDLTTNAGIGTREAQNRMLHLANKTLHGPGSWASHTFMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTJ5</accession>
    <name>A0A9W9WTJ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Protein phosphatase PP2A regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_008311</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787003.1">
        <property type="nucleotide sequence ID" value="XM_056937911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTJ5"/>
    <dbReference type="GeneID" id="81628161"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000174">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000189">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="403"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5475245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="470" mass="53084" checksum="9D09A02A703E7991" modified="2023-11-08" version="1">MVDRDSGTPTWKFTQCFGDKGDVEDITEADIISTVEFDHTGNYLATGDKGGRVVLFERNETKKTCEYKFHTEFQSHEPEFDYLKSLEIEEKINKIKWCRRQNASHFLLSTNDKTIKLWKVFDKSLKVVAENNLSNELTPAGAAGGGGIPRAPRGTFKSAGSLKMPRLTHHDTVVAAVPRRTYANAHAYHINSISVNSDGETFISSDDLRVNLWNLNIQDQSFNIVDIKPANMEELTEVITAAEFHPVSCNWFMYASSKGTIKLADMRQRALCDEHAKLFEQEEDASSRSFFSEIISSISDVRFSHDGRYIVSRDYLTVKIWDVNMERQPVKTIPIHEHLRPRLCDTYENDSIFDKFEVVFSGDAENVMTGSYNNNFMIYPTEEQKETEIVLQADKSAFKAKKVGVPTPMNKNGKKAGSRSGSPAGPGSRMKKETDADQIDFNKKILHMSWHPFEDSIAIAATNNVSFVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTQ2</accession>
    <name>A0A9W9WTQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787087.1">
        <property type="nucleotide sequence ID" value="XM_056937995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTQ2"/>
    <dbReference type="GeneID" id="81628245"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="135"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5475329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="205" mass="23324" checksum="69A7CCF0CC0F7306" modified="2023-11-08" version="1">MRDLRDDSDPLPHYGVIASDNKVIKHGETREQLPLRTSALCFEIEAAGLMLDFPCIIIRGICDYADSHKNKAWQGYAALVAAAYTKELLEYIPVRQVSQEGLAVDMCKHHREKLAFVRTEKHNRCHQTFKTSPYEDIEYTCWLESSANDLLWVTADPGCGKSVLSRSLVEDFLKDSTSDVTVCYFFFKDSDKPDRLNKALCSVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTT5</accession>
    <name>A0A9W9WTT5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_007688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787154.1">
        <property type="nucleotide sequence ID" value="XM_056937289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTT5"/>
    <dbReference type="GeneID" id="81627538"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5475401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="221" mass="24288" checksum="AD5CDFA6E2EA8B3D" modified="2023-11-08" version="1">MQYSENLRGRAISSRRDQLYDILSGSNAAAQKEVRGGRSGKVILWVRENLGFEDGRDEDIARYISVGLKQIVLEDLLQERLDVEDQTEANPSGVGVLTTLAIKSFKKLSLLEIPQFLDHIIAAEVDSPALGSKGTKIGFLYWISGLSRKIAEFLALYDESIAIENQASQNATRVARESWRQTPILTSPQDAPADYGTPQSRLRASNTYAALSSSAAQTESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTY2</accession>
    <name>A0A9W9WTY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_007763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787229.1">
        <property type="nucleotide sequence ID" value="XM_056937364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTY2"/>
    <dbReference type="GeneID" id="81627613"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024146">
        <property type="entry name" value="Claspin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396:SF10">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5475476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="460" mass="50133" checksum="B4F0765E3AA25023" modified="2023-11-08" version="1">MSTQSTPRSARSPSYQGNSPRILTPGQKIKAMMAQFDSDSESDSETTKKTRLSLSKLDFGAKTTSAGHSNLHHSEDDSDEDNMMVRPKGRMAARMQGDTDVSAVSNKAQQASIPPQQPEPIRKNTEPKRNTNPRSPSPMSESSSDELPSAIPRRRPNARTTQSPVSQRHSSVSPAPARSSSPLFVSSAASQNGDISENRESETLANPKSNARFLALVAKKRKEREERERLEEERREARRAQMEHFSSEIVSGEETEGEDGNSGQKLSQVPRQPRKASKKALEEMRQETQRMSRNMQLAHQAQTKKKLTKESLFAKFNFMQPPPAPTAAATTNSSSTAGSQQSSDGEIPKRHDRTPGTSPVLGPSDTEKPVPALTEISVPQVADAGAKPSEATLLAQPNNSKSPVGVDSAKASVMSRKEIRKPAQPAVRVLLSRQDVARQQKDDSDDDDLEVVTSPSRLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU17</accession>
    <name>A0A9W9WU17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L35Ae</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_007819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787285.1">
        <property type="nucleotide sequence ID" value="XM_056937420.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81627669"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018266">
        <property type="entry name" value="Ribosomal_eL33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01105">
        <property type="entry name" value="RIBOSOMAL_L35AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5475532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="141" mass="15989" checksum="C39ABB950735C83C" modified="2023-11-08" version="1">MPSEQGHRLYVKGRHLSYQRGKHNLNPNTSLVQIEGVTDPKAASFYLGKKVAFVYRAKREVRGSNIRVIWGKVTRPHGNSGVVRAKFRHNLPPQVLRCHRPRHALPLHHLNSFSMLYLVGEFPRSFLHADGFSVSGKNGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU69</accession>
    <name>A0A9W9WU69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787101.1">
        <property type="nucleotide sequence ID" value="XM_056938009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WU69"/>
    <dbReference type="GeneID" id="81628259"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF3">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="813" mass="92784" checksum="C1AF0389D8FCC7F4" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUX3</accession>
    <name>A0A9W9WUX3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cellular nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5476957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787501.1">
        <property type="nucleotide sequence ID" value="XM_056936702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUX3"/>
    <dbReference type="GeneID" id="81626951"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000023">
        <property type="entry name" value="Cellular nucleic acid-binding protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
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        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5476957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="174" mass="18479" checksum="C8589FA2F124BE6A" modified="2023-11-08" version="1">MDSRSRACYNCGDASHQAKDCPKKGTPTCYNCGGEGHVNRECPEPPKERTCYRCGQTGHLSRECPQGGNSYGGASGGSQECYKCGQVGHIARNCSQGGGNYGGNGGYNSYGSRPQTCYSCGGFGHMARDCTQGQKCYNCGEVGHVSRDCSTEARGERVCYKCKQPGHVQAACPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVB8</accession>
    <name>A0A9W9WVB8_9EURO</name>
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        </recommendedName>
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        <name type="scientific">Penicillium diatomitis</name>
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477327.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
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        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF13">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE OMEGA-1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13410">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="28"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="117"/>
            <end position="261"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5477327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32827" checksum="1798EEB96B36C381" modified="2023-11-08" version="1">MPAHPDSDLHPEATGRAKTLVDSHRGQQTLKLYAGWFCPFVQRVWLALEEKQIPYQYIEVNPYNKPRSLLTLNPRGLVPTLQCPTESGPRPLYESTVILEYLEEAYADHTPQFLPKDAYERARARIWMDYVTSRIIPAFHRFLQYQSTEEDDDSGAGKHAGLQQMRQEFLNHLKTWTTQMHSEGPFFLGSEISLPDLVLAPWAVRLWVFDEFKSGGTGLPEEEQGGEDEKVWARWRKWLSAIESRESIQNTTSETKHYMPIYKRYADNTAQSELAKATRAGRGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVH4</accession>
    <name>A0A9W9WVH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_007561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056937162.1"/>
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    <dbReference type="GeneID" id="81627411"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:prefoldin complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Prefoldin subunit 2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
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        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5477417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="15068" checksum="9F97F71EE8851AD5" modified="2023-11-08" version="1">MSSQQQIDPKKQQELQLQYTNFKNTLQQLASKIGDIEQEAEEHKLVIETLNPLPSDRKCFRMVNGVLVERTVQDVLPALKTNSDGLKQVLDDMLKQYKNKQNELDNWKNNVLTAAFFIEQKKNNIQVVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1X2</accession>
    <name>A0A9W9X1X2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sequence orphan</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
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            <taxon>Eurotiomycetes</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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            <authorList>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788299.1">
        <property type="nucleotide sequence ID" value="XM_056936364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1X2"/>
    <dbReference type="GeneID" id="81626613"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038781">
        <property type="entry name" value="C365.16-ike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845:SF1">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5480869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="35912" checksum="76646B3C9208D9A2" modified="2023-11-08" version="1">MSMTRSAVAQDTSSPIIPGSEHLPKLSGASTQALQSPVPLSTWNTSNLGMRLGIDVVSAASAGALTCPLITIIDRAIIEKASKGFPIRETITKCLKSMVTKPAGFFLGTPFLLIYTLYTSTYLTANAIDTVSSTLRNQSYSTVTAGPTKFLSTTAVNMAICVYKDARFAKIFGASPPPSTTPSQKSGSTTTPRPAVCHPMPSASPAAPTIPKVSYSLFCLRDSVTIFASFNVPTLIAPSIPDFIAATPSMKAATAQFACPALMQFFSTPMHLLGLDLYNRQPLGGLPWTDRLGRIRRDYISSSFARMGKIVPAYGIGGVVNVRMRATLMERLEQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X330</accession>
    <name>A0A9W9X330_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788913.1">
        <property type="nucleotide sequence ID" value="XM_056935989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X330"/>
    <dbReference type="GeneID" id="81626238"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="7"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5482941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="130" mass="14429" checksum="2E72F53D477FE1ED" modified="2023-11-08" version="1">MSSAACIFCKIIKGDIPSFKLFESDKVFAFLDIQPLSRGHALVIPKYHGAKLTDIPDNDLLEILPVAKKIALASGASDFNILQNNGRIAHQVVDHIPKPNEQEGLGIEWPAKETEMDKLKALYEEIKSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X4X5</accession>
    <name>A0A9W9X4X5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000007">
        <property type="protein sequence ID" value="KAJ5483831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789101.1">
        <property type="nucleotide sequence ID" value="XM_056935633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X4X5"/>
    <dbReference type="GeneID" id="81625882"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5483831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="84" mass="9030" checksum="572321FFF3A003E6" modified="2023-11-08" version="1">MKKKAERGSVTQLAVSEPDYYNLTYFTNNMHDTVSERPKTASKAAVSGLSLTVGVLGVTCAKAHGRPRLLPPVLRVGVPGAWPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X592</accession>
    <name>A0A9W9X592_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G protein-coupled receptor GPR1/2/3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_005963</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789437.1">
        <property type="nucleotide sequence ID" value="XM_056935565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X592"/>
    <dbReference type="GeneID" id="81625814"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022596">
        <property type="entry name" value="GPR1/2/3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF41">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11970">
        <property type="entry name" value="GPR_Gpa2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040905453" description="G protein-coupled receptor GPR1/2/3 C-terminal domain-containing protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="G protein-coupled receptor GPR1/2/3 C-terminal" evidence="7">
        <location>
            <begin position="247"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5484167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="431" mass="49246" checksum="D5A8B73CFE2ABA8B" modified="2023-11-08" version="1">MVVLMHLLGALYLDGAGQPSVTRRWEFTEETPLTGLERSLFIMMGVVALLSLVSTIGLLTFLTHRFIFWQQYYKHPLAHNQYVVLIYNLLLVDLQQAIAFVICLYWVGQGRVHFGEIACYLQGWWIQTADPGSGLFVLSIALHTSAVVLRGRQLPFKVFICFLIGLWAFILILGVIPVSIHGSQSFVITEANWCWLSPANEHGRFWGHYFWIFSAEFGTVFLYTILFIRLRRRMAQAKTLRIGQQESLHRLNRVVIYMVIYPFIYLVLSLPLAAGRMATARGHPPGKTYFAVAGSFMALSGVVDVAVYALTRRHLLLDTEHHTTDRIYDNTISEWHTQITTTAVPEDRPRKQSRLVSKISSKLRRSENHEVEQEEVSRKNLFDDSTDDIVPKSDVELSTFTVVYQETTIEISHEPATPTDLTSRGLRRIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5J6</accession>
    <name>A0A9W9X5J6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_005831</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789305.1">
        <property type="nucleotide sequence ID" value="XM_056935433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5J6"/>
    <dbReference type="GeneID" id="81625682"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5484035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="123" mass="13819" checksum="F1C2C13A1A14E2A0" modified="2023-11-08" version="1">MASNATYKDRQLLAVIGDEDSVTGLLLAGIGHVTEGADAQRNFLVVDSKTETSQIEQAFRNFTEERKDIAILLINQHIAERIRHSVDTFADPFPAVLEIPSKDHPYDPEKDSVLKRVRRLFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5T9</accession>
    <name>A0A9W9X5T9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_004702</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789498.1">
        <property type="nucleotide sequence ID" value="XM_056934304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5T9"/>
    <dbReference type="GeneID" id="81624553"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF2">
        <property type="entry name" value="SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="21"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5484714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="381" mass="42174" checksum="56332780A319CF4C" modified="2023-11-08" version="1">MGDFVTEAFTLLAVAIVIIALRTAARWIMVGPRNFQADDYLMILACIVYGLETGAAYMVGAWFQGLANNAMTDEQRRTLSPDSEEYRLRVGGSKVQVTGWSLYTLLLWLLKTCMAIFYSRLTSGLVNMRVRIIVAYVLIGVTYLVTICSILFGCHPMHKNWQIYPNPGNSCQPAVSKIDIYVTVVLNVTTDIYLISIPAPMLFKARLHWREKLELLILFSGGIFVMMAGILRCVLILTAGANGAQQAGSWACRETFVAVVIGNVPMIYPLFRRVARRAGLYLSSRGGGSAESYPAYQLSEGGESGYGKRKKFRHPLSIPGDTQWNTVSDEQMMLPTSRQQPPTCTAGSEGDWDTHSHHSSSGGIKVVHETIIQSTKKDSHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5W9</accession>
    <name>A0A9W9X5W9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2-methylcitrate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_004885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789681.1">
        <property type="nucleotide sequence ID" value="XM_056934487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5W9"/>
    <dbReference type="GeneID" id="81624736"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4100.10:FF:000001">
        <property type="entry name" value="2-methylcitrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.120:FF:000001">
        <property type="entry name" value="2-methylcitrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012705">
        <property type="entry name" value="2Me_IsoCit_deHydtase_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006943">
        <property type="entry name" value="PRK09425.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02330">
        <property type="entry name" value="prpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF16">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="5">
        <location>
            <begin position="76"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="6">
        <location>
            <begin position="350"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5484897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="556" mass="61814" checksum="77257A5D737290B3" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6L0</accession>
    <name>A0A9W9X6L0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RED-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_005215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790011.1">
        <property type="nucleotide sequence ID" value="XM_056934817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6L0"/>
    <dbReference type="GeneID" id="81625066"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039896">
        <property type="entry name" value="Red-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012916">
        <property type="entry name" value="RED_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12765">
        <property type="entry name" value="RED PROTEIN IK FACTOR CYTOKINE IK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07808">
        <property type="entry name" value="RED_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RED-like N-terminal" evidence="4">
        <location>
            <begin position="81"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="463"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5485227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="527" mass="58033" checksum="CC129A0109294B72" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6U0</accession>
    <name>A0A9W9X6U0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_005408</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TBCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790204.1">
        <property type="nucleotide sequence ID" value="XM_056935010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6U0"/>
    <dbReference type="GeneID" id="81625259"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5485420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="117" mass="13319" checksum="B1E89F2977DB7E08" modified="2023-11-08" version="1">MPPRSQLEINTSSVLRLVKEEASYHQEAVQQTERIKKLENEQSEDENREFLLQQERRALDETKKVFPSLKKKLHDIVTELESLIAEEAAKGSDSNVDQITAAKEAIAQAKTAEREVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X703</accession>
    <name>A0A9W9X703_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790313.1">
        <property type="nucleotide sequence ID" value="XM_056935119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X703"/>
    <dbReference type="GeneID" id="81625368"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF3">
        <property type="entry name" value="CUPIN 2 CONSERVED BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="89"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="195" mass="21181" checksum="CAE6A66651AD895B" modified="2023-11-08" version="1">MVEIKHPKTIRPLSRFITTHNDDGKAIFSNILPETLPVQQIPDGAQFSLAYTTQRFPAKLDNDADITEYSSHLSSPPGLSISSGTVCRIVDIQPGATSPMHRTVSLDYGVVLEGEIELVLDSGETRLLKRGDVAIQRGTNHAWRNVTPDAVDPETGKSIPQWGRMLYVLSPTVPLEVGGQKLGEEIHGMGVPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X727</accession>
    <name>A0A9W9X727_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-ornithine N(5)-oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_005543</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790339.1">
        <property type="nucleotide sequence ID" value="XM_056935145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X727"/>
    <dbReference type="GeneID" id="81625394"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5485555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="765" mass="84765" checksum="0325EB9A327C1383" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X757</accession>
    <name>A0A9W9X757_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xaa-Pro dipeptidyl-peptidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789699.1">
        <property type="nucleotide sequence ID" value="XM_056934505.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81624754"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="alpha/beta hydrolase"/>
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    </dbReference>
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        <property type="entry name" value="Galactose-binding domain-like"/>
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        <property type="entry name" value="AB_hydrolase_fold"/>
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        <property type="entry name" value="CocE/Ser_esterase"/>
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    </dbReference>
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        <property type="entry name" value="Peptidase_S15"/>
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    </dbReference>
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        <property type="entry name" value="PepX_C"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="323"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5484915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="560" mass="62150" checksum="7ACCF68BBB47234D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7F4</accession>
    <name>A0A9W9X7F4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790300.1">
        <property type="nucleotide sequence ID" value="XM_056935106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X7F4"/>
    <dbReference type="GeneID" id="81625355"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32175" checksum="C5FA2D2DB4915625" modified="2023-11-08" version="1">MAAEHQSGPRQDHKKPIQDPHTQDDASDSDEDEFHDARFPAEEEARLLKESQEIKKEANSLFTAACYDQAISTYDRALSSCPNYLDYDIAVLRSNIAACYLKTEEWKAAIDSATASLDRLEKIIPMTDGKNKTGEGKRASDPAATSTENTDVVELSASDAEAEEKQLAQLKDLDTQRTNVLRIRAKSLMRRAKAKSNLGGWGNLQGALEDYQVLSSMETLPSDEKRIVQKALRELPPRVNEAKDKEVGEMMSKMKELGNGFLKPFGLSTDNFKFVQDPNTGGYSMNFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7I1</accession>
    <name>A0A9W9X7I1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Solute carrier family 40 member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_005098</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in iron transport and iron homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789894.1">
        <property type="nucleotide sequence ID" value="XM_056934700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X7I1"/>
    <dbReference type="GeneID" id="81624949"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17480">
        <property type="entry name" value="MFS_SLC40A1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ferroportin-1"/>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
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    </dbReference>
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        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06963">
        <property type="entry name" value="FPN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="81"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="137"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="163"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="376"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="388"/>
            <end position="408"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5485110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="538" mass="59252" checksum="6412142F3D83CBA6" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X864</accession>
    <name>A0A9W9X864_9EURO</name>
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        <recommendedName>
            <fullName evidence="2 4">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_005443</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056935045.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81625294"/>
    <dbReference type="Proteomes" id="UP001148312">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Polyadenylation factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Pfs2-like"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="match status" value="7"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
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        <location>
            <begin position="179"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="221"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="263"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="376"/>
            <end position="408"/>
        </location>
    </feature>
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        <location>
            <begin position="444"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="565"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="568"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5485455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="599" mass="66208" checksum="0A53E6E322FBE991" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XBQ3</accession>
    <name>A0A9W9XBQ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_003355</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790498.1">
        <property type="nucleotide sequence ID" value="XM_056932957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XBQ3"/>
    <dbReference type="GeneID" id="81623206"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="89"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5488465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="559" mass="60308" checksum="D45A1DFD38B5D38C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XC71</accession>
    <name>A0A9W9XC71_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_003565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790708.1">
        <property type="nucleotide sequence ID" value="XM_056933167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XC71"/>
    <dbReference type="GeneID" id="81623416"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF18">
        <property type="entry name" value="SORTING PROTEIN SNF7 FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16692)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="273"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5488675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="484" mass="53857" checksum="70353B98F58C31E3" modified="2023-11-08" version="1">MSELLNYILNNEDAFRRNRLPSLYSDFTLQKRTNPDGYAVNIAAWEQALTKAAKRGYTFSRGVRPRSGSIENPKESKAGRKKTDHLIIRTDESLLRDLELAEWGRPVALGAVFDEAMRKRSMIPLALYKASETSLQKAQWRLIDPAALSPWNVVSWGVRQLKGIVIGPDGESAPNLQVQELVLVENLQEAAELIVKKATTNSISQLDQIYSKQSFIEEFASVLHDATELSDSDFDVLLLYLSRDSNAIAYDGKTIKFKPKDKTAEITPEDKSIASIKTLISTLSKQVKSLEDKIADLTASAKTALSNKNRISALSAVKSRKMVEHNLQQRLNTLAQLEEVYSKIEQAAGQVEIVQVMEASTGVLRSLHAQIGGAERVEDVMDELREEMSKVDEVGSIINEAGPVFDESEIDEELAAMEKSDHEEKEKKEAEATQRNLAELDSIKQASDETAGQTQRAKDVDSQLAHSIDKLSNMTMEERPLPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XD44</accession>
    <name>A0A9W9XD44_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylinositol transfer protein PDR16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_003969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791112.1">
        <property type="nucleotide sequence ID" value="XM_056933571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XD44"/>
    <dbReference type="GeneID" id="81623820"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000013">
        <property type="entry name" value="Phosphatidylinositol transfer protein PDR16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="127"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="339" mass="38606" checksum="CE8DF409DC967C92" modified="2023-11-08" version="1">MAAKDSLAGEKTAASPVATAPGVVQKPLIHPADDAKPQPPPALTPDQQAKYETVLKTVSSWTTVPIKAEKNAPTEPITDDERMWLTRECILRYLRATKWNSFEAETRLQKTLTWRREYGLDKLTPDYISIENETGKQVIMGYDVHARPCLYLLPSNQNTERSDRQIQHLVFMLERVIDLMGPDQETLALLVNFKETKSGENASVGQAKQTLDILQNHYPERLGRALVINVPFLIWGFFKLITPFIDPNTREKLKFNEDLRTHVPPSQLMKPVGGELEFQYDHSIYWPALNELAQQRRDAYRERWIQGGKQIGEYENYLKGVDIPSVSQVATPSVTGNMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDI0</accession>
    <name>A0A9W9XDI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II beta 2 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_004241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791384.1">
        <property type="nucleotide sequence ID" value="XM_056933843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDI0"/>
    <dbReference type="GeneID" id="81624092"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038816">
        <property type="entry name" value="Stationary_phase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42342">
        <property type="entry name" value="STATIONARY PHASE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42342:SF1">
        <property type="entry name" value="STATIONARY PHASE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5489351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="49016" checksum="02298E38E64443EE" modified="2023-11-08" version="1">MAPANGHLLLPKIWRAARFAYERASKAIRAKIPESTTYSHLRYQPVYARINGSQPINRAAAIRQARSRYFSTRAAGAFVSAIRSGVSAEAHAYRTTRVASNISKLTSRAPFASTLRPNLTGGTLGRTAGGYTLGAGRFGGARYFSHGPAAPAQVIHNVSQGIRVFFLSGQKVRFDGVDPRTGEKRYKAVSGLQDQAGRKMTAVPRKATGSSLDFQVSPTMAAFGAFSALSKQSDAEAVNTLNSDGVMDVLSVDFARALKEYAVVLNDLKRLSTLGDLPVTLHDRSTIRVRFPGCDADTVEHLCDEVGVQRGRITQDEDFEIRTGADLALLFPFAPSVASSETEYLFENSSLPKTHISNDIDWHGMITPEIGSPFAGDSGVESGKAISFEDKELFGSNPWTSPRSAYSSINISELGDQPFFPESNAEQMEFTSDDDADGIHRFIAECDRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDL1</accession>
    <name>A0A9W9XDL1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_003808</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790951.1">
        <property type="nucleotide sequence ID" value="XM_056933410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDL1"/>
    <dbReference type="GeneID" id="81623659"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="27"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5488918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="338" mass="38037" checksum="7B33D0410AC4C9B5" modified="2023-11-08" version="1">MDHISTQGALFAPGMFYSPISSTTGLPQTPFPWTPSSTIAAQDTHHNGNGPDNASRSPTRKPSQTNDKRASKAMKGRRVHACEFPGCDKIFTRAEHRRRHELVHKSKKAHMCTFVGCHKSFHRPDYLMQHLARHGGVPVSTMKKPPLAKRPKSTKCSTPDSVQSQLPTTTTMMSSGMLNSVEENESSAHAFRSLGRYHTPDVESDTFEQPHHEFSAESFHLDAYLTMTHPNHPWPNPKTSHSPGSQNPAASFPTLRHETDLDRYSRRMFQPHAYLSPPPSLSPRLQVAKHIPLPYWYNDIDNTLPPIDPALFSSEVPYLRWPSESNEIRSANIDPRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE47</accession>
    <name>A0A9W9XE47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alpha-1,2-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_003957</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791100.1">
        <property type="nucleotide sequence ID" value="XM_056933559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XE47"/>
    <dbReference type="GeneID" id="81623808"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5489067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="55600" checksum="7BAC479F4E4855FB" modified="2023-11-08" version="1">MAVLRPGRLRSLLLAILASILVCTVYVYWTPTTAASSTVPVVPSTAFEVPLAERQKDFWKALQPLLDQHHPNCPSPMKEGDAAANHFDPNQDAPRPDMTVMSEDDQKAMENAHTRFVEAIRNPPKALKPVHTPGKRGLVSTAGAKYLPVFLSSLRMLRRAGSTLPVELYMKDASEYEKKICRDVLPEFDAQCIVLADVMGKSAIEHYQLKIFAVLFSSFEQIVWMDADCFPLGKPEDLLHSEPFVSTGLVTWPDFWASSVSPLYYKITRQEAPPLTVRQSSETGVFLVSKQTHLQALILAAYYNFYGPSHYFRLLTQGGPGEGDKETFLHAAMALGAPFYAVSDRVQAIGHQNGGKLSGSAMVQTDPREDYALTTQNKWRVKDPSVAPAPRLFFIHANYPKFNPGDNVFGLGWETTPTIKADGSDSRAWTAPSDTLRRLGYDAEKAYWEEIKWVTCHLENVFESWKHKAGLCIKVEDYWNNVFAEPHNDDPVFSQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEK3</accession>
    <name>A0A9W9XEK3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_002358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791920.1">
        <property type="nucleotide sequence ID" value="XM_056931961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEK3"/>
    <dbReference type="GeneID" id="81622210"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000018">
        <property type="entry name" value="Heme/steroid binding domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF76">
        <property type="entry name" value="CALCUTTA CUP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="92"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5490791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="253" mass="28315" checksum="008A1663245242E3" modified="2023-11-08" version="1">MSELRQRQPGISAERNSREAPVARRQKGGCADAAQSNGISILDILRVLATVVIASCGLSYYITNSESFLWGYRPWFTRWPVVKTYLTGPVNLTPAQLSLYNGSDPHLPIYLAVNGSIFDVSANPAIYGSGGSYNFFAGRDATRAFVTGCFQEDLTPDLIGAEERFIPVEDVEGEKITNAQKKIRREREMRLARTAVEQTVNRWESFFRNHKKYFQVGKVVDDGTEDPLKGKRALCEGAVQQRPKRSEMEEGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEM3</accession>
    <name>A0A9W9XEM3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_002388</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791950.1">
        <property type="nucleotide sequence ID" value="XM_056931991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEM3"/>
    <dbReference type="GeneID" id="81622240"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.140.10:FF:000001">
        <property type="entry name" value="SPE3p Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030668">
        <property type="entry name" value="Spermi_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000502">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="11"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5490821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="292" mass="33050" checksum="2592671DEDFFF5EF" modified="2023-11-08" version="1">MSEITHPTIKDGWFSEQSGMWPGQAMNLKVNQVLHHEKSKYQDVLVFESSDYGTVLVLDNVIQCTERDEFSYQEMITHLAMNSHPNPKKVLVIGGGDGGVLREVVKHESVEEAILCDIDEAVIRVSKKYLPGMSVGFKHPKSREYVGDGFEFLKNHKNEFDVIITDSSDPEGPAETLFQKPYFELLNEALRDGGVITTQGSENQWLHLPLIADLKKACGEVFPVAEYAYTTIPTYPSGQIGFMVCCKDATRNVREPVRSWTREEEEKLCRYYNADIHRASFVLPNFARKALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF74</accession>
    <name>A0A9W9XF74_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_002578</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792140.1">
        <property type="nucleotide sequence ID" value="XM_056932181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF74"/>
    <dbReference type="GeneID" id="81622430"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF38">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="517"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="537"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5491011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="71703" checksum="725B8425A1607171" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFI0</accession>
    <name>A0A9W9XFI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_002871</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792433.1">
        <property type="nucleotide sequence ID" value="XM_056932474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFI0"/>
    <dbReference type="GeneID" id="81622723"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF3">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE AN0832-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="15">
        <location>
            <begin position="41"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5491304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="498" mass="55644" checksum="C2B81A572277B40E" modified="2023-11-08" version="1">MRVKTCARPGDTSMDPADIVINAVDPCHIRLVVSGTSCDKYPAKQHARNVASRLGVSHGLIFIAGEPTANWRDSDQSRPFRQRRYFYYLSGVGESDCALTYDIGQDVLTLFVPDFDLRRAIWMGPTLSREEARDRYNADRVMYQSSLVPELVSWLGKRPQDSLLYMVHNSEIPEGLSADLPVDTDSLRPAMDAARGVKDEFEIRMIRQANRVSALAHRQILQNIHQMSNESEIEGSFLNTCISHGAPNQSYQIIAASGPNASVLHYVRNNESLKNKPLVCLDAGAEWQCYASDVTRTFPLGGEWPSKYTRDIYRVVERMQEECIKRIRPGTRFLSLHDLAHEIAIIELLHLGVFKGGSLSEIRESGASKVFFPHGLGHHVGLEVHDVSESSIMALHPDFDHDQYGPILNPLAEGMVVTVEPGIYFSALALANARKQPHAKYIDFEVAEKYVHIGGVRIEDDILVTRNGYENLTTAPKGEDMLAIIRESARKACKESGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFL1</accession>
    <name>A0A9W9XFL1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792478.1">
        <property type="nucleotide sequence ID" value="XM_056932519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFL1"/>
    <dbReference type="GeneID" id="81622768"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000074">
        <property type="entry name" value="Phosphoglycerate mutase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF51">
        <property type="entry name" value="TRANSCRIPTION FACTOR TAU 55 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38373" checksum="59686ED86F20A1DA" modified="2023-11-08" version="1">MPLDTIYLTRHGHRLSWTIDFRTGTYRSQFPTPTGNPADPALTSHGVRQSHELSAHITSPEFHPKPFRVYSSPFYRCLQTIQPSVEALKKKKQNESSSLEKSVGDHAQLDPAADFDVRIENGLGEWFGPTTFFDHPSHPTPGMMQTHFPSILPASPETKYTPLLHPSTRGETIAQLHDRVATALEGIIADVDAEITALEAHLPQDQRTSKSILMCAHAAPLIAMGRVLTGNMPEDSSEEDFFVFTAGMSTFKRRMIRDRDQSRPLSLLADGTRFVRCEGVPAWEDGRGVGGGWTCVKNGDCTFLSDGAERGWHFNGDESFDTGVMAPPSEPPALASSSPAESVRSTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFT1</accession>
    <name>A0A9W9XFT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">N7539_003006</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792568.1">
        <property type="nucleotide sequence ID" value="XM_056932609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFT1"/>
    <dbReference type="GeneID" id="81622858"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Pex N-terminal" evidence="18">
        <location>
            <begin position="40"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ5491439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="413" mass="45587" checksum="1569EFF2780C38B5" modified="2023-11-08" version="1">MADDDPHLSLTTPDAPIGSPTSHFYPFATSPDIIRAHEKDAFLTSGLVQQVQSIIRALRGARYAHTHSDAIKHLTELLYFSLTTAIGNRTLGEEYCDLVQLEDDTLRLPAITRRVGYILSSILVPWSLQRLLPSLRQRVRHKLERSVAKQQLREAQQASLLSLNKPSLSTHTAGGTASKPFFTKLRVQQYLLEHLDSITSVSPIYALSLATFYFTGSYYHLSKRIWRLRYVFTKKIEESEQRIGYEVLGVLMVLQIAVQGFLHVRKLATSMQEEQAESATKTGETSSSEAGSLLATIENPSTVPLLPASSARYDLDENPGGRGVDSRRSATEVYAVFGSFQGSKCDDLRACLLLGVCPRLGAREAGVSPLSAGGAYFKGTAVAGVERRELSPSFLMYILVLSMFAGNRTVVWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGH5</accession>
    <name>A0A9W9XGH5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin cortical patch SUR7/pH-response regulator PalI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792953.1">
        <property type="nucleotide sequence ID" value="XM_056930922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGH5"/>
    <dbReference type="GeneID" id="81621171"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414:SF1">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27309" checksum="F3D719AFA840FD8C" modified="2023-11-08" version="1">MLLSRATLGLLGLFFTAGSIVLIFLTFLGGVNNHTPLNQIYFLQADTGNIPGAPTTSRWTFWNVCGVDNNGHNLCGAVHPDFPLDPPNSNNFGTEQNVPGQFIGTKHYYLMTRFMFPFILIGLFFTVISLFTGLLAMCTRIGSYLSGLLAWLGLTFQTITTSLMTAAYVQGRNAFQSNGQNAKVGVKAFAFMWTATACLFIACMMYCAGGAVGRKDRSGYSGRTERRRGFFSARSNSLRSQKKEESSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHD2</accession>
    <name>A0A9W9XHD2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purple acid phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792760.1">
        <property type="nucleotide sequence ID" value="XM_056932801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHD2"/>
    <dbReference type="GeneID" id="81623050"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF145">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041021651" description="Purple acid phosphatase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="7">
        <location>
            <begin position="31"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="168"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="6">
        <location>
            <begin position="426"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5491632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="551" mass="59390" checksum="F2800098A1919057" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHG2</accession>
    <name>A0A9W9XHG2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Translin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_001814</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793448.1">
        <property type="nucleotide sequence ID" value="XM_056931417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHG2"/>
    <dbReference type="GeneID" id="81621666"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14819">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.200:FF:000002">
        <property type="entry name" value="Putative translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5493068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="239" mass="26948" checksum="1FCF1B63D9133BF3" modified="2023-11-08" version="1">MIDQRIFEDLQAKIDEETTVRDELHEIVQTLARKGRSTQAILSRAHSTPADQLEQPVKPVLDDAAVEILAQKHEVLRLKAVADQHPFYKYNGLWTRELQNLVTSIELCAWLGGLQEYKSSDSGSFLTIEEVGKFLEVPVNLKEQDAFHLTIEEYLLALISVVEELSRLAVNSVTLGDYERPLQIGNFIKDLFAGFQLLNLKNDILRKRSDGIKYSVKKVEDVVYDLSLRGLVPKGSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHG9</accession>
    <name>A0A9W9XHG9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793085.1">
        <property type="nucleotide sequence ID" value="XM_056931054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHG9"/>
    <dbReference type="GeneID" id="81621303"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055589">
        <property type="entry name" value="DUF7165"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23749">
        <property type="entry name" value="DUF7165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="11"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="719"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="882"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5492705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="931" mass="102575" checksum="C72C5DA0CC7D6864" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHK5</accession>
    <name>A0A9W9XHK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_001872</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793506.1">
        <property type="nucleotide sequence ID" value="XM_056931475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHK5"/>
    <dbReference type="GeneID" id="81621724"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000030">
        <property type="entry name" value="Mitochondrial large ribosomal subunit L49, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5493126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="182" mass="20268" checksum="8C4040174DE7ABC5" modified="2023-11-08" version="1">MASFRQSASVASSNFRLAQSVASVQTCSRFSPVYSFSHLRASYRSSTPQISPPAQQSRGFLTQLRREAQALKEQPISQTAPLPKNGKQLTPNLSLTNLPYFVRRTGSNQLPVYLVTKAGGTKQLTKIQKTEGDLDAFRNDLAISLGIDTRSTDVSVNRLTGHIIVKGWRKPEIVRFLQERNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHK7</accession>
    <name>A0A9W9XHK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-haloalkanoic acid dehalogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793383.1">
        <property type="nucleotide sequence ID" value="XM_056931352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHK7"/>
    <dbReference type="GeneID" id="81621601"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF4">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26892" checksum="EC56406F3C7AA3E4" modified="2023-11-08" version="1">MPVEKHVVFDVVGTCVSFDAFYNGIDKVIGQRLLKHNITARSFGFTWMTAAELEFTFLSISERYKPYKEIMLALFFRTLYMMGVEDPRSFATEAERDQCTQGYSELELRPGAKECFAKLRDSGFTVWCLTTGDTKRVRGYFERGGVDMPLENFISCDTAGVAKPALAAYRPALAQFGDRDVKWFAAAHMWDVTAAVKVGFRGAYCTVYEKESCAEIFDVNLEVTADSLPAMADMIIAASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHU2</accession>
    <name>A0A9W9XHU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_002027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRP1/MDG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793661.1">
        <property type="nucleotide sequence ID" value="XM_056931630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHU2"/>
    <dbReference type="GeneID" id="81621879"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF81">
        <property type="entry name" value="CRUCIFORM DNA-RECOGNIZING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="3">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="569"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="618"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="653"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5493281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="697" mass="72021" checksum="8266CC56636A65EA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHW0</accession>
    <name>A0A9W9XHW0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793210.1">
        <property type="nucleotide sequence ID" value="XM_056931179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHW0"/>
    <dbReference type="GeneID" id="81621428"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="255" mass="28615" checksum="76B05D793D77AC37" modified="2023-11-08" version="1">MPGTMSSSSEAPQDTSGACVENHPRPVVLILSGQSVFAESHNTAPLHEISSDVCSVSNKNASVRFERVEQSVQDETNEDKLMPAPPRRHLFYLVHPSNAQYRTDIAAKYYITCVAPEMIGNVRLEVAESRLRRTSFRVMLSANRTASDNPLFDQNEEQSVLFNIRPISQAAHCRYIWSDSNGSEVAKDQRTGGTHKLALSGPLSQQLRDMIVAAWLLRLWYDTAESRQAKKQFFESMASVEGSTDPYMKRQCDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLK2</accession>
    <name>A0A9W9XLK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conidiation-specific protein Con-10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794239.1">
        <property type="nucleotide sequence ID" value="XM_056929946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLK2"/>
    <dbReference type="GeneID" id="81620195"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019626">
        <property type="entry name" value="Stress-induced_KGG_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10685">
        <property type="entry name" value="KGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="16731" checksum="99AA2660B1F9F02E" modified="2023-11-08" version="1">MIRPTLSQAPSFKVRCFTVSLHHMVVTAPPPKHPNPSNFANRSREEMSKIGHRGGKKSGKARGVGGFHDMDPEKQVGQPDSVGQSYYIERPAIRDLATKHAIASRGGRAARKVAEQSSEALGQSQSSGAQKHQSGRRSHEPPIIAPTFEEWQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM46</accession>
    <name>A0A9W9XM46_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_000610</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794507.1">
        <property type="nucleotide sequence ID" value="XM_056930214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XM46"/>
    <dbReference type="GeneID" id="81620463"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5495494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="486" mass="55872" checksum="F25ADC24177BDF7D" modified="2023-11-08" version="1" fragment="single">RHRESHLVLPFHSLASRLSHPVHFLADLWPSSLEDIPVLLCECHSLTLLRLPMTPQQPPFQCDFPGCSLSYRRKEHLTRHAKSHIQPRSYECPFCDRVYARNDTRRQHIRTHHKNKECQSSRAVRACQYCRLRRSKCNGQSPCDACSQRGKQCLYSQNSRRRVLEQRKSPNDDTSLTAFSELDSAFSTTSFAGGPSSIQHAEVTENNSCRTAPYVEAYFEIFHRHWPLLHPATFDPGREPAFLLQSVIMMGLWVTGESNARQTAKVLHQKLSLLIYEQKEIWDTSNHHDESQRQPNDTSSPEPTPWPMATYQGILLHLIFSLLISQDQLDLQLTHALPELPSRLLVALVRSCLKRNMFFYPSMLTQFKPGVDPDVFIWLGIEEIKRFCLSLYRVCRQCRVFDPKILEDAPTFSARRGPRAPGERLLSLTDLQFALPDSDELWDATSGLAARLAENPAACHNANVEEKWISQTARLLQPRDAQVQWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM88</accession>
    <name>A0A9W9XM88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056929815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XM88"/>
    <dbReference type="GeneID" id="81620064"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="237" mass="25213" checksum="382246A4CA338550" modified="2023-11-08" version="1">MGDFTLFNGQLYTPGLAIVDAPQPYTTLGGQNLQVAIDVSGNGKLSWPPSTQSPDAPTLFHNITLFLTSETLSHNFTISNGTTPAHNGTGYVGPVLDLEPSSTVKHVNWVWPSCLVGDGSSTKDGSARGAYNISMHQSFRWNGTDYYTVFDFPISVTNSIPKSDERVDCASLENKLLSAAEVDKSSDRLPGQPWLQNGTQTQSASASPSATGAASRKETMLLFATVGAALTALLHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMI2</accession>
    <name>A0A9W9XMI2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794700.1">
        <property type="nucleotide sequence ID" value="XM_056930407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMI2"/>
    <dbReference type="GeneID" id="81620656"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="103" mass="11334" checksum="2AB357D91345F12D" modified="2023-11-08" version="1">MQQVTKNLSDTGSPSSAGESEVSELNRTNGLDVLGYAVVVTKREAALCDTSQENLAEMAVYGNIVVKRVESKWLSILASLYWRAVRQEAMCDILQALERRNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMN9</accession>
    <name>A0A9W9XMN9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_000912</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794809.1">
        <property type="nucleotide sequence ID" value="XM_056930516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMN9"/>
    <dbReference type="GeneID" id="81620765"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF416">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE GODZILLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5495796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="219" mass="24433" checksum="48D8592101F3D4CF" modified="2023-11-08" version="1">MATYETEHDTTDPAFANDGPRRRRPDLSTFFATLSEITPGPDHRPHAVPVPGDVSAAFYSLAEAFEVMRRDASTTAAQSGDGSNGDELLTQMIQTLLSEADTPPREVEGVSEEFCDTADGSAPVMTTVLDRVPKSSLDKSQVCPICNNPFLEDEYPLVVRLPCHPTHLFDLECVRPWLRLRGTCPLDRTDFAKQLRDKDAERKKLVEEDDEEEWDGMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMR2</accession>
    <name>A0A9W9XMR2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-binding protein RAP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_000909</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Chromosome</location>
            <location evidence="8">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794806.1">
        <property type="nucleotide sequence ID" value="XM_056930513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMR2"/>
    <dbReference type="GeneID" id="81620762"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070187">
        <property type="term" value="C:shelterin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031848">
        <property type="term" value="P:protection from non-homologous end joining at telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11655">
        <property type="entry name" value="rap1_myb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021661">
        <property type="entry name" value="Rap1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038104">
        <property type="entry name" value="Rap1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039595">
        <property type="entry name" value="TE2IP/Rap1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015010">
        <property type="entry name" value="TERF2IP_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466">
        <property type="entry name" value="TELOMERE REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466:SF6">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08914">
        <property type="entry name" value="Myb_Rap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11626">
        <property type="entry name" value="Rap1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="2 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0779">Telomere</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BRCT" evidence="10">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="155"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5495793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="466" mass="51092" checksum="614DC17E7C427D5C" modified="2023-11-08" version="1">MPNLFGGARFFLSHAVPQRSQLRLTIEQNGGTVVLLEKDADTILVDHLKKSQTHPANALSYQFVEKSVRNGKLEDPELYKVGPSPARPLGASNIPTKSTKRSYSLEDDRIVFDWLYPLEQTPGAPTHGTSIYKLLAERFPQHTWQSWRSRYLKTLRGKPRPGGGEPRPDLVYGGPEAVPGCKKPVTTPQPPQAGSLATGRSPAAATSKELGKSASRPVNNQSGSKLSTKPEVSARKREPPLTSSLETSGAAKKARKGPDKATPSSAVAVQSPPAQTPLKAKELARTPSKEEVQTEGAQAPNGVQETIPLENVPTLDQSLKRPAKDQVEEHADPLFQHLPFFPTSSDSGSDDSGSEDADDDSDPEEYPDLRSWVNAQVAKGVDGPTVLNALRYTSMEPRPAKKLLQILVDGNSVPQNMRGVWTEEDDRCLQSRDAHDVERVVMKHGDRLFKARWEYLEMARERGLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMZ9</accession>
    <name>A0A9W9XMZ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="15">2.7.7.1</ecNumber>
            <ecNumber evidence="15">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_001014</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="15"/>
    <dbReference type="EC" id="2.7.7.18" evidence="15"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794911.1">
        <property type="nucleotide sequence ID" value="XM_056930618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMZ9"/>
    <dbReference type="GeneID" id="81620867"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09286">
        <property type="entry name" value="NMNAT_Eukarya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000074">
        <property type="entry name" value="Nicotinamide-nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045094">
        <property type="entry name" value="NMNAT_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 15 18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 15" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="17">
        <location>
            <begin position="52"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004658"/>
        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048721"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5495898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="286" mass="32119" checksum="FB90841EB1B219CD" modified="2023-11-08" version="1">MTTATEMVGGQSDDVHQPPAHIPPAPMGDYVFPELRLKRKMNDPEKTPLLLVACGSFSPITYLHLRMFEMAADYVKFSTDYELIGGYLSPVSDAYRKAGLASAEHRVAMCQLAVDQTSDWLMVDTWEPNQKEYQPTAVVLDHFDHEINTVRGGVETADGSWKPVRIALLAGADLIHTMSTPGVWSQKDLDHILGKYGSFIVERSGTDIDEALASLQPWKENIHVIQQLIQNDVSSTKIRLFLRREMSVRYLIPVPVIHYIEQHHLYEDDGTSNEKGKERQDAGKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJK3</accession>
    <name>A0A9X0BJK3_9EURO</name>
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        <recommendedName>
            <fullName evidence="10">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_009304</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
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    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056938899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJK3"/>
    <dbReference type="GeneID" id="81629149"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
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        <property type="entry name" value="FI21118P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5469686.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="737" mass="81481" checksum="24BF26D67B054A8F" modified="2023-11-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BLQ9</accession>
    <name>A0A9X0BLQ9_9EURO</name>
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        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">N7539_008534</name>
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            <authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Frisvad J.C."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
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    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAJ5471965.1"/>
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            <end position="226"/>
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        <location>
            <begin position="5"/>
            <end position="32"/>
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    </feature>
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        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5471965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="758" mass="85786" checksum="C14A6203236376A0" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BM42</accession>
    <name>A0A9X0BM42_9EURO</name>
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        <recommendedName>
            <fullName evidence="1">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
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    </gene>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
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        <property type="entry name" value="BLR2777 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36151:SF3">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="1">
        <location>
            <begin position="15"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5472058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="111" mass="12283" checksum="3BC2B6F6D39B2BE7" modified="2023-11-08" version="1">MSTLKSQYEQIVSKSICLMDGGLALMMQIARSQVAAAVAIHSRFEKNAQQRAISSLEYINIVLLGEDEEIGDICERVRRIHDGVQGAEGDESYSTSDSELQNWVAGTIYWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BN24</accession>
    <name>A0A9X0BN24_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_008205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786897.1">
        <property type="nucleotide sequence ID" value="XM_056937805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BN24"/>
    <dbReference type="GeneID" id="81628055"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07114">
        <property type="entry name" value="ALDH_DhaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5475139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="522" mass="55680" checksum="55D6410C3FCD5BD2" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BN40</accession>
    <name>A0A9X0BN40_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peroxisomal membrane protein PEX13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Peroxin-13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_008351</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts (via SH3 domain) with PEX14 (via SH3-binding motif); forming the PEX13-PEX14 docking complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxin-13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787043.1">
        <property type="nucleotide sequence ID" value="XM_056937951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BN40"/>
    <dbReference type="GeneID" id="81628201"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11771">
        <property type="entry name" value="SH3_Pex13p_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000128">
        <property type="entry name" value="Peroxisomal membrane protein (Pex13)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007223">
        <property type="entry name" value="Peroxin-13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04088">
        <property type="entry name" value="Peroxin-13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="130"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="202"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5475285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="264" mass="28688" checksum="3DCC0111AF6ABAD5" modified="2023-11-08" version="1">MVSVAEQFGNLRNTLGSALGIFTIIRWFRTLIAKITGRPPPADATALTPAAFAAFMGGRSASGTLPDGSPAPAKPSKKPFFMFLIAVFGLPYLMGKLIKALARSQEEEAKRRQQMIGPNGEPQSGVMDPAKLDFCRVLYDYSPETQESNGIDLAVKKGDIVAVLSKSDPMGNASEWWRCRARDGRVGYLPGPYLETIQRRPAQQAITTGSEPATRTSTMKSSAAHERTQSLTTLTKPANEQPPQLKGKMGDITPESFQKSTFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BN89</accession>
    <name>A0A9X0BN89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peroxisomal membrane protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786866.1">
        <property type="nucleotide sequence ID" value="XM_056937774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BN89"/>
    <dbReference type="GeneID" id="81628024"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019531">
        <property type="entry name" value="Pmp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460:SF3">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013674">
        <property type="entry name" value="PXMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5475108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28177" checksum="D002C783C52D8C7A" modified="2023-11-08" version="1">MDALTSRLDALVLNPELAPLLSLVKGARNGIVYGSKVRFPHALVMIFLFRSGTFREKVKLVLNATRLHARNLATFATIYKASMIILRNLPAGQGKEGRYDSFFAGLLGGYAVFGRQRGSISQQVCRKSPHRGRMEWKGPRVKNRIALPTANSNPYLQIVIYVFARVMLSLAKLSVQPGMHPLSSLITPQARTSITDNAWPVFASMSWALVMYLFRWYPETLASSLRSSMVYIYADSDHWNSFRNLLIHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNB2</accession>
    <name>A0A9X0BNB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_008430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787122.1">
        <property type="nucleotide sequence ID" value="XM_056938030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNB2"/>
    <dbReference type="GeneID" id="81628280"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF812">
        <property type="entry name" value="VPS9 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="69"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5475364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="293" mass="33071" checksum="40732C79FB19CF37" modified="2023-11-08" version="1">MNFELESARGRDSDKEHHDPTIGWAQPELSFHVTGASDFIASHVVRQLLEKGEKVHATVQNTKNTAKIQHLHGTQNVLDAVQKIESVKTVILTSSCAAIYGDNADMLEMKDRTMTTEYFNTSNFVQHNAYSYSKTVAEQEAWKIYEAQAKPPRCLSLLDQILCGQFFAGVPDLHFALVDVRKVATTHIRAAENADAHGRYILTHDASNSLVDITRMLRPITKLSLVPKHTLPNMVVRLAGPFLGFSQDWLRKNLSISFKADNRPSQEQLGIEYRPLEETVADHYESWKKAKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNY4</accession>
    <name>A0A9X0BNY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_007479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787879.1">
        <property type="nucleotide sequence ID" value="XM_056937080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNY4"/>
    <dbReference type="GeneID" id="81627329"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5477335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="92" mass="9772" checksum="0E9BD6DF8B91C574" modified="2023-11-08" version="1">MLLAEDFSLMLGIRLASEPFVGTARSNVCVAAELSRSTSAMLDRALPFFFQSSSTEEGDGSPAWAKTPFCRPVGPAMVACGDGRAQEVLEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BP32</accession>
    <name>A0A9X0BP32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_007629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788029.1">
        <property type="nucleotide sequence ID" value="XM_056937230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BP32"/>
    <dbReference type="GeneID" id="81627479"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.190:FF:000005">
        <property type="entry name" value="Putative HIT finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5477485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="190" mass="20553" checksum="769451E7D1156458" modified="2023-11-08" version="1">MPGVCEVCSTEPSKYRCPTCSLMSCSLACTQSHKIYCAPKPEATNNVPTTPSDIPAGDLTSGQTNNVPAGDTPTVQVGGTNVATIASSAEVQALLSRYPELRSQLYEIFHATEEDEWQEWYTPSTRGRPHGRGGRGGPSRRSRGAWTAEKGFNRGLGKVRKLRQDCEAGSETGVKAEAFMEFLVLVNKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BS97</accession>
    <name>A0A9X0BS97_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 13">Catalase</fullName>
            <ecNumber evidence="3 10 13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_006784</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 13"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056936385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BS97"/>
    <dbReference type="GeneID" id="81626634"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF1">
        <property type="entry name" value="CATALASE-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="15">
        <location>
            <begin position="34"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5480890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="730" mass="82069" checksum="3E38290EAF833F4D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSR7</accession>
    <name>A0A9X0BSR7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_006258</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788784.1">
        <property type="nucleotide sequence ID" value="XM_056935860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSR7"/>
    <dbReference type="GeneID" id="81626109"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901604">
        <property type="term" value="F:dethiobiotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015295">
        <property type="term" value="F:solute:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905135">
        <property type="term" value="P:biotin import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000399">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000278">
        <property type="entry name" value="Putative MFS transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF33">
        <property type="entry name" value="VITAMIN H TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5482812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="62198" checksum="93036D6BCA5FBB29" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BST4</accession>
    <name>A0A9X0BST4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788905.1">
        <property type="nucleotide sequence ID" value="XM_056935981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BST4"/>
    <dbReference type="GeneID" id="81626230"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5482933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="82" mass="9703" checksum="094AF268FF776632" modified="2023-11-08" version="1">MVHIQWCVEAQKRGGRGICNPCDSNVARKLDKARPQLPCTSQQLSQDLIWIVTVSEKWWRKIWMLDRDEGTMIRDEDSEWVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BT66</accession>
    <name>A0A9X0BT66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_006366</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788892.1">
        <property type="nucleotide sequence ID" value="XM_056935968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BT66"/>
    <dbReference type="GeneID" id="81626217"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07959">
        <property type="entry name" value="Anticodon_Ia_Leu_AEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="68"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="225"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="844"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="13">
        <location>
            <begin position="992"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5482920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1127" mass="126887" checksum="EA68D0F5F242BCC8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BU03</accession>
    <name>A0A9X0BU03_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tripeptidyl-peptidase sed1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_005989</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789463.1">
        <property type="nucleotide sequence ID" value="XM_056935591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BU03"/>
    <dbReference type="GeneID" id="81625840"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
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            <end position="649"/>
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</entry>
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</entry>
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            <begin position="108"/>
            <end position="242"/>
        </location>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5484830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUX2</accession>
    <name>A0A9X0BUX2_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="2 3">
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    <reference evidence="2" key="1">
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                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790452.1">
        <property type="nucleotide sequence ID" value="XM_056935258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUX2"/>
    <dbReference type="GeneID" id="81625507"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF11">
        <property type="entry name" value="NACHT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G01490)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="648"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="985" mass="101615" checksum="7FDA611D85D9D7F9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUX6</accession>
    <name>A0A9X0BUX6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="6">M1Pi</shortName>
            <shortName evidence="6">MTR-1-P isomerase</shortName>
            <ecNumber evidence="6">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MRI1</name>
        <name evidence="7" type="ORF">N7539_005671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUX6"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000002">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5485683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="386" mass="40577" checksum="A413D31E6D81C4A0" modified="2023-11-08" version="1">MLQAIKYDQGNLEILDQLQLPFVEKYIPIRTAEDGWNAIKDMKVRGAPAIAIVAMLALASELHTLQSAEKIPASSEETKALIAKKLEYLVTSRPTAVNLADAAQKLGAVVTSQAEQSGATGQSVVSAFIRGAEEMMGKDLEDNQRIGHHGAEWIMANATKLGVSDVAVLTHCNTGSLATSGYGTALGVIRSLVSKNNLRHAYCSETRPYNQGSRLTAFEFVHDKIPATLITDSMAAALLADPKAGVNAIVVGADRVAANGDTANKIGTYSLAVLAKYHGVKFLVAAPRTTIDLATKSGNEIVIEQRPAAEMTNIKGPRAGAPAVDGNVALETVSIAAPGINVWNPSFDVTPAALIDGIITEVGVVEKGSDGLFHMEVLFNGAAPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BV12</accession>
    <name>A0A9X0BV12_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_005495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790291.1">
        <property type="nucleotide sequence ID" value="XM_056935097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BV12"/>
    <dbReference type="GeneID" id="81625346"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF63">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5485507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="279" mass="29603" checksum="5905B751E229FF15" modified="2023-11-08" version="1">MSTSKGRLQGKNAIVTGAAGGIGLETTILFAREGANILLADISEPALAKALNKVKEVVPNAGRLETIRCDVSKEADVQAMVESVDSWGGADIVFNNAGIMHADDADAVDTAEKIWDLTQSINVKGVWFGCKHAVLSFRRNNKKTASVINTASFVALMGAATPQLAYTASKGAVLAMTRELAIVHAREGFRFNSLCPGPLNTPLLQDWLGDDHAKRFRREVHFPSGRFGEAVEQAHAVVFLASDESSFVNGTDFVVDGGLSKAYVTAEGPAPAAPKNLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXH7</accession>
    <name>A0A9X0BXH7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790522.1">
        <property type="nucleotide sequence ID" value="XM_056932981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXH7"/>
    <dbReference type="GeneID" id="81623230"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5488489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="72" mass="8032" checksum="AE1E9F955EB4A218" modified="2023-11-08" version="1">MVRSEAVRETLGLHVPWVLINRSHSKSSTHVTREALTGTLDVDAETRSIEVVIEPEAWMQSATQIDSHCSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXS3</accession>
    <name>A0A9X0BXS3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_003945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791088.1">
        <property type="nucleotide sequence ID" value="XM_056933547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXS3"/>
    <dbReference type="GeneID" id="81623796"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000016">
        <property type="entry name" value="60S ribosomal protein L4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5489055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="285" mass="32245" checksum="1CF093F618C4FAA2" modified="2023-11-08" version="1">MPGGETFRALRMLSRSSCGLLSGPENVTRRCLMRSMATDAQIGASSSTDPSTLAPWDRPVNVMTYSFPSMEPVRLVNYSQKELQMPIRKDILHRAIVYEGDMTRQGTASTKWRDDVHGSHRKVHPQKGSGRARAGDKQSPIRRGGGVAHGPHPRDFSTDLPAKLYDQAWRIALSYRFQRGELIVIDDKISLPSNSTPYLLEKILETNNWNTKKGRSTFITSEVDMDLFAKVEKMQRYATIMDRSDVDVKNLLETARLIIEKKALDQILKKHSRDLSSQPAKARYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYE3</accession>
    <name>A0A9X0BYE3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_004666</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791809.1">
        <property type="nucleotide sequence ID" value="XM_056934268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYE3"/>
    <dbReference type="GeneID" id="81624517"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF40">
        <property type="entry name" value="REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14497)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="204"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5489776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="335" mass="37845" checksum="30836AE74B71B709" modified="2023-11-08" version="1">MSHPIDVMIYGLGAIGSFYAFILNRSERVRLTVVARSNYDAVCQNVRLFSPLRLFANLVKSPDEASTMDYIICANKAIDQHRVPAVLKPAVDPDRTSIVIIQNGVGNEEVFREQYPRNLIITCVLKDRMDRWQVDEKTDYLLICQTWVGATQTRPGVVNHTKSENLQIGTFPNPHLDQTIATKRLNEFAALLEHGKTRFQICDDIQQKRWEKVVWNAAWNSLTTLTMVDTQTWLHSSPDAEPFTRKLMFEVITIARACGVPLGDDLIDQQMAKIKAMPGIGSSMQVDRKNGRPMEIDAILGFPLQKAKEHGILAPYLESLCVLLRAIDQKLRAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYL0</accession>
    <name>A0A9X0BYL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial K+-H+ exchange-related-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_002377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791939.1">
        <property type="nucleotide sequence ID" value="XM_056931980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYL0"/>
    <dbReference type="GeneID" id="81622229"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018786">
        <property type="entry name" value="Mit_KHE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062">
        <property type="entry name" value="K+-H+ EXCHANGE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10173">
        <property type="entry name" value="Mit_KHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5490810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31927" checksum="12AF9B95C0C4C3D2" modified="2023-11-08" version="1">MRLFLIPISTKRALIYARPLRRDAAKELSLLDRATSKAAGTWAKWEEAESGWKKHLASWGNRVQQRIPFEEWGLKSIPSLKQQRRIDEHHGTRQIDVLYPANAIRRENIPQMLRKIATERQEFHRKQMWWSLGLSPLTAPFAIIPIVPNIPFFYLVYRGWSHWRALNGSRHLEYLVDNDLITPMSMLDLEQLYATRASRVLNDSPIDTPPAELVEDIEQSDDRVLLKMSDAKKLATMLDAPELALEAERAIVQVTEQLEARRKKDQEAQSEKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ22</accession>
    <name>A0A9X0BZ22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferase-like protein FUS3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_002289</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791851.1">
        <property type="nucleotide sequence ID" value="XM_056931892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ22"/>
    <dbReference type="GeneID" id="81622141"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000142">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF10">
        <property type="entry name" value="ELONGATION FACTOR EEF-1B GAMMA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="91"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5490722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="222" mass="24637" checksum="39DB524E6B2E9382" modified="2023-11-08" version="1">MAPFGTIYSYTPSPRVIKAQAAANLNGLELAIAPDFVMGQSNTTPEFLAKFPFGKVPAFEAADGTLLTESDAITQYIAESGPAAASLLGATPAERAVIRQWICFAQGEVIEPITQLGLWRLKYVPYNEATEKQALQRIERSLSYLETHLKDRTWLATSDKVSLADITVGSSLIWGFSLSIDAEMRNKYPLTMAWYERLTEVEGVKQAFGEKIFVEKREEYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ39</accession>
    <name>A0A9X0BZ39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792017.1">
        <property type="nucleotide sequence ID" value="XM_056932058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ39"/>
    <dbReference type="GeneID" id="81622307"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040906286" evidence="2">
        <location>
            <begin position="18"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5490888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="282" mass="30814" checksum="EEE096E516B15AD0" modified="2023-11-08" version="1">MHSALAALILLSTPIHATITAKVWAHFYPNCPGDPYSTLDAYESYEETAPTKVITAGVCTSFGVPSFNHQLVSSISVDAELTPEDYQNLYPSDTGARCNITVHEEPECIDPALINQELHKGVEVSKCETRSFAAFSQIWIQLNCENDGEALHSNSSLGQSSNSTYESRLADSGGEDDVEAPSKMQTPGSNSNTWANAQTGHASQQDPEQVERVNQDGHAESEKILQDLMERLKNQTATHVSGKSNSTRPVNGTLLQSNGTVSRSPGLIKRRLSVLRRRRTWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZC4</accession>
    <name>A0A9X0BZC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein pacG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_003113</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transcription factor that acts as a positive regulator of nonrepressible acid phosphatase activity. Is a major regulator of responses to nitrogen and carbon starvation and is essential for the expression of genes involved in vegetative incompatibility (like pin-c, het-6, and tol). Vegetative incompatibility is a non-self-recognition system ubiquitous in filamentous fungi which results in programmed cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792675.1">
        <property type="nucleotide sequence ID" value="XM_056932716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZC4"/>
    <dbReference type="GeneID" id="81622965"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1390:FF:000002">
        <property type="entry name" value="PhoG like DNA-binding family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
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    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
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    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN PACG"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="80"/>
            <end position="331"/>
        </location>
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        <location>
            <begin position="80"/>
            <end position="331"/>
        </location>
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            <end position="444"/>
        </location>
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            <end position="531"/>
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            <begin position="339"/>
            <end position="358"/>
        </location>
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            <end position="406"/>
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            <end position="441"/>
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            <end position="506"/>
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            <begin position="512"/>
            <end position="525"/>
        </location>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5491546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="614" mass="66441" checksum="FF804CED8FBBF520" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZG1</accession>
    <name>A0A9X0BZG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_003218</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin-dependent halogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491651.1"/>
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    </dbReference>
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        <property type="entry name" value="FAD-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0274">FAD</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00005706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5491651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="691" mass="77714" checksum="159F88864E1E0ED1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZS3</accession>
    <name>A0A9X0BZS3_9EURO</name>
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        <recommendedName>
            <fullName evidence="8">Polarized growth protein Boi2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_001459</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5492713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793093.1">
        <property type="nucleotide sequence ID" value="XM_056931062.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Polarized growth protein boi2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037370">
        <property type="entry name" value="Pleckstrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
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        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092:SF16">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092">
        <property type="entry name" value="PLECKSTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="16"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="790"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="130"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="357"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="475"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="539"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="970"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="139"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="615"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="660"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="727"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="768"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1009"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5492713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1057" mass="114667" checksum="57F2966A89D8D7C2" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZU3</accession>
    <name>A0A9X0BZU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_001372</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793006.1">
        <property type="nucleotide sequence ID" value="XM_056930975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZU3"/>
    <dbReference type="GeneID" id="81621224"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF803">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="11">
        <location>
            <begin position="11"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5492626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="338" mass="37412" checksum="5133B31FB9B56A42" modified="2023-11-08" version="1">MSSSDALLLFDVGASQAQGSRKFQEDRYTTILPEHFPVNTNENLAFFAVYDGHGSDAVAEHASQHLHHLLAQRTELPRGDYAIAIKAALADEDALLLERFQHESVEPAMSGSTVAMCLINLTEGELVVSNLGDSHVVMAERDPRTGAPFHIVRIVPSWWWSPGPKTIMLTFMGGCHLQRRLTEAHKPDTPSEQARIKEAGGIVEKRNGVSRLGSLNMSRALGDLQYKNPVNSLGEEHTMPRVRRASSSSTPQRGNFVSNEPYTSRRILHAHRRYLLVIVSDGVSDYIDDTVLIQYVMDLSLRGMQATEVAHDVVSRMACRPRSDNASCVIVMLNGQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZX0</accession>
    <name>A0A9X0BZX0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein TIF31 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CLU1</name>
        <name evidence="4" type="synonym">TIF31</name>
        <name evidence="8" type="ORF">N7539_001609</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CLU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZX0"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000293">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000532">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Clu" evidence="7">
        <location>
            <begin position="324"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="985"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="605"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="881"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1187"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="605"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1188"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1208"/>
            <end position="1218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5492863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1261" mass="140044" checksum="091B366E10665763" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C010</accession>
    <name>A0A9X0C010_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication factor Cdt1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_001729</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cdt1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793363.1">
        <property type="nucleotide sequence ID" value="XM_056931332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C010"/>
    <dbReference type="GeneID" id="81621581"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1420">
        <property type="entry name" value="DNA replication factor Cdt1, C-terminal WH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032054">
        <property type="entry name" value="Cdt1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038090">
        <property type="entry name" value="Cdt1_C_WH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16679">
        <property type="entry name" value="CDT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26121">
        <property type="entry name" value="HTH_CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Cdt1 C-terminal" evidence="4">
        <location>
            <begin position="327"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5492983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="479" mass="53389" checksum="F6442DCA39041AD0" modified="2023-11-08" version="1">MPRTSRSTVSLQAQPAIHSFGRATKAGVTPVLSAKKPATLPVSPSKKRKLQELENFDSAGRQSVDVEADTPSKTLKFSQLTVASPRSGHYASPKRTPSRRTRVSTVAATVPEVPDTPSKKRTINLEEAISDAPLAPRAPCVKDFLHLHSAFVQALSIHIAHNGPVSPADFREFLPSVTRIWKKRKVQPKDLQRLLWVWERSIRAKDVAYRLANYGLGKVCLERHVQIDEQPSVLQDAFEQALDLLWEQTEPSLETAKEEDRPALFLESLGLTPIHESLTPLTAFKKGQQRLQDLRSGVIRMKTEKLRAETEASEHKSLASPLNRRQSLLDRIKNKELRQSKLPPAPTKKEMTLRSAADHVEEVAGILALLRPPAYTGTGIKALFASQRKPFKMDTMIDHVRDSVRSPIPREEVEACLEILADPRVAGHWVTMVTVKDIRSVVLKSCKDIEINQLGAKVAQVKAEWEKPSACTPSIILKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0G7</accession>
    <name>A0A9X0C0G7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793828.1">
        <property type="nucleotide sequence ID" value="XM_056931797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0G7"/>
    <dbReference type="GeneID" id="81622046"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="131" mass="15165" checksum="F9E9977B680809BE" modified="2023-11-08" version="1">MEEIGGELQVSRNGGLKMMAGNAEQCGDDDPDREREGKDGRCPRPNQRKAAREWRLKNREPRCRYGVVLVELGWQSWRDEAERRGKRHCALKAEMVRAHRVGRRSVPEAGDGLAECVVMELIQQYLQWLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C200</accession>
    <name>A0A9X0C200_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spermine/spermidine synthase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793979.1">
        <property type="nucleotide sequence ID" value="XM_056929686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C200"/>
    <dbReference type="GeneID" id="81619935"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000288">
        <property type="entry name" value="Spermine/spermidine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037959">
        <property type="entry name" value="MFS_SpdSyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5494966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="60704" checksum="F4382D9DB6DEA47F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2W7</accession>
    <name>A0A9X0C2W7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_000620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794517.1">
        <property type="nucleotide sequence ID" value="XM_056930224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2W7"/>
    <dbReference type="GeneID" id="81620473"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000083">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative (AFU_orthologue AFUA_4G00660)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RESPONSE_REGULATORY"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="610"/>
            <end position="870"/>
        </location>
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        <location>
            <begin position="1112"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="305"/>
            <end position="364"/>
        </location>
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            <begin position="402"/>
            <end position="428"/>
        </location>
    </feature>
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            <end position="1047"/>
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            <end position="1096"/>
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            <begin position="336"/>
            <end position="349"/>
        </location>
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            <end position="415"/>
        </location>
    </feature>
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        <location>
            <begin position="1038"/>
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        </location>
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            <end position="1095"/>
        </location>
    </feature>
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            <position position="1163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50109"/>
        </source>
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            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAJ5495504.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1249" mass="135178" checksum="F53AD2B392ABE7F1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C362</accession>
    <name>A0A9X0C362_9EURO</name>
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        </recommendedName>
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    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
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            <taxon>Pezizomycotina</taxon>
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                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5495789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
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            <end position="594"/>
        </location>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF11702"/>
        </source>
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            <dbReference type="EMBL" id="KAJ5495789.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="65122" checksum="EBB0C05F146F80BA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C3A6</accession>
    <name>A0A9X0C3A6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CST complex subunit Stn1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_001116</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056930720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C3A6"/>
    <dbReference type="GeneID" id="81620969"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
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        <property type="entry name" value="Stn1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10451">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="CST complex subunit Stn1 N-terminal" evidence="5">
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            <begin position="46"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="CST complex subunit Stn1 N-terminal" evidence="5">
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            <end position="229"/>
        </location>
    </feature>
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            <begin position="234"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5496000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="305" mass="35135" checksum="8A6FC3835AB91DF0" modified="2023-11-08" version="1">METTYNADLVFYPAFCFKVSPTHFAWVKMAAADVQRLRRPRSYNGQSIFFYKNHPIRFVCVVGVIIARTDVTRRTILTLDDSSGTTLEICVLHADPKTRDNAHAQMETMHDLPSIPNINGSYQSPITSGSGPRSLTQVQTHTMRPEHVSATDGTILDISSLQPGMRVKVKGTLSQFRSTMQLNLERFTLVRDTNAEMQFVDQRLRFLVEVLAVPWTLSPEEIAQCRADAERGEVKVLKQRERAERRVKRQAEREARDYYHIQKRYEREERKRAKEALLSREDGVKLMRDIQWRKALASNDAGHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKE8</accession>
    <name>A0A9W9WKE8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_009547</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785637.1">
        <property type="nucleotide sequence ID" value="XM_056939142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKE8"/>
    <dbReference type="SMR" id="A0A9W9WKE8"/>
    <dbReference type="GeneID" id="81629392"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005592">
        <property type="entry name" value="Mono/diacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03893">
        <property type="entry name" value="Lipase3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040944574" evidence="3">
        <location>
            <begin position="20"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Mono-/di-acylglycerol lipase N-terminal" evidence="5">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="4">
        <location>
            <begin position="104"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5466591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="294" mass="30501" checksum="032D3B0AF2D4CDDA" modified="2023-11-08" version="1">MMLFGQSGLLVALAALAAAAPTQLAPRAVSSGTLNQLTLFAQYSAASYCTNNVNSPGDAVTCSGGYCPAVQSAGAKTLAEFNNVLDYGDVAGFLAVDSANKLLVLSFRGSRTVSNWIANLDFDQTDASSLCVGCKAHSGFLRAWSVVSDDVMPALTSAMAKYPGFRLVLTGHSFGGAVAALGATALRKAGYSLDLYTYGQPRVGNTALATYMTNQGSLYRVTHSNDIVPKLPPTWLGYTHASPEFWITSGDSAGVTANDITQINGIGSNAGNAGSDGDSIAAHNWYIVNIDGCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKR4</accession>
    <name>A0A9W9WKR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Lysophospholipase NTE1</fullName>
            <ecNumber evidence="3 16">3.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Intracellular phospholipase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">N7539_008891</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the NTE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3 16"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785863.1">
        <property type="nucleotide sequence ID" value="XM_056938486.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81628736"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046470">
        <property type="term" value="P:phosphatidylcholine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000062">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000007">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000013">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001423">
        <property type="entry name" value="LysoPLipase_patatin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056556">
        <property type="entry name" value="NTE1_P-loop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24179">
        <property type="entry name" value="NTE_Ploop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01237">
        <property type="entry name" value="UPF0028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 15 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 16" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11 15 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="18">
        <location>
            <begin position="628"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="18">
        <location>
            <begin position="785"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="19">
        <location>
            <begin position="1164"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="234"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="704"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="15">
        <location>
            <begin position="1168"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="15">
        <location>
            <begin position="1195"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="15">
        <location>
            <begin position="1315"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="15">
        <location>
            <position position="1197"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="1315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ5469273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1467" mass="163006" checksum="F2EE2B41EF98C83F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL25</accession>
    <name>A0A9W9WL25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_009072</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056938667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL25"/>
    <dbReference type="GeneID" id="81628917"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000014">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="182"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
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            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="492"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
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            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="823"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="981"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5469454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1116" mass="124424" checksum="97E32725C47D0E15" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9W9WQN3_9EURO</name>
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        <name evidence="2" type="ORF">N7539_008485</name>
    </gene>
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    <reference evidence="2" key="1">
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            <authorList>
                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
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                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    <dbReference type="GeneID" id="81628330"/>
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            <begin position="79"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="271" mass="30211" checksum="08990F64EEF8A245" modified="2023-11-08" version="1">MFNMMQEADEVIVVTGEQSTRSESMDKKLIGVDGFWPRRIALPHLAPPRVLAHLTGTSVIQSIFTRHNRLRRIDISHATEKATAKLLMTLMRDSAISGRRLRDAHEEVGRYLAVEYLTAVVGLESYPLQHVQGHITNGYRLFRETETLIVALMRGGEPMALGISQAFPSAMFLHARKLQDICDKSLEGMVTVILVDSVINTGNTILEFVRHIRTLHASIRIVVAAGVIQASLLQRSRVAQQLVAFEQLTFVPLRISENSYSGKGRTDTGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQV1</accession>
    <name>A0A9W9WQV1_9EURO</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786551.1">
        <property type="nucleotide sequence ID" value="XM_056938169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQV1"/>
    <dbReference type="GeneID" id="81628419"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5472005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="122" mass="13927" checksum="8470FFD15E4AF699" modified="2023-11-08" version="1">MALKTHFEILHVRLKSFFDTLHKKLKTLLQREQDLINVRPDSWFLPWDTDPEAPTSTRVNTHSQASVDSRGLPVSYLSAPWDICATPNTYESDEYEPPAPYMYSCNTTPSLPPLASVHLRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQY7</accession>
    <name>A0A9W9WQY7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PARP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_008631</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056938226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQY7"/>
    <dbReference type="GeneID" id="81628476"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="167"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5472062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="282" mass="32081" checksum="DD3F4D5422551248" modified="2023-11-08" version="1">MARYNVDIQCRDARLMHRHARGRATLNRVTITRVVFATISIGTRLPVLTLLVLLAEVSPDSAGCHNKECRDHNIEITKGEIRVGTWVEKFKSWRWRHWGCTTPLVLANMIKNLFGKEELKGDEDFDRIVGWKGLSKTQQDAVRKALTERHIPDEDWKGDVECNRPGKRGFRLSKKKARAKKDADEYSQSSEAEAGERTKMTALAKKATDENDNIGKSRKLKPHTRGGKPEKKPVVDDSANEDANRYVRVEGRFFITTICPYCGCSSQERKPFDTAQTHTKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WR58</accession>
    <name>A0A9W9WR58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_008692</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786669.1">
        <property type="nucleotide sequence ID" value="XM_056938287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WR58"/>
    <dbReference type="GeneID" id="81628537"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF182">
        <property type="entry name" value="POLYAMINE TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5472123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="346" mass="37999" checksum="2FA159486A61ECDF" modified="2023-11-08" version="1">MGCFAKNYCTIAVSRALAGVAGSPSVSVFAGVLNDMWNIPSDRLGVLAFVMYGLGGAIAPSLGPIVGESIVATYGWRSSFWLTSVLAGSCFLGMVFTPETFQNEIMRQKQNAPRRGLVKALVPALRRPLELLWFEPVIWPTALIVTTSQIVLFILYVSLPVVLKQTYQFSPYHVGLAFLPFMVGTLLAVPALAMQDRRKRSLPQPAPEDSLVGVKVAGILLPISLIWLGWTMRPTVHWIWPLLSLVAHGWSFAMEQLSYPVYKNEIYGIEYGASSLAVDIAMRYLLSSVFPLFTAPMIDWMGFSWLMTTKRENRGVHEAESRPSMALPKRPSAGTVTVTITATGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WRL8</accession>
    <name>A0A9W9WRL8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_008622</name>
        <name evidence="5" type="ORF">N7539_008718</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786599.1">
        <property type="nucleotide sequence ID" value="XM_056938217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WRL8"/>
    <dbReference type="GeneID" id="81628467"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051631">
        <property type="entry name" value="Ankyrin-KH/SAM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206:SF8">
        <property type="entry name" value="ANKYRIN REPEAT AND KH DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206">
        <property type="entry name" value="MASK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5472053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5472149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="521" mass="57903" checksum="CF3B044777C62617" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WT16</accession>
    <name>A0A9W9WT16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vesicle-associated membrane protein-associated protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_008045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5474979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786737.1">
        <property type="nucleotide sequence ID" value="XM_056937645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WT16"/>
    <dbReference type="GeneID" id="81627895"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160219">
        <property type="term" value="C:cortical endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140506">
        <property type="term" value="F:endoplasmic reticulum-autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160214">
        <property type="term" value="F:endoplasmic reticulum-plasma membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033149">
        <property type="term" value="F:FFAT motif binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051685">
        <property type="term" value="P:maintenance of ER location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902647">
        <property type="term" value="P:negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000813">
        <property type="entry name" value="Vesicle-associated protein 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF6">
        <property type="entry name" value="AT11025P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019693">
        <property type="entry name" value="VAMP-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="9">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5474979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="285" mass="30899" checksum="652E90038F528A5A" modified="2023-11-08" version="1">MSLELDPPELGFKRPFTQEVCEVLHLQNPTPVPVVFKVKTTAPKHYCVRPNSGRIEPGKQVDVQVLLQAMKDEPPLEQKCKDKFLVQSVAVPGDDIDQSNVTAVFEKVSKSAINERKIRVNWLQADAGQTSPQPAAPQSLDDEPPAYNSPGVNNYETPAVGLAKKSHVEQSSPIPAPDFSEKAIKNEPSPPAEFNTAFSNTREAVASALPSGEDLKSQLADANAQIQRLKDRLADQGLRQRKTGGEAPAAPATMQQTHGSAESGVSVQMVAGLCLLSFLIAYFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTA7</accession>
    <name>A0A9W9WTA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786858.1">
        <property type="nucleotide sequence ID" value="XM_056937766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTA7"/>
    <dbReference type="GeneID" id="81628016"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="188" mass="20225" checksum="08EF33A56CF67E26" modified="2023-11-08" version="1">MITSNPSQPSNPYWVSSIKSSTTYHLPSTPIQHPQNHHNMKSPNSNPPPASQPRSSPSASPSSSPSLAQTLTSLSTPLTPLVHILTGIPHPEFPSCILSFHLLTSPQLDRLAVYYHQVWPPTPQTGLYPVVMRAWVGWVYGDGEGEADIGIEEKRKRFGWFIGLYEAKGICLGGGTRGEGGGGGCDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTD3</accession>
    <name>A0A9W9WTD3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786934.1">
        <property type="nucleotide sequence ID" value="XM_056937842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTD3"/>
    <dbReference type="GeneID" id="81628092"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5475176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="134" mass="15097" checksum="7F71692073460048" modified="2023-11-08" version="1">MTKIIPIDRYGDTDEVLRTLSVLDKKYKGWTTAAAAADEQPVQRCIDTHHDIVHNMPSKDSPMDDLTVCALRSIMPKTEVHSWRRDVEKNNGWIRGTRVPKGKGVVVEAFGIRWIVVVGDKTVLTGESLQLKFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTU7</accession>
    <name>A0A9W9WTU7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_008434</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787126.1">
        <property type="nucleotide sequence ID" value="XM_056938034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTU7"/>
    <dbReference type="GeneID" id="81628284"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="41"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5475368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="522" mass="57136" checksum="F6B892157F3C5A3C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTY8</accession>
    <name>A0A9W9WTY8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(9)-N1)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA methyltransferase 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1G9)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_007778</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787244.1">
        <property type="nucleotide sequence ID" value="XM_056937379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTY8"/>
    <dbReference type="GeneID" id="81627628"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="10">
        <location>
            <begin position="364"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="604"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5475491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="644" mass="70861" checksum="D3DA72367DB8E1BC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU94</accession>
    <name>A0A9W9WU94_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="11">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Lipoate synthase</fullName>
            <shortName evidence="11">LS</shortName>
            <shortName evidence="11">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_007881</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="11"/>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787347.1">
        <property type="nucleotide sequence ID" value="XM_056937482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WU94"/>
    <dbReference type="GeneID" id="81627731"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 11" id="KW-0408">Iron</keyword>
    <keyword evidence="8 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="130"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5475594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="400" mass="43701" checksum="D31D2E218A5C2BB3" modified="2023-11-08" version="1">MAASSRALRCLSSVRTASPSLGPSALPIAYRTYATTDASSATSSSPDGLTRRRATTFKDKLNAGPSFSDFVSGGKEEPLDAAEAYELKTAMTPIPDSKNYQRLKKDLRGLNLHTVCEEARCPNISDCWGGSDKSAATATIMLMGDTCTRGCRFCSVKTSRSPAPLDPHEPENTAEAISRWGLGYVVLTSVDRDDLADGGARHFAETVIKIKQKAPNILVECLTGDYWGNMDMVALVAQSGLDVYAHNVETVEALTPHIRDRRATFQQSIQVLDAAKQARPDLITKTSLMLGFGETDEQIEDALRQLRAVKVDVVTFGQYMRPSKRHMAVHEYVTPDRFEYWRKRALEMGFLYCASGPLVRSSYKAGEAFIENVLKKRRAASGGVTPAVEQTSPSLDKTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUJ7</accession>
    <name>A0A9W9WUJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_007144</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787544.1">
        <property type="nucleotide sequence ID" value="XM_056936745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUJ7"/>
    <dbReference type="GeneID" id="81626994"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000223">
        <property type="entry name" value="Major facilitator superfamily domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF31">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="11"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5477000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="453" mass="47838" checksum="7226B6387D67C383" modified="2023-11-08" version="1">MAIAGAQRKQVLKVLMISLLLDLISFTFILPLFPSLLSFYRAQDPSPDSLLNRIFHYLNAYKNAFARPIDSRYDIVLLGGALGSLFSLLQAFAAPVIGRLSDRHGRRRALLTAMVGNICSVALWVSARDFRTFLASRVVGGLSEANVQLANAIVADVTDETRRGASMALVGACFSIAFTFGPMMGAALSTVDIVAANPFMTAALVSLVLVVLETTYLWACLPETHPRLTTLQQEGSTGSNKAEASNKHPASQAGLAKSAAHQHTNRPALLNAIHFLFLLPFSGLEFSLPFLTATLYAGTSTASPAALNGRLLSLMGLIASLLQGTVVRRLPPLVTVRAGVVACALSFFCLAHVSSPSGLYAAGGLLAITSATVVTGLNSLGSLEAREADRGAVMGRLRGWGQAGRAAGPILFCSLFWWAGREAAYTVGGMAMSGVALVVFALLKSPSLQVKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUL3</accession>
    <name>A0A9W9WUL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Arsenical-resistance protein Acr3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_007174</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787574.1">
        <property type="nucleotide sequence ID" value="XM_056936775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUL3"/>
    <dbReference type="GeneID" id="81627024"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015104">
        <property type="term" value="F:antimonite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000009">
        <property type="entry name" value="Arsenite transporter, ACR3 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057:SF1">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="ARSENITE EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5477030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="382" mass="41816" checksum="4BA6947E009CEF3B" modified="2023-11-08" version="1">MADLEANKETVNLHNRNRPDVNPSEQDGPVSDPDRCIDTSGSIEENKHLSIFHQLGLLDRFLAVWIFLAMLIGILLGNFVPSTGPALQKGNFVGVSVPIAVGLLVMTYPILCKVRYESLHRTLRQKALWVQIEFSLIVNWIIAPLFMLALAWAFLPDEKGLREGLILVGIARCIAMVLIWTGLAGGDTEYCAILVAINSVLQMVLFAPLAIFFIRVMSGDQIHLQYSLAARSVGVFLGIPLGAAIVTRFGLRSLVGEQWYERKFLNWISPLSLIGLLFTIVVLFASQGRHVVHQIVSVVRVAAPLVVYFAVIFLATLLVTRRCGFGYELSCTQSFTAASNNFELAIAVAIATFGVDSDQALAATVGPLVEVPVLLGLVYVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVJ0</accession>
    <name>A0A9W9WVJ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_007461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787861.1">
        <property type="nucleotide sequence ID" value="XM_056937062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVJ0"/>
    <dbReference type="GeneID" id="81627311"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5 7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="6">
        <location>
            <begin position="80"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5477317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="404" mass="45150" checksum="8F247FC157D27971" modified="2023-11-08" version="1">MLFRVAARQAAPLRRQAFAPLTRRSVTTDAASAHAENIPQEDDKPFTVRLSDESFETYELDPPPYTLETTKKELKQMYHDMVSMRRMEMAADRLYKEKKIRGFCHLSTGQEAVAVGIEHAINRDDKVITAYRCHGFALMRGATVKSIIGELLGRREGIAYGKGGSMHMFAPNFYGGNGIVGAQVPVGAGLAFAQQYNEQPNTSIVLYGDGASNQGQVFEAFNMAKLWNLPVLFGCENNKYGMGTSAARSSALTEYYKRGQYIPGLKVNGMDVLATKAAVQYGKDYAVSGKGPLVFEYVTYRYGGHSMSDPGTTYRSREEIQRMRSTNDPIAGLKQKMLEWGVTSEEELKELDKAARAYVDAEVAEAEKMAVPEANPRILFEDIYVRGSEPRWMRGRTVDETFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVK9</accession>
    <name>A0A9W9WVK9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_007491</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="10"/>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787891.1">
        <property type="nucleotide sequence ID" value="XM_056937092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVK9"/>
    <dbReference type="GeneID" id="81627341"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000092">
        <property type="entry name" value="Glycogenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="250"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="375"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="604"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5477347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="732" mass="81918" checksum="3422B6CC1A1FF7F9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVS3</accession>
    <name>A0A9W9WVS3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_007574</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787974.1">
        <property type="nucleotide sequence ID" value="XM_056937175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVS3"/>
    <dbReference type="GeneID" id="81627424"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF6">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040961686" description="Mid2 domain-containing protein" evidence="7">
        <location>
            <begin position="30"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5477430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="31459" checksum="B49F78EED475B104" modified="2023-11-08" version="1">MLLRPRSQGPSSLWWSSVTAMLFAPLIVAQCYYPNGTLETDESYQPCPGFDGKARMCCATNRKNPFGGAEANGFTANKCLPNGLCVDGSTRTDPSGQVILIQNYWRDMCTSQDWTQEGCLNVCTNALGNTTTRITPCDNTNSSRTWCCGDTQDCCNGPDAIYIAATLPGYVANMTSPGTSTTAPTSTGTANPATTTASSTTGSSTGSTTSSSSSFSSSGLSTGAKAGIGIGVALGAIAILAGLAFLLMKRRRRNARFAALEKDAHFAPALRPSELSAGDSRSEVPASPHSLAQELPGSSTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVW9</accession>
    <name>A0A9W9WVW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788056.1">
        <property type="nucleotide sequence ID" value="XM_056937257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVW9"/>
    <dbReference type="GeneID" id="81627506"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000043">
        <property type="entry name" value="General stress response phosphoprotein phosphatase Psr1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="336"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5477512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="510" mass="54997" checksum="B39CC63B27809C5F" modified="2023-11-08" version="1">MPAPNVAETPAANDRATSQPASSSSAPTSSTPAMAAADAPTKKNRLHLPLPSRRSSKTDQQSASEKAAEATQDDPSRRGSRVSMLNLARERSRASSRRSRRTQQDATTVDKSPETAQPTSSGTNSPSKPLQKKGSKLFSFLSCCTSPEVDGDDNAVPPKKTSKQAVASNRLPATDKTETPAGDSSTAVSKEPTDFGDEKAAALAGDQSRSREAEPSASTLTGPQADGTSGDVLTTGVPNDGSQRHEESAFATNGVAPEPREGMAKVDEEDSSSHIPTTAERAPKAVAGETDETPSQAEEVSQSVTVLPPPPPPPVPEVAAERGQQQQWLLPPALPHLANRKCLVLDLDETLVHSSFKVLERADFTIPVEIEGQYHNIYVIKRPGVDQFMKRVGELYEVVVFTASVSKYGDPLLDQLDIHNVIHHRLFRESCYNHQGNYVKDLSQVGRDLRETIIIDNSPTSYIFHPQHAIPISSWFSDAHDNELLDLIPVLEDLAQAEVQDVSMVLDITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1V9</accession>
    <name>A0A9W9X1V9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cystathionine beta-lyase</fullName>
            <ecNumber evidence="3">4.4.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cysteine-S-conjugate beta-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_006764</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L,L-cystathionine + H2O = L-homocysteine + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13965"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18121"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29256"/>
            <dbReference type="ChEBI" id="CHEBI:58717"/>
            <dbReference type="EC" id="4.4.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.13" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788300.1">
        <property type="nucleotide sequence ID" value="XM_056936365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1V9"/>
    <dbReference type="GeneID" id="81626614"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000013">
        <property type="entry name" value="Cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006238">
        <property type="entry name" value="Cys_b_lyase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01329">
        <property type="entry name" value="cysta_beta_ly_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 13 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5480870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="442" mass="47330" checksum="820100CFAD5C1981" modified="2023-11-08" version="1">MSASGSGAAHGASESASAAKKSLPRVDLHGNDLPPSPAPSSPHPGRRYNIATELVFTEGNDQYNASSVPIYQSATFKQTSGSGGGEYDYTRSGNPTRTHLERHLAKIMSAQRALVVSSGMAALDVITRLLRPGDEVVTGDDLYGGSHRLLKYLSTNGGIIVHHVDTTNPEKVLGVLNSKTAMVLLETPTNPLIKIVDIPQIATAAHEANPNCLVSVDNTMMSPLLLNPLELGADIVYESGTKYLSGHHDLMAGVIAVNDLALGERLYFPINASGCGLSPFDSWLLLRGVKTLKVRMDQQQSNAQQIAEFLESHGFKVRYPGLRSHPQYELHNSMARGAGAVLSFETGDVNVSERIVESAKIWAISVSFGCVNSLISMPCRMSHASIDAKTRAERAMPEDLIRLCVGIEDVDDLIEDLQRALVEAGAVKVTLDGIHAASVESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1Y0</accession>
    <name>A0A9W9X1Y0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine-threonine rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788314.1">
        <property type="nucleotide sequence ID" value="XM_056936379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1Y0"/>
    <dbReference type="GeneID" id="81626628"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5480884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="68226" checksum="3A5D7F03C1C07C1C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X267</accession>
    <name>A0A9W9X267_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_006676</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788212.1">
        <property type="nucleotide sequence ID" value="XM_056936277.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81626526"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18025">
        <property type="entry name" value="DEXHc_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001039">
        <property type="entry name" value="ATP-dependent RNA helicase DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055124">
        <property type="entry name" value="PIN-like_DDX60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059032">
        <property type="entry name" value="WHD_DDX60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23002">
        <property type="entry name" value="PIN-like_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26076">
        <property type="entry name" value="WHD_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="839"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1296"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="471"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="531"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="607"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1153"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1250"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1792"/>
            <end position="1880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="617"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="643"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1253"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1264"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1826"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1866"/>
            <end position="1878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5480782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1907" mass="214241" checksum="B91DC658DB9A2095" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2J9</accession>
    <name>A0A9W9X2J9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_006791</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788327.1">
        <property type="nucleotide sequence ID" value="XM_056936392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2J9"/>
    <dbReference type="GeneID" id="81626641"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5480897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="139" mass="16039" checksum="E92FFABB8B66A095" modified="2023-11-08" version="1">MTRGFATIKPECQEQFDTLKETKTLDYIVFVPDWHKKEISVAKSGKSDNHDEIVSFLTTDAPRYMVTKFTYDGPTGDEKRHKLVFITWVPEGANSHDKTYCLHNKDHLYRSLDDLSLHVQASKPEDLAHATILKQFKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2P4</accession>
    <name>A0A9W9X2P4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_007044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788580.1">
        <property type="nucleotide sequence ID" value="XM_056936645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2P4"/>
    <dbReference type="GeneID" id="81626894"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5481150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="203" mass="22420" checksum="631AA8238194FA1C" modified="2023-11-08" version="1">MYAHLIRGSDVKVIMGGGRKVQDVRRFTPQDTCHEIVPFTVNPWGDVRPMMEGMHGNNQRGSRGFPFAAEECGELHDGAAVGSRWDAEALWEKTSHLRSVIGSATDDYCLHRPKRFSVRTEAALAGFKMHCNGNGSTENRSPGRGTETFLPIRVNVDSCSEKSVTFLLERHRDVEVPMMIADVAEYALTVERLGHRGGLGPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2P8</accession>
    <name>A0A9W9X2P8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_006192</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788718.1">
        <property type="nucleotide sequence ID" value="XM_056935794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2P8"/>
    <dbReference type="GeneID" id="81626043"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04041">
        <property type="entry name" value="C2A_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057349">
        <property type="entry name" value="C2_Mug190_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037767">
        <property type="entry name" value="C2A_Mug190-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25331">
        <property type="entry name" value="C2_Mug190_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="260"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="485"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="674"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="646"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1079"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1127"/>
            <end position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5482746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1245" mass="138906" checksum="701145BA1AEB4E99" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2T8</accession>
    <name>A0A9W9X2T8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="16">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">N7539_006284</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="16">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Associates in the nucleolus with the 60S and pre-60S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="16"/>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788810.1">
        <property type="nucleotide sequence ID" value="XM_056935886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2T8"/>
    <dbReference type="GeneID" id="81626135"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17942">
        <property type="entry name" value="DEADc_DDX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000379">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000460">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044773">
        <property type="entry name" value="DDX18/Has1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="164"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="354"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="581"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ5482838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="616" mass="68785" checksum="BF3680C8FEE7343E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2U4</accession>
    <name>A0A9W9X2U4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788196.1">
        <property type="nucleotide sequence ID" value="XM_056936261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2U4"/>
    <dbReference type="GeneID" id="81626510"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5480766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="320" mass="34970" checksum="31566DF107A74A14" modified="2023-11-08" version="1">MDTITVTGNLLHIFSRKERAKRKRQSHEPEHLGLLPVSAHPGPRSTHPRPLSSFAPAPTSHPQSRRGHGGFLYELGLGVGDGVGVRVGQGGSGGYSASSQARQASSSSSTSTSNSNSTGTASQQYYYARERRSGPHQQEYHHQHPYHHHEHHNAMPPPQQSYPPSRASVDLSGGYPALPTYDPSKYPPIQPSFTDSTVDSFAWHHHLPGQSSRLSEVHYHDARPSSMYFQPPRVPNLCAAPPLPQLQPPSQPQSRAVRNQPTVASSHHPNMGSTEHHRSSRPGDGRERSFSEPMPAAAAGQSSRGPRRAKPVLSRLITNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3B0</accession>
    <name>A0A9W9X3B0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_006507</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a zinc transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789033.1">
        <property type="nucleotide sequence ID" value="XM_056936109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X3B0"/>
    <dbReference type="GeneID" id="81626358"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000014">
        <property type="entry name" value="Cation efflux protein/ zinc transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="644"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="722"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="11">
        <location>
            <begin position="543"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="790"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="791"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="816"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5483061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="899" mass="97713" checksum="5BB2A9D66CAA0927" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3G4</accession>
    <name>A0A9W9X3G4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788526.1">
        <property type="nucleotide sequence ID" value="XM_056936591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X3G4"/>
    <dbReference type="GeneID" id="81626840"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000812">
        <property type="term" value="P:regulation of barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5481096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="359" mass="39518" checksum="594B33BDC3CC4DBF" modified="2023-11-08" version="1">MASQDQLEQQIIIQARQRQLLRQQQGLAAQAMAQEAQRRAGRSQPRTMRMSTHFDDLPIVEAGDVELLIPEPACTSPFDLACRDGPLSTVIEGLTYQPRTPAFLHRGLLIAMRSGNLETAQYLLTHGAPISRHTPELVLRSPPQRKIELFELFLQHGWTPNSPGLYGAVILPSIVEDLPLLSWFLAHGANPNLGPQQLWHDRLGPSETKTCLALEIASARGSFEAVKMLLEAGARIDYGTPLHSAAGVCPKGTNPHAGRVTPSKEFDNDRIPVMRLLVEQGADVNQKAESRHITPQYAIVHAVMAGAFERVKWLLAHGADAHLKGSFGSAIEYASFWGPEMRQVIEEGLAARNESTAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X4R2</accession>
    <name>A0A9W9X4R2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CBM6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_006042</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000007">
        <property type="protein sequence ID" value="KAJ5483842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789112.1">
        <property type="nucleotide sequence ID" value="XM_056935644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X4R2"/>
    <dbReference type="GeneID" id="81625893"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04084">
        <property type="entry name" value="CBM6_xylanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18618">
        <property type="entry name" value="GH43_Xsa43E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CBM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052176">
        <property type="entry name" value="Glycosyl_Hydrlase_43_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040818699" description="CBM6 domain-containing protein" evidence="9">
        <location>
            <begin position="27"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="10">
        <location>
            <begin position="327"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="7">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5483842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="452" mass="49440" checksum="1AC09DB0530A6220" modified="2023-11-08" version="1">MLSKQQFWPWACTLLSLSTFGNVAKADNPIVQDIYTADPAPVVYNDRIYVFTGHDNNGATFYDMTDWRLISSADAVNWQHHGSPMSLTTFKWANANAWAGQVIERNGKFYYYAPVRHSTGAMAIGVAVSNSITGPYTDALGKPLVENNEIDPTVWIDDNGQAYLYWGNPGLYYVKLNADMISYSGGVNQVSLTTAGFGTRTGNAQRPTTFEEGPWLYKRNGLYYMIYAADCCSEDIRYSTGPTATGPWTYRGVIMPSQGRSFTNHPGIIDFKGNSYFFYHNGALPGGGGYARSVAVESFTYRSDGTIPQIDMTTNGPAQIGTLNPYVRQEAETIAWSSGIQIETCSEGGYSVGYIKSGSYIKVKGVNFGNGAKTFTARVASAGNGGDIQVRLDSQSGSIVATCTVRNTGGWQSWASVSCPVSNANGVHDVYFVYSSSDKNSYLFNVNWWQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X548</accession>
    <name>A0A9W9X548_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789322.1">
        <property type="nucleotide sequence ID" value="XM_056935450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X548"/>
    <dbReference type="GeneID" id="81625699"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07600">
        <property type="entry name" value="BAR_Gvp36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018859">
        <property type="entry name" value="BAR_dom-cont"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10455">
        <property type="entry name" value="BAR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="2">
        <location>
            <begin position="14"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5484052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="305" mass="33709" checksum="24BA8ACC7FAAB3B1" modified="2023-11-08" version="1">MDRVQAFGKTFSASFTPFAQRTQQLIKEQLGQVEDKTQLPDEYIDLEKRVDALKLVHQKLLQVTSQYSNEAYDYPPNIRESFNDLGRTINEKVNLLAQASSPAEAQAALTAPPSAKPQPKTFNHAIARASLAGSQTLSQNSHGDDPLATALEKYALAEERVGEARLAQDAQIQSRFLAGWNTTLNTNLMFAAKARKNVENARLTLDSIKASKKAAAHGDLDNLSEDARQEIEQAEDEFVAQTEEAVSVMKNVLDTPEPLRNLADLIAAQLEFHKKAYEILSELAPTVDALQVEQEASYRKSREGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X584</accession>
    <name>A0A9W9X584_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789334.1">
        <property type="nucleotide sequence ID" value="XM_056935462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X584"/>
    <dbReference type="GeneID" id="81625711"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5484064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="113" mass="12557" checksum="8EA103E3B7BD9367" modified="2023-11-08" version="1">MSSNLVRPKGSSEKGGVVALSAIESFGQFTATLKLPWTPGQSVNSPHNVVCGKTIRLQRRWLENGQPEIFWLDDAENTGVRLRARQSRGAGSERSRERDDDCWEVDVEGQSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5H5</accession>
    <name>A0A9W9X5H5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_005821</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789295.1">
        <property type="nucleotide sequence ID" value="XM_056935423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5H5"/>
    <dbReference type="GeneID" id="81625672"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="17"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="230"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="273"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5484025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="393" mass="44286" checksum="31D8AE78FABF64B5" modified="2023-11-08" version="1">MGPDEDSDVGDEFTELDAGHRDAVAVSKFNFYGNRLLTASADHRMKVWDLKDGQWQCIDTWRAHDAEIRDATWNGPFTGQHIASVGEDMRLKIWQEDPSQAPGSGRRFRSIFRLTAPNRHPFVSLDFRNIDLESWLAVITRDGYLMVFEPVTPDNLADWQAIDQFRVCTQPERGEETSFKIQFHHGPSDITHTVLPKSDRKSLSLVVAAMNTVKIYRTDANRRFYHAIELTGHSSLVRDVSWARGSVRGYDLIASGGRDGLIRIFEVYTKNAAQAPQPTNSRKAEQREQQPSTTQSTSQSTSQSTSQSGIGTALANRTPKSNTSRQATGDPQFRHSFKEVARLDSKHVDVWQVEFSFAGDCLMSCGDDGTTRFWKKGLTGEWLEFAETDMTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5K6</accession>
    <name>A0A9W9X5K6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_004836</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789632.1">
        <property type="nucleotide sequence ID" value="XM_056934438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5K6"/>
    <dbReference type="GeneID" id="81624687"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF8">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_6G00670)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cupredoxins"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040848672" description="Extracellular serine-rich protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
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            <end position="208"/>
        </location>
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            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5484848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="37295" checksum="7CFF8C13E5A314FB" modified="2023-11-08" version="1">MLAKILQALGLGILAGSGFTHVLAQASTTTESTITPVPAAASVTLTGSVTHTVQVGPKASPHAYVPQSLTAQPGDVVVFEFYPTNHSVVKADFGAPCVPATDGVFFSGIFDSFSLRDGQIVGPPPTWSLVINDTQPLFYYCTAISSCLGNGMVGVINPNSTQTFEAQYDKALKYPYMLVPGQSMPAEGSGSLSTSSTQNPSSDTATSAANKGLSGGAIAGIVVAAVVFVAILVILFFVLGRNRVYSQWMSSPDGRTERTARWAMGSNYGGQKSEAESVSTKAPGTEVNSVVCGDHPMRHFSPGPESKVTAGHATTWHHYYPPSYSSEGQPASFGARGPSELEGAGVAHQLPERRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5P9</accession>
    <name>A0A9W9X5P9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789453.1">
        <property type="nucleotide sequence ID" value="XM_056935581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5P9"/>
    <dbReference type="GeneID" id="81625830"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42106:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42106">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5484183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="653" mass="68611" checksum="1CE93A7876525C9C" modified="2023-11-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5X9</accession>
    <name>A0A9W9X5X9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Camp independent regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIT1/WOR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789758.1">
        <property type="nucleotide sequence ID" value="XM_056934564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5X9"/>
    <dbReference type="GeneID" id="81624813"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5484974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="52672" checksum="21D571D7819D7317" modified="2023-11-08" version="1">MVNGTAAVLEPTFTGYVATTQDALILFEACLTGVLHHVPRRPHDRERSHLVRSGSVFIYEENSSGIKRWTDGVTWSPSRILGNFLVYRELEKPFPPGEKKRAMKKANRRPTPATRPGEPYPRPESTGTGYSPTSPPGSFSDNRAPNQSEVERALVGSLVDSYGFKESGLVKKTMSVTVMGITHHLVSYYSVEDVMRGVLNPPSMVDSLRYIRPRVELTQKQNFRAPVDDMETSAMENPHDPSHAALYGYRPQPLMPPPGAFGMPNPSSDFYMHPGPYATAHASHAPPHPPYSMAGSIPGQSAPNPYLPSPAAMAANPIAMGSKNDDYHAFRAGPYGGSMDSVSHSALSSSIPGMNTGLASSYSDRTRSTSDHSPSAYRNSSISSRSVATDATSPLDPSTPGTYSRSSFSIPGHLDGSNSSTPIDSRGIGPLDPNVPRRDSNPVHPSYYTPDRSQYYVHATAPVNHPHYATAQPLASWGTTAPAQPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X647</accession>
    <name>A0A9W9X647_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">37S ribosomal protein SWS2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_005048</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789844.1">
        <property type="nucleotide sequence ID" value="XM_056934650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X647"/>
    <dbReference type="GeneID" id="81624899"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000015">
        <property type="entry name" value="30S ribosomal protein-like protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5485060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="119" mass="13678" checksum="96A0C40C60F423E1" modified="2023-11-08" version="1">MVFILGVNFPERNLLKKSLESFFGIGGHTSSRLLARFNIHPTCRVGELANKQVLDLTAVLSDMKIENDLRREVLNDIKRLKETGTYRGRRHALGLPVRGQHTRTQIKTAVKLNRMERRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X676</accession>
    <name>A0A9W9X676_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789219.1">
        <property type="nucleotide sequence ID" value="XM_056935347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X676"/>
    <dbReference type="GeneID" id="81625596"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5483949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="55591" checksum="2C2286EDFD750E1F" modified="2023-11-08" version="1">MTQSDQIDTLASALVARFLRTNAFTDTLRAFIREAGLPPGVGQTSGDDTHNMTIQSLLVEKRAYDETVNFERLGNGNQEIVSWRTPAPCKPIVIATPTSANLLAASIELWQDPRWSEETSGDSGHVSSNGARPLLISTGADRQMHLLDIEPENKHVTSFSGLSDSPVLSFVPILHGRFILMTNMSGHLLLQRGSEIACSRKDHAKYAVKVVVHEEIDHSSASTILWIATAGWDATVFLYRVVIRPEDGDATPNIRDPVARINLASNPESLLFVRHVDSGELLLLVSRRDSSYIHYYQVQPTPEPSSQSSQNDSNQSSTPKGTTECRLLGKQNLAPHSNAWVAFSPSHMALSPLDPGLLAVATSSEPHMKVIIVRLLFPSAPSSGNATSSTTEAAVTQASQALEALALQNREDAAILIQANTFAPQTSYSTPQVAWRPDGSGVWVNGDDGVVRGIEIKTGKVVATLKQGHEPGFKVRTIWAGFVDVPGETGRKREEWLVSGGFDKKLIIWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6K1</accession>
    <name>A0A9W9X6K1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_005925</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_056935527.1"/>
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    <dbReference type="GO" id="GO:0005663">
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:DNA clamp loader activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:DNA repair"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="BRCT_dom"/>
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        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
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        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="RFC1"/>
    </dbReference>
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        <property type="entry name" value="RFC_lid"/>
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        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="13">
        <location>
            <begin position="306"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1003"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="396"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
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        <location>
            <begin position="147"/>
            <end position="160"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="180"/>
            <end position="191"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="270"/>
            <end position="279"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="958"/>
            <end position="968"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="969"/>
            <end position="989"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1003"/>
            <end position="1017"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1022"/>
            <end position="1031"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1035"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5484129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1046" mass="115985" checksum="197530812815B5D4" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6V0</accession>
    <name>A0A9W9X6V0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cell pattern formation-associated protein STUA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2 10">Cell pattern formation-associated protein stuA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Stunted protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_005365</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFG1/PHD1/stuA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
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        <property type="nucleotide sequence ID" value="XM_056934967.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000003">
        <property type="entry name" value="Ascospore maturation 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029790">
        <property type="entry name" value="EFG1/Phd1/StuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792:SF1">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0183">Conidiation</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="12">
        <location>
            <begin position="256"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="16"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="121"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="185"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="374"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="511"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="580"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="690"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5485377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="764" mass="81743" checksum="1935FD78DC81EC49" modified="2023-11-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X795</accession>
    <name>A0A9W9X795_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Decarboxylase NovR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790371.1">
        <property type="nucleotide sequence ID" value="XM_056935177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X795"/>
    <dbReference type="GeneID" id="81625426"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF41">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G01330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="53"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="290" mass="31415" checksum="E0D1B3BAF4166649" modified="2023-11-08" version="1">MAPPTATETVNNITMQAPESSQVAGVEKAKVKMQMPGMPKFDDKYKEREFRKGRLAAAFRIFGKYGFDEGVAGHITLRDPVDPSTFWVNPFGTAFSLIKASDLIQVDHSGTVIDGGPNRMLNAAAFMIHSAIHAARPDVLCAAHSHSLYGRAFCSLGRPLDIISQDSCAFYNDHVVYEQFNGVVLAEEEGKKIASALGTKKAALLQNHGLLTVGKSIEETIFWFVSLEKCCHAQLLADAAASGRGGQTVKIDDADAAFTYQTVGTPLAGWFSAKPLFDVIHKETGGEYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7X2</accession>
    <name>A0A9W9X7X2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_005308</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790104.1">
        <property type="nucleotide sequence ID" value="XM_056934910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X7X2"/>
    <dbReference type="GeneID" id="81625159"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030586">
        <property type="term" value="F:[methionine synthase] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000027">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000007">
        <property type="entry name" value="Methionine synthase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF84">
        <property type="entry name" value="METHIONINE SYNTHASE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="214"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5485320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="632" mass="69415" checksum="4B01E4A065A57D96" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCG0</accession>
    <name>A0A9W9XCG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
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    </dbReference>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="660"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="732"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="794"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="842"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1068" mass="114221" checksum="DFD3E25DC4A7B00B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE89</accession>
    <name>A0A9W9XE89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_004655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791798.1">
        <property type="nucleotide sequence ID" value="XM_056934257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XE89"/>
    <dbReference type="GeneID" id="81624506"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
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        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5489765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="143" mass="15990" checksum="3C3234EE34ABFA59" modified="2023-11-08" version="1">MPTLTGSCYCRKIEYELRLNSIDDARTTLCHCQNCKKAFGTNYGLTAKVSKDAFHLTKGQPKEHAADNGSGVSIYRHFCDICGSFILEFGENAKQQFRYICVGSLDDPEALPPKGEFFCKSRASWMPEIPGESQCWMLGAVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEF4</accession>
    <name>A0A9W9XEF4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_004418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056934020.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81624269"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF12">
        <property type="entry name" value="PARAOXONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5489528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="340" mass="37273" checksum="99CA4E1DBB4E959A" modified="2023-11-08" version="1">MASVLLAPFKPLTLRIKVLGTLTATRLTSRNFKGPFNTHGIDIYTPPEDPSSIYIVAVNHLPNPAFYASATRPNPAQIPQARSRLEIFHHKLGSTEATHLRSIWHPLIRTPNDVYFHTLHEIYVTNDHFYRDGVMRLIEDLAYGKTAPTDLIHLKITDPFTQTLKSGGDVDDTAGVVGTLANKGIHNNNGLGHGKTPSEIMIGRHRHRPASPGRSRPAAIQLPCTLDNPSYFADPYVAKTGRDASGYVLASLAQAIAFPNGLDLVMVMLVQPRGDTNSKDKSKDHWTQKVIFQDDGHILRTASTAVLVAIDPDMNKGKKQANLFVTGPLGHGVVVSRIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEL2</accession>
    <name>A0A9W9XEL2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_002373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791935.1">
        <property type="nucleotide sequence ID" value="XM_056931976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEL2"/>
    <dbReference type="GeneID" id="81622225"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="9"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="512"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="599"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="677"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="620"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="694"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="743"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5490806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="792" mass="88097" checksum="223C5132E5909234" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFD3</accession>
    <name>A0A9W9XFD3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannan endo-1,6-alpha-mannosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792369.1">
        <property type="nucleotide sequence ID" value="XM_056932410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFD3"/>
    <dbReference type="GeneID" id="81622659"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF1">
        <property type="entry name" value="ENDO MANNANASE, GH76 FAMILY (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040859391" description="Mannan endo-1,6-alpha-mannosidase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="40774" checksum="6979F09CBEEEE697" modified="2023-11-08" version="1">MYSLPWIRLGIVFLGCLHFKSAIASDELARAQIALNTLQTWYNTTSGLWDTCGWWNGANCMTVIADMAQVDSSVGDLATGVFQNTLAQAPVYNPNPGPENRTQARVTDGVNAVNWLDSAYDDDGWWALAWVAAYDVTKDSTYLTLAQGIFANLAKVWGTRCGNGGIYWSTTSSYVNAITNELFLSVAAHLANRASSDVEKENYVQWAQKQWTWFSTQDFFGPDYTINDGLLGNCQNNKQTVWSYNQGVILGGLVELNRAAPNQTYLDWANRIAQAAINKLADANSVIHDVCEPNCAPDGTQFKGIFIRNLKSLQMASPNAVYQRVITSCADSIWTNDRNPDNELGVNWAGPVASVDASTHSSALDALVAAIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFV9</accession>
    <name>A0A9W9XFV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_002404</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791966.1">
        <property type="nucleotide sequence ID" value="XM_056932007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFV9"/>
    <dbReference type="GeneID" id="81622256"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF26">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_4G05870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5490837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="325" mass="35567" checksum="DB24D765D1F80297" modified="2023-11-08" version="1">MHKSTERGAEGPQDQFKSGHKVPIQHHEKPGLQSELGDPKPTSTKLPTEDNGYQTYRAAGKLEGKRAVITGGDSGIGRAIAILFAMEGADVLITYLPQEESDAQDTKRRVEETGRKAHLLAVDLRDKKNCQKVVDTALETMGGIDTLVNNHGYQNMVEDIKDLDEDQWERTFDTNIHPFYYLSKYALPHMKQGSTIINCASINAYIGRPDLLDYTSTKGAIVAFTRGLSNQQIKNGIRVNCVCPGPTKRNAVTILNRLPRFSLPVWTPLIPATMNSSAQDQFTSPMGRPGQPSEVATCFVFLASPDSSFISGQSLHPNGGVVVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFX6</accession>
    <name>A0A9W9XFX6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_003066</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the COA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792628.1">
        <property type="nucleotide sequence ID" value="XM_056932669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFX6"/>
    <dbReference type="GeneID" id="81622918"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="10">
        <location>
            <begin position="82"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5491499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="137" mass="15373" checksum="97F31CE086F429F2" modified="2023-11-08" version="1">MERMYSNAKTHGHLGRTSNDCRLLQHLTFRPPLQHTATDHGKRNVRAMIGIKPFAGLTDTLVLLNSFNSTYYGKDYRAGAALLRARRPYLVKNAVTGFGLFAFAIAVYSYTIRAVGQEDFSDVKVPDTPVKKLPEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG01</accession>
    <name>A0A9W9XG01_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792699.1">
        <property type="nucleotide sequence ID" value="XM_056932740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG01"/>
    <dbReference type="GeneID" id="81622989"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="93" mass="11110" checksum="267FB72390452F0B" modified="2023-11-08" version="1">MARSRRQARSESYNDNPRTREDSSNDSSDEYSKDNNSLRNLIIHYADTRIFLKYYLDRRINKNLPTIIRGLDPDNNIIYIAYRISRTINPDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG65</accession>
    <name>A0A9W9XG65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-serine dehydratase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_002735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DSD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792297.1">
        <property type="nucleotide sequence ID" value="XM_056932338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG65"/>
    <dbReference type="GeneID" id="81622587"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="3">
        <location>
            <begin position="322"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5491168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="464" mass="50913" checksum="34B4B5BF62B17097" modified="2023-11-08" version="1">MEPLVLPSQQQLREHWVGKDLEEIPKPAVVLDRAIIRRHCARMKRTVETLGVGFRAHVKTHKALQIAEMQMDNGDPEAKFIASTLLEIEMLHPLLKSLKDAEKSVNVLYGIPLVPSHISRLATLAADIGEGSVSAMIDHPDQVPYLKHFFEVARFPVCVFVKVDTGYHRAGLPPISLNKNGLLERLAKAEADGWVRFLGLYSHSSLSYTAKSPAEAMSHLIGEIQGCKDALGRWLSLLPTDRELVISVGATPQISSSHNLVGEGTEYPEAQKLKALLDNPCLENNDVKVKIELHAGNYPILDMQQVSTNAREGAGRFEDEIAISVVAEVCSVYNDGERDKSEALVAAGTLALGREPCANHSGWGVLSSWRVGAECTTTRIVVDRISQEHGIVAWGSGMEGKSVPLNLGQNVRIFPNHACVAAAFFGWYFVVDSDEDQDGSRVVDIWVRGRGSGVSDPFLMTRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG81</accession>
    <name>A0A9W9XG81_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792327.1">
        <property type="nucleotide sequence ID" value="XM_056932368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG81"/>
    <dbReference type="GeneID" id="81622617"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="109"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5491198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="211" mass="22945" checksum="24611D603B167EE9" modified="2023-11-08" version="1">MTTDDPTVFNSIPWVSALLHDKSFVTYTIPSRTVKPSTEDNLFSKTLNTSTTFSACLSQYRRPSGLGTEPSTTDFEPNTDTHPSSSPSSPITELRMFFMLGSDLNGYPGILHGGIAATLLDECTGLLLALNGQVGDAVTRQEPGSRPGPVTAYLNTRFLRPVPTPGVVMVQARMVEGEGDRKWRIEGRLVDGEGLALVEAEALYVRPRSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH14</accession>
    <name>A0A9W9XH14_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_001592</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793226.1">
        <property type="nucleotide sequence ID" value="XM_056931195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH14"/>
    <dbReference type="GeneID" id="81621444"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="13">
        <location>
            <begin position="33"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="191"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5492846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="360" mass="39428" checksum="B9E75048F4A4568F" modified="2023-11-08" version="1">MPYPEEAQGFQVDGPETYTEFHKRFYKLKPFGDYDVDVQIEACGVCGSDVHTISGGWGEQKFPLCVGHEIIGRAIRVGPKVTLIKEGQRVGVGAQSYSCGECKQCRNDNETYCPVMMMDMYGSEWPETGIVSQGGYSSHVRTHEHWVFPIPDALDTNTVAPMLCAGLTAYSPLVRNGAGPGKKVGIVGLGGIGHFGIMFAKALGAETWAISRSRAKEADARKLGADGYIATAEEGWEKEHRFSFDLIINCANSSEGFDLAKYLSMMDVHGRWVSVGLPEEEGQVIKAQSLISNGVLIGASHLGSRREMLDMLQLAADKGLKGWVEEIPISEEGLKQAMLRMKKGDVHYRFTLTGYDKAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHE0</accession>
    <name>A0A9W9XHE0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_001659</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Lipid-anchor</topology>
            <topology evidence="1 8">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793293.1">
        <property type="nucleotide sequence ID" value="XM_056931262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHE0"/>
    <dbReference type="GeneID" id="81621511"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF8">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041011353" description="1,3-beta-glucanosyltransferase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="381"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="391"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5492913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="453" mass="48310" checksum="957CA15519BDF3FD" modified="2023-11-08" version="1">MLSSFTLSAVPLLLAGLQAATVNAVPTISAVGSKFFYENGTQYFIKGIAYQLKPHDPLIDTAQCKRDIVRMSELGTNAIRVYHVDPSADHKGCMDAFAAAGIYLFVDLDTFDTQINQDAPQWSHSQYDAFTKVLDEFQQYDNTAGVFVGNEVLTTSNGSHAAPYVLAATRDIKAYRDKKGYRQIPVGYSAADIAELRPMLQNYLACSHNASERLDFFSLNAYEWCGQNTYQTSGYSALQAAAANYNIPIFFSETGCNTPKPRTFDDQAAIFGANMVDTWSGSMIYEWIEETNDYGLISYGPSVDPATATDPNIEDGYTRQGTPTPVMPDFDNLKAQWATLNPTGVALSDYKKRTGAITPVACPSSTSGGWAVDPSAPLPSLGQSFKKGAEGSAITSATQSGTSAGTSTSTSASSSQASSAASPAGHHASSVPSHLLTVSVLLSAGIGAVALWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHP2</accession>
    <name>A0A9W9XHP2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793459.1">
        <property type="nucleotide sequence ID" value="XM_056931428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHP2"/>
    <dbReference type="GeneID" id="81621677"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021582">
        <property type="entry name" value="Aim21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11489">
        <property type="entry name" value="Aim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="696"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="898"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="932"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="948" mass="102282" checksum="6CF40DAAEF9AF9DE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XID4</accession>
    <name>A0A9W9XID4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793550.1">
        <property type="nucleotide sequence ID" value="XM_056931519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XID4"/>
    <dbReference type="GeneID" id="81621768"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018803">
        <property type="entry name" value="Ish1/Msc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10281">
        <property type="entry name" value="Ish1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040968680" evidence="2">
        <location>
            <begin position="21"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5493170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="546" mass="60676" checksum="E20279D38B11202C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLF0</accession>
    <name>A0A9W9XLF0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Metal resistance protein YCF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_000302</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794199.1">
        <property type="nucleotide sequence ID" value="XM_056929906.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81620155"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042592">
        <property type="term" value="P:homeostatic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000450">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="964"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1008"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1094"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1198"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="306"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="626"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="971"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="1289"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="856"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="861"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5495186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1541" mass="171890" checksum="7BAD1FF799C90BEE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM09</accession>
    <name>A0A9W9XM09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_000474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794371.1">
        <property type="nucleotide sequence ID" value="XM_056930078.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81620327"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="4">
        <location>
            <begin position="33"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="6">
        <location>
            <begin position="398"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="5">
        <location>
            <begin position="683"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1009"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1127"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1241"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1274"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5495358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1345" mass="149611" checksum="4412ED39D4309F63" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM27</accession>
    <name>A0A9W9XM27_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794018.1">
        <property type="nucleotide sequence ID" value="XM_056929725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XM27"/>
    <dbReference type="GeneID" id="81619974"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET_dom"/>
    </dbReference>
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        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="34"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="364" mass="41613" checksum="6F638F678A2FB610" modified="2023-11-08" version="1">MDKTKDKNHRERSLPVHFQYPSSLIYSCLSAAYLRLRIPKSAPYELKPAGNHGWGGFATRFIAKGSLIYREQALFTLQPRGAQQVHDYTILWKVRQLSAQDKETFNLLVKAAALDGDDKVSNVFIKNYFRLVNVANELGVPTRSHQLGFFVFLSRLNHACVANAYVPQNEGKYISCYATKDIQPGEEIMFSYCADFESMQMEQRHRLLRFTCRCVACAPGTAFHELSEIRRKLIRGLNFLTQGMDLAYPRRDGHGPSGIIADPILREAAKELYMPLMSRLFYESMIGLLLEEEGMMNAMIEKEIIARMRGAVRLLQEADNMVLALRIMKQKRWVDKWLVASQTLHKPDLGDIDGYLMLNMTCTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM81</accession>
    <name>A0A9W9XM81_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794584.1">
        <property type="nucleotide sequence ID" value="XM_056930291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XM81"/>
    <dbReference type="GeneID" id="81620540"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="122" mass="13268" checksum="68D74EBDA3513BC0" modified="2023-11-08" version="1">MARRPSLDSERPMMANSTRTSKRFSTVSGSPSLANSERTIGSLPPGDPRVVDITNYGDGVERLENKPLQKQRFVPTPEKTDDLNKLALGAKVERALGRRMTSQDAVMRKPVLTEKAAAAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMC1</accession>
    <name>A0A9W9XMC1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_000715</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794612.1">
        <property type="nucleotide sequence ID" value="XM_056930319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMC1"/>
    <dbReference type="GeneID" id="81620568"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="422"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="11">
        <location>
            <begin position="134"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="506"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="543"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5495599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="557" mass="60783" checksum="40F0B52E5DDAC6AF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMH1</accession>
    <name>A0A9W9XMH1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Myosin type-2 heavy chain 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_000105</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Binds to cdc4 and rlc1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794002.1">
        <property type="nucleotide sequence ID" value="XM_056929709.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81619958"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902404">
        <property type="term" value="P:mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000001">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055914">
        <property type="entry name" value="DUF7491"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24319">
        <property type="entry name" value="DUF7491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="13">
        <location>
            <begin position="110"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="164"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="735"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1660"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2364"/>
            <end position="2395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="934"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1606"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1715"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1827"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1953"/>
            <end position="2058"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="2206"/>
            <end position="2353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="2382"/>
            <end position="2395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="257"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5494989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="2395" mass="276303" checksum="7F1AE0E7B1142F0A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMT6</accession>
    <name>A0A9W9XMT6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 17">Elongator complex protein 3</fullName>
            <ecNumber evidence="17">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">N7539_000566</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17 18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17 18">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the ELP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="17"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794463.1">
        <property type="nucleotide sequence ID" value="XM_056930170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMT6"/>
    <dbReference type="GeneID" id="81620419"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
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    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
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    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
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    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
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    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12 18" id="KW-0408">Iron</keyword>
    <keyword evidence="13 17 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 17" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 17" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="20">
        <location>
            <begin position="102"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="19">
        <location>
            <begin position="416"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ5495450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="578" mass="65234" checksum="96B450DAA07E8D26" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN14</accession>
    <name>A0A9W9XN14_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Meiosis induction protein kinase IME2/SME1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_001107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795004.1">
        <property type="nucleotide sequence ID" value="XM_056930711.1"/>
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    <dbReference type="GeneID" id="81620960"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000233">
        <property type="entry name" value="Meiosis induction protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000314">
        <property type="entry name" value="Serine threonine-protein kinase mak"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="358"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="718"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="463"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5495991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="757" mass="83425" checksum="8924E2D5086FB076" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN17</accession>
    <name>A0A9W9XN17_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Queuine tRNA-ribosyltransferase accessory subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuine tRNA-ribosyltransferase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_000375</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794272.1">
        <property type="nucleotide sequence ID" value="XM_056929979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN17"/>
    <dbReference type="GeneID" id="81620228"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.105:FF:000007">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase accessory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03043">
        <property type="entry name" value="QTRT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028592">
        <property type="entry name" value="QTRTD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050852">
        <property type="entry name" value="Queuine_tRNA-ribosyltrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="25"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="402"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="442"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5495259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="468" mass="51509" checksum="33AC7D77F265AD2C" modified="2023-11-08" version="1">MESRTSSSHEMSFTVLSSAAPVMAPRVGTLALAGRQALATPNLVPLTSRGTVPHISHDMVRKETAIKNFYVGLEDFIERKHPAPIYSVPVKANESPLKKFICLKNDDIVLLGSRRFPAIACPPNNTETSIAISTSVGFRQLESSRYIEAIQTLKPDIAIGMADLVIGRAPGLKRRGKMVDRTHAYTRDALDKLFGPSVTEGKPRSTNYFAPILPLDNAQQSIYLDDLAEEFRDRISGLALYESASLSFISESLSTLPRLLLSEPTSPHDVLREIALGADLLTVPFLQTCSDAGIALDFTFPAPPATLARSEAQPLGFDLWSSENTKNTSPLADGCECYACRKHHRSYFNHLLRAKEMAAWALLQIHNHHVMDRLFAGARTSIERGTFEQDVQDFNRAYVSDLPDRTGEGPRLRGYQMPAAGPNQPRRMPKVYGRLDDLSQKFAESESSVATPDTDADGLEKHGFAGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XND7</accession>
    <name>A0A9W9XND7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795136.1">
        <property type="nucleotide sequence ID" value="XM_056930843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XND7"/>
    <dbReference type="GeneID" id="81621092"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5496123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="178" mass="19153" checksum="44243522409CAB27" modified="2023-11-08" version="1">MDVFRAYTYSTAGWLTLQSLPLILSPGIITALMLDETRQASSVEVYFARCLGFSLLTIAVLTAMLTGSIPLTSTISEPVTTEDSDPKAPYANPTLMITFLFQSACAFYAYTRFVTTGQGIFTLGVAVNASIAAVGLWCLLFATSNGKISRKTGVDKRASGYPFANSEAAKRHPNKKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XNL7</accession>
    <name>A0A9W9XNL7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_001001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794898.1">
        <property type="nucleotide sequence ID" value="XM_056930605.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81620854"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051254">
        <property type="term" value="P:positive regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16618">
        <property type="entry name" value="mRING-HC-C4C4_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12438">
        <property type="entry name" value="RRM_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000257">
        <property type="entry name" value="CCR4-NOT core complex subunit Not4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034261">
        <property type="entry name" value="CNOT4_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039780">
        <property type="entry name" value="Mot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039515">
        <property type="entry name" value="NOT4_mRING-HC-C4C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14570">
        <property type="entry name" value="zf-RING_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="18"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="231"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="341"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="449"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="735"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="796"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="965"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1034"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1506"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="743"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="854"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="876"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="966"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1034"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1050"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1074"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1142"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1180"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1204"/>
            <end position="1214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5495885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1541" mass="166093" checksum="9D9E6802FD9B4012" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XPB4</accession>
    <name>A0A9W9XPB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_001020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMP52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794917.1">
        <property type="nucleotide sequence ID" value="XM_056930624.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81620873"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Protein FMP52, mitochondrial"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF7">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD_binding_10"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
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            <begin position="8"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5495904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="238" mass="25056" checksum="97AA3A933B1B981F" modified="2023-11-08" version="1">MANVALIGCTGMVGSHILTSLLAHPGVTRVDTLSRRTPNAASSAPQSKLTAFVSDKTETWASQLSALSPTPDVFISSFATTRANAGGFENQYKIEHGLNIELARAARDAGVKVYVLISSANASKDSSIPYTRMKGEIEEDVKALGFDRTVIVRPGLISGTREESRPLEAAVRFIAGWAGKLHSGLKDGWAQDSDVIARAAVKAGLRALEGDVPAGSEKVWRVDGSQIIALGKEAAASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ06</accession>
    <name>A0A9X0BJ06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785604.1">
        <property type="nucleotide sequence ID" value="XM_056939109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJ06"/>
    <dbReference type="GeneID" id="81629359"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5466558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="307" mass="32845" checksum="7191CD5DDD003017" modified="2023-11-08" version="1">MATQGSYTQYASSQSQHATPLSALPAPSPAPTPPPSNSQRSGYPAVFAQHGVPSGARDLGPQSSSYRPPSPASRPSNAAFGTRTEPVTTTQSSNSPFALGPRQMVQQHSFASTASPTPGNTPQHSQSYQQHVQTLVNGAHQPHRSTPVSMAGGPSQYGHAPLTPQVSGRAMPSLASLGRSYTPHRLCTPVVWGTVHRRHRQVQGVFSRCIIEHLARESMSPTRAAITASTVKGPHKGGCQAQCALGRSHHASPDIHDCNHMACPFEIDLMIPLYIRRRKRAFSVCLLIICASEITSPLVFDSLCIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BLK7</accession>
    <name>A0A9X0BLK7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008584</name>
        <name evidence="2" type="ORF">N7539_008804</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786561.1">
        <property type="nucleotide sequence ID" value="XM_056938179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BLK7"/>
    <dbReference type="GeneID" id="81628429"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5472015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="228" mass="25373" checksum="1714D68EA0E8D5F5" modified="2023-11-08" version="1">MNGTSADDLQKAALEIRPNRTSPRKVERTRWGLLNDSSWAHQQGETSKCHYACTSDSVHPARTQFHPRLNHSEENLDHQLTRSEEMSNLDSNLNAIDTGGPFGEIGCLETPSMGDFTLFTSNTSDFSTYSPSTLQIQGFSASLLTSHLCGSDAHWQSEDYRGDDSTPRYYSGNPHYPVDSPISRQDTSYLAVGSSPQVFAEMPMTGQWPSNYDDYSIGLHSDSLFCPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BLT1</accession>
    <name>A0A9X0BLT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786571.1">
        <property type="nucleotide sequence ID" value="XM_056938189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BLT1"/>
    <dbReference type="GeneID" id="81628439"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5472025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="180" mass="19951" checksum="8D6DA2A12703BFFE" modified="2023-11-08" version="1">MAGPHRTSLSLPEECHARVFWAAHILYYLTKNQSHEELLKAENTVESGSQTDDSSDHETDYETEKNMMLSGPRDSIRQKFLDCIAQLLSPCKGWDGVTATAIREGEAGVEVDIARNDGFLSGGDCFDSEIMGYCKMLEEYLEGNTGGLQLSQIATGPAGVVGHLWDSGWHETLEQAEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BLV5</accession>
    <name>A0A9X0BLV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786349.1">
        <property type="nucleotide sequence ID" value="XM_056938341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BLV5"/>
    <dbReference type="GeneID" id="81628591"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="65" mass="7220" checksum="A5D17E9A84ACB64A" modified="2023-11-08" version="1">MGRSPQNGHQEPNRRSAAMTAPRSRVRNNNRNHGVSAASERTPAGLSHRKTGQAVQWTLSDDKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BN67</accession>
    <name>A0A9X0BN67_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786791.1">
        <property type="nucleotide sequence ID" value="XM_056937699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BN67"/>
    <dbReference type="GeneID" id="81627949"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="378" mass="42448" checksum="3AF5FCD6B7B14159" modified="2023-11-08" version="1">MPKKERFLVLSPVVCPMDSLLPLKQLPDTSRLMWTSPRLFLLKRCESIIEGIKAVNSIVSKVMVMTPWSMGLHIFPQTKSLRQRSKSRIVFRQMSRYHQKCSILNVHNLYPSLCSPCEGLQPGVFTDISAGQVGSYLNDCPCHWWKNQSWVPYGTETASLWCKRDSVLPLSCRRGRSIFQGNPISHNLDGPSASGNDSRPTGSPIERSLSPIVEHLLADHASNVYQPRIKGSVQESWVSRIESGGEKLTIARANKKEESPMTLKRQPGQISNNSSWVHFPQEIPYEDLINVRFVNAFVPLIVCRELLPCMEAGVTMRGTDVSEARATRKTPGSLVCQSLLIRVPFLPGHPSPLTSAGHQDLFRIKCFGISSCHERHCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BP46</accession>
    <name>A0A9X0BP46_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788074.1">
        <property type="nucleotide sequence ID" value="XM_056937275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BP46"/>
    <dbReference type="GeneID" id="81627524"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="531" mass="59462" checksum="58E5BB1DDFADEAC8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BP76</accession>
    <name>A0A9X0BP76_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_007662</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Also a component of the nuclear pore complex.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Cytoplasmic dynein consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the dynein light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788062.1">
        <property type="nucleotide sequence ID" value="XM_056937263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BP76"/>
    <dbReference type="GeneID" id="81627512"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043935">
        <property type="term" value="P:sexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 11" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5477518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="94" mass="11007" checksum="291B1DCD152758BC" modified="2023-11-08" version="1">MATEKKEKMEAQIKSVDMTEDMQQEAIALAIEAMEKYHIEKDIAQYIKKEFDSRKGATWHCVVGRNFGSFVTHETKHFIYFYLGHCAILLFKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSK0</accession>
    <name>A0A9X0BSK0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_006109</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788635.1">
        <property type="nucleotide sequence ID" value="XM_056935711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSK0"/>
    <dbReference type="GeneID" id="81625960"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5482663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="55419" checksum="457F0B5625B297FC" modified="2023-11-08" version="1">MADNIPAELVESKNRDSITDVRSERKVQSPVQPQKEPEEKPQLDVPPDGGYGWVCVACVFWINAHTWGINSSYGVFLSHYLSHNVFPNTSALSYAFTGGLSISCALLVAPLATYLIQTFGTRLVINLGIFFETLSLIGSSFATQKWHIFLSQGVCFGWGMGFLFVGSVGITPQWFLKRRSFAMSITAAGSGFGGLMYSLAVGAIIPRLGLSWAFRILGIISCVVNLVCGNLLRDRNKLIGSRLVAFHMPLLRRPEFVLFLAWGVFSMLGYVALLFSVANFALSVGLSSYQGSIVSAVLNLGQGLGRPVVGIFSDRLGRINIATILTFVCGLFCLVIWVFADSMGVVCFFAVLVGTVAGTYWATVSPVLAEIIGLKDLPSGLSITWLMLVAPCTVSEAIALELRTSQRGGGVSYLRVQIFTGFMYIGAAICLWLVRGWKVGELECAQRQEQNRQESLNRVPLVLVGPTDTSAEKEDRSAIASTTGSEDTMSKQNWAPAKLMQRMIALKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSR6</accession>
    <name>A0A9X0BSR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788472.1">
        <property type="nucleotide sequence ID" value="XM_056936537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSR6"/>
    <dbReference type="GeneID" id="81626786"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5481042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="108" mass="12370" checksum="0B90207D780D36FB" modified="2023-11-08" version="1">MANEERTRYYQDWENYFPASEQKTGEQDSTITDVRTQNAAQDLRVAAFAHGRRRKAHGQIRLPIQAIVHGCDVISDAHILLDTRPAEETHFFEMTALAKDKSVRGIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSX6</accession>
    <name>A0A9X0BSX6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788652.1">
        <property type="nucleotide sequence ID" value="XM_056935728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSX6"/>
    <dbReference type="GeneID" id="81625977"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599:SF1">
        <property type="entry name" value="GPI-ANCHORED PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599">
        <property type="entry name" value="GPI-ANCHORED PROTEIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040911579" evidence="1">
        <location>
            <begin position="20"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5482680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="259" mass="26365" checksum="4A6A9B5755E1D121" modified="2023-11-08" version="1">MRASWWIGICALFAPSVTSTETAAFSEPYTVESNRRAFEVLQLLKRAGNNCPWGYTPCTSEGNSNACCRPDTNCSVDAANNIACCPTGAVCTGTLTGASTATQTGSSFMFPHGATATTTSSTTAPHGAAVTGSIVAGAYPFVYVPTTFPNSAVCSSYYSLCQSEYTQCTANLMGRYGVTVGGVGGAGVTVEAVTATSQATSICSSLSQQACHGLQLNYCASVATGATSEPNGNGALLAQSTSLYDLMAGVMVGIAAVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BT09</accession>
    <name>A0A9X0BT09_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788742.1">
        <property type="nucleotide sequence ID" value="XM_056935818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BT09"/>
    <dbReference type="GeneID" id="81626067"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5482770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="740" mass="84895" checksum="D17C909ADFE33CB8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BU66</accession>
    <name>A0A9X0BU66_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Minor allergen Alt a 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789255.1">
        <property type="nucleotide sequence ID" value="XM_056935383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BU66"/>
    <dbReference type="GeneID" id="81625632"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5483985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="201" mass="21626" checksum="BA17D44821FB9C75" modified="2023-11-08" version="1">MAPKVAIVFYSMYGHIVKMAEAEKKGIEAAGGQADIFQIAETLSEDVLAKMHAPPKTSYPVAEPTDLLEYDAILFGIPTRYGNFPAQWKTFWDKTGGIWASGGFAGKYAGTFVSTGTPGGGQESTVMSCMSTFVHHGFNFVPLGYKTTFPQLTNLEEVHGGSPWGAGTFAGPDGSRQPSALELQIAELQGKWFYETVAKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUT3</accession>
    <name>A0A9X0BUT3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Enoyl reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_005536</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790332.1">
        <property type="nucleotide sequence ID" value="XM_056935138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUT3"/>
    <dbReference type="GeneID" id="81625387"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF1">
        <property type="entry name" value="TRANS-ENOYL REDUCTASE STHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="19"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5485548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="362" mass="39028" checksum="45BE7BF8F1F77DBC" modified="2023-11-08" version="1">MSFSHDIPSSQTAIIQHEGGNLRITPELPIPSLEPFHILVKTAAVALNPCDFKMPLRFPTPGLWDGCDFAGTVVALGSQAAANTRFKPGDRVFGAVQGSNQSDATSGAYCEYLRIDEDFPFHIPESMSFQQSLGISGTGIATLGVALFWSLQIPGSPDAPADTSVDVLIHGGSSTVGLLAIQMVKLCGHRVITTCSPRNFDLVRAYGADLVFDYKSETCAKDIRMATKNTLRYALDPFAEAKTVRLCQEAIGRTGGRYCALEQYQEHLCTRKTIKNDLVMGGAISGKGVQLPEPYGIPARAEIGVWARSWYRLVEHLIHDGKIRGCPIKVVPGGFQGILHGLELLKGGSVSGQKLVVSLEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUV0</accession>
    <name>A0A9X0BUV0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_004983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789779.1">
        <property type="nucleotide sequence ID" value="XM_056934585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUV0"/>
    <dbReference type="GeneID" id="81624834"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5484995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="170" mass="18987" checksum="2B640A598D6F1C3F" modified="2023-11-08" version="1">MDPESSKLYRPTGLSSSCNESAYRRLAARGYTPKTLVKATRKVAVTPIALNLCVPTFRSHPMIQGPMKISLPRSASESIIKIDLGVDREQTSGLMFKRLFKTQTVQIANCISPWPILFCSSPEYGADRQCGSACKTEHQVERTRTRRVNFQYLTNGVCFYVGMAKNQSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BV67</accession>
    <name>A0A9X0BV67_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC multidrug transporter atrF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_005569</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790365.1">
        <property type="nucleotide sequence ID" value="XM_056935171.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81625420"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001465">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1126"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1150"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1192"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1237"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1270"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1390"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="92"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="789"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="739"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="753"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5485581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1419" mass="158076" checksum="964FE143DBD794A8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXK8</accession>
    <name>A0A9X0BXK8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">GATA factor SREP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_003750</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790893.1">
        <property type="nucleotide sequence ID" value="XM_056933352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXK8"/>
    <dbReference type="GeneID" id="81623601"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034757">
        <property type="term" value="P:negative regulation of iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000039">
        <property type="entry name" value="Siderophore transcription factor SreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF335">
        <property type="entry name" value="IRON-SENSING TRANSCRIPTIONAL REPRESSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="12">
        <location>
            <begin position="93"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="12">
        <location>
            <begin position="243"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="204"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="299"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="370"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="498"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5488860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="528" mass="55952" checksum="1A1A8EEA13F21A24" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXY8</accession>
    <name>A0A9X0BXY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxal reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791344.1">
        <property type="nucleotide sequence ID" value="XM_056933803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXY8"/>
    <dbReference type="GeneID" id="81624052"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="321" mass="35224" checksum="C9FC6CE210100E9D" modified="2023-11-08" version="1">MPTLVGKEIGPIGYGTMRMTWQPEPPSQEVCFETLNKTLELGANCWNAGELYGTPEYNSLHLLNKYFSKYPQNADKVVLSIKGGLKPGELAPDGSEKNLRRSVDECLRVLDGKKTIDIFQAARQDPNYPVEHTIEVLAKYVQEGKIGGIGLSEVDAETIRRAHKVHPIAAVEVELSLWSTDPLENDIAKTCAELNIPLVAYSPLGRGVLTGSLTSAEDIPEGDFRRHLPRFQGENFQHNLKLVKEVKNLATGKNVTPGQIALAWVRTLSNKPGMPTVIPIPGGTTVDKVIQNMSGVDALTDEDMAEIDAILKQHTMAGTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYM1</accession>
    <name>A0A9X0BYM1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase II</fullName>
            <ecNumber evidence="3">3.5.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_002407</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791969.1">
        <property type="nucleotide sequence ID" value="XM_056932010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYM1"/>
    <dbReference type="GeneID" id="81622259"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF29">
        <property type="entry name" value="GTP CYCLOHYDROLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="10">
        <location>
            <begin position="191"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5490840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="379" mass="41367" checksum="AEFE0DCDD55873A4" modified="2023-11-08" version="1">MADLPAHASPKITPQSSSSTDRHDDLADDLSQGSGITTGEQTPALPDSILSPAFTPPATPGGTLHLTSNPTHLLHESQAASIRHSGQHKKGPKLLEQLPQVECIVRARIPTTNGAEMFLHLYHNDIDNKEHLAIVFGSNIRSRSLDRVRPGETEMDRMIRGAYVGKLHPGRTSSWYDEEKNPESAQAARMEPPLVRIHSECYTGETAWSARCDCGEQLDEAARLMSFPVENLAADAPPETQSLRSRSAGGVIIYLRQEGRGIGLGEKLKAYNLQDLGSDTVEANLLLRHPADARSYGLATAMLMDLGCGADVNAEGIRLLTNNPDKVRAIEGPNREVLVKERVPMIPLAWRTGGERGIKSSEIEGYLRTKISKMGHMIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYR3</accession>
    <name>A0A9X0BYR3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791525.1">
        <property type="nucleotide sequence ID" value="XM_056933984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYR3"/>
    <dbReference type="GeneID" id="81624233"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019727">
        <property type="entry name" value="ATP_synth_F0_fsu_mt_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10791">
        <property type="entry name" value="F1F0-ATPsyn_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="153" mass="16626" checksum="86C8EC45BBB6FED1" modified="2023-11-08" version="1">MSYIARRGLSTLIPPKVRPTPSSGRIRGGKRGILNNSTITDIVVDRFSQCESLKASSHVVISPDNLLQDPFPPDGHISIPNSFPDSIVSTVLEFVTDMSIRKAIGAAQDAARMERVVSFYAGLPRGPAPQTKATGLLGRYQARYFNKNSAARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ93</accession>
    <name>A0A9X0BZ93_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792167.1">
        <property type="nucleotide sequence ID" value="XM_056932208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ93"/>
    <dbReference type="GeneID" id="81622457"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="506" mass="55980" checksum="82B5AFADED6F65AE" modified="2023-11-08" version="1">MSAFDRVRRLVGLEGGIRRQEPSPATSSSSSAVESSGDDLQSRVQVFESRGRSPGVMTNPTRAGARTDSPSPTGVETACEQRLSASLPTVPLTLTSNLDWSGHDNDRDETETFLDEEQFVADNSPVLPSPQHTLNHFLTEGYEVDPPLFVDADAANIEGSDSASSSKAPFTRGHRRRSTHVTRRDLEKFQQEVLGVENTATWYDEENGSSRPIDPFDPQLEALNRAFEAADMSMSSGAGGLPAGNVPNSGLYANYTENSPTPGMGSMSRQPSSPAHPHPGPQVNGGGPGAGGMPMNAGHQMDLHHLYEMVLELSEVLKNNREVTKSIVSSAEEIMKHGTSEDASTALRQVNGEITAARISELERALAKEKRLNEVLKHEQAENVKLIGDYETSVGLMVEQIRNYCQNNNMHYLYQKRHYNNLLQAERDAHLDSRLDRDYWHTQTMRCAQMIRTASRLRSEEEELPIRIVAGLQNEVRAYRNALGMEPEKPEQEYGWEILKDVPGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZF6</accession>
    <name>A0A9X0BZF6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">14-3-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_002800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792362.1">
        <property type="nucleotide sequence ID" value="XM_056932403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZF6"/>
    <dbReference type="GeneID" id="81622652"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="3">
        <location>
            <begin position="196"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5491233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="352" mass="38464" checksum="A7B578CAF38F1D19" modified="2023-11-08" version="1">MANLQDDAQCEGAAIEKWMASSEVDQKALGNFAAGTALENPYLSAMLYRVLGVSVMLSKKLIRARRLRRLDTTRETKSLQLYHHLIWLSREGLIILEHYVLPLVAAFVELKVLTYKLRASFYHIFVLFYNRPVIIPPDADPPAELKRDSIYNPDLLTALEASAIKSHGRTSRPPGLAPVQPPQNASSFLLPPLDYTSTATACFNYASMLADKLLPGSHPLRLSVKLEYAAYLYDCLQDPVSSRRLAKRAIADVYNAQEGMDDESFEDAAEIVGILGKMVKRGGKPGSSTAASSVSRGEHSRSRSSQCPSHFDISAPTTVSPGPVTKPSPNPSRAAVATPEPAVPSTNMMNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C050</accession>
    <name>A0A9X0C050_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_001476</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793110.1">
        <property type="nucleotide sequence ID" value="XM_056931079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C050"/>
    <dbReference type="GeneID" id="81621328"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01370">
        <property type="entry name" value="KISc_KIP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000053">
        <property type="entry name" value="Kinesin family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
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            <end position="142"/>
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        <source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5492730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="8">XPG-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Penicillium diatomitis</name>
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            <taxon>Pezizomycotina</taxon>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GEN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <end position="98"/>
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    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5492894.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="869" mass="95823" checksum="D35433E312E10960" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0L8</accession>
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        </lineage>
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    <reference evidence="3" key="1">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TTL"/>
    </dbReference>
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        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="3"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5493255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="755" mass="83912" checksum="0335081503232644" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0U2</accession>
    <name>A0A9X0C0U2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_002226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793860.1">
        <property type="nucleotide sequence ID" value="XM_056931829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0U2"/>
    <dbReference type="GeneID" id="81622078"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053201">
        <property type="entry name" value="Flavunoidine_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350:SF19">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5493480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23378" checksum="A362C27D11E86CF2" modified="2023-11-08" version="1">MGSQTLTQTVSEVAEEHGQAKLTDPTLMALPAAPAFPLEQNELQDLMEYKRTPEGQLSTVSRVNAPRGSHLCYVRTQISVPESTWSSFQTSKSSHAEFNSALVYMNHSCAPTVELEVFAPDSRGEYPNGVSGELRVVQDRDLRVGDELTWFYPSTEFISPRPFECLCGAGKELCIGTQRGSNFLSEEVLSRYFINNHVRELRAQKRAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2G8</accession>
    <name>A0A9X0C2G8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_000577</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794474.1">
        <property type="nucleotide sequence ID" value="XM_056930181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2G8"/>
    <dbReference type="GeneID" id="81620430"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="67"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5495461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="540" mass="58801" checksum="2E3A7190886BCE8C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2J6</accession>
    <name>A0A9X0C2J6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial fusion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_000336</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794233.1">
        <property type="nucleotide sequence ID" value="XM_056929940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2J6"/>
    <dbReference type="GeneID" id="81620189"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5495220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="54522" checksum="C20BF166CF75B40C" modified="2023-11-08" version="1">MATREGINPLRPYYIPQSGLSPTVSNVTTEVTSSSSAQVFGSTARDLIPDIDYSDYLDSSPSVSDWVRDALNRALVRYTKVLTAQPFDVAKTILQVYVVPDSIESSEQRKKTSGTEDNAYESDNESSGDESVYFTSAAPATPSSATSRSRRSRHHQITDRSGYVRPEAATALPKYALTLRNPDSLMDVLSQLWSTSGPSSPWKASNATFIYSLLLPTLNTFIRSLLSAIVGFPEEDIASSMAADILTAPSPLATLILSFISSSLSAILLSPIDTARTFLMLTPAIHGPRSLIHAIRQLPTPNCTIPPHLVPITILHSSLPNFITTSAPLFLKSYLSIDPLLNPSMWNLFSFLTSGLELAVRFPLETVLRRAQIASYTSLSLRQKSAGGSLDAASIDATDVETIVPTPRTYRGVVGTMWHIVQEEGVSSTLSDAERARLAVGKGTTQQHTGKRRQGQGIKGLYRGWRVGMWGIAGIWGASLLGGFAAGSDEEAAMLGGSSQTSGGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKA9</accession>
    <name>A0A9W9WKA9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_009533</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785623.1">
        <property type="nucleotide sequence ID" value="XM_056939128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKA9"/>
    <dbReference type="GeneID" id="81629378"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF142">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040855106" evidence="4">
        <location>
            <begin position="23"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5466577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="478" mass="50426" checksum="3E71CD0642433A6B" modified="2023-11-08" version="1">MRASIQSGLLLAASLSTSVVEAERVLGAYIYARHGDRTAKVLGNTQLTNLGYREVFDAGSFYHDRYVAAGSDKQIEGISPVIVNPAQISASSPADAVLQNSATGFLQGVYPPAGSSANQTLANGTTVDSPLQGYQLIQIAATSSSNSNEGQTWLQGSSECNKATVSSNNYYVSTAYETMLQSTKSFYQSLSPLINSTFSPSLMSFKNAYSIFDYLNVGRIHNSSAEASANQATYDQLLQLANNQQYNLAYNSSDPVRAIAGAVLAGEILSSFNETIASGGKSKLAISFGSYGTFLSFFGLVQLPAASVDFTGLPDYASSMAFELVTNATGTGMPSQDELSVRFMFHNGTLTEGAQPTVWPLFGQTKDLLSWSDFKSGLEKVAVSSDAQWCDLCGNTDGKCASSTTSSAQATATSSPSSSSSHGMSRAVAGVVGAMVTLAVILGLEALFFLVGGFRISKRNKNRAEVITVNDTASVEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKF7</accession>
    <name>A0A9W9WKF7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_009423</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785740.1">
        <property type="nucleotide sequence ID" value="XM_056939018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKF7"/>
    <dbReference type="GeneID" id="81629268"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF164">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5466694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="57124" checksum="8945C4B8C6242889" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKG4</accession>
    <name>A0A9W9WKG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_009577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785667.1">
        <property type="nucleotide sequence ID" value="XM_056939172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKG4"/>
    <dbReference type="GeneID" id="81629422"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5466621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="88" mass="9527" checksum="E6701D02B954B32F" modified="2023-11-08" version="1">MLEVELVEVGESGSGGSLGGDGGGISTPHNRSIVLPAGRQLRFLFKPKHDFSVREFKRGKAIILGFGFEEELSLNTAARHDARNGQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKN9</accession>
    <name>A0A9W9WKN9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Stretch-activated cation channel Mid1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785771.1">
        <property type="nucleotide sequence ID" value="XM_056939049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKN9"/>
    <dbReference type="GeneID" id="81629299"/>
    <dbReference type="Proteomes" id="UP001148312">
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    </dbReference>
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        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024338">
        <property type="entry name" value="MID1/Yam8"/>
    </dbReference>
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        <property type="entry name" value="AEL197CP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12929">
        <property type="entry name" value="Mid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040798733" description="Stretch-activated cation channel Mid1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5466725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="651" mass="70899" checksum="A2AA916B16DE05C6" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKP1</accession>
    <name>A0A9W9WKP1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calcium/calmodulin-dependent protein kinase kinase cmkC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_009440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Petersen C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="BcCMK3, calcium/calmodulin-dependent protein kinase"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
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            <end position="375"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="62"/>
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    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
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            <position position="108"/>
        </location>
        <ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5466711.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="878" mass="98001" checksum="05195EF55BD72636" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKR5</accession>
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        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Penicillium diatomitis</name>
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        </citation>
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            <strain evidence="4">IBT 30728</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="Proteomes" id="UP001148312">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AlkB-like"/>
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    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
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    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF1">
        <property type="entry name" value="DNA OXIDATIVE DEMETHYLASE ALKBH2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        <location>
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            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="288"/>
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        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="236"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
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    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR632852-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5469291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <sequence length="392" mass="43645" checksum="C25ACDD86A8CEC89" modified="2023-11-08" version="1">MSKRTLESFFKPKASTNPAKRVKTNDTSNDGPLETNETDAKDDATTDTGPPDTHPSYPIPIPQLPSHISVGLTHGTPAKDPRAINNQPDLDLLYFQPFIARPTANELFKFLRRELPFYRVQYTIKRGTLETEINTPRYTTVFGIDDTSMFIHDPDRQPSSKGSDSTPDLTTEHKQGHPQSAPFSTLIPVEKTSKTPIRASKYQYTPRPIPPCLTHLQTAVESATGATYNFCLVNYYADGNDSISYHSDDERFLGALPDIASLSLGGEREFLMKHKPPPQTSQETSSPATITNPAPGSVAQTQPIKMPLSSGDMVVMRGSTQSQWLHSIPKRKGKRGDAVRGRINITFRRAMIPAGTNNYYRYNVGVGPVWRWDESEQEMMARPEKFSDEGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL59</accession>
    <name>A0A9W9WL59_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase CHL1</fullName>
            <ecNumber evidence="18">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-dependent DNA helicase chl1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Chromosome loss protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19 20">DNA 5'-3' helicase CHL1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">N7539_009084</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="18"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786056.1">
        <property type="nucleotide sequence ID" value="XM_056938679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL59"/>
    <dbReference type="GeneID" id="81628929"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001372">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002774">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 25" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="24">
        <location>
            <begin position="7"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAJ5469466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="864" mass="96168" checksum="06B925E8A0FBDDA8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLA4</accession>
    <name>A0A9W9WLA4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MGS207 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786166.1">
        <property type="nucleotide sequence ID" value="XM_056938789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLA4"/>
    <dbReference type="GeneID" id="81629039"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF6">
        <property type="entry name" value="MGS207 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5469576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="47369" checksum="20FE993DF09F7EE3" modified="2023-11-08" version="1">MFQIPSLKLSNLFSWGEKHPIDLPTVKVHDLETSEEKGTRTLKHLLKLNHANHAILWNHRKFHNHAPHLLSAAYLQGADADDLARLYESESKELEEWDDSPAEVTEDDWREFVGRREYQKAFVDFFEDEMVRLGYDWKQVVAEYLFSGDEPLFNSVMADLGHPLIHLAYAYEMSSREVGMESLGLAATCYNKIHKYLDDPVFNQVEAPYHASSLFEIIERVHTDKRLDNLFVTPGDHNVETLFTDHEALLLDHWNAWTITNPTEQFRESQRLAAALLVATHTDTSEKYDFFLVHVLTTSHAVRVLLPLIPAKFQIPLVRQWWLITLAVYIAQLRPQIELDVVRHIDLKGRDWAWTAEQAVKGRHSTDSHYVKALRSLHECAITWGDQDDLFLKAAVKFAEEFTEWGGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLB4</accession>
    <name>A0A9W9WLB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_008881</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785853.1">
        <property type="nucleotide sequence ID" value="XM_056938476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLB4"/>
    <dbReference type="GeneID" id="81628726"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="3">
        <location>
            <begin position="257"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5469263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="401" mass="44641" checksum="9FD03BBE68F4638A" modified="2023-11-08" version="1">MVSFWPWKGDDNSPAGFEKTLSTLSAKIAQSTTRLDQQRQRARRFQALWTLYSTFAYLFYSIILALVVGWETWGVKEFAAIAGGPVLIYAVRTMITRIFDYRISRTQRHVDELNKQRDTTIEKLKVATKYNSTQQLLEKYGGESPKTTPKFKTDSPDSRRDASRSQQQQQQQGARTGLPPPPTANIRRPAPSSPQARSFPSPDAPSSPIPFQTPQQAQPSLPSSPSPFPSVQQMTDDPGFAPNAFSNSGQYIEQSHWYDRLLDVLLGEDETQPRNRMAMICSSCRLVNGQAPPGIKTLEELGRWKCGSCGAWNGEESETTQLLSSLRNNVGSDPALGESVIISDKDVRGSEPSDDEVVVTAWSGEEDNSHLEVTEPEDRTGEVSRPGSVRRSKRGRGKQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLE0</accession>
    <name>A0A9W9WLE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785912.1">
        <property type="nucleotide sequence ID" value="XM_056938535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLE0"/>
    <dbReference type="GeneID" id="81628785"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5469322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="85" mass="9622" checksum="7E3B510D26189F41" modified="2023-11-08" version="1">MCTRSPVRGEMTRRSKNLEPSAPHPPYSYPLTVIDESISDQCTKLDDLTRLRLIFKQQHHGKHSGSAEPSKAPQAERRPLRAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLM5</accession>
    <name>A0A9W9WLM5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_009295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786267.1">
        <property type="nucleotide sequence ID" value="XM_056938890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLM5"/>
    <dbReference type="GeneID" id="81629140"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF8">
        <property type="entry name" value="SUCRASE_FERREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5469677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="226" mass="26089" checksum="6A2C26CBB146C3AF" modified="2023-11-08" version="1" fragment="single">HHKHIKGFYSYVLVAPGRPDWKQKIEQERGSLMEAFVQTSAKSKRDHYMVSASNVPPPESDTEKTEIHEAIKILILPQFIYIDSVNQTVVPGLRQQDPNQHHWRADNTTMYARLCDSTMLSQAARRALIKRELERHLRPLGLDRDAEDSRPGGAGVFFFVSHVGGHKFLANVLIYRKQQQQMIWLARVRPEHCEEIVKHTILGGNVVHPETQLRGEFDRLRDLTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLN6</accession>
    <name>A0A9W9WLN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_009090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786062.1">
        <property type="nucleotide sequence ID" value="XM_056938685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLN6"/>
    <dbReference type="GeneID" id="81628935"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5469472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="112" mass="13440" checksum="BF6C11109119DD63" modified="2023-11-08" version="1">MADGKSGPFFSCDVRIEILPLVSLLPHILRNEKRRVIEWLHLRVNTIPGAHFLPRALSHARTPKARSRPANRTVKYYYYYYYYYYYYYYYYYYYPGTGSGYRSSSSKSSQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WRF1</accession>
    <name>A0A9W9WRF1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786682.1">
        <property type="nucleotide sequence ID" value="XM_056938300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WRF1"/>
    <dbReference type="GeneID" id="81628550"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5472136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="97" mass="11430" checksum="761A9FD9D59694C0" modified="2023-11-08" version="1">MKLCPSGRLSSTLKTMKNQGNCSYHFTEEELKSHAVDAEGWNEVRDFFDRIEDLVKRDGWTHPETFDVAFDFFCDLPKLGLRRMKGREREIFDKHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WT46</accession>
    <name>A0A9W9WT46_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786793.1">
        <property type="nucleotide sequence ID" value="XM_056937701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WT46"/>
    <dbReference type="GeneID" id="81627951"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="49954" checksum="C75BA069C9FD1037" modified="2023-11-08" version="1">MTSPSSSDGSLTPPVEEPEFELHFEARERFLLRLQWYQPLSGLLSSQSHGIQDDYDYDYDYDYEDEDEDADKKDSTISFLKTFFKFLPVRGQVHLADDINHEHCQTDAQLRDFVEYIKTALLRPLLVVADQTPRVTATSPSSSVSPLDLQKAKRDEREKRKAPKREHSTSSQPGPVLKFGSATHQDKDLLSTKQACLQRDQHRCTITRQWGLSDTSQSEHGGSVSLDAVHIIPFGLGNFREDGRRRNAQTWKCLYRYFPNIEGFFHRDVPSPAHTEADHAGTASIEKNNPIQSAEFDVNRLDNLLTIDTTLRCEFSRFAFILEEESSSSPSRPRYQVVIFPERFTKWTFLGRMPKTVTFEANDANHSTSSRPHPFPNRELLAVHAALGNILHATGEGVAIEETMELYERETLHYLARDGSTDIGGRLSFTNLAALANQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WT80</accession>
    <name>A0A9W9WT80_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Serine/threonine-protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_008135</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786827.1">
        <property type="nucleotide sequence ID" value="XM_056937735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WT80"/>
    <dbReference type="GeneID" id="81627985"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07841">
        <property type="entry name" value="STKc_CDK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000097">
        <property type="entry name" value="Putative cyclin-dependent kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000670">
        <property type="entry name" value="Serine/threonine protein kinase (Kin28)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037770">
        <property type="entry name" value="CDK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="64"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="354"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="70"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5475069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="401" mass="44592" checksum="3DD0B872AE8971A1" modified="2023-11-08" version="1">MALSPFGSRSPAVTVASPNSALRLKAAAAAPQNASASTSTIIRSDLNPERELAEQLNDDIRRKYVKGKKLGEGTYAIVYLGNYRDDPSSLVAIKKIKVNAEYKDGLTMDAIREVKYLQELSHRNIIALHDVFSSKDQNLNLVLEFLPGGDLEMLIKDGDIHYGAADIKAWMGMLARGVWFCHENFVLHRDIKPNNLLIGADGEVKLADFGLARSFADPYLNMTHQVITRWYRPPELLFGARQYSGAVDVWSMGMVFAELLLRVPLLAGMSDLDQITKICEAFGTPTEENWPGVTQLPNYVTDKVVPLQGRDFFLRQFPTAGPVGADLLMSMCVLDPRKRATALQVLQHRWWTTEPRPTNNEDLPRKSGTKKMGNDLARVGGETDEGLFKNAARQLDFGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTC8</accession>
    <name>A0A9W9WTC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-octaprenyl-4-hydroxybenzoate carboxy-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786877.1">
        <property type="nucleotide sequence ID" value="XM_056937785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTC8"/>
    <dbReference type="GeneID" id="81628035"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046281">
        <property type="term" value="P:cinnamic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033494">
        <property type="term" value="P:ferulate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049383">
        <property type="entry name" value="UbiD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048304">
        <property type="entry name" value="UbiD_Rift_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="3-OCTAPRENYL-4-HYDROXYBENZOATE CARBOXY-LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108:SF17">
        <property type="entry name" value="FERULIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20695">
        <property type="entry name" value="UbiD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like Rift-related" evidence="1">
        <location>
            <begin position="155"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5475119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="313" mass="34090" checksum="0F08DE27606100C6" modified="2023-11-08" version="1">MAASNDINHTFSSADESVHDCVEALQKDKDLVEINDEIDLHLEAAAITRLVYETDDKAPLLSNTKGRGKERVYFAALGLKAACELQVVTVVVSRAIFKVFLIDPFIVTTGPVKQNSLLGDEIDLNALPAPMIHKSKDGKFVQTHGMHVVQSTDKERKDAPRALCFGRSRRYLASSMPIPDGINEADYVGAMTERALELVKNRLQDGGTLFLTEIDGEGPFGEMNGYVFPGDTHPWRVYTVNKITYRHDLILPISACGSLTNETHIMIGALAAAAIRKVCQLTGLSTTDTVGICHWCGLGSCGFQNLLSPEGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTV7</accession>
    <name>A0A9W9WTV7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787141.1">
        <property type="nucleotide sequence ID" value="XM_056938049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTV7"/>
    <dbReference type="GeneID" id="81628299"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF1">
        <property type="entry name" value="DUF1275 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5475383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28617" checksum="BEED1CA589FFE146" modified="2023-11-08" version="1">MPSETEALLGNGHSHPSPPRSRSRGFLRHLRDEIDPGRGDLLLLFCYVITGLLDSSAVFIWGSFVSMQTGNTVYFGLGLVGSDDTRWVKSGISIAGFCLGSLFFGLFHRTFSPRQRWVLCASFLIQLACVVVAAVIVTIFQPSRDERIHWLVSVPIALVAFQSSGQALASRVLKHSSLTSVVLTSIYCDLFSHPDLLTRKFFRNTEELRRLGAVLGLLLGVVLGGLWAKSSVGMMGALWTAAALKTVMVFAWLLWKKVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTX4</accession>
    <name>A0A9W9WTX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_007701</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787167.1">
        <property type="nucleotide sequence ID" value="XM_056937302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTX4"/>
    <dbReference type="GeneID" id="81627551"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5475414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="130" mass="14622" checksum="9588C18E7B2845CD" modified="2023-11-08" version="1">MGGPDPNRNSRVRFVRRSQTLKNKAQELAKTCNARVYLMVDHPKGSFVYKSDNNSAWLEHAKIIHVLARTVRRSLTASHDDSALLKCPSPGKIQVSRLDKLARYFASRLDQLRALEAIYENLTAQSAASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUC8</accession>
    <name>A0A9W9WUC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787442.1">
        <property type="nucleotide sequence ID" value="XM_056937577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUC8"/>
    <dbReference type="GeneID" id="81627826"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5475689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="396" mass="42406" checksum="8E06C5AE3A2A10DE" modified="2023-11-08" version="1">MSRLPRWPDLYHDRANVRCLLDHQMCLHHHQHTSPSNSTNVGAIAGGVVGGVVALVVILFLIWWFVVRKRRNAQGSEPEKDHTSAFNSAREARQSTQSIASTVLTRASNVIQIAYIPGVTNRSPPETPNTLVPPVPPLPGAHPDQHFFMPGDLRDSTWTTMTGHQSMSPTLRSSVATTVYRSDAIVSATPAQQIQRSRANIVSVHNGPGGSGPGDSTQPTPVMITPRDAPAVPTITSTQLAKASAFSQSNSSIVARQVVAKPVMVRGPSVKKKNGITNRSPKVDAAGGEPPAGAKSESSSQQLDQQSSTLNNIAFSDDDSSSANETRPTTSSNSTKLTVLTPPDEPPQSEGPFQDNASTHKRLSAIVIDPKRSSQHTDRSPPPRGASPFSDDNEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUV4</accession>
    <name>A0A9W9WUV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787692.1">
        <property type="nucleotide sequence ID" value="XM_056936893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUV4"/>
    <dbReference type="GeneID" id="81627142"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10568">
        <property type="entry name" value="SWIB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="263"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5477148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="490" mass="54678" checksum="F2FE921869477A09" modified="2023-11-08" version="1">MQPNYARGYPQGSMKSPAATRRAAGPAGAMPVPMPQHAMNPQYLAAQRTIPHPNDAALRRSRKPTDKNMPEGLDEIVIGDGVGQYNNLRDLEKRLDAAIVRKRLDIQDSISKTVKKYRTLRVWITNTVENQPWQGASGNPGSGRFKVRIEGRLLDDHNDPTVPEDEDESSKGDNEDGVRDSQGGSSQAGARKPSQRLSHFFKSITVDFDKSANNAGEVKPVAWNKPQASGNSTTPSNAEFDSIQFSRSSQENVNVTISLVRDETPERYKLSKELSEVLDVEEETRSGIVLGIWDYIRAMGLQEDEEKRQVRCDHRLRAIFGRDQMFFPQIPESIGPHTSPMDPIKLPYTIRVDEDFHKSPTPTIYDIQVAVEDPLRQKMMALTQNPQYTAGLRQIAALDDQVALIIQALTHSRARHAFYKALGNDPATFLRRWTNSQRRDLEMIIGDANGVGDGSGPEFRRGGPESAWETPVAKEAVRYMLAKPEAAAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUV7</accession>
    <name>A0A9W9WUV7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein SOF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_007290</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787690.1">
        <property type="nucleotide sequence ID" value="XM_056936891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUV7"/>
    <dbReference type="GeneID" id="81627140"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000657">
        <property type="entry name" value="U3 small nucleolar RNA associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000743">
        <property type="entry name" value="U3 small nucleolar RNA associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="105"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="279"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="9">
        <location>
            <begin position="355"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5477146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="447" mass="50523" checksum="0E593B30C95A3F2E" modified="2023-11-08" version="1">MKIKALSRPTASQQAPGSSTVRQARNLDPSQHPFERAREYTRALNAVKMERMFAAPFLGQMGDGHVDGVYTMAKDPGSLERFASGSGDGVVKVWDLTTREEVWNTQGHENIIKGLCWTQERKLLSCASDKTIKLWDPYNSTPEAPPLASYLGSSAFTGLSQHRSIPSFAASSSVISIYDLSRPSSTPSQTLHWPTSVDTITSIAFNQTETSILASTAIDRSIIMYDLRTSSPVQKLVLNLASNAIAWNPMEAFNFAVANEDHNAYIFDMRKMDRALNVLKDHVAAVMDVEFSPTGEDLVTASYDRTVRLWKRNRGHSRDIYHTKRMQRVFSAKFTPDNKYVLSGSDDGNVRLWRANASDRSGIQSARQRTKLEYDQALIKRYGHMPEIRRIKRQRHLPKPIKKAGEIKREELGAIKRREENVRKHTAKANLKGRKSEREKMILAREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV03</accession>
    <name>A0A9W9WV03_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787769.1">
        <property type="nucleotide sequence ID" value="XM_056936970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV03"/>
    <dbReference type="GeneID" id="81627219"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5477225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="183" mass="19479" checksum="3FA83769E9A9D201" modified="2023-11-08" version="1">MGWFEAPSSNSKSSSSGGGYYVRRRGSPTRSHKGHSSSSSHKGFSTYHARHSAPSIFGFGRSTTGRSTSPSVFSSYSSSSRRARPREGFVQRMIYSAKKLLRDIWRYMRQHPVKVFFMVIVPLLTSGVLPKLLAMVGLRLPHGVASALGASSAGHGYGGMSGGAGGGLSEGMNGLLSLAKMFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV73</accession>
    <name>A0A9W9WV73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_007304</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787704.1">
        <property type="nucleotide sequence ID" value="XM_056936905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV73"/>
    <dbReference type="GeneID" id="81627154"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000040">
        <property type="entry name" value="L-serine dehydratase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="11"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5477160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="377" mass="40234" checksum="BB4252A2D15153E9" modified="2023-11-08" version="1">MSSSDKKPWIETPLIESSTLSKHAGCRIFLKLELLQPSGSFKSRGIGNLILSELQKNSNKGKTVHFFSSSGGNAGLAAVHAARDLGCPCTVIVPHSTKPMMIAKLRDAGASDVIQHGASWFEADSYLRREFIENQVVSDSGSGQESADAGLRRDSVNVYVPPFDHPLIWEGAASMVEEMARQLPPRRSDKEGASFPADVVVCSVGGGGLFNGVVEGIEQHLKRTTSMMSGDTARRHQPVRVLAVETKGADSLAYSLRQGKLSSLTEITSQATSLGALQVAQKTFTNASSPPYGIEVISVVGSDAEAAKGSLRLADETRLQVELACGIGLEVATGQRLRKAIPDLKPETRVVVIVCGGSNITSEMLAEYRAKLQGGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV98</accession>
    <name>A0A9W9WV98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_007296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787696.1">
        <property type="nucleotide sequence ID" value="XM_056936897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV98"/>
    <dbReference type="GeneID" id="81627146"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5477152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="71" mass="7730" checksum="714CF7E0864B157D" modified="2023-11-08" version="1">MLQRMQTRRPIVEGSRMLRAAVLDFVEDAPSSLIVGCLLSDEESAFSKTQGNGTSVGVSKSHSQLLDEFAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVB3</accession>
    <name>A0A9W9WVB3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_007558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787958.1">
        <property type="nucleotide sequence ID" value="XM_056937159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVB3"/>
    <dbReference type="GeneID" id="81627408"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40636">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40636:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5477414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="89" mass="8293" checksum="7EB9DDC31DD26609" modified="2023-11-08" version="1">MPINTSSQDSGVTGAAKFVTSTLGNTVGGVARTAGGVTGAAARGVGDTITSATGSAGQPVGDAIGSAGTGIEDGTKKVAGGVENAGQWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WWE1</accession>
    <name>A0A9W9WWE1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP-binding cassette sub-family D member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_007655</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788055.1">
        <property type="nucleotide sequence ID" value="XM_056937256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WWE1"/>
    <dbReference type="GeneID" id="81627505"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="176"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="531"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="796"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="814"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5477511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="828" mass="92985" checksum="C127A85E93D9CD95" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1T1</accession>
    <name>A0A9W9X1T1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_006730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788266.1">
        <property type="nucleotide sequence ID" value="XM_056936331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1T1"/>
    <dbReference type="GeneID" id="81626580"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5480836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="123" mass="13455" checksum="68C32F0AFFFA01CA" modified="2023-11-08" version="1">MAAAIKAINAKIRSNKVLDYVCSTHFWGPVSNFGIPIAAVMDTQKDPEIISGPMTAALVVYAATFMRYSLAVTPKNYLLFACHLTNFGAQTTQGYRYLSYWKWGGREAQLAEKAKEGALAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2G4</accession>
    <name>A0A9W9X2G4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_007079</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788615.1">
        <property type="nucleotide sequence ID" value="XM_056936680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2G4"/>
    <dbReference type="GeneID" id="81626929"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF6">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5481185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="287" mass="30898" checksum="A2565955B4106E89" modified="2023-11-08" version="1">MASPKYTWLITGCSSGFGLSLTRAAQAGGHRVIATSREPSRTPDLVAEIEGNGGKWVQLDVDSPQSGEVIAELEKGGDHIDVLVNNAGYSIHAPVETFTEEEIRSQMETMFFSPLRLIRAVLPYMRQRRAGVVVNMSSGASLDGIPTMSVYAGAKAGLDALTRILAKEVAPFNIRTLTVILGTFNTNMQNSAIFGKTPFPDDYNGTITQQMQHFLASGKLVPNGDKDKAMQALYQVIVGEGVGAGHEAEKLLPLGSDMTPRLQGAREYLGHALEVFDSVTNSVDVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3C2</accession>
    <name>A0A9W9X3C2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoprotein TPR/MLP1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_006422</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788948.1">
        <property type="nucleotide sequence ID" value="XM_056936024.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81626273"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057974">
        <property type="entry name" value="NUA/TPR/MLP1-2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012929">
        <property type="entry name" value="Nucleoprot-TPR/MLP1-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057577">
        <property type="entry name" value="Nucleoprot-TPR/MLP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25481">
        <property type="entry name" value="Nucleoprot-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25785">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07926">
        <property type="entry name" value="TPR_MLP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoprotein TPR/MPL1" evidence="7">
        <location>
            <begin position="183"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="NUA/TPR/MLP1-2-like" evidence="8">
        <location>
            <begin position="484"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoprotein TPR/MLP1-2" evidence="6">
        <location>
            <begin position="1068"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="362"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="991"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1501"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1587"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1771"/>
            <end position="2015"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="48"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="415"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="566"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="693"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="911"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1119"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1315"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1644"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="382"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1506"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1785"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1800"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1828"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1851"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1892"/>
            <end position="1902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1909"/>
            <end position="1932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1933"/>
            <end position="1949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1950"/>
            <end position="1960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="2003"/>
            <end position="2015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5482976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2015" mass="223904" checksum="82F7FA1D7B1D2583" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X4S9</accession>
    <name>A0A9W9X4S9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000007">
        <property type="protein sequence ID" value="KAJ5483826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056935628.1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
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        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5483826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="238" mass="26375" checksum="976C19079EE17F0E" modified="2023-11-08" version="1">MKTSDERNPFDATVACMLSIFTLGYFSIFLCQFIIFRFPATQEYIPMALSMIAFGSGVILWSLCVSSHQAFNVFEVRTAQEQKNITWCGLLFLIWTAALPTIVILFPAQPLLQLGYVIVFTIIALGNLPEYAAADKTVTETPPPRLPIHMICVVLLALVPTVHALAEPVTTSSSLATAFGRFVLSSTLGAAVYLFEPFEKIIVTSNWNPSLHIMHLILVFSLISYSRVVFDEVASRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X4X8</accession>
    <name>A0A9W9X4X8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789272.1">
        <property type="nucleotide sequence ID" value="XM_056935400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X4X8"/>
    <dbReference type="GeneID" id="81625649"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10206">
        <property type="entry name" value="ASKHA_NBD_Arp8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000201">
        <property type="entry name" value="Actin-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000232">
        <property type="entry name" value="Actin-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="546"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5484002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="710" mass="79992" checksum="4847DBC8A8A6D4A3" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5X3</accession>
    <name>A0A9W9X5X3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_005031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789827.1">
        <property type="nucleotide sequence ID" value="XM_056934633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5X3"/>
    <dbReference type="GeneID" id="81624882"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5485043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="195" mass="21347" checksum="D7703A8D02524958" modified="2023-11-08" version="1">MHIKLGAGLLHRHDTLQDGTAMFHEVQSLESDICVPKALSSIGMDNIAPNSSFVNQNGLFQAFEYSASGEATQIDAAFASDLAEFLKAHNFLEKRISIIPNPPGKEDFIEFTHPSGRGTISVPLRLISEQEIETSEPVITGWSFHINEHGVVECKGNNVCTSMNSGNHKVFQDSKPYTEHVVKVTPQLDAAAKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6A3</accession>
    <name>A0A9W9X6A3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-3-dihydroxybenzoic acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_004854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789650.1">
        <property type="nucleotide sequence ID" value="XM_056934456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6A3"/>
    <dbReference type="GeneID" id="81624705"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF31">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="41"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5484866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="353" mass="40185" checksum="9EDA4BF20EEB3601" modified="2023-11-08" version="1">MFGKISLEEAYERPNMEEKSMREARLYIAPHDRARYMRQIGDITNERLKLSDAHGIGYTIVSLTVPGIQGITDKAEAERVATETNDWVASEIKSHRDRLGAFACLSMHDPSQAATELRRCVKELGFHGALLCNFQHAGPDGETYLFYDQPEYDVFWQALTELDVPLYIHPSAPTGVVYEKLYEQRPSLIGPPLSFANDVSLHLLGLISNGVFDRFPKLKIIVGHQGEHIPFDFWRIDHWFEDIKRPIAQEEGRAMAQKNIYHYFKENIWLTTSGHFSTATLKYVVNEIGADRMLFSVDYPYETIEAGCGWWDNDRNAIVEAVGGLDNYRAIGRDNAKKLLKLGDFHDSEAPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6H2</accession>
    <name>A0A9W9X6H2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790039.1">
        <property type="nucleotide sequence ID" value="XM_056934845.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81625094"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF9">
        <property type="entry name" value="NACHT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G01760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="326"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="2068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5485255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="2068" mass="234427" checksum="A48257B099F836D6" modified="2023-11-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6I6</accession>
    <name>A0A9W9X6I6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">propanoyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Propanoyl-CoA C-acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_005231</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.176" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790027.1">
        <property type="nucleotide sequence ID" value="XM_056934833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6I6"/>
    <dbReference type="GeneID" id="81625082"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000016">
        <property type="entry name" value="Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006102">
        <property type="entry name" value="PRK08256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="11"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="262"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5485243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="458" mass="49158" checksum="36B6E5857A1C2DE3" modified="2023-11-08" version="1">MVKKQTSPAYVLGVGMTKFIKPRGKVDYNELGYEAGIKAMLDAKITYDDVDQGVACYVYGDSTCGQRVFYQFGLTNIPIYNVNNNCSTGSTGLAMARTMVSHGAADCVLVVGFEKMNPGSLQSMYNDRANPTGLFGTMMAETRGVTNAPGAAQMFGNAGREYKEKYGATNEDFAEIARINHEHSKRNPYSQFQDEYTLEQIMKAPMIHEPLTKLQCCPTSDGGAAAVVVSQEFLDARPHLKSQAIIIAGQCLATDSDSVYSKSSIDLMGFGMSRHAARTAAAEAGINIKDVKVCELHDCFSANEMITIDALELCEPGKAHEMVRRGDITYGGKMVINPSGGLISKGHPLGATGIAQCAELVWHLRGWANNRLVKGTDAALQHNLGLGGAVVVTVYKRADGKAAEAVPSDAVGKINGLGYNPAVEARGFTAEQAKSVVSKKHSSDWAVADAQERVLARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6J2</accession>
    <name>A0A9W9X6J2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome b-c1 complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789981.1">
        <property type="nucleotide sequence ID" value="XM_056934787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6J2"/>
    <dbReference type="GeneID" id="81625036"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019182">
        <property type="entry name" value="Cytochrome_b-c1_su10_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254:SF1">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09796">
        <property type="entry name" value="QCR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="9584" checksum="09D3D22A90CBA6D7" modified="2023-11-08" version="1">MFTPTIRRAAAKATSSAFAPKIAIPPKIAGFTIPSAIQAGSLAASFGVFAGTAALFMFGEIPRVRRDILQKIPGLDSYYDRPIAPEDNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6L5</accession>
    <name>A0A9W9X6L5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_005955</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789429.1">
        <property type="nucleotide sequence ID" value="XM_056935557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6L5"/>
    <dbReference type="GeneID" id="81625806"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011553">
        <property type="entry name" value="Sec62_asco"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00869">
        <property type="entry name" value="sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="290"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="68"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="352"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="68"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5484159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="409" mass="45167" checksum="8E7E3F165BA2956F" modified="2023-11-08" version="1">MAAPGQPSPQQMAQMAAMQQQFAAEAAKRGLTPEQFAQQQRDQLAADAAKQGLTPEQYIAQLRMRAFQAHQQQMEAQRQAQAQGQGSPQPGQPQQPGQPGQPGPQAQPQAQQPAQAQQQTHQVPVQPGQPADPKAVALANFLRSQNLKTRTCILDGQRKDMFKVKRAIRAIESPAYAKVASKKNSILPPVTDRASAENVFKLLPLSLLALRVSKVDPHEGHNHAKPKNRVKGQWTVKIEQHQDVDPMMHYVWLYEGPQWKQKAMAAAVVAGIFAVVLFPLWPVMLRQGVWYLSVGMMGLLGLFFAMSIFRLILFCITVFAVPPGLWLFPNLFEDVGFFDSFKPLWGWQETKKKKSKKSKTAADATATKSAEKSLESHPAATTTSAETTATSTATPVKRDLAPRVEEVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7N3</accession>
    <name>A0A9W9X7N3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
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            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">IBT 30728</strain>
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    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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            <strain evidence="8">IBT 30728</strain>
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    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056933212.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81623461"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="437"/>
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        <location>
            <begin position="446"/>
            <end position="561"/>
        </location>
    </feature>
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        <location>
            <begin position="450"/>
            <end position="531"/>
        </location>
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            <begin position="84"/>
            <end position="110"/>
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        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5488720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="587" mass="65361" checksum="FAECD5F1433D13AF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCB7</accession>
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            <fullName evidence="6">Microcystin LR degradation protein MlrC</fullName>
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        <name evidence="4" type="ORF">N7539_003426</name>
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        <name type="scientific">Penicillium diatomitis</name>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="32"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Microcystin LR degradation protein MlrC C-terminal" evidence="2">
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            <begin position="332"/>
            <end position="502"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5488536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="58407" checksum="7B1FA39F6CF480FC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCR5</accession>
    <name>A0A9W9XCR5_9EURO</name>
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        <recommendedName>
            <fullName evidence="2">MHYT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_003772</name>
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    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
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            <taxon>Ascomycota</taxon>
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            <taxon>Eurotiomycetes</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488882.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152:SF1">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
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            <end position="72"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="141"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="2">
        <location>
            <begin position="16"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5488882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="797" mass="88298" checksum="2F2A796FD9902C25" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XD03</accession>
    <name>A0A9W9XD03_9EURO</name>
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        <recommendedName>
            <fullName evidence="7">Ribosome biogenesis protein Urb1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_004025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
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        </lineage>
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    <reference evidence="5" key="1">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489135.1"/>
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        <property type="nucleotide sequence ID" value="XM_056933627.1"/>
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    <dbReference type="GeneID" id="81623876"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059018">
        <property type="entry name" value="HEAT_URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26140">
        <property type="entry name" value="HEAT_URB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 N-terminal" evidence="2">
        <location>
            <begin position="97"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 central HEAT repeat" evidence="4">
        <location>
            <begin position="634"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 C-terminal" evidence="3">
        <location>
            <begin position="880"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5489135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1126" mass="126698" checksum="3171F51A87FDC942" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDM6</accession>
    <name>A0A9W9XDM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_004340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791483.1">
        <property type="nucleotide sequence ID" value="XM_056933942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDM6"/>
    <dbReference type="GeneID" id="81624191"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07380">
        <property type="entry name" value="MPP_CWF19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="3">
        <location>
            <begin position="315"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="2">
        <location>
            <begin position="528"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5489450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="584" mass="64712" checksum="A83CEEB94A4A4947" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDY3</accession>
    <name>A0A9W9XDY3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA stability protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_004495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the endosulfine family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791638.1">
        <property type="nucleotide sequence ID" value="XM_056934097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDY3"/>
    <dbReference type="GeneID" id="81624346"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF6">
        <property type="entry name" value="ENDOSULFINE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5489605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="174" mass="18336" checksum="382142D84CA5FF69" modified="2023-11-08" version="1">MNPHQQNKVDISSMTPDEQRLLRMYGKMPTKKDLLQNKLKERKYFDSGDYALSKAGKASDVGVTSIGSRHPVPENIPHLTATSPGANNPGGNGGSTAGIGQQMPGSISGHPGSIGFQSRSPVKEGGSFLHRGSSLSEESSTMDTEGGDNNTVKNQGEESSVSPPPGRQGVPIHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE00</accession>
    <name>A0A9W9XE00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL32m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_004481</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791624.1">
        <property type="nucleotide sequence ID" value="XM_056934083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XE00"/>
    <dbReference type="GeneID" id="81624332"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051991">
        <property type="entry name" value="Mitoribosomal_protein_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL32M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040927025" description="Large ribosomal subunit protein bL32m" evidence="8">
        <location>
            <begin position="29"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5489591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="97" mass="10649" checksum="A65EBEF1C5778294" modified="2023-11-08" version="1">MPQLPPLGFLSTAAFALPISITIPPLLADLWESVLRAVPKKKTSHMKKRHRQMAGKALKDVQSLNKCPGCGQVKRAHVLCPHCVKDIKQSWKSAQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE11</accession>
    <name>A0A9W9XE11_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_004018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791161.1">
        <property type="nucleotide sequence ID" value="XM_056933620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XE11"/>
    <dbReference type="GeneID" id="81623869"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.780:FF:000002">
        <property type="entry name" value="Probable vacuolar protein sorting-associated protein 16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="3">
        <location>
            <begin position="503"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5489128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="829" mass="93517" checksum="8DBE1FA71A692990" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE44</accession>
    <name>A0A9W9XE44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_004595</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791738.1">
        <property type="nucleotide sequence ID" value="XM_056934197.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81624446"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000004">
        <property type="entry name" value="E3 ubiquitin-protein ligase HUWE1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="13">
        <location>
            <begin position="3704"/>
            <end position="4040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="267"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="715"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1158"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1529"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1616"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2000"/>
            <end position="2049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2075"/>
            <end position="2123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2358"/>
            <end position="2538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2686"/>
            <end position="2716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2868"/>
            <end position="2951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="3021"/>
            <end position="3045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="3100"/>
            <end position="3124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="3326"/>
            <end position="3409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1167"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1183"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1645"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2008"/>
            <end position="2021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2029"/>
            <end position="2049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2406"/>
            <end position="2452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2468"/>
            <end position="2501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2506"/>
            <end position="2517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2518"/>
            <end position="2538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2868"/>
            <end position="2914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="2924"/>
            <end position="2938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="3022"/>
            <end position="3034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="3105"/>
            <end position="3121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="3326"/>
            <end position="3340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="3346"/>
            <end position="3363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="3383"/>
            <end position="3400"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="4007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5489705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="4040" mass="451143" checksum="45A39FC8B4A83D16" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XES1</accession>
    <name>A0A9W9XES1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791978.1">
        <property type="nucleotide sequence ID" value="XM_056932019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XES1"/>
    <dbReference type="GeneID" id="81622268"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5490849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="192" mass="20727" checksum="ED64BDD26BE2C1AF" modified="2023-11-08" version="1">MSTTCPNLFFAGGFVILYEDKVPLVARSADNAKYLVVDRAASERTREMRQKRPALNVRKHGICTKDRTGCAKLRVVSNRAFSTRARSRVQGRFLAVERGRPASKVDSMTGVYGELRPAQRSGLGNDNAAGEGTTRDQGVQGTFFGGGATGHCEGGNEEIGCMGALSRGELIESNAARLRDGLSEAEVRPYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XES6</accession>
    <name>A0A9W9XES6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_002353</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791915.1">
        <property type="nucleotide sequence ID" value="XM_056931956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XES6"/>
    <dbReference type="GeneID" id="81622205"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="69"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5490786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="320" mass="34961" checksum="7C2721FCA3A83E9D" modified="2023-11-08" version="1">MRFPRKPKIIPPPPGLDQTAWCSMHAAELRRSLESLLPTNPVPANVHEQSQPEQRAVAPFIFEATNTDTTTTNYNLTPPSSKSVERASRPCLSDESTESGPAKERPQQASSTLLSTLASEVAQIFQNPESAVQLVVQQNVSVFYGGSTLPSYLLKVWTSSAACGSLLNLRNATLLQQTLHDTLGIASDRGAVLFMPVPEVNIGTICSTAQSVFGRQEQVGAQRSGLFRTLSRGMSRRLKRTSDTTGPLIVSGATPTHIRLYEADRKRSSENAAVVDAEQKEYDGPKTRESLMSILERLRRAKKSKVKQESEGDTCHGGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF47</accession>
    <name>A0A9W9XF47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA methyltransferase FtsJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792234.1">
        <property type="nucleotide sequence ID" value="XM_056932275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF47"/>
    <dbReference type="GeneID" id="81622524"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="2">
        <location>
            <begin position="93"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5491105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="353" mass="40447" checksum="799F3F6BD8DEE12D" modified="2023-11-08" version="1">MESDKHKPSGEDQPSGEDKQSKEAKATNEDYDVIRNYLSPRSSIFQDLIETQDKVKNDPAADEHFKRLKESIMKVSQDKQLGFFKMGARICSEMQQKEDIIPRPQRTVQLKAFDICMAPGAFSHVILNVNRFAEIRALTLPKQDGGHELLLPNWQTDRRFKVHFLDVTMLPAAMGFPDLIPTDHPQAVKFSNEFHYKNETFDIVFCDGAVLHTHDRGQETPGEAVRLSSAQLVLGLQNLKSAGTFKFARVSLFKPTVSHRNRSSFYLIAKNVETTSPEAKKFLRSHRLKWLRKTVESFDLKMPDIEPQEEEEPMESIISAIGDELIRLAEPLWKIQILAMKQLFLKPKPTQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFB7</accession>
    <name>A0A9W9XFB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_002638</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792200.1">
        <property type="nucleotide sequence ID" value="XM_056932241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFB7"/>
    <dbReference type="GeneID" id="81622490"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF149">
        <property type="entry name" value="UBID FAMILY DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="29"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5491071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="392" mass="44112" checksum="37B28067276CA3E2" modified="2023-11-08" version="1">MSGLGGDFGRQFERETWTLYGVGVLGAVLRFVARARRLGIRNLQIDDYLMFFAVFWYTVLSVALTSVATGGGSNLLTPEDLVNMTDAERKDRVRGSKWVFVSEHAFILCIWSLKACMLVIYSRITEGLKQRKWINYIAIYVALGFVGTELSLFLICRPITDYWAVPTPNPQCSNYQYYEIVQGCFSISADIFMLLVAIPMLMQVRVPTKQKLILLILFGMGIFVIVAAVLNKVYCLVPALISYVYMNWYFREATVAILVTNLPLVWSLLRDVFPALKSWTGGSKRGTDRYKSGPWTSKNSRPYGPHSQLRSGDFDMNTIQHKTTVTPQKTADVSDISIAASDDRDVSSDDGSARALRIRQDITVTIEHDARPADGQAQVAQDVRKPRERAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFH5</accession>
    <name>A0A9W9XFH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhamnolipids biosynthesis 3-oxoacyl- reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_002550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792112.1">
        <property type="nucleotide sequence ID" value="XM_056932153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFH5"/>
    <dbReference type="GeneID" id="81622402"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF12">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_1G14540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5490983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="281" mass="29238" checksum="C84D84B22AB17706" modified="2023-11-08" version="1">MSAADQVRLSNFSTIFSLEGKVAVVTGGSRGLGLHAASGLLQAGCSKVYITSRKKNACDEAVAALNALPNKRPGAQAISVPADSSRVEEIERLAAEISKTTDHVDILFANAGATWGEKFDTHPDKMFSKVMDLNVKSVFYTIQKLAPLLQAKATLEDPSRVIITASVAGIGIGSVGENATPSYSASKAAAIHLAKNLAVELGPRHILTNAIAPGFYPSKMASGLINAKGGMKQMEEYSPNGRLGRPEDIAGLVVFLGSRAASHLNGAVIATDGGAVLKGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFM9</accession>
    <name>A0A9W9XFM9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002834</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in cellulose degradation. Shows hydrolytic activity against several glycosidic compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792396.1">
        <property type="nucleotide sequence ID" value="XM_056932437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFM9"/>
    <dbReference type="GeneID" id="81622686"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080079">
        <property type="term" value="F:cellobiose glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000011">
        <property type="entry name" value="Cytosolic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5491267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="483" mass="54407" checksum="C976941BC49087F8" modified="2023-11-08" version="1">MGSIEHSHLPADFLWGFATASYQIEGAVDEDGRGPSIWDTFCKIPGKIAGGGSGEIACDSYHRTHEDIELLKTCGAKAYRFSLSWSRIIPLGGRNDPVNKKGLQFYVKFVDDLLAAGIIPMVTLFHWDLPDELDKRYGGFLNKEEFVADYANYARIVFQALSPKVKYWVTFNEPWCSSVLGYNNGSFAPGHTSDRTKSPVGDSSTEPWIVGHSILVAHGAAVKIYREEFKERDGGEIGITLNGDWAEPWDPENPADVEACDRKIEFAISWFADPIYHGRYPDSMIKQLGNRLPTWTAEDIALVQGSNDFYGMNHYCANFIRAKTGEPELDDIAGNLELLLEDKNGVSVGPITQSPWLRPSAIGFRKLLKWLSDRYGYPKIYVTENGTSVLGESDMPVNELLNDEFRVQYFTDYINAMADAYTLDGVNVRAYMAWSLMDNFEWAEGYETRFGVTYVDYENDQKRIPKKSAKSIGQIFDRLIQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFP3</accession>
    <name>A0A9W9XFP3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_002655</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792217.1">
        <property type="nucleotide sequence ID" value="XM_056932258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFP3"/>
    <dbReference type="GeneID" id="81622507"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF46">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="13"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5491088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="511" mass="56698" checksum="3CDE88364F9D21FB" modified="2023-11-08" version="1">MAISSKRLYNWFISLVAASCMVLYGYDASVFNSIQGSKNWVEWFNNPNAATIGGINTAYTVGAIVGGFFFSGPIADYFGRKVGMATGCVLVIIATFMQTFAPYHGLACFMVGRVLIGLGQGIALTSGPIYIGELAPSEIRGQIMTFWQMFYSVGSFICFWIAYACTKHESTLGHWDWKMIIIFQLLVPVIILVLLPTIPGSPRWYIKRHNDIEKARAALRRVRDTEEEVEAEILQIREAIEYENEAISGTYSAIWKDKSIRKRMYLALVLNAGQQLTGQGSLNSYSTAIYKKIFEKASTIALINALNATFGIIFTLNAVWIVDRFGRKPLLILGGIGMGICMIISATVETQTPTLPNGAKSEPVGIAIVALLFIFILFYKPSWGATVWIWTSEVFSMNVRAQAVGMASQTQNVANTIFQQFFPIFLNNKGFYAFYFFAAINFVLAIFVFFLVPETKKVTLEEIDALFGGANHVIQGEGVLAHHKEVEAMQHQGSVSEKPGAVTVEDVEHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFV3</accession>
    <name>A0A9W9XFV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792598.1">
        <property type="nucleotide sequence ID" value="XM_056932639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFV3"/>
    <dbReference type="GeneID" id="81622888"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5491469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="215" mass="24748" checksum="E0625B1BE55B3BAB" modified="2023-11-08" version="1">MDPEMFMRDRQHFREKLLGWVRILSDESVSETAYVEIVAELNDMVRDIEILGQPPPLRTLQAEDFDLIDSTFPPTSENHGEEHDDPDGFEMIHPLAEADFGRLCSKDGAVRDTLSWAGELLRRRNAPFADIAVILDMLALHIGRLRLMRDKKDEDELQDGEGIGVDAYADEMDEMARVEHESRQQLPNEYLRAIWNRLYSCMDCNCDKCGLVARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGQ9</accession>
    <name>A0A9W9XGQ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar transporter STL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_003035</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792597.1">
        <property type="nucleotide sequence ID" value="XM_056932638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGQ9"/>
    <dbReference type="GeneID" id="81622887"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015793">
        <property type="term" value="P:glycerol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF55">
        <property type="entry name" value="SUGAR TRANSPORTER STL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="17"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="516"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5491468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="544" mass="59630" checksum="C624FA78A5A96B0C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGW9</accession>
    <name>A0A9W9XGW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="2">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_003125</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792687.1">
        <property type="nucleotide sequence ID" value="XM_056932728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGW9"/>
    <dbReference type="GeneID" id="81622977"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000014">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000004">
        <property type="entry name" value="Heat shock protein SSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5491558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="615" mass="66862" checksum="6EF4D07838EF275D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH43</accession>
    <name>A0A9W9XH43_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Formate dehydrogenase</fullName>
            <shortName evidence="6">FDH</shortName>
            <ecNumber evidence="2 6">1.17.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2 6"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792806.1">
        <property type="nucleotide sequence ID" value="XM_056932847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH43"/>
    <dbReference type="GeneID" id="81623096"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042183">
        <property type="term" value="P:formate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05302">
        <property type="entry name" value="FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000057">
        <property type="entry name" value="Formate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03210">
        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005750">
        <property type="entry name" value="PRK07574.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="7">
        <location>
            <begin position="175"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="220"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="276"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="357"/>
            <end position="360"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="6">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="6">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5491678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="408" mass="44837" checksum="A2F4942FCDC31DEA" modified="2023-11-08" version="1">MVFIRSLSRQLRRPASQVLSGSAFARKPVLGAFSQARTLTATANNQGKVLMVLYDGGEHAAQQPRMLGATENELGIRKWLEDNGHTLVTTSDKEGENSTFDKELVDAEVIITTPFHPGYLTAERLAKAKKLKLAVTAGIGSDHVDLNAANQTNGGITVAEVTGSNVVSVAEHVVMTILLLVRNFVPAHDQVRNGDWNVAAVAKNEFDLEGKVVGTVAVGRIGERVLRRLKPFDCKELLYYDYQPLSPEVEKEIGCRRVDNLEDMLAQCDVVTINCPLHEKTRGLFNKDLISKMKPGSWLVNTARGAIVVKEDVAEALKSGHLRGYGGDVWFPQPAPKDHPLRTAEHPWGGGNAMVPHMSGTSIDAQIRYAEGTKQILDSYFSGREDYRPQDLIVHKGEYATKAYGQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHJ0</accession>
    <name>A0A9W9XHJ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_001719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793353.1">
        <property type="nucleotide sequence ID" value="XM_056931322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHJ0"/>
    <dbReference type="GeneID" id="81621571"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01150">
        <property type="entry name" value="Main.1:_Beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="94"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5492973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="25855" checksum="1FFA5287A9DAB177" modified="2023-11-08" version="1">MPLTLHHMGVSQSERIVWLAEELGLDYQLVHHKRDPLLSPQSIKDLHPAGTAPVIVDDPSPVTHSRVVLAESCAIVDYIIAVYGQGHLALTPQDGAAYPHYLEWYHFANGTLQPAIMRLFIASNANPDPSSPIVAMTAQKKDHALSMVENRLAKTGAYLAGDALTAADIMTVFSLTTMRGFVPMEFDQTKHAHILSYLKRICERPAYKKAMELCEGKDFVPMVGPKIEPFNLGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI08</accession>
    <name>A0A9W9XI08_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">High osmolarity signaling protein SHO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">High osmolarity signaling protein sho1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7 8">Osmosensor SHO1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein BZZ1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_002093</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in endocytosis and trafficking to the vacuole. Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the BZZ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793727.1">
        <property type="nucleotide sequence ID" value="XM_056931696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XI08"/>
    <dbReference type="GeneID" id="81621945"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20824">
        <property type="entry name" value="C1_SpBZZ1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11912">
        <property type="entry name" value="SH3_Bzz1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000060">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000161">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000040">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035459">
        <property type="entry name" value="Bzz1_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF21">
        <property type="entry name" value="PROTEIN NERVOUS WRECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="F-BAR" evidence="17">
        <location>
            <begin position="8"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="16">
        <location>
            <begin position="407"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="577"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="683"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="477"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="524"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="632"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="535"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="561"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="654"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5493347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="741" mass="81322" checksum="13A30847FB826A0E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLA6</accession>
    <name>A0A9W9XLA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrolase YcaC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_000192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794089.1">
        <property type="nucleotide sequence ID" value="XM_056929796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLA6"/>
    <dbReference type="GeneID" id="81620045"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053152">
        <property type="entry name" value="Hydrolase_YcaC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559:SF3">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040883251" evidence="2">
        <location>
            <begin position="22"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="87"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5495076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="237" mass="25941" checksum="425EC9825F1E2E3A" modified="2023-11-08" version="1">MNFSEFIQTALLLAISVPAQAWNRLDKENAALLVNDHQVGLAQLVRDFGTNDFRNNMLAHSAIGNIFDLPTILTSSSDGGPNGLLLKEITEMHPNATFIRRQGEVNAWDNADFRKAVKALGKKQLIIGGIVTEVCTAFLALSLIDEGYEVFANTDASGTFDVKLAEDANRRMEKAGVTLMGFFAIVCDLMRDWRATPGLTEILPVIDQYQFAYGMAARHHAGAILNGTIAEVEKTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLN4</accession>
    <name>A0A9W9XLN4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAP family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_000437</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794334.1">
        <property type="nucleotide sequence ID" value="XM_056930041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLN4"/>
    <dbReference type="GeneID" id="81620290"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="338"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5495321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="42479" checksum="F478156BBE6AEAB3" modified="2023-11-08" version="1">MSGEDKSLSERIEFPAIPEEARSKISHVQEELERAELEQLRKSIPLFAPIFKKREEIISMPGVKSDFWARVFSTAPSEISEFILESDSEILAENLKNVVVERFEVDAEGNGEPRSLRFTFEFETENNEFFDNAKLVKEFYWRKHVQKTAKGKRRAWEGLVSDPVRINWKSADVDPTRGLLDAACDLFDAEKKKGGKRTDLPEYEALVKKLEIAEAEAMQGADIEDMEDLPEDEDDSPAGASFFSFFAYRGRDVSAEQNKEALKEDEERWAKIARGEEVPEDDDEEEEDDEEEEDFDLVDDLEEAEVFPGGEDLAIAIAEDLWTNALKYYAESFQPSFDFEDEFEELEDMDEDEDDVDDGEDQPPAKKARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLQ1</accession>
    <name>A0A9W9XLQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Periodic tryptophan protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_000417</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794314.1">
        <property type="nucleotide sequence ID" value="XM_056930021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLQ1"/>
    <dbReference type="GeneID" id="81620270"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000219">
        <property type="entry name" value="Periodic tryptophan protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000470">
        <property type="entry name" value="Periodic tryptophan protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001680">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit (Pwp2), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="191"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="334"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="376"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="462"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="511"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="8">
        <location>
            <begin position="751"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="627"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="873"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="643"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="874"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5495301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="898" mass="99376" checksum="1348A0CBB2C40695" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLQ5</accession>
    <name>A0A9W9XLQ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794364.1">
        <property type="nucleotide sequence ID" value="XM_056930071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLQ5"/>
    <dbReference type="GeneID" id="81620320"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="28578" checksum="8EBC6BC4F8B1AB03" modified="2023-11-08" version="1">MSSSSPTTLFPGVAVVTGAGGTGIGAAVVRAFAAAGCERIAITDVNETTLEQTKATISATYPRSQVFVHPGNFTDDHFAENFIRKVVENFGRVDYAVNCAGVLGQAVRSSEMSIDEFDRVNNINYRGCWLSSRAQLKQMLEQDALASHDPERPAQRGAIVNIASQLGLVSRPAAPAYCASKAAIIAMTRSDAVDHSQDGIRVNCVCPGVIETPMITGDPAVLEAIGPAVDIAPMKRMGKPAEVADAVLFLCSTHASFVQGHALGVDGGYVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLS4</accession>
    <name>A0A9W9XLS4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Phosphatidylinositol transfer protein SFH5</fullName>
            <shortName evidence="16">PITP SFH5</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">N7539_000354</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:38692"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Endoplasmic reticulum membrane</location>
            <topology evidence="2 16">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Microsome membrane</location>
            <topology evidence="16">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the SFH5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794251.1">
        <property type="nucleotide sequence ID" value="XM_056929958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLS4"/>
    <dbReference type="GeneID" id="81620207"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000017">
        <property type="entry name" value="Phosphatidylinositol transfer protein sfh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042938">
        <property type="entry name" value="Sfh5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0492">Microsome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="18">
        <location>
            <begin position="186"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="379"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ5495238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="448" mass="49102" checksum="EA8037534416042C" modified="2023-11-08" version="1">MADLNTTEQAPAAELVKRDEAVALAPEVLPASDQSAAAPAAAPTETVTPTEAEPQVVQPTEETPVEHCETVNDAAALPAAAAINPAAHVPDGATPQEPSVEEQPEYLTKIAGLTQFFEQLPQILTETGHQEMWGVVLKNHEDVPTVNVLIKFLRANEGNVQAAQDQLRKALEWRKEINPIALVESGRYSAAKYDGLGYLTTYEQDGRPLVFTWNIYGAVKDVKKTFGDSNEFVKWRAALMEMAVQDLKMKDATEVIDYDGKKDHYQMIQVHDYLHVKFLRMDPVVRAATKQTIEVFSTAYPELLREKFFVNVPSIMGWMFSAMKLFLSRNTTRKFHPIANGANLAREFPSAIGDQIPKTYGGKGAELREGARTVQLVEDEVEPEAAQSESQPTQASSDVVAPAVPEKVEQPVAEEATAPVSAQPAMPEVLTKDAAVTEEEKPVSEVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM20</accession>
    <name>A0A9W9XM20_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794073.1">
        <property type="nucleotide sequence ID" value="XM_056929780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XM20"/>
    <dbReference type="GeneID" id="81620029"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="315" mass="33112" checksum="BDFCE8C840D65030" modified="2023-11-08" version="1">MASNKDNCPSSSPLSSSGASGTSGTKRKRPTDGASFSSFSSGSASKKTKVNSSSDVPVPAPTASPCPYTDTFFLGMATAIRQTFPLADFARHYRCSTDDVADALFAVVMQPLCQPPSEDLSVADACQIQIADWRELKAQVPGTCIPPQEPQVACSVDEDLQSGSSGSNLAVTAPSLPSSSRAVTPEGSPSPVAACGAGSQSLPEPVRCDRIPVQRRRWVNGRSVLTGCPGGSDDESSGLAGQLGVMTDAEFEQLVANGQLKALLKDDEEEEADQVGCANPGLVRRRPPGGKWIFPSRWRDKEYSRPVKQVSDSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMJ7</accession>
    <name>A0A9W9XMJ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_000852</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794749.1">
        <property type="nucleotide sequence ID" value="XM_056930456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMJ7"/>
    <dbReference type="GeneID" id="81620705"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15735">
        <property type="entry name" value="FYVE_spVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21385">
        <property type="entry name" value="GAT_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16979">
        <property type="entry name" value="VHS_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1940:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000031">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000161">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049425">
        <property type="entry name" value="Vps27_GAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21356">
        <property type="entry name" value="Vps27_GAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="15">
        <location>
            <begin position="24"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="14">
        <location>
            <begin position="165"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="231"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="276"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="327"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="513"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5495736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="667" mass="72150" checksum="2F0E2D23FC5C91F0" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMQ0</accession>
    <name>A0A9W9XMQ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UNC93-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_000927</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794824.1">
        <property type="nucleotide sequence ID" value="XM_056930531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMQ0"/>
    <dbReference type="GeneID" id="81620780"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06178">
        <property type="entry name" value="MFS_unc93-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="104"/>
        </location>
    </feature>
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            <end position="132"/>
        </location>
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            <end position="161"/>
        </location>
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            <end position="230"/>
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            <end position="282"/>
        </location>
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            <end position="320"/>
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            <end position="351"/>
        </location>
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            <end position="404"/>
        </location>
    </feature>
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        <location>
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            <end position="466"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5495811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="504" mass="55473" checksum="9B5817E49CBFD007" modified="2023-11-08" version="1">MAEAEPKAPTTEVGPSSSFTDDVPRPRGWMYKRIGSGKVNLGWYASPKFQLGMVAFVCFLCPGMFNALSGLGGGGKADAHLADDMNTALYSTFAVVGFCAGTIVNRLGVRIALSFGGIGYCLYAISLLVSVHKYVPGFNIFAGAFLGVCAGLLWTAQGTIMMSYPTERSKGRYFAWFWGIFNVGACLGSLIPLGQNHSVKTNSTVTDGTYIAFIVLMFAGACLALFICDADKVVREDGSKVILMKSPSWKTEIYGLWETIKAEPFIILLFPMFWSSNWFYTYQQNAINGAYFDTRTKSLNGFLYWFAQIVAATIIGPLLDSNRVRRSVRAKIAFAVLFILTMVIWGGGYAWQKRYTRESVSKDAIKAGTFTPWDWTTPGYVGPMFLYFFYGLYDAVWQGVVYWFMGALGNSGRRLANLAGFYKGLQSAGSAVMWSLDSKKTPFMNEFASNWGILAGSLVVALPVVLMRIRDTIPIEEDLKGTDETIEDVLPPGTIAEKRVHGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN08</accession>
    <name>A0A9W9XN08_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_001124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795021.1">
        <property type="nucleotide sequence ID" value="XM_056930728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN08"/>
    <dbReference type="GeneID" id="81620977"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5496008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="67" mass="7591" checksum="6F979DAD9AE5E72D" modified="2023-11-08" version="1">MTRHGRSAFNLSLPLWATLEIAWEKTSYRDRSGTDSSFTQLTLSTDEGLDKRGSLLTTDEDPNGEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN62</accession>
    <name>A0A9W9XN62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit OST5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_001199</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OST5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795096.1">
        <property type="nucleotide sequence ID" value="XM_056930803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN62"/>
    <dbReference type="GeneID" id="81621052"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007915">
        <property type="entry name" value="TMEM258/Ost5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05251">
        <property type="entry name" value="Ost5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5496083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="77" mass="8087" checksum="0D5C30B57D9A21FF" modified="2023-11-08" version="1">MSLIEAWDAASATPFHPFVSKDSQFAVGFNLLMIAIILTGLFGLNRSFLSLASLGVPASVLFGFGAVFTICAVGVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XNW5</accession>
    <name>A0A9W9XNW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase apdG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_001021</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794918.1">
        <property type="nucleotide sequence ID" value="XM_056930625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XNW5"/>
    <dbReference type="GeneID" id="81620874"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF15">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE APDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="26"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="159"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="267"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5495905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="441" mass="48359" checksum="A4601E2B1A7D8B27" modified="2023-11-08" version="1">MADNSPNPVPFSEPPYLRGLPSPYITDAHREFQKRCRRFMWENLIQHAMEWEKLGTVPEHVFHTFCKYNMLLPNMPAPLPVDWLKRLGIDDILGVKVEDWDYIYTGIYCDELNRSGLSGPGGSLNAGFAFGIPPIVKFGSKELQERFLPDLLTGRKRACIAITEPEAGSDVANIVTTATKSADGKYYIINGTKKWITNGIWSDYATMAVRTGGPGPSGLSVLVVPLKNHPGVTMRRLKVAGQVAGGTTYIELDDVKVPVSNLIGKEGQGMRLIMTNFNHERLVIAIGVTRAARVALSAAFSYCLKREAFGKTLMDQPVVRHRLAKAGAELETMSAWVEQILYQLCHLSKEEGDLQLGGLTAMAKAKSAMVLNECAQVAVLLFGGNGFTQAGQGELVEAILRDVPGARIPGGSEDVLLDLSVRQLVKIYQAQEKKLSQSSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ37</accession>
    <name>A0A9X0BJ37_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_009449</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785766.1">
        <property type="nucleotide sequence ID" value="XM_056939044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJ37"/>
    <dbReference type="GeneID" id="81629294"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000139">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000535">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15413">
        <property type="entry name" value="PH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="81"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="562"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="267"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="466"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5466720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="852" mass="93440" checksum="47654684A0BDC904" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ99</accession>
    <name>A0A9X0BJ99_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative transcription factor kapC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_008887</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785859.1">
        <property type="nucleotide sequence ID" value="XM_056938482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJ99"/>
    <dbReference type="GeneID" id="81628732"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AP-1-like"/>
    </dbReference>
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        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="10">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="220"/>
        </location>
    </feature>
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            <begin position="241"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
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            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
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            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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            <end position="258"/>
        </location>
    </feature>
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            <begin position="274"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004049"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00044067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5469269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="285" mass="31118" checksum="5D008962E51C562A" modified="2023-11-08" version="1">MQPALAPAPHPSMQNPAQDHADQVLHDQLLAAQQHMHRPQGAPVQQHLQPNTGAPRDQGNIDPAISGAMMAAAPQTPNPPQQGSPDDGTPKTYGKRELSTSKRAAQNRAAQRAFRQRKETYIRKLEEEVKGMEGLREQIKALLHENYTLRDHIITMQSRLIDASVDVPELPPNIDLSQPRHDLSSMGAAVLPSTGPAVPVPPVNAPQQPQHTSSANEDMNSLNRIAVAGLGMRKHPDENAFLTNTFQPHTPPNNSNNGNKRRDEAQSDGTETLSKQEVHHGLPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJP1</accession>
    <name>A0A9X0BJP1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PH-response regulator protein palI/RIM9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_009307</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786279.1">
        <property type="nucleotide sequence ID" value="XM_056938902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJP1"/>
    <dbReference type="GeneID" id="81629152"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040783528" evidence="7">
        <location>
            <begin position="27"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="208"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5469689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="523" mass="56049" checksum="837F17991E61C936" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJZ7</accession>
    <name>A0A9X0BJZ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_009350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786322.1">
        <property type="nucleotide sequence ID" value="XM_056938945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJZ7"/>
    <dbReference type="GeneID" id="81629195"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="AMELOGENIN"/>
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    </dbReference>
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        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
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    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="372"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5469732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1166" mass="132896" checksum="4FB7D85B3F1EC4FE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNQ0</accession>
    <name>A0A9X0BNQ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_007739</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056937340.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
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    </dbReference>
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        <property type="entry name" value="ESTERASE OVCA2"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="13"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5475452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="270" mass="29222" checksum="2C4D04C828BFB5EF" modified="2023-11-08" version="1">MAPNPSAASGRPPLRILMLHGYTQSGPLFHAKSRALVKHIQKNFPSHEVVASYPTGPLKLRPSDVPGYEPSEGNGTNNEDEIEAYGWFRRSNTSDPPLYQGLEDGLAAIAKVLSEEGPFDGVIGFSQGAAMVGMVAGLLETGRQEAFAHFEQHDSGGASGIPYPASFAAPDFQHPRSSLQSHTTPVLHVLGSLDAVVEESKSRALIEACAGKPEADGLVVWHPGGHFLPSQRPYLDAVARFIREQLEKNDGKKKTEEEEEEDVNDMDVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BS52</accession>
    <name>A0A9X0BS52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Eurotiomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
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    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5480754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="196" mass="21810" checksum="4C52733C788125DF" modified="2023-11-08" version="1">MASNPSPGNGVYPNGPSMRQPSLSWMYRLECDISKEELDLGAAHDAGTIRKISNIERGTLKGLDIEATLLPLGGADWLTVIKGTHSMTLDARYTARTTDGHYIYFRAHGLYRPGPGTDYAMAVEHDWEQPPKAVVTQDDVEFFSHLRLEAGPGPYNWVNGLICVGVMVCEREKIWIDAYRLTNFPDRKPESVVAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSC4</accession>
    <name>A0A9X0BSC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein pim1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_006874</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788410.1">
        <property type="nucleotide sequence ID" value="XM_056936475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSC4"/>
    <dbReference type="GeneID" id="81626724"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00625">
        <property type="entry name" value="RCC1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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        <location>
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            <end position="216"/>
        </location>
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            <end position="577"/>
        </location>
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            <begin position="217"/>
            <end position="299"/>
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            <begin position="300"/>
            <end position="352"/>
        </location>
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    <feature type="repeat" description="RCC1" evidence="3">
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            <begin position="353"/>
            <end position="406"/>
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    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="407"/>
            <end position="463"/>
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    </feature>
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            <begin position="464"/>
            <end position="527"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <end position="134"/>
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            <begin position="244"/>
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        </location>
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            <end position="24"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
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            <end position="102"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
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            <end position="119"/>
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            <begin position="248"/>
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        <location>
            <begin position="262"/>
            <end position="276"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5480980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="581" mass="61342" checksum="E3F5AE412C2AE64C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9X0BSQ0_9EURO</name>
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        <submittedName>
            <fullName evidence="4">D-aminopeptidase</fullName>
        </submittedName>
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    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">IBT 30728</strain>
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    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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</entry>
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        </source>
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</entry>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUB0</accession>
    <name>A0A9X0BUB0_9EURO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5484963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="72" mass="8599" checksum="9FA75418F1480F83" modified="2023-11-08" version="1">MPCSTLNSIIPPRSHPIPPVPNPAPVGPAPLPPRPRRKLCLGRGLIYYYYYYYYYYYYYYYYPKPGLDIRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUJ3</accession>
    <name>A0A9X0BUJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small EDRK-rich factor-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790018.1">
        <property type="nucleotide sequence ID" value="XM_056934824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUJ3"/>
    <dbReference type="GeneID" id="81625073"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5485234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="70" mass="7706" checksum="CC048618F1AAC774" modified="2023-11-08" version="1">MTRGNQRDHDRAKAQKKAASAKSKNTLSGTEFQRAKEDAAAIMREKQRKGMWIPSGPASRSVISMCANVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUU1</accession>
    <name>A0A9X0BUU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mevalonyl-coenzyme A hydratase sidH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789975.1">
        <property type="nucleotide sequence ID" value="XM_056934781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUU1"/>
    <dbReference type="GeneID" id="81625030"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF158">
        <property type="entry name" value="ENOYL-COA HYDRATASE (AFU_ORTHOLOGUE AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5485191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="334" mass="36227" checksum="E38292739F623C4E" modified="2023-11-08" version="1">MPPFARPPPSTQYAQLSFPSTHVLLVTLNRPRDLNCINSQGHAELHDVWEWMDDEPSLRVGILTGKGRAFCAGADLKGISRLIMNPPSRASRSESSSSRNPPFSVSPLLVPMNIVQAKPIESPEWNNSAQASTSKSPMPVSGFGGLSRRKGRKPIICAINGLCFGGGTEMIINADLVIASSLAKMGLPEVKRGVVALAGALPRLIRTIGRQRAMEMALTGRAYTAEQAERWGLLNEVVSVGDCVVDGKPDDEAVSERVVGRAVQIAIEIAENSPDAVLVTREGVKLGWEGIGAEEATGLLNETWVRRLYEGENIKEGLKAFVEKRKPNWRDSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUU2</accession>
    <name>A0A9X0BUU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD dependent epimerase/dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790066.1">
        <property type="nucleotide sequence ID" value="XM_056934872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUU2"/>
    <dbReference type="GeneID" id="81625121"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF3">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5485282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31582" checksum="6A93913C880B6383" modified="2023-11-08" version="1">MEKSTEQQRWRDPFAGEPPRDPSRTLQVIGAGLPRTGTISLTLALTWALHGDVCHGGSACLRGKEHIIKGWTKCLDPPKDVSQEEVDKTLKDLLVGYVATTDAPAIFFVEELVRLYPDAKVVCTTREPTRWWESYQELINTLDNPLFILLQLVQPTLRYSLAWKLAIVKRRRQIYPAELEPLGPHFMELHSDYLKRVVPKDRLLFFDMKEGWEPLCKFLDVPIPEKPFPQVHDRASMKSSWAPYWWRGAAIWLTILAAGYGLSQAVSYARLRMHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXB1</accession>
    <name>A0A9X0BXB1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_003481</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790624.1">
        <property type="nucleotide sequence ID" value="XM_056933083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXB1"/>
    <dbReference type="GeneID" id="81623332"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="34"/>
            <end position="466"/>
        </location>
    </feature>
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        <location>
            <begin position="487"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5488591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="512" mass="57594" checksum="C63CAE9DC6806570" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYM5</accession>
    <name>A0A9X0BYM5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_002422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791984.1">
        <property type="nucleotide sequence ID" value="XM_056932025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYM5"/>
    <dbReference type="GeneID" id="81622274"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5490855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="68" mass="7855" checksum="2FB7173C97388795" modified="2023-11-08" version="1">MVGSVRRLQDFLTGKWLDLLAEGLPEKSTVVSEPHKLQREHFVSANLREEKLQDMLFWSNIYGGLPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYS8</accession>
    <name>A0A9X0BYS8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">N7539_002543</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792105.1">
        <property type="nucleotide sequence ID" value="XM_056932146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYS8"/>
    <dbReference type="GeneID" id="81622395"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF82">
        <property type="entry name" value="CYTOCHROME B2, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="32"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="18">
        <location>
            <begin position="128"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ5490976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="537" mass="59406" checksum="857F0FF260C5A211" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZJ6</accession>
    <name>A0A9X0BZJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter cpaT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_002814</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792376.1">
        <property type="nucleotide sequence ID" value="XM_056932417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZJ6"/>
    <dbReference type="GeneID" id="81622666"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="90"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5491247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="528" mass="57830" checksum="E15C39A591D8E23A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C020</accession>
    <name>A0A9X0C020_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792914.1">
        <property type="nucleotide sequence ID" value="XM_056930883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C020"/>
    <dbReference type="GeneID" id="81621132"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="218" mass="23772" checksum="15498150FF4CA337" modified="2023-11-08" version="1">MSFLAGLCSCFSSGDVQPQVALSRPEMQMRSSSNVTPSGVQTGSYTYNDRGEVVRIENPLARRLGHGPSRSDLDSGGYASVVPLPQYTPRPMSVHEKTLEAHLRDAPVSSDSSSVYQDEKRRQAYEDEATSDDSSVFSYPSSFGNTSTATRETPPPPYSPRGSMMIGRSRTASISSTMDVTVRPPPLARLHGACITAVPSEADDQSIRRHRRGSWQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C081</accession>
    <name>A0A9X0C081_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit DUO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein DUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">N7539_001939</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DUO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793573.1">
        <property type="nucleotide sequence ID" value="XM_056931542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C081"/>
    <dbReference type="GeneID" id="81621791"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013960">
        <property type="entry name" value="DASH_Duo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08651">
        <property type="entry name" value="DASH_Duo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="146"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="272"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="179"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ5493193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="394" mass="43398" checksum="1DC5245BB6D54EF1" modified="2023-11-08" version="1">MAARNTADEMRQIQLSGEDSEDLWNSPSKRGPQRPFKVPTPNNAPSPGPRQVPVADDTLFDRHEAREAALQHELHTVRNINEVIEGLLNSIDKAQGNMEALTSASTLLNTWTRILSQTEHNQRLILNPDWQGATQDVADMEREAIQRQQAAERREQALQEQREAAMRRAEEEERRRLATGRSSRGTTRGTVRSTGLGRTPSVSTSRSATARGASTTATRRPASGIARGSGIARGRASLAFVESVLAPRLVMNFAPYQDESPEIERALSPPTVDNRIRSPAFRSPRASTDLPSPSQFAASGHGNPSFGRDVEGGHVSFGAFETSLPIRMDIEAALAYLLLPPREVSFCCCWSIRATTCGAYRSCLLPHARVKVDTLDHFEVPFIGYWANSFVDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2A1</accession>
    <name>A0A9X0C2A1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_000544</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794441.1">
        <property type="nucleotide sequence ID" value="XM_056930148.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81620397"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14012">
        <property type="entry name" value="PK_eIF2AK_GCN2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14046">
        <property type="entry name" value="STKc_EIF2AK4_GCN2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000050">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000379">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2-alpha kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000821">
        <property type="entry name" value="Serine/threonine-protein kinase gcn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000074">
        <property type="entry name" value="Serine/threonine-protein kinase gcn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016255">
        <property type="entry name" value="Gcn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024435">
        <property type="entry name" value="HisRS-related_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF136">
        <property type="entry name" value="EIF-2-ALPHA KINASE GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12745">
        <property type="entry name" value="HGTP_anticodon2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000660">
        <property type="entry name" value="Ser/Thr_PK_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RWD" evidence="15">
        <location>
            <begin position="43"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="269"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="576"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="691"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1435"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="708"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1435"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1446"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="790"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="582"/>
            <end position="590"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="605"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5495428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1586" mass="179436" checksum="555FF2D097458BDC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2E4</accession>
    <name>A0A9X0C2E4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_000679</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <text evidence="11">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794576.1">
        <property type="nucleotide sequence ID" value="XM_056930283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2E4"/>
    <dbReference type="GeneID" id="81620532"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000355">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="6 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="12">
        <location>
            <begin position="104"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="13">
        <location>
            <begin position="331"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5495563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1007" mass="112043" checksum="233BC46DD53E0CA5" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2I4</accession>
    <name>A0A9X0C2I4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Proline-specific permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_000215</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794112.1">
        <property type="nucleotide sequence ID" value="XM_056929819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2I4"/>
    <dbReference type="GeneID" id="81620068"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF21">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="47"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5495099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="545" mass="58616" checksum="0490698CD0339FE4" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2R5</accession>
    <name>A0A9X0C2R5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_000455</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794352.1">
        <property type="nucleotide sequence ID" value="XM_056930059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2R5"/>
    <dbReference type="GeneID" id="81620308"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031332">
        <property type="term" value="C:RNAi effector complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00175">
        <property type="entry name" value="SNc"/>
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        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000001">
        <property type="entry name" value="Staphylococcal nuclease domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription factor (Snd1/p100), putative"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SNase_OB-fold_sf"/>
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    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
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        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
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        <property type="entry name" value="STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1"/>
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        <property type="match status" value="4"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5495339.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2T6</accession>
    <name>A0A9X0C2T6_9EURO</name>
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        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">N7539_001099</name>
    </gene>
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        <name type="scientific">Penicillium diatomitis</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5495983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="281" mass="30278" checksum="7EEB0AA810CC0075" modified="2023-11-08" version="1">MKLFTAPHMLALSLAASQGFAAMTQGVSQDVYNRLVEMATISQAAYANLCKIPSTISIVGKIYNSQTDINGWVLRDDSRREIITVFRGTGSNTNLQLDTNYNPAAFQTNPKCEGCFVHGGYYTGWLSVKDQVESLVDSQVNQHQGYALTVTGHSLGASMASITAAQLAATYSDISLYTFGEPRTGNQAFADYMNEHFHAGSASTTRYFRTTHANDGIPNVPPTSMGYVSSGVEFWSVDPYNAHNIFVCTGNGDQCCEAQGGQGVNGAHTTYFGMTSGACSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2Z2</accession>
    <name>A0A9X0C2Z2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein mms22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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        </lineage>
    </organism>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056930691.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81620940"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019021">
        <property type="entry name" value="Mms22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09462">
        <property type="entry name" value="Mus7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="268"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="870"/>
        </location>
    </feature>
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        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
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        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
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        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2287" mass="257015" checksum="BCB8BCDDD0DBC53B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2Z3</accession>
    <name>A0A9X0C2Z3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_000786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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</entry>
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</entry>
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        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_009086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
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            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5469468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="39767" checksum="4778364D66644868" modified="2023-11-08" version="1">MTDPLKSYDVAGRPQPTALSQKVYNIAGISVTVYGLDELRSQTSSVACLWLLHPRLATQARMTGIAEATIHDWNSKIQTPAAAKGLIAVSFDQRNHGARMVDPLANEAWRQGNPRHAQDMFAIFQGTARDTSLLMDYLAAFIFPNGEHQITENLVLGVSLGGHAAWSCLLHEPRVSAGVVIIGCPDYLNLMVDRARLSKLPSWTKSDPPGAEILGSEAFPTPFVDIVKRYDPASLMLTCMDGTSTGLPREGGKALPEPTEEQKKELKPLLTRLLTGKRILNLSGGIDKLVPYHRGEAFLTWFKKAVAADGWFGDGGVTFEDIIDESAGHEVTPKMVDEAVRFVSETLASSSGSKNRRGSVRESKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL91</accession>
    <name>A0A9W9WL91_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Extracellular serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_009208</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
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                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056938803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL91"/>
    <dbReference type="GeneID" id="81629053"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056825">
        <property type="entry name" value="Agd3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056826">
        <property type="entry name" value="Agd3_CE"/>
    </dbReference>
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        <property type="entry name" value="CBM87_Agd3"/>
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    <dbReference type="InterPro" id="IPR050788">
        <property type="entry name" value="Yeast_SRP1/TIP1_CWP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002:SF34">
        <property type="entry name" value="CELL WALL PROTEIN CWP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002">
        <property type="entry name" value="SERIPAUPERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25117">
        <property type="entry name" value="Agd3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25115">
        <property type="entry name" value="Agd3_CE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25116">
        <property type="entry name" value="CBM87_Agd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Agd3 CBM87" evidence="3">
        <location>
            <begin position="151"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 deacetylase" evidence="2">
        <location>
            <begin position="355"/>
            <end position="720"/>
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    <feature type="domain" description="Agd3 C-terminal" evidence="4">
        <location>
            <begin position="721"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5469590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="789" mass="84137" checksum="6AFACCDF6BB048DA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLE3</accession>
    <name>A0A9W9WLE3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786205.1">
        <property type="nucleotide sequence ID" value="XM_056938828.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81629078"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
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        <location>
            <begin position="288"/>
            <end position="379"/>
        </location>
    </feature>
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        <location>
            <begin position="431"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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    </feature>
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            <end position="339"/>
        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="451"/>
        </location>
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            <end position="480"/>
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    </feature>
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        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5469615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="779" mass="83216" checksum="57D42228676BD073" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLK6</accession>
    <name>A0A9W9WLK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">N7539_009344</name>
    </gene>
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        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
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    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786316.1">
        <property type="nucleotide sequence ID" value="XM_056938939.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A9W9WLK6"/>
    <dbReference type="GeneID" id="81629189"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:Golgi apparatus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01214">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040782316" evidence="8">
        <location>
            <begin position="21"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="321"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5469726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="505" mass="53232" checksum="CBEC13187AB17B80" modified="2023-11-08" version="1">MKFLIPPSLALVLLPALTIAATDVNLARQLNAREAGASSDSNAVYVDAEPAVYNTAAKGSPDAPVDGKDGKPHAGPWVDTATDRDRKAKGSDEAKGGVMDDPSRTGPKEGTRGTEGGVSEKEKVNQGTSEKVPGSPKEAPPRPHSEKQKQSDDSEASVGNGGRTSDDASALGMLEKPADLPSKPHDIPHPKSPSQVKQDPLAVQQGSTGTGSYPSSKSPGLTTGEKAVGESDGLHSLLFSFTMIIVSEIGDKTFLVAALMAMRHPRLVVFSAAFCALFVMTVLSAILGHAVPTLIPKSVTKLMAAVLFLIFGAKMLKEGREMSPDEGVGEEMREVEMELEEKEQEQRRMGRRRSSVTPHSLEAGRAGARAKSRGSSNRLPSPPESISSSSSRGSSPTPGRRLNDMMNGVGNLFSLLLSPAWVQTFVMTFLGEWGDRSQIATIAMAAGQDYWWVTVGAITGHGICTAAAVIGGRAIAGRVSLRVVTLGGATAFLVFGIIYLIEAMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLR1</accession>
    <name>A0A9W9WLR1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786033.1">
        <property type="nucleotide sequence ID" value="XM_056938656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLR1"/>
    <dbReference type="GeneID" id="81628906"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5469443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="290" mass="32683" checksum="8EEB87E1CFD79774" modified="2023-11-08" version="1">MMATKADPDVRADVDLMVLDYLATLAIGRVLTAAGNPTKTPRLEEEVDWQVRTVKVFHANMMTACEDIATSSDLEIKLQILEFVNEFWNHPGPPKSSSRNTASNSNQDPSKTSAQAMDQNTSDDFKTSSTNPQSLQLPLGTIGLDFLELCDRASAKVSPTRWFDLGARFVVQSELEDYPTCHDGMSSRAAELFQWLPRNPDLKPKWVAMQGQYVLRANIYELEDGDERNAMWEQLKDENPFDKFRSMVIAFVDDLMDTLDPPVLLQLECGKLGSLTEAETRELKERIGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLT7</accession>
    <name>A0A9W9WLT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Btz domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_009106</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CASC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786078.1">
        <property type="nucleotide sequence ID" value="XM_056938701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLT7"/>
    <dbReference type="GeneID" id="81628951"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018545">
        <property type="entry name" value="Btz_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044796">
        <property type="entry name" value="MLN51_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46837">
        <property type="entry name" value="PROTEIN MLN51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46837:SF5">
        <property type="entry name" value="PROTEIN MLN51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09405">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01044">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Btz" evidence="14">
        <location>
            <begin position="123"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="294"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="449"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5469488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="672" mass="72994" checksum="494F3877A3F93178" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WM01</accession>
    <name>A0A9W9WM01_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_009211</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786183.1">
        <property type="nucleotide sequence ID" value="XM_056938806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WM01"/>
    <dbReference type="GeneID" id="81629056"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5469593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="514" mass="55853" checksum="66626DDA946BE8F9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQN4</accession>
    <name>A0A9W9WQN4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_008787</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786390.1">
        <property type="nucleotide sequence ID" value="XM_056938382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQN4"/>
    <dbReference type="GeneID" id="81628632"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005919">
        <property type="entry name" value="Pmev_kin_anim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF25">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04275">
        <property type="entry name" value="P-mevalo_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="311"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5471844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1148" mass="125667" checksum="D19BDA0FCEF2DD89" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQQ2</accession>
    <name>A0A9W9WQQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_008509</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786486.1">
        <property type="nucleotide sequence ID" value="XM_056938104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQQ2"/>
    <dbReference type="GeneID" id="81628354"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="46"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5471940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="400" mass="45509" checksum="2DFEA409778E6AE9" modified="2023-11-08" version="1">MSTNADKSPMDQPTYICPIEAEPLHRYRQGGYHPVTLGECLKAGRYKVLHKLGWGGYSTVWAARDHRTETYVAVKISVAEQDHDRETRELQTMRELASYHPSPTHVVQLLDDFDLTGPNGFHKCLVYELLGPNIPDVIDAHFTGGRLPGGLAKIIAKQSLAALNDLHQRNIGHGDLHTRNLAFTMRCMDKVTEDVFFEILGKPEIGRVQRHDGKDLELGVPKYIVKPTSYRTRSWNSTQSIKIIDFGESFLCNAAPHTLHTPLPVRAPEVLFQDPIDYHVDLWSMGCMLFELFTGQPPFDTFLITTPILISQMQEMASDDLPKRWQKIWDTMDKGDVTAESSGPNLHEWLEEVYFDGRRTPDLTREDITRLGEIIGRLLCFEPSARASARQILDDPWFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQX0</accession>
    <name>A0A9W9WQX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786591.1">
        <property type="nucleotide sequence ID" value="XM_056938209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQX0"/>
    <dbReference type="GeneID" id="81628459"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050977">
        <property type="entry name" value="Fungal_Meroterpenoid_Isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39598:SF1">
        <property type="entry name" value="AUSTINOID BIOSYNTHESIS CLUSTERS PROTEIN F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39598">
        <property type="entry name" value="AUSTINOL SYNTHESIS PROTEIN F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5472045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="158" mass="17732" checksum="8463563D7CE16B76" modified="2023-11-08" version="1">MPTLYEQCGDTALAFIGSFQGSVPEAIIAHRAKNCLHRIRSGSLSSGPMTNAEYCAWVKSLMPVMRNFQLHLQEGHLPIIDATQRKVTLYLRSTSDTDFGNYSNEYIWILSLDDTGRKVNDIMEFTDSEYTSNWIPKLMKAAVLKGTNMVSLGNYSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WRB9</accession>
    <name>A0A9W9WRB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786449.1">
        <property type="nucleotide sequence ID" value="XM_056938067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WRB9"/>
    <dbReference type="GeneID" id="81628317"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="142" mass="13998" checksum="29D3D5174066DDBF" modified="2023-11-08" version="1">MNGSAFVCAGLEILLDGSSSTQYSQSLLARQGNACECESSVASVSTTTVTLIQASTSTASSTAPTGSTSTAVSTKSTSYTSTASSTAPISPTSSTSSASTDSSTTSTSKASSTHTSPDRTSSPLSSPSSTPGILTELSCLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WT13</accession>
    <name>A0A9W9WT13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5474990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786748.1">
        <property type="nucleotide sequence ID" value="XM_056937656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WT13"/>
    <dbReference type="GeneID" id="81627906"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48172">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48172:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040884648" description="Vacuolar protein sorting-associated protein 62" evidence="2">
        <location>
            <begin position="22"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5474990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="72476" checksum="18CAE3475D1991AE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WT91</accession>
    <name>A0A9W9WT91_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
            <ecNumber evidence="9">1.13.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilate oxygenase</fullName>
            <shortName evidence="9">3-HAO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilic acid dioxygenase</fullName>
            <shortName evidence="9">HAD</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Biosynthesis of nicotinic acid protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BNA1</name>
        <name evidence="10" type="ORF">N7539_008161</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:17953"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:77612"/>
            <dbReference type="EC" id="1.13.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 3-HAO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.6" evidence="9"/>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WT91"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000093">
        <property type="entry name" value="3-hydroxyanthranilate 3,4-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00825">
        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF1">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5475095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="192" mass="21745" checksum="9DE59901241072BA" modified="2023-11-08" version="1">MLPPALNIPKWLEENSHLLQPPVNNYCVYHPSNPATAGYTVMIVGGPNARTDYHINTTPEFFYQYRGSMLLKTVDTSTTPPTFHDIPVHEGSIFLLPANTPHCPVRFKDTVGVVMEQPRPEDAVDVMRWYCRDCQEIVWEKRFVCTDLGTQVKQVVEEFAADEDKRTCKKCGRIAAVKYAEGDLVQPPAHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WT95</accession>
    <name>A0A9W9WT95_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_008163</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786855.1">
        <property type="nucleotide sequence ID" value="XM_056937763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WT95"/>
    <dbReference type="GeneID" id="81628013"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13986">
        <property type="entry name" value="STKc_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000550">
        <property type="entry name" value="Serine/threonine kinase 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000374">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000728">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052239">
        <property type="entry name" value="Ser/Thr-specific_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="32"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="172"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5475097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="423" mass="46639" checksum="965C8BB3C906C750" modified="2023-11-08" version="1">MAQYFFDLLYNFTDCMCCFPSTPQLKINNRSFKLLRLLGEGGFSYVYLVQDKTSSELFALKKIRCPFGQESVSQALKEVEAYGLFTSHKNIIHAIDHCVSTESGSKFRSDGGEPGSKTVYILLPYYQRGNLQDAINANLVNHTRFPEKRLMVLMLGVAQALKAMHQYRVQSGSASTRQAKAVRREGEEADNARTMQMKPKRRAGHTADEEDEENEPLMDDEVTQSQEGVQEGGLRPYAHRDIKPGNIMIDDDGQNPILMDLGSLAPSPIAITSRSLALAVQDTAAEHSTMPYRAPELFDVKTGSIIDTKVDIWSLGCTLYACLVGKSPFEARSDETGGSLSMCVLGGDWRFPDEKSGATKGKAKVGGDADAGSSSSEQVISEPVKEIVRRCLQVEPADRPDIDELIQMMKDMISELPDDDGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU29</accession>
    <name>A0A9W9WU29_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787300.1">
        <property type="nucleotide sequence ID" value="XM_056937435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WU29"/>
    <dbReference type="GeneID" id="81627684"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="385" mass="42882" checksum="1D52D92DD5BD61CC" modified="2023-11-08" version="1">MGLNKPNQLSITRRLRHQSQSQRFPLVNKWTIDFSSERTLADQASPDNLPASKRLPQSPLITHPQPGPVKIRKNRPTRNDTSELEKNPWAVALASPVRMCSVTGARIPRDLLGEWGLVRKPDTENHYLLPVGLMKDALKPRSKAEANGPEEVRADLPSTDEATQESTIVNAVRQEKPGQQLLLRMINSQPLLQALSKPLSRNSGKRPAIAKILPFRWKHPLGPITSRVEKQLLWRPDMADYVLRQRQQAVINSLDKVQRRHPRLDLPEGAWKVLDVHEPSVTAISEALGRLGPLERMASGVILLLSPLGGSAPTAETLYSPTTESEVPLFDLPALLTPSDLAKLRATEPGYFHGDAVFFRPDNRVDVEAVLALWNLQRYAAGVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUE1</accession>
    <name>A0A9W9WUE1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787422.1">
        <property type="nucleotide sequence ID" value="XM_056937557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUE1"/>
    <dbReference type="GeneID" id="81627806"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF39">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="70"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5475669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="289" mass="32154" checksum="150691A101421354" modified="2023-11-08" version="1">MELFMRPIADPQSREPDGSFPLDGKDLNSVTDEALATLLTTAPILHQLGGTTVVRLSENLIMKGGGSVMASEAEMLRLIASRTTIRAPRVYRSFQVKDDTQYFGTSGYIVMDFIPGQPLDECWNALSRDTQGKIAAQVAEMIQEMQSIELLKPGPIGGGPCRGRFFTDYSAGPFTDTTEMEAWFNHKLEICKSVHQAPKDVPPFYFTKFVLTHHDISPRNLILDQHEQAWLIDWAYSGAYPPVFESAALSIQPFFTDFNEAVLSLITRHPEEEMQLDSIAYGLTTAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUP6</accession>
    <name>A0A9W9WUP6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_007215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787615.1">
        <property type="nucleotide sequence ID" value="XM_056936816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUP6"/>
    <dbReference type="GeneID" id="81627065"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17781">
        <property type="entry name" value="CBS_pair_MUG70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17782">
        <property type="entry name" value="CBS_pair_MUG70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051462">
        <property type="entry name" value="CBS_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108:SF26">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN DDB_G0289609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="109"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="176"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="279"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="345"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="6">
        <location>
            <begin position="478"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="423"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="577"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5477071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="667" mass="72058" checksum="B1ED514A8E8720C6" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUY9</accession>
    <name>A0A9W9WUY9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787569.1">
        <property type="nucleotide sequence ID" value="XM_056936770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUY9"/>
    <dbReference type="GeneID" id="81627019"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="63895" checksum="9287C4633C4B8B5F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV10</accession>
    <name>A0A9W9WV10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein root UVB sensitive/RUS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_007338</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787738.1">
        <property type="nucleotide sequence ID" value="XM_056936939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV10"/>
    <dbReference type="GeneID" id="81627188"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="6">
        <location>
            <begin position="34"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5477194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="465" mass="50373" checksum="211D5B6D569BCAD4" modified="2023-11-08" version="1">MTEKDARVVSLVLQASRCLPWRCISSIGISSERVGVGNADASPTSALLLHILQDTSGRIATILFAHRVSTALEPECKTYRLAADVFNDLAMVLDCLSPMVPAGFMRVTAGVLRALCGVAGGSSKASLSAHFARWGNLAELNAKDSSQETVISLIGMLVGSVVVSHVTGFTSTWIALLCLLGLHLGMNYAAVRSVQMTSLNRQRANIVFSALFESDSKLNQSIGRTRSLRHVSTGLDPAIKFSPSRHISQSSNSPIFLTPAQAASQEYIFPRQDTLTWTSPFGRHASGAPTSVSPFECFLKQARRHASSLTTPTTNQSPSSFHTTVPMIQLAELYADEKYLIYLFPRTKRSPPSTQTWHASILLKKDCTIPDQLKAWAHALLAARVLNMDCEKGRFPGGYGAEKSTVSVSVSNTTDLVMSCMADTLSVLNEGGRFGEYLDVMRANGWDVDIGALETRGGEELNVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVR4</accession>
    <name>A0A9W9WVR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit OST2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_007559</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DAD/OST2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787959.1">
        <property type="nucleotide sequence ID" value="XM_056937160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVR4"/>
    <dbReference type="GeneID" id="81627409"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003038">
        <property type="entry name" value="DAD/Ost2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02109">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005588">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5477415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="165" mass="17495" checksum="9289DA85FE0EB8D5" modified="2023-11-08" version="1">MPAKRHAASTNTSAAVPVTPATLSSGPTTLKTNASAVAIAQNVWEQYVATTPQRTLLLDAFMAFLVLVGGLQFLYCVLAGNYPFNAFLSGFSAAVGQFVLTASLRMQTSDSGSTLSSKPSSKGKNARFANEDNEGQGSGISHERAFADYIFGSLILHFFCVNFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1N8</accession>
    <name>A0A9W9X1N8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788163.1">
        <property type="nucleotide sequence ID" value="XM_056936228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1N8"/>
    <dbReference type="GeneID" id="81626477"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5480733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="44026" checksum="CC9088FA62353D51" modified="2023-11-08" version="1">MAPGTSAPAALLLLPPPPSFSLHPLKKVFEEPLAEAICKIVKSLNDPQQTATLDVVLQVPGLLSASSRPRASVFAPLQHYLSSIYTLIGAAAAARQVELDAPGGLDARVLFTSGPDSCSSPSGLGFGPIVDLKSLVTSARQWNQVFYLGVESGRQLYQDFLRVNDHNRSCTNLQDHELSNMNSQWSVPSTLLQASPPGATDLRPHYSVCVGGTFDHLHLGHKLLLTALALTVESPTDADQHQERLLTIGVTGDALLKNKKYAEFLESWRARFESTAAFLRTIMDFTPHNKPRVEETHLPGPNGHSIIMHVLPHLTFKFVEIWDPFGPTITVESLTALVVSKETASGGVAVNEERSKKGWKNLTIFEVDVLQTGEVADVTDVNNFESKISSTDIRRRRMNLAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1U8</accession>
    <name>A0A9W9X1U8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase activator Bem1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_006782</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788318.1">
        <property type="nucleotide sequence ID" value="XM_056936383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1U8"/>
    <dbReference type="GeneID" id="81626632"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06890">
        <property type="entry name" value="PX_Bem1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11878">
        <property type="entry name" value="SH3_Bem1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11879">
        <property type="entry name" value="SH3_Bem1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000093">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000184">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000250">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000041">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035550">
        <property type="entry name" value="Bem1/Scd2_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035548">
        <property type="entry name" value="Bem1/Scd2_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035549">
        <property type="entry name" value="Bem1/Scd2_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="33"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="148"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="314"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="7">
        <location>
            <begin position="518"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="445"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5480888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="65454" checksum="4DFEEA0DC02D3CDF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X206</accession>
    <name>A0A9W9X206_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_006807</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788343.1">
        <property type="nucleotide sequence ID" value="XM_056936408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X206"/>
    <dbReference type="GeneID" id="81626657"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000020">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="10">
        <location>
            <begin position="698"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="645"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="645"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="5"/>
            <end position="6"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="50"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5480913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="941" mass="105569" checksum="3104099F0E1A3F92" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X249</accession>
    <name>A0A9W9X249_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear control of ATPase protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_006883</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788419.1">
        <property type="nucleotide sequence ID" value="XM_056936484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X249"/>
    <dbReference type="GeneID" id="81626733"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5480989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="71981" checksum="919737FF2F30F5CF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2H6</accession>
    <name>A0A9W9X2H6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_007075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788611.1">
        <property type="nucleotide sequence ID" value="XM_056936676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2H6"/>
    <dbReference type="GeneID" id="81626925"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF2">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040785813" description="Phosphatidate phosphatase APP1 catalytic domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="3">
        <location>
            <begin position="282"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5481181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="521" mass="56557" checksum="78485DF7651D7E7A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2N6</accession>
    <name>A0A9W9X2N6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788719.1">
        <property type="nucleotide sequence ID" value="XM_056935795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2N6"/>
    <dbReference type="GeneID" id="81626044"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF174">
        <property type="entry name" value="ARRESTIN-RELATED TRAFFICKING ADAPTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="1">
        <location>
            <begin position="258"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5482747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="532" mass="59462" checksum="33D72660F5744E51" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2Z1</accession>
    <name>A0A9W9X2Z1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788271.1">
        <property type="nucleotide sequence ID" value="XM_056936336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2Z1"/>
    <dbReference type="GeneID" id="81626585"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5480841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="189" mass="20876" checksum="DF5BE6C64E322945" modified="2023-11-08" version="1">MKYRRSEWTVRSLASDNRIVSRPSPLVQPVTHFGFICPSPPPAHLTIHPRHHFELGRRSSFLPFPSPLPDQLIQLSSAQLSSADLGLPSFEFHPLQLLDNGEVPLPSFRSPRSATPLALSSLAEIGRAAFRSSPPPPAGVYSVSHSPILIASFSLAFFFPPEQSMAFHALAPIRGPKKNPLIDRFLHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X305</accession>
    <name>A0A9W9X305_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">26S proteasome regulatory subunit rpn9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_006373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788899.1">
        <property type="nucleotide sequence ID" value="XM_056935975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X305"/>
    <dbReference type="GeneID" id="81626224"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040798">
        <property type="entry name" value="Rpn9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18261">
        <property type="entry name" value="Rpn9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="175"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5482927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="381" mass="43282" checksum="7328380FF484F2B7" modified="2023-11-08" version="1">MDASKIPDFLAEQQAKGTPETQTYFLTFEDYWERKLWHQLTDSMVEFFRMPESAPQRLAIFKAFVLSFADRINQLKFVSLGLMASTECSDNEERLAFLTALSNKVNKPESQDAYVYALADVASVKLRIPDLDGAQSDLATCQTVLDSFDSVETVVHASFYKVNADYYHAKQEFASFYKNALLYLACIDLKDLSETERASRAYNLSVAALVSDSIYNFGELLLHPILDSLTETPHNWLRDLLFAFNRGDLTAYDVLAGNISKNKLLESHRMFLYQKISLSALTEMVFRRPPHDRSLSFHDIAAETKVQPDEIEHLVMKALSLGLLKGSIDQVAQVAHIHWVQPKVLDMKQIEGMRNRLKDWDAGVNQLGHWIEGVGKDVWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X383</accession>
    <name>A0A9W9X383_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788988.1">
        <property type="nucleotide sequence ID" value="XM_056936064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X383"/>
    <dbReference type="GeneID" id="81626313"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5483016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="135" mass="14455" checksum="2C0C43825824607B" modified="2023-11-08" version="1">MTLAIQVSVRSAGSMRTCTPRLWSHSRASQKRFASTASENKGGVSRPLLIVGALAVPAALYMAREKGTFPALGNRNKKWDRPALIWSSLGKEDANHPGSASQHPYMAESGKSVKGEGVIDTARLNGPVRVDRPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3A0</accession>
    <name>A0A9W9X3A0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_006505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789031.1">
        <property type="nucleotide sequence ID" value="XM_056936107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X3A0"/>
    <dbReference type="GeneID" id="81626356"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5483059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="386" mass="43043" checksum="68456EEF295D9DB6" modified="2023-11-08" version="1">MPPRRAHTKSRNGCDQCKRRRVKCDEKGPPCSNCISRELNCTYLKAPPRDGTAVRKRSTASASTRELEVARPLAPISPASTPSSISGVRDLELMHKFATETFSTVCTAESKYHVWQIVIPRLALQYDFLMNGILALAASHIAATTESPTSLAYIDTALQYHNLSFAPFRAAIDNLTQENCEAVLAQSIVTTVIGIALPRLTASRDETSNMTENMLVVFQLLQGVKKIILIGRSWIKINLYSRHRELYEAAAPTELDGDAAAALDRLARLNEEAVAGVDVQQYRTNKEVIGHLRQCFTLYMSSRDPGEVLSWLAAVDKEFVDTVRRRQPLALLILMHWGVLLGELHGRWWWAQGSGKSLVAELSQSLSDAGARWSEFVTWPRRRLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3F8</accession>
    <name>A0A9W9X3F8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789008.1">
        <property type="nucleotide sequence ID" value="XM_056936084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X3F8"/>
    <dbReference type="GeneID" id="81626333"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5483036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="91" mass="10093" checksum="DDDA777F27CC2A32" modified="2023-11-08" version="1">MCPKARRDAINFGRRATKFISIVVEWDKLDYISTAISTVFDVDSNNLWVDSCAPEPKLKCGRDLTDEFSNVFNDGVGFEISGTLDLSTATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3K8</accession>
    <name>A0A9W9X3K8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_006436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788962.1">
        <property type="nucleotide sequence ID" value="XM_056936038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X3K8"/>
    <dbReference type="GeneID" id="81626287"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000002">
        <property type="entry name" value="Nitrilase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5482990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="303" mass="33000" checksum="A7F136A95B37422E" modified="2023-11-08" version="1">MATFLKKPLKLALVQLASGAHRQDFPPGADKAANLSHARSKVLEAAQGGARLIVLPECFNSPYGTQFFPKYAETLHPSPPSKEQSPSFHALSAIAAEANAYLIGGSIPELEPESKKYYNTSLVFSPSGSLIGTHRKTHLFDIDIPGKIKFKESDVLSPGNELTVIDLPEYGKIGLAICYDIRFPESAMIAARKGAFLLVYPGAFNTTTGPLHWSLLGRARAVDNQTYVALCSPSRDLEATYHAYGHSLIADPSAGILTEADEKETIIYADLDNETIVNTRKSIPIYTQRRFDVYPDVSGQSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3N6</accession>
    <name>A0A9W9X3N6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">DNA replication ATP-dependent helicase/nuclease</fullName>
            <ecNumber evidence="22">3.1.-.-</ecNumber>
            <ecNumber evidence="22">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">N7539_006105</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="29" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 22">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="22"/>
    <dbReference type="EC" id="3.6.4.12" evidence="22"/>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788631.1">
        <property type="nucleotide sequence ID" value="XM_056935707.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81625956"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071932">
        <property type="term" value="P:replication fork reversal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18041">
        <property type="entry name" value="DEXXQc_DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22318">
        <property type="entry name" value="DNA2_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000789">
        <property type="entry name" value="DNA replication ATP-dependent helicase/nuclease DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001170">
        <property type="entry name" value="DNA replication helicase Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.320.10:FF:000001">
        <property type="entry name" value="DNA replication helicase Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026851">
        <property type="entry name" value="Dna2/JHS1_DEXXQ-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048459">
        <property type="entry name" value="DNA2_Rift"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF433">
        <property type="entry name" value="DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21123">
        <property type="entry name" value="Dna2_Rift"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 22" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="22" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 22" id="KW-0227">DNA damage</keyword>
    <keyword evidence="18 22" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 22" id="KW-0235">DNA replication</keyword>
    <keyword evidence="16 22" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="11 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 22" id="KW-0408">Iron</keyword>
    <keyword evidence="15 22" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20 22" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 22" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19 22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="25">
        <location>
            <begin position="590"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="DUF83" evidence="24">
        <location>
            <begin position="801"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2 rift barrel" evidence="28">
        <location>
            <begin position="964"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="26">
        <location>
            <begin position="1153"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="26">
        <location>
            <begin position="1257"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="27">
        <location>
            <begin position="1329"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="134"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="301"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1602"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1612"/>
            <end position="1623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU367041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF21123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KAJ5482659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1674" mass="186331" checksum="E9971B99FCBAC139" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5E9</accession>
    <name>A0A9W9X5E9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_005756</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789230.1">
        <property type="nucleotide sequence ID" value="XM_056935358.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81625607"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative pyridoxal kinase C6F6.11c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="8">
        <location>
            <begin position="117"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5483960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="370" mass="40122" checksum="A1D480E87E7276D3" modified="2023-11-08" version="1">MSDVLVPETRVLAVASHVAYGHVGNTMAGFVMQSLGCEVAALNTVNFSNHTGYRQFKGTRATAQEITDLYQGLCQSNLTDFDVMLSGYAPSAAAVEAVGAIGIDLQKKAESKPGSFFWVLDPVMGDQGRLYVNDDVVPAYKKIIHHADLILPNQFEAEVLSGIKITSLATLAEAITAIHKIYSVPHVIITSVQLPGSATVESSPSSSQNFLTIIGSTTRSNGTPRLFQVDVPALDCFFSGTGDMFAALTVARLREAVVNAGDDLLHTRSWVSPDDVPANELPLAQSTIKVLSSMHSVLERTMEARDAELAKEASKPCGATSPEEQQKREHLRQTKAAEVRLVRNTKLLREPLTQFEVQVLRKEDVAIDRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5X4</accession>
    <name>A0A9W9X5X4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lytic polysaccharide monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000007">
        <property type="protein sequence ID" value="KAJ5483829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789099.1">
        <property type="nucleotide sequence ID" value="XM_056935631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5X4"/>
    <dbReference type="GeneID" id="81625880"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF2">
        <property type="entry name" value="LYTIC POLYSACCHARIDE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040974752" description="Lytic polysaccharide monooxygenase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5483829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="29782" checksum="6D1CE764A0E1FB55" modified="2023-11-08" version="1">MIIKQYLSLGVIALWAEAYLMVMEPEPYGKDSLNNSPLAADGSDFPCKLRPGAFEISGEATYRIGDDQVLKLEGSITHGGGSCQICLTEDRVPTKDSEWKVIKSFEGGCPANVKGQLVGGADSDNSLHLGFRIPEGIVPGQYTLAWTWFNRIGNREMYMNCAPITVIGNNQSVMAGEPNASFPPMFIANINGCNTTEMVAIRFPEPGNFVETPSDVISLASEDAPPCTGILTLHHGLNTKVTSAAASSEHSTAIITSTTLLAADPCVSNCSCRYNSHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5Z7</accession>
    <name>A0A9W9X5Z7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcriptional regulator family: Fungal Specific TF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_005076</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789872.1">
        <property type="nucleotide sequence ID" value="XM_056934678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5Z7"/>
    <dbReference type="GeneID" id="81624927"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF14">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="459"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5485088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="555" mass="61770" checksum="D5B5A355320BE76B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6X6</accession>
    <name>A0A9W9X6X6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_005468</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790264.1">
        <property type="nucleotide sequence ID" value="XM_056935070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6X6"/>
    <dbReference type="GeneID" id="81625319"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF37">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 10" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="518"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="591"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="120"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR002450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5485480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="707" mass="79282" checksum="F81E42F3F2A3973D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X755</accession>
    <name>A0A9W9X755_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790100.1">
        <property type="nucleotide sequence ID" value="XM_056934906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X755"/>
    <dbReference type="GeneID" id="81625155"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="88" mass="10212" checksum="C36CC131B0B14637" modified="2023-11-08" version="1">MGKGKQDSIGKLVAKQGFRVQMKQLGCESSPRVNLEERLHGVGGEKERRKNEDEKNEERGLWGREMKRRQEFEQMDPFQAPIDGTEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X771</accession>
    <name>A0A9W9X771_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Leukotriene A(4) hydrolase</fullName>
            <shortName evidence="16">LTA-4 hydrolase</shortName>
            <ecNumber evidence="16">3.3.2.10</ecNumber>
            <ecNumber evidence="16">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_005334</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA(4) but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B(4) as the product compared to the homologous mammalian enzyme (in vitro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>an epoxide + H2O = an ethanediol</text>
            <dbReference type="Rhea" id="RHEA:19037"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32955"/>
            <dbReference type="ChEBI" id="CHEBI:140594"/>
            <dbReference type="EC" id="3.3.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.10" evidence="16"/>
    <dbReference type="EC" id="3.4.11.-" evidence="16"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790130.1">
        <property type="nucleotide sequence ID" value="XM_056934936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X771"/>
    <dbReference type="GeneID" id="81625185"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000009">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.320:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000004">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012777">
        <property type="entry name" value="LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02411">
        <property type="entry name" value="leuko_A4_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 16" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="17">
        <location>
            <begin position="468"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="139"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="270"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="568"/>
            <end position="570"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5485346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="614" mass="69742" checksum="547614359BB8EA89" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7C1</accession>
    <name>A0A9W9X7C1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_005459</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790255.1">
        <property type="nucleotide sequence ID" value="XM_056935061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X7C1"/>
    <dbReference type="GeneID" id="81625310"/>
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</entry>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="239"/>
        </location>
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            <end position="565"/>
        </location>
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        </source>
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</entry>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1151" mass="127459" checksum="14C5A44DB4624F41" modified="2023-11-08" version="1"> </sequence>
</entry>
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    <accession>A0A9W9XCU8</accession>
    <name>A0A9W9XCU8_9EURO</name>
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        </submittedName>
    </protein>
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        </source>
    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
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            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790590.1">
        <property type="nucleotide sequence ID" value="XM_056933049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XD51"/>
    <dbReference type="GeneID" id="81623298"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5488557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="454" mass="50200" checksum="3BB98B7EB24FB40A" modified="2023-11-08" version="1">MSEKISYQESHWELPQTTRDAPTTRTASTAVPRSTFIRGLSIFLGALIIGNWLLRSHHCHDSHKRTVEERVQHILSQTPLIDGHNDLPIHVRSLFHNHINTPNFTKGFMEGTLPGHVDVPRLRQGQVGGTFWSVFVPCPANWEDLSDENYASSIRMTVEQVDLISRIQQAFPDILSPPPNGTTAMEAFRQGKLISPYGIEGLHSIGNSMAHLRMFHDLGVSYATLTHNCHNKYADAALVEQPDHTVKVATPLWHGVSPAGQKLISEMNRLGMIVDLAHVSADTMRDVLGAGKTHWAGSRAPIIFSHSSAYALCPHPRNVPDDVLKLVRERDSIVMVNFSPGFISCRASDREDGMPEDDDSHATLERVADHIMYIGEVAGFDHVGLGSDFDGIPTVPKGLEDVSKFPDLIAELLRRGVTDEQAAKIAGGNLLRVWKQVDQVALEMQAEGVLPEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDH4</accession>
    <name>A0A9W9XDH4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790891.1">
        <property type="nucleotide sequence ID" value="XM_056933350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDH4"/>
    <dbReference type="GeneID" id="81623599"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="223" mass="25244" checksum="A4CE26BE2DD67424" modified="2023-11-08" version="1">MTDSTKQKFGDEVEKVANAYGRLPLSHTSLDEAMRTRPDPGTVLAMMIDALVKSRPISHQVAESTVAGLIEDEYHDIDRLLGTTWEERTNRLRVVGYNRYREQCASNLGALCDLVLEKYDGDLNNLLEEAHEDREEVRTLVKEFKGIGELGAELFLDNVQSIWPSMAPFIDSRSLRTAEEIGLGNDVSAIYEQLQHDPLRMSTFVSGLSDIRLEHKQHEIDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE19</accession>
    <name>A0A9W9XE19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="13">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Exo-1,3-beta-glucanase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">N7539_004565</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. It could also function biosynthetically as a transglycosylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="13"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791708.1">
        <property type="nucleotide sequence ID" value="XM_056934167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XE19"/>
    <dbReference type="GeneID" id="81624416"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF1">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE I_II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040996041" description="glucan 1,3-beta-glucosidase" evidence="17">
        <location>
            <begin position="20"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="103"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ5489675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="411" mass="45940" checksum="4A2F41665D83C4CE" modified="2023-11-08" version="1">MRPLSPSLALLAFFHLALASPINTSSGSSCDPPSEKHKPGSTDDYINWRTFSGHGVNLGGWLEQESTIDTTWWSTYGANAADEWTICANLGPEECSRVFEARYRTFITTSDIDRLAGAGVSILRIPTTYAAWVRVPGSQLYSGHQQEYLRKVADHAIKKHGMHIILDLHSLPGGTNGLDIGEKVGNWGWWHNETALEWSLRAVDAVVAFVQSSTRPQSYTIEPINEPVDNRDFATFGTPAALSDLGAQWLLLYFREVIARVKKVNPRIPVMLQGSFQTEEFWSPHFEASENIVFDLHHYYFQFPQATSANVSTYICRDARASAGDGKFPTFVGEWAIETGGRNELALRGQNLQAGLSAWSQFTRGSTYWTAKFWNNATVVGEGIKQDYWNYEEMIAEGTFKGKSLIKDFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XED8</accession>
    <name>A0A9W9XED8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="3">FBP aldolase</shortName>
            <ecNumber evidence="3">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_004092</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791235.1">
        <property type="nucleotide sequence ID" value="XM_056933694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XED8"/>
    <dbReference type="GeneID" id="81623943"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050246">
        <property type="entry name" value="Class_II_FBP_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304:SF0">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE SUBUNIT GATY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5489202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="286" mass="31465" checksum="A990A070D2B7FEDA" modified="2023-11-08" version="1">MSLANNRALRILDHAAEHHYGVPAMCCYNVEGILATVRAAEAKRSPAMILLFPWAVHYADGILVHAAAEAARNASVPVTVHMDHAQTPEIIRRAADLKGFDSIMVDMSHYEKAENLALTRELVAYCHERGIATEAEPGRIEGGEDGIADTADLEGLLTTPEESQEFVDTGIDWLAPAFGNVHGEYGPRGIQLEYERLQSINQAVGKQVRLVLHGADPFTKEIFQKCIDCGVSKININKVLNNEYIKVQQEKAGKVPLTTLLEDATNAMQKAVERCMDMLESTGRYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XER5</accession>
    <name>A0A9W9XER5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_002448</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792010.1">
        <property type="nucleotide sequence ID" value="XM_056932051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XER5"/>
    <dbReference type="GeneID" id="81622300"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09264">
        <property type="entry name" value="AP_Syp1_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07650">
        <property type="entry name" value="F-BAR_Syp1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000102">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049609">
        <property type="entry name" value="Syp1-like_MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF54">
        <property type="entry name" value="SUPPRESSOR OF YEAST PROFILIN DELETION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD" evidence="4">
        <location>
            <begin position="604"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5490881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="897" mass="96613" checksum="C12C5CB07BE372EF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF34</accession>
    <name>A0A9W9XF34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_002581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792143.1">
        <property type="nucleotide sequence ID" value="XM_056932184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF34"/>
    <dbReference type="GeneID" id="81622433"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5491014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="119" mass="13724" checksum="D5AF978B69E2D06D" modified="2023-11-08" version="1">MMRWQRRGVQKFSAAPNQWDTRRNVEYVPSFPHDRSKTTYLFRDSSFQLGVAMVHCANVQHRTPLMKRCDTGFGRGNNTTLGEMPQLDRKIDPSDIAVPTLMQWATQSTIYMTTGLPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF36</accession>
    <name>A0A9W9XF36_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_004588</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5489698.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056934190.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81624439"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 3"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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            <begin position="25"/>
            <end position="347"/>
        </location>
    </feature>
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            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="DSC E3 ubiquitin ligase complex subunit 3 ubiquitin-like" evidence="4">
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            <begin position="16"/>
            <end position="146"/>
        </location>
    </feature>
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        <location>
            <begin position="208"/>
            <end position="344"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="289"/>
        </location>
    </feature>
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        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
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            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="268"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10302"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13373"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5489698.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="37065" checksum="E88F948E81227110" modified="2023-11-08" version="1">MAFQSWLSPSSALDLLVIVRFSASIPDLNLDVPNAESTTGAGLKQLIRAKLPPTLKNHRLRLIYAGRGLEDTTALAVSLKLPPSPSRTPRPADEDEDEQDQGADHDDDDGEPSTAEQSLLRRKRKGKQPVRDTRPRLYIHCSIGDIALSETDLAAEAAVASTQLLEKQKDASQVSMLARNNDSTSRSTDASQSQSQPAQHSSTTPAPRGFDRLLAAGFTPAEVTALRSQFLAVQSVSRTRDTMPTGDELRDLEDRWMDEGSTVAQAQAGGGLGGAGGGGGGDDDGGFGSGSPTAIDDMLWGAVMGFFWPIGCAFWLRNEGVWSWRKGMAVVAGLIVNAVFGGFRIMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFQ1</accession>
    <name>A0A9W9XFQ1_9EURO</name>
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        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_002314</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
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    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sondergaard T.E."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF79">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <location>
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            <end position="72"/>
        </location>
    </feature>
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        </location>
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        <location>
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            <end position="27"/>
        </location>
    </feature>
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        <location>
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            <end position="93"/>
        </location>
    </feature>
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            <end position="281"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="937"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5490747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1119" mass="123370" checksum="DF975C1D451F96C3" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG10</accession>
    <name>A0A9W9XG10_9EURO</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9W9XG46_9EURO</name>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Frisvad J.C."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9W9XGP8_9EURO</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
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                <person name="Frisvad J.C."/>
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            </authorList>
            <dbReference type="PubMed" id="36726175"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHJ2</accession>
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        </submittedName>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <comment type="caution">
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        <property type="protein sequence ID" value="KAJ5491722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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            <dbReference type="EMBL" id="KAJ5491722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
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    </evidence>
    <sequence length="87" mass="12676" checksum="221EB2AD165B4B88" modified="2023-11-08" version="1">MRISATIARQRSYRRQTQHYYYYYYYYDYYDYYYYYYYYYYYYYYYYYYYYYYDYYYDYYYYYYYYYYYHHHHHQVRSLHLRLFEFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHL5</accession>
    <name>A0A9W9XHL5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001887</name>
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    <organism evidence="2 3">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793521.1">
        <property type="nucleotide sequence ID" value="XM_056931490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHL5"/>
    <dbReference type="GeneID" id="81621739"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="83" mass="9427" checksum="4CF92D13D33239B2" modified="2023-11-08" version="1">MSDVIRHHLRSDVKLHPPPTIRIKTKSRIPPPPSRRQDSPLPFFSTIAPPFLDMTTPCIGDLRNGDNHSAEWCTTTHWTADTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHZ5</accession>
    <name>A0A9W9XHZ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_002099</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056931702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHZ5"/>
    <dbReference type="GeneID" id="81621951"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
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        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF215">
        <property type="entry name" value="DYNAMIN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
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        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="31"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="649"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="420"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5493353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="737" mass="82561" checksum="02A33D4E8AD5F238" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI56</accession>
    <name>A0A9W9XI56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein RTM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_001560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056931163.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81621412"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5492814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="230" mass="26405" checksum="03CAD5FD7CEAC6B1" modified="2023-11-08" version="1">MGWVHWPNLVEHREPRLDDGPIYPSDMTAVTGPHIIRRFDIYDAGENYGASSSRKSLPLQEKMAHKDFSSHCSLIRITSHQWARAYMEYIGGGVMAGDSLSAVHNGEEIVIAGLVIQIFFFGLFIITCALFHKRVRKFPTARSLELSRTWRKYLHILYTANLLIVIRSIFRLIEYAMGNNGYILRYEVFLYVFDGLLMLLVMVLFNVVHPSGLISHKSDKTRRTEMNALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI77</accession>
    <name>A0A9W9XI77_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793224.1">
        <property type="nucleotide sequence ID" value="XM_056931193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XI77"/>
    <dbReference type="GeneID" id="81621442"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000030">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000778">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF6">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="99"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="413" mass="45556" checksum="9E69F5D485F54B47" modified="2023-11-08" version="1">MAPPSVLMVGTGEYTTGFVGGGASGSDKKVGVVGLTMFDLRRRGKVGDLSMVGVSGKKYPGIRDHLHRNICQVYNGLDTSFTSYPADDQTDPDAYKTAIDALPKGSAITIFTPDSTHFPIALYAIERGHHVLITKPATQRLEDHLTLVEAAHKAGVFVFVEHHKRFDPAYSDARAKARSLGDFNYFYSYMSQPKSQLETFKAWAGRDSDISYYLNSHHIDICESMVPEYTPVRVTATASQGTAAAVGCVPETEDTITLLVEWRKKDDPSKIATGVYTASWTAPLNAGVHSNQYFHYMAANGEIRVNQAKRGYDVTSDEQGLMWYNPFYMRYAPDEEGNFAGQTGYGYISFEKFIDAVTAVNEGRVTLDQLDARPLPTLKNTIGTTAILDAGRKSLDERRPVDIICDGGKWQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIJ1</accession>
    <name>A0A9W9XIJ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793555.1">
        <property type="nucleotide sequence ID" value="XM_056931524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIJ1"/>
    <dbReference type="GeneID" id="81621773"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42023">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42023:SF1">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="397"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5493175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="54198" checksum="20D26FE54F0E9CBE" modified="2023-11-08" version="1">MWSKAPFRSRQPIDNSTEAGTTSAYQMQSSAKIPLSNQPVKRLPRLPHEPTAPATGPYDATAVPPSRKSSVGEEDSSVSPAISPMLSLRTRDSEESFCVSSMGDDDDHNQEYSYETPSAFNPLNPGRGAPEPFLAVHSRPSRERLQLSQGTPQPPHLSSAAPKQPVPAGLNAANDPSRGVAGWQNQAPPRSAAFHKSSGSHTTNLFSWGREQFQPRNKHERARGRMLSRSRNEIDSSPYGQRSMSQNKPPAQHARRDTISPPQDTNLGFVPTVVTTITAGAPELLPEPLPPINTEEDFLFPTEPQSTQPAVPGIAMNPRNEIYNNLSDSSHEDRAAEPEATDGRTSSIMSRRRPIPIAMPTSKKPVRKPIPSKTSPTSTMATQLQPSDGPKDTLSRIEALETRRDELAKRRFNLETVIHELTRVIQPTSTIYDQAAKAEVKRSVQSIENEIAEIKREEHELGLKATRAWRKLDERENHGDGSNLWVKRVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XL03</accession>
    <name>A0A9W9XL03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_000025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793922.1">
        <property type="nucleotide sequence ID" value="XM_056929629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XL03"/>
    <dbReference type="GeneID" id="81619878"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5494909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31572" checksum="4251B397E5FA8747" modified="2023-11-08" version="1">MITFLGLLFDFPPIIERMIHAYNLSVSGFEEVDEEMENVPSIASLPNRILKEAAAAFGSIKVFNSLLTRCPLSLPHPGARGFNLAFYLAHFTFQPEILKVFLDLGFKPNLFPYMFDDPPDWVVLVGPRESSIIIRPLESISTPRVLATIRLLIDYGADVNQLSSSGTTALWSAVAMYESQEIFEDLLRHGADPLAGSDPSLTALHSAITSRDFNLVRLFLEALSLRGRPLEHASFFLDAARVECEDNDDICGARISAAASVLRVPTHYHWRQIYPVPADPPSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XL57</accession>
    <name>A0A9W9XL57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Non-specific serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_000009</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793906.1">
        <property type="nucleotide sequence ID" value="XM_056929613.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81619862"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000030">
        <property type="entry name" value="Histone acetylase complex subunit Paf400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="3305"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5494893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Penicillium diatomitis</name>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">IBT 30728</strain>
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    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMD0</accession>
    <name>A0A9W9XMD0_9EURO</name>
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        </submittedName>
    </protein>
    <gene>
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        <dbReference type="NCBI Taxonomy" id="2819901"/>
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            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="match status" value="5"/>
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    </dbReference>
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        <location>
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            <end position="262"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5494929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="287" mass="31711" checksum="D4CA5627B501AF10" modified="2023-11-08" version="1">MDVLPPPDYPPVQPSDYPQIPTRTPPATLEVLRASCVRGDIQKFREILESQSSSSEGFDICDFYAIMIEAIKRDDVQFIKELLVRGLPMDPLYALEAVNANAKDALEVFLKNGWNINQPMSELKPPVLGYAIADEEMVAWLLDHGADPNRQCVIDLTPLSLAVESAPVSVIQLMLSRGGDVRKGQLLHHAIERHSDNIAVLSLLLGKGAPINSTRYEDHYPSRALFSFMDLGTPLHKAAELGKADVVRYLVSKGANLNGKDAKGRTALEYARMLDQREVTHALEKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ30</accession>
    <name>A0A9X0BJ30_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_009574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785664.1">
        <property type="nucleotide sequence ID" value="XM_056939169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJ30"/>
    <dbReference type="GeneID" id="81629419"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5466618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="326" mass="37684" checksum="1CBEEC658C7F5FAA" modified="2023-11-08" version="1">MEFPVSTTRPRWERDAGQVTTSVRPNLGEQRDLIRQSVTNIISVLRTFSLMTMKIDDLLRFNIEITEFDPLNPLDHTIFQPMPVSEFSKYELEQELFHGLMTDNVKLTDLELPDPASNSASRLDIERAAMRESQRLYRYIDLLYTCHSQIEEPNDPISMAVGWISIPVPLPQYTWPRELGPNSWPRDHGMLSHDLGPEHVGWKCEMVSEWKDRSGRTTKVWPHVRMAVCHGHSGDPHGILIGELGAIAQVILNRLNQPQFDNESYFPVLMLSFFGPRHMRFLQAVYRPAGYLELRASQIFDFTTLAVSRLDLMLEYLACSPRRDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJJ2</accession>
    <name>A0A9X0BJJ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_009258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786230.1">
        <property type="nucleotide sequence ID" value="XM_056938853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJJ2"/>
    <dbReference type="GeneID" id="81629103"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="117"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5469640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="370" mass="41368" checksum="2DBC3F5D119DB075" modified="2023-11-08" version="1">MTSAPADVSVKVLPWATFAYLQPKNRQDPKWTYRQALVNTILKVCLHKYCTFHKGSSQVSLKPGLERSRFVLIDPARSDLYNGVAYSQVTSPEIVGATWYPRRPSRDFVIPHDQHIMLHFHGGSYIVGDGRISSCGFLAKHMLAHTPSQYVLSVQYRLTGPPNGRFPAQLQDAISAYFYLLDSLHIPASQIILCGDSAGANLALGLLRYITNFDNSTLLPAPKCALLLSPWTNIPEAVDTEAWDRSANYKTEYVPASFPARGATLLLHDLEITKSVEEQIAPIKHPFSLPAPILVVTGGKEVLCEENRAFAQTYKSFGHNEAMVDLYVSEPTPHDLFMIGWIMGFQKEARECAEVAGTFIRQFNVQRNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BLR9</accession>
    <name>A0A9X0BLR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786440.1">
        <property type="nucleotide sequence ID" value="XM_056938432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BLR9"/>
    <dbReference type="GeneID" id="81628682"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5471894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="381" mass="43258" checksum="2380EA43152EA19A" modified="2023-11-08" version="1" fragment="single">DIVGIIILPADPLSINTLSRFTGIGTDQISNRLDSFRSVLSIPGDRDQPVRILHLSFRDFLVRSSSKFLVDERRKHKEIAHCCLKTMQSHLRKDICNLANPRAQKADNPQDTRQYLPPELQYSCRYWIHHLKQSQDLSSGIEDVLLFLQKHFLHWLEAMSLLGLISEVVGMLDLLHTVKLRDDNPVISDFLHDGTRFVLKNRQIANEAPLQIYYAGLVFTTRTTIIRREFKSELPGWICQFPQVNEKWSAELQTLEGHSSWVHSVAFSPDGRLLASTATGGLQETLTTKGIVNKLDFSQDGSYLITNLGTLDVQSGHKYLASNSTHKNRAIFIEQGRWINMNGKNVLWLSPDFRPTCSAINGDSLALGHESGRVSFLRFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BLT7</accession>
    <name>A0A9X0BLT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zona occludens toxin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786647.1">
        <property type="nucleotide sequence ID" value="XM_056938265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BLT7"/>
    <dbReference type="GeneID" id="81628515"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5472101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="51864" checksum="20770030A316A143" modified="2023-11-08" version="1">MLELDGSDGQSDEALLAPVLTGAVLNRPSLGPTQYGLLGGVKRIDTPSYSTMNDEVTKNDPRLFFNVSSPSSVFICGSQGTGKSHTLSCLLEGCLIPSKAGRLLSPLTAVVFHYDTFICDGGGSPCEAAFLSSHPDLKVRVLCAPTNLRTIKGTYSRFNIEVQPLQIDQSHLNTKRMLDLMSVARDSGAGPLYLQTVQRILREMRLLQQSTGLPFDYQDFKTRILGSGLLTGQLEPLKQRLDILESFMPPHQASTGYKFKKTKAKSQDGGSNWAPKLTIVDLSCPCVSPDTACSLFNICFEIFMEQDTNIGRIVALDEAHKNLSKPRNFTDTLLSTVRLQRHLGARIFVSTQEPTISSDLLDLCSVAIVHRFSSPAWVRALQSHVAAAALNLHVTKDSQAKNEQALLDIPAKLSIFHRIVNLKVGEALLFSPGAMLSIVSEEPELQDMVRLGSGYMTIKVRGRLTEDGGKSVLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNW3</accession>
    <name>A0A9X0BNW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Argonaute linker 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787415.1">
        <property type="nucleotide sequence ID" value="XM_056937550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNW3"/>
    <dbReference type="GeneID" id="81627799"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Argonaute linker 1" evidence="2">
        <location>
            <begin position="473"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5475662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="750" mass="81717" checksum="A3FB721EC24602FA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BPB3</accession>
    <name>A0A9X0BPB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">molybdopterin adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_007435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenylyl-molybdopterin + molybdate = Mo-molybdopterin + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>molybdopterin + ATP + H(+) = adenylyl-molybdopterin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:31331"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the MoeA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.75" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787835.1">
        <property type="nucleotide sequence ID" value="XM_056937036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BPB3"/>
    <dbReference type="GeneID" id="81627285"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061598">
        <property type="term" value="F:molybdopterin adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="entry name" value="MoeA, C-terminal, domain IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.10">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.190.11">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192:SF30">
        <property type="entry name" value="MOLYBDOPTERIN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="MOLYBDOPTERIN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="MoeA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="MoeA N-terminal region -like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="4">
        <location>
            <begin position="201"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5477291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="449" mass="49051" checksum="241714145D208B0E" modified="2023-11-08" version="1">MTLSYSEAIDLLRSQAQLHKADRKEQIPLNLAVNRISSNTLCAAHSTPLWDTSAMDGYAVCSQVTKLASPQNPIMIPVVGLIAAGKQPILTDPLPGPRSPFCVEIMTGARFPDPHTTVGVELDACVKFEDVHKIQDQVTGQHWIKVTKPVVSQQNRRLAGHDFRQDQVIISAGERIRPRHVMALASVGIHQIWVQKRLQIGLYSTGSELLSRSRENDDQQNKLQIQDVNGPYLVAALSDGIDADVRFLGILDDHADTITDRITQDVISSSLDLVISTGAVSAGRFDLIPTALEALHAKILFHKLNIRPGHPALAALVPSMTGEKRSTPFFGLPGNPVASAACLRFLVMPFIRFLGSEAVDTPLKASLTRTDKENTEQASHIVTALPIDKDVFRPGILTHDSQGRAEVTLIADHSPGKVSPFLRGNCWIHFHTSQQEVCRGDVVDVYPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BPE4</accession>
    <name>A0A9X0BPE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Leucine Rich Repeat domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_007676</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788076.1">
        <property type="nucleotide sequence ID" value="XM_056937277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BPE4"/>
    <dbReference type="GeneID" id="81627526"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000273">
        <property type="entry name" value="Leucine Rich Repeat domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="612"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="688"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="618"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="693"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5477532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="801" mass="86908" checksum="E4526BC12D6E1FFA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSH3</accession>
    <name>A0A9X0BSH3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription elongation factor SPT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_006651</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788187.1">
        <property type="nucleotide sequence ID" value="XM_056936252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSH3"/>
    <dbReference type="GeneID" id="81626501"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06082">
        <property type="entry name" value="KOW_Spt5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06083">
        <property type="entry name" value="KOW_Spt5_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000018">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000029">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.940:FF:000005">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041975">
        <property type="entry name" value="KOW_Spt5_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041976">
        <property type="entry name" value="KOW_Spt5_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024945">
        <property type="entry name" value="Spt5_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022581">
        <property type="entry name" value="Spt5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017071">
        <property type="entry name" value="TF_Spt5_eukaryote"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12815">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23042">
        <property type="entry name" value="KOW1_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23284">
        <property type="entry name" value="KOW2_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11942">
        <property type="entry name" value="Spt5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036945">
        <property type="entry name" value="Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01104">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="KOW" evidence="11">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="11">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="11">
        <location>
            <begin position="514"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="11">
        <location>
            <begin position="637"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="11">
        <location>
            <begin position="728"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="Spt5 C-terminal" evidence="12">
        <location>
            <begin position="863"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="713"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="879"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="55"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="978"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1017"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1047"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5480757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1058" mass="116084" checksum="BDF3E41D6139C192" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSN0</accession>
    <name>A0A9X0BSN0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome monooxygenase xanG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_007027</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788563.1">
        <property type="nucleotide sequence ID" value="XM_056936628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSN0"/>
    <dbReference type="GeneID" id="81626877"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11070">
        <property type="entry name" value="CYP56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF223">
        <property type="entry name" value="CYTOCHROME P450-DIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5481133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="503" mass="57998" checksum="68B43C5A1C51976F" modified="2023-11-08" version="1">MYHWILGQITWPRGILGLILVTLIALYWFTRVPGSMPRNIPTVPIYISLLGLWSDMGQDDIYDRWLREPLERYGAVKIWFAGRWNVLATRPSFLVDMFRHEDVYAKAGSQKKIPWSVIASLVGDNIINSHGETWRLYTSIMKPGLQRRITDSRPLLEKSRKFVDIILEEQQILGPGRGVLVNPIIQRWAISCMGIHFMDVDLEAIERPGQRLEVLQTIIKKTLFHPLFFNFPQLDRYPYIFRQRKVAFGIMQEFGDLLCETVKQRPSHDETADGDQVVDYLDRALKEGRITEEQYRANLKVTFLTAHENTQQLLNSTFWVLGQNQDIQQRLRAEILATGEEDPSTELVHSLPYLFAVILELLRLYPPVSQLINRVTTSVAVLGGKVAIPNHTWVGWNAFGVHTDPSVWGSDAREFNPDRWGKDVKSIQSTLRSKTTQCHFIAFNAHSRKCLGQGFAVLQMKILLFEMLRRIEWTVDPQYEFKLTSGGIMAPLGLRAVINERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSY5</accession>
    <name>A0A9X0BSY5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_006453</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788979.1">
        <property type="nucleotide sequence ID" value="XM_056936055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSY5"/>
    <dbReference type="GeneID" id="81626304"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902369">
        <property type="term" value="P:negative regulation of RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013633">
        <property type="entry name" value="NRDE-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471:SF0">
        <property type="entry name" value="NUCLEAR EXOSOME REGULATOR NRDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08424">
        <property type="entry name" value="NRDE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5483007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1257" mass="143003" checksum="DC25079263BFBCCD" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BT33</accession>
    <name>A0A9X0BT33_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788696.1">
        <property type="nucleotide sequence ID" value="XM_056935772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BT33"/>
    <dbReference type="GeneID" id="81626021"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5482724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="586" mass="62501" checksum="75074E0940ED90AF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BTU6</accession>
    <name>A0A9X0BTU6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Protein phosphatase methylesterase 1</fullName>
            <shortName evidence="7">PME-1</shortName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_005778</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789252.1">
        <property type="nucleotide sequence ID" value="XM_056935380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BTU6"/>
    <dbReference type="GeneID" id="81625629"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051723">
        <property type="term" value="F:protein methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000186">
        <property type="entry name" value="Protein phosphatase methylesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022950">
        <property type="entry name" value="PPase_methylesterase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="10">
        <location>
            <begin position="107"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR022950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR022950-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5483982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="429" mass="46581" checksum="2DB2B9D8A4A7FC86" modified="2023-11-08" version="1">MSELQKSFAKAKLAKLPAEAPMYNPMKIPEENTEDDASSASSVSSTGTLMPSPTRNLFARRSASQPMQAHTWPEYFSQELFLPEEVHGMRIVHHAYLTPPSGSGPLFVMHHGAGSSGLSFAACAEALRRILPNAGILSLDARSHGQTVTSPITQVLNQEHPSTAAAAQAEVESQIELDLSLDTLSRDLVFVVQETQTKMGWKALPDIVLVGHSLGGAVITDVAKKGALGPKLLAYAVLDVVEASLTGSAMDALQSMETYLSTRPTRFTSLASGIEWHTRSRTIRNSTSAQASVPSLIYEESDPADPSRPWVWRTNLSATKPFWENWFIGLSRKFLDSRGGKLLLLAGTDRLDKELMIGQMQGKYQLQVFPEAGHFIQEDQPAKTAQVLADFYRRNDRSALVLPPKVGDLQAAAAMKKGAGSLDKTGTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUN2</accession>
    <name>A0A9X0BUN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Type I iterative polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_005342</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790138.1">
        <property type="nucleotide sequence ID" value="XM_056934944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUN2"/>
    <dbReference type="GeneID" id="81625193"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="374"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5485354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="485" mass="52982" checksum="25AADF54B5B565B2" modified="2023-11-08" version="1">MAMIVYWLEDEYVPVSVQQISQRDDLFRPDRTYWLAGLAGDTGRSLADFMIAHQALNIVLSSRRPVVDEAWVLSQKAKGATVRYFEGDVTCFSSMKKIHDTIKESMPPIGGVANGAMVLRDSSFMNMSFEDFQTVLRPKVQCTINLDRLFSDRSQPLDWFIGFSSIAATVGLIDRRRQQGLAGSVIDITRLVGLGFIERESRGWGLTKEHQERLTTRSGTIAMSENDLHQLFAEAILSGRPALGLNPEIITGLAPITVEQSKDAYWKTNMRLSLLIKDAGQGNAQGSERSEVIPSRKLLEGAKSLQDAVKVLWNSFKKKLQALKFLSDSDGIYDSTPLVYMGVDIMKILGGASIADLVEIVASKLPDELLNRLDPEGKQRTGNAGLSEATVSSLVSPTEPTVDHVENDHHLASPDGVNGIVGTNGVKYENGDDAENSGLKGINEIKGAHIAGAGTNGATNIVEKDSEYATKDTNSSIIIREQEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUX0</accession>
    <name>A0A9X0BUX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790408.1">
        <property type="nucleotide sequence ID" value="XM_056935214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUX0"/>
    <dbReference type="GeneID" id="81625463"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="455" mass="52076" checksum="42AE148D1A961F51" modified="2023-11-08" version="1">MQPIPFINRASKTRACPDNATRAAPSSRCSSRGRVKVSDHEKRSVLLPSRDSLTDIRVECRESPKTTKGIHTPVRDGGCHEDDGDDDVDEPKEEEEEEEEEEEEEEEEEEEEEEEEEEEEVETPRCLKRKRAGSPSVVITPLTWSPSTPVVNKSNWTKKSTVSPIKVGKCRTWLDSPVSDDQLTCFPSKIKRIRGSTDHQDTSDCKNTETQFLVAELAALRADLFSERQVLHEIKRQAARDTSDIVSLRADFEALRSQLTAEDESKVHFSSFQDELLALRADLEVLRCGGSNEKSAPTSPDDAEKTITDQAKIDEIIHLNELLRRVLQGERIYTEQMHKKLHSLRKKVGPLLAKVDTLQGSLDEIKTQYSAHDAPIELIMDFVRMFHSWWVDRYNVRQGSRNGQVVEKEKEKEKEKEKKKEKEKEKEKEKEKEKEKEKEKEKEKGKGKVSQRGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BV04</accession>
    <name>A0A9X0BV04_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_005374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790170.1">
        <property type="nucleotide sequence ID" value="XM_056934976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BV04"/>
    <dbReference type="GeneID" id="81625225"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050218">
        <property type="term" value="F:propionate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347:SF3">
        <property type="entry name" value="ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="4">
        <location>
            <begin position="11"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="77"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="558"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5485386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="701" mass="76146" checksum="D286243823ED76B8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXL0</accession>
    <name>A0A9X0BXL0_9EURO</name>
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            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">N7539_003484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5488594.1"/>
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    </dbReference>
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        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 5"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00004">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <location>
            <begin position="492"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
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        <location>
            <begin position="1011"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5488594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1085" mass="121317" checksum="E93A5BE2EA03D528" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        </source>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="115"/>
        </location>
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        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
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            <dbReference type="EMBL" id="KAJ5488936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXU4</accession>
    <name>A0A9X0BXU4_9EURO</name>
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        </submittedName>
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    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
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    <dbReference type="GeneID" id="81623439"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5488698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="166" mass="19176" checksum="76AF15221AE09349" modified="2023-11-08" version="1">MSPNLFLCLRTLFCPTYWFQKGERIDGNVKREQHWDSPVPGTYKFLPGKGWHLIKRDDSDHQEKVPQAIVYCRILHRYMFETELNDRCRWYSAPLHRGAAPEELRFFLLDDGIHWVAGWDAQGRFIPGPYPKWYLDEDGVTMHRGASPCSSATVSRCSSVIAGKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXX3</accession>
    <name>A0A9X0BXX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_003814</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_056933416.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF19">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
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        </source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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</entry>
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        </submittedName>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
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                <person name="Frisvad J.C."/>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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</entry>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="141" mass="15486" checksum="1C22D18B45748C99" modified="2023-11-08" version="1">MAMLKEVNEEPLIFATVVRPGVLRSEVLYEPSGEEALDQESRKVAATDVLISFGRYFVFRRIHSSSWFGLDPEPGHLCDCPAVESDYELLGTLDTGLERKIKIVWSATGETAGVNPRCTSTDANAKTVLRLAAIDSKPDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY93</accession>
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            <fullName evidence="2">UBL3-like ubiquitin domain-containing protein</fullName>
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    <organism evidence="3 4">
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    <reference evidence="3" key="1">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="3" key="2">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_056933640.1"/>
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    <dbReference type="GeneID" id="81623889"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ubiquitin-like_domsf"/>
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    <dbReference type="InterPro" id="IPR040015">
        <property type="entry name" value="UBL3-like"/>
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    <dbReference type="InterPro" id="IPR039540">
        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
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        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13881">
        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBL3-like ubiquitin" evidence="2">
        <location>
            <begin position="206"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="303" mass="31992" checksum="FD155BAC9D3AA3D1" modified="2023-11-08" version="1">MSSTDHPESGVADSSNALESGATTTTPQLSAHPEHDTTKSTAPSPVTSDTVAHVEPSPTSSAAAPQPSSEENAAATAPQHPATGGEPVDPIAATAATTPATDTVQSPAHDTANTSISTSQPPADTAATPAALPSSAESPSMESHEPKATAEPSSDPSEVEEGKETEHAGPALMITLLLTTGSRHPFTIDTKYLRKQSVSVENDDPFAMSVYTLKELIWREWRSDWETRPSSPSAIRLISFGKLLDDKSPLSDSRFSADHPNVVHMTVKPQEIIDEEDAKGAKSHMSREREASERSPGCRCIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ98</accession>
    <name>A0A9X0BZ98_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_002620</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792182.1">
        <property type="nucleotide sequence ID" value="XM_056932223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ98"/>
    <dbReference type="GeneID" id="81622472"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000023">
        <property type="entry name" value="Threonyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000039">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF50">
        <property type="entry name" value="THREONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="87"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5491053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="527" mass="59183" checksum="EB58872D5A34271E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZN9</accession>
    <name>A0A9X0BZN9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_001354</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792988.1">
        <property type="nucleotide sequence ID" value="XM_056930957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZN9"/>
    <dbReference type="GeneID" id="81621206"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="79"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="170"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="731"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="743"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="799"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5492608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="890" mass="99261" checksum="416F02A615535B8C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C000</accession>
    <name>A0A9X0C000_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_003294</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="11">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792855.1">
        <property type="nucleotide sequence ID" value="XM_056932896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C000"/>
    <dbReference type="GeneID" id="81623145"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000038">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000295">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="12">
        <location>
            <begin position="29"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="135"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5491727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="366" mass="39712" checksum="DA77DA3DF80FD67A" modified="2023-11-08" version="1">MIAIGMEGSANKLGVGIMLHPEDGSPPRVLANIRHTYVSPPGEGFLPKDTARHHRAWVVKLVKKSLKEAQVSVADVDCICFTKGPGMGAPLQSVVVAARMLSLLWNKPLVGVNHCVGHIEMGRLITGATNPVVLYVSGGNTQVIAYSSQRYRIFGETLDIAVGNCLDRFARTLHISNDPAPGYNIEQLAKQGKQLVDLPYVVKGMDVSFSGLLAAIDGLAAQWDLGGEDAANEDLRAQDPQSDAVHIPQTDGKPTRADLCFSLQETVFAMLVEITERAMAHVGSKQVLIVGGVGSNERLQEMMGVMARDRGGSVYATDERFCIDNGIMIAQAGMLAYQTGFQTPLKESTCTQRFRTDEVFVEWRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C1V7</accession>
    <name>A0A9X0C1V7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_000109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794006.1">
        <property type="nucleotide sequence ID" value="XM_056929713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C1V7"/>
    <dbReference type="GeneID" id="81619962"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5494993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="76" mass="8495" checksum="7E21BDECD5C3EFB1" modified="2023-11-08" version="1">MHATLAVVLAYDRYSNSSSESRRTLRSKTLFNMQLSRRTIRAHRKDTIWGTAAAPVVLTIATPEARAPAKTWPLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2E5</accession>
    <name>A0A9X0C2E5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arginine permease CAN1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_000694</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794591.1">
        <property type="nucleotide sequence ID" value="XM_056930298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2E5"/>
    <dbReference type="GeneID" id="81620547"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="58"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5495578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="559" mass="61100" checksum="D5AE5B2A408B7372" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2L3</accession>
    <name>A0A9X0C2L3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA N(6)-methyladenine demethylase</fullName>
            <ecNumber evidence="2">1.14.11.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_000889</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an N(6)-methyladenosine in mRNA + 2-oxoglutarate + O2 = an adenosine in mRNA + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:49520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="1.14.11.53"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:49521"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.53" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794786.1">
        <property type="nucleotide sequence ID" value="XM_056930493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2L3"/>
    <dbReference type="GeneID" id="81620742"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990931">
        <property type="term" value="F:mRNA N6-methyladenosine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000014">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557:SF2">
        <property type="entry name" value="NUCLEIC ACID DIOXYGENASE ALKBH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="10">
        <location>
            <begin position="249"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604574-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5495773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="375" mass="42220" checksum="80A25DECB12235C8" modified="2023-11-08" version="1">MAQIKELNAHERPPEAVRQCYKRYSRITVAEIDHAPGVLDLQRLDEANLPAGVSVSQYMSSQDLRLAFDDFIQGQDARNVKHAPQAENIPVFTHDAVSGQHSTRSREPRKTNLLRLQSNLTPDRPLDDPGALPPTIQTELLSRLLHRDLPNPNHKTNLHLHYDVTYPTTCPESEARPSFFADDSTRMIQPKDPQVHKPMSIHSVLEKKLRWVTLGGQYDWTAKVYPAEPPPPFPQDVAKLLKAAFPQTDAQAAILNLYSPGDTLSAHRDVSEDCDVGLISVSFGCDGLFLISHDDGNGAEVIRLRSGDAVYMDGTSRFAWHGVPKILPNTCPSWLSDWPCPDEASTEFENQYQMWKGWMSRKRINLNVRQMTFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C300</accession>
    <name>A0A9X0C300_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_000710</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794607.1">
        <property type="nucleotide sequence ID" value="XM_056930314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C300"/>
    <dbReference type="GeneID" id="81620563"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000004">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF171">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="31"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="268"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="571"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5495594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="909" mass="102124" checksum="4AEDB8BA0F9D65CD" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C325</accession>
    <name>A0A9X0C325_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytoplasmic 60S subunit biogenesis factor REI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_000785</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the REI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794682.1">
        <property type="nucleotide sequence ID" value="XM_056930389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C325"/>
    <dbReference type="GeneID" id="81620638"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="98"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="270"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5495669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="445" mass="50633" checksum="D1817CC0B106CA48" modified="2023-11-08" version="1">MSTTTQQGSGAAANLPYTCNTCLVAFHRSDAQRDHMRKDWHLYNMKRRIASLPPVALEVFNEKVLAAKANSTQAAAKASFEKTCHPCQKTFYSENSYQNHVKSSKHKQREHRLRKDGDDASVVSSAFSMGEPVSKSNETDVAKVTSGLQSTTIQEEDGDVEMRTDKTEFSVARCLFCLNESADVKSNVEHMYKTHGMFVPEQDYLVDLDGLLNYLYRKITENHECLYCHAIRNNAEGARTHMRDKGHCMIAFEAEEEQIEIGQYYDFRSTYSDGEEDDEDEDMAESGGVKVKSDGDDDGWETDASSVDEDGEIDTRRKAPLVYQDEYELHLPSGRSVGHRSLAKYYRQNLDKYPTPEERLEHQLAIANGEIDENEKPRGRNQNRALITRANGGTGMIGVGEHAREKVRSAERRERTRALRAENRYLARIQRANNSQKHFRDPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C3E5</accession>
    <name>A0A9X0C3E5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED19</name>
        <name evidence="11" type="ORF">N7539_001221</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C3E5"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013942">
        <property type="entry name" value="Mediator_Med19_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08633">
        <property type="entry name" value="Rox3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="350"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5496105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="467" mass="49385" checksum="3DBF8E78B53EFD6B" modified="2023-11-08" version="1">MSDRTPAITFPAGPLSPPSPAAGSSSASKESQHLPPFLNHAPQTPTSPPLMSVSDSNNGSNFTSTQAPSNQATVHHHSSHGSSPYSSTPVSTQASQPPTLSTTNSFPTPASSVSGHLTHATSFEEPDLKALQPGTQAATSTMNPGSEPQTADYMHTDHDRQPIFPSSTASGLCDGAADKKPDPDAMDVDQEPILRSGTHGLGLDSLQKDFQSAYHLCKSSPIPTGPDPSWDLISLYGLGSIAQSVARIHPVTGEKINRLRKSYEGKLKPLGLAGKNKPIKTDSSKEGSLRYLTLWPEEEWQNQKVFGKQIKTADMDSALLGLQTKAMQLQPGVAPNNDFWEDVLGLEKPVKVSGPGDMGKKGTPTPGGRLGTQPMVASGAGATDLGDRARPSRGRKRNYDDNSFVGYGEGYADDDDETGFYSNGEGAGKKKRKKVGVAYLDHVSKVSTPMSERSGSYGVGMFGIGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C3F4</accession>
    <name>A0A9X0C3F4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795087.1">
        <property type="nucleotide sequence ID" value="XM_056930794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C3F4"/>
    <dbReference type="GeneID" id="81621043"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="26"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5496074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="315" mass="35108" checksum="20C08551FB8F8404" modified="2023-11-08" version="1">MSVEEGSHTLPDETELYTKTWKSEGSPKAILALVHGFSDHCNAYYDLFPTLASNGIEVRAFDQRGWGRSFKGRKDRGNSGGTALVLSDLHSFLRAIPVPPNVPLFVMGHSMGGGEVLNYVLHPDSPYNQSTARPQLAGVLCYSPLIALDPATRPMAFTVIMGRLVARVLPKWQRYSPLDGSLICRDEQVVKDYTSDELCHNTGTLEQLAGMLDRGIWLEKLKEEDLKNTEVLPMWFGHGNGDRITSWDATKKLASVLEKKGDVTFVTYEGGYHRVHMDPGETREQFSKDVSDWVLKQASTYSQPQPEAEPQPVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL95</accession>
    <name>A0A9W9WL95_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_009158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786130.1">
        <property type="nucleotide sequence ID" value="XM_056938753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL95"/>
    <dbReference type="GeneID" id="81629003"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23187">
        <property type="entry name" value="UBX7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="246"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5469540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="433" mass="46265" checksum="5007464FC4780C21" modified="2023-11-08" version="1">MATFFEGSLQDGIAQAVHDASLSSTWENEYFADGEVAQALRDGSVLLRLTAGSQEAGFLSSFCPVAEFPAVIVIKNGKLEEYLLPGISKEAFRDRITAVLSGRKLSEPTTSLAQEQQQRQAAANTHSSVATPSPIPPAPAAVTQSPPPSSAISSRGSHPPESQSAKTSGTQQAKQPEPKSTKPKPQSAKQAKQEKLPSPTRHTRSTSTTSAHTRKGSVVKAASASASEPKPNPQHSAPRGPPSEYRLQVRLFDGRSIRSSFTPTQTIRNDVRPWLDQQMDGDKRPYNLKHVLTPLPSRTLSTSEESQALRDLGLGSTANLVMIPVASYTEAYASAATSLPARGISAVSNMVYTVASSAMNFAGSFIGYGSGATEANPPASSASPAAVEHTPRSRTTGPNIRTLHDQRNSRDDSQFYNGNQLNFEPRASERKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLA9</accession>
    <name>A0A9W9WLA9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_009159</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469541.1"/>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="250" mass="28786" checksum="17330E3A0103B11B" modified="2023-11-08" version="1" fragment="single">LSLIPDTSHIALIPIIAFGLGTWQVQRLDRKTKMIAKFEDRLIKPPLPLPPRVDPDAISDFDYRRVLATGRYRHDQEMLVGPRMNDGEDGFQVVTPLERGDGQSTILINRGWISRKLMNQKDRPEGLPQGEVTVEGLLREPWKKNMFTPVNKPGEGKFYFPDIQQMAELTGSQPVWIEETMVPELVEIYNRIAKGQPVGRAAEVNLRNNHAQYIFTWYGLSLATSIMLWMVVRKKPNDALRRVRQNRNWS</sequence>
</entry>
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                <person name="Frisvad J.C."/>
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        </location>
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    </evidence>
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    <sequence length="261" mass="27658" checksum="5EE78F4C00DC71AB" modified="2023-11-08" version="1">MSDDSSTSPISVPSSENRPRRGSFASLPFSDLFSKPSTSASSQPPASNAQAIPQRRLSITTLGLSGSPTQTSSAFGSRSFRRGSLSSSWSSVPPNDDVVAEESEPASASGGVTPGSPFSRRLSFGAQALREARAGSIGNGRYPPPTSTAPPVVFFFLLYSGSAAVCIHRRSAGGFRLSAPAELSSHGEGFNWTEALRHRAERAPSLGGSSVSPPQVSRQASHQRAASIATMEQPVREMPKQAKQNKPDFFQEKILRGDFMD</sequence>
</entry>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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            </authorList>
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    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="61" mass="7209" checksum="8D09A2BE9CDB9380" modified="2023-11-08" version="1">MGKEQGVCEINHETYYRNHPADQSHLYRTYENWVKDEEQMIIDEMSGNEENTGCKVSTKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTG8</accession>
    <name>A0A9W9WTG8_9EURO</name>
    <protein>
        <submittedName>
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        <name evidence="3" type="ORF">N7539_008240</name>
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        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
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        <source>
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    </evidence>
    <sequence length="692" mass="77316" checksum="E30C83E62ECF8298" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTI8</accession>
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        </submittedName>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Frisvad J.C."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786962.1">
        <property type="nucleotide sequence ID" value="XM_056937870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTI8"/>
    <dbReference type="GeneID" id="81628120"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="62" mass="7038" checksum="87CFA2C67B4DA2C1" modified="2023-11-08" version="1">MAIVTNERYPRAATQKDDRDEPASRTGSTKPSAKRLPPTNDSTQLYFPPAPLRIPMERDKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTU3</accession>
    <name>A0A9W9WTU3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_007699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787165.1">
        <property type="nucleotide sequence ID" value="XM_056937300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTU3"/>
    <dbReference type="GeneID" id="81627549"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5475412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="245" mass="27903" checksum="D46C57AE9C464E89" modified="2023-11-08" version="1">MSTYESFGQFSAPYSSNDLDLALAECQELEDPLQRLKPFTQMTTESTSLPDLQLYDDCTLGQWLPDTTKQTDLGGFDDFNASINATMPESCTHSLQSTTGINEPIHGNENLSRRKSELLSQSASDNRVVLNRSSSTIRHLNEDYQTWDQHAASLSRRFEKMDGSLNNVQDRLSRLEPRLMGLELSLDKIDGYFQQTEAHLKRALREIDILGDKFKTLDSIMLEVIRREQIAMQEIGELAGRYNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTX3</accession>
    <name>A0A9W9WTX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787210.1">
        <property type="nucleotide sequence ID" value="XM_056937345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTX3"/>
    <dbReference type="GeneID" id="81627594"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052841">
        <property type="entry name" value="PMP_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5475457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="242" mass="26721" checksum="CF4A4BE4BAC48578" modified="2023-11-08" version="1">MAESMNPPLSYEPSATTTHPHEATSLPSEVVACLKNSRFLHLATCDNLTPHISLMSYTYLPSTPYDPYPTIIMTTNTASRKTNHLLSNPRVSLLVHDWVSHRPPTRAPNTQGERDGSPPPAATRSSLASLLLNLNTSALSSISTTITGQARFLEPGSEEERWCKERHLENNTFEEEEINLFGQGQQQHGDAATRRPSMTIEGDVRVVTVPVREGRIADWKGGVRDWILLPSQATQESLVNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU38</accession>
    <name>A0A9W9WU38_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787257.1">
        <property type="nucleotide sequence ID" value="XM_056937392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WU38"/>
    <dbReference type="GeneID" id="81627641"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="465" mass="53203" checksum="A9E73170387EF9EE" modified="2023-11-08" version="1">MAQCLDSCPTEILQSIFDLLSSSEYRALCLVNRNLRTHAEPFLYSQIEWIWREVDGPPPVVKLLRSIIRRPDLASFIKYLCLDGKCFSDGVYRKSIPPLVTPQAKIEIDDLNAFVRNTQLPQADVWIKELQKGTIDAFVALLVAQASNIRHLSLGPAFTQRTEILGVLLRSALCPPSHMKLPTFELLEIVSIRLQTWEDRARGKSIKNTANILPLFYLPNAKSMSVSIESPSVFSWPASYPPSPTNLVNLDLTCVREVSLGNVLAAMVHLRRLSWKWYYDFGLDDDTNKPIVELDQIGAALAHVKDTLEDLSIVADIGVGGNDQFLPAIKTRGCLHEVADLTKLRKIQIPWAFLVGFVQDTNQQLLEVIPRNIEEVIITNDLRLQNDDEMEPSWPAWEWTDHAIITLLENWLRDWKEHTPFLRSVSLHWTDHEFQEWDPQMRRRLKEVGAQVGIFLEIVMIESFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUF6</accession>
    <name>A0A9W9WUF6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787070.1">
        <property type="nucleotide sequence ID" value="XM_056937978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUF6"/>
    <dbReference type="GeneID" id="81628228"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846:SF1">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5475312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="155" mass="18023" checksum="8856490E0EDEA46E" modified="2023-11-08" version="1">MRLSTDYALRNVFFDQYPQFNYNPSTPITNEFARLAKTRKWRLGTRVYRENQRLCVRYEYKFLVGDRTELETLQLVCEKIGLAGDLSSIAKCKKALNQVNINIFDLLDGWKTGEIPLMWPTAKALSVYTVVADKVFPRGQAERDAVLRILIKRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUH5</accession>
    <name>A0A9W9WUH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
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        </citation>
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        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
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        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF17">
        <property type="entry name" value="SEXUAL DEVELOPMENT REGULATOR VELC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="7">
        <location>
            <begin position="67"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5477310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="319" mass="34976" checksum="7D7804EFB824F603" modified="2023-11-08" version="1">MARPFSARASQGGLSNAPNDSSSRPQDESTEPLQPPRKSSYSIPRGFDKLLHHEPESLPSPQPRRPSSQNRYHLHVRQHPVAARACGAGDRDRRPIDPPPIVQILLSDFDSALQEDRDILQDPRFTVGCLLIPVAESTSVPNSAEGSNSQHAGHDIDGLLSADESPSTPLLSGKAFMSPFYVDADPDPNSAPNHPRSTSDTSSRVCPLGEHEFSESHINTSNASKLNQPATFFIFADLSIRSAGLYRLQFRLMNWGSVEDTGQSMPILAEVWSDPFRVYAAKDFPGMRDSSILVEGLKELGFVELKTRGKGKGKGRKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVL0</accession>
    <name>A0A9W9WVL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional regulator Ngg1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_007638</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788038.1">
        <property type="nucleotide sequence ID" value="XM_056937239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVL0"/>
    <dbReference type="GeneID" id="81627488"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="246"/>
        </location>
    </feature>
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        <location>
            <begin position="361"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="572"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5477494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="72503" checksum="6D9F95B146FB15A6" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVN5</accession>
    <name>A0A9W9WVN5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_007651</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterohexamer; composed of 3 copies of TIM9 and 3 copies of TIM10, named soluble 70 kDa complex. Associates directly with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Peripheral membrane protein</topology>
            <orientation evidence="1 15">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788051.1">
        <property type="nucleotide sequence ID" value="XM_056937252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVN5"/>
    <dbReference type="GeneID" id="81627501"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="16">
        <location>
            <begin position="17"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00065568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5477507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="89" mass="9844" checksum="4B8BC465F11250A1" modified="2023-11-08" version="1">MSFLFGGQPKMSSEQKIAAAETEVEMITDMFTRLSESCTKKCIPADYREGDLNKGESVCLDRCVSKFFEVNVKVSEKMQQNAGGGMGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1F0</accession>
    <name>A0A9W9X1F0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788108.1">
        <property type="nucleotide sequence ID" value="XM_056936173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1F0"/>
    <dbReference type="GeneID" id="81626422"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5480678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="611" mass="68416" checksum="E1AEF0DB407E9B7B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X211</accession>
    <name>A0A9W9X211_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="6">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_006684</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788220.1">
        <property type="nucleotide sequence ID" value="XM_056936285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X211"/>
    <dbReference type="GeneID" id="81626534"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="58"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5480790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="532" mass="57500" checksum="53D804AD41FB25B8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X254</accession>
    <name>A0A9W9X254_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein kinase ATG1</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Autophagy-related protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Serine/threonine-protein kinase atg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">N7539_006581</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer. Forms a ternary complex with ATG13 and ATG17.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788117.1">
        <property type="nucleotide sequence ID" value="XM_056936182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X254"/>
    <dbReference type="GeneID" id="81626431"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14009">
        <property type="entry name" value="STKc_ATG1_ULK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000817">
        <property type="entry name" value="Serine/threonine-protein kinase ATG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000399">
        <property type="entry name" value="Serine/threonine-protein kinase atg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048941">
        <property type="entry name" value="ATG1-like_MIT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022708">
        <property type="entry name" value="Atg1-like_tMIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12063">
        <property type="entry name" value="ATG1-like_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21127">
        <property type="entry name" value="ATG1-like_MIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="22"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="342"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="523"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="565"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="883"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="943"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="566"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="886"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="899"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="943"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAJ5480687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="970" mass="106386" checksum="8BBA61C7ECDB3A90" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2A5</accession>
    <name>A0A9W9X2A5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-tryptophan decarboxylase PsiD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_006989</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788525.1">
        <property type="nucleotide sequence ID" value="XM_056936590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2A5"/>
    <dbReference type="GeneID" id="81626839"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022237">
        <property type="entry name" value="PsiD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF9">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G01730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12588">
        <property type="entry name" value="PSDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-tryptophan decarboxylase PsiD-like" evidence="3">
        <location>
            <begin position="43"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5481095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="442" mass="49297" checksum="B59B1483515DF020" modified="2023-11-08" version="1">MSPKEDTHHLHKVGGWMPPNHEDHRKWLGGVIDHVDKNEQKLQPVLQEFQQLIETNTRVYMLITGMFKEIPHKKPYSSDPTGTPQIRDYKHFLQVINHLLTTAPSWIDKAHRVGLVGLPINAVLDWAMGTPSGYAAFLDPEINAMLKKVLNAWGEFLQSPPSAEVLNDTAHGWFGETGHRDLTLVARVGPTAAENLRFQDMFQCDPSAPHFGFKSWDDFFTRKFAEGMRPVAEPDNGKVIANACESKPYRVAHNVHARDTFWIKSQPYSVLDMLHFDDLAEQFVGGTIYQAFLSALSYHRWHAPVSGKVVKAYVVDGTYYSEPLFEGVGNPQSKAATIKMEGQTISQSYITSTATRALIFIEADEPSIGLMAFIGVGMAEVSTCDITVKEGDRLKKGDEIGMFHFGGSTHCLLFRKGVNVSGFPEPGMEENMPVRSHLATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2D7</accession>
    <name>A0A9W9X2D7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788603.1">
        <property type="nucleotide sequence ID" value="XM_056936668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2D7"/>
    <dbReference type="GeneID" id="81626917"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5481173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="134" mass="15754" checksum="241D99E36F6A7753" modified="2023-11-08" version="1">MAFLKNLLRLFSRFAHLKQKSLSRFSSSRREATNASKPKAGHRDGTTTPDRWIREYTAEMQAGKQIEHHQRLVTSRLRSFQDLFDQPGPSNPWFLGDIIECEEELERLHREMAAHRARVIELEAHRPPRCKAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2R0</accession>
    <name>A0A9W9X2R0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_006881</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788417.1">
        <property type="nucleotide sequence ID" value="XM_056936482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2R0"/>
    <dbReference type="GeneID" id="81626731"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001721">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="239"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="529"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5480987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="758" mass="84080" checksum="88A673DC186BFA3B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X302</accession>
    <name>A0A9W9X302_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Suppressor of anucleate metulae protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_006750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788286.1">
        <property type="nucleotide sequence ID" value="XM_056936351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X302"/>
    <dbReference type="GeneID" id="81626600"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4470" evidence="5">
        <location>
            <begin position="60"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5480856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="63917" checksum="82BCD731CE7D40BE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X318</accession>
    <name>A0A9W9X318_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">40S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_006473</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788999.1">
        <property type="nucleotide sequence ID" value="XM_056936075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X318"/>
    <dbReference type="GeneID" id="81626324"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_uS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003140">
        <property type="entry name" value="PRK04053.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5483027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23774" checksum="765B05656C5A3DBC" modified="2023-11-08" version="1" fragment="single">CPHQASPHHRLFHKWLASQLPDPTTAAKVTRHFLLSIPLVDNTSRYARPSPIMSLVSGEKTNFQYILRLLNTNVEGKQKIMYALTQIKGVGRRYSNLVCKKADVDLNKRAGELTTEELERIVTILQTPTQYKIPSWFLNRQRDIVDGKDTQVVSNGLDSKLREDLERLKKIRSHRGLRHYWGLRVRGQHTKTTGRRGRTVGVSKKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X362</accession>
    <name>A0A9W9X362_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788958.1">
        <property type="nucleotide sequence ID" value="XM_056936034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X362"/>
    <dbReference type="GeneID" id="81626283"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5482986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="329" mass="37292" checksum="3D50620838B36512" modified="2023-11-08" version="1">MFEDFSFSTPSSRPGRLSVDVDDRLMVDCDSSLVSPLSSRCPSPQSHRFRNLSHSRPSYYRSQQQQQQQQQQQQQQQQLHNHHQHQHQQPPTSVPFPYESKRLSISTLTQKLHEHTLHTSGAGDLADRGQRPLDGPRLPGRYAGYVLTPPDTDHDSDGRGETSPSLCSNPSPTSIPPEFLTLDRVETPHSIPELPDHLDVRLQRQQISQLQCNEGDIDAVRRTVVEEPFSYHPDLSSDDCHPSSLPPRSSPRRRALTLQRSRFGPADTPTTEARGGRRRSNSCAIQSHRIEKNHHPCHPWRDMSKRGDHHGLRRMSMVSAALASVVERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3F7</accession>
    <name>A0A9W9X3F7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin domain-containing protein DSK2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_006459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788985.1">
        <property type="nucleotide sequence ID" value="XM_056936061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X3F7"/>
    <dbReference type="GeneID" id="81626310"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14324">
        <property type="entry name" value="UBA_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16106">
        <property type="entry name" value="Ubl_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000024">
        <property type="entry name" value="Ubiquitin domain-containing protein DSK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="419"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5483013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="465" mass="48292" checksum="538FC7F70F53D7D4" modified="2023-11-08" version="1">MADNDATTEETPITFTIKSSTDAKFTLSLPLSTLVSKLKEKLASSDYADTPAERQRLIYSGRVMKDSDTLEAYKIKDGHTIHLVKSAASNQQHSATGAPSNPAASGPNNPATTQPAAAAGVPTNLAAGTGNNPLAGLTGARYAGFAQLPGAGLFGPDGGMGPPPDSEAMLSMLENPQIQSQINEALQNPAMIDLMIQQNPMLRDMGPMARELMQRPAFRQMLTDPASIRQMMQMQRAMGMGGGGGLGGGESAFPAPGVTNTTEGTQNNQQQNTPPNPFGQMPNPMMGGNPFAALFGGQGLRQPPTTGENPSETATGNRGDSAQSTTSASGTSDPAAGSAQNPFASLLNPALFGNAGQGGINPFDPQQNPFLRDPALMSQMMQGMGGQGAGEGAAGANPLAALLQGGAGFGTSQPPDNRPPEERYADQLRQLNDMGFFEFERNIEALRRSGGSVQGAVEYLLSNHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6Z1</accession>
    <name>A0A9W9X6Z1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790226.1">
        <property type="nucleotide sequence ID" value="XM_056935032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6Z1"/>
    <dbReference type="GeneID" id="81625281"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000069">
        <property type="entry name" value="HAD-superfamily subfamily IIA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF51">
        <property type="entry name" value="HYPOTHETICAL HAD-SUPERFAMILY HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="484" mass="53427" checksum="7252413DAC12A7E4" modified="2023-11-08" version="1">MTSPGAPNGADTAPQDVAPNEMPAEIPRPSEQGKGLGHSLEVTSSSGQTIEVPATRSSISDTHMQRLSLSPSMKDRRGSRNSFGVSLPIPREPRKSSRLSVVGKPTTHVRNILASELQDQEKEKVKKVKNMCFCFDIDGVLAHGNNAIAEAQACLKMLNGDNELGIQFPYILLTNGGGKTEEARCAQLSEVLGVPISTDQFIQSHTPMQALAEYYENVLVCGGEGFKVREVAEHYGFKNVIHPKDILAWDPTISPCRKFTEEEQKLAKPRDFSKFKFDAIMCFAESHDQSTEFQIILDLLLSANGKLLTRAKNPAARDAVAGHIPIYFSQGDLLCPTEHKGPPRLHLGAFRVALEAQYKALTGRDLERIVYGKPERATYIVADEIIKSWMEEIHGEKRLPENVYMIGDNPQSDIIGGNLYGWNTCLVRTGVFQGQGNDENNPANFGVFDHVYDAVKAAIKKEIGDDFKFKWDPKKHSPHGSAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X717</accession>
    <name>A0A9W9X717_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_005528</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790324.1">
        <property type="nucleotide sequence ID" value="XM_056935130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X717"/>
    <dbReference type="GeneID" id="81625379"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF683">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="43"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5485540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="489" mass="52742" checksum="E95E2641623CDA93" modified="2023-11-08" version="1">MSSSKEKGPLGSESSQENVMVEESRDAVFGEITEDGPNYRAVGWKGTAVLMMKTQIGLGVLSIPIAFDALGVIPGIICLIAIAAITTWSDYIIGVFKLRHREVYNIDDVGELLLGRPGRILFGAAFCLWWIFVAGSGMLGISIGLNAVSSHATCTAVFVAVAAVIAFLFASIQTLGRISWLAWVGLFAILTSSMFPPLAASPGACPFTKAILNPNFLLFLTVMIVTVAVGIQDRPSAAPKDAVWVSDYKLFAHSSFYQAISAISTLVFAFAGTPAFFSIASEMREPEHYNRALIVCQSVVTGFYIAVGVVIYYFCGSYVSSPALGSAGPIVKKVSYGFALPGLIVSTLLFVHIVGKYIFVRLLKGSRHLTANTLTHWITWLACTFSVTLIAYIIASSIPVFGDLVSLVGALLGTPMCFQPMGGMWLYDNWSKGKTHRTTRWKWMVCWSIFVIVAGFFLMVAGTYGSVLSIVNSYRTNGGTSAWTCANNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X874</accession>
    <name>A0A9W9X874_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetylxylan esterase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_005458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790254.1">
        <property type="nucleotide sequence ID" value="XM_056935060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X874"/>
    <dbReference type="GeneID" id="81625309"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF13">
        <property type="entry name" value="ACETYLXYLAN ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040825939" evidence="3">
        <location>
            <begin position="23"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5485470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="234" mass="24113" checksum="BF2E9D6F43D24492" modified="2023-11-08" version="1">MHTKLLAASLFGLGAIAVPLEANVEKRSCPPIHIFGARETSVSPGFGSAGTVVNSILNAYPGSTAEAINYPACGGQASCGYVGYSSSVQQGINAVTSAVNQFNSQCPSTKIVLVGYSQGSEIFDVNLCGGGDPNQGFNNKNVLLSSSAVNMVKAAIFMGDPLFKAGLPYEVGSCRAGGFDARPSGFYCPSASKIQSYCDASDPYCCNGNNPATHQGYGNEYGSQALAFVKSKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCI2</accession>
    <name>A0A9W9XCI2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790814.1">
        <property type="nucleotide sequence ID" value="XM_056933273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCI2"/>
    <dbReference type="GeneID" id="81623522"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="158" mass="17493" checksum="2B35067062D63530" modified="2023-11-08" version="1">MDCFKQILRTFKAPFARKQGKIVEIGPPTNFRKEELPACFSDAESVLTRNLTPSERPHLTSQSQYFDVSDKPQPIGGEGESVQRDEEPSAIGVSQDPQPRPQTERAKFARVRTCLKGFRMSFGSKRVPNGHPEATNGGNDTLSGTITEKAKSDKPSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDJ3</accession>
    <name>A0A9W9XDJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_004256</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791399.1">
        <property type="nucleotide sequence ID" value="XM_056933858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDJ3"/>
    <dbReference type="GeneID" id="81624107"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="21"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="305"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="30"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5489366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="393" mass="43371" checksum="231D8EF4F364A64D" modified="2023-11-08" version="1">MPPKKAQVQEKVLLGRPGNNLKSGIVGLANVGKSTLFQSITKSSLGNPANFPYATIDPEEARVIVPDERFDWLCDHYKPKSQVPANLTVYDIAGLTRGASTGAGLGNSFLSHIRAVDAIFQVVRCFDDAEIIHVEGDVDPVRDLTIISEELRIKDIEFVEKALEALSKQTRRGGQSLEMKKLKEEEATTAKVLQWLQDGKDIREGEWGPKEVEVINPLFLLTAKPVVYLVNLSEKDFIRKKNKYLPKLFEWVKEKSPNSPILPISAQFEERLTQLGDEAAAEECKKLGTASGLPKVITTMRQALNLASFFTTGADEVRQWTIRKGIKAPSAAGVIHTDFEKTFIQAIVYNYSVLRELGDEAAVKAAGKIMTKGKDYVVEDGDIMLIKAGAAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE59</accession>
    <name>A0A9W9XE59_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791714.1">
        <property type="nucleotide sequence ID" value="XM_056934173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XE59"/>
    <dbReference type="GeneID" id="81624422"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF26">
        <property type="entry name" value="FMN REDUCTASE LOT6, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040810971" description="Amine oxidase domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="50719" checksum="DC28AC0E93933674" modified="2023-11-08" version="1">MILSGARRTLAICGLLSLAAFAHGEDNSLTRDVAIIGGGAAGTYAAIRLRDQGKSVILIEKEDRLGGHTNTYEDPVTKTHVDYGVVVFHDNQLVKNYFDRLNVSWLVTDPHFTSGSPVYLDDQSAKPVNYTSPDARAALQTYAAHLAQYPKVESGFFLPDPVPEDLLLPFGEFLAKYPDVGNAAFTIFTFGQGLGDFLSQPTLYVFKNFGLEIIQDIGTGFLVTASQNNQEIYQHATKILGHDVWTSSHVASTPHRRKEGIQLEVKTPSGRRTVKAKKLLIAFPQKLDKLKPFDLDELESSLFGKFMNTGYYTSLVKNTGLPGNFSSTSVGANTPYQIPKLPGVYAVSATAIPGVFDVKYGSPTGLSDDFVRGEILSYIKKLQANGFAEKVPGEPEFVAYHSHTPFELTVARDEIAGGFYKKLYALQGHRNTWYTGAAFDTQDSSMLWNFTEEYILPDLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEZ4</accession>
    <name>A0A9W9XEZ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear segregation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792066.1">
        <property type="nucleotide sequence ID" value="XM_056932107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEZ4"/>
    <dbReference type="GeneID" id="81622356"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="160"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5490937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="55736" checksum="4DE79CE6610BCDBB" modified="2023-11-08" version="1">MATTAPTEARVKPTKPDEEAYKASLAQAEKEHTAAQEKLNAIKAKLDTAKPNNQDSPVVKKQQALRAELSSIRQKQSGFKSSRSSTLEKMNALEATLKARIAEQNNARGKMQFKNVEEIDREVARLEKQVDSGTLRLVDERKALSDISNLRKQRKSFAGLEESQKGIDDLKAQIAELKKTLDNPEAKALSDKYAEIQKELDAIKAEQDSVYKNLNALRDERTKLRNEQQQKYTAIRDIKDNYFKARRAYKEYEDEAWRIRRERQKTEREAFEREKRKKVADKKLEEASQLAYTDEILTAQGLIRHFDPSYDFAALGLDDKKDEGSKFRANVGRTVDDSGLKGMKVVRKDQEEDYFVGTAGKKGKKGGKKGGVAAGAEAGKFNMNVGIIEDFAKVKIDPPMNQSDVPAVVEKLAAKITEWKKNQASKTEENIKKAKEEIARLEQEEAAAAETNGRSTDAAKKPAEANILPTAEAELSQEQDGAADAAEELKKASLEDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF25</accession>
    <name>A0A9W9XF25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_002661</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792223.1">
        <property type="nucleotide sequence ID" value="XM_056932264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF25"/>
    <dbReference type="GeneID" id="81622513"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="167"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5491094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="33912" checksum="EFFF6F4515A1B940" modified="2023-11-08" version="1">MPSSTQSAAAPLTTVFSPPASCTNVQQVSSECQKDCKNLYNIVQITDSNCFPSQWATTATWFSPGIYCPKGYTVADSHTVTSGLQLTETQARCCPSGYTMATDLAQAWWTAEPCTKVSAVTTTLNFTVYSATGASPTTTSEMVIRGPIIHAYPVELRWQSSDSAALGSGSTTASAVPTFTDATTTKTSASTTGPTSSATSPSTAPPSSDGAHGSSGLSTGAKAGIGIGVAAAVIIILALLFCLWRRRKGSASSASPSKERKVSLGNAQDDVYGEIPVRQVPGHKPVELPTRATGWSEELHGQSHPAPSELEAGQAGYDSPMTAKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFA3</accession>
    <name>A0A9W9XFA3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-channel protein CCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">N7539_002777</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Voltage-gated, high-affinity calcium channel that functions together with MID1 to mediate calcium entry into cells. Required during conditions of environmental stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16 19">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792339.1">
        <property type="nucleotide sequence ID" value="XM_056932380.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81622629"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000093">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000118">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000063">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000079">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000098">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 19" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5 19" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9 19" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="687"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="753"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="778"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="814"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="837"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="870"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="943"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1175"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1212"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1303"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1424"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1504"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1536"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1568"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1621"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1721"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="1759"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="112"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1976"/>
            <end position="2125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="1977"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="2004"/>
            <end position="2025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="2044"/>
            <end position="2058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="2062"/>
            <end position="2086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="2087"/>
            <end position="2102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1395"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00067459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAJ5491210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="2125" mass="240423" checksum="282BA74696ADF75A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFC9</accession>
    <name>A0A9W9XFC9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">sarcosine oxidasee (formaldehyde-forming)</fullName>
            <ecNumber evidence="3">1.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_002653</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>sarcosine + O2 + H2O = formaldehyde + glycine + H2O2</text>
            <dbReference type="Rhea" id="RHEA:13313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57433"/>
            <dbReference type="EC" id="1.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.3.1" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792215.1">
        <property type="nucleotide sequence ID" value="XM_056932256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFC9"/>
    <dbReference type="GeneID" id="81622505"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000189">
        <property type="entry name" value="Monomeric sarcosine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008425">
        <property type="entry name" value="PRK11259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF7">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5491086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="386" mass="42517" checksum="D9591DF48A6D5D35" modified="2023-11-08" version="1">MAHYDVAVVGLGVLGSGAAYYAAQKGAKVIAFEQFELGHVRGASHDTSRIVRTSNFSPELVALAKSAYQDWAELEKASGQKLLTITGGLVFFPDEPGTPALARDFTTSLDQNGVPHELLDSRQVRERWPQFELPEAVSTVYTADSGIAHASRTVGALQALARAHGAILREQTRVVRIVPRSANDRRTVIIHTSKGQFQAYKVILATDAWTDRLLSPLGTHIPVTIMQEQVTYFKPTDASKFEPDRFPVWIWNGATCFYGFPCYGEPTIKAARDTSNNFMTPEQRTYVHSPQLLGELSAFMNNLIPDESRQPLRTVTCQYTITPERRFVISPLELHPEIIVGLGAAHAFKFAPAFGRVLAELAVDGFTKEDISQFGIPVSAGDRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFF3</accession>
    <name>A0A9W9XFF3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription initiation factor IIA large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_002837</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792399.1">
        <property type="nucleotide sequence ID" value="XM_056932440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFF3"/>
    <dbReference type="GeneID" id="81622689"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000006">
        <property type="entry name" value="Transcription factor TFIIA complex subunit Toa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.100:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01371">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="87"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00074154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5491270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="418" mass="45637" checksum="3A9D692AD20822AF" modified="2023-11-08" version="1">MSNQQVGAVFEKVIKDVCENSQVDFEESGVDQKTLLDLRETWQKKLSSVNVAHFPWDPPVQPVAQAPLPPQATVPSNAPRPPPPSQPQHQPQPQHHQPQQQQQQQQQQQQQQQQQQQPQQPQHQQHVPPPVSMAQQTPIPSPAPAAPVAPVATAQMNAPRVKTEPGASGMSSIPPMHPNMSASTTPNPQMARDRAAAQLTQRFGASAATSVSQLQSQSAGQQQYTPQHYPSNGNAPQIKQESNHSSLGSGQTDGAGDALSDWKAEVARRREAAQNGQGDHLLREYIKHQMSGLEGGGLLRPLVVGYKGSSLRSGRSSASRKRIAIGVFPPKAPAQFDGADDDLKEEDDEDAINSDLDDPDDLVDHEAEADEAEGQVMLCTYDKVQRVKNKWKCTLKDGILTTGGKEYVFHKGQGEFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFG0</accession>
    <name>A0A9W9XFG0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002838</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792400.1">
        <property type="nucleotide sequence ID" value="XM_056932441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFG0"/>
    <dbReference type="GeneID" id="81622690"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000676">
        <property type="entry name" value="C2H2 transcription factor (Sfp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="442"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5491271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="568" mass="60549" checksum="8ECDEC9928A86C60" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFG1</accession>
    <name>A0A9W9XFG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792260.1">
        <property type="nucleotide sequence ID" value="XM_056932301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFG1"/>
    <dbReference type="GeneID" id="81622550"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="117" mass="13209" checksum="B588B70E9284A28C" modified="2023-11-08" version="1">MFYSLMKHQLTRPSAFSLTKVASASLTGKVPPNVRTSEEFFVTATWPDDDSSFKSDVFDGQARTITSQTSPMQFSAAEIERHKADIYDSIFPKDPSRFLKRQTSNNLPDQEPSLDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFP0</accession>
    <name>A0A9W9XFP0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_002848</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792410.1">
        <property type="nucleotide sequence ID" value="XM_056932451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFP0"/>
    <dbReference type="GeneID" id="81622700"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5491281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26763" checksum="AAFE6914746D4342" modified="2023-11-08" version="1" fragment="single">CLAALIDLGHLRDVRASSTFQISVLEQEMRTQIFWVIYTFERALGTMMGRAIGVQDELASGNVGGRSVNSPPSHMTYSIHLFRLARLNSEIKYIMHSVCREAPRYAYPPVPDIQVWQIDMVDRLKKWHITIPRSDEIQSITRLCECKYHEMMVLLLRASPAIPEPSETSLTQCFRHATSLVRGLGALYIQDSLLYSRFVAHSTFLSILLILHFLWKISRLASQVQISDVIADTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFW8</accession>
    <name>A0A9W9XFW8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase F(0) complex subunit e, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_003063</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase e subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792625.1">
        <property type="nucleotide sequence ID" value="XM_056932666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFW8"/>
    <dbReference type="GeneID" id="81622915"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008386">
        <property type="entry name" value="ATP_synth_F0_esu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05680">
        <property type="entry name" value="ATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 11" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5491496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="96" mass="10944" checksum="8E17D732896DBEBC" modified="2023-11-08" version="1">MASTQGVNVFRYSALVAGLIYGVYHQSSITQAAKRTEIEHEYARKERLIEQAKAEYKKKTQPKQETTTQSSGVITNFEDPKFDLEAFLLAKFKENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFZ2</accession>
    <name>A0A9W9XFZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002464</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792026.1">
        <property type="nucleotide sequence ID" value="XM_056932067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFZ2"/>
    <dbReference type="GeneID" id="81622316"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000113">
        <property type="entry name" value="Cytochrome P450 monooxygenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF85">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5490897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="515" mass="59008" checksum="0D9F5371D8EBB5EA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG38</accession>
    <name>A0A9W9XG38_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UPF0357 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_003156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0357 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792717.1">
        <property type="nucleotide sequence ID" value="XM_056932758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG38"/>
    <dbReference type="GeneID" id="81623007"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018559">
        <property type="entry name" value="DUF2015"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023:SF1">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09435">
        <property type="entry name" value="DUF2015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5491589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="124" mass="14191" checksum="DBAD2474E6EA3850" modified="2023-11-08" version="1">MGYLFYYSLVLSVIVAGTALYLTRARWFHLLPVPDYIYDRLPSSFTADLEAGMSSSQFDLAANVAEGDTRAGLDQTAKREIKRIMRVRRVTFDEARRIYTEQRFANNNIGPDGRPRDPKFVSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH77</accession>
    <name>A0A9W9XH77_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_001678</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793312.1">
        <property type="nucleotide sequence ID" value="XM_056931281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH77"/>
    <dbReference type="GeneID" id="81621530"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000060">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5492932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="155" mass="17529" checksum="C1711B0CE69244AA" modified="2023-11-08" version="1">MASQKRIGKELSELTASPPEGISVELADEADLFKWKVFMNGPEGSPYEGGKFLVNLTLPNEYPFKPPTVSFGTKIYHPNVTNDEKGSMCLGMLRADEWKPSSKIAAVLEFARQLLLEPMPDDAVEGRIAEQYKSDRKRYDEIAREWTRKWAMSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH78</accession>
    <name>A0A9W9XH78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_001697</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793331.1">
        <property type="nucleotide sequence ID" value="XM_056931300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH78"/>
    <dbReference type="GeneID" id="81621549"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="599"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="607"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5492951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="652" mass="72792" checksum="B3D848B97F38E06C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHK1</accession>
    <name>A0A9W9XHK1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Cyanide hydratase</fullName>
            <shortName evidence="7">CHT</shortName>
            <ecNumber evidence="2 7">4.2.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cyanide-degrading nitrilase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Formamide hydrolyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_001411</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydration of cyanide to formamide. Degradation of cyanide may be important for plant pathogenic fungi in infection of cyanogenic plants.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>formamide = hydrogen cyanide + H2O</text>
            <dbReference type="Rhea" id="RHEA:21720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16397"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="EC" id="4.2.1.66"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Oligomer of dimers, forming left-handed helical fibers.</text>
    </comment>
    <comment type="induction">
        <text evidence="7">By cyanide.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.66" evidence="2 7"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793045.1">
        <property type="nucleotide sequence ID" value="XM_056931014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHK1"/>
    <dbReference type="GeneID" id="81621263"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030196">
        <property type="term" value="F:cyanide hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019500">
        <property type="term" value="P:cyanide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000011">
        <property type="entry name" value="Cyanide hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03224">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037544">
        <property type="entry name" value="CN_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF4">
        <property type="entry name" value="CYANIDE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5492665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="363" mass="40844" checksum="14F0BD42C0E8631B" modified="2023-11-08" version="1">MGPVLKKYKAVAVNAEPGWFNLEESVRRTVHWIDEAGKAGCKFIAFPELSDQREGIPGYPYWMWKVNYQESLPLLKKYRENSLPSDSDEMRRIREAARKNKIFVSLGYSEVDLASLYTTQVMINPAGEIINHRRKIRATHVERLVFGDGTGDTTESVMDTEIGRIGHLNCWENMNPFLKAYAASLGEQVHVAAWPLYPGKETLKYLDPYTNVAEANADLVTPAYAIETGTFTLAPWQTITTEGIKLNTPPGKDLEDPHIYNGHGRIFGPDGQNLVPHPDKDFQGLLFVDIDLDEIHLTKSLADFGGHYMRPDLIRLLVDTNRKDLIVHEDRVNGGLVYRKTVDRVGLSIPLDSPPAVAELTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHT8</accession>
    <name>A0A9W9XHT8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14 17">Homoserine dehydrogenase</fullName>
            <shortName evidence="14">HDH</shortName>
            <ecNumber evidence="5 14 17">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">N7539_001900</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine; production of homoserine leads to a branch-point in the pathway as it can either be O-phosphorylated for processing to threonine, or O-acylated for processing to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-homoserine + NADP(+) = L-aspartate 4-semialdehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:15763"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14 18">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 14 17"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793534.1">
        <property type="nucleotide sequence ID" value="XM_056931503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHT8"/>
    <dbReference type="GeneID" id="81621752"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000006">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_Aspkin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070:SF5">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 14 17" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="10 14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14 17" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/homoserine dehydrogenase NAD-binding" evidence="21">
        <location>
            <begin position="12"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="20">
        <location>
            <begin position="157"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>L-homoserine</name>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR036497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ5493154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="372" mass="38830" checksum="730206E67D1F261F" modified="2023-11-08" version="1">MSASPIYLGVIGVGGVGTAFLSQLARLPNAPKLVLLARSSQTLLAPTPAYSPAIPAADWATASAGAGASLTKAGALPADEIAAYLASAPGRAILVDNTSDINLARQYPTFLKKGISIVTPNKKGFSDDLTLWKDIFASASEGKALVYHESTVGAGLPVLSTLKDLVATGDEVTRIEGVFSGTLSFLFNTFAPASGSSDAKWSDVVAQAKELGYTEPDPRDDLNGMDVARKLTILARLAGLEVSRPDSFPIESLIPSELATLPSSADGIAEFMKRLPEFDSQMTSIKENAEKEGKVVRYVGSIDVASKDVKVGLQSFSKDSAIAGLKGSDNIISFYTKRYGSNPLIVQGAGAGGEVTAMGVSSDLIKVVQRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHY6</accession>
    <name>A0A9W9XHY6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Acetolactate synthase</fullName>
            <ecNumber evidence="4 12">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_001944</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 12"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793578.1">
        <property type="nucleotide sequence ID" value="XM_056931547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHY6"/>
    <dbReference type="GeneID" id="81621796"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000053">
        <property type="entry name" value="Acetolactate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="16">
        <location>
            <begin position="92"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="14">
        <location>
            <begin position="292"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="15">
        <location>
            <begin position="499"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="31"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5493198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="695" mass="75939" checksum="BCA2785110F15EBC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHY9</accession>
    <name>A0A9W9XHY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein TOXD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_002087</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793721.1">
        <property type="nucleotide sequence ID" value="XM_056931690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHY9"/>
    <dbReference type="GeneID" id="81621939"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="16"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5493341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="348" mass="37424" checksum="0941CF669EFDDE58" modified="2023-11-08" version="1">MSTQKAVIVVEPKKEGLVTDRPIPALRDDYVLVKNVSVGLNPTDWKHVAFLSPPGVLVGCDFAGVVEEVGKDVKKPWKKGDRICGFAHGGNAVQPEDGAFAEYIVAKGDVQIKVPDNLTFQEAATLGVGTLTVGQALYQSLKLALPTEPIKDQTPILIYGGSSATGTLAIQYAKLSGYKVITTCSPHNFDLVRSLGADSVYDYKDSESPAKIREETNNKLKLVLDCISLEPSAKFCEQAISTEGGEYSALLSVKVPRDNVNSRSTLGYTAMGEAFKFGNMDIPAKPEDLAHAKMFVPIAETLLAEGKVKVHPPKVGKDGLKGVIEGMKLMKEDKVSGEKLVYNVSETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI32</accession>
    <name>A0A9W9XI32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_001766</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for 60S ribosomal subunit synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793400.1">
        <property type="nucleotide sequence ID" value="XM_056931369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XI32"/>
    <dbReference type="GeneID" id="81621618"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000002">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="299"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="448"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="483"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5493020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="511" mass="56762" checksum="E0B91F2E97A9F9CB" modified="2023-11-08" version="1">MADYLLFESPMGYSLFKVSLQGDAVGNRLKEVQAGVNDLAKFGKMIDLASFLPFENNKQALGEINDVSEGVASETLVSFLDLNLPKPSKKKKVVLGLLDKGLAGSIKSAFSFVDCETGDTSEVVQDLLRGIRLHFPKLLSQLREGDMDTAQLGLGHAYSRAKVKFSVQRDDNHIIQAIAILDQLDKAINTFSMRVREWYSWHFPELFKIVSDNQRYAQVALFVQDKKSLTDESLHDLAALVEDDKDVAQSIIDAAKRSMGQDISESDMENVIAFAERVVSISKYRKSLYQYLVSKMSVVAPNLAALIGEIVGARLISHAGSLTNLSKYPASTVQILGAEKALFRALKTKGNTPKYGLLYHSSFIGRAGPKNKGRISRFLANKCSIASRIDNFSESPTTKFGEVLKQQVEERLEFYSTGAAPTKNEVAMRSAMDAVLAGIDVDVDDSDAEMEDADVKKEKKEKKEKKEKKEKKEKSDKKKKRKSDVGEGESEKKKKRKHDADTEPSKKKQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI49</accession>
    <name>A0A9W9XI49_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome biogenesis protein SLX9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_002172</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLX9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793806.1">
        <property type="nucleotide sequence ID" value="XM_056931775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XI49"/>
    <dbReference type="GeneID" id="81622024"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028160">
        <property type="entry name" value="Slx9-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15341">
        <property type="entry name" value="SLX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5493426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="156" mass="17479" checksum="CB1C7B48A1B97771" modified="2023-11-08" version="1">MKAKTTRSAPVKASAFGNDFRTSKKDKRQIKHATLMSKIAKNSKTPKKRRPSKKLVANLESLADALPEAGQDNATSQVNVIKQTTIRHKPGAMKRREKLEKVERDRFAKNMAQLATIQPSSTEVAPESASTTNRWSALRNFISQTMEQQPVFKSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI75</accession>
    <name>A0A9W9XI75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_001741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793375.1">
        <property type="nucleotide sequence ID" value="XM_056931344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XI75"/>
    <dbReference type="GeneID" id="81621593"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5492995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="188" mass="22048" checksum="EB0A6587DCA39A79" modified="2023-11-08" version="1">MRSTLTESPGQGNRVWRESVSVCLCGANFPVSVLSCHEGLRPCRCSSRQWQTGTHQETRFRVLRAPFTLSTCTVSSGFESQSTESQASALQFSNQLQRPAARVHESRPHLGKGSLQAASRQHYYYYYYYYYYYYYYYYYYYYYTATTTVLLLQYYYYSTTTTVIQFVVRTTRLGRFCHASWASEPNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XL76</accession>
    <name>A0A9W9XL76_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_000145</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794042.1">
        <property type="nucleotide sequence ID" value="XM_056929749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XL76"/>
    <dbReference type="GeneID" id="81619998"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905202">
        <property type="term" value="C:methylcrotonoyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000004">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000007">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF13">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="7">
        <location>
            <begin position="73"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="8">
        <location>
            <begin position="337"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5495029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="577" mass="61550" checksum="5FF2E9C8830A67EA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLF1</accession>
    <name>A0A9W9XLF1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="3 10">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">NAD(P)HX epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_000269</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3 10"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794166.1">
        <property type="nucleotide sequence ID" value="XM_056929873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLF1"/>
    <dbReference type="GeneID" id="81620122"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000005">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="63"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="129"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5495153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="249" mass="27124" checksum="1BF9CBF8FF1F1E9C" modified="2023-11-08" version="1">MTIQALSAKDAASLDKDLMDVNVGGWSLDQLMELAGLSVSQAVWRMHPLSQGKRVLVVCGPGNNGGDGLVAARHLKHYGYEPTIYYPKEGKNELYQRLKTQLQNLSVPFTDDLTSGLSQSDLLIDAIFGFSFGGPLRDPFGSIISQIENAKIPVLSVDAPSSWDINSGPPSSGPGAKFMPQALISLTAPKPCVKYYQGRHFIGGRFLTTSIAEKYGLVCPDYQGIDQVVEVFKDGDGEFRYAPKEESKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLJ5</accession>
    <name>A0A9W9XLJ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794270.1">
        <property type="nucleotide sequence ID" value="XM_056929977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLJ5"/>
    <dbReference type="GeneID" id="81620226"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018811">
        <property type="entry name" value="MRX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002:SF1">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10306">
        <property type="entry name" value="FLILHELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="216" mass="24300" checksum="50E305F5EED732E7" modified="2023-11-08" version="1">MSTQRPLARAHMLRAIRTHTVRSSGRVSRRSLATPAHPPPAPKSVPPHSKDTQSYLRRLNERLPRFLRRYTTPLLGAPVTHVTSFLILHEITAIVPLFGLVAAFHYSAWMPDLRSESESGESSAFDQGVRRFGRWLGKKGWIEESDVKTVAEHEVTGITLREHAGVRLLLEFATAYAMTKALLPLRIAASAWATPWFARSVLTPTTNMARRLFSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLW4</accession>
    <name>A0A9W9XLW4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mmc1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793928.1">
        <property type="nucleotide sequence ID" value="XM_056929635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLW4"/>
    <dbReference type="GeneID" id="81619884"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056196">
        <property type="entry name" value="Mmc1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38644">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38644:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23868">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mmc1_N"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mmc1 C-terminal" evidence="1">
        <location>
            <begin position="389"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5494915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="617" mass="68552" checksum="9E402ABF859EC42E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMB7</accession>
    <name>A0A9W9XMB7_9EURO</name>
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        <submittedName>
            <fullName evidence="6">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_000256</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794153.1">
        <property type="nucleotide sequence ID" value="XM_056929860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMB7"/>
    <dbReference type="GeneID" id="81620109"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF37">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5495140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="277" mass="30883" checksum="11D06FAA7761C166" modified="2023-11-08" version="1">MSDGNVTVASNVLGTIGTVLWCIQLIPQIWYNYRRKKTDGFPAAMMLLWASCSVPMGAYFILQQVNIPLQVQPQLFGFFSLVAWGQILHYNHDYTRRKAITTCFGIVLLFGGLEALLVLTLRIPYKKGVTWPDLVVGIVGAILISAGLIPPYFELWKRDGRVIGFNWVFLSIDTLGGLFSLFALAAQGSFDILGGIMYILVVVLEAGIYISHLIWRFRYRQLRKEAKMSGRSIDELLELGSRESTQSCRLSNSVGLVNQAQTGDVEEQVAASPRQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMM8</accession>
    <name>A0A9W9XMM8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_000476</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794373.1">
        <property type="nucleotide sequence ID" value="XM_056930080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMM8"/>
    <dbReference type="GeneID" id="81620329"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000388">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000451">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="31"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5495360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="575" mass="63332" checksum="41C0F9C2A73B6652" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMY7</accession>
    <name>A0A9W9XMY7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_001060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794957.1">
        <property type="nucleotide sequence ID" value="XM_056930664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMY7"/>
    <dbReference type="GeneID" id="81620913"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="104"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="617"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="745"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5495944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1218" mass="134554" checksum="9F75ECC210241086" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN65</accession>
    <name>A0A9W9XN65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_000450</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794347.1">
        <property type="nucleotide sequence ID" value="XM_056930054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN65"/>
    <dbReference type="GeneID" id="81620303"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058545">
        <property type="entry name" value="Beta-prop_EMC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25293">
        <property type="entry name" value="Beta-prop_EMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040749610" description="ER membrane protein complex subunit 1" evidence="12">
        <location>
            <begin position="19"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="925"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="14">
        <location>
            <begin position="18"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="13">
        <location>
            <begin position="730"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5495334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="957" mass="103240" checksum="C2C9FE8F54ECC0F8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XNA9</accession>
    <name>A0A9W9XNA9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-lysine N-methyltransferase EFM6</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor methyltransferase 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">EFM6</name>
        <name evidence="2" type="ORF">N7539_000736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XNA9"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03198">
        <property type="entry name" value="Methyltr_EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033684">
        <property type="entry name" value="EFM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF152">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="263" mass="28769" checksum="F8F496B23B9F6F5F" modified="2023-11-08" version="1">MTSRSPSPDTVLNAPLLVTDSLAPPRDIKAAGTTSTTFDGLLKEPLLLKEDLKNGCGGQFWPAGMVLSKYMLSTHAKDLAGKSIVELGAGGGLVGLAVARGCEIGLPLHITDQVPMFDLMKDNIALNHLDSAVVASVLDWGEPIPGHIPSKPDVILAADCVYFEPAFPLLITTLQDLLGPNSVCYFCYKRRRRADLRFMKMAKKAFDVQEVRDDPNAAEYSRESLYMYTIRMKPTKQPATTTRDHISTMKESTISLAEVENQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XP99</accession>
    <name>A0A9W9XP99_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_001201</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795098.1">
        <property type="nucleotide sequence ID" value="XM_056930805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XP99"/>
    <dbReference type="GeneID" id="81621054"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="179"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5496085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="364" mass="41271" checksum="466BEB028CAA56C1" modified="2023-11-08" version="1">MASHDSFSDIEQRNRLPTLFEVLSRRTLAPVDLFSFYIYMRDQHRSVDYLDFWLDVSQHMSLCRHYVRELRRSVLVATPDMERIDSRGSAMLENLESLGDIPLVEAGPSRMHQNEKDRDADHRLSAFLRSEGHTSHSPQNSVGSQQSGLDRRPSSGNGNGVDSNSPGHTVGRHDIRASAEKILYTYLLPGAEREIVLPEAMVSTCINLIEDDGRDDPQVFDSAKDYVFQAMERDAFPGFLQAKALGNLVPLSIIARLAFALICFGAGFWAAFYVVLRNEPRHVRCWVILPFAIASYFIVSYRYKIDPVMAFLGYSEYTFMNWGVIREPYVRKLLNKRALITALMSFITAAALSILFIFVPGTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ76</accession>
    <name>A0A9X0BJ76_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alpha-1,3-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_009588</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785678.1">
        <property type="nucleotide sequence ID" value="XM_056939183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJ76"/>
    <dbReference type="GeneID" id="81629433"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="61"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5466632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="65627" checksum="665897017ABD14E1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJF3</accession>
    <name>A0A9X0BJF3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TMEM14-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_009022</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785994.1">
        <property type="nucleotide sequence ID" value="XM_056938617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJF3"/>
    <dbReference type="GeneID" id="81628867"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668:SF53">
        <property type="entry name" value="TMEM14 PROTEIN HOMOLOG YJR085C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5469404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="108" mass="11450" checksum="7ECEF155902183AC" modified="2023-11-08" version="1">MAEHPSFTLAALLPAGGALGYFKTRSAPSLIAGVGLGLSYGYAGYLIKENKDYGTELALGNSVLLLGSAIPRIVKTRARAPMPLILGATGLLAAFYYQKKVREFRFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJI5</accession>
    <name>A0A9X0BJI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_009259</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786231.1">
        <property type="nucleotide sequence ID" value="XM_056938854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJI5"/>
    <dbReference type="GeneID" id="81629104"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF78">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="23"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5469641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="562" mass="62234" checksum="BCC45092BCB21F8D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJJ4</accession>
    <name>A0A9X0BJJ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Efflux pump dotC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_009273</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786245.1">
        <property type="nucleotide sequence ID" value="XM_056938868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJJ4"/>
    <dbReference type="GeneID" id="81629118"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="48"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5469655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="534" mass="57682" checksum="D1871DF337A54476" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BN98</accession>
    <name>A0A9X0BN98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5474972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786730.1">
        <property type="nucleotide sequence ID" value="XM_056937638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BN98"/>
    <dbReference type="GeneID" id="81627888"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5474972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="160" mass="17961" checksum="1EB20FDCABD37419" modified="2023-11-08" version="1">MHSNATYTGTVFSVIHRLHDSYVKANLVWLSIGLIVTLLLVINVAILVSLVNVFNGVMDLEKQPAVEDMEAQGNEDVAASTKELEIDDFLKQGMECHFKTEFPVSFSRGLTICLTVHAAVPDRCAEQPFSWVEITWTLSPEERRDAVIREARGWSRSLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNB6</accession>
    <name>A0A9X0BNB6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_007827</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787293.1">
        <property type="nucleotide sequence ID" value="XM_056937428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNB6"/>
    <dbReference type="GeneID" id="81627677"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17998">
        <property type="entry name" value="DEXHc_SMARCAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000014">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="598"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="952"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="67"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="322"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5475540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1136" mass="125663" checksum="F054740974FC1C88" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNB8</accession>
    <name>A0A9X0BNB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786790.1">
        <property type="nucleotide sequence ID" value="XM_056937698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNB8"/>
    <dbReference type="GeneID" id="81627948"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5475032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="115" mass="12987" checksum="34A1A5824C76324B" modified="2023-11-08" version="1" fragment="single">VESSGFHLQTLAARGLFTNSTHNRQFPRSSVRTRIKVNSQLVARSLSSDLRPAEDIVSRLDQDQKLCRDEKPPNSLVLKLSKEPPELSAAISWHLTPRNGLSEKKFTRPKLSLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNV6</accession>
    <name>A0A9X0BNV6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small ribosomal subunit protein uS4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_007463</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787863.1">
        <property type="nucleotide sequence ID" value="XM_056937064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNV6"/>
    <dbReference type="GeneID" id="81627313"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000025">
        <property type="entry name" value="30S ribosomal subunit S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="12">
        <location>
            <begin position="122"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="183"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="294"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5477319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="436" mass="49065" checksum="DB809929AFBF1C38" modified="2023-11-08" version="1">MRNTASTSLSKGKIRQSWSKYNLYNLQRFRKPTTASRTFFQQKWTAKAAARAYHGEQVREGQWKRMFSKHIRSVIPMNTTDLAADDGSKESAGRGSGLSETSSKNRSRPIPFTQMAFAPLERRLDVAIFRALFASSTRQARQFVIHGAVTVNGQKMRHPSYLLNPGDLFQVDPERVMYATGAPKTAFERREARQMKQKSAEPEAETEAEAEQTEAKPETTEKESAKDTLRALMSQAKTIMSTDKDVLPAKRKQELRGFQKAVRRVLSRSDTSSVLTDNLEAQFSQLTLLLNAKRAEKKPAKGSERETQDKKTSPTSTKSGEAASNALSDAFQAAAEGGEVDTSELTDEEFDVLRHALTQMRDNPIDHSKPYATPWRPRDYMAPFAFIPRYLEVNQNICAAVYLRHPVARPGSAEVPTPFGESISTPAYGWYLKKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BP88</accession>
    <name>A0A9X0BP88_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787760.1">
        <property type="nucleotide sequence ID" value="XM_056936961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BP88"/>
    <dbReference type="GeneID" id="81627210"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5477216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="50219" checksum="892E9DE114300FBF" modified="2023-11-08" version="1">MSRNKHFSPDREPLSHHQHHRSMSDPTLQPHHVSGPFALLNPTSAYYTPNTKVDHPSLHSHEASQAKTNQEKQEDAHSPTNTPPPTQAVEHIWRSRDNRKGRHAIRIDYNAPPTDTALIAPHPTTTAKAIAQGILRMFTRAPVWDVSWLVAFTFVVGSIIWIVNAFFVWLPLVDPSTEFSGEVSSGGRDHGIHRCDGTGCFGWALEKELGKVHGDGDASRPVTRLEPRIEECTHHHINRRNLVGQGLKRTASDPHHHHHHHHHDSLDFSNGYTTTSSSGSKSFRWLPSWDELKSHYIHELGFLASLIQFLAATIFWIAGFTGLPGINNHLSQPVANGVYWVPQIVGGAGFIASGLLFTLETQEKWYKPAFHVLGWHVGAWNFVGGIGFTLCGALGPASSSHSGVEYQTTLATFWGSWAFMVGSTLQWYESLQKYPVERKRGTRGSATDSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSS8</accession>
    <name>A0A9X0BSS8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_006966</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788502.1">
        <property type="nucleotide sequence ID" value="XM_056936567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSS8"/>
    <dbReference type="GeneID" id="81626816"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01401">
        <property type="entry name" value="PncB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006406">
        <property type="entry name" value="Nic_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="9">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="8">
        <location>
            <begin position="182"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="8">
        <location>
            <begin position="312"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5481072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="468" mass="53218" checksum="DA0EEA2863D748F4" modified="2023-11-08" version="1">MGHNATPPLPEGIFSLLDTDLYKLTMQCAILKYFPDVHVTYAFTNRTPHMKLRRAAYKWLLEQMEKLANIRVTPEERAWLKQKCPYLNDTYLTFLDTFKLNPEEQIEIKFTPTQDTGSEEDEGDIEYTIKGLWVDTILYEIPLLALTSQAYFMFSDKDWDYNNQEEKAFRKGCELLENGCVFSEFGSRRRRDYHTQDLVMTGLCRAAEEGKRRGWKGVFTGSSNVHFAMKYNVNAVGTVAHEWYMTIAAITDDYENANELGLRYWLGCFGEGVLGVALTDTFGTPAFLDAFRRPILEPTVDSDASAKPPVTSDVHTDKSHSKKTYARVYAGVRQDSGDPSYFVKMVRDFYDREGITEKKTVVFSDSLNIEHCLEYKAIAEEAGFSPTFGVGTFFTNDFTNKSNGEKSKPLNIVIKIATANGRPAVKLSDNMGKNTGDRAKVQEVKKKLGYTEQSWAEGDESNRWDGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSW1</accession>
    <name>A0A9X0BSW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_006378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788904.1">
        <property type="nucleotide sequence ID" value="XM_056935980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSW1"/>
    <dbReference type="GeneID" id="81626229"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001">
        <property type="entry name" value="OS01G0253100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001:SF931">
        <property type="entry name" value="OS11G0664100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5482932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="258" mass="28801" checksum="6059A42A31305200" modified="2023-11-08" version="1">MSSPFLDIRGDPIPKEQVVGCGSSAVILLQNGVAVKTPLRYLWSSDSDVEVNVQSVRREQDVYRRLQSLKDDRSKGIVSCIGFSAEATQLAYMANGDLRTYLAKCRPSHQLQLAWFHEMARTLCYIHDRRVLVADIATRNFLLDTDLSLKICDFSEASLLPLDCNMETVDDNGFTAQIDIGLLGTVMYEVVTGSKCDVDLFKDNSPTDGRAYWPERKSLPSTQGIWLGWIIEGCWDGGFRSAHSLLRALDSVRTGEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BT32</accession>
    <name>A0A9X0BT32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788802.1">
        <property type="nucleotide sequence ID" value="XM_056935878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BT32"/>
    <dbReference type="GeneID" id="81626127"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21210">
        <property type="entry name" value="CH_SCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="21"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5482830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="647" mass="72801" checksum="535B291630947DF4" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BU98</accession>
    <name>A0A9X0BU98_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">N7539_005750</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789224.1">
        <property type="nucleotide sequence ID" value="XM_056935352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BU98"/>
    <dbReference type="GeneID" id="81625601"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007128">
        <property type="entry name" value="PMF1/Nnf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459:SF2">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="18">
        <location>
            <begin position="30"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="279"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="340"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="454"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="521"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="382"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="563"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="608"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="680"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="710"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="731"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="757"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ5483954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="772" mass="85816" checksum="ED1118C8E132114F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUM0</accession>
    <name>A0A9X0BUM0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prolyl endopeptidase</fullName>
            <ecNumber evidence="5">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_005030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser. Also, involved in the degradation of oxidized and glycated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S9A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789826.1">
        <property type="nucleotide sequence ID" value="XM_056934632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUM0"/>
    <dbReference type="GeneID" id="81624881"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF5">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="6">
        <location>
            <begin position="449"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00045885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5485042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="660" mass="72822" checksum="5EA73DEE1842FD6C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUP6</accession>
    <name>A0A9X0BUP6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Malate synthase</fullName>
            <ecNumber evidence="3 10">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_004848</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the malate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="3 10"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789644.1">
        <property type="nucleotide sequence ID" value="XM_056934450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUP6"/>
    <dbReference type="GeneID" id="81624699"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1220.12:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.360:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="entry name" value="Malate synthase, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048355">
        <property type="entry name" value="MS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048356">
        <property type="entry name" value="MS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF1">
        <property type="entry name" value="MALATE SYNTHASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20659">
        <property type="entry name" value="MS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20656">
        <property type="entry name" value="MS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Malate synthase N-terminal" evidence="12">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase TIM barrel" evidence="11">
        <location>
            <begin position="165"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase C-terminal" evidence="13">
        <location>
            <begin position="415"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5484860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="540" mass="60963" checksum="4103B2279AD63633" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUR8</accession>
    <name>A0A9X0BUR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_004893</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SEC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789689.1">
        <property type="nucleotide sequence ID" value="XM_056934495.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81624744"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1030:FF:000008">
        <property type="entry name" value="Protein transport protein sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024468">
        <property type="entry name" value="Sec16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12935">
        <property type="entry name" value="Sec16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 N-terminal" evidence="14">
        <location>
            <begin position="241"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 central conserved" evidence="13">
        <location>
            <begin position="940"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="12">
        <location>
            <begin position="1117"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="289"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="451"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="509"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="596"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="746"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="831"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1466"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1754"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="632"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="663"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="756"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="798"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="847"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="890"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1540"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1653"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1684"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1776"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1795"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1847"/>
            <end position="1860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5484905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1895" mass="202082" checksum="8C5A230F4F2BA269" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUS1</accession>
    <name>A0A9X0BUS1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">N7539_005491</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphorelay sensor kinase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:osmosensory signaling via phosphorelay pathway"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HisKA"/>
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    </dbReference>
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        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ethylene receptor 1"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="His_kinase_dom"/>
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        <property type="entry name" value="HisK_dim/P_dom"/>
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        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
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        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
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    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
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    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0902">Two-component regulatory system</keyword>
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        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="20">
        <location>
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    </feature>
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        <location>
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        </location>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1090" mass="119557" checksum="8970FFC93F2C484E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BVB8</accession>
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        <source>
            <dbReference type="EMBL" id="KAJ5485490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXG6</accession>
    <name>A0A9X0BXG6_9EURO</name>
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        <recommendedName>
            <fullName evidence="4">Cell surface protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        </lineage>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056933232.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606:SF1">
        <property type="entry name" value="CELL SURFACE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606">
        <property type="entry name" value="SURFACE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="47370" checksum="E9792AD5569180F3" modified="2023-11-08" version="1">MSNLINKVKDAVKGHSDNSHEESAHSSNQGPHDSNTANNADPRVDSDRDGRAAHTSTTSNMTPHNNTTSTGTSANAYDSTQSANHGPHSSNVANKADPRVDSDRDGRASNGHNSTSAGLGSHSASTGAGSGLATGAAAHEYGSHSTNQGPHDSNVANKADPRVDSDRDGRASYGHNTTGLGSNNNTTTTGTGIGSHSTTGHHGSQSGAGVGTGLATGAATGAAAHQYGSHSTNQGPHDSNLANKADPRVDSDRDGRASYGHNTTGTTGTGLQSSTSGTHGSHHGTSAGVGSGLAAGAAAHEVGSQSTHRGSNVSGTTGTGNVGMAGAGTEAGLTGHHGTMGGGPDATNSYATGPADNTAGPHKSDLANKADPRVDSDLSNSGHSFDQDVHKGSIGGAGVIPISGNAGPTSTKTFEEAQHAGSAGAGSSYNNSNTATTGSSATGPGQKTAGPHKSDMANKLDPRVDSDLDGSKTVGNAQQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXK7</accession>
    <name>A0A9X0BXK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_003781</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790924.1">
        <property type="nucleotide sequence ID" value="XM_056933383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXK7"/>
    <dbReference type="GeneID" id="81623632"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000040">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="114"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5488891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="319" mass="36481" checksum="92A53125EA249425" modified="2023-11-08" version="1">MPGLPTSIDLDECIARLYRKELLAESVIEAICAKTKELLMKESNVVHIKAPVTVVGDIHGQFFDLLEIFRIGGFCPDTNYLFLGDYVDRGLFSVETISLLVCLKLRYPDRVHLIRGNHESRGVTQSYGFYTECARKYGNANVWHYFTDMFDYLTLSVVINDEIFCVHGGLSPSIHSIDQIKIIDRFREIPHEGPMADLVWSDPDPERDEFSLSPRGAGYTFGAQVVRKFLEVNNMSHILRAHQLCNEGYQVLFDDRLSTVWSAPNYCYRCGNLASVLEVGDKMERFFNIFDAAPENDVHRSEQQAQQSRDSQPVIDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXZ2</accession>
    <name>A0A9X0BXZ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YMC020W-like alpha/beta hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_003859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791002.1">
        <property type="nucleotide sequence ID" value="XM_056933461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXZ2"/>
    <dbReference type="GeneID" id="81623710"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058934">
        <property type="entry name" value="YMC020W-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058933">
        <property type="entry name" value="YMC020W-like_ab_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349:SF1">
        <property type="entry name" value="AER328WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26147">
        <property type="entry name" value="AB_HYDROLASE_YMC0-YMC35"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="2">
        <location>
            <begin position="443"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="2">
        <location>
            <begin position="697"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5488969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="859" mass="93314" checksum="E3776ECF999DB525" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY50</accession>
    <name>A0A9X0BY50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489430.1"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
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    </dbReference>
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        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    <proteinExistence type="predicted"/>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040822638" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="265"/>
        </location>
    </feature>
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        <location>
            <begin position="33"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="265" mass="28108" checksum="C0C436520B96A2B5" modified="2023-11-08" version="1">MVAFTRLFTTGLLATSAMAAPIVQQRSSSGKRGAAYNDIGTVQPLSAAGTVSWAYNWAMSSWGQALPSNVEYVPMLWGAKDFGGWFAAIETALSSGSNYIMGFNEPDIGSQANMSPAQAAGYYQNYITPFSGKAKLISPAVSSSTNQGMGLSWMNEFLNDCASCGISGMAIHWYGETADQFKSHVSNALTMAASHGISEVWVTEFALNADVGGVTNPANTAAFLADVLPWLDAQPGVSRYSYFMCAENYLVNGNALNQAGQAYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYI1</accession>
    <name>A0A9X0BYI1_9EURO</name>
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        <submittedName>
            <fullName evidence="5">Polyadenylate-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_004308</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791451.1">
        <property type="nucleotide sequence ID" value="XM_056933910.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81624159"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="67"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5489418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="185" mass="20559" checksum="4BCEF2E8CD682B09" modified="2023-11-08" version="1">MSAEHTELKDEQLPPRDEGLDDEEEIAAMKRRVAEMESEAAKLRDMQETLEQQAEGLQENKEDIDARSIFVGNVDYGASPEEIQAHFQSCGSINRVTILLDKFTGQPKGYAYVEFAEPSLVAQALVLNESVFRGRNLKVTPKRTNLPGMTRGRGRGGFRGGRGRGGFRGSYRGGYRGRGRGFAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYW3</accession>
    <name>A0A9X0BYW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RAVE complex protein Rav1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792018.1">
        <property type="nucleotide sequence ID" value="XM_056932059.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81622308"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="2">
        <location>
            <begin position="596"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1296"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1302"/>
            <end position="1311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5490889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1335" mass="150904" checksum="431760DB089EA0C9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ20</accession>
    <name>A0A9X0BZ20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_002395</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791957.1">
        <property type="nucleotide sequence ID" value="XM_056931998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ20"/>
    <dbReference type="GeneID" id="81622247"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000003">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000012">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="10">
        <location>
            <begin position="48"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="11">
        <location>
            <begin position="254"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5490828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="459" mass="51298" checksum="D851A445698F3FB5" modified="2023-11-08" version="1">MPREIITIQAGQCGNNVGSQFWQQLCLEHGISQDGNLEEFATEGGDRKDVFFYQSDDTRYIPRAILLDLEPRVLHAIQSGPYRNIYNPENFFIGQNGVGAGNNWGAGYAAGEGVQEEIFDMIDREADGSDSLEGFMLLHSIAGGTGSGLGSYLLERMNDRFPKKLIQTYSVFPDMQTTDVVVNPYNSLLSMRRLTQDADSVVVLDNGALSRIVADRLHMRPGSVDDTTNFDQTNQLVSTVMSASTATLRYPGYMHNDLAGIIASLIPTPRCHFLLTSYTPFTGDSIEQAKTVRKTTVLDVMRRLLQPKNRMVSMIPSKSSCYISILNMIQGEADPTDVHKSLLRIRERRLASFIPWGPASIQVALTKKSPYLQHSHRVSGLMLANHTSVATLFKRIIQQYDRLRKRNAFLEPYRKEAPFAEGFGEFDEARAVVMDLVAEYEAAEREDYLDPGAGAEKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZA1</accession>
    <name>A0A9X0BZA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_003053</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792615.1">
        <property type="nucleotide sequence ID" value="XM_056932656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZA1"/>
    <dbReference type="GeneID" id="81622905"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="19"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="494"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5491486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="526" mass="56941" checksum="D3E4AEE0D3D666D8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZF0</accession>
    <name>A0A9X0BZF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 1-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_002785</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792347.1">
        <property type="nucleotide sequence ID" value="XM_056932388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZF0"/>
    <dbReference type="GeneID" id="81622637"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000001">
        <property type="entry name" value="Putative Elongation factor 1-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="8">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="7">
        <location>
            <begin position="141"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5491218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="227" mass="25028" checksum="E754295141DAA148" modified="2023-11-08" version="1">MGFTDFVSDAGLTLANNYLATRSYIVGDAPSQADVVTFKAFTAAPDAEKYPHVARWYKHIASYESEFTTLPGDSSKAFTAYGPESTEMPVNPKDKPEEDDEEDLFGSDSEEEDAAVVAERNKRLEEYKAKKAAKGPKPAAKSLVTLEVKPWDDETDLKQMEENVRAIEMDGLVWGASKLVAVGFGIKKLQINLVVEDEKVSTDALQAQIEEDEDHVQSTDIAAMQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZM7</accession>
    <name>A0A9X0BZM7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_001458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793092.1">
        <property type="nucleotide sequence ID" value="XM_056931061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZM7"/>
    <dbReference type="GeneID" id="81621310"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF1">
        <property type="entry name" value="PROTEIN TED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5492712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="68162" checksum="34851A9C22FAC4E8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZQ3</accession>
    <name>A0A9X0BZQ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_001399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793033.1">
        <property type="nucleotide sequence ID" value="XM_056931002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZQ3"/>
    <dbReference type="GeneID" id="81621251"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5492653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="266" mass="29617" checksum="015EA7E9CBF4E523" modified="2023-11-08" version="1">MASPVSHNASSLLLEPLPSLNVPLSRTSSKALRRIQFVGALRRWANFRIEGSQTYNSQTWNERELAARVSTSLQAGSVDEEHVLVSDEHGVQSRFEGRAEEVLGVAFEAQNQDLKLGGFRGASSLTPGYKKVPDFVLVISSREAKVVGEVKVPWINDHGLSKAISLSLFQTGDEEPFQHLLGQIAKYMFDSRLKYGVLTTYQLTIFLRKMDFGRAWGLGFSPVIHHNFRGSTSGRTISLCQSFYHVGLLALTDSQFDTQTGLRNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZS1</accession>
    <name>A0A9X0BZS1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_001297</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792931.1">
        <property type="nucleotide sequence ID" value="XM_056930900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZS1"/>
    <dbReference type="GeneID" id="81621149"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
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</entry>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF14">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040844983" description="Glutaminase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="3">
        <location>
            <begin position="106"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="333"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5493449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="687" mass="74649" checksum="A50E3150DB54BDCF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2I9</accession>
    <name>A0A9X0C2I9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_000230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794127.1">
        <property type="nucleotide sequence ID" value="XM_056929834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2I9"/>
    <dbReference type="GeneID" id="81620083"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5495114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="38044" checksum="FC4697E794773730" modified="2023-11-08" version="1">MSSEAPPPFRERMLGLLEPSQLMAMAISLGWVSAFMTRLWKFDFDLLACEPCILRLICIVFSTTLTEIGIDYMRVCVEAVKRGEVLAPITQTAKIRDEAFARFWIAFSTARTAAPAPNAPETSTTTEAEGPELVGSAALIPPLLRTASGVVLDIGPGTGSQMHLLRSPAITSIYGAEPCVGLHAELRARAAAEGLEAKYHVLSCGAASSELLPALEATGTGIVDAHNRDRSGVFDTILCVRVLCSVPQMERTTRELYALLKPGGRLLVTEHVVNPWRTAKGSFLARAAQAIYMMFGWRYFIGDCCMDRDTEGALRRAADQDGGWESAQLERSFGWSALPYISGVLVKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2X7</accession>
    <name>A0A9X0C2X7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_000650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794547.1">
        <property type="nucleotide sequence ID" value="XM_056930254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2X7"/>
    <dbReference type="GeneID" id="81620503"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5495534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="151" mass="16775" checksum="FEA0ED4DA8080239" modified="2023-11-08" version="1">MGRLHSKGKGMAASALPYSRAPPAWLKTTPDQVVDQICKLAKKGATPSQIGVVLRDSHGVAQVKIVTGNKILRILKSSGLAPELPEDLYFLIKKAVAVRKHLERNRKDKDSKFRLILIESRIHRLSRYYKTVGVLSPTWRYESATASTLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C329</accession>
    <name>A0A9X0C329_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_000876</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794773.1">
        <property type="nucleotide sequence ID" value="XM_056930480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C329"/>
    <dbReference type="GeneID" id="81620729"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="98"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5495760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="136" mass="15383" checksum="131ADEBFB9F391C1" modified="2023-11-08" version="1">MSLSEARPAKRARQACLTCRYVTDLDLEKRVVNFDKSNYSRKKTRCPGEKPVCSFCMRLGQTCTYGGVEVEERVPDSKSRLTKRVSELESELKRLADYVKHTSTEPNRSQSLPTVQEPNASPSFGPHEISRDASLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKS8</accession>
    <name>A0A9W9WKS8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutathione synthetase</fullName>
            <shortName evidence="9">GSH-S</shortName>
            <ecNumber evidence="9">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_008859</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9 11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="9"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785831.1">
        <property type="nucleotide sequence ID" value="XM_056938454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKS8"/>
    <dbReference type="GeneID" id="81628704"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="12">
        <location>
            <begin position="223"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="424"/>
            <end position="427"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5469241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="516" mass="57857" checksum="2DE9B4F0263B8BD0" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLD2</accession>
    <name>A0A9W9WLD2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inheritance of peroxisomes protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_009268</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for peroxisome inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786240.1">
        <property type="nucleotide sequence ID" value="XM_056938863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLD2"/>
    <dbReference type="GeneID" id="81629113"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005780">
        <property type="term" value="C:extrinsic component of intraperoxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024758">
        <property type="entry name" value="Inp1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12634">
        <property type="entry name" value="Inp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="188"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="396"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="511"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="433"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="511"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5469650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="696" mass="75919" checksum="80FAC30B22BD72E7" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WR35</accession>
    <name>A0A9W9WR35_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786683.1">
        <property type="nucleotide sequence ID" value="XM_056938301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WR35"/>
    <dbReference type="GeneID" id="81628551"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5472137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="221" mass="24267" checksum="5307CD06004D4713" modified="2023-11-08" version="1">MPFIVTSSDQKHRAASNDQNIWDGFFTRNTEKRLYSSTISHAVPCVLQEWGLCLIFMGIVINLVVLLVYVVVAYRVWSKRLLMGAMDDCGKACPDLDLQSTSNTFALPSRASIPGKSPYAVFTASLRLAKERQAEPSIQFASAHLLMRPMSSFLSSLQGRDPSHCQQSMPKQQQGQLAMVSVPKSRDSPTQIQVLHVPAAPGETIYGSVPIPGPYSSPMVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTC7</accession>
    <name>A0A9W9WTC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_008227</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786919.1">
        <property type="nucleotide sequence ID" value="XM_056937827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTC7"/>
    <dbReference type="GeneID" id="81628077"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000318">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF191">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5475161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="395" mass="43734" checksum="1042FA3F6B6BDC1F" modified="2023-11-08" version="1">MGTFTAAAIIAAYENIALDLGVSIQRVSYLTSLQIAILGGAPLLWKPLSHRFGRRPIFLLSLILSCACNIGCAKSPDYASMAACRALVAFFISPASAIGSGVVTETFFRHERARYMGIWTIMVTLGVPIGPFIFGFVAQRVDYRWIYWILAITNGVQAILYLFFGPETRYIGVDVQSESSAFKREYLSLGRIDPTPIKVSEFYHPLTLFTNIPVLLATVAYAMVFLFASVLNSVEVPQLLQQKFELNAQQLGLQFLGLIIGTILGEQLGGFMSDMWMNARARKIGRKPEPEYRLWLSYIGFLLTIAGMVVFLVCTEQATVGQWNVKPVVGTGIAAFGNQVVTTVMTTYAVDTYPQDAGSVGVFINFVRSTWGFIGPFWYVRPGQDICFSYGQKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTH1</accession>
    <name>A0A9W9WTH1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pirin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_008147</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786839.1">
        <property type="nucleotide sequence ID" value="XM_056937747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTH1"/>
    <dbReference type="GeneID" id="81627997"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="4">
        <location>
            <begin position="21"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="5">
        <location>
            <begin position="176"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5475081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="303" mass="33369" checksum="2EEC811EC59729BB" modified="2023-11-08" version="1">MTARPIRQILHAIEQSEGAGARVRRSIGTPSLRNLSPFLMLDHFTIGKGAGFPDHPHRGQETITYLLSGGVDHEDFAGNRGTIGPGDLQFMTAGRGIMHAEMPHENEDGAPNVGMQLWVDLPRALKMCEPRYRDLRAEEIPLVKTDEGRVEIKVISGQSHGVDSVRDLAYTPVWLLDVTIRPGGTVRQILPTGWNAFAYTLAGTTVFGGGEQTKVVDEFYNVVFEQEGDLVEAFVPEGEGAGKEARFLLVAGQPLDQKVVQYGPFVLNSQEEVYQALMDYQTGSNGFEKSRNWQSEIGKRMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTI3</accession>
    <name>A0A9W9WTI3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytokinesis protein sepH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5474953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786711.1">
        <property type="nucleotide sequence ID" value="XM_056937619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTI3"/>
    <dbReference type="GeneID" id="81627869"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5474953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="341" mass="38837" checksum="0B70926B5371148C" modified="2023-11-08" version="1">MRRPRPAVLYKENSVEDYSDLIMANEDVLDRSSEYFTNWTMTLTLRHTTKTGISRMNWLAIIRNYENSSNIARDKYARLRNQVEDLVGSLKTSQDEDVLAEISEQLLTVVVNAIIYNDYEIQENPCFVGGIPIQMFQTSTLTLQMFISAGGLNVLVEFLEDDYEDERDLVLIGVNGICRVCLSCRDLRRKTIFARILSRNSVLDPLSLVLSRVLDEDGELAEVIEGRIANTFFIFSQAENHVKEMVAERTSGPLTVLAGVLKELRRMSPVHQVTMLKFIQNLSMLSTTLDALQNSNAIDVLTELLQSTMGRSHFREVSNQILNTIYNMSFEQDSTGRRSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTN1</accession>
    <name>A0A9W9WTN1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SWI5-dependent HO expression protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787021.1">
        <property type="nucleotide sequence ID" value="XM_056937929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTN1"/>
    <dbReference type="GeneID" id="81628179"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5475263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="44899" checksum="0692B76956FA98ED" modified="2023-11-08" version="1">MVKLRHRIATPHLALLKFETKGMAPFSFPSPSAHPDTLGRSPPPPYPSPWRAINPRRKRSLTNSPTEDAPQVNLARVDTQLNMHQFNNLFEEDAGANGSKDSNSLSSQPILASPYLGNELPAEWSAVGHAAATGKSGRVIHSLQEEVARQKREAALWQSRAEESQRTNETLKFQLQNTTDRLSHLEQVNETNGKLIERKDRKIEDLRAELHTERTKRLDAQGVANETNETMRVERENHHREMARLQEEAKYHENQYEVLFRAMKQDKADLTRRMDALHTQLAQLKETQVSQNEAATRLLTVDDQRQRLVSSLQERHEQMMALHQRYKEIKEQEFQDVLGQARVNGDRIDASLKDLKETEDKMKWVIRMSEVQQGQRGDDNSATGRSLAGTPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTS7</accession>
    <name>A0A9W9WTS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787113.1">
        <property type="nucleotide sequence ID" value="XM_056938021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTS7"/>
    <dbReference type="GeneID" id="81628271"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5475355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="67" mass="6892" checksum="B6C790E2F7C1B319" modified="2023-11-08" version="1">MTAPSPPQALAQPVTSASALFDCPLSKIPLMQVAGFRCRPLPVGCAKVTEESAPGNGRCRAALLRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUD7</accession>
    <name>A0A9W9WUD7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Delta(3-5)-Delta(2-4)-dienoyl-CoA isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_007991</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787457.1">
        <property type="nucleotide sequence ID" value="XM_056937592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUD7"/>
    <dbReference type="GeneID" id="81627841"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000024">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5475704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="283" mass="30797" checksum="A11EB9EDB1B749CE" modified="2023-11-08" version="1">MASSYSFKYFNVRFPEHHPYVAHVEINRAEKMNAFFEAMWLELRQVFNQLSEDSMVRAIVLSGAGEKAFTAGLDVKAASQGGALADGQSTVDPARKAVHLRRHVLEFQDCITSVERCEKPVIVAMHGFALGLAIDLSTAADVRLCSKDVRFAVKEVDIGLAADIGTLSRLPKVVGSSSWVKEVALSARIFGADEALRVGFVNAVYENRTETISAALKLATLIASKSPVAVQGTKEILNWSRDHSVQDGLRYTGVWNSAALQTADVSAALLSGLQKRTPTFEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUR5</accession>
    <name>A0A9W9WUR5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_008013</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056937614.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="CYP59-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5475726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="515" mass="58609" checksum="564B3F08D0BAEF4E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUR8</accession>
    <name>A0A9W9WUR8_9EURO</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Penicillium diatomitis</name>
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            <authorList>
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        <source>
            <strain evidence="1">IBT 30728</strain>
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    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PANTHER" id="PTHR37540">
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        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5475673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="579" mass="66488" checksum="55883082CCBE3440" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUS8</accession>
    <name>A0A9W9WUS8_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">N7539_007764</name>
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        <name type="scientific">Penicillium diatomitis</name>
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                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
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        <location>
            <begin position="17"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="315" mass="30703" checksum="F8C1B250E8ACACF7" modified="2023-11-08" version="1">MKSFAISAAILASVAAALPASVVSNVASGVLSTPSYTSSGVPVISNLPSSVNVATEGYSAQASAGAAQVSTGQIPSQASGLVDGKVNNVLGVTDQAGKLVKVVLEPTVANLLAGLNLGGVVQSVGQIVQVAPTLHELNLDGVTGTTLTVATGTGGVALVKVNSLVEGLLSGLGLGQTGSLVGSIVGNVEGVVSGAGSTAKRDGLPSKVMTITNLHGLPLHIQLNQSILNLLGGLDLSSVQGVVGTVVAEVPVVSQLAGAAQNVDADQNQLFGVLGQDGVSALLVKVEGTVTGLLSMLGLSSLTTTVGSVVPAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUX9</accession>
    <name>A0A9W9WUX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">N7539_007276</name>
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    <organism evidence="2 3">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477132.1"/>
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    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="773" mass="85817" checksum="9F82283A9F95EC9E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV24</accession>
    <name>A0A9W9WV24_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_007417</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787817.1">
        <property type="nucleotide sequence ID" value="XM_056937018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV24"/>
    <dbReference type="GeneID" id="81627267"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000037">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF49">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="584"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="394"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5477273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="593" mass="67738" checksum="27935D29144C40FA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV28</accession>
    <name>A0A9W9WV28_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proteasome subunit beta type-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_007397</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787797.1">
        <property type="nucleotide sequence ID" value="XM_056936998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV28"/>
    <dbReference type="GeneID" id="81627247"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03757">
        <property type="entry name" value="proteasome_beta_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000027">
        <property type="entry name" value="Proteasome subunit beta type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5477253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="260" mass="28246" checksum="36F4006F5EB268D2" modified="2023-11-08" version="1">MTSLVDHSARETVGFSFSEATAAGAKQHGFYPYTDNGGSTLGITGSDFAILAGDTRSTSGYNINSRMVPKVFKIGGDEETGEGARIMLSVVGFAADGTALKERLDAMVKMYKYKHGKPMSVAACAQRLSTILYEKRFFPYYVHAILAGLDEEGKGALYSYDPVGSYEREQCRAAGAASSLIMPFLDNQVNFKNQYIPGSGEGHALVARKPEPLPLETVKGLVRDAFTSAVERHIEVGDNLQMLIITKDGIQETFHPLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV79</accession>
    <name>A0A9W9WV79_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_007443</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase VIIa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787843.1">
        <property type="nucleotide sequence ID" value="XM_056937044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV79"/>
    <dbReference type="GeneID" id="81627293"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.91.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039297">
        <property type="entry name" value="COX7a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036539">
        <property type="entry name" value="Cyt_c_oxidase_su7a_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02238">
        <property type="entry name" value="COX7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5477299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="76" mass="9136" checksum="A38BE4C5B9B94C98" modified="2023-11-08" version="1">MFRTAPRMAGFVFRENRVPYYQRLFQNHDGKRQWWKTSRSGYIMYPYLVTVYGLGAATTYAMCRMVFGKKTWFGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X227</accession>
    <name>A0A9W9X227_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_006616</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788152.1">
        <property type="nucleotide sequence ID" value="XM_056936217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X227"/>
    <dbReference type="GeneID" id="81626466"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF110">
        <property type="entry name" value="UBID FAMILY DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="29"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5480722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="406" mass="46506" checksum="ED8E9FC1F92D7486" modified="2023-11-08" version="1">MGDTSPTPQQLLVEAIVFWAIGVVLYIGRMVSRAIAGGSIKRLFWDDYVMTATFMIYTTLLVLIQISARYATNLMDPKDYDTVLSDPQQVSDRIFGSKIVIGLEQCMLISTWGVKACMLILYWRITQNLRSNFYIKLLCIYVATGFIVIMVTYYAVYCRPFSQYWAMPVDNMQCATYQYYSITQAVFNISSDAMMFAVPIPLLVKAQLKRRRKVVLLGVMSLGLFTIIAAILNKYFNFASPLTTTYQIWYIRESSTAIYVANLMCWWPLLRKLFGLKAFAYNSNRGNKGPNHRQLNKGGRGYSDGSESRPSVSYSRPLRFMQSPFRKGYRTGHAQRHGDTRRSSQEAITRASINFTDDLHRTDTIAMDDWDCERKQSVNFVDLKGSRHDSITDLEAGYMKPLSRPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2D5</accession>
    <name>A0A9W9X2D5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788570.1">
        <property type="nucleotide sequence ID" value="XM_056936635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2D5"/>
    <dbReference type="GeneID" id="81626884"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF2">
        <property type="entry name" value="PHAGOSOME ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5481140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="500" mass="54716" checksum="C3973CE684D6550F" modified="2023-11-08" version="1">MTVVANREKALGASLHNVLTRVKSHPQIYPEIDLVYSSANPLHDPIVLKLPANGLRLRFDGPDQRLRLIEVLDFSRANLVYKNQEVVKASKTGDMSSTSQGPGFRHVYNRLFGPSYPGEYVPPTDPHAQYGTYVLSYPGVAFSFPLQHSAWSESCDFVALLSSSAALSATSMSIFQGPSWPEVRAKLFIQQPQYPRSSTVMGKSRDVLADEVEGFHIFGAGKLEVERRNSPPAQIVLGETTAQDLIAEFGPPDAIYRKHDRRISIHRAASGLGAGEALHLGSLPGTGLEIADTDHSSNNSITDDSDEEVSSNNISDPTSLPAESFFNYFHHGFDAFISYPATPGPAFPLSSLPEPSSQPSASQLTVTKIILHGNVPGSYPFNRHRRSRWTIHLDSSDKTLNSETPYDEISQTLRDVWRGSEAGVSGRRDMQRPMVLNRGWGDSPESSVEFLGGWEESMARGPRNVSDGHDGGLGNTELFGFPGLLFEVLKNGSVSCLTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2N4</accession>
    <name>A0A9W9X2N4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_006175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788701.1">
        <property type="nucleotide sequence ID" value="XM_056935777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2N4"/>
    <dbReference type="GeneID" id="81626026"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF19">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="35"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="585"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="593"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5482729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="676" mass="76901" checksum="D6A84871ADB4EA61" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2W5</accession>
    <name>A0A9W9X2W5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_006986</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788522.1">
        <property type="nucleotide sequence ID" value="XM_056936587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2W5"/>
    <dbReference type="GeneID" id="81626836"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="105"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5481092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="551" mass="60072" checksum="2A60E15926486921" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2X7</accession>
    <name>A0A9W9X2X7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_006174</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788700.1">
        <property type="nucleotide sequence ID" value="XM_056935776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2X7"/>
    <dbReference type="GeneID" id="81626025"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF108">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="79"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5482728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="368" mass="40546" checksum="0539FA4ABA98B4F5" modified="2023-11-08" version="1">MASSHPYSAINTINLATQCLCIPIVSIFVALRFYVRFRFRMGLGAEDCKFFASGGLGIVSSIIVALEANLGYLALDACAVAWALFIAYCAIGIVLGQNGGGYHFDELTPDEQTNFKKFTWISTIIYCPMALCVKIALLAILTRIFAPYRGKVWFIYILLAGLCIYYTIALVIKIRICNPVSLYWQGTKEEIEDSCLDQRAAFLADAVISAISDMVILVLPLPLTWSLQMSRNRKLRVIGILGAGGLATGFSIYRVVLVSRDQESYDLSMFFIRVIMSGNAEAGIGLVCACLPTVNILISHYRKASSSKRYDSSNSLVQMRARKSPHPAHSASHVSTIHDYESQTDHSHFTTASGALHGIEPVRTEDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X316</accession>
    <name>A0A9W9X316_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Developmental regulatory protein wetA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_006272</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the wetA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788798.1">
        <property type="nucleotide sequence ID" value="XM_056935874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X316"/>
    <dbReference type="GeneID" id="81626123"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040112">
        <property type="entry name" value="WetA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934:SF25">
        <property type="entry name" value="DEVELOPMENTAL REGULATORY PROTEIN WETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934">
        <property type="entry name" value="PROTEIN ESC1/WETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0183">Conidiation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="242"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="318"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="391"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="465"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="263"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5482826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="517" mass="56067" checksum="D7BD738C838727CB" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X387</accession>
    <name>A0A9W9X387_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-oxo-L-prolinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_006524</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789050.1">
        <property type="nucleotide sequence ID" value="XM_056936126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X387"/>
    <dbReference type="GeneID" id="81626375"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="234"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="5">
        <location>
            <begin position="538"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="735"/>
            <end position="1271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5483078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1277" mass="138557" checksum="7B69D7FC5EB96BE3" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X587</accession>
    <name>A0A9W9X587_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial phosphate carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_005909</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transport of phosphate groups from the cytosol to the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789383.1">
        <property type="nucleotide sequence ID" value="XM_056935511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X587"/>
    <dbReference type="GeneID" id="81625760"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035434">
        <property type="term" value="P:copper ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000076">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000131">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF13">
        <property type="entry name" value="PHOSPHATE TRANSPORTER PIC2, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="33"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="127"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="228"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5484113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="321" mass="35553" checksum="DA38ECA64D316858" modified="2023-11-08" version="1">MATQERKLPFGKIEPNSMKYFLSCGLGGIIDQCMGLSTPIAHLLLPGPTHTAVTPLDLVKCRRQVDPKIYSSNISAWRSIFAKEGLRGVFFGWSPTFIGYSFQGAGKYGLYEYFKHLYGDTMFPETNRTLVFLGASASAEFFADMALCPLESIKVRMQTTLPPYANNLREGWSRVVAKEGISSLYKGLYPLWARQIPYTMTKFATFEETVNQIYRYLGKPKESYGQLTQTGVSFLGGYIAGIFCAIVSHPADVMVSKLNADRKPGEGAMKAVSRIYGNIGFSGLWNGLPVRIVMLGTLTGCQWLIYDSFKVFLGLPTTGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X589</accession>
    <name>A0A9W9X589_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sphingomyelin phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_006075</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Converts sphingomyelin to ceramide.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000007">
        <property type="protein sequence ID" value="KAJ5483875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789145.1">
        <property type="nucleotide sequence ID" value="XM_056935677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X589"/>
    <dbReference type="GeneID" id="81625926"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045473">
        <property type="entry name" value="ASM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011160">
        <property type="entry name" value="Sphingomy_PDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF34">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000948">
        <property type="entry name" value="Sphingomy_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040782317" description="Sphingomyelin phosphodiesterase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="14">
        <location>
            <begin position="149"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin phosphodiesterase C-terminal" evidence="15">
        <location>
            <begin position="453"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="43"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="171"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="553"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF19272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5483875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="630" mass="69749" checksum="9784238FCC423E3A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5Z8</accession>
    <name>A0A9W9X5Z8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="81625925"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5483874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="88" mass="10420" checksum="E290A77EE94CE830" modified="2023-11-08" version="1">MYPQLWGHYIDIVSQATGPKWYQSSSPFKEFETFKPQQKPQETYQQPSDEGIPFPATWRPPQIRQTEIWSTSKGAKRLQLPYWDASRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6G3</accession>
    <name>A0A9W9X6G3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789740.1">
        <property type="nucleotide sequence ID" value="XM_056934546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6G3"/>
    <dbReference type="GeneID" id="81624795"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription factor TFIIIB component B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bdp1_fungi"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like_sf"/>
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        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037327">
        <property type="entry name" value="TFIIIB_Bdp1_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="485"/>
        </location>
    </feature>
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            <end position="306"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="382"/>
        </location>
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            <begin position="532"/>
            <end position="599"/>
        </location>
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            <end position="10"/>
        </location>
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            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="546"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5484956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="599" mass="65024" checksum="22F0B491298E13CE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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    </gene>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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            </authorList>
        </citation>
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        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1304"/>
            <end position="1615"/>
        </location>
    </feature>
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            <end position="1501"/>
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            <begin position="1022"/>
            <end position="1031"/>
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    </feature>
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            <begin position="1032"/>
            <end position="1042"/>
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            <end position="1061"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        <location>
            <begin position="1325"/>
            <end position="1332"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5484735.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7H2</accession>
    <name>A0A9W9X7H2_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
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            </authorList>
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        </source>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">IBT 30728</strain>
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    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="81623567"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
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            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
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        <location>
            <begin position="263"/>
            <end position="348"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="21"/>
        </location>
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        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5488826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="348" mass="39300" checksum="625039F70551743F" modified="2023-11-08" version="1">MPPKKAEQPKKKKATVDDKTFGMKNKKGGAAQKQIQQLQAMAKSNKDPDAKRKEAEKLKREAEKKAAEQAKKEAAELFKPVQVQKVPFGVDPKTVLCVFHKKGGCDKGKKCKFSHDMNIERKAAKKDLYTDSRDAEEGEDKKKADTMDNWDEEKLRSVVLSKHGNPRTTTDKVCKYFIEAVENQKYGWFWVCPNGGDKCMYKHSLPPGFVLKTKEQRAAEKALMDKSPLNTLTLEDWLESERHKLTGTLTPVTPESFAKWKTERLSKKAAEEQAQKAKEATGRAMFESGDWKDEESSDEEEDDDTWNLDALRDETEQLKERTEEERVAKLTGVDVPSDGGATVQQAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEE0</accession>
    <name>A0A9W9XEE0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Fungi</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="5"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="358" mass="42290" checksum="5B0200E17A6AAC4E" modified="2023-11-08" version="1">MTEVFHLFLELPFELRRMIWKECLPKSRVFDTMLPCLVYEKSRCRGTRWSSRQSWRPPIITRVCRESRAVAHETGRVLFYGDDPNVPDYIDSVWSDATTDIVAQYWCPGLESVMFWPHDEPDTYLFHYAPRYRGTLIAEARLSRALRSPTPSADWSTLSQLQHCYVCLENPVMIHLTRKELLLSGLFGRLGEEFIQLVDPTDVSRLKKFHNLALTSSQQLPETLEFFEQLHTSTSQYKIHNWARETLIRWIYQEWLQAKQTSFVGIPHPERIWLGPRSPGVDEKPFNPMAPETYSKYSMWFHLSDTMHFLYDEKHPWVKEKLAKAPRFLPRIMIRPCIKRCWFPPRRLGVGGREDIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEG5</accession>
    <name>A0A9W9XEG5_9EURO</name>
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            <fullName evidence="2">DUF7905 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">N7539_004137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
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            <end position="718"/>
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    </feature>
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            <end position="63"/>
        </location>
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            <begin position="201"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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        <location>
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            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="774" mass="87022" checksum="9B3B3E06D952E299" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEQ5</accession>
    <name>A0A9W9XEQ5_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002369</name>
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    <organism evidence="2 3">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5490802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
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    </feature>
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            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5490802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="228" mass="32763" checksum="C605E2E6DF6A00B3" modified="2023-11-08" version="1">MLIPKLPTSVWYVVDDYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYSYYYSYYYSYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYSRLHPIPFTTCGGLQKKVVFLPILLRSTISVMAGDQTPTRDRTPWRMQSICTFQPLTTTMVAIVALRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFG7</accession>
    <name>A0A9W9XFG7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_002867</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792429.1">
        <property type="nucleotide sequence ID" value="XM_056932470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFG7"/>
    <dbReference type="GeneID" id="81622719"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5491300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="116" mass="13522" checksum="CCA3903C22F7BEEC" modified="2023-11-08" version="1">MTWQPKLRPKGFPHSLDDFALASLTELEHRSRTGEDKRDQRVFRVKRKHVLKACDRCRVKKTKCDGKQPCNRCSVYNHPCLFRERKATQTKVYSRGSVKIHMGFRINQSPSASVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFK2</accession>
    <name>A0A9W9XFK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_002922</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792484.1">
        <property type="nucleotide sequence ID" value="XM_056932525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFK2"/>
    <dbReference type="GeneID" id="81622774"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5491355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="547" mass="60955" checksum="85F909D2FEFC3ECF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFW6</accession>
    <name>A0A9W9XFW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MICOS complex subunit MIC10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_002419</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Mitochondrion inner membrane</location>
            <topology evidence="2 9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the MICOS complex subunit Mic10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791981.1">
        <property type="nucleotide sequence ID" value="XM_056932022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFW6"/>
    <dbReference type="GeneID" id="81622271"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007512">
        <property type="entry name" value="Mic10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304:SF0">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04418">
        <property type="entry name" value="DUF543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5490852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="91" mass="10067" checksum="C671086F24EED9DA" modified="2023-11-08" version="1">MADSSETRPVARATKPVSEALLNEKWDRAISSMIIKSSLGLSFGVVFSVLLFKRRAWPAWVGLGFGAGRAWEEADASFRRGDSPVRDALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFY6</accession>
    <name>A0A9W9XFY6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ZIP family zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_003117</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792679.1">
        <property type="nucleotide sequence ID" value="XM_056932720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFY6"/>
    <dbReference type="GeneID" id="81622969"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF60">
        <property type="entry name" value="FAMILY ZINC TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5491550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="55661" checksum="136E7E09AA0ADF05" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG82</accession>
    <name>A0A9W9XG82_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="15">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="15">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ALA1</name>
        <name evidence="17" type="ORF">N7539_003133</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 15">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="15"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG82"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000003">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059090">
        <property type="entry name" value="ALA1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26023">
        <property type="entry name" value="ALA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 15 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="16">
        <location>
            <begin position="10"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="603"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="607"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="722"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="726"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5491566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="960" mass="107313" checksum="5AD55678BE32E19C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGF0</accession>
    <name>A0A9W9XGF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peroxin/Ferlin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792577.1">
        <property type="nucleotide sequence ID" value="XM_056932618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGF0"/>
    <dbReference type="GeneID" id="81622867"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052646">
        <property type="entry name" value="Peroxisomal_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="7">
        <location>
            <begin position="300"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="435"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="437"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="474"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="507"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5491448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="589" mass="66036" checksum="5B82A478CE4C5C8C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGR1</accession>
    <name>A0A9W9XGR1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792712.1">
        <property type="nucleotide sequence ID" value="XM_056932753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGR1"/>
    <dbReference type="GeneID" id="81623002"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5491583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="118" mass="12970" checksum="63A3854C6F97AB8E" modified="2023-11-08" version="1">MSKALSNFAQLAQSIKNGPAKFSGAAAEGSRLIPSRTKDEQFQFRIDAGHYDGSTKHLHVNLQVNSQAKSPALKDWVKKNTTHEKLATATFDTTAEDKNAEYARVVNELVRIGKQKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGR7</accession>
    <name>A0A9W9XGR7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component SEC15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the SEC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792726.1">
        <property type="nucleotide sequence ID" value="XM_056932767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGR7"/>
    <dbReference type="GeneID" id="81623016"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.30:FF:000004">
        <property type="entry name" value="Exocyst complex component SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.670:FF:000004">
        <property type="entry name" value="Exocyst complex component SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="7">
        <location>
            <begin position="46"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="6">
        <location>
            <begin position="397"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5491598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="761" mass="86786" checksum="822D2CE2E461A245" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH96</accession>
    <name>A0A9W9XH96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_001599</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ARPC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793233.1">
        <property type="nucleotide sequence ID" value="XM_056931202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH96"/>
    <dbReference type="GeneID" id="81621451"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5492853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="193" mass="20587" checksum="603142904B88118B" modified="2023-11-08" version="1">MSLLNYRTINVDQLDPESSVNFPMETLLPATLPQPETSSDAANIASQIRQLLRSGDTVGALRQVLDTAPLGGDDRAKEVHLGTVIEVLQGIRQAEMTRVLEDVVSGDGGSERADCLMKYIYKGMSSSGASGGASTPRKIDSPQATGFSQIQARNAGEGGGGQQMSVLLNWHEKLVELTGTGSIVRVMTDRRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHL3</accession>
    <name>A0A9W9XHL3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="1">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_001904</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793538.1">
        <property type="nucleotide sequence ID" value="XM_056931507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHL3"/>
    <dbReference type="GeneID" id="81621756"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF904">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="47"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5493158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="629" mass="70133" checksum="7BBF977C30365490" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHU0</accession>
    <name>A0A9W9XHU0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Telomere replication protein EST3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793180.1">
        <property type="nucleotide sequence ID" value="XM_056931149.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81621398"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="857"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1173"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="725"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1179"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1343" mass="148781" checksum="1CAF5A0C4C3AB8F7" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI24</accession>
    <name>A0A9W9XI24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_002123</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
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            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="291" mass="32631" checksum="0F02E9FC3CAD1B5D" modified="2023-11-08" version="1">MLVTSASESLVGDPLALFVQLGPSVYMHDPKSGTAPNDGQPVILLAFWMDAPARALSKYVVEYTRIVPSARIIFLRSASNDFFLHATARAQQARLGPAIAALRSSVTPDCPVFMHIFSNGGLFRTTHLLKAYRQATGRPLPISSMVIDSAPGTASIIAAMKAFSFAMPRFWILRWLSKGILLMMLAVIKLYQTSFRIPNAIKVAREEINDQNLVQPANAEGTLTRCYIYSSTDELVDWRDIERHASDSEACGWTVHRERFHGTPHVGHMRVQPERYWSIIREHLQLKKPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
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        <location>
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            <end position="497"/>
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        <location>
            <begin position="65"/>
            <end position="502"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5492934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="525" mass="58344" checksum="D28E16B9FBF06CBE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XII2</accession>
    <name>A0A9W9XII2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
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</entry>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="89"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="668"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="910"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="682"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="722"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="756"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5493459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="951" mass="105278" checksum="AA5E933144AE7534" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XL51</accession>
    <name>A0A9W9XL51_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_000100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793997.1">
        <property type="nucleotide sequence ID" value="XM_056929704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XL51"/>
    <dbReference type="GeneID" id="81619953"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029225">
        <property type="entry name" value="Nse4_Nse3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15412">
        <property type="entry name" value="Nse4-Nse3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nse4/EID protein Nse3/MAGE-binding" evidence="10">
        <location>
            <begin position="137"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="9">
        <location>
            <begin position="334"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="180"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5494984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="437" mass="49891" checksum="D04B5083BC44F9E1" modified="2023-11-08" version="1">MARYPQSQLDEDAARDLSPTSSNSSSEKENRRQRPRKRPPVPMSAARGQPKRRRLVDRTTNIQSQPASQRKDRRFYDPDQPEEERRHVRKIYRDLTTDFNDSRSEYLQPGNNGIFKTLETANGLFAKVKQTSDATIDSRLLVSAADLTHKKTAQLALGDASAGIDVDEFVSKCISYMRRGPDLSDGNTQRRQRVRQTQRDPNDSDDGDTGDAMNWDWLGRMACSHTNSRPAVSGFLLGPLSVQKRVRQMTQRTGRERPEDTQIVQPAELRQDELGQQDDSNLTLMCARINETLNRTIEETEDKVNRILSAEEAPTMERIQEVMFRHHTSPSGGICLFNFCINPRSFGQSVENLFYVSFLVRDGYAGLKMSDYGTPALQYATPYPPHEAQAKKIQKHQAIFSLDFDSWAEIVREFGIKKSIIPHREEKEEGNSQTWYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLC3</accession>
    <name>A0A9W9XLC3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_000224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794121.1">
        <property type="nucleotide sequence ID" value="XM_056929828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLC3"/>
    <dbReference type="GeneID" id="81620077"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5495108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="94" mass="11018" checksum="8971965BF41BA36A" modified="2023-11-08" version="1">MIDHCIKLSETLDDTQAQSDGGGERVRPLAVKRSCLDSYMRDQIFVFEELGRLGNTSDHQHFRGEMTELTEDRRYWTLHTETAHWVCRETLFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLM1</accession>
    <name>A0A9W9XLM1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3 11">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_000372</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3 11"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794269.1">
        <property type="nucleotide sequence ID" value="XM_056929976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLM1"/>
    <dbReference type="GeneID" id="81620225"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="12">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="9">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5495256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="151" mass="16515" checksum="1616FC9E165571B8" modified="2023-11-08" version="1">MADEQTFIAIKPDGVQRGLVGPIISRFENRGFKLVAMKLTSPSQEHLEKHYADLAGKGFFKGLISYMLSGPICAMVWEGKDAVKTGRTILGATNPLASAPGTIRGDYAIDVGRNVCHGSDSVENAKKEIALWFSPSEVLNWKATQAQWVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLS1</accession>
    <name>A0A9W9XLS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="81619879"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5494910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="187" mass="20777" checksum="4D8A9375CFC596B0" modified="2023-11-08" version="1">MTGQESASLVFPVLCLVVSFAIFCLIHSTEISQLLRALKRSTADYLREARRRFSSLPHYDFLGRDSTPSSHYHTTLGSASVSDLTALDTFGSNLIPSSNLDLDPDSESMFAPDASDTSSDGTLRTRNNDSHPPSDSWEIELEERILNGRGMGPWLDRVIDRVVQRVIENLVSDEYAELDISTHATSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMF2</accession>
    <name>A0A9W9XMF2_9EURO</name>
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        <submittedName>
            <fullName evidence="9">Meiotic coiled-coil protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_000714</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056930318.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81620567"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF48">
        <property type="entry name" value="MEIOTIC COILED-COIL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PUM-HD" evidence="8">
        <location>
            <begin position="424"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="487"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="523"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="715"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="62"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="241"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="803"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="804"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5495598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="824" mass="91075" checksum="83F7AB5303C1B54E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMQ7</accession>
    <name>A0A9W9XMQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA 3'-terminal phosphate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794122.1">
        <property type="nucleotide sequence ID" value="XM_056929829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMQ7"/>
    <dbReference type="GeneID" id="81620078"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="345" mass="37590" checksum="75493E843D5C712A" modified="2023-11-08" version="1">MSSFKNLENAAFETSDVAPHISPHIHIDSRTLGCGGQLVRITRGLSALAVKILAEISGSHVTNDLVGARSITLTSPQAEKTSDPATASQTPKGQYQRLNAALMPLNGVSVNSEPCIPKIHVGARASTKVVKVNIVGGTNGSGCPSYDYISQVIEPNFARLGLPALSVKLHKRGWATGSLSMGEMSFFIRPLPTSESCFSEGLSPTSRFPMIDLMSFERGQVTRIDVIVLAPRDTLPQNERNGSCLTVPDHIERETHRRLRKALRTIESSVLAESADGTSTVPINTHLTEVTSHFCQIFLLLVAHSSNGFRIGYDTLLFDVDKPRRKARRESWTNIKRPGKGRINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMX8</accession>
    <name>A0A9W9XMX8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_001047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794944.1">
        <property type="nucleotide sequence ID" value="XM_056930651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMX8"/>
    <dbReference type="GeneID" id="81620900"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5495931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="77" mass="8540" checksum="170626876BF36984" modified="2023-11-08" version="1">MAPKSLWTTARPLVLDELEARASDLASAHGRDVIAPGEPIQKMELILRHLAQRLSKTNASASFLSSPSTRKTSKWLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XNG7</accession>
    <name>A0A9W9XNG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_000600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794497.1">
        <property type="nucleotide sequence ID" value="XM_056930204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XNG7"/>
    <dbReference type="GeneID" id="81620453"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5495484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="84" mass="9170" checksum="F90E1C4467D01655" modified="2023-11-08" version="1">MRTGISDIGVRSVAHLDQKSNLFRKSSEAIATIEPVGIVFLMNLEYTSLESIPKLCHYTPQSGAYSGAYSERPTLVSHDQTAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJH2</accession>
    <name>A0A9X0BJH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_009082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786054.1">
        <property type="nucleotide sequence ID" value="XM_056938677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJH2"/>
    <dbReference type="GeneID" id="81628927"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5469464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="143" mass="15239" checksum="07861ABE5217368D" modified="2023-11-08" version="1">MVTVAPSALSLSIIPAPIVLPPLDWISDTQPLFHPQGQIAVVLRASREPMLPRSESPCGPLYPVRVMALAHCLLLMIKLHHDLEVRRHLATSPAERISATISWLRCLDTPATSGSAPAAATAAAAAAVQAQACRATIQRTQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJI1</accession>
    <name>A0A9X0BJI1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">N7539_009244</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786216.1">
        <property type="nucleotide sequence ID" value="XM_056938839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJI1"/>
    <dbReference type="GeneID" id="81629089"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000152">
        <property type="entry name" value="Cell wall glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF27">
        <property type="entry name" value="GLYCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 22" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 20" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040901273" description="chitinase" evidence="20">
        <location>
            <begin position="20"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="21">
        <location>
            <begin position="42"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ5469626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="366" mass="40760" checksum="0C525FB8FAF6BA5A" modified="2023-11-08" version="1">MRHFWTTAAWASLMGSVVAQTFTNCNPLEKACPADPALGTEHEWWLNSTIDPSVWNMSTGSINYANGAAEFTIAKVNESTLMQSNFYIFFGVVESWVKMAKGGGVVSSVVLESDDLDEIDWEWVGYNTSAVQSNFFGKGNTTSYDRGGIHYVPNADTEWHNYTTLWTSEKLEWHIDGQVVRTLPFNDPKALGGKNYPQTPCRVKFSNWPAGREGAAQGTIEWAGGLVDYSKGPFTMSVQRIRIQDYHSGKEYSYGDRSGSWQSIKVVTGNSTVQQKIDQPPPKSLSEKWADLPQATHIGVYAAAGAVGGLLILVLGFCCIRQRRQGRLEHALADSKWNAERTEMANFQSDWKQTEWKHGGYSKVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BM38</accession>
    <name>A0A9X0BM38_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6606 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786468.1">
        <property type="nucleotide sequence ID" value="XM_056938086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BM38"/>
    <dbReference type="GeneID" id="81628336"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046541">
        <property type="entry name" value="DUF6606"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20255">
        <property type="entry name" value="DUF6606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6606" evidence="1">
        <location>
            <begin position="15"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="160" mass="17989" checksum="995DE806220498CE" modified="2023-11-08" version="1">MDHTSLQDIQGTSYLFHHIFLPPKLPQEDDYCVGHEFLLTDVVIDALCQFKSYFSSDEAEVIGVALTMITRLRQVYGHNGEVDEGQFNNALKELKEEGELYFTIHGTVALVNKNLGGFLPIYVHEQNAAILISNKGTRTHIECFELSPVNEAVMSTMGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BMW6</accession>
    <name>A0A9X0BMW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_008111</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ODC and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODC antizyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786803.1">
        <property type="nucleotide sequence ID" value="XM_056937711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BMW6"/>
    <dbReference type="GeneID" id="81627961"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279:SF10">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0688">Ribosomal frameshifting</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5475045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="271" mass="29487" checksum="7FBCF168CDE43ABA" modified="2023-11-08" version="1">MPRFLAQQSTVTASCYTVNSSSGNVYGFHYCSTLGAGMPEHSRDSFSEHSGIPEVPSGSKISTPRPPLEYAASSGALSWTGTNGPESHAKGEAAYTIPEECERLFCDTLATTFLGERIDVGQESLGMGTFQQTQASQHHRPASYYRQRPSHRSIEKWIEVWDYSGDAIYRGFVTGEGDERTLFVFLEDGTIGQGLKSGLIALFELAGSDAFDCTQIVACVNRSQHTDEMELVRSLGWCGFNLTTLDPWIQGTSGAAGPAVSTKWLFLVAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BN97</accession>
    <name>A0A9X0BN97_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">ABC multidrug transporter A-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_008385</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787077.1">
        <property type="nucleotide sequence ID" value="XM_056937985.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81628235"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
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        <location>
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            <end position="571"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
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            <end position="1212"/>
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            <begin position="1224"/>
            <end position="1247"/>
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            <end position="1294"/>
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            <end position="1335"/>
        </location>
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            <end position="1370"/>
        </location>
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        <location>
            <begin position="1463"/>
            <end position="1484"/>
        </location>
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            <begin position="156"/>
            <end position="411"/>
        </location>
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            <begin position="856"/>
            <end position="1098"/>
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            <end position="89"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5475319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1659" mass="186299" checksum="84E28470572E7381" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNJ6</accession>
    <name>A0A9X0BNJ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5476945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="63946" checksum="1B722CAFED7FE4EE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNU4</accession>
    <name>A0A9X0BNU4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_007874</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787340.1">
        <property type="nucleotide sequence ID" value="XM_056937475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNU4"/>
    <dbReference type="GeneID" id="81627724"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
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        <location>
            <begin position="74"/>
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        </location>
    </feature>
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        <location>
            <begin position="100"/>
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        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
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        <location>
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            <end position="211"/>
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        <location>
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        <location>
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            <dbReference type="RuleBase" id="RU003346"/>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAJ5475587.1"/>
        </source>
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        <source>
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    </evidence>
    <sequence length="519" mass="56694" checksum="5E233B3CE7C04F1F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BP35</accession>
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    </gene>
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        <name type="scientific">Penicillium diatomitis</name>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">IBT 30728</strain>
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    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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            </authorList>
            <dbReference type="PubMed" id="36726175"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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            <strain evidence="2">IBT 30728</strain>
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    </reference>
    <reference evidence="2" key="2">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAJ5481025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="131" mass="15019" checksum="D3ADBEE9314E962C" modified="2023-11-08" version="1">MKPYQHWPAAFVLMVTMISLMGLTALLGFFHWAAWTVYYCWRENFYGRAIVPDFIVISDEANGVLVTQSLKRFHFLPILTLAGTTALTCLETGIRTPVLFIDAVRRTHQRREIFGRWVHNSASVSTEQAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSG6</accession>
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        <recommendedName>
            <fullName evidence="2">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Penicillium diatomitis</name>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="81626813"/>
    <dbReference type="Proteomes" id="UP001148312">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22952">
        <property type="entry name" value="ART10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF166">
        <property type="entry name" value="ARRESTIN (OR S-ANTIGEN), N-TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02050)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5481069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="608" mass="66597" checksum="6DBB5E12FAE5AF7D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSM0</accession>
    <name>A0A9X0BSM0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">N7539_006997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="81626847"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="575"/>
        </location>
    </feature>
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        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
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        <location>
            <begin position="343"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="542"/>
        </location>
    </feature>
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        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="387"/>
        </location>
    </feature>
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        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
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        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5481103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="575" mass="55020" checksum="B023E1850953DDB2" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BT00</accession>
    <name>A0A9X0BT00_9EURO</name>
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        <recommendedName>
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        </recommendedName>
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        <name evidence="9" type="ORF">N7539_006382</name>
    </gene>
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        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788908.1">
        <property type="nucleotide sequence ID" value="XM_056935984.1"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="40S ribosomal protein S29"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_A">
        <property type="entry name" value="Ribosomal_uS14_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uS14_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_uS14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="RIbosomal_uS14_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_uS14_sf"/>
    </dbReference>
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        <property type="entry name" value="PRK05766.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
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    </dbReference>
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        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5482936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8759" checksum="99B7E261066DEAA0" modified="2023-11-08" version="1">MTHESVWYSRPRKYGKGSRECRVCTHRAGLIRKYGMNICRQCFREKSTDIGFNKVRFFFLLLILRPHHIPNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BT34</accession>
    <name>A0A9X0BT34_9EURO</name>
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        <recommendedName>
            <fullName evidence="2">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
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        </lineage>
    </organism>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789013.1">
        <property type="nucleotide sequence ID" value="XM_056936089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BT34"/>
    <dbReference type="GeneID" id="81626338"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR XBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="2">
        <location>
            <begin position="77"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5483041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="520" mass="58403" checksum="4E8F5C1262123931" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BT74</accession>
    <name>A0A9X0BT74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788907.1">
        <property type="nucleotide sequence ID" value="XM_056935983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BT74"/>
    <dbReference type="GeneID" id="81626232"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5482935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="111" mass="12168" checksum="449362D90931C4F3" modified="2023-11-08" version="1">MLMINAEPSKALGEKPDEIDQPLAAKSAAQRCARLAGPYVGHQHPAISYHSAAELTRYTKSTLHGRIFVQRSAFGVCTSVSLVNALQRSKYVMRLETRKGGKAERLLVGYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BTW2</accession>
    <name>A0A9X0BTW2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6 18">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">N7539_005823</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 18">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6 18"/>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789297.1">
        <property type="nucleotide sequence ID" value="XM_056935425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BTW2"/>
    <dbReference type="GeneID" id="81625674"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000023">
        <property type="entry name" value="3-isopropylmalate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000003">
        <property type="entry name" value="3-isopropylmalate dehydratase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012235">
        <property type="entry name" value="3-IsopropMal_deHydtase_ssu/lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002458">
        <property type="entry name" value="PRK01641.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004016">
        <property type="entry name" value="PRK05478.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009116">
        <property type="entry name" value="PRK12466.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF9">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001418">
        <property type="entry name" value="ACN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 18" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="20">
        <location>
            <begin position="13"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="21">
        <location>
            <begin position="534"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="745"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="761"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ5484027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="770" mass="83619" checksum="4309203718306D6D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BU15</accession>
    <name>A0A9X0BU15_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">High-affinity glucose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_004697</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789493.1">
        <property type="nucleotide sequence ID" value="XM_056934299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BU15"/>
    <dbReference type="GeneID" id="81624548"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="11"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5484709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="538" mass="58645" checksum="56CCB3B62E28AE78" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUB9</accession>
    <name>A0A9X0BUB9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_004997</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789793.1">
        <property type="nucleotide sequence ID" value="XM_056934599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUB9"/>
    <dbReference type="GeneID" id="81624848"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:secondary metabolite biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="8"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5485009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="425" mass="47422" checksum="AD13A0CF0ECD22EC" modified="2023-11-08" version="1" fragment="single">MGFSEKHIAVIGGGLGGMSFMNAALYTGLEHVQLYEQAPQFAEVGAGVNITSNANRVLDAFGLEEIIMRRSSRQLPSYMEYRQYKTGEYLAQINEFSRPPARLLHRAHLLDALKERVPSSKINLGKRLVSIECEAGALSAPYTLHFEDGSVANTDIVIGCDGIRSNVRQYMGFVDSPKYSGQVVYRGFVDYKDLPDETAQLLRRTVNFRGPKKHVLVLPIGNQETQTDRAAIIGFMTESLDSWESESWMSRSEISSFQEHVQDWCFQVQHIVAGLSSTAKGLQASSSWATLLIPHYHIKVSLEIPTSFTVSIGTDTGKRVKGQGTCMAIESGIALAMILRHWAGEDIEAAFQFYQDLRKPRTDRVTQTSQEAGKLASSDSPNGMTEGFSPEVLTDRMRWIMEYDILEELRLKGAGVLECSRFDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUM1</accession>
    <name>A0A9X0BUM1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-rRNA processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_004999</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789795.1">
        <property type="nucleotide sequence ID" value="XM_056934601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUM1"/>
    <dbReference type="GeneID" id="81624850"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059065">
        <property type="entry name" value="Ig_Tag1-like_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059066">
        <property type="entry name" value="Ig_Tag1-like_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055011">
        <property type="entry name" value="Tag1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF3">
        <property type="entry name" value="PRE-RRNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26174">
        <property type="entry name" value="LEA-2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26150">
        <property type="entry name" value="LEA-2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26153">
        <property type="entry name" value="LEA-2L_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22786">
        <property type="entry name" value="Tag1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1 C-terminal" evidence="3">
        <location>
            <begin position="467"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1-like fourth Ig-like" evidence="4">
        <location>
            <begin position="590"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1-like fifth Ig-like" evidence="5">
        <location>
            <begin position="755"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5485011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="870" mass="93613" checksum="5C53E7408BD7CDF6" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUQ8</accession>
    <name>A0A9X0BUQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_004878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789674.1">
        <property type="nucleotide sequence ID" value="XM_056934480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUQ8"/>
    <dbReference type="GeneID" id="81624729"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5484890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="346" mass="39850" checksum="C69AB8FC280D0327" modified="2023-11-08" version="1">MNPVSPLAAHVCSSRLEALPVEIIQAIFLHSLEINLPRASPYIARALSKPILYTWLIRLAFSSANASSQQGFFTPDFLPPPLDFWNVTWQCRQRLQTQILECRWCTWPLMRRCQREYVEHVLRRKCADLVFTDEAQLVLGSLDASFNDLEGADWAPRGYRGKGDLILPAYLPNEDAATPPTVNRKVAIWLHLGAVQIRFLNDVFYEDDLFQLPCGSALGAGQIPDKLLQEPWSEEQFQFLQLLSSDFYVDEDGANAERSSQITTRLIRKRRLDPFHRLLRMYFRTGNCRVPSRWPLQASHFALIQRCMEGPEDPFAQVVWNVRWDDIPTSARQELMLAMTARAEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUR6</accession>
    <name>A0A9X0BUR6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase II subunit RPB9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA-directed RNA polymerase II subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_005476</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790272.1">
        <property type="nucleotide sequence ID" value="XM_056935078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUR6"/>
    <dbReference type="GeneID" id="81625327"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034012">
        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040913606" description="DNA-directed RNA polymerase II subunit RPB9" evidence="13">
        <location>
            <begin position="22"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="14">
        <location>
            <begin position="175"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5485488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="215" mass="22576" checksum="FA70454F847D44F3" modified="2023-11-08" version="1" fragment="single">VTSSLCLTILISSSLIAIAIAIATMSASPVASGAADAKPTDQIHFRFCRECSNLLYPKEDRHTNQLMFTCRTCHVGEPATSHCVYQNKLNSQVGDTAGVTQDVASDPTVGTPELLFSSAMSLPGFCACCGDEITCDICGLGYFVIPEDDKATGPSCASGAPGSDLLVGSGTLPRANRLCPSCGENEAVFFQSQQRSAESGMKLYYVCCACGNVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BV15</accession>
    <name>A0A9X0BV15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_005163</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789959.1">
        <property type="nucleotide sequence ID" value="XM_056934765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BV15"/>
    <dbReference type="GeneID" id="81625014"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000012">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF69">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5485175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="397" mass="44173" checksum="B7848B1EA21C3D79" modified="2023-11-08" version="1">MGSIATNVAELDASKFNITRSTNLRDVPLPGSPEELSHSYCTDHMVTVRWTVNNGWETPEVKPYQNLSVPPTASCLHYATECFEGMKVYRGYDGKLRLFRPDLNGQRLNTSSQRSSLPGFKADEVKKLVAKLMEIDGPRWLPKDRPGSFLYIRPTVIGNGPHLGVQVPKEALLFIIAVPWPDFTKMKKEGETVSKGLKLFASSPDSIRAWPGGFGWAKLGANYGPSLQSHGKAQAMGFDQILWLFGEDRQVTEAGASNFFIIWHNADTGRLELVTAPLESQLILPGVTRRSVLELARERLSENFVGKLAPLQVVERTLTISEIEKAAQEGRIVESFVSGTAYFITPVAMIRNNDQDISTLGKDGEPAGYAAQIKSWLEAIMYGKEEHEWAYLVEEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BVH8</accession>
    <name>A0A9X0BVH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790469.1">
        <property type="nucleotide sequence ID" value="XM_056935275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BVH8"/>
    <dbReference type="GeneID" id="81625524"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="572" mass="62337" checksum="D05064476F9819EB" modified="2023-11-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY25</accession>
    <name>A0A9X0BY25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAM192A/Fyv6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_004245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791388.1">
        <property type="nucleotide sequence ID" value="XM_056933847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BY25"/>
    <dbReference type="GeneID" id="81624096"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5489355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="240" mass="26493" checksum="15A78796DF45F401" modified="2023-11-08" version="1">MSSGFVSAGTNEEPVERDDAWVRVQKELEEERRRKAEIGQQKDGKSLYEVLQQNKMAKQEEHEEKMRLKNQFRALDEDEVEFLDSVLESTRAQEEAVKKETADQLEAFRKQREEAEKAAMGHTSSEVTPAAAEEEDWAISSKKRRRDKGKDSLLPGKRRKSSAVDEVESPTPQSQKPQGKDKSSPAIAVAKKDTPARKPAEPAAPSTAGPGLPKKEPPKPSQASPPALGLVGYGSDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYA8</accession>
    <name>A0A9X0BYA8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_003902</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="81623753"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
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        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PTM1-like_N"/>
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    </dbReference>
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    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="20"/>
        </location>
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            <end position="531"/>
        </location>
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        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="237"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="278"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="309"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="11">
        <location>
            <begin position="31"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="183"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="457"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5489012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="59382" checksum="B2765A8823715068" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYB7</accession>
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        <recommendedName>
            <fullName evidence="13">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="14" type="ORF">N7539_004264</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
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        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="172"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <end position="205"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <end position="242"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="13">
        <location>
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            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="516"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5489374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="608" mass="67482" checksum="D4D48A5D36E03A0D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYC4</accession>
    <name>A0A9X0BYC4_9EURO</name>
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        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_004128</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791271.1">
        <property type="nucleotide sequence ID" value="XM_056933730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYC4"/>
    <dbReference type="GeneID" id="81623979"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="125"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="247"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5489238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="390" mass="42389" checksum="DAFD2D4B34A62EBD" modified="2023-11-08" version="1">MGSLANGSQQGTFLFTSESVGEGHPDKIADQVSDAILDACLAEDPLSKVACETATKTGMIMVFGEITTKARLDYQKVIRDAIKDIGYDASEKGFDYKTCNVLVAIEQQSPDIAQGLHYDEALEKLGAGDQGIMFGYATDETPELLPLTILLSHKLNSAMKAARNDGSIPWLLPDTKTQVTIEYAHDNGGVKPLRVDTVVISAQHTEDVSTEELRTVLKEKIVRKVIPAHLLDDRTVYHMQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYSKVDRSAAYVARWIAKSLVTAGLARRALVQLSYAIGVAEPLSIFVETYGTSPKSSDELVQIIRNNFDLRPGVIVKELDLAKPIYIQTAKNGHFTNQSFSWEKPKALKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYH7</accession>
    <name>A0A9X0BYH7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Demethyl-4-deoxygadusol synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002272</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791834.1">
        <property type="nucleotide sequence ID" value="XM_056931875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYH7"/>
    <dbReference type="GeneID" id="81622124"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08199">
        <property type="entry name" value="EEVS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000015">
        <property type="entry name" value="3-dehydroquinate synthase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000018">
        <property type="entry name" value="Related to 2-epi-5-epi-valiolone synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050071">
        <property type="entry name" value="Dehydroquinate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035872">
        <property type="entry name" value="EEVS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622:SF3">
        <property type="entry name" value="2-EPI-5-EPI-VALIOLONE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622">
        <property type="entry name" value="3-DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dehydroquinate synthase N-terminal" evidence="6">
        <location>
            <begin position="85"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="3-dehydroquinate synthase C-terminal" evidence="7">
        <location>
            <begin position="195"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5490705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="466" mass="51575" checksum="34817724D1D8BEAA" modified="2023-11-08" version="1">MSDLKATVVETTSGFHVEGYEKIEYDFTFLDGVFETQNRQLAQLYERWGRCLAIMDKNIFDIYGSKMQEYFKYHNVELKIHQTMIGEKAKSLETFTQIVDSMTDFGIIRKEPVLVVGGGLVTDVAGFACAAYRRNTNYIRIPTTVIGLIDASVSIKVAVNYGNYKNRLGAYHAPMHTILDFGFLRTLPEAQVRNGFAELIKISSCAHLPTFNLLDKYCEQLISTKFGRAGDNAEVKQAADEINRNGIFEMLKLETPNLHEIGLDRVIAYGHTWSPLHELTPPTPLRHGHAISIDMAYSATLANTRGLLSDEEHRRILKLFSRCGLSMDHELFNEEILAKATAAILKTRDGLLRAAVPSPLGSCKFLNDVTDEEMAAALRRHKALMQEYPRNGAGIEAYVDASDTGYTVNAAVEEPTKEVEANGQKPTDPVVAGAKDGVLRTGLTSELKDLAANGHANGLPTVQAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYI7</accession>
    <name>A0A9X0BYI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_004127</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791270.1">
        <property type="nucleotide sequence ID" value="XM_056933729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYI7"/>
    <dbReference type="GeneID" id="81623978"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="38"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="12">
        <location>
            <begin position="454"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="551"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="594"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5489237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="624" mass="68044" checksum="1D7491832ABFDDC8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ19</accession>
    <name>A0A9X0BZ19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">N7539_002887</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792449.1">
        <property type="nucleotide sequence ID" value="XM_056932490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ19"/>
    <dbReference type="GeneID" id="81622739"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18 20" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAJ5491320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="374" mass="43026" checksum="16BE028729BB5BD8" modified="2023-11-08" version="1">MPGQTLPTFTPVQVESHNNAKSCYITIGRNVYDVTDFVEDHPGGGDLILEYAGKDVREIMKDEISHEHSEAAYEILTDYHVGFVSSVAVGKSEATSQDREGAPGQPVYASTGMSREEDLSVDTDYTQDYKTYKFLDLNKPLFAQLWYGDFSKDFYLEQIHRPRHYKGGDSAPLFGNFLEPLSKTAWYVVPLIWLPCVFYGTVVASKGLGDATPAAAYWAGGVFIWTLVEYLLHRFLFHLDKWLPDNRVGLTLHFLLHGIHHYLPMDRYRLVMPPTLFLILAWPFWKLAHAVFFYNWFAATQVFCGGVFGYVCYDLTHYFIHHRNLPMHYKELKKYHLAHHYADYENGFGVTSRFWDKIFGTELETSVPKGVKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZY0</accession>
    <name>A0A9X0BZY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792795.1">
        <property type="nucleotide sequence ID" value="XM_056932836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZY0"/>
    <dbReference type="GeneID" id="81623085"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="85" mass="9652" checksum="3932AB526F2CE98E" modified="2023-11-08" version="1">MMELMQNYAKEGIVGIANPDRWEICPAAIEFVSATISASSFEELKKHCFLTETRWCLGDLIGLIWFALISARTFYLYTPRSEAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C002</accession>
    <name>A0A9X0C002_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_001356</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792990.1">
        <property type="nucleotide sequence ID" value="XM_056930959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C002"/>
    <dbReference type="GeneID" id="81621208"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="4">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5492610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="191" mass="22414" checksum="D08EF33872107C28" modified="2023-11-08" version="1">MRVETCHFCSRPAFPGKGITFVRNDARQFRFCRSKCHKNFKMKRQPRKLKWTKSHRAARGKEMIVDSSLVLSQFAKKRNVPVKYDRNLVAATIHAMQRVEEIRQRRERVFTKRRLAGKIARDRQREADRKVVAEGEHLIRKELREREEGRPMVAEQSKVANRVHGADLFAQKKKTKVLVDGGVEEEAMDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C014</accession>
    <name>A0A9X0C014_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Caffeine resistance protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_001818</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793452.1">
        <property type="nucleotide sequence ID" value="XM_056931421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C014"/>
    <dbReference type="GeneID" id="81621670"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="504"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="550"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="164"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5493072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="609" mass="67529" checksum="F97401F3E37BB32A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0F2</accession>
    <name>A0A9X0C0F2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PrpF protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793636.1">
        <property type="nucleotide sequence ID" value="XM_056931605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0F2"/>
    <dbReference type="GeneID" id="81621854"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="ACONITATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709:SF2">
        <property type="entry name" value="DUF453 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5493256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="42361" checksum="4BE46CFA64ACF154" modified="2023-11-08" version="1">MRTSLRELRTPITGRRSLRTKQNALPAAYYRGGTSRAVFFKEEHLPHDRREWSSIFRGVIGSPDPYGRQLDGLGGGISSLSKICVVGKSTHPDADVDYTFVSLGIKDKDVDYSSNCGNMISAVGPFAVDSELIPVPLSEVGETDETVLVRIHNTNTGKIIHSHFPVVDGEAATTGDFSIDGVAGTSARIRLDFINPAGSVTGMLLPTGSVTDKIDGAIVTCLDAGNPCVFADAAALGVNSDLSPQEIATHPTLLPRLDTIRRQSGVKMGIASTVDNVPGSIPKICLVGKPTSAGARDSQLGQDGGQVDILARALSVGQPHKAVPITVALALAAAARVPGSVVADIVGDQRRVDDAGLIIGHASGNLLVGANFDEKGCLTSATVFRTARRLFQGTVFWKNESSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C1T8</accession>
    <name>A0A9X0C1T8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily multidrug transporter NAG3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_000018</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793915.1">
        <property type="nucleotide sequence ID" value="XM_056929622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C1T8"/>
    <dbReference type="GeneID" id="81619871"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF48">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="95"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5494902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="542" mass="59897" checksum="6B0AFA4465C94FDC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2E2</accession>
    <name>A0A9X0C2E2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_000502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794399.1">
        <property type="nucleotide sequence ID" value="XM_056930106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2E2"/>
    <dbReference type="GeneID" id="81620355"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5495386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="124" mass="13743" checksum="5EDBAD17F40D86DD" modified="2023-11-08" version="1">MSRADRCFNFTDALPDTGPYQPGWCGVAISQQIMKNNNTPYQALTQCCTSGQYTLWPETYNRNYPEKCFAYCKTFNQTQLQQVGRCLDANVGSHGCASGGPHAVMLSWSTLLLSVLLMSVMLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2M3</accession>
    <name>A0A9X0C2M3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RTA1 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_000873</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794770.1">
        <property type="nucleotide sequence ID" value="XM_056930477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2M3"/>
    <dbReference type="GeneID" id="81620726"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF13">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="329"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5495757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="40959" checksum="032493B5C70E3C3C" modified="2023-11-08" version="1">MSDTVISYYRYDPSHVAPAVFAGVVGLSLVVHIWQNFHYRFWRVTFWLFLGSLVFTIGWILRCISSFQTGNKGLYIAQTIFIYLAPPIYSAAAYNMVGRLMNYLPMHAVFHPDRVLIVFVYLGVIVETVTAAGAARLAAAQSNLKLFKSGGDLITTGLILQIVVESMVILTVAIIHRRVAKTRHTPRNVKIVCRTLYGTSFFVLLRCIFRTVEAFDRFGNIDCTNNCSPIVSNEWYLFAFELGPMLIFTYWLNILHPGQYLPRDKTRYLDLDGHTERMGPGWTDRRSRWATFADPLDFEGKIKGHVSHDEFWLRPGEWPVCEDGSFVDGTASNSKAPPRSMKRAKKRAKGTEVHSVSTVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C370</accession>
    <name>A0A9X0C370_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_000935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794832.1">
        <property type="nucleotide sequence ID" value="XM_056930539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C370"/>
    <dbReference type="GeneID" id="81620788"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000013">
        <property type="entry name" value="Proteasome regulatory particle subunit (RpnG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000021">
        <property type="entry name" value="Putative proteasome regulatory particle subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="240"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5495819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="504" mass="55832" checksum="581CB3F631A4DBD2" modified="2023-11-08" version="1">MGSDPQFIKYPDLLLAQSVFNLSNPACNASTRQASLKKLQDAITERKMAPFYRHLAHPTEGILNTSGEGVTQHPHPHNAGASKPLITSNMLASRPSSDIEFPWDEKLYQTLVEDNKKELEGIQNEEDEAEEAAGETEVQAARGKRAEFWARVGDKSADPVDPTQDKSIESHEALLDKIGFLGTKIDLVLAMIRIGLFFGDRLYVKKTIERAEALVESGGDWDRRNRLKAYKGMHLLTCRSYNLAAPLLLDSLSTFTSYELCSYSSLVIYSVLAGSLSLKRVDFKAKVVDAPEIKAILGAGEDQLAALSGEVSSGPGALDEEMIDATVSKSTPTTGAKTVVNLTTLVTGTTDQAENEAPVDFSSLANLVNSLYNGNYRSFFNALAAVEDHFLTQDRYLQEHRAWFVREMRLRAYQQLLQSYRVVGLTSMANDFGVTVDYLDRDLAKFISSNRISCTIDRVNGIIETNRPDDKNKQYSDVVKHGDSLITKLQKYGQAVRLRGSERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C3F1</accession>
    <name>A0A9X0C3F1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dynactin subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_001175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795072.1">
        <property type="nucleotide sequence ID" value="XM_056930779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C3F1"/>
    <dbReference type="GeneID" id="81621028"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15346">
        <property type="entry name" value="DYNACTIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5496059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="55195" checksum="ECB62DC0F66A8887" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C3F5</accession>
    <name>A0A9X0C3F5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Formamidopyrimidine-DNA glycosylase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_001251</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795148.1">
        <property type="nucleotide sequence ID" value="XM_056930855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C3F5"/>
    <dbReference type="GeneID" id="81621104"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08972">
        <property type="entry name" value="PF_Nei_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000009">
        <property type="entry name" value="Formamidopyrimidine-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="H2TH_FPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993:SF9">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="N-terminal domain of MutM-like DNA repair proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formamidopyrimidine-DNA glycosylase catalytic" evidence="11">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="294"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5496135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="375" mass="42179" checksum="E0835FCAF7A790B8" modified="2023-11-08" version="1">MPELAEVGRIVHFIRQHLVGKTLSKVQANHDEIIYGKVGTSAAEFQKAMQGKKVTGAGQQGKYFWMTMSTPPHAVMHFGMAGWMKIKDQDTYYYRSDKPGDQEWPPKYAKFILETSEDPQTEAAFVDPRRLSRIRLVDCPAEEIRNHTPLKENGPDPVADKDIVNEAWLRDKLRAKKVPVKALLLDQANISGIGNWLGDEILYHAKIHPEQYSNTLSDEQIKELHNSLHYVCSTAMDALADSEKFPEHWLFKHRWGKGKKDHPKALPNGDKITFITVGGRTSAVVLAVQKKSGAVATDNGDGGESAKPKRKKPVKEEEEEDETSDVDEKPAPKVLKSKGRGRSSIKNEAKDEDAVKEELPQDTSPPRRRSTRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKG6</accession>
    <name>A0A9W9WKG6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_009396</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785713.1">
        <property type="nucleotide sequence ID" value="XM_056938991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKG6"/>
    <dbReference type="GeneID" id="81629241"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF163">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_8G05510)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="47"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="313"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5466667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="390" mass="44835" checksum="543420E54013D235" modified="2023-11-08" version="1">MDDLLSTPIVAVLGPPPASVNLEDNRTWKDNAIVVAISAVAVLSVAVRFIVRFRSHNARPFMDEWLAAVSLVPMLALLASALVAGHHGLGKHVWLLEIGVMVKLKKILFSYLFIYLFELFLIKLCILSFYRRIFGRRTTIWICLLLTVCWTLGSMIALLTSCAPVSYFWTSTYDLHSGHFRYDFYDYYIGNAATNVLIDLLILLIPIPVVWKLKMRITQKLMITGVFFIGVFVCVASIVRLHYLTYLKNTVDITWYMSDVYVWSTVEPCLGIICACLPALQPLVRSFMKAEHMLYLRNRVRHSKQVKQFRTRISNNSSKSFSRSRSQTSDSLEDKPELGFRSNDDEVHLTSCVAQAESERCRRERENLEEFLGPMFIRVEHEVEWTVDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WM83</accession>
    <name>A0A9W9WM83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_009331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786303.1">
        <property type="nucleotide sequence ID" value="XM_056938926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WM83"/>
    <dbReference type="GeneID" id="81629176"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5469713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="295" mass="33459" checksum="AE8A32E9BA5F61B4" modified="2023-11-08" version="1" fragment="single">DALNNDFSLNKAADKLHCHGFSFGGDDLRFNRITYRHSRIFLRSTKNILIFYTPPPGVPNTLYPSCPGLEQRDSTAYQTFRTFLISPTRHLDLVIPSPTERSNQIPSPYHDISSTKFNEYLVLLPLRVSISSQFQDKTSINPKLISSLDGQTGGSEEIESEKEVQYLAAIAVEQTQTLRLTEKESDLDDFNVSIRSYILLTARQATVKDRAERENFLEELQRRVVQVSIIQSERVQICVAGVLNIMESYSREWQGRWAGSEDESTLLRRILLDNSQLNSLPSGTVHGFPRSSTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQU4</accession>
    <name>A0A9W9WQU4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <end position="47"/>
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        <location>
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            <end position="147"/>
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            <begin position="105"/>
            <end position="114"/>
        </location>
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            <end position="137"/>
        </location>
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        <location>
            <begin position="138"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAJ5472000.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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</entry>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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            </authorList>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAPWDQ010000013">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5472077.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WRD0</accession>
    <name>A0A9W9WRD0_9EURO</name>
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        <recommendedName>
            <fullName evidence="3">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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        <location>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WRG5</accession>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Nielsen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786509.1">
        <property type="nucleotide sequence ID" value="XM_056938127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WRG5"/>
    <dbReference type="GeneID" id="81628377"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5471963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="59" mass="6378" checksum="2FDB7563625B4B43" modified="2023-11-08" version="1">MAPGSLRSYGTIIRQLRAIGSDEYSSVALYSGPHGLGRNVDDYGYVLLVAINPGTWYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTV4</accession>
    <name>A0A9W9WTV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786906.1">
        <property type="nucleotide sequence ID" value="XM_056937814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTV4"/>
    <dbReference type="GeneID" id="81628064"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="107"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5475148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="241" mass="27640" checksum="63F3AFEED6C21751" modified="2023-11-08" version="1">MASDTRVTLIPWDPQSPSHRAWLLQQRDECGWDREKVNGVWIDYQTQGIKSIFWIVLPEDKQDSAYDETQQSFEEDQQSSDTQPLFLRDTAQSLKGVSRQPTHVKFQPVGHISLDSDNPGVERVGVTSSAPGMFWIKTFFVSKTVQSRGVGRAAMEELELMATSAPLSARVLVLDVVLGEDQMREDFALATYGTLPKFSTEQWYLRRGYSPFQTAQNFYDVVDRSGKRWDMRTVFMKKEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUJ5</accession>
    <name>A0A9W9WUJ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_007893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787359.1">
        <property type="nucleotide sequence ID" value="XM_056937494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUJ5"/>
    <dbReference type="GeneID" id="81627743"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5475606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="100" mass="11647" checksum="29DC5F06BAE4F4AD" modified="2023-11-08" version="1">MQLLDQFLQLRYELIGSLTAWVNGTYFIPPEAMASILDRHIQDIAHYQGLGDSYFYLKCNKVRQILLFASHELQVRRTLTRDVCRAMNEAVVCLRQLQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUL0</accession>
    <name>A0A9W9WUL0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Histone H2A.Z-specific chaperone chz1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_007127</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a heterotrimer with H2A.Z-H2B, stabilizing the association of the histone dimer. Also, with a lower affinity, forms a heterotrimer with H2A-H2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHZ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5476983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787527.1">
        <property type="nucleotide sequence ID" value="XM_056936728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUL0"/>
    <dbReference type="GeneID" id="81626977"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019098">
        <property type="entry name" value="Histone_chaperone_domain_CHZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09649">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01082">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone" evidence="8">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5476983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="108" mass="11951" checksum="0289DC4AF6376F70" modified="2023-11-08" version="1">MGDHATTNNPSSSTTEAALADKGKGKAQDPDMSMEDDSDSESDNGEEMEEANDDLEPISETNIINGGRRTRGKKIDWEEVRKTSDDMDDEEDDDEDYQGGADEDQMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV12</accession>
    <name>A0A9W9WV12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">glucan endo-1,6-beta-glucosidase</fullName>
            <ecNumber evidence="8">3.2.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_007884</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Random hydrolysis of (1-&gt;6)-linkages in (1-&gt;6)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.75"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.75" evidence="8"/>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787350.1">
        <property type="nucleotide sequence ID" value="XM_056937485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV12"/>
    <dbReference type="GeneID" id="81627734"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000128">
        <property type="entry name" value="Endo-1,6-beta-D-glucanase neg1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040996416" description="glucan endo-1,6-beta-glucosidase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="11">
        <location>
            <begin position="74"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="12">
        <location>
            <begin position="429"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5475597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="487" mass="51562" checksum="C953286405B562FF" modified="2023-11-08" version="1">MVYAAWALLSLATLSHGYATEKRAGSASAFSSNSAGNYKLSSIAAPVQGSGNPGSESTWKLSIDDTSSGHKQSITGFGAAVTDATVTTFNRLSSSNLQSLLEELMTNSGADFSLMRHTIGASDLSGDPAYTYDDNGGSADPSLSGFNLGDRGTAMAKMLARMKSLQSNLKILGSPWSAPGWMKLNGVIDGTTNQNNLNDGYLSSGTGSSGYAQAFANYFVKYIKAYQNLGANIDAITIQNEPLNSQSGYPTMYVYADESAQLIQKYVGPAISQAGLNTNVWAYDHNTDVPSYPQTVLDNAGQYVNSVAWHCYAPNNDWGVLTQFHNSNPSVSQYMTECWTPAGTWNQAADFTMGPLQNWAQGVIAWTLATDGSDGPHLSSGGCGNCQGLVTINGDSYSFNPAYYMMAQFSKFMPPGAIVLDGTGSYTYSGGGGVQSVASLNPDGTRSVVIENTFNNDVYVTLSTKSGQQWSGNIPSESVTTWVLPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV26</accession>
    <name>A0A9W9WV26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787823.1">
        <property type="nucleotide sequence ID" value="XM_056937024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV26"/>
    <dbReference type="GeneID" id="81627273"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099122">
        <property type="term" value="F:RNA polymerase II C-terminal domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF618 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047883">
        <property type="entry name" value="Rtt103-like_CID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF0">
        <property type="entry name" value="CID DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5477279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="409" mass="44795" checksum="8FB212514943826A" modified="2023-11-08" version="1">MAYTDDAVKAKLSALNETQESIVTVAQWVMFHRRHAEKTAQIWLERIRDSAPPKRLNLVYLANEVAQQSKVRGKEDFLIAFSPIVAEATAAAYKGASNDIQNKIRRVVEVWRQRHVFEGPILDAVEARINDIEKNRPTTKKQTLGGSFFKGSSDSTPSELQPLVPLQVALTKAAMTSNSSATTATTEYDKLNDPNAPSITPPVHAARLGTLLKALAHAENSVSAVIKSRRALIEGLEKLLENNRSELQKEESLVAEFSLRKAETDAKRREVEDAIMRGYQDELSAARQGNSSEEPSRPQVEALTPPPVEALTPVGSPAHQEQPVGHGPFTEEAPIDNAQAFTLQSIDQNDGSMPFDASSISPNGENDFDLGAHGTHAKRRKVAHDEDNEPFAEGVEDDVAAMIAQEANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVF9</accession>
    <name>A0A9W9WVF9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_007531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787931.1">
        <property type="nucleotide sequence ID" value="XM_056937132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVF9"/>
    <dbReference type="GeneID" id="81627381"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401:SF1">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5477387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16589" checksum="BCDDFE3C84AF6DB0" modified="2023-11-08" version="1">MSYQIAFEPSQAPAQGSTIVSFMEDFYRTSDTESLHAKYVESFTNDATLIMGSKEAKGSEEILRLRHGLWTHVASRRHTPERIFFSGNNSIMLHGGVTYRLKADPETDVYIPWAGRVEFAPFEDGEPVKMQFYQVYLDPSAQSGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1V1</accession>
    <name>A0A9W9X1V1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788130.1">
        <property type="nucleotide sequence ID" value="XM_056936195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1V1"/>
    <dbReference type="GeneID" id="81626444"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09615">
        <property type="entry name" value="Jacalin_EEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF1">
        <property type="entry name" value="SPHINGOMYELINASE DDB_G0288017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00915">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040774611" description="Jacalin-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Jacalin-type lectin" evidence="2">
        <location>
            <begin position="337"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5480700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="467" mass="50326" checksum="73944662B0D37E64" modified="2023-11-08" version="1">MKSTLALAAMFTASAHAAATSGKFTALSFNVAGLPELLQGNEVNGSKTENSGLIGTYFAKYGYDLIHLQEVSPAAGEGVWFVVDQDANRGVLDKDFNYHAYIYATDNHQYRTPTSGGAAIGSGLNSLSNYSWLNFLRTKWNKCSSASGSDCLTPKGFTFMRWNPSEGVYIDVYNFHADAGTEPDDEQARNSNLQQVADYIDTWSVGNAVLVMGDTNSRYTRQDDTGIRVFKSQNNLQDAWIVNAKGGVYPTAGADALLCVNPSTTETCETVDKVLYRGSSLVSLSSTSFLYAGEQFPNTNPEYLGQIISDHNPVLVDFSWTTSSDFRQSPFSGGPHGNWFNDLPKLPASPVASVLKFSGADRLDSVSIQLADGTTFSHGGTGGTAKSLTLGKGERWISTKLCTGQKDGRTRNFYIKATTSDGRTLEVGTATDSCTSFVADSGYGVVGFMGQDGDEIDQLALIYARYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X221</accession>
    <name>A0A9W9X221_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_006902</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788438.1">
        <property type="nucleotide sequence ID" value="XM_056936503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X221"/>
    <dbReference type="GeneID" id="81626752"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5481008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="37269" checksum="4B8A0C42B4148DC1" modified="2023-11-08" version="1">MAQPPGYHHTNPFTNDDQSIPPPSYDAATSSAPRGPPAPTTIPPQSFQHSASAPSDPPPYHNWQEAVPDTSVFPPPPISGYYSSGTGNASSDDAQRAHDFCDHTPLWLPVVPSNPVYQAVAQHDLRPVQQREYAGQLTHTAPGYWFGRTADRNGDCCVLTHLPLYFAAQDSPFLTEKAKTIYFEIKLFALRAGPGGDASGLSLGFAAQPYPSWRSPGWERGSLGVFSDDGCRFVNDSWGGRDFTAPFRVGETLGIGMTLSLPKDPLAMADAMFGTKRKCVVEVFFTRDGRPAGGWNLHEEVDADAGGVEGLEGDFDLYGAIGLFGGVDFQACFDPAGWRWRPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X287</accession>
    <name>A0A9W9X287_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Apoptosis-inducing factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_006943</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788479.1">
        <property type="nucleotide sequence ID" value="XM_056936544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X287"/>
    <dbReference type="GeneID" id="81626793"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03478">
        <property type="entry name" value="Rieske_AIFL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF2">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="10">
        <location>
            <begin position="13"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5481049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="550" mass="58431" checksum="B4F5E690AE2D5DA9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2B2</accession>
    <name>A0A9W9X2B2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_007037</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788573.1">
        <property type="nucleotide sequence ID" value="XM_056936638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2B2"/>
    <dbReference type="GeneID" id="81626887"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16456">
        <property type="entry name" value="RING-H2_APC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="35"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5481143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="96" mass="11201" checksum="723DF543761B39D7" modified="2023-11-08" version="1">MKVILKEWNAVATWHWDMPEDEVCGICRVQFDGTCPTCKFPGDDCALRELHTVNLLIGKCGHSFHMHCLMTWIQQETSKGLCPMCRQKFEWVQDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2C1</accession>
    <name>A0A9W9X2C1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_006686</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788222.1">
        <property type="nucleotide sequence ID" value="XM_056936287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2C1"/>
    <dbReference type="GeneID" id="81626536"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5480792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="263" mass="28653" checksum="9009CDBCF96005EC" modified="2023-11-08" version="1">MATFMLASNPDNVLHTSANGPLPAQSIDPAELPWLSSLTPPYEDSSDQQHESKFFQKPSYQQAEATQSGNPDAAPSQPPPQAQRTRRTRRLSSLSSSTETISPERAKHLERNRISANKCRLKKKKEHSRMESILNFETRKRDALLSEVGLLKDKLWCLKNMIFEHAQCDNPHINYQLARMTEQVLSKSPASAASISPVFATKSQPDGSAFFAGGGERRPLDSFGAAAAGTAGTAGTAGAALSSDMNLVQGYSETMFENLVDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3D5</accession>
    <name>A0A9W9X3D5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chaperone/heat shock protein Hsp12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788872.1">
        <property type="nucleotide sequence ID" value="XM_056935948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X3D5"/>
    <dbReference type="GeneID" id="81626197"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007250">
        <property type="entry name" value="HSP9_HSP12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04119">
        <property type="entry name" value="HSP9_HSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5482900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9555" checksum="07D6514968228421" modified="2023-11-08" version="1">MSDAGRKDFSTKAKEEITPDSAKSTQEKIKETVTDTTDRITRGAQPDDSKSTTQETFDKTQRVHDNKAHDGATGSVGDKIKSALGIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X4V3</accession>
    <name>A0A9W9X4V3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor CWC22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pre-mRNA-splicing factor cwc22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_005768</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789242.1">
        <property type="nucleotide sequence ID" value="XM_056935370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X4V3"/>
    <dbReference type="GeneID" id="81625619"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="FunFam" id="1.25.40.180:FF:000004">
        <property type="entry name" value="pre-mRNA-splicing factor CWC22 homolog"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MI" evidence="11">
        <location>
            <begin position="428"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="387"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="624"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="666"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="698"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="710"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="732"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="764"/>
            <end position="791"/>
        </location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5483972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="851" mass="97622" checksum="6CD96AD2F6D69EE2" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5B4</accession>
    <name>A0A9W9X5B4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789170.1">
        <property type="nucleotide sequence ID" value="XM_056935298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5B4"/>
    <dbReference type="GeneID" id="81625547"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058155">
        <property type="entry name" value="Skg3/CAF120-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25381">
        <property type="entry name" value="PH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="98"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="872"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="976"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5483900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1179" mass="130966" checksum="B3877E5887727B7E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5M6</accession>
    <name>A0A9W9X5M6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">N7539_005861</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="17">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="5 18"/>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789335.1">
        <property type="nucleotide sequence ID" value="XM_056935463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5M6"/>
    <dbReference type="GeneID" id="81625712"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000009">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12 18" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="11 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 16 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18 22" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="20">
        <location>
            <begin position="7"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="21">
        <location>
            <begin position="215"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="14">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="27"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="76"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="191"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="346"/>
            <end position="347"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="351"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ5484065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="383" mass="43346" checksum="6A3CFF7EE8FE3884" modified="2023-11-08" version="1">MANVLDDISHRRYNPLRGSHILVSPHRTKRPWQGQQESPSKTTLPSHDPECYLCPGNKRAQGDVNPKYESTFVFVNDYSAVKEEQAAYEGASGDDLEARFLNAEPVTGKCYVLTFSSAHNLTLADLSPTEIVPVINAWTEIYTAHLSPKSPLAVNAPPTHVQPSGHSASVTKPKEQYRYMQIFENKGAAMGCSNPHPHGQVWTTSTLPEEPAAELEQLRRYRQEHNGSHMLEDYAALESRKQERVVFENESFIVVCPWWATWPFETMIVSRTHKRALVDLSDADKVLLAEAIAEITRRYDNLFETHFPYSMGIHQAPLDGTDEEVEASYLHLHFYPPLLRSATVRKFLVGYELMAEPQRDITPEQAAARLRGCGGELYRKKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6C6</accession>
    <name>A0A9W9X6C6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_005095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789891.1">
        <property type="nucleotide sequence ID" value="XM_056934697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6C6"/>
    <dbReference type="GeneID" id="81624946"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000013">
        <property type="entry name" value="Putative Arf GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="9"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="279"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="354"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5485107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="479" mass="51039" checksum="A1494E26CDDFBA18" modified="2023-11-08" version="1">MSASKAQSQKIFEKLKLKPANKICFDCGSKNPTWSSVPFGIYLCLDCSAHHRNLGVHISFVRSTNLDQWQWEQLRVMKVGGNESATKYFQTHGGSAALSSKDPKTKYTSNAAVKYKEELKRRAALDQQQYPGEVVITDIPAGTPSDGSATPAGDQDDDFFSSWDKPSIKRPSNPPSRTGTPPVVSRNGSPFLNAGTGANGARSKSPLSASEEKVASPAPTAIRANSAARKTTPGTAAKKGSILGAKKAPKLGAKKVVASEIDFDEMERKAKEEAERIEKLGYDPEAEQAEAKAAATPAITAPTPISPTRGGFGATSKSSQERNSGDVERLGMGMSKLGFGQVSKPAAPKKLGFGAVGPAKSNMDEEELAEAKNRFGTQKGISSDEFFGRDRFDPKAQAEAKQRLGEFDGATSISSNAYFGRPEDDLPAGDDGYGDLENAAKDFVRRFGITAGDDLENLTQLVGEGATKLQGAIRSYLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6J4</accession>
    <name>A0A9W9X6J4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-dependent helicase hrq1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_005205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790001.1">
        <property type="nucleotide sequence ID" value="XM_056934807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6J4"/>
    <dbReference type="GeneID" id="81625056"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17923">
        <property type="entry name" value="DEXHc_Hrq1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18797">
        <property type="entry name" value="SF2_C_Hrq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055227">
        <property type="entry name" value="HRQ1_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957:SF3">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="MZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22982">
        <property type="entry name" value="WHD_HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="382"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="605"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5485217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1172" mass="131213" checksum="D4A214948DEB50E7" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6S4</accession>
    <name>A0A9W9X6S4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_005378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790174.1">
        <property type="nucleotide sequence ID" value="XM_056934980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6S4"/>
    <dbReference type="GeneID" id="81625229"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF4">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5485390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="275" mass="30306" checksum="1BBB0B1B032F2326" modified="2023-11-08" version="1">MQLKILTSLAVGQAGILHHITTSLIAFEHTHGSPRKPHTLLFIGGLGDGLGTVEYLEDVVAVEYIRKYKEPHYGPGKVVLMGHSTGSQDVMHYLYSPKPRPAHPVLDKCWEPVLRTPVDGAIMQAPVSDREAILWVVKCGTARDSPASMRELYKKAVFDAERNTYEENESVDTIVPLSVTSRIGYPANAPVSSRRFLSLVSPKSPAEPSEDDLFSSDLTDARLSETFGSIGSRGLLGQKMMVLYSGRDQSVPDWVDKEVLLDRWEKASNGCGRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X719</accession>
    <name>A0A9W9X719_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_005259</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790055.1">
        <property type="nucleotide sequence ID" value="XM_056934861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X719"/>
    <dbReference type="GeneID" id="81625110"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5485271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="209" mass="22448" checksum="2EB6E62FF2CA2DC4" modified="2023-11-08" version="1">MAAPLDRTTPTTTAYVVATAIVAGVTGYFLGQGASLGLFREKQGWPNGYDVKVHKDSSDEELEGQDSEEEEGDDDEDEGTGEELASFKDNEEEVKLVLVVRTDLGMTKGKIAAQASHATLACYKYFITHKPDSPILRRWEQGGQAKIALQIKSEDDLLLLQAQAMSLGLCARVIQDAGRTQIASGSRTVLGVLGPKSVVDGVTGHLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X733</accession>
    <name>A0A9W9X733_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056934926.1"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LD21067P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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        </location>
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            <begin position="365"/>
            <end position="423"/>
        </location>
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        <location>
            <begin position="437"/>
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        </location>
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        <location>
            <begin position="725"/>
            <end position="750"/>
        </location>
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        <location>
            <begin position="849"/>
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        </location>
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        <location>
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            <begin position="56"/>
            <end position="72"/>
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        </location>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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                <person name="Nielsen K.L."/>
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    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5485485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="141" mass="15565" checksum="0D3C4F00C1304F3C" modified="2023-11-08" version="1">MSCCMQKLSLSAAAHPLQTFPTNVTLAAEWSYPSCQRSWGSGPSPRAASHSVRSPSHLVAPAFSTHASQLVKARMEAAHESELGREPSLNALTMTFESLGIGKNMQRLVILIASVTAALELFIWCEYVWNWWGRDDSMIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XBT3</accession>
    <name>A0A9W9XBT3_9EURO</name>
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        <recommendedName>
            <fullName evidence="7">Replication protein A C-terminal domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Penicillium diatomitis</name>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="entry name" value="Possible replication factor-a protein"/>
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    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
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        <property type="entry name" value="NA-bd_OB-fold"/>
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        <property type="entry name" value="RFA2-like"/>
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        <property type="entry name" value="Rfa2/RPA32"/>
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        <property type="entry name" value="RPA_C"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A C-terminal" evidence="7">
        <location>
            <begin position="175"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5488499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="283" mass="29460" checksum="6C606A7AFE3F7844" modified="2023-11-08" version="1">MDGGYNNYNSYGGGGGGGGGGFMPGEMNSPSGGKGGDRDNKTLRPVTVKQIVDASQPFPEANYQIDGADVASVLLIGQVRNISTQSTNVTYKIDDGTGEIEVKKWIDSGSADSMDTDEGKGPGSGKNAIQLNGYARISGAVKSFGNKRYVGAHNVLPVTDINELHCHILEATVVHLFFTRGPPGGANAGAKNASAAGGDAMMGGAEDYGAGQNRALMSMSPLAKRVYQVLRTEPQDDTGLHVQQIAAKMNVPATDVARAGEELLGAGVIFSTSDEQTWAILEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XBY0</accession>
    <name>A0A9W9XBY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitotic checkpoint protein BUB3.2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_003455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790598.1">
        <property type="nucleotide sequence ID" value="XM_056933057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XBY0"/>
    <dbReference type="GeneID" id="81623306"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000725">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="268"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5488565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="360" mass="39190" checksum="C762C94CB13EE9D6" modified="2023-11-08" version="1">MSSNQFTLASPPTDAISALKFSPDPNSTRLVVSSWDKNVYLYDLRDENGAVGEGKLLQKFEHRAPVLDVCFGENENEIYTAGLDWDVRKIDLNTSEQTVLSSHEAGVRSVVYSREHNLVISGSWDSTLHVHRPDAGANTQSVPATIPLPSKPFSLSLTATKLVVAMASRALHIYDLKGLALLTAQADGDTVEGNRVELEPWQRRESSLKFMTRCVACMPDDAGYASSSIEGRVAVEWFDPSPESQARKYAFKCHRQTAEDGVDVVYPVNALAFHPVFGTFASGGGDGVVALWDGISKRRIRQYQKYPSSVAALGFSGNGKYLAIAISPGFEDGKEDISDGVVRIMVKELGETEAKAKGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XC16</accession>
    <name>A0A9W9XC16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_003431</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790574.1">
        <property type="nucleotide sequence ID" value="XM_056933033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XC16"/>
    <dbReference type="GeneID" id="81623282"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF84">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5488541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="29298" checksum="2A7DF119BD49DD60" modified="2023-11-08" version="1">MSSHRTHTKIPGAPDYDSPQFWDARFASGQDVGEWLNPGEPLIDAFVKDLDGRFAETVTPRSLHLGPGVSTLGYKIQDVYQQRGWKSWNIVNVDFSAEAVRRGLESESQKPRDQAMAWHQADLLSWNDVSKLCPLGPFDLIMDKSTSDAIATSADRRLRLDTNDADDSSLSPVVREVICQIGEIDISPVDLLALHLVSLTRKGTSWMVLSYSSLRFEKRSLLNQFWSLRSRIPIKAPSGNTCSSAYTPDVYHWLYILDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XC42</accession>
    <name>A0A9W9XC42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790678.1">
        <property type="nucleotide sequence ID" value="XM_056933137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XC42"/>
    <dbReference type="GeneID" id="81623386"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="385" mass="41075" checksum="F602C57A9FCC24A4" modified="2023-11-08" version="1">MSASDMPASDMLPSLLEQLGAAKLYELSVQRDIDPLHEDLLSSLHRMQPSYNAFAQHGTNLAQRAIDMSFQCFAVRSDAATQAHKHLGTVTDTAMLFEDAVRATAEAHAALALQTCVMMDALQELHKACSSNDLENALQDVDVSFAVPAGTDPSHLPTDMLTKAELDEVLWDLYVNEPTTEQERTKPAPNATDFLTDEQMDEILGNNTVVDNNTQQAAGPDDDAAPSGNDDSQDSDATEDCPYESDVEMLDPGCYQPLGFEAVDHAPAGPGKANHTRVSSASSSSASSSTAGAPARDSEKPAFTNPFLAAASRSGIEGILALVAILTQSSNANKDTRVTASQTSPLASGIDVTSPAFSERFQGELIREIGETLMWEEQQEAAVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XC76</accession>
    <name>A0A9W9XC76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790647.1">
        <property type="nucleotide sequence ID" value="XM_056933106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XC76"/>
    <dbReference type="GeneID" id="81623355"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5488614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="227" mass="26701" checksum="F3F06957C4B90CA9" modified="2023-11-08" version="1">MAFRKSLNPEEARHIYQCALRYAQDRRQTLHQIQECRHNLMRENVDPGTLRRQIRTIALTETQLNYRRDAPSEIQELYVPIARDVFPDPDIHMEAKEIWENNEIHECYLRTWRCVQRVLLEIDDRLKCYGFAKLEKSKMAAMLEMLVTQVGRLREALVGLVIVDRFADEMDQIALSKDGKWSASSELWMVWNQMQQDMKCGCTACTPLDPVTSSEPVLEIPYLPHYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCA6</accession>
    <name>A0A9W9XCA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790692.1">
        <property type="nucleotide sequence ID" value="XM_056933151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCA6"/>
    <dbReference type="GeneID" id="81623400"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5488659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="60" mass="6647" checksum="D29AFFFBCA1CF8AE" modified="2023-11-08" version="1">MRDHYENGISTRTIGHYSNTSADDFVNNLVDKEVDQYTSSGSDGVISQGVNNAVNTYLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCG5</accession>
    <name>A0A9W9XCG5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="3">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pantoate-activating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pantothenate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_003740</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790883.1">
        <property type="nucleotide sequence ID" value="XM_056933342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCG5"/>
    <dbReference type="GeneID" id="81623591"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1300.10:FF:000002">
        <property type="entry name" value="Pantoate--beta-alanine ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000013">
        <property type="entry name" value="Pantothenate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="entry name" value="Pantoate-beta-alanine ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299">
        <property type="entry name" value="CYTIDYLATE KINASE/PANTOATE-BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PANTOATE--BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5488850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="370" mass="40700" checksum="A94055F075C2485E" modified="2023-11-08" version="1">MSRIMRGVRSFSTAASALLADASADATRSARQPLAFQIFRDVPELRQLRRQIIRNDRTLGFVPTMGALHEGHLALIREAAKENTDVFVSIYVNPTQFGVNEDLSSYPRTWDSDMAKLEKLNEELETSSAGTGRITAIFAPTSKVMYPTLPPSSEIDGHGSFVTITPLARKLEGVSRPVFFRGVATVCMKLFNATSPDRVYFGQKDVQQTVIIKRMVKDFLMDTEVRIVPTARECDGLALSSRNVYLGSRRRNIGLTLYKALTAGANAYQAGKSSRDDILGAARSLAECVLAEQCTLAPNLRALYEVDYISLADPESLEELDCVDPKRGAVLSTAFKMAPLEETNPGEDCGLGDGKVPVRLIDNFILQPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCP4</accession>
    <name>A0A9W9XCP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MoaB/Mog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_003761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790904.1">
        <property type="nucleotide sequence ID" value="XM_056933363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCP4"/>
    <dbReference type="GeneID" id="81623612"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047884">
        <property type="term" value="F:FAD diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042726">
        <property type="term" value="P:flavin-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675:SF1">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="2">
        <location>
            <begin position="112"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5488871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="390" mass="43113" checksum="EF2A84B392EBEEFE" modified="2023-11-08" version="1">MFPTFHLIALAAPRRDRSIRRSPDLQRAPTLLSILPAFYTSTLSSPSKPSIHLDSSLFFMLNRLNLLTRQLARPFGSVRAASPTLPTTSLTRRSGPFAMTSAPNSSTIHTAACLIIGDEVLGGKTVDTNSAYMAKFCFGLGIQLKRIEVIPDDEEDIMEAVRRMSDNYDFVVTSGGIGPTHDDITYQSIAKAFGLKLQLHQPAFERMKRLSRPHPKQPNFDWETPSPGLTAKLRMVELPYDPNVSAESQALFVADDLWVPIAVVNGNVHILPGVPRLFERLLLNMKPHLVPRLTDPEGKGTFRFLFSTPLPESAVAPFLTQLAAKVEPQGVKVGSYPRWGKKRNTVTLVGANKEYLESLVAEVEAGVEGKLVEKEDDLDPPSDTEHVYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCZ1</accession>
    <name>A0A9W9XCZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster assembly factor IBA57 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003907</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvT family. CAF17/IBA57 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791050.1">
        <property type="nucleotide sequence ID" value="XM_056933509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCZ1"/>
    <dbReference type="GeneID" id="81623758"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057460">
        <property type="entry name" value="CAF17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25455">
        <property type="entry name" value="Beta-barrel_CAF17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="CAF17 C-terminal" evidence="7">
        <location>
            <begin position="284"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="403"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00093447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5489017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="434" mass="48329" checksum="CC45E7526020CA03" modified="2023-11-08" version="1">MMIKHPSSICSRCLAYRRLFSTSVRRSDQLHNAPLPPDVGYTRLTNRGLISITGLDSTTYLQGLITQNMLIANDPKKRVRNTGTYAAFLNSQGRILNDVFIYPLPNSNGDQTEREWLVEVDRNELPTLLKHLKKHKLRAKLKLRALEIDERTVWSSWRNHSEPRWAAYNLEADTASPFSSSPDVVGCIDSRAPGFGSRLVTPGSDDLRSHLPDESQLAGSEVQLDSYTVRRMLHGIAEGQSEIIRETALPLESNMDLGRAIDFRKGCYVGQELTIRTHHTGVVRKRILPVQLYTGEAPSATSPIYDPSAQIPVPAQGSNINKADGRRGRSAGKFLNGVGNIGLALCRLEMMTDIALTSEGSQYSPDKEFKVSWTSESEQPSEVKLQAFVPSWIREFILAGGAKKTSARSGEVEGERARTLVEQLGEEEEAQRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDA1</accession>
    <name>A0A9W9XDA1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phyllocladan-16-alpha-ol synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_004154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791297.1">
        <property type="nucleotide sequence ID" value="XM_056933756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDA1"/>
    <dbReference type="GeneID" id="81624005"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="579"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="632"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5489264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="944" mass="105710" checksum="7D6FFDD8D92906CD" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDL4</accession>
    <name>A0A9W9XDL4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Target of rapamycin complex subunit LST8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_004286</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791429.1">
        <property type="nucleotide sequence ID" value="XM_056933888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDL4"/>
    <dbReference type="GeneID" id="81624137"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000923">
        <property type="entry name" value="Protein transport protein (LST8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="71"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="330"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5489396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="391" mass="43949" checksum="AB6E440F510893F7" modified="2023-11-08" version="1">MSVILCTAGYDHTIRFWEALSGICSRTIQHPDSQVNRLCITPDKRYLAVAGHHNVKLFDAKSSNPQPLMTFEGHTNNVTGVAFHCEGKWMVTSSEDCSIKVWDVRSGSLQRDYRHDFPVNDVVIHPNQAELISGDRGGMVRIWDLGESKCIHELEPEENSSVTSVSVASDATLLCAGTKKGNVYLWRMVQTEDKGLIIPVATFSAHHDYLNRVLLSPDVKHLATCSADHTAKVWNLDPDYPPAKIALKEWKEKQDQQAQVDPTEKTNEVDSLEAKSQGHDLLRIFDQDRHLLRLIGKDPREETPQQKFPAQPDGPPMDPANKTLFLETTLAGHQRWVWDCAFSADSAYLVTVSSDHYARLWELSTGTIIRQYSGHHRGAVCVALNDYSEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDL9</accession>
    <name>A0A9W9XDL9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sugar phosphate/phosphate translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_003983</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791126.1">
        <property type="nucleotide sequence ID" value="XM_056933585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDL9"/>
    <dbReference type="GeneID" id="81623834"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="11">
        <location>
            <begin position="30"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5489093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="374" mass="40525" checksum="C92D155DD57ED576" modified="2023-11-08" version="1">MANERSAQDDRNLEKGAAPTPAPSSGLHPAFYIALWIALSSSVILFNKWVLSSAKFNFPLFLTTWHMVFATAMTQGLAKFTTILDSRHKVPMTPSTYVRAIVPIGIMFSLSLICGNLAYLYLSVSFIQMLKATNAVVTLFATWAFGIAPYNFKTLGNVGIIVVGVIIASFGEIKFDMLGFLIQCGGIIFEALRLVMVQRLLSSAEFKMDPLVSLYYYAPACAVTNGVVTLFTDVPRMSMNDIYSLGIMTLVANALVAFLLNASVVLLIGKTSAVVLTMAGILKDILLVCASMMIFRDPVTPQQFFGYSIALAGLVYYKLGAEKIQTLSTDIRLQVGEYRRANPAKAKGIAIGVVAVIILLVLYTGAPSGVHPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDM1</accession>
    <name>A0A9W9XDM1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <ecNumber evidence="5">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_003823</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HMBS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790966.1">
        <property type="nucleotide sequence ID" value="XM_056933425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDM1"/>
    <dbReference type="GeneID" id="81623674"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.40:FF:000002">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000086">
        <property type="entry name" value="Probable porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="13">
        <location>
            <begin position="13"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="14">
        <location>
            <begin position="238"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5488933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="338" mass="36688" checksum="BE5F2DF2ED787D12" modified="2023-11-08" version="1">MATPAPATKTTFTIGTRKSKLALEQTELVSAALKKTHPECEFKIFSKETAGDLNTKIALRDFTSKNLWTEELEELMMDGQVDLIVHSLKDVPTVLPASCTLGPMMPREDSRDVLVVKQGLPYKSLAEIPAGSIVGTSSIRRTAQLARKYPHLKVLDVRGNIGTRLAKLDAEDSPYTCIILAAAGLLRLDLGDRITQYLDSSSGMLYAVGQGALGIEIQKDNVVLQSMLNKIGHWETTYACLAERNLLRTLEGGCSAPLGVETEWVQTAEGKKKLRMRSVVVSVDGQQCAQVEIDGEVDSTESAEAFGVTVAQALIEQGAGTILEEIQRQKLAKETASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDQ9</accession>
    <name>A0A9W9XDQ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_004297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791440.1">
        <property type="nucleotide sequence ID" value="XM_056933899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDQ9"/>
    <dbReference type="GeneID" id="81624148"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5489407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="173" mass="19197" checksum="D02E462A30799A00" modified="2023-11-08" version="1">MLWSIICFQSTYEELHTVGPGRIFAVAGGETEMADLDCLDQAYIHLDDKRDVVIDIADGARVVLGQRAEYMMMERSGKNVRIAARRVLEAQIDHKRDDATNFPIGLISRPLEEDTQDPRQSIEVFTALGKAFTTSPITASLSSNTVKGTTLLPPRELSHFEFSVLVHVGKPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDS6</accession>
    <name>A0A9W9XDS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791216.1">
        <property type="nucleotide sequence ID" value="XM_056933675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDS6"/>
    <dbReference type="GeneID" id="81623924"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="165" mass="18603" checksum="13F39CAC6F61889C" modified="2023-11-08" version="1">MIQVRPELAPAGRNSLRRADNPKPPVSLQRLARKNLCVDDDVEDIFGHILQYLHSGDYSVLVPAADQSSHVACEDEIDIATQDLLPLKENYFASHTDIQVKSDNSISLPHCGDGSHLCTHPKTLLVHARLYDFAARHGLEQLRNNFRWIQNTRTESSSFYGLPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDT6</accession>
    <name>A0A9W9XDT6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="2">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_004088</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791231.1">
        <property type="nucleotide sequence ID" value="XM_056933690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDT6"/>
    <dbReference type="GeneID" id="81623939"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="10">
        <location>
            <begin position="26"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="9">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5489198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="288" mass="32144" checksum="A4E43A74A5E2C8C8" modified="2023-11-08" version="1">MATAANSRIRLASGHEIPRLGFGVYKTPPEDSYRCCLEAFQAGYRHIDSAAAYKNEAGCGSAIRDSKIPREEIFFTSKVINISYDGAKETVEQTLTLAGLDYLDLMLLHKPMGGSENRKGAWKALVEAVEAGKVRSIGVSNYGVHHLEELQQHIHELQAERGGKDKGGTLSVNQVELHPWLARKELVDWCENNGVALQAYSPIVRGARFEEPYLQALAKKYNKTPAQILIRWSLDKGFIPLPKSVTPDRIKANAQVFDFELTPSEVQELETEEYSPCAWDPTVRTLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XED1</accession>
    <name>A0A9W9XED1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Casein kinase II subunit beta</fullName>
            <shortName evidence="4">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_004228</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer composed of two alpha chains, one beta chain and one beta' chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791371.1">
        <property type="nucleotide sequence ID" value="XM_056933830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XED1"/>
    <dbReference type="GeneID" id="81624079"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000003">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF39">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5489338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="264" mass="30498" checksum="A912AA0EFA193F88" modified="2023-11-08" version="1">MEDFNSETDSDYTSYWRDWFVSSRGNEYFCEIDEDYLTDRFNLTGLNTEVSYYQHALDLVTDVFDLEAEDDLREQIEKSARHLYGLVHARYIVTTRGLAKMLDKYKKCDFGKCPRVLCDGHPLLPMGQHDLPNMSTVKLYCPKCEDIYNPKSSRHASIDGAYFGTSFHSILFQVYPALLPEKSLRRYEPKIYGFRVHAAAALARWQDSCREDLQDRLAEFGMSHKFIEESDSEDENFEYGEENESARTEKVAGDGASGRMDLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEI5</accession>
    <name>A0A9W9XEI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi SNAP receptor complex member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_004167</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of several multiprotein Golgi SNARE complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GOSR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791310.1">
        <property type="nucleotide sequence ID" value="XM_056933769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEI5"/>
    <dbReference type="GeneID" id="81624018"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094:SF2">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027109">
        <property type="entry name" value="Golgi_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR027109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5489277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="226" mass="25693" checksum="1ABC2E1E47FB6CA5" modified="2023-11-08" version="1">MTSTNSGWAQLRQQARSLETQTEQLFHTYAQFSSLTKPPQYPTDEELRLESQLKDILERREAIISQLSRLLDSEATLTSSALKQNNLARHREVLADHRRELNRLTSAIAEARDRANLLSNVRSDIDAYRASNPGAEEADYMLEERARVENSHNMIDGVLSQAYAINENFGIQRETLASINRRIVGAASKVPGMNYLIGKIGTKKRRDAIILGCFIAFCFLMLLYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF54</accession>
    <name>A0A9W9XF54_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_002687</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a zinc transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792249.1">
        <property type="nucleotide sequence ID" value="XM_056932290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF54"/>
    <dbReference type="GeneID" id="81622539"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF5">
        <property type="entry name" value="ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="171"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5491120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="465" mass="51066" checksum="58CC49419C567AE9" modified="2023-11-08" version="1">MASNLPLPIPPRTPTPPPDEAHDHHASLINTAVPMDRDALSPLRESFPRTMPLDAGTSDRWSPTKSAFTLSPGRADNSTSADNGPSEPSSASPFNFNTTVMAKGPVVKSNIGQRRGHKYKHSSISHQIFLEPPPRAPLALPNSLPIPTWKECRASMSREQKTRFWWSVCHMFVAAYTLWTAHGSLAMTALSHLILFDSLGALLCVAVDILGNFEVWKRSSIRHPFGLARTEVLAGFAMCVLLLFMGMDLISHNLQHFLEKSGHEPHHDHDHERASVGRVDITALLAISSTLVSAIGLKNHARIGKAMRFGYIKSLPSVLSNPSHFLTLSCSTLLLLLPLVSVRIYDWLDKLLSGTIAISMCMLGVRLVKTLGSMLLMSYSGPGVPEVIKDIEADPAVYGVDDARFWQVHYGLCMANLKIRVGGSEETTSRLREKISSLIRNRLGGGYGTGSQKWEVTLQLTIEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF66</accession>
    <name>A0A9W9XF66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="3 14">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">N7539_002563</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="16">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="3 14"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792125.1">
        <property type="nucleotide sequence ID" value="XM_056932166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF66"/>
    <dbReference type="GeneID" id="81622415"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3000:FF:000001">
        <property type="entry name" value="tRNA(His) guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028980">
        <property type="entry name" value="tRNAHis_guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="18">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="19">
        <location>
            <begin position="141"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="221"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR028980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ5490996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="298" mass="34638" checksum="8B6A7D31B3BC4671" modified="2023-11-08" version="1">MANSKFEYVKDFEQPDALLPNTWIVVRIDGRGFHKLSDHYAFVKPNDRRALDLMNAAAVAVMKDLPDLCIAYGVSDEYSFVFHPTCQLFERRNAKLVTTIVSTFTAYYIHLWSTYFPSKPLQPPYLPSFDGRAVIYPSARILRDYMSWRQVDCHINNLYNTTFWTMVQQGDMSNTDAEQELKGTVSADKNEILFKRFGINYNNEEEIYKKGSVLYRQYELQQPSQEHEVGDEDESSISEPKQSRSQQDKLKKLRRKAQVVVDHVDIIRDEFWQRRPWILSGKPGKLPAADSNDTQATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFP8</accession>
    <name>A0A9W9XFP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ADP-ribosylation factor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_002863</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792425.1">
        <property type="nucleotide sequence ID" value="XM_056932466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFP8"/>
    <dbReference type="GeneID" id="81622715"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="145"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5491296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="203" mass="23487" checksum="431FF762A5B48876" modified="2023-11-08" version="1">MLSILRKARLKDKEMRILMLGLDNAGKTTIVKKIMNEDVTTVSPTLGFIIKTIDFEGYKLNICKPTCIRSWFWKKMRRSIMAALTTISRGRGWSKDPANYFEKTDTLVWVVDATDRLRVDDCRQELAGLLLEERLMGATLLVFLNKTDVEHCMTEDEVRQRLELDLIVTHKWTILPCSAMTGKNLIEGLNWVVQDAKDRLFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFP9</accession>
    <name>A0A9W9XFP9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">N7539_002480</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product. May indirectly play a role in chromatin function and transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LTN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792042.1">
        <property type="nucleotide sequence ID" value="XM_056932083.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81622332"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16491">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000038">
        <property type="entry name" value="E3 ubiquitin-protein ligase listerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054477">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054476">
        <property type="entry name" value="Ltn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039804">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22958">
        <property type="entry name" value="Ltn1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22999">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01197">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="12 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="1575"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1628"/>
            <end position="1657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00055150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ5490913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="2001" mass="220825" checksum="F383648FBF285466" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG39</accession>
    <name>A0A9W9XG39_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial outer membrane translocase complex, subunit Tom5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_002705</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792267.1">
        <property type="nucleotide sequence ID" value="XM_056932308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG39"/>
    <dbReference type="GeneID" id="81622557"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019603">
        <property type="entry name" value="Tom5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10642">
        <property type="entry name" value="Tom5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5491138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="49" mass="5401" checksum="2463D65D55033B38" modified="2023-11-08" version="1">MFAPGQEQLSKEEIRAGEIEASQTVQMAVLGGVLLYLSPFAIDFARKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG40</accession>
    <name>A0A9W9XG40_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_003058</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="14"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792620.1">
        <property type="nucleotide sequence ID" value="XM_056932661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG40"/>
    <dbReference type="GeneID" id="81622910"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23285">
        <property type="entry name" value="beta-trefoil_MIR_PMT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000044">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 14 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="634"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="726"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="324"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="393"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5491491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="775" mass="88387" checksum="07520B8C17606562" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGU6</accession>
    <name>A0A9W9XGU6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-homologous end-joining factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_001487</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the XRCC4-XLF family. XLF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793121.1">
        <property type="nucleotide sequence ID" value="XM_056931090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGU6"/>
    <dbReference type="GeneID" id="81621339"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045027">
        <property type="term" value="F:DNA end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22285">
        <property type="entry name" value="HD_XLF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.10">
        <property type="entry name" value="DNA double-strand break repair and VJ recombination XRCC4, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052287">
        <property type="entry name" value="NHEJ_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053829">
        <property type="entry name" value="XLF-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015381">
        <property type="entry name" value="XLF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038051">
        <property type="entry name" value="XRCC4-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235:SF1">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09302">
        <property type="entry name" value="XLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21928">
        <property type="entry name" value="XLF_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XLF-like N-terminal" evidence="9">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="XLF-like coiled-coil region" evidence="10">
        <location>
            <begin position="124"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="256"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="339"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="510"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5492741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="549" mass="60807" checksum="3E086FF768E6E412" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH73</accession>
    <name>A0A9W9XH73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_001570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793204.1">
        <property type="nucleotide sequence ID" value="XM_056931173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH73"/>
    <dbReference type="GeneID" id="81621422"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5492824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="216" mass="23356" checksum="6EBDFF1EB963312F" modified="2023-11-08" version="1">MATRSTAAASHLQQPGLSRMDALKYLDSVQLLPVQSLPNAVQAINTVSDALQKLQDKRRAAAEPERPVVLIVAGLDTLTEAVIRASNPLRGTALLAATLRNVNRLARTHESWLSIILVNTSGLGPAHYDLTPSVETDQAEKPRKEMPRKVSGEDSIYSVFPSPSGPLLSTLLMKTLDQGIDTHILLSNVKAAQVAEVIKDRTGSGLGKWGIWSPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHC0</accession>
    <name>A0A9W9XHC0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribose-phosphate pyrophosphokinase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_001629</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793263.1">
        <property type="nucleotide sequence ID" value="XM_056931232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHC0"/>
    <dbReference type="GeneID" id="81621481"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000063">
        <property type="entry name" value="Phosphoribosylpyrophosphate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000030">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000047">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF36">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5492883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="428" mass="46183" checksum="02A25872D8A10CF3" modified="2023-11-08" version="1">MVRNLVVIGGTSHPQLTQSICDVLGIPPAEVLLSKFAVGETRVEIQESVRGKDVYIIQSGGGKVNDHLLELLITISACKTASARRVTAVLPLFPYSRQSDIPYDKAGAPLVKSSVRDRPNNGYTFESTPPTPGPGMKSEGLGLQGGIDNLQKSLAKAQIEESTGSPVKRRTANGLARSETTDSVKSLAGDDSSCNSSKINAFQPRPGYKQWVAQAGTLVADLLTCAGADHIITMDLHDPQYQGFFDIPVDNLYGRPLLKSYIQRQFPGDKSHIVVVSPDAGGAKRATAIADSMGIPFALIHKERRPTKITDRQNATMMLVGDVRGKTAILIDDLADTSNTITRAAKLLKKEGAMKVYALVTHGILSGDAIDRINASALDKVVVTNSVDQTDHLRRCPKLEVLEVGHVFAEAIRRVHHGESISVLFQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIC4</accession>
    <name>A0A9W9XIC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_001816</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793450.1">
        <property type="nucleotide sequence ID" value="XM_056931419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIC4"/>
    <dbReference type="GeneID" id="81621668"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000029">
        <property type="entry name" value="Glutamate carboxypeptidase Tre2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF71">
        <property type="entry name" value="CARBOXYPEPTIDASE TRE2, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="298"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="6">
        <location>
            <begin position="487"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="5">
        <location>
            <begin position="732"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5493070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="859" mass="95700" checksum="E39A5E1472EF5306" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIX5</accession>
    <name>A0A9W9XIX5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_001950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793584.1">
        <property type="nucleotide sequence ID" value="XM_056931553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIX5"/>
    <dbReference type="GeneID" id="81621802"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000069">
        <property type="entry name" value="Seryl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="216"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="106"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5493204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="551" mass="61036" checksum="7CDF57D8BA8E49FA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLE5</accession>
    <name>A0A9W9XLE5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ferrochelatase</fullName>
            <ecNumber evidence="12">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_000235</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="12"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794132.1">
        <property type="nucleotide sequence ID" value="XM_056929839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLE5"/>
    <dbReference type="GeneID" id="81620088"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000003">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5495119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="428" mass="47492" checksum="EEA2C79790DFCADD" modified="2023-11-08" version="1">MSFRGPFAIPRRVWTSASTSVLRPMPRSCLGFASHQRCGMATVVPPVTQDTTGSKGPTAMVFLNMGGPSTTNEVEDFLGRLFADGDLIPLGRFQSYLGPLIARRRTPKIQKQYAEIGGGSPIRKWSEYQCEEMCKLLDKMSPETAPHKPYVAFRYAAPLTETMYNQLLADGFGNGKGGRAVAFTQYPQYSCSTTGSSLNELWKWRTRLEGKRANGEPEPAGAIEWSVIDRWPTHSGLVEAFAQNIEAQLKTYPEEKRDKVVLLFSAHSLPMDVVNRGDPYPAEVAATVHAVMQRLNFSNPWRLCWQSQVGPKAWLGAQTQDTVMEYVKRGQSDLILVPIAFTSDHIETLYELDLEVMHEANSPGVKRAESLNGNPVFIQALADIAHAHLKTGEPCSAQMTLRCQGCKSERCLESKKFFAGKQHGSLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMD2</accession>
    <name>A0A9W9XMD2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Monothiol glutaredoxin-5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_000743</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <location>
            <begin position="62"/>
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            <dbReference type="ARBA" id="ARBA00023284"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00067618"/>
        </source>
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            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5495627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="159" mass="17207" checksum="7C1EC1F498A2827A" modified="2023-11-08" version="1">MFSRTVFSALRPISRPSSLTTPLRTSLAPRAPAFTIPSALHARLLSSETRAAIDKAVASAPVVLFMKGTPETPQCGFSRASIQILGLQGVDPSKFVAFNVLEDAELRQGVKEYSDWPTIPQLYVDKEFVGGCDILMSMHQNGELAKMLESKGVLVAADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMD8</accession>
    <name>A0A9W9XMD8_9EURO</name>
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            <fullName evidence="5">PAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">N7539_000808</name>
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    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">IBT 30728</strain>
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    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">IBT 30728</strain>
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    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5495692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_056930412.1"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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            <end position="493"/>
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            <begin position="406"/>
            <end position="421"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5495692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="611" mass="68439" checksum="968BDEAAC4954015" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMN3</accession>
    <name>A0A9W9XMN3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin-like protein AAED1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056930547.1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29662" checksum="5C9607E3F178B9D7" modified="2023-11-08" version="1">MSYEVDASTGPNPTVTVIDPPVKNPSSTMESAPPAADDVNAALPDAHRKRDEELPSTKTLEKVADYSVLDKSGDKRTFKSLYEGPGSTRRVLVIFIRHFFCGSCQAYVQTLSESFTPEQLLHLPTPTSIVIIGCGDPSLIDFYAKETNCPFSIYADPKTKLYDELGMTSTYALGAQPKYIRKGLARMVTQSIMQELRNIGSALTMKGGDTKRVGGEFLFESSEGQTGEKRVSWCHRMTTTRDHAEVEVLSRILHVDGTELVKEEQNVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMQ1</accession>
    <name>A0A9W9XMQ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_000908</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794805.1">
        <property type="nucleotide sequence ID" value="XM_056930512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMQ1"/>
    <dbReference type="GeneID" id="81620761"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00300">
        <property type="entry name" value="ChSh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="64"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5495792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="253" mass="29194" checksum="2BCCE3D02F65F12A" modified="2023-11-08" version="1">MPPPIEDISDEESGDIPFDDKNGAKEDVNVKDDAADAADEEEEEEEEEEEEEEEEEEEEEEDVFVVEKILDHAWMDDGSFKLHVKWKGWDKPEDLTWEPESSLKSGAKQILDAYYKKIGGRPRKNAAKPAPKAGPGRKRKSMNHVKEPSASVEPAESKRSRRKSSAPAVEESNPEAASEEEEHYFSWTPKVKDWGSQLERVDTIIRDQETKSLYAFLLWKNGRRSRVALETCYDKCPRQMLEFYENHLVFKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN50</accession>
    <name>A0A9W9XN50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795084.1">
        <property type="nucleotide sequence ID" value="XM_056930791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN50"/>
    <dbReference type="GeneID" id="81621040"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF100">
        <property type="entry name" value="SAM BINDING MOTIF CONTAINING PROTEIN (AFU_ORTHOLOGUE AFUA_4G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="101"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5496071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="393" mass="43598" checksum="B9B8B56A639B3BB6" modified="2023-11-08" version="1">MSAGTSSLAAAAASGSDIHSNLSSNFAANSSSSLGSLTDYSNYPLARHGDRTYLRDPENFYPLPCDLPEIHRQSLRTTMLLRVFGGPFCNPHLADRPPKRILEIACGSGLWSGLCHEYLAGQGHPNVSFVGIDVVSLAPDLRKRGVNWQFKRHDLRRSRLPFPDNFFDLVFIKDAGMCPSSPAQQASGLEEPLRVLRSGGVLEVWDSDWVFRSLLPNPAPARKAPVHAQETADSTGTYTFSPATPFTQVQNKYLVDYNSWVEKSFDRRKLTALPCATIGLAFNSEVDLLENVDSRRIAIPLGESRWEREGQGKDSKGRIRKALTPEQIAIRRTALLTVVQMIEGMEPMLMEASGKSRDEWDRWWAAMNSDLFLKGGLASGECLEVSAWWGVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XNP8</accession>
    <name>A0A9W9XNP8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ER membrane protein complex subunit 7 beta-sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_000705</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794602.1">
        <property type="nucleotide sequence ID" value="XM_056930309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XNP8"/>
    <dbReference type="GeneID" id="81620558"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040838779" description="ER membrane protein complex subunit 7 beta-sandwich domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="8">
        <location>
            <begin position="36"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5495589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="274" mass="29165" checksum="1887004F3931AAB7" modified="2023-11-08" version="1">MHLRLSSLLGLGLSLSYLATASLLTITIPPSTNLPNPHSLPASTHATLTTLPAPGAGDRDPPHILTASLTRGATLVFRDLPAGHPETYLLDIRAGEYVFAPYRVDVAADGSVTGIWETFRGNPWENRGAQKYVVDVVAGEERRPETAGEDVLVEAKLLGKKAFYEERASFSPLSLLKNPMILMAVVALVLTFGMPKLMENMDPEMRAEFEQQSRSSPLTGATNNAIAGGGFDLAGWMAGTAPSPMAVAQAREAQERESASGREAAAAGNVKKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XP34</accession>
    <name>A0A9W9XP34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795008.1">
        <property type="nucleotide sequence ID" value="XM_056930715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XP34"/>
    <dbReference type="GeneID" id="81620964"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="626" mass="68745" checksum="EAD27A3697F3383B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJA2</accession>
    <name>A0A9X0BJA2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phenylacetate 2-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_009512</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Aromatic compound metabolism; phenylacetate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785602.1">
        <property type="nucleotide sequence ID" value="XM_056939107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJA2"/>
    <dbReference type="GeneID" id="81629357"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11066">
        <property type="entry name" value="CYP_PhacA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000072">
        <property type="entry name" value="3-hydroxyphenylacetate 6 hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0349">Heme</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5466556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="516" mass="58253" checksum="D9A378BE29C57786" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJD7</accession>
    <name>A0A9X0BJD7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785722.1">
        <property type="nucleotide sequence ID" value="XM_056939000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJD7"/>
    <dbReference type="GeneID" id="81629250"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5466676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="357" mass="40570" checksum="545A6614466E4BDE" modified="2023-11-08" version="1">MAEVDDALPSSLLDAIRTQLRIDSDSESSQSTVITVLDARGQPSSPTTPLDEEMSSPADVSPNPVSVSACSSQIHDTEPFPSFDEGYSEEQREWDHDFQASIMTAMQAQIRRENIDQAIIAPANQPEKKQRTLDRVKEHLSNPQMRSSTRERFIALTNMVIRLDHVLYERSEEFLGMADVAAAAEIVEVILRYLRWMDEMLGGLVATAENVFGAFHFLSAENVPAIFMFRQMSKVASAHLRKPKVLEQQLLSLYLDLFDEWVHERFLHLSNRKILQDNRIEPDCLQLIGHVHDVWELLMRSVRNYAAYTAQLEHIRLVYLTPVFTMTEIAVAPEIVSFSLSGEPLQGPEEEDKDETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJT8</accession>
    <name>A0A9X0BJT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Endocytosis protein end4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_009185</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLA2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786157.1">
        <property type="nucleotide sequence ID" value="XM_056938780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJT8"/>
    <dbReference type="GeneID" id="81629030"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1410.10:FF:000004">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000021">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF15">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
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                <person name="Nielsen M.R."/>
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                <person name="Frisvad J.C."/>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <comment type="caution">
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="178" mass="20151" checksum="08D8A8DE77773D84" modified="2023-11-08" version="1">MRTRVLHYYTLPPSPDCARTGTSKDRPPLLIPPSSLPRARFPEPFGPFLFFFLSHATTFFLSLLLLLLLLLPPPPPPTLLFFIHLLFLETHCPIIDFLPPSLPLILPFHSPISPPLIVRPPPPPTLSTILISSPFIASSPSTSFHHLLLDLRHTLAFFFHPPPVPRRTTIDRSTQIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BN15</accession>
    <name>A0A9X0BN15_9EURO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">N7539_008292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786984.1">
        <property type="nucleotide sequence ID" value="XM_056937892.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81628142"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATOR SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="674"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5475226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="703" mass="76896" checksum="4FA31435D01CE708" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BN86</accession>
    <name>A0A9X0BN86_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_007723</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787189.1">
        <property type="nucleotide sequence ID" value="XM_056937324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BN86"/>
    <dbReference type="GeneID" id="81627573"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
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        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052450">
        <property type="entry name" value="TRBD-Containing_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734:SF1">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1 TERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="315"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="315"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="320"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="527"/>
            <end position="659"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="79"/>
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            <end position="556"/>
        </location>
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            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5475436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="659" mass="71859" checksum="865AC8ADA566B2FE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNJ9</accession>
    <name>A0A9X0BNJ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Early meiotic induction protein 1</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">N7539_007133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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        </lineage>
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            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5476989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787533.1">
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    </dbReference>
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    <dbReference type="GeneID" id="81626983"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5476989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24364" checksum="BC2659D61B5649AA" modified="2023-11-08" version="1">MGWLWNSNISEETPKVTTGAATSIPESRLPSSTPPKQLSPDEQADLEFKQIIAELQQADAELNSNQRRGPDSYNGTTTAPANPDTSAPLAQPASSIAPESLYADTMSCRTAFDYAFFCQSFGGQFVNVYRYGELRSCSEHWDNFWLCMKTRGWSDELKRKAIRAHNQKKAIKYRTGPSSEDVWDVRLEPASDSFKGDFAALEKEMKAEEEMKQKAAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSD4</accession>
    <name>A0A9X0BSD4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Polysaccharide synthase Cps1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_006904</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788440.1">
        <property type="nucleotide sequence ID" value="XM_056936505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSD4"/>
    <dbReference type="GeneID" id="81626754"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06434">
        <property type="entry name" value="GT2_HAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5481010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="51090" checksum="8A2DF916EBE1FA35" modified="2023-11-08" version="1">MTFPFLRAFVALFCYRYFRLVVNLWSFWNFKPIPPPENPKLSSQDVTVIIPTLEGCGDELVETIRSILENQPYEILLVTIEANRKRAEKMLSAMPASDARIRLFTVTHPNKRRQMTRAIPEVRTSITLLADDDVSWPSTVLPWILAPFEKDERYGGVVTCQRLRRAASPTFSQRIWGFLGALYLERRNFDCGATTNMDGGLPCMSGRTVAYRTKILQDDGFTYAFTNEEWWWGKYQLNADDDNFITRWMVSHGWETFMQYHPEAEVLTTLEDNPVFLKQCARWSRSNWRSNLTSMFHEKHIWYRQPWSAYAVHMTTLSPPALLGDLLLVWLCHKATASWGEVSHDRAMTFLYLWMFTSKWIKLLGHYIRYPVDVFLLPVSILFGYFHGAIKMYAVMTLNVTTWGSRDGADDYDAERMKKRTDADRTKQPYYPSYLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BST3</accession>
    <name>A0A9X0BST3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase S59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_006202</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788728.1">
        <property type="nucleotide sequence ID" value="XM_056935804.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81626053"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2360:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein Nup98-Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.690:FF:000003">
        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1610.10:FF:000003">
        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="12">
        <location>
            <begin position="901"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="66"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="405"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="649"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1051"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1125"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1195"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1289"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="436"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="539"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="588"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1068"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1126"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1158"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1196"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1289"/>
            <end position="1304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5482756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="2013" mass="213150" checksum="64F86519BF4725CC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSU8</accession>
    <name>A0A9X0BSU8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP12-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_006905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788441.1">
        <property type="nucleotide sequence ID" value="XM_056936506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSU8"/>
    <dbReference type="GeneID" id="81626755"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5481011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="40482" checksum="D2C71F4B23879322" modified="2023-11-08" version="1">MTTVFTRNALSARFLSVHRQNLAVSSRHIHSSLLRAAVAHPLTAHGPPPKAPAASPVLAETNETQTLSTSTLGAQDVSQVKKPSPLKKRFWKDVHVHGKTGEYQVLLDKRPVRTPNKDILSIPATKPHLAHAVALEWDVMTSAQHALKSHLIPLTSLAARAADIVREDAAGERTTRDQIVTTAMRYLDTDSLLCWEPERQRNALDRVGETGSVESLRNIQMRVAKEIMAFLSTKVWPSLEIVPILDTESIMPVSQPRGTQESIRAWLYELNAHDLAGVERAILASKSLLVAVRLMVEWSENFRHLQRQGVKKFGLEEATEAANLEVQWQTDMWGEVEDTHDVDKEDLRRQLGSVVILVSGETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BTX3</accession>
    <name>A0A9X0BTX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_005853</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789327.1">
        <property type="nucleotide sequence ID" value="XM_056935455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BTX3"/>
    <dbReference type="GeneID" id="81625704"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000496">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="9">
        <location>
            <begin position="168"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="510"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="544"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5484057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="653" mass="74226" checksum="38F794972F9E86DE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUH9</accession>
    <name>A0A9X0BUH9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790002.1">
        <property type="nucleotide sequence ID" value="XM_056934808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUH9"/>
    <dbReference type="GeneID" id="81625057"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="252" mass="28171" checksum="704ACAC6F82081BD" modified="2023-11-08" version="1">MPSLIPRWKKKPPSSFENLSPSDRDYLIDVLRATAPSPPSNNNRAEEKRSHRPARGSLLPKQPSTAEPNPPTPDTGSISSSPQQTQKQPRSIPLQTIQQTPTQTRTQPQPQPQPQQQPSDEPTLQQFLQAATDILKTWESPDPSAPSSSPPISNLDKQILARKFSIGVSSCMKDYADKTRPVTGSSRGHIHRVLEQCVLVKRKLREIEFALRERDGGEVLSEVTRQTVGDTWRVMVSLGKDSWIDVDYALRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BV47</accession>
    <name>A0A9X0BV47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome quality control complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_005600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790396.1">
        <property type="nucleotide sequence ID" value="XM_056935202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BV47"/>
    <dbReference type="GeneID" id="81625451"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.310.10:FF:000003">
        <property type="entry name" value="Zinc knuckle domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="8">
        <location>
            <begin position="552"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT protein C-terminal" evidence="9">
        <location>
            <begin position="971"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="435"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="702"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="910"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1085"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="327"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="710"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="740"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="756"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="780"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="795"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="825"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="913"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="923"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="941"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1089"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5485612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1120" mass="124245" checksum="93D4DE84D1353EC7" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BVC8</accession>
    <name>A0A9X0BVC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790304.1">
        <property type="nucleotide sequence ID" value="XM_056935110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BVC8"/>
    <dbReference type="GeneID" id="81625359"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="367" mass="40990" checksum="1C56D5F92E4A0DBA" modified="2023-11-08" version="1">MAGEVRQPIDVPSLARYLDQNVPEVKTPIEIKQFGFGQSNPTYQLITADGRKLVLRKKPPGKLLSKTAHRVDREYQIIKALGSTNVPVPEALCLCEDSNVIGTPFYIMEFLDGRHFVDPTMPGVSPEERTALWKSAVETLAKFHSVVPQSVGLEKFGKSSGFYDRQIATFTAVSQAQSEVLDKDTKEPVGELPHFKDMVNFFSQKSTQPRDRGTLVHGDYKIDNMIFHKTEPRVIGILDWEMATVGHPLSDLCNLTSPYVMDGAENSKDEFQPGRVPGLPRREDCVRWYAAVSGYNPADDMLWGDAFFAFRASVIMQGIAARYAARQASSARAAEYGSRAKPFALEAWGRVKQVQDLSRQKSQKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXM9</accession>
    <name>A0A9X0BXM9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_003393</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790536.1">
        <property type="nucleotide sequence ID" value="XM_056932995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXM9"/>
    <dbReference type="GeneID" id="81623244"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="209"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="381"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5488503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="410" mass="45522" checksum="EB303D6D97BFD63A" modified="2023-11-08" version="1" fragment="single">DLGINMESTPRQNRQPTVRHTANTDETYPSASLLARDTVSSSNATTHLPVGLGISNCGLESIYTQAAPIPHHVSFPINSMTPHHAITPTHNHLLSLQADDFCGMSCYEIYNTTPDGTNPLPDDPAAQSLAVYPGFQPSFDYRHEPCISLDKNSGLNNHWMDISTPGSMTPPHNVNNVAVPAPYGHWSGEYLTQSGVNLQQALPVMTHSELQSFGPPLPHSDLSRPCKSESMATAALEPQNVDSGPTETVSDYSSAKTSKRGRKPSVEKGCKCPVCGYYFTRRSNCVAHQKKHDPTYHRAIPCEECPKSFGRNADLRRHVDTVHRGIRKHVCKWCSRRYTRWENMTKSVQSFSRRITFDSTHLLTSEPNPMAFRHLVECRERPADARTPTPPPPSSLEAECDSLNSLQVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXW7</accession>
    <name>A0A9X0BXW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">General transcription and DNA repair factor IIH subunit TFB4</fullName>
            <shortName evidence="14">TFIIH subunit TFB4</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">RNA polymerase II transcription factor B subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_003799</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the TFB4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790942.1">
        <property type="nucleotide sequence ID" value="XM_056933401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXW7"/>
    <dbReference type="GeneID" id="81623650"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000084">
        <property type="entry name" value="Transcription factor TFIIH subunit Tfb4, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5488909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="383" mass="41168" checksum="5D49FCEB23FB18AA" modified="2023-11-08" version="1">MNSVDASEHYELNATELAPSLLTIVLDTNPHAWASLESSLPLTKAVANLLVFINAHLACNYANEVAVVASHTTKATWLYPVHDDDVSQQQPADADGDVAMNGENGTGSQTNKYRPFRMVEERVTQRLKQLLDSTNSDDLRGNTSTMLAGALTLALSNINRQTIAWAEKHGGADLEDAAGDGGTGGGNAGSTGPGRYSASNDEERLQSRILIVSVSGSSDSAHQYIPVMNSIFACQRLHIPIDVCKLSGDAVFLQQACDATKGVYMALSEPRGLLQYLMMAFLPDQRSRKHLVLPTRVDVDFRAACFCHRRVVDIGYVCSICLSIFCEPPPDNECLTCGTPLDVGDFGSKPALIPRKKKKKKRVNGTSTVGTPMSTGTPPPGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXZ0</accession>
    <name>A0A9X0BXZ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein ESF2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">18S rRNA factor 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pre-rRNA-processing protein esf2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_003557</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790700.1">
        <property type="nucleotide sequence ID" value="XM_056933159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXZ0"/>
    <dbReference type="GeneID" id="81623408"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="288"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5488667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="353" mass="40530" checksum="7BDCE53E5F4AF681" modified="2023-11-08" version="1">MTTRKHNEFLDVASDEDEVDVRGYSSEENDAKSKGRAVKKRRTDTQDFFGLESDEDLSEEEEDETSRSDVKGKGRKQLRPKTKSAGTSSQDVEREETDADEDDEHKEGDEKEHAKDDHESPEQKKFKKVLSTKLLKKPKKDKSGVVYLSSLPPYLKPFALKNIMEKRGFGPIRKVFFAPLVPSNSSSQRKSNKRKLYSEGWIEFESKKTARLAAEAMNARPLGGPKGMYYRDDVINMRYLSGFKWADLMETVQRERSERESKQRMADIRARKEEKVFLAGVEAGRRLDGITQKNEEKRKRKAEAEGQVEGDKKEPKMPAPVRRRFVQNDVVTTTQKSEKAIDNDAKRVLGKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY84</accession>
    <name>A0A9X0BY84_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790970.1">
        <property type="nucleotide sequence ID" value="XM_056933429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BY84"/>
    <dbReference type="GeneID" id="81623678"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5488937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="117" mass="13494" checksum="ECA3366338B695B7" modified="2023-11-08" version="1">MDYIIYIGDDVIMTRATLRMKHEQAVKTVHEDLKSNSKAMYSREDLTKLRVSLETSDTQDLPGTGTRLFEPMAPDKISRYSFDASKMSKDDREFHGIYDTCYRPRKGTARIPESHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYA1</accession>
    <name>A0A9X0BYA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell cycle control protein cwf18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791689.1">
        <property type="nucleotide sequence ID" value="XM_056934148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYA1"/>
    <dbReference type="GeneID" id="81624397"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013169">
        <property type="entry name" value="mRNA_splic_Cwf18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08315">
        <property type="entry name" value="cwf18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="21917" checksum="2765D9F2E948F388" modified="2023-11-08" version="1">MSSSHASLDAASNDRKARLAKLAALKRKQPEPEEPSIADLNAESADREQAASDVTTKFLSGRNYDAETRGPKLGFEQGPQEGKVTVEAQAAEIAETVKDQAQKDAEADQPIDLFKLQPKKPNWDLRRDLDEKLKILNVRTENAIARLVRERIESAQRAAKARGSKSTGEEGEEVGIEGDALVEGIHMREQEVDNDEDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYB6</accession>
    <name>A0A9X0BYB6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 20">Serine/threonine-protein kinase Tel1</fullName>
            <ecNumber evidence="5 20">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">N7539_003932</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 20">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Chromosome</location>
            <location evidence="2 20">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5 20"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791075.1">
        <property type="nucleotide sequence ID" value="XM_056933534.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81623783"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000025">
        <property type="entry name" value="Serine/threonine-protein kinase Tel1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000019">
        <property type="entry name" value="Serine/threonine-protein kinase Tel1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021668">
        <property type="entry name" value="TAN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11640">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01342">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 20" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7 20" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11 20" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 20 25" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="15 20" id="KW-0779">Telomere</keyword>
    <keyword evidence="9 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="23">
        <location>
            <begin position="1842"/>
            <end position="2439"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="22">
        <location>
            <begin position="2543"/>
            <end position="2854"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="24">
        <location>
            <begin position="2865"/>
            <end position="2897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="173"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="2825"/>
            <end position="2853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU365027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAJ5489042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="2897" mass="325213" checksum="C135AFD59A32FB98" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYC1</accession>
    <name>A0A9X0BYC1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_004279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791422.1">
        <property type="nucleotide sequence ID" value="XM_056933881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYC1"/>
    <dbReference type="GeneID" id="81624130"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5489389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="64" mass="6832" checksum="C33038CB4D357E0E" modified="2023-11-08" version="1">MSPSVLSPAHVAFKTLDGEDGLLVIKGVWTPTEGMTELHVSSLRADPFFAPPKAVKALVSKIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYC2</accession>
    <name>A0A9X0BYC2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_004530</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791673.1">
        <property type="nucleotide sequence ID" value="XM_056934132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYC2"/>
    <dbReference type="GeneID" id="81624381"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000020">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001075">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2130:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="32"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="237"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5489640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="671" mass="74851" checksum="EF5F995ABCEB054F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYC6</accession>
    <name>A0A9X0BYC6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 14">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_004606</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 14"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791749.1">
        <property type="nucleotide sequence ID" value="XM_056934208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYC6"/>
    <dbReference type="GeneID" id="81624457"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16866">
        <property type="entry name" value="PHD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="288"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="MYST-type HAT" evidence="17">
        <location>
            <begin position="602"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="190"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="423"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="566"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="896"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="987"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="566"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="999"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1095"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1177"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1222"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5489716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1247" mass="138570" checksum="479DC0510126CF7E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYU8</accession>
    <name>A0A9X0BYU8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Epoxide hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_002603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792165.1">
        <property type="nucleotide sequence ID" value="XM_056932206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYU8"/>
    <dbReference type="GeneID" id="81622455"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02603">
        <property type="entry name" value="HAD_sEH-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5491036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="29062" checksum="F93234A2D9C02A53" modified="2023-11-08" version="1">MAVDKRPIGLLFDIGGVCVVSPFQAILDYEVAHSIPPGWVNFSISRTSPNGSWHKLERGQIPMDADFFAGFNADLQNSDLWKQFNEQLAKKKGQSPGPIPPLPKVDAEWLFWEMMRISRKPDPHMFPALQKLKASGQFLMGALSNTVKFPDGHDYNNDVSGVRSQFDFFISSAHTGLRKPDPKIYEVALQEMQALAKQRGLPAVQASDIVFFDDIGENLKGARKAGMRTVKVTLGRIEDAVKELEKLTGLPLLEEQGKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ12</accession>
    <name>A0A9X0BZ12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_002365</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791927.1">
        <property type="nucleotide sequence ID" value="XM_056931968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ12"/>
    <dbReference type="GeneID" id="81622217"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000636">
        <property type="entry name" value="ATP-binding cassette sub-family D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF69">
        <property type="entry name" value="PEROXISOMAL LONG-CHAIN FATTY ACID IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="779"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5490798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1024" mass="114420" checksum="458A610A3D00496E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZB0</accession>
    <name>A0A9X0BZB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_002559</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792121.1">
        <property type="nucleotide sequence ID" value="XM_056932162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZB0"/>
    <dbReference type="GeneID" id="81622411"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000047">
        <property type="entry name" value="Mannosyl-oligosaccharide alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF101">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040942137" description="alpha-1,2-Mannosidase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="331"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5490992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="510" mass="56290" checksum="87AD4B23F2898397" modified="2023-11-08" version="1">MRVPAPLSLVALGLVGSTVAHPLVDHEEVLGRKSDSQKKAEAVKEAFQHAWDGYMKYAYPHDELHPVSNGYGDSRNGWGASAVDALSTAIIMGKTDVVNTILDHVSKIDYSQTDSEVSLFETTIRYLGGMLSGYDLLKGPAARMAHNPDLVDTLLVQAKNLGDVLKFAFNTGSGVPYNNINITSKGNDGSTANGLAVTGTLVLEWTRLSDLTGDDEYASLSQKAESYLLNPKPSSAEPFPGLVGSNIDIATGKFTDGYVSWDGGDDSFYEYLIKMFVYDPTRFALYKDRWVLAAESTIEHLQAHPEPRPDLTWLASYDSGRYSLNSQHLTCFDGGSFLLGGTVLNRQDFIDFGLELVHGCEATYNSTLTKIGPDSWGWDPKQVPNDQKEFYEKAGFYITSGAYILRPEVIESFYYAYRVTGKEIYRDWAWNAFVAINATARTDSGFAALSDVNAPNGGSKYDNQESFLFAEVMKYSYIIHAEDAEWQVQTGGKNSFVFNTEAHPVRVQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZD8</accession>
    <name>A0A9X0BZD8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">malate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_003158</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792719.1">
        <property type="nucleotide sequence ID" value="XM_056932760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZD8"/>
    <dbReference type="GeneID" id="81623009"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="148"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="8"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5491591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="330" mass="34396" checksum="8AE7D7F11C331745" modified="2023-11-08" version="1">MVKAVVLGASGGIGQPLSLLLKASPLVDELALYDVVNTPGVAADLSHISSTAKITGYLPKDDGLKHALTGADIVVIPAGIPRKPGMTRDDLFKINAGIVRDLAKGVAEFCPNAFTLVISNPVNSTVPIAAEVLKNAGVFNPKRLFGVTTLDVVRAETFTQEFSGLSDPSKATVPVIGGHSGETIVPLFSQVSPDFKIPADRYDALVNRVQFGGDEVVKAKDGAGSATLSMAFAGFRFAESVIKASKGEKGVVEPTFVYLPGVAGGEEIVKATGVEFFSTPVELGPNGAEKAINLLSGITEKEKSLLEACIKGLKGNIEKGVEFVKNPPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZP0</accession>
    <name>A0A9X0BZP0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Homeobox and C2H2 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_002949</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792511.1">
        <property type="nucleotide sequence ID" value="XM_056932552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZP0"/>
    <dbReference type="GeneID" id="81622801"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="29"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="266" mass="28116" checksum="680DB6B7C4C4C546" modified="2023-11-08" version="1">MPFVQSGRHNLHYADSHPSGPPTPTGLTFIFIHGLGSSQNYYFPVIHHLTASHRCITLDTYGAARSPFTGDQISINSIADDVLGVLDALHVTKAVLVGHSMGGLVVIELGVRYPDRVVGIVAIGPTHPSDTLVGAMNSRVGKVTEAGMEPMANTIPSAAVGSRSTPLQRAFIRELLLGQDANGYIALCGAISSARVPEYSAVHAPFLLIAGEEDKSAAMEGCQYILAHVGSQSKRMEVLSGVGHWHCIEAPEEVGRLIGSFAGELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C291</accession>
    <name>A0A9X0C291_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_000514</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794411.1">
        <property type="nucleotide sequence ID" value="XM_056930118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C291"/>
    <dbReference type="GeneID" id="81620367"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5495398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="530" mass="59057" checksum="3B5BC1D080E57B19" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WK71</accession>
    <name>A0A9W9WK71_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_009509</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785599.1">
        <property type="nucleotide sequence ID" value="XM_056939104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WK71"/>
    <dbReference type="GeneID" id="81629354"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF24">
        <property type="entry name" value="NICOTINIC ACID PLASMA MEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="57"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5466553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="494" mass="55184" checksum="BB873324174EE546" modified="2023-11-08" version="1">MAIDDSQTADIAVGQKFTGHKRRDSVAVDGSVAGEALDVHLDPALERRLLMKLDIAFVPIIMLTYLSCFLDRSNIGNVKVAGMPEDIRASDSQFSTAISIFYVTYVLFESPWAVLMKKLTPRNILTGLCIVWSLTTVFSGFIDSVASLYATRLILGACEAGLFPCLNLYLTMVYRREEQAKRVSYLLSCAAISGAVGGLLAYGLLHMDGVAGKAGWRWVYIIEGIFSALCAVLIWFGLPNNPAEAYFLNEEEKWMMRVRNEQRRKYMGNEEFSWQEMRIALTDPKLFFSGLIQFCQDILLYGFSTFLPTILKGMGYNTLMSNVLTVPVYIWAAAVFVFLAFCSDRYSKFASFIFASNIFGIVGYILLLTVSHKPVQYFATFLIGISTYTGVGLNVAWINVNVAPQYRRALEIGLQQTIGNCAGIVAGQIYRNPPYVLGNSFSLGALVVSQIGVTFFGFYLRRENQVKARIENDEVQDTRRVQTGDAAVDFKYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKP8</accession>
    <name>A0A9W9WKP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_008888</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785860.1">
        <property type="nucleotide sequence ID" value="XM_056938483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKP8"/>
    <dbReference type="GeneID" id="81628733"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="8">
        <location>
            <begin position="15"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="168"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="685"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="716"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="685"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5469270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="735" mass="84781" checksum="B360E7ABDBB906C5" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKX2</accession>
    <name>A0A9W9WKX2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_009017</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785989.1">
        <property type="nucleotide sequence ID" value="XM_056938612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKX2"/>
    <dbReference type="GeneID" id="81628862"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08577">
        <property type="entry name" value="PI-PLCc_GDPD_SF_unchar3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039559">
        <property type="entry name" value="AIM6_PI-PLC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5469399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="446" mass="50741" checksum="2A1E28137D7949CB" modified="2023-11-08" version="1">MGVVGGLEMVQVRLDETDTPDSPTSHAQSMEERDEAAHLLQEYGFDHDQDFDAESEVGGHGFSDTGAHEKIQTRKTRRESIIYRLSPWRCARRRCEANGCTKHSSFRRRWRRPFWIVVAVLTILCLSSFAWDRILATLADSRDVDLFTDQLIQGVVPIACHSHNDYWRHVPLFSALAVGCTGVEADIWPDGKNLRVGHTRRTVIKNQTLRSLYLDPILNILDQHNPANNVSSKDTASIIQQETFAPVGVFLTEPSQPLILLIDFKIEPETLWPILMADLEPLRQKGYLTHFNGSNIVHRPLTIVATGDAPFDRIQGNSTYRDIFYDAPLDKLSPRPSSTSSSTNTSISPYNQYNSYYASVSFRHSIGSLYLGRLSNDQLTKVQSQIATAHARGLKVRYWGTPGWPAALRNYVWRVLEREGVDMLNVDDLRAASRGTWREESWWWGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKY0</accession>
    <name>A0A9W9WKY0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785921.1">
        <property type="nucleotide sequence ID" value="XM_056938544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKY0"/>
    <dbReference type="GeneID" id="81628794"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF1">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="2">
        <location>
            <begin position="39"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5469331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="448" mass="49870" checksum="E9BB88823A640E55" modified="2023-11-08" version="1">MVEKKDIAATPPTPVSFFDPAVKHVRRQVYLQWSRIVGFLALFVLVVLSLYWGVQNDTERKLANLKVWVVDFDGQTDGSQTSNPIVGPAVINAVPQFANSQEPHLGYEVKNASEFNNDFLAVRQAVYDEKAFAAIIVNTNATELLRRAVSQQNTSYDPNGAIQTVVVTARDQSTYGSYVLPGLTNFQHAVLASFGPQWVQNLINNNTNMSSVPPQAINPAIGFTEIDLRPFKPAVAGPAVAIGLIYLIIVAFFNFPFLMPIHAQLIKPSPSNPPVKMGQWLIWRICSNILAYFFMSFFYSLVSLAYGIPFTNSPAPATVPVANANAYGHGSFVVYWMLNWVGMAALGFPCENMAMVLGAPWSALFLIFWVITNVATGFYPLEVANAFYRWGYAWPLHRIVEASRTIMFGTHSRIGLDFGILLAWIGVSIAFFPFASFIMRWKMRRGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL17</accession>
    <name>A0A9W9WL17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_008980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785952.1">
        <property type="nucleotide sequence ID" value="XM_056938575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL17"/>
    <dbReference type="GeneID" id="81628825"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000636">
        <property type="entry name" value="Serine peptidase, family S28, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF109">
        <property type="entry name" value="PEPTIDASE, FAMILY S28, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5469362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="558" mass="62460" checksum="8A496F56910FAC7A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQL7</accession>
    <name>A0A9W9WQL7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786428.1">
        <property type="nucleotide sequence ID" value="XM_056938420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQL7"/>
    <dbReference type="GeneID" id="81628670"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="222" mass="24339" checksum="69F5EA84578BD8E9" modified="2023-11-08" version="1">MQVSSNGCRFWKVGKCGIFHGVPFLMLQNISVTSGLNTIMPPNCPYAPDAVRLQEEYPLINNEDLERGTYEDLEIIFKHLPSSLKHPPGNERECTLARILCAASAFLHQIRSGGIAGRLSYYSQDKDDHNGSPSSSASRPFNIDTATPTRVTPSRIPKGSMAKGSMAKDSMDGAAAKALFDQALIEQGPLKKQILEHPARSEAKYTLGLPPIDRAFSSERIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQR7</accession>
    <name>A0A9W9WQR7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_008482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786459.1">
        <property type="nucleotide sequence ID" value="XM_056938077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQR7"/>
    <dbReference type="GeneID" id="81628327"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052031">
        <property type="entry name" value="Membrane_Transporter-Flippase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43549:SF2">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN NORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43549">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN YPNP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5471913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="515" mass="57085" checksum="C51FFFCE88281C49" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WR05</accession>
    <name>A0A9W9WR05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786457.1">
        <property type="nucleotide sequence ID" value="XM_056938075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WR05"/>
    <dbReference type="GeneID" id="81628325"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040:SF1">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5471911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="17620" checksum="808ED3049F6C15BE" modified="2023-11-08" version="1">MAFDLARIKPVVVDSVALLRSVIGEVMTLRTDTPSLLIDLEGYQLGRHGSIFVMTIYAPPKEKVYLIDIHRLGADAFSTVNADESSVILKLFFDVRHDSDALFSHYSIAIDGARDVQLMELGTRTGPKEFLASLAACVEKDSTISAKEKKTWEMTKLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTG1</accession>
    <name>A0A9W9WTG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trans-enoyl reductase fsr4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_008287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786979.1">
        <property type="nucleotide sequence ID" value="XM_056937887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTG1"/>
    <dbReference type="GeneID" id="81628137"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="9"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5475221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="357" mass="37895" checksum="C95D7258A6518F78" modified="2023-11-08" version="1">MKEVINLIGPAVKIVDSPIPEPNDDQVLIKVVVSGSNPKDWKVPEYAAAAGSSLPMFEAVKNGVNQGDDIAGIVEKVGANVVEFKPGDRVAAFHEMCVPHGSYAEYAIAWSHTTFHLPKTTSFEEAATLPLAALTAAVSLYGHLELPAPWTPTETPTPFVIYGASTAVGSFAIKLARNSNIHPIIAIAGKGAPYVQGLLDPSKGDTVVDYRQGVAATIQAIKESLQKSGHSSARHALDTIASEDSAEVVRNSVAEGGKVDFVLPNELDVSPAVKTITSVGSVHNQPGFGTHENYEDLGQVFSRYFTRALQKGTFSAHPYEVRPRGLEGVEDALKDLKAGKASAVKYVFRIADTPGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTK2</accession>
    <name>A0A9W9WTK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786993.1">
        <property type="nucleotide sequence ID" value="XM_056937901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTK2"/>
    <dbReference type="GeneID" id="81628151"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051603">
        <property type="entry name" value="Zinc-ADH_QOR/CCCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154:SF1">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="15"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5475235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="337" mass="37369" checksum="C5B259B6C8ABE9B0" modified="2023-11-08" version="1">MVSKTMKAIGVAKYGAIDNLESRDVPRPERPTGMDMLIEHVAKACSVNPIDTKVRNGTYDDAPGTNSPPARKVWYSSITFVQDYYKYVPNDFHIIGFDGAGTVLEIGTECTNSKPGDDIFFVGSTTRQCSNAEYILVNKRLCAKKPKSLDFVEAASMGLTFGTTFQSLVHRLEIKQNENAGILIMGATHVVNHKADLESQIKALKLDVPIKYVYVVARTEQYIHAVRKICAPFAKVCSIVQAKFDLYGTEWMSKLMTFSWDWLGTSACHHTDTEKYQQVLANLTRYIEDGKLVPNLNRCLKLNLAGLKEAHRLIESATTVGKLSLGVDEASEGATFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTW4</accession>
    <name>A0A9W9WTW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008458</name>
        <name evidence="3" type="ORF">N7539_008464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTW4"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5475398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="144" mass="16417" checksum="034F850B4874838E" modified="2023-11-08" version="1">MPAEPRGRVWSQALPFQQFHVLFNSLFKVLFIFRSLYLCAIGLRPSCIPKQLDSSKELHTGADTPSQTGFSPSMTDRSRPLRWGLLPKHPLQITMRTPKEPAFKFELLPLHSPLLRQSLLVSFPPLIDMLKFSGYPYLIRGQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUE9</accession>
    <name>A0A9W9WUE9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein hob1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_007971</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787437.1">
        <property type="nucleotide sequence ID" value="XM_056937572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUE9"/>
    <dbReference type="GeneID" id="81627821"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000048">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000189">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="7">
        <location>
            <begin position="17"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="349"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5475684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="408" mass="46339" checksum="832105B755F1B511" modified="2023-11-08" version="1">MSFKGFQKSIVRAPQQIKAKFNIGEHTKDAVYTDAERRFDELERETKKLHDESKKYFDAINGMLSHQIEFSKAIAELYKPISGRASDPESFKFEGNPEGIQACEDYEAIVRELQESLAPELEMIESRIISPADQLLEVIKVIRKVAVKRDHKQLDYDRHRASLKKLQDKKDKSLKDEKALYKAENDVEQATQEFNYYNDLLKDELPRLFQLEAEFIRPLFQSFYYMQLNVFYTLHEKMQGMNISYFNLAMDVEEAFEQKRGDVQERAEALLIVHFKTKGLGRTNSKLNSLKATEAKGGRGRASSLSSENPPPPYSAAASPSPTAGTFSAAAKAKPAPPPPRAKPAHLSKPVETVVALYDYEAQAHGDLGFSAGDVIEIVTRTDNQNEWWTGRVDGREGQFPANYVKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUN4</accession>
    <name>A0A9W9WUN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcriptional regulator family: Histone-like TF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_007141</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CENP-W/WIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5476997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787541.1">
        <property type="nucleotide sequence ID" value="XM_056936742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUN4"/>
    <dbReference type="GeneID" id="81626991"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13732">
        <property type="entry name" value="HFD_CENP-W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000075">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052484">
        <property type="entry name" value="CENP-W/WIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34832">
        <property type="entry name" value="CENTROMERE PROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34832:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="9">
        <location>
            <begin position="9"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5476997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="78" mass="9003" checksum="2D1C44F71A6597CC" modified="2023-11-08" version="1">MVATQKLYPRGTVKRIVKAHSNRSVSKNADILIFLDYMLFMQELMREASIRSRKSGEKNISANSVRKVTEKTLRKFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVI2</accession>
    <name>A0A9W9WVI2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788048.1">
        <property type="nucleotide sequence ID" value="XM_056937249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVI2"/>
    <dbReference type="GeneID" id="81627498"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="80"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5477504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="346" mass="37828" checksum="300F473430D9129D" modified="2023-11-08" version="1" fragment="single">MMDDRLRKRVMLSRRPAPAAAPAPNACFSRYRAAKASVVRSRRMRQSSSSGSFRRLERRRPMAPPNVSSPARSPSSSPIVMLRVGPQQRLFAAHESILSACPIFAAQCSSQIPSPPPPSHPHITAPSKRIDLPDENAEVFSCVLEYLYKGDYTPRLQHNPTTGTWTLAPDAPAPQGTMVASVASATTNTSTNAVIWHHAAEGPVLRDTAVYCSALAYKLPSLARLALRKQGLQMGIPCRTILSSARFAYAHTPDTESRLRAHYLALMIRCRSTFKRSGTMQAEMEKGGRLFFDLFVAMCNHMVSLTSCSQSVVQLLEEVLLVGLGLVSKKANRNVPTGRCISVGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1J9</accession>
    <name>A0A9W9X1J9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788189.1">
        <property type="nucleotide sequence ID" value="XM_056936254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1J9"/>
    <dbReference type="GeneID" id="81626503"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5480759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="195" mass="22617" checksum="B7AB325DFCE07EEB" modified="2023-11-08" version="1">MSHEYDFVIFVARGSCNRRVSRQQAAEEFHALQTSLKYTKICYEDAYGPITGDWEFHEFLWPSTLELPEVSDTARFFAERTSKLEDTDKEMMIVLNGWDGLTAHKDSLSMLLRERASQITLRIFTDQPRAFYQVNVAQLFWLFDEMVRVDGEEEEKALGEKEHMGPLLSSIEAHLEYSTGLFYRHFTANRSASAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1Z3</accession>
    <name>A0A9W9X1Z3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1857-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788360.1">
        <property type="nucleotide sequence ID" value="XM_056936425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1Z3"/>
    <dbReference type="GeneID" id="81626674"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015075">
        <property type="entry name" value="AtaL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08982">
        <property type="entry name" value="AtaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5480930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="18922" checksum="A01DFCC5A196F7F6" modified="2023-11-08" version="1">MPSSSHNFAYTALVNPSDITLDLTNPHITASQLWDGLLAKARAAEGFVGGAILSTTVLDESINEDGNLVINREVVFSAMPDAKPVHEKVTAYEPSQVDFEQPNGSVISNVISEGLHGELYLTYVFRWMHPGLSAEEVKRVMEKEKMGAKTAVQATLVAVRKLVQEENAARKSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X214</accession>
    <name>A0A9W9X214_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_006601</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788137.1">
        <property type="nucleotide sequence ID" value="XM_056936202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X214"/>
    <dbReference type="GeneID" id="81626451"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000306">
        <property type="entry name" value="IKS protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000699">
        <property type="entry name" value="Probable serine/threonine-protein kinase iksA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF138">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE IKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="146"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="89"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="471"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5480707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="689" mass="76994" checksum="73232434A911F1C3" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2E4</accession>
    <name>A0A9W9X2E4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_007030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788566.1">
        <property type="nucleotide sequence ID" value="XM_056936631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2E4"/>
    <dbReference type="GeneID" id="81626880"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="82"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5481136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="259" mass="28215" checksum="D3260DF23DDFEE45" modified="2023-11-08" version="1">MADAAPRGRGGFGSRGDRGGDRGRGRRGRGRRGGKQEEKEWQPVTKLGRLVKAGKITSMEQIYLHSLPVKEYQIVDFFLPKLKDEVMKIKPVQKQTRAGQRTRFKAIVLIGDGEGHIGLGIKTSKEVATAIRAAITIAKLAVLPVRRGYWGTNLGEPHSLPVKQSGKCGSVAVRLIPAPRGTGLVASPAVKRLLQLAGVQDAYTSSSGSTKTLENTLKATFVAVVNTYGFLTPNLWKETKLIRSPLEEFGDVLRQGKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2X6</accession>
    <name>A0A9W9X2X6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ran-interacting protein Mog1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_006340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MOG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788866.1">
        <property type="nucleotide sequence ID" value="XM_056935942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2X6"/>
    <dbReference type="GeneID" id="81626191"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF0">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04603">
        <property type="entry name" value="Mog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="Mog1p/PsbP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5482894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="25793" checksum="D491443726F1718E" modified="2023-11-08" version="1">MAHITTKDFFGGAIRGIVPHRWIDGSDLREVPDHQELFLSPDTLSTFIIEINQRVSKEEALSTFATFTHQHPGLSTASSGTATAGTAETINQAAALYHLNDLCDEGDAMEIVTPPTRVVPTSLSASAPPGSSISAFEGIVQYLTTGRRRGTSGAVTDSAVAGASIDGPSGEGAKVSKVTCHYLLVRLEAQETDLLAFFNVPHKEFDEKGDAQGLSREEGVAESFMASLVDRLEIRDWGLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X594</accession>
    <name>A0A9W9X594_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789349.1">
        <property type="nucleotide sequence ID" value="XM_056935477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X594"/>
    <dbReference type="GeneID" id="81625726"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="349"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5484079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="909" mass="102148" checksum="81D02522D8BA8FFE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5H4</accession>
    <name>A0A9W9X5H4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Replication factor C subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_005927</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789401.1">
        <property type="nucleotide sequence ID" value="XM_056935529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5H4"/>
    <dbReference type="GeneID" id="81625778"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000030">
        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000002">
        <property type="entry name" value="Replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5484131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="353" mass="39876" checksum="49170F74C0699BDD" modified="2023-11-08" version="1">MALLVDKLRPRTLDALTYHPELSDRLQSLAQSGDFPHLLVYGPSGAGKKTRIIATLKELFGPGVEKIKIDARVFQTTSNRKLEFNIVSSVYHLEITPADVGNYDRVVVQELLKEVAQTQQVDLSAKQRFKVVVINEADHLTRDAQAALRRTMEKYSPNLRLILLANSTSNIIAPIRSRTLLVRVAAPSESDICSALRIAARREGWTEAPGLNKRIAKESGRNLRRALLMFESIYAQNEQVTDGTVIPPPDWEALISVTADDIVRERSPAQLLQVRARLYDLLTHCIPPTTILKTLTFMLVAKVDDVLKPDVIKWSAFYEHRIKLGSKVIFHLEAFVAKFMRIYESWTMGMDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5P0</accession>
    <name>A0A9W9X5P0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_005964</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789438.1">
        <property type="nucleotide sequence ID" value="XM_056935566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5P0"/>
    <dbReference type="GeneID" id="81625815"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040866769" description="Cytochrome b561 domain-containing protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="9">
        <location>
            <begin position="189"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5484168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="384" mass="42035" checksum="EF6F84E465D8825E" modified="2023-11-08" version="1">MPKRDFLALFSSFSWVLHTQAQYQGFAPFKHDELTYTIRVPESTAHSGDGPLYFQMNTSRPIEWFALGQGAAMHDSRMFVVYTSGDNVTLSPRAGKGHYEPLYDKTLRASLISGTGVHDGTLTANVRCDNCKLSPSRATNLNYAFSPWIWAIKFGASLGTLSLTAKIAEHDAFGVFYVNLTKATGPDNDNPLLNIDRRSITKAWTQPFDHNGFDRKRTAHAVLMTLAFVLFFPLAALTLHLLKSPQTVRIHASIQLFTLAMTVAGFGLGVSMAKDVHILKHHHAIVGFVVVCCLVLFQPLMGLLQHRHFKKSGGKGPFAYFHRWLGRAMIILGVINVGLGFELTGIGSSAVPRGAVIAYGTVAGVLGLMYIVVIVGKAARRGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X637</accession>
    <name>A0A9W9X637_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="6">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_004965</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5484977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_056934567.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="16"/>
            <end position="278"/>
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            <end position="308"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="375"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="293"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
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            <end position="361"/>
        </location>
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    <feature type="active site" description="Proton acceptor" evidence="7 10">
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        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="44"/>
            <end position="48"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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            <begin position="54"/>
            <end position="56"/>
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        <ligand>
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        </ligand>
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        <location>
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        </location>
        <ligand>
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        </ligand>
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        <location>
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        </ligand>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="375" mass="41520" checksum="C134AA39D430F403" modified="2023-11-08" version="1">MGNEESSMVDESAHPSVLEARTVQAVAKYIKEHNVNKIVLMVGAGISTSAGIPDFRSPDTGLYANLAFLDLEEPEDVFDISFFRENPKPFYALARELYPGRYRPTIAHCFVKLLHNKGLLLKHFTQNIDCLERQAGVPGDKIIEAHGSFATQRCIECKTPFPDNEMQKKVQAGEVPYCNDPQCNGLVKPDIVFFGEPLPSSFHDSRDLPGQADLCIVMGTSLSVQPFASLPQLCSPGVPRVLINMERIGGLGSRPDDVLLLGDCDAGVRKFAKAMGWEEELEALWEETNPDPQAREAENAPLPTRDERLREEVTRLTSDVDRTLQLTNAYEQRVRDHLGEPKSSQTVTMSSSSEGTESSEGLAHVFPHLAPESRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6N9</accession>
    <name>A0A9W9X6N9_9EURO</name>
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        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
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            <end position="218"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5484189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="230" mass="26071" checksum="1BACA6C471F06A9B" modified="2023-11-08" version="1">MAFQIQYAEEHDAPALARINILSFETQGLLQALFPGAETPALELHKANNYMKHLANRQMHVVKVTDPLTGELVGNARWQLPEAIWPRDQTPALSEKAQEIAQDPMRLAPRPRNEALLAGFRTMLEHHRKKYLGETDLLLDFLATTPSYQGRGVGSALLRWGTAKADEKQLRIYLEATEAGYPVYVKHGWKVVEEVFFDREQFGGHGRDRFILMMRDPKPLAQSATEPGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7F3</accession>
    <name>A0A9W9X7F3_9EURO</name>
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        <recommendedName>
            <fullName evidence="1">holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_005482</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
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        <property type="protein sequence ID" value="KAJ5485494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056935084.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81625333"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055066">
        <property type="entry name" value="AASDHPPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22624">
        <property type="entry name" value="AASDHPPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase N-terminal" evidence="5">
        <location>
            <begin position="35"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="4">
        <location>
            <begin position="142"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5485494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="380" mass="42054" checksum="AF5DB4204B9DC4DE" modified="2023-11-08" version="1">MFGTKAERVSHGLPTLVRWFIDSRKWEAEGLDLPLIDALSPTEQEAVKRYHFASDRRMSLASQLLKYLFVHHACGVPWDQIVLSRTPKPEGRPYYASKSHTQVEFNVSHQASLTILAGVIAPSQEQLARQASFGGAIPVPPRIGIDITCVNERRKPITTGSDYSEFISAFSSVFSPQEMGQIQEPFLTLRRARQLGLADAFPKDDEATMINYGLRIFFSHWALKEAYLKMTGEALLAEWLQELEFSNVIPPPVPATSPPQRSTAPGDWGTPYSDIKVSKHGKLIEGVRLQLEAFGTDYVIATAGQGCPVGPLYQDSTCSLVGEDIANESAGDRIPISTRLALGQPNPWNPGSEILDPWLPVQQVDIDRDIRSCAKGRCSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7M7</accession>
    <name>A0A9W9X7M7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790355.1">
        <property type="nucleotide sequence ID" value="XM_056935161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X7M7"/>
    <dbReference type="GeneID" id="81625410"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF1">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE EPSILON SUBUNIT HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="329" mass="37750" checksum="F4D8CCF22320FE14" modified="2023-11-08" version="1">MDAQRQFPDVHWIWAGGISFAYEVHPRIVVKVAKSGEFERGQFRKELKVYEIFSQHTPCLSVVQCFFYSDNGITLESMRGGILTGSYRPTYYLKMVTKVEKLELLALRREWMNDLARAVALLESLNLAHGDLQPENILLDRDRVKLSDFDCTAEIGTDFEACMAPYGRILNVNETDQGGRGTPSSVGPRTEQFALGSLYNLINYGFEVYGDRRLTEDPREHGPKVVDLLQDMEYPKLNGDPLIDDITDKCWHNKYATVAELAAHTKRFLVEGTNSESTFVRWRTAIGRIVQEFWCGLENWLTLVRPSTINQDGSKLRLGQWQRAKWRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XC41</accession>
    <name>A0A9W9XC41_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division control protein 48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003545</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790688.1">
        <property type="nucleotide sequence ID" value="XM_056933147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XC41"/>
    <dbReference type="GeneID" id="81623396"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="43"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="143"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="255"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="529"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5488655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="820" mass="90194" checksum="5155B7F33A43D988" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCS6</accession>
    <name>A0A9W9XCS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable quinone oxidoreductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NADPH:quinone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_003787</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790930.1">
        <property type="nucleotide sequence ID" value="XM_056933389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCS6"/>
    <dbReference type="GeneID" id="81623638"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000053">
        <property type="entry name" value="Quinone oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="16"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5488897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="330" mass="35760" checksum="1C8E8F1063967D1F" modified="2023-11-08" version="1">MSVPSTMKAVVIEQTGGPEVLQYKTEHPVPTPKEGQLLVRNHISGVNYIDTYFRTGLYPSPKPEVLGREGAGTVAALGPNTSGFQVGDRVAWLATAGYAEYTAVPADKTIKIPDGIRDEDLVAAFLSGLTVLTLVKETYAVQKGDWVLLHAAAGGAGFLMTQVLKSMGAKVIGTAGGAEKCALVKSLGADVVIDYRSDEGRDWVQLVKEATGGRGVDVVYDSVGKDTWEGSLEVVKRKGTVVWFGNASGPVPPLPLQKLSPKCVKVARPMLFGYIETREEFEFYTHELFNLLKSGQLKVKIHKVYPMEDIKQVHEDLEGRKTMGKSLVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCU7</accession>
    <name>A0A9W9XCU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790869.1">
        <property type="nucleotide sequence ID" value="XM_056933328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCU7"/>
    <dbReference type="GeneID" id="81623577"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF10">
        <property type="entry name" value="SIGMA-70 REGION 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5488836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="388" mass="43981" checksum="C2EFA2E97F8BD977" modified="2023-11-08" version="1">MQPPYANSFVHETGSSWAGSSGTLHDSSWGGHFSTPLIIQNREDIELTDWWINKLAYWSGQNPYVKTQIYRTAMDHPFSFQAVILVYAARWRAQITGQSNSEEVQRHVGQVRKNIEDAVSGAIQVHDDQLATALAGMALAEGRYGSRQDAEAYLEHAARILSRRPGASSGVEVFFHYVRYILPPLSDMVSPTNRRLLVLFLQRAQELMHRHSSPGHQPQSSHGRTAFQMGSPLFSLLSSGPRPTQVPQEAHVYVVRTAETQEASRSGCLIYITAALWDFKDSVNKTHRFLAYLTALVEEHQLGKHPACETLLWLLLEQTCDADLRDPKRAWSTGQLLQAQRQLRPDLQFHYNELLMSFLSLQMPVRGIDVFQNELESSFGERRHSPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCZ6</accession>
    <name>A0A9W9XCZ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA decay factor PAT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_004034</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791177.1">
        <property type="nucleotide sequence ID" value="XM_056933636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCZ6"/>
    <dbReference type="GeneID" id="81623885"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019167">
        <property type="entry name" value="PAT1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF0">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09770">
        <property type="entry name" value="PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="289"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5489144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="822" mass="90357" checksum="72E9C9AE72213706" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XD79</accession>
    <name>A0A9W9XD79_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_003477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790620.1">
        <property type="nucleotide sequence ID" value="XM_056933079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XD79"/>
    <dbReference type="GeneID" id="81623328"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF32">
        <property type="entry name" value="SULFATASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G17610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="3">
        <location>
            <begin position="445"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5488587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="865" mass="98499" checksum="2E3F137631F002A9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDI7</accession>
    <name>A0A9W9XDI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_004192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791335.1">
        <property type="nucleotide sequence ID" value="XM_056933794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDI7"/>
    <dbReference type="GeneID" id="81624043"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13768">
        <property type="entry name" value="DSS1_Sem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5489302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="96" mass="11103" checksum="A766484148D21895" modified="2023-11-08" version="1">MSNSNQAQTNAEVAEQPQQQPKPQVLEEDDEFEDFPVEDWPQEEAEQNAGSAANGGNEHLWEESWDDDDAAEDFSKQLRYVMHRQQMSFEEWSRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDS0</accession>
    <name>A0A9W9XDS0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Solid-state culture-specific protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791455.1">
        <property type="nucleotide sequence ID" value="XM_056933914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDS0"/>
    <dbReference type="GeneID" id="81624163"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053269">
        <property type="entry name" value="Asp-Met_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003806">
        <property type="entry name" value="ATP-grasp_PylC-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37018">
        <property type="entry name" value="CULTURE SPECIFIC PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37018:SF1">
        <property type="entry name" value="CULTURE SPECIFIC PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02655">
        <property type="entry name" value="ATP-grasp_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="169"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="468" mass="51894" checksum="89D9721BC2CCA189" modified="2023-11-08" version="1">MSAPGSVVLDYTLHDLYNADDQDYDICMVNAYAPPPSIPLAAHIPAIKQFPVQAPLCPAYDQDELTRTILHLVAQRFAFCAGPMRILVLESESQKSQCSSHGRSQADISKVFSQLQEKQRPLPLFVPISDLSKFRLDAKTKLAVTGPLDWFSHIPQVIDPRIHYNLLSKRGLAKSGLPTPRTIVIDTVLSPSPTEPFTDKDLQPEIARMTKPILETPIPFIVKVPRITGVGQGTFIVHTEADRSSVYEVFLEEVKLMLLALNPANECLATCNVIIQEMVPGETASLNFFVTQTGRAIFNCCNHQDVDDAYIWSGGLVSYNEQAVLESQYRETMDAVAHFLHKHGYYGPAGVDIMTDETGVQFVVDLNVRITATYHLGPLRGHFTRRGFSEAAAMSTFRLTCTQAEFESHFAEELCSGSLVLTAWVHLQEASLVTMTVAARDRTGLQEIVQKVSEFADNFASTDHSYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDV1</accession>
    <name>A0A9W9XDV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791549.1">
        <property type="nucleotide sequence ID" value="XM_056934008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDV1"/>
    <dbReference type="GeneID" id="81624257"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="83" mass="9015" checksum="6AB31E8618804FB7" modified="2023-11-08" version="1">MGSRYPCPFGRESAVPKSGGRIASLRASARSSEETTGRLLTRVRFAESASEVHPYSTATPPRKTVQLADNNDNDLPSQPVRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDZ1</accession>
    <name>A0A9W9XDZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 15">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">N7539_004003</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791146.1">
        <property type="nucleotide sequence ID" value="XM_056933605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDZ1"/>
    <dbReference type="GeneID" id="81623854"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="13" id="KW-0779">Telomere</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="113"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ5489113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="473" mass="55407" checksum="5232B04505E28DBB" modified="2023-11-08" version="1">MDKYRYETPDAWKRGFCLSVRDLVDPESKLAQKYPHLCQIFRHRLETAYSERQFKPVSLCAHTDYENGYQGSRSDSDHFQRTEWFRQLQKADWMKDDTRNRMEHICPDVSKRMDFYGIAGEGTFGSVFLAREHNEEAADPNHLEHYAVKVTKHETLIGGLHDGLWEAPNGVVPDTRAPPTYIPSEALVMFFLTDSDRFPKLDSVYTHDRFQAIVMSPCVDYSSERQPVPSGDYDRQFPGFTARYLLTKDRKPLLSVNQACKVSAQLLEAMRHLADMNIWHNDISVNNILVDKNLNAQMIDLGEFAFGLEEQDFLQAGFRSVPFQEYQMFPELALSEEKDNGICRSDLHDLREECMWKFGTIIYGILHGHWPWDEAPKNGEPHRDLLDPDVYYDKSHIYHRRNRILNEPLPIDENLPQDCKVVLQSMFSKDPAERPSLAELEGYPWFAQWARETQVFERPFSKEFRSTYTQRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEG3</accession>
    <name>A0A9W9XEG3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="14">3.2.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">1,4-beta-D-xylan xylohydrolase xlnD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Beta-xylosidase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Beta-xylosidase xlnD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Xylobiase xlnD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">N7539_002312</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Xylan 1,4-beta-xylosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="14"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791874.1">
        <property type="nucleotide sequence ID" value="XM_056931915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEG3"/>
    <dbReference type="GeneID" id="81622164"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001420">
        <property type="entry name" value="Exo-1,4-beta-xylosidase xlnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000007">
        <property type="entry name" value="Exo-1,4-beta-xylosidase xlnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF13">
        <property type="entry name" value="EXO-1,4-BETA-XYLOSIDASE XLND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040828571" description="xylan 1,4-beta-xylosidase" evidence="19">
        <location>
            <begin position="21"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="20">
        <location>
            <begin position="696"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ5490745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="795" mass="86256" checksum="6E590664E26CDFB1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEG9</accession>
    <name>A0A9W9XEG9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791899.1">
        <property type="nucleotide sequence ID" value="XM_056931940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEG9"/>
    <dbReference type="GeneID" id="81622189"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5490770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="99" mass="10950" checksum="9AA3F31A2FB33C8D" modified="2023-11-08" version="1">MLFFLSSSEPECDQSKDEKIWHAPADPATGQRDQRDHCGYTNSGAKQPLARSNPIAQSASSEKAQSVQQIDEQERSKAECEGGNNITKIPRLAMEQTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEJ8</accession>
    <name>A0A9W9XEJ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="3 15">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_002372</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3 15"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791934.1">
        <property type="nucleotide sequence ID" value="XM_056931975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEJ8"/>
    <dbReference type="GeneID" id="81622224"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07856">
        <property type="entry name" value="STKc_Sty1_Hog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000050">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038783">
        <property type="entry name" value="MAPK_Sty1/HOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5490805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="368" mass="42138" checksum="E871C77694604CD0" modified="2023-11-08" version="1">MAEFVRSQIFGTTFEITSRYTDLQPVGMGAFGLVCSARDQLTGQPVAVKKIMKPFSTPVLSKRTYRELKLLKHLRHENIISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVVHRDLKPSNILINENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDDVIQTICSENTLRFVKSLPKRERQPLENKFRNADADAVDLLERMLVFDPRKRIRADEALAHPYLAPYHDPTDEPVAQEKFDWSFNDADLPVDTWKIMMYSEILDFHNIDQANEAGQALVAGASHSGMAPQTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF21</accession>
    <name>A0A9W9XF21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_004573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791716.1">
        <property type="nucleotide sequence ID" value="XM_056934175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF21"/>
    <dbReference type="GeneID" id="81624424"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5489683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17978" checksum="1D4450B6D037A209" modified="2023-11-08" version="1">MPRHSELSPITRTKICALRNHANFSYNKIAKTFPDIPRTTIIRTCQQEAVRGKDNKSLPRTGRPKILTPGDHDLIRAYMRQRPNCRYEELVDLVGKKISCCTMSKMVLLEYMHDVTFVCCTILRKKGIEVILVLRLVMNEMNDEFGVGIRGPIVSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF51</accession>
    <name>A0A9W9XF51_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Meiotic recombination protein rec14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_004482</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791625.1">
        <property type="nucleotide sequence ID" value="XM_056934084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF51"/>
    <dbReference type="GeneID" id="81624333"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="186"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="228"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5489592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="310" mass="32736" checksum="025E2ED0061C428B" modified="2023-11-08" version="1">MSRQYLAWGSADNAHPVDIFSLAVTEKQVLSVSGAPSIKVHSTENTEFPLVQSIDQAHTLGCHHIVTDSSGTRAVSAGFDGNLKVWACNDGHWAADATTTASLASIHPWAIALSGDGQYLAGVSESGHVGVWDLNNEGAQIRDHETKGSFGTCIDLSADGRFIASGHENGAVYIFLTDTGRMPFSLSGLVKPVRAVAFSPGGKILAAAGDSKVIVLYDTSSGEQIANLSGHSAWVLSLSWSSSGEFLLSSSFDGKVKVWSIDTKMCVATHSETEKAVWSVKWLPKTARSESFATAGANRSVAFYREATGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF85</accession>
    <name>A0A9W9XF85_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spermatogenesis-associated protein 20-like TRX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792313.1">
        <property type="nucleotide sequence ID" value="XM_056932354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF85"/>
    <dbReference type="GeneID" id="81622603"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="Ssp411-like_TRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spermatogenesis-associated protein 20-like TRX" evidence="2">
        <location>
            <begin position="19"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="681"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5491184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="784" mass="87463" checksum="51456B5666CC6407" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFA7</accession>
    <name>A0A9W9XFA7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_002669</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792231.1">
        <property type="nucleotide sequence ID" value="XM_056932272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFA7"/>
    <dbReference type="GeneID" id="81622521"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="30"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5491102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="526" mass="58308" checksum="E3A3EEC4385A2115" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFJ2</accession>
    <name>A0A9W9XFJ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792459.1">
        <property type="nucleotide sequence ID" value="XM_056932500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFJ2"/>
    <dbReference type="GeneID" id="81622749"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076:SF1">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076">
        <property type="entry name" value="CYANOVIRIN-N HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanovirin-N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="123" mass="13556" checksum="FB2E9BDA43903A1C" modified="2023-11-08" version="1">MGFHKSSLNVKLKDGHMLSAYCQRPTGEAVYSELDLNEFLGVRKGEHLDSSSSGKLTWSGHNFTQAAENIHLEWEGDSKPQNPILHADVYTDPAVGAESSASCVNLADCIKNEDGHLRFMDCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFJ3</accession>
    <name>A0A9W9XFJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_002390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Involved in mitophagy. Required for the switch to necrotrophic growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa. Interacts with ATG24/SNX4; the interaction is direct and plays a role in mitophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791952.1">
        <property type="nucleotide sequence ID" value="XM_056931993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFJ3"/>
    <dbReference type="GeneID" id="81622242"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035632">
        <property type="term" value="C:mitochondrial prohibitin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="25"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00053189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5490823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="279" mass="30734" checksum="F9ACAE02DE999DBD" modified="2023-11-08" version="1">MANALYNIYRLAGPVAAGAILFNASIYDVRGGTRAVIFDRISGVQETVVNEGTHFLIPWLQRAIVYDVRTKPRNISTTTGSKDLQMVSLTLRVLHRPDVPKLPQIYQSYGTDYDERVLPSIGNEVLKAIVAQFDAAELITQREAVSNRIRNDLLKRASQFNIALEDVSITHMTFGKEFTRAVEQKQIAQQDAERARFIVERAEQERQANVIRAEGEAESAEIISKAVAKAGSGLIEIRKIDASKEIAHTLATNPNVTYLPGGEGKDGGKSTSLLLGLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFQ4</accession>
    <name>A0A9W9XFQ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_002997</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792559.1">
        <property type="nucleotide sequence ID" value="XM_056932600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFQ4"/>
    <dbReference type="GeneID" id="81622849"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000547">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016314">
        <property type="entry name" value="Cdc6/18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001767">
        <property type="entry name" value="Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="207"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5491430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="642" mass="69984" checksum="8BD48ED264AC2369" modified="2023-11-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG25</accession>
    <name>A0A9W9XG25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_003177</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792738.1">
        <property type="nucleotide sequence ID" value="XM_056932779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG25"/>
    <dbReference type="GeneID" id="81623028"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="308"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="338"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="396"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="75"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="170"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="257"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="460"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="572"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="174"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="478"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5491610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="629" mass="68924" checksum="9C9EAE6CB3B3F908" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG29</accession>
    <name>A0A9W9XG29_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translocase of outer membrane 40 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_003182</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Channel-forming protein essential for import of protein precursors into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792743.1">
        <property type="nucleotide sequence ID" value="XM_056932784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG29"/>
    <dbReference type="GeneID" id="81623033"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000009">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-0626">Porin</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5491615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="354" mass="38185" checksum="B3DE9C1F036E6227" modified="2023-11-08" version="1">MGDLTSSLSVLTENPAMAIVNDMYTSFAERRALLNLPNPGTVDNIAREVQKEVLLSNFMFSGLRADLTKVFGMSPLFRVSHAFSMGGSGNLPPYAFSSMYGSPKVFMQGNLGSDGTLSAVYNWRWNQALVTKTNAQIMPGGGQGLMQIDNDYTGKDFSASLKAFNPSFLEGGLTGIFVGSYLQSVTPGLALGFEAIWQRQGLNARPETALSYCAKYKGDDWIGTAQLQAQGTFAATYWRKLSERVEAGVDMNLQFAPNAAAMMMGGPSRDGTTAIGAKYDFRASSFRAQVDSAGKVSCLLEKRIAMPISLTFAGEIDQAKQTAKVGLAVSLEIAGEELMEQQEKADPNMMPPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG78</accession>
    <name>A0A9W9XG78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_003242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792803.1">
        <property type="nucleotide sequence ID" value="XM_056932844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG78"/>
    <dbReference type="GeneID" id="81623093"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="153"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5491675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="411" mass="47113" checksum="102420D1C531B118" modified="2023-11-08" version="1">MDSRRNPSLVVGDSQESPRGGDITALTVQRCSAEYSGDEDQGYATFDHFLWHESAETEELQLMKRSSDRHTPTASSNIPKEDWVQTPEAQETFEVTKATEAFERITAKQDDEQWESYLYPSFGKPSQIKFRKAVIDAYDSFTCTDGLWPELWCPVLGKYLQDKKVIASYLFSWRYGQETMDAIFGEAAKSELFSPHNGILMSYAVKAAFDIGKLAIVPCDLKETGWTTIQGIRNWLSRGPDEYQVKILDQKWDGLDEELEGHPSLTFRDLDGRKLQFRNSFRPAARYMYFHYCIQVVRYAWQHNEVNGPAEAAEMLRNEHGQSYWGTSGKYLPKNMLQSVIQEIGHEYKSLLDRACPSTGNSDLLLELAAVQVITLHVLDPRPLEDAWLTLRRRVPTLENIDEFTTDSEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGG2</accession>
    <name>A0A9W9XGG2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_003316</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792877.1">
        <property type="nucleotide sequence ID" value="XM_056932918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGG2"/>
    <dbReference type="GeneID" id="81623167"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000213">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041015896" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="9">
        <location>
            <begin position="48"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5491749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="566" mass="61445" checksum="D0CD93F9EEDCFE7D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGG3</accession>
    <name>A0A9W9XGG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792938.1">
        <property type="nucleotide sequence ID" value="XM_056930907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGG3"/>
    <dbReference type="GeneID" id="81621156"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="266" mass="30064" checksum="B5BFB75B1D11DB5F" modified="2023-11-08" version="1">MEKSEGLSIQKLLLIVITYLLLRYHTRPGTWLHRHVISSTIFILITTPLSQLTDMVLRIMSPCISHGCESVWMRTLIWLRELVGISNTFSDDPIQFLINLVLIFISGLFVLLLPLLFLLIAMTILAFGTWPVLIVFGAAIVTLLMPRHTPTILAAQAEDKVLARPTQSPRSADSELLQTIRTVTRSSVFRETIQITLELDLLPDGVNRIIQYFQEPAGFRAGAKKDLVRMMKCQIIGYVRDYEQIAVVPVAIFLGAKDILIRILEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGW8</accession>
    <name>A0A9W9XGW8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA recognition motif-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793193.1">
        <property type="nucleotide sequence ID" value="XM_056931162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGW8"/>
    <dbReference type="GeneID" id="81621411"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="53040" checksum="A355A2AA46BD2286" modified="2023-11-08" version="1">MPPQPGEERLLTVFADIHYYFTAPTAKPSDHRFEKGSYLYIYYDPSTRKARIEVANNPGTPEQDAFHGSLDSVHIQHASHFPTRCSLTVEGVSGSVQQQTSHYDWRLPGIEPRNAPSDLPRIHTVDIYFWTLADANEFLDVVERILLPAQLMTDRPNAQMDQPISPVVQQLENIAVSDPAYQNGQTPNSRSDHPVRASQVTQPLSMTPSFPPPPPGEPSNGQANPGTTQPLHGEQRNSANFAPLPYNPAAPAAPEPIQHRDKTPPPEDGANGTGLAAAMAADHGVSYAPSHQTVINQGNNSFAPPPISASAMQYPGFSATGPTGYVSPPPSVGLTHSNSFSSQPSMHTTDPRSGFIQQHSRGQAWQNSAVQGTTSFAPPPQEPNAHLYSQGIQGGPQSPHQHPGQATPLPGYVEYSYGQSSVSRPVSSEYDIHNQLYRPTEAEASGHGQKYAKKAMKSPERPRKLEDKAFKAESGVNRFLKKLERKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGX5</accession>
    <name>A0A9W9XGX5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cobalamin-independent methionine synthase MetE C-terminal/archaeal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793202.1">
        <property type="nucleotide sequence ID" value="XM_056931171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGX5"/>
    <dbReference type="GeneID" id="81621420"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844:SF2">
        <property type="entry name" value="SYNTHASE, VITAMIN-B12 INDEPENDENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="1">
        <location>
            <begin position="179"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="402" mass="45669" checksum="4883E4051D19C913" modified="2023-11-08" version="1">MAPHLHQRPPFRAEHLGSLLRPQNLLEKKTASEKGEIPESALKTVEDREVQNIVATQLKLGYHAVSDGEYRRHMFWGTFFPGLDGFEEVTEFDVDIFRPYAPDIAAFLESGHKPGETVLCTGKIKHVGSTYVDQFKYLASLVPQADVKNLKITLAAPNWYHLRYREGKSYPKDVYANDEEYFGDIAKAYQTELKILYDAGCRNVQYDDPNLAYFCSEKFLTGFKEDAGNVYSADDLFQKYIKLYNDCFIGLPEDMHVGVHLCRGNFVGSRHFSEGGYDRIAIKLFQELNVHTYYLEYDTPRAGGFEPLKYLPTRKNVILGVVTSKFAKLEDKEEMKKRVIEAAKFIAEGNNVSLETALNQVGVSPQCGFASHREGNAIDHDGMINKLRLVREIADDLWPGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGZ7</accession>
    <name>A0A9W9XGZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_001434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793068.1">
        <property type="nucleotide sequence ID" value="XM_056931037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGZ7"/>
    <dbReference type="GeneID" id="81621286"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5492688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="63" mass="7046" checksum="27E9D23177AC7B78" modified="2023-11-08" version="1">MARLNSYLYRINVAETDYNTHRGNLSFFLGGKSPSDSQQWIPNLEAVRASIRFAIATGRLDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH01</accession>
    <name>A0A9W9XH01_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable acetate kinase</fullName>
            <ecNumber evidence="5">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_001604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793238.1">
        <property type="nucleotide sequence ID" value="XM_056931207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH01"/>
    <dbReference type="GeneID" id="81621456"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="ACETATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF15">
        <property type="entry name" value="ACETATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="212"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5492858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="414" mass="45459" checksum="DFC31EE4E535A513" modified="2023-11-08" version="1">MGKYILAVNAGSSSVKVTFYTCDNPPRAIADAQVSGITAPPPTFKYQHGETKVKEELKDKLNTPQDAFKYIVERCFKDSELSEVASERDVAYICHRIVHGGEYHEAVEINDDTLHHLEKLEDLAPLHNFSALEIVRFCKKELPSVKSITCFDSAFHQTLPDYVKTYPINQQIAKANGLRKYGFHGISYSFIVRSVAQFLGKPQEQTNIIAMHIGSGASMCAIKEGKSVDTTMGLTPLSGLPGATRSGDIDPSLVFHYTSEAGKLSPASTKEMHISTAEEILNKQSGWKALTGTTDFAQIAVDKFPSEAHKLAFDIVIDRMLGYIGNYYLKLGGKVDALVFAGGIGEKSALLRRTLVEKSQCLGFAIDAKANEDGPRDDEVVKDISQSSSQGPRVVVCQTNEQFEMAYTTIQSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHA8</accession>
    <name>A0A9W9XHA8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S10, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial ribosomal small subunit protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_003169</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792730.1">
        <property type="nucleotide sequence ID" value="XM_056932771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHA8"/>
    <dbReference type="GeneID" id="81623020"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000003">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="8">
        <location>
            <begin position="143"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00078476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5491602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="298" mass="33645" checksum="878174BC09BA8CC1" modified="2023-11-08" version="1">MFLGTTRSLVGASKRLWTPISIRSLSTPNQPSAPSTKTSTTAPQIKAEPTPTSATSPTSATPMPVKESAAFEKPPVKEWLVELWRSLTTLFNVLVLIIFLFLEYSRSDRLADLEKNARLPRSVQALYLRPLRRKAEHGLPVCDLQLRSYSAENLEFFADFAIRAAYYLKLPVSGPVPLPRITQRWTVIRSNFVHKKSKENFERITLRRLIQIKDGHPEAVQAWLAFLRKHAFYGVGMKANVWEHESLDAGKALDASLPEIQKTVGPHLAQFGQREDNKRPGTIFDALDNARYAEPKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHH1</accession>
    <name>A0A9W9XHH1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitogen-activated protein kinase kinae kinase bck1</fullName>
            <ecNumber evidence="2">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_001853</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793487.1">
        <property type="nucleotide sequence ID" value="XM_056931456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHH1"/>
    <dbReference type="GeneID" id="81621705"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06629">
        <property type="entry name" value="STKc_Bck1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000182">
        <property type="entry name" value="MAP kinase kinase kinase mkh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF48">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BCK1_SLK1_SSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="858"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="314"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="412"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="473"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="545"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="702"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="728"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="825"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="552"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="733"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="793"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="838"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="887"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5493107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1149" mass="124883" checksum="266A3017C163CA32" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHZ7</accession>
    <name>A0A9W9XHZ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_002097</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Lipid-anchor</topology>
            <topology evidence="1 10">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793731.1">
        <property type="nucleotide sequence ID" value="XM_056931700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHZ7"/>
    <dbReference type="GeneID" id="81621949"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000032">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF5">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041013144" description="1,3-beta-glucanosyltransferase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="330"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="387"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="394"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5493351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="467" mass="49523" checksum="4F4B853AB420C422" modified="2023-11-08" version="1">MKGAISSVAVALSLGAQFVLAAPSDVAKRGSGVTPITVKGNAFFKGNERFYIRGVDYQPGGSSKLADPIADAESCKRDIKNFQDLGLNTIRVYSVDNSANHDECMKALADAGIYLVLDVNTPKYSLNRANPAPSYNDVYLQYIFATVDMFSRYDNTLAFFSGNEVINDGPSSVAAPYVKAVTRDLRNYLKEQKLRQVPVGYSAADVDTNRLEMAEYMNCGTADERSDFFAFNDYSWCDPSSFTTSGWDQKVKNFTGYGIPLFLSEYGCNTNKRQFQEVAALYSTKMTGVYSGGLVYEYSEEDSNYGLVTIKGSDVTPLPDYKALKSALDKTANPQGDGNYNKTGGANPCPKKNSPNWDVDSTGSLPTIPKPAEKYLKDGAGKGVGFSGKGSQWAGTASSSNSTGNGSSSSGSSSGSSSASTTSGAAGQTSSAAASGLVKPFTVSMAPVAVSLVTIVSTLFGASFILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIH9</accession>
    <name>A0A9W9XIH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAR-17a/AIG1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_002229</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793863.1">
        <property type="nucleotide sequence ID" value="XM_056931832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIH9"/>
    <dbReference type="GeneID" id="81622081"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF16">
        <property type="entry name" value="AT02829P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5493483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="27444" checksum="586B025C7D4A256E" modified="2023-11-08" version="1">MGASNFFQHPLQRLPSPSRGLSAFIHISGLASFIWSFKYMHENPNRANEAYGWHFQYLTVIGLTLSTVTFLVALLADLTLSRRLFLIKNLLLICSAPMEVLISVLYWGLRLIDERLVVPDWAVIPLHADLGFHAVPSIVMLLDLLFFSPPWTISALPSLGLSSAIAFGYWVWIERCFLYNGWYPYPIFEQLSTTGRAGLFSLSAVVMAMSTVTLKWLYGRINGFGTPFPAQSRPGDIRKNERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIK2</accession>
    <name>A0A9W9XIK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor TFIIIC complex subunit Tfc6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_001936</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793570.1">
        <property type="nucleotide sequence ID" value="XM_056931539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIK2"/>
    <dbReference type="GeneID" id="81621788"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5493190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="750" mass="83791" checksum="604BF072D9BCDA66" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIN2</accession>
    <name>A0A9W9XIN2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spliceosomal protein DIB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_001815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DIM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793449.1">
        <property type="nucleotide sequence ID" value="XM_056931418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIN2"/>
    <dbReference type="GeneID" id="81621667"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5493069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="143" mass="16951" checksum="AACE739F7F68D67D" modified="2023-11-08" version="1">MGSIVLPHLRTAWHVDQAILSEEERLVVIRFGRDHDPDCIRQDEVLYKIAERVKNFAVIYLCDIDEVPDFNSMYELYDTMTIMFFYRNKHMMCDFGTGNNNKLNWVLEDKQELIDIIETIYKGAKKGRGLVVSPKDYSTRYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM83</accession>
    <name>A0A9W9XM83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794552.1">
        <property type="nucleotide sequence ID" value="XM_056930259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XM83"/>
    <dbReference type="GeneID" id="81620508"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="151" mass="16193" checksum="16881FCD39EFD2C0" modified="2023-11-08" version="1">MSHQSRWRGPSRQSSQRQPGNGNRHQGGGRGGNSSWNANVSAGNAHASAQDQHVPVRGFNAMEAKNVLKEGKHEFYCASRCCPTRETDSRPTFYKPSAKDIAAQKSSNSPWGSKPNLMANGKDFWLELRKQVTALQRGGSGSGSSGPPVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN86</accession>
    <name>A0A9W9XN86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795129.1">
        <property type="nucleotide sequence ID" value="XM_056930836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN86"/>
    <dbReference type="GeneID" id="81621085"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000069">
        <property type="entry name" value="HAD-superfamily subfamily IIA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF51">
        <property type="entry name" value="HYPOTHETICAL HAD-SUPERFAMILY HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5496116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="479" mass="52591" checksum="A303B1E1B90ACCF0" modified="2023-11-08" version="1">MPHYDEEESTAELVAPDVPLASHSGLSPRAAALPIPSHADNTISIPASRSSMGDAGSLMHNLSLSPSTKARRGSRNSFGTSLPIPRSPRRSRASLQRAAPAVSRDILASQVQDMAKEKVANAKNMAFVFDIDGVLAHGNEPIEPAKEALKMLNGDNELGIKIPYILLTNGGGKPEVARCEQLSEILEVPISTDQFIQSHTPMQALAEYYETVLVCGGEGVQAREVAQTYGFKNPVHPKDILAWDPSASPWRVFSDADRAMTKPQDFSQIKFDAILVFADSRDYATDMQLILDLLLAEDGKLLTRAQDPVSSRIPIYFSQGDLVFPTEHKGPPRLTQGAFRIAIEAQYKALTGVELERVVYGKPERATYTYADEVLRSWMEQIHNENKLPQNIYMIGDNPQSDIVGGNMYGWNTCLVRTGVFQGKDGENDKNNPASFGVFDNVLEAVKAAVRRELGQEFKLKWNPKVNPILSGDDDSAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XNK8</accession>
    <name>A0A9W9XNK8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome monooxygenase FUM15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794883.1">
        <property type="nucleotide sequence ID" value="XM_056930590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XNK8"/>
    <dbReference type="GeneID" id="81620839"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000051">
        <property type="entry name" value="Cytochrome P450 monooxygenase (Fum15)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF227">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="596" mass="65972" checksum="806EAD06F296EC5F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XP63</accession>
    <name>A0A9W9XP63_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_000945</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794842.1">
        <property type="nucleotide sequence ID" value="XM_056930549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XP63"/>
    <dbReference type="GeneID" id="81620798"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5495829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="804" mass="90219" checksum="7D290F7D71E92F21" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJK1</accession>
    <name>A0A9X0BJK1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mediator complex subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_009172</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786144.1">
        <property type="nucleotide sequence ID" value="XM_056938767.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81629017"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057344">
        <property type="entry name" value="ARM_SRB8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25326">
        <property type="entry name" value="ARM_SRB8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="13">
        <location>
            <begin position="277"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="130"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1482"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1482"/>
            <end position="1518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5469554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1575" mass="173884" checksum="924ECD5CBC1666DC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BLT2</accession>
    <name>A0A9X0BLT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquinol-cytochrome-c reductase cytochrome c1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786632.1">
        <property type="nucleotide sequence ID" value="XM_056938250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BLT2"/>
    <dbReference type="GeneID" id="81628500"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="264"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5472086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="42700" checksum="72798A30188E5488" modified="2023-11-08" version="1">MSQSDPDERLIFLACQHIFRGPNFQVRKFKTVKGLIRQNELSLTDILREYDIDRTSSVAKKLLESQVFDSTLKAKIRFPELFDVSPTQSAEREASEAEAAREEANTVREISDCEASKDTAISSLTEVGSERTFSGDQLIPASCPEQDTDTIIAIPSLYPVYIHYRCQHLVLTTIQELLEESCFEFAQQHFPLLLATNEWDCPEAVELTEWTKILSRQYNPPFNDLKTPVNKFLGLLRELRHSAVHRLRKTAAAFLNALEDSTRSEKVETLRRELQTAIEELKRNKDLFEKRLVAQLKEIQKKRSELDIWEKNTREGMIREDLQCSRDIGEVLESVVRRVKSKDPKEAEGAKSVPDVYSDSLDSEDEFLDVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BLZ8</accession>
    <name>A0A9X0BLZ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786469.1">
        <property type="nucleotide sequence ID" value="XM_056938087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BLZ8"/>
    <dbReference type="GeneID" id="81628337"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5471923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="383" mass="44402" checksum="F7ABCF928E15452B" modified="2023-11-08" version="1">MTPIPGSPRSDLCVKAVRDDQAWVLVPKRLFIECFPDDFIHNYAHWYAIDGGYIEIRPLLSPWVSSEHHWRLRKVDWENSWRLENREHYLVGSRSRTANTLAGILNPLEKPPEIHGRLDKVKFTLYIDLPRLRLEFVVPERSTTVQCRQYPGMIIDAKQACNALAGDHVRVNVRCEAQWHAYSIDERLGRFVDNGSLQSKLFLAYLYAITSYFLPDPLTRRTGTEQALSILRSASVRSFDRLRPENVAILTRIATLTPQRRFYPDNEQVMQSVEWRHALSCLSQHPGFYEEVAAIRDQNLRVTFYYPGEEPAMPSLPGVNQHLLLRDKIRTSSFRVSQFGSEDHTGKHDRPYASRDAYRCSPNSTRAFTISKMLVARYPVREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BM17</accession>
    <name>A0A9X0BM17_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease H1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786529.1">
        <property type="nucleotide sequence ID" value="XM_056938147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BM17"/>
    <dbReference type="GeneID" id="81628397"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="1">
        <location>
            <begin position="83"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="200" mass="23155" checksum="070F770621515E39" modified="2023-11-08" version="1">MAPPVSKSDKFYTVYKGRVDKPTIYSSWSQAHPRVIECEGAEHKKWDTLEDACKAMKDRGFEDVDIFVKKSAETKIVSLRKDKYYAVAGGKTTRVFTSWEDAKEAINRTTACQECFSTKQEAEEFIENWKDAYADVWRRAIRQGLNEGWKARDMSLNIGSFLLRENDNERLKEDGHEMVKTAQNELPKIEQLSVKEDNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BMB3</accession>
    <name>A0A9X0BMB3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786678.1">
        <property type="nucleotide sequence ID" value="XM_056938296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BMB3"/>
    <dbReference type="GeneID" id="81628546"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5472132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="168" mass="19690" checksum="1C54BAE00A98624D" modified="2023-11-08" version="1">MEIHNLEAKVVNLEKCKKNSEVNMLRLRKFINHATSDNKKLQIENKELKKNMPTPLVESVDVLQQQLQRREYHIDKLEEKNRHLEQKIDWMETLLLTETKNNLDLIIDGVERVDLKLISEAAICLLSNHELQVRKIDSGRAIATRPTSWFSSSLHKVSKLPMPFPLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BN45</accession>
    <name>A0A9X0BN45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786957.1">
        <property type="nucleotide sequence ID" value="XM_056937865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BN45"/>
    <dbReference type="GeneID" id="81628115"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF11">
        <property type="entry name" value="METALLOPHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040921999" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5475199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="365" mass="40289" checksum="A26FA30CAC5BED69" modified="2023-11-08" version="1">MWSCLGLTSLLIAQSTQSPIDKPVESLRFSEDGIFHISILEDLHFGENAWDSWGPEQDVNTVTVINRVLDKESPNLVVLNGDLITGENAFLENSTVYLDQMAGPLVDRGLAWASTYGNHNSSFNLSRSDLLAREKRFANSRTEAMVSDHQAGVTNYYLPVYGSGAHHRERNDMPELLLWFFDSRGGVYYQKRDASGNEIPQPNWVDVSVVEWFQATNADLVQKHGKHIPSLVFVHIPINAALAVQTQHEVDSHKEPGINDDYPLAQQGQNWCASGEYGGSCSYAGQDELLMKALAQTHGVIGVFSGHDHGDTWCYKWDKAISGIRPVNEKGINLCFGSAYGLRGVRDLDSGFSTGAGDAIEAEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BN55</accession>
    <name>A0A9X0BN55_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoglucanase-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786761.1">
        <property type="nucleotide sequence ID" value="XM_056937669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BN55"/>
    <dbReference type="GeneID" id="81627919"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="145" mass="15083" checksum="0D284CFDF89F1B3A" modified="2023-11-08" version="1">MGLVDDSTPPVTCDDDQVTANGNSWKVETPPPPKAGTWQLCPAPTDTGNIYQSLASYAIPGLAPYTGAVFTARATSVITASWNPIAESGCALTTTTAGSGPSTKKPSTTTPVTKTTTIFGNPTVDMAISLLVKSFVQCECEIKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BN83</accession>
    <name>A0A9X0BN83_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_007722</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787188.1">
        <property type="nucleotide sequence ID" value="XM_056937323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BN83"/>
    <dbReference type="GeneID" id="81627572"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
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        <source>
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    <name>A0A9X0BNJ3_9EURO</name>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">IBT 30728</strain>
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    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9X0BNY6_9EURO</name>
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        </submittedName>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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            </authorList>
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        </citation>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
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        <location>
            <begin position="96"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5477409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="339" mass="38483" checksum="4D978EFBB5DA3DF3" modified="2023-11-08" version="1">MQSPGTPYKRRPVSVTPVSSPKRPKLERATSASPFQTMTQTLARTASILYAGSTEVTRDPLQECQTALANDIQSLRWDDSRETAANQRGFEMLQFLRELKAEVETLKHNVKTLEGKNKTLEGNVKTLEGKNKTLEGHKSQSDARIQALEAQTKALGEHDTIRAAETKICRDVRLRTILSYCRPRLNKVEKTPVEQEICDMVTDQTKVHAGNVLGDASALLENFPDPADEFQHTAYRSFQKLYGTTPQRIRAADLARIPESIRTLDTIATHMYARKGRHRLTEEAFQSRQALIQLLDSREYESAEAFCLENRLFFAPREKNQESKLLEGVSEDEPDDWTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BPJ4</accession>
    <name>A0A9X0BPJ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Conidiophore development regulator abaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_007660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056937261.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81627510"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0183">Conidiation</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0749">Sporulation</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="10">
        <location>
            <begin position="122"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="8">
        <location>
            <begin position="122"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="511"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="734"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="771"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5477516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="797" mass="89471" checksum="BFB24F8D518C4FF8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BS79</accession>
    <name>A0A9X0BS79_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_006562</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788098.1">
        <property type="nucleotide sequence ID" value="XM_056936163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BS79"/>
    <dbReference type="GeneID" id="81626412"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001166">
        <property type="entry name" value="WD repeat protein (AFU_orthologue AFUA_4G09620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042238">
        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="217"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="293"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5480668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="53300" checksum="838D72137A0BAF88" modified="2023-11-08" version="1">MNSYLLNRALGSVLPKTFHTAHTTQLVHNLEPAPGIRFSNRRAAPESNNRDERDGTPFDEEDGATSESVVGHPSGVNCLAIDQFEGRYMISGGADPSIHLWDLESRGSDLHHIHRACATVSKSSHKDAHTHAITSLSIYPFDPVPSTIFSTSHDCTLKLSALEPPGITPVHTFNLDCTPYAHSFSSQPGSTLLVAVATSEHAVRLVDLRSGLATQGLPGHNAAVLSVAWAPHRPHLLASGSVDNRVIIFDVRRGGHNSAIATLDMDDPVGLAVPGSGSVPESFESRAAFSRNARAHNGPVTGVRWTSNGSHIVTTGQDSRIRVWDSGTGANTLAHFGPRVRNSSTSHLAERAPLLVPKSFTGPGQETLLWPNFNEQDDRGEIFMFELREGTYIKRLRVPGLMTGSHVARGRASALSGARINDLAWRGNGASGEGAELFSAHGDGTIRTWVSRQPDDEPDEEEEAELADRKRKRQVLDELYRGFVAPEFDLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSQ8</accession>
    <name>A0A9X0BSQ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Threonyl/alanyl tRNA synthetase SAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_006770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788306.1">
        <property type="nucleotide sequence ID" value="XM_056936371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSQ8"/>
    <dbReference type="GeneID" id="81626620"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043039">
        <property type="term" value="P:tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000008">
        <property type="entry name" value="Similar to alanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF2">
        <property type="entry name" value="THREONYL AND ALANYL TRNA SYNTHETASE SECOND ADDITIONAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Threonyl/alanyl tRNA synthetase SAD" evidence="3">
        <location>
            <begin position="250"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5480876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="296" mass="32126" checksum="92A17FAF889173B3" modified="2023-11-08" version="1">MTTSTSTSSPPASTSSPTYLAYQHDAKLLHLQTTIQSLERVSDLTEANQALFKSPGENDYILVTKETIFHPQGGGQPSDEGYIFPAQSTPSKTPDHDPSTALFQVLAARMDASNNGQVLHLVRPLASSESLLPRPNTPILLQVDSAKRLLYSRLHTAGHVLGSAVRHLLESIVPDFDELKASHFPDSASCEFRGSIGGEWKGAIQAKVTEYVGRAMPVEIEFWGEEDFAREGVSHLLPDRGLLAPGEDKFRVVRIVGAEVYPCGGTHVDSTDLCGETVVKKISRSKGNSRVSYTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BT38</accession>
    <name>A0A9X0BT38_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small ribosomal subunit protein mS35 mitochondrial conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788817.1">
        <property type="nucleotide sequence ID" value="XM_056935893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BT38"/>
    <dbReference type="GeneID" id="81626142"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="2">
        <location>
            <begin position="192"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5482845.1"/>
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    </evidence>
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</entry>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <end position="74"/>
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</entry>
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    <accession>A0A9X0BUP1</accession>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="169" mass="18944" checksum="E79948D49F3E7547" modified="2023-11-08" version="1">MSVGVSRSGRLKWKGADGGARRQQMRCKELGGRRRRRSAGLLMRECSNKIPAEETAPLAEPGTPLSSRFQMGREDERLPDVDKLSLACMVGRRKTDKAAQCTKVVLSCSLLSQSRQDPIGKRKFQKRVESHPVGYVVRMIARKFKGNNFTFVQDLAHVGKIEILRGCSR</sequence>
</entry>
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    <accession>A0A9X0BUU3</accession>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <comment type="caution">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="53986" checksum="2797DB6F865AE1B8" modified="2023-11-08" version="1">MDAQYPFATRDDLWRVFNELKGLHVRQFEQSERIARLERDREEHTRLKNVWASSLSPLHSAASGPISSVSSFNPQAEPFKGFEQGPSAAVNAVMSGVDVEYEPRRGASRANSVRFDESAIHGKNIGRSPYDRAILVLSIGWPNQHFGAVDAIYEEQQSAPRYEQSHDGLLSNVIRCWLTMNFTNETLLYAAVCSGSFVSSLGSSLIHKLSLEDQVFRDGDGRSSIKLNMWLPEASVHASSSGSSSPNPQVPSLTVHFLVHDTHSGDESIQIILGIDVLRCHNADIMFSQDKMTLVDENRSRISVPLVRPEKDWVFKLLRTAPDTTNPEYPQKSLTRRQSSVGIIGQGSPGFKYPVSAPASIRASVGEADAKRPVLALNPTDSGEVTDMPGPNATEPKTEASNVQASWRRGPRSEPSNGSKPKARPMTVLKPMKSMTRVSSGVMTPSSQAGEAPHLENSPWTARPVGDGSAKMPSKNPAGDATAFPWLNSYKPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXQ8</accession>
    <name>A0A9X0BXQ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003946</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791089.1">
        <property type="nucleotide sequence ID" value="XM_056933548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXQ8"/>
    <dbReference type="GeneID" id="81623797"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000026">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="7">
        <location>
            <begin position="45"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5489056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="473" mass="53247" checksum="AB9A333A4F547140" modified="2023-11-08" version="1">MPLRAKVTNPAFRAAASMSTSPEIPQELPGDEPDDVLFNSIYGLRSIELNRPKKLNSLNGSMARKILPRLKEWEKSHLANMILISGAGNKALCAGGDVAALALQNEKGVEGQRESTDFFGLEYRLDHTLATYRKPVISFMDGITMGGGVGLSMHAPFRIATEKTVFAMPETTIGFFPDVGGSFFLPRLDGETGTYLALTSERLNGVQALYAGIATHYLHSSVLSNMTQRLSELVFPDEMALPERLNVMNKTMAEFSLGLPSLQEEPILLAGELRSAIDRCFKFNTMEEIFQALDSETEQKEWAQKTLKTLSSRSPTSLKVTLRQMRLGKKWSITETFKREYEIAANFMRHPDFIEGVKARLMSKPPRQATWQPATLAEVSNETVDQFFNIPEGENRLEVLSKGDYQRYPHERFSLPSEAEIEKVVRESGRKASLIVEEFAEKWNFKDGVREKVSEVLARRTKNTHEGLRWIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXW6</accession>
    <name>A0A9X0BXW6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791269.1">
        <property type="nucleotide sequence ID" value="XM_056933728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXW6"/>
    <dbReference type="GeneID" id="81623977"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="109" mass="11965" checksum="39A3C3CC8FE23A71" modified="2023-11-08" version="1">MRKNPPSSRSGEHERQGGNCGTERGHKRKDVNASRLRIPKSRGTTGDALLLRSPANFDEPTKLTAKAYLAVNGRGNPRADCGSPRGDEFPLLIFYFISVLSAEDRLVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY08</accession>
    <name>A0A9X0BY08_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Nitrogen permease regulator 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Required for meiotic nuclear division protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_004261</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Vacuole membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NPR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791404.1">
        <property type="nucleotide sequence ID" value="XM_056933863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BY08"/>
    <dbReference type="GeneID" id="81624112"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056603">
        <property type="entry name" value="HTH_NPRL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24064">
        <property type="entry name" value="HTH_NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03666">
        <property type="entry name" value="NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0469">Meiosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GATOR1 complex protein NPRL3 C-terminal HTH" evidence="8">
        <location>
            <begin position="756"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="218"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="646"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
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        </location>
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            <end position="64"/>
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            <end position="130"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU368069"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF24064"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5489371.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="825" mass="90725" checksum="C6AB43F94B980538" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY43</accession>
    <name>A0A9X0BY43_9EURO</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5489134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="290" mass="31341" checksum="A909E04DA659B871" modified="2023-11-08" version="1">MSHPVKISSVNAAPGGESYISEEILARLGRADFLKLLPNGDIKIAFQVTRRMLCHYGGVLPLFNRGFSNGVFSDGSAEEIPLARVSAKALEFVGFTPETAATIWAEYSKQQSVRDSASSPHPYSPMSLLHHIVGHLHLLQGMFDAGISQELALQSVGLPPAFLNDLRTYYGDGAGFRSNVVYELVMKSITGKYTQLIRWHCTVRRIGQERISKVKKQLPVSVSCPLHSYVPLNLGGGAPANVPVPVDVPVKVPDPIPVKVPPKVSISRSTTSGVSSTVKSSSVFKPLLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYD5</accession>
    <name>A0A9X0BYD5_9EURO</name>
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    </protein>
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    </gene>
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        <name type="scientific">Penicillium diatomitis</name>
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        </citation>
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            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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        </subcellularLocation>
    </comment>
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    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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            <end position="125"/>
        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5489268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="712" mass="77456" checksum="1D7C83315976476A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYD9</accession>
    <name>A0A9X0BYD9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_003992</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791135.1">
        <property type="nucleotide sequence ID" value="XM_056933594.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81623843"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
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    <sequence length="244" mass="27688" checksum="7197CD03B34266B5" modified="2023-11-08" version="1">MTFTCERVQPTAPQLYIAVPQLISHVDWPHWSNYNRRLVKVCGVWEYCNPEMTKSEYNGQLVELPFIRIPPEISDFRKDLTSISDLEDSDIDRLTDAIHQYKQGKIANGHRSTALDTIRGIIVVSVVRPTHDENKSIEEDTERARHVLVRTQDPGNEEIVGTQSVNSSRWCTYEEEAIAAKSLRSSRWRADSRNNTQGWSSEEGVVTRTVPICSSRWCAFEKEVIGAETADLDATESETVCSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ72</accession>
    <name>A0A9X0BZ72_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002545</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792107.1">
        <property type="nucleotide sequence ID" value="XM_056932148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ72"/>
    <dbReference type="GeneID" id="81622397"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF45">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5490978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="295" mass="32681" checksum="435259910B19A013" modified="2023-11-08" version="1">MVVRAHGTQFVRLDTSDISTTPEAAIECIERDGGVIIQNLISRDLAQQIKADLKPYFDKDVPDKYGFFPETTQRASGLLGISDACVELACNPFYISVANALVSSTFAFWRDDRQVTVSGKPIISSTVGFRVNPGGRQQVLHRDDNDYHPTDKEMPVMIGCVTALTKTTKENGATIAIPGSHLWGPDRRPLNEEAIPAELEPGDAFIFLGNLYHAGGSNITRNEYRETVGIFLCKPTLRPAENQFLMVPLERARQLKPQAQRLLGYGVCDPGVGFMNYQDPMRVLFGVEDEETVNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZB9</accession>
    <name>A0A9X0BZB9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792242.1">
        <property type="nucleotide sequence ID" value="XM_056932283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZB9"/>
    <dbReference type="GeneID" id="81622532"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF174">
        <property type="entry name" value="ARRESTIN-RELATED TRAFFICKING ADAPTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="440"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5491113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="817" mass="90911" checksum="E1093E886E5A4454" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZC3</accession>
    <name>A0A9X0BZC3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_002695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792257.1">
        <property type="nucleotide sequence ID" value="XM_056932298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZC3"/>
    <dbReference type="GeneID" id="81622547"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="648"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="648"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5491128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="729" mass="81152" checksum="07A5E257895C4790" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZN7</accession>
    <name>A0A9X0BZN7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792842.1">
        <property type="nucleotide sequence ID" value="XM_056932883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZN7"/>
    <dbReference type="GeneID" id="81623132"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040914375" description="Hydrophobin" evidence="1">
        <location>
            <begin position="19"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="8822" checksum="C9D2D6EEE6972779" modified="2023-11-08" version="1">MFAKSILATVSLAGLALAGATPKAVCASNQQIVCSGNGNGGLITLGNVLPGALGDSCSGGDVYCCDSSAINQVGLVNLDVNAQCSLNHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0L9</accession>
    <name>A0A9X0C0L9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_001850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793484.1">
        <property type="nucleotide sequence ID" value="XM_056931453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0L9"/>
    <dbReference type="GeneID" id="81621702"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF152">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5493104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="351" mass="38829" checksum="566857A13DDD2329" modified="2023-11-08" version="1">MIAPSWPRIYDFIQAFRGVNSTFLTEKHVPGADLTGKWIIVTGSNNGIGLEAAKSMAAMGAHIILACREPPSWEIHPTAAVEECQQISQAHGHSASIEWWQVDLADFDSVEKFCARWLGCDRPLDVLCNNAGLAPPAQDIMTKDGFQMAHQVNLLSQVLITLRLLPSLARSAEPRIVCTTSCIHHLGLFDLDHFQGGPWKRGNDYQDNKLYYQTWVTELQSRLLRHSEYKHVTVNGVNPGFVGSSIWVPVTTATDLPTRVLKLLLRFFAITPQQGSLAITYAATSPECGPHPDTQGVGAPSGRGGGRYINRIWDAPARPICYDAEARSAVWMELDKELHLRDKGLLEILGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2H0</accession>
    <name>A0A9X0C2H0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily multidrug transporter FLU1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_000754</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794651.1">
        <property type="nucleotide sequence ID" value="XM_056930358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2H0"/>
    <dbReference type="GeneID" id="81620607"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF31">
        <property type="entry name" value="POLYAMINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="150"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5495638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="601" mass="65761" checksum="34B97E7866B171FE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2Q5</accession>
    <name>A0A9X0C2Q5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Filamentation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_000516</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YPP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794413.1">
        <property type="nucleotide sequence ID" value="XM_056930120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2Q5"/>
    <dbReference type="GeneID" id="81620369"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF464">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="623"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="740"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1062"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="804"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5495400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1159" mass="127948" checksum="51CA418128EA9EA1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C368</accession>
    <name>A0A9X0C368_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_000996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794893.1">
        <property type="nucleotide sequence ID" value="XM_056930600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C368"/>
    <dbReference type="GeneID" id="81620849"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF23">
        <property type="entry name" value="PRNX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5495880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="352" mass="38151" checksum="6DA909A850791D6F" modified="2023-11-08" version="1">MHILSEPDVTRVFRDLSQTQCHEFISILGDALQGFSAESKSNAPASKKLIHQPLRTVFSTAADNSCIFMPVSDTATIGIKVVTGTRAGIQGVINIFSPDGRLQGLLAAAEVTAFRTALASMTLFIRSQTIGKENLLIFGSGRQAEWHARLALLLYPNEIKRITFVNRGRQRLIEMERDVFADLRQRHPHVTIHTLAKEGASASDYEENLLALLASCDVIFSCTPSLEPNFAYSALQAAPRQRFISLIGSYTPEMHEIDTETLLSGGGKIYVDSRSACLEEAGELITAGITEQQLTEMGDLLSELGPSESLDVPAGANVIFKCVGMGLMDLVVGKKTLEVGKTLGLGVHVDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WK65</accession>
    <name>A0A9W9WK65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_009504</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785594.1">
        <property type="nucleotide sequence ID" value="XM_056939099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WK65"/>
    <dbReference type="GeneID" id="81629349"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="578"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1101"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="269"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="465"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1015"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1028"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5466548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1230" mass="133950" checksum="43CB6CF0ED96F01F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKL4</accession>
    <name>A0A9W9WKL4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2-oxoglutarate reductase</fullName>
            <ecNumber evidence="4">1.1.1.399</ecNumber>
            <ecNumber evidence="5">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_009488</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.399" evidence="4"/>
    <dbReference type="EC" id="1.1.1.95" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785805.1">
        <property type="nucleotide sequence ID" value="XM_056939083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKL4"/>
    <dbReference type="GeneID" id="81629333"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061759">
        <property type="term" value="F:2-oxoglutarate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12176">
        <property type="entry name" value="PGDH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000036">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000041">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008759">
        <property type="entry name" value="PRK11790.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="16">
        <location>
            <begin position="395"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5466759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="465" mass="50958" checksum="6EB1CCF0BE1DA150" modified="2023-11-08" version="1">MTSARDIRPRSDELPLHLSTSPSASFHSPSSHTSALNRTNSAVNAKHLKPFATEDIKVLLLENVNQAGRDILKKQGYQVEFLKSSLPEDQLIEKIRDVHVIGIRSKTKLSARVLKEAKNLIVIGCFCIGTNQVDLQYAAEQGIAVFNSPFSNSRSVAELVIGEIICLARQLCDRSSEMHNGTWNKVSNKCWEIRGKTLGIVGYGHIGAQLSVLAESMGMSVIYYDVLNLMSLGTARQVGSLEELLGQADFVTCHVPELPETKGMFGQQQFEQMKQGSYLINASRGTVVDIPALIEAMRSGKVAGAALDVYPNEPAGNGDYFNNDLNSWGTDLRALKNLILTPHIGGSTEEAQSAIGVEVATALTRYVNEGSTQGAVNMPEVSLRSLTIDEPSHARVVYIHKNIPGVLRRVNEILGDHNVDKQMTDSRGDVAYLMADISDVNTTQIKELYSSLESLNSRIMTRILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKP0</accession>
    <name>A0A9W9WKP0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785833.1">
        <property type="nucleotide sequence ID" value="XM_056938456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKP0"/>
    <dbReference type="GeneID" id="81628706"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5469243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="264" mass="29568" checksum="A8D1E064BE45702D" modified="2023-11-08" version="1">MLNAQRYTLHSPFTTMDTPARDAETHHSFEAPPPYYNPTTTDNTTTTSSSSSIYPLDEKDLLLTPGSHEPGLATSAVLTRGLQIPTRTGTTTSGFPYPAELAHFGISQHHWQQFTELICEEAKLSRQQWSTVIGKGLGTLALGGLMIGALSAIPAIWMTRHVRRRQEQRNFIAAMAGARGERLATHISEWNETFFRPRGVMIRVDLPDEYINEMDQMDVYRKDGKYMRSVEEARDKAALKARIVIIPVDVHVDVPESSQSSIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL12</accession>
    <name>A0A9W9WL12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_009400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785717.1">
        <property type="nucleotide sequence ID" value="XM_056938995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL12"/>
    <dbReference type="GeneID" id="81629245"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF23">
        <property type="entry name" value="MOSC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G05900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="274"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5466671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="452" mass="50283" checksum="E2DC9CFD7959D211" modified="2023-11-08" version="1">MWAWIEDQLNGQLLVKVSPLSVGFALLSSAVLAIVPLLTLAKSISRSRALRQSPPGCRRLGLPFNQSNLSDEFDRKYAQGTSPDSKDEDGLPSWRVKALFTYPIKSCRGIELEHADVVSTGLQYDRQFAFAQHTPKGWVCRTLRNAGFERMALIHAEIWIPDPSSPSYETRRPEIRSGGVMIVSYPRVTPSGLLGTIIRTGVMLGLVASRESFTVPLQPETPAEIEIDSPSQPSYPLKPVTIWKDSPLAHDYAIHLPPSLHKYLGFHHPSSSPLTLFRAHSTHPRNIYRNAPRKAQLGFQPQTAFADAYPIHLTLSSHHDVAARCASSLPHLSIRRFRANIIIEGPGPFAEDQWKKVRIGNTDVYAACRTIRCLLPNVDPDTGVRHASQPDRTLKGYRRVDEGDLTNACLGLQLVPGVREWVVRVGDEVRVLETGVHRYIKMLAPGEKVEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQF2</accession>
    <name>A0A9W9WQF2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786342.1">
        <property type="nucleotide sequence ID" value="XM_056938334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQF2"/>
    <dbReference type="GeneID" id="81628584"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5471796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="100" mass="10548" checksum="65005EBA4A1D9418" modified="2023-11-08" version="1">MTTSPSALCALFTNPSTAAMAGESDATSKTTKDQKVRVDDIARDDGLLKAKVKELTGEDVTVSPTNFEVHDLDSVDWNTACALLVQIDGGIVELDGGSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQN7</accession>
    <name>A0A9W9WQN7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_008481</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786458.1">
        <property type="nucleotide sequence ID" value="XM_056938076.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81628326"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022099">
        <property type="entry name" value="DUF3638"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022105">
        <property type="entry name" value="DUF3645"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046541">
        <property type="entry name" value="DUF6606"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF33">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
        <property type="entry name" value="DUF3638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12359">
        <property type="entry name" value="DUF3645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20255">
        <property type="entry name" value="DUF6606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUF6606" evidence="9">
        <location>
            <begin position="4"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3638" evidence="7">
        <location>
            <begin position="1756"/>
            <end position="1977"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3645" evidence="8">
        <location>
            <begin position="2095"/>
            <end position="2127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5471912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="2829" mass="320973" checksum="3FCDC9DAD0DA0CED" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQS3</accession>
    <name>A0A9W9WQS3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786522.1">
        <property type="nucleotide sequence ID" value="XM_056938140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQS3"/>
    <dbReference type="GeneID" id="81628390"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="614" mass="69286" checksum="F247BD1F5298984A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQZ2</accession>
    <name>A0A9W9WQZ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tryptophan synthase</fullName>
            <ecNumber evidence="3">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_008587</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786564.1">
        <property type="nucleotide sequence ID" value="XM_056938182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQZ2"/>
    <dbReference type="GeneID" id="81628432"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF2">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="10">
        <location>
            <begin position="13"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5472018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="228" mass="24341" checksum="9F84C59FCD4EEEA9" modified="2023-11-08" version="1">MGADDDKKQNNGIREIEKLGALLLRVRCLSGAATLRTAIAEAFRYVALYYDTAYYLMGGVSGPQPIPGMTATFQQRLGAEVANQFQVESENQPDALVAAIGTGTGAIGLFRQFIDSAGAQVGVLHGTKTLVLRHDEGQILDSSCVSPDLNISVVGPEVANWKISGLVEIYPVTDEEARRGLDILSKYKKVKAGLDCSHAVIKAMEIAKELGPVKHVILLATGDDAIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WR17</accession>
    <name>A0A9W9WR17_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786600.1">
        <property type="nucleotide sequence ID" value="XM_056938218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WR17"/>
    <dbReference type="GeneID" id="81628468"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5472054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="37898" checksum="B69FB97A2EC42169" modified="2023-11-08" version="1">MNSLSHIIDPEGEVIITLRNANSPFAKPTRDTWIHQWLESSQTSSSKSIPLSRLSLLKSPTIEATVAEESVAEGHLGQNCSRIQVSAKHLMFASPFFKRLLTGGWKESVAYFQKGSVEITAESWDVEALMIMLAKIAAIADYYECREALDFLAELWIEKMEEETPSVASRDLILWLWVSWVIQLPTQFKLSTSIASSQSDGFIDNLGLSIPEDVIVSINRRREEAIERLIDLIDYTRRQYLLGARGCRLECRSIMYGALTIQSKDLLLPHREFPFPNVSYRSLVQKMTNFRSLEWYDSPSKCINKHSCPGSSFASTFGALDGFLEGLELEQFNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WR59</accession>
    <name>A0A9W9WR59_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786660.1">
        <property type="nucleotide sequence ID" value="XM_056938278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WR59"/>
    <dbReference type="GeneID" id="81628528"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5472114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="42832" checksum="BF69839F7767280E" modified="2023-11-08" version="1">MAFHSPVRGQEWRNSVRPDIPIWKTSFDHTRSHIPEDEFRQLPLNSDSTAPEFPTPDSGSTYEPSSSPPDAPESTARQVSTRSRVSCAPSDVRHCSRSSQSPDPDSKPATRRKRAFSQVPSSPSAQRVARQRDTNNDKGPDSQSRHRDAQFCTQRCLLGLQSGGVLDNCCPNVMLHRQSKDDLQHPITSEDLVRLLKAQLDENIDRCKPLGNCGAYGAPFKLTCVVYGYTVIGKGTTSELWKEVSREAEVYRVLQKAQGSAVPVFLGTIDLAKIYFLHGAGKIRHMLVMGWGGENTASMVLTPWLHREIRKSNKEIKALGIIHEDLRRDNVLWNKELGRALIIDFHRYTLKCRPTLQRSRAVKRQLCLPETRDPKRLCVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTA4</accession>
    <name>A0A9W9WTA4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin cytoskeleton-regulatory complex protein SLA1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">High osmolarity signaling protein SHO1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Osmosensor SHO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">N7539_008149</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SLA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786841.1">
        <property type="nucleotide sequence ID" value="XM_056937749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTA4"/>
    <dbReference type="GeneID" id="81627999"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11773">
        <property type="entry name" value="SH3_Sla1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11775">
        <property type="entry name" value="SH3_Sla1p_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000256">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.700">
        <property type="entry name" value="SLA1 homology domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056996">
        <property type="entry name" value="PH_SLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
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</entry>
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</entry>
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        </citation>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5475335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="142" mass="16181" checksum="5727268565E74BDD" modified="2023-11-08" version="1">MSTVNMVKYYFYKGMIPKDRDRLRQLVALAYQTARDRKLYPKAVLIRSEVHDTTSINGMHQKDPLGPHVTLCYKDKNQLLQGTHVASHGYVRGKDDIGFVRATHTGEKSDSARRQQGKKTVWPSENELEAAPEIGYSHLPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTU1</accession>
    <name>A0A9W9WTU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_008063</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5474997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786755.1">
        <property type="nucleotide sequence ID" value="XM_056937663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTU1"/>
    <dbReference type="GeneID" id="81627913"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="188"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="236"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5474997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="799" mass="87758" checksum="58324B7403A418DF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUB7</accession>
    <name>A0A9W9WUB7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Low molecular weight phosphotyrosine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_007758</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787224.1">
        <property type="nucleotide sequence ID" value="XM_056937359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUB7"/>
    <dbReference type="GeneID" id="81627608"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002115">
        <property type="entry name" value="Tyr_Pase_low_mol_wt_mml"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF7">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00720">
        <property type="entry name" value="MAMMALPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="7">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR617867-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5475471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="161" mass="17781" checksum="EB0F3669AF1025F0" modified="2023-11-08" version="1">MAEGVFRNVAQSHDVIGQIDSAGTAAYHAGESPDSRTMATLRRHGITNYKHAARKVTKDDFLKFDYLLGMDQSNLQDLLDMRDSVVAGLRRKASTPGDDVRVAEVRLFGDFGRGGKLHARVGGGEVVEDPYYGGANGFEEVYKQVVRFSESFVDHLESQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUF9</accession>
    <name>A0A9W9WUF9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">Ketol-acid reductoisomerase, mitochondrial</fullName>
            <ecNumber evidence="5 17">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">Acetohydroxy-acid reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 17">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">N7539_007986</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 18">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="5 17"/>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787452.1">
        <property type="nucleotide sequence ID" value="XM_056937587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUF9"/>
    <dbReference type="GeneID" id="81627836"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000003">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000005">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000013">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000167">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016207">
        <property type="entry name" value="KetolA_reductoisomerase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371:SF1">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000119">
        <property type="entry name" value="Ilv5_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 17 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 17" id="KW-0521">NADP</keyword>
    <keyword evidence="11 17 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="19">
        <location>
            <begin position="56"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="20">
        <location>
            <begin position="247"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00072637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ5475699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="396" mass="44039" checksum="C8E8E4D394906E9B" modified="2023-11-08" version="1">MAARGLPRALRLARVAAPRSVVTAALPRPALASVARRAIAPITPVRGVKTIDFAGVKEDVYERADWPREKLHEYFKNDTLALIGYGSQGHGQGLNLRDQGLNVIVGVRKDGASWKEAIEDGWVPGKNLFDVNTAIEKGTIVMNLLSDAAQSETWPTIKPLITKGKTLYFSHGFSPVFKDLTKVEVPKDVDVILVAPKGSGRTVRSLFKEGRGINSSIAVYQDVTGQAKEKAIAMGVAVGSGYLYETTFEKEVYSDLYGERGCLMGGIHGMFLAQYEVLRERGHSPSEAFNETVEEATQSLYPLIGGYGMDWMYAACSTTARRGAIDWSSRFKDNLKPLFNELYDSVRDGTETQRSLDYNSQKDYRQKYEQEMEEIRNLEIWRAGKAVRGLRPENQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUJ0</accession>
    <name>A0A9W9WUJ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Glutamate synthase [NADH]</fullName>
            <ecNumber evidence="19">1.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">N7539_007132</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="24">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="24">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.14" evidence="19"/>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5476988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787532.1">
        <property type="nucleotide sequence ID" value="XM_056936733.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81626982"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00713">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000160">
        <property type="entry name" value="Glutamate synthase (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000006">
        <property type="entry name" value="Glutamate synthase (NADPH/NADH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000031">
        <property type="entry name" value="Glutamate synthase 1 [NADH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000017">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000113">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000022">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.60:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="entry name" value="Glutamate synthase, alpha subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012220">
        <property type="entry name" value="Glu_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008730">
        <property type="entry name" value="PRK11750.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000187">
        <property type="entry name" value="GOGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18 24" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0288">FMN</keyword>
    <keyword evidence="17" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="16 24" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="26">
        <location>
            <begin position="53"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="944"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="955"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="23">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1167"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1173"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1178"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00057049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00068518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAJ5476988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="2101" mass="231257" checksum="99F57218A8ECEA84" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVP3</accession>
    <name>A0A9W9WVP3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_007529</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787929.1">
        <property type="nucleotide sequence ID" value="XM_056937130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVP3"/>
    <dbReference type="GeneID" id="81627379"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14502">
        <property type="entry name" value="RNA_5'-triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000273">
        <property type="entry name" value="Dual specificity phosphatase catalytic domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000090">
        <property type="entry name" value="Dual specificity phosphatase catalytic domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF25">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE CATALYTIC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="650"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5477385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="745" mass="82850" checksum="91B7C4E758B2F885" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1Q9</accession>
    <name>A0A9W9X1Q9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Patatin-like phospholipase domain-containing protein</fullName>
            <ecNumber evidence="9">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_006657</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Lipid hydrolase.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788193.1">
        <property type="nucleotide sequence ID" value="XM_056936258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1Q9"/>
    <dbReference type="GeneID" id="81626507"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07230">
        <property type="entry name" value="Pat_TGL4-5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF10">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PNPLA" evidence="11">
        <location>
            <begin position="228"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="593"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="752"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="8">
        <location>
            <begin position="259"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5480763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="778" mass="87028" checksum="ADCD0F46CFF0E57A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1Z0</accession>
    <name>A0A9W9X1Z0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788399.1">
        <property type="nucleotide sequence ID" value="XM_056936464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1Z0"/>
    <dbReference type="GeneID" id="81626713"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5480969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="65379" checksum="6AE00C755D28B378" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2N3</accession>
    <name>A0A9W9X2N3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_006931</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788467.1">
        <property type="nucleotide sequence ID" value="XM_056936532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2N3"/>
    <dbReference type="GeneID" id="81626781"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5481037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="510" mass="56188" checksum="C0393A583CDE6C39" modified="2023-11-08" version="1">MAGIMDTVSNLINKITGPAEEVPREPSADEFKHLQKKYTDAGQGQVFAFVDELETVDKSRLYHQLSTFDVTRINELADRALNPPKTEETAATLEPLPASATASIIDSDPTDLKNWYNAGLKEVADNKVAVVLMAGGQGTRLGSSAPKGCFDIGLLSEKSLFQLQAERIVKLQELANQAHGTQSAVIPWYVMTSGPTRKPTEEFFEKNKFFGLSKENVFIFEQGVLPCISNDGKIIMESKSKVAVAPDGNGGIYQAIVTSGVREDMRKRGIQHIHAYCVDNCLVKVADPVFIGFSASKKVDIATKVVRKRDAAESVGLILQKNGKPDVVEYSEIDQATAEAKDPKDPELLKFRAANIVNHYYSFSFFESIENWMHKLPHHVARKKIPHVDPESGEAVKPTSPNGVKLEQFVFDVFPMTPLEKFACIEVRREDEFSPLKNAAGTGQDDPDTSRADIMKQGQRWIEAAGGIVVTEGDKFGVEVSPLISYGGENLEFLQGREIKAPAIIEKEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2N7</accession>
    <name>A0A9W9X2N7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mpv17/PMP22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_007029</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788565.1">
        <property type="nucleotide sequence ID" value="XM_056936630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2N7"/>
    <dbReference type="GeneID" id="81626879"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5481135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="173" mass="18966" checksum="910C48E50295D666" modified="2023-11-08" version="1">MLRWYQSKLAKRPILTASITSAVLFGSGDVLAQQLVDKRGLEKHNFARTGRMALYGGAVFGPVATKWFGILQRHVVLGGTATTTIARVAADQVVFAPVQLSFFLSSMAIMEGVDPVEKWKKAFGPAYKANLMVWPFVQGINFAFVPLELRVLVVNVVSLGWNCFLSLMNSGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2T0</accession>
    <name>A0A9W9X2T0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788795.1">
        <property type="nucleotide sequence ID" value="XM_056935871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2T0"/>
    <dbReference type="GeneID" id="81626120"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5482823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="63" mass="6837" checksum="6A4C59AEF4FEC443" modified="2023-11-08" version="1">MQPTMAHVPMAGVVDNEQMMVFVAVHSPVVKCLVNLSAQDLSWEISISDAVTTSCFTKGLKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2V3</accession>
    <name>A0A9W9X2V3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788587.1">
        <property type="nucleotide sequence ID" value="XM_056936652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2V3"/>
    <dbReference type="GeneID" id="81626901"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF7">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5481157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="40291" checksum="63F86F4112AB2CB6" modified="2023-11-08" version="1">MSTTTTSTTTKTTLANPNLHGHGRMRLDGTDKQFGDWRDDLARDGYAVVKGAIPRERAMKYADQMYSWLESFNLGYDRNDPSTVHKDKLPVINEKGMCLAYGLSHEDFVWGVRSEPGVVGAFEKVYDDEDLIVSFDAINFQFPNRTDLPPNKPWPHQDQDPTKHGFRCMQGLVNLLPNGPDDGGLIVCKGAHLLSEQFHHDNADEERIPAWTPEWFGFTDRGMKWLADHGCEWTKLTAEPGDLLVWDSRTPHYNLSPKRDQPRFAIYTCFMPVADATQEDLRRKKDAFDRRVGTTHWPNARHTGSNVAQRDGKPDPHNRDRPVNDPKLSERAFKLTGIPYIKDDSATIAQTTVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X4Y9</accession>
    <name>A0A9W9X4Y9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_005725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789199.1">
        <property type="nucleotide sequence ID" value="XM_056935327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X4Y9"/>
    <dbReference type="GeneID" id="81625576"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5483929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="102" mass="11609" checksum="B6379652B6EF1CC9" modified="2023-11-08" version="1">MPRPRYRPADCSPIFKPPPVILFSHDGRSDASAEEACKVYMANRPDHHVALVRRTPAQLGYEVWHSGGQDHHAPEHMTVQFSDKNGVWLETVHLDRQGRLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5H7</accession>
    <name>A0A9W9X5H7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">COBW domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_005874</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789348.1">
        <property type="nucleotide sequence ID" value="XM_056935476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5H7"/>
    <dbReference type="GeneID" id="81625725"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF31">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="8">
        <location>
            <begin position="37"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="CobW C-terminal" evidence="9">
        <location>
            <begin position="327"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5484078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="397" mass="43499" checksum="8FFB351B0700C508" modified="2023-11-08" version="1">MASTIDDEDMPPELVDVTIMSAAPDSVKEEESTPRVPITIVTGYLGAGKTTLLNYILTEKHGKKIAVIMNEFGDSSDIEKPLTVNEGGQEVTEWMEVGNGCICCSVKDTGVMALESLMERKGTFDYILLETTGLADPGNIAPVFWMDDGLGSSIYLDGIVTLVDAKNILRLLDEPAPEEKADAHNEEAHEHGSGPILSMAHMQISHADVIIVNKADLVTPEQMDAVRDRVSAINSVAKIHVTDHSRTPQIEGVVLDLHAYDHLDDLDFSKKGHSHIDPAISTIAVTIPPVSADQIPRVDSWLQSVLWESTLPQPRSGSRDGHPVQFEIHRLKGILRLQDGSCKIIQAVRDVFEIRDSEARKDDDKPSQDQCKIVLIGRGLGPVLDPWKQSLEAFIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5R5</accession>
    <name>A0A9W9X5R5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">biotin synthase</fullName>
            <ecNumber evidence="3">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_004857</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789653.1">
        <property type="nucleotide sequence ID" value="XM_056934459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5R5"/>
    <dbReference type="GeneID" id="81624708"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="BIOTIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976:SF2">
        <property type="entry name" value="BIOTIN SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01278">
        <property type="entry name" value="biotin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Radical SAM core" evidence="17">
        <location>
            <begin position="81"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5484869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="359" mass="39550" checksum="24492DD70FFEEEAB" modified="2023-11-08" version="1">MSWTWSRSLSRTAWRSYGTVQGSPSAAAIASRVPSALVEATSATAPRTNWTPEEINAIYHTPLNQLTYAAAAVHRRFHDPSAIQMCTLMNIKTGGCSEDCSYCAQSSRYDTGLKATKMSPVDEVLEKARIAKANGSTRFCMGAAWRDMRGRKTSLKNVKQMVSGIRDMNMEVCVTLGMIDGEQAKELKEAGLTAYNHNLDTSREFYPTIITTRSYDERLRTLDHVRDAGINVCSGGILGLGESDADRVRHPLGDRKMIPFDRVLRTIATARVVMPATIVRLAAGRIAMSEEQQVACFQAGANAVFTGEKMLTTDCNGWDEDRAMFEKWGYYPMKSFEKPELRDSSSLSSASPLSPSPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5V1</accession>
    <name>A0A9W9X5V1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_004855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789651.1">
        <property type="nucleotide sequence ID" value="XM_056934457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5V1"/>
    <dbReference type="GeneID" id="81624706"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5484867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="436" mass="48803" checksum="C98C0573785C2DFC" modified="2023-11-08" version="1">MPRRPKGLKSRYGCSECKRRRVKCDETKPSCLNCNRLGQSCSYTLITPQFCGGTKPVPSSIKWQPPKSGQPDRCVFRLRDMQLLHFFTMKTAETLSSHPEVQNAWKTTVVDAAFANSFLLQGLLALAALHLASQSSADGEDLSILAATKIEQALVQFRHEVRCLSSQNCDAVFIFSVLIAFYIPASAGTAINPSANFFGDDFSVSVVKWMRLFRSARDVYDQYTSQIRERSLSILISWYDRDLPPPTSSIPLPEGIPINEYLADQLKRVGVPEAELAYLISTSHPEAAQTNVRALNLALELFGIDGEHPKLLEAQWKVYMPTTLGRSGHPWHSTDGVDWLSRSFAWLFWIPLQFIELLESRDNISLIIFACFGLGFGRAPGKWWNSHIPGLVMEMVHRNLPPDSRELFSYILPARSDDGLADCAITASVHPHVSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6C4</accession>
    <name>A0A9W9X6C4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_005168</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789964.1">
        <property type="nucleotide sequence ID" value="XM_056934770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6C4"/>
    <dbReference type="GeneID" id="81625019"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16514">
        <property type="entry name" value="RING-HC_LONFs_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF42">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="237"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Lon N-terminal" evidence="8">
        <location>
            <begin position="322"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="670"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5485180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="691" mass="77352" checksum="0334B6ADEEDCBD5D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6G8</accession>
    <name>A0A9W9X6G8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWR1-complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_005017</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789813.1">
        <property type="nucleotide sequence ID" value="XM_056934619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6G8"/>
    <dbReference type="GeneID" id="81624868"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="150"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="93"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="340"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="487"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="487"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5485029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="590" mass="66690" checksum="82681CC2419391F8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X738</accession>
    <name>A0A9W9X738_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle receptor subunit alpha homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Docking protein alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_004873</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789669.1">
        <property type="nucleotide sequence ID" value="XM_056934475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X738"/>
    <dbReference type="GeneID" id="81624724"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17876">
        <property type="entry name" value="SRalpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000566">
        <property type="entry name" value="Signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000009">
        <property type="entry name" value="Signal sequence receptor alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000023">
        <property type="entry name" value="Signal sequence receptor alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="12">
        <location>
            <begin position="624"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="133"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5484885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="651" mass="70167" checksum="D7ABD5EA40FE6C7F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XBS0</accession>
    <name>A0A9W9XBS0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Apoptosis-inducing TAF9-like domain 1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_003374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TAF9 family. CENP-S/MHF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790517.1">
        <property type="nucleotide sequence ID" value="XM_056932976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XBS0"/>
    <dbReference type="GeneID" id="81623225"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22919">
        <property type="entry name" value="HFD_CENP-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000098">
        <property type="entry name" value="Apoptosis-inducing TAF9-like domain 1 family protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029003">
        <property type="entry name" value="CENP-S/Mhf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980:SF0">
        <property type="entry name" value="CENTROMERE PROTEIN S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980">
        <property type="entry name" value="CORTISTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15630">
        <property type="entry name" value="CENP-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5488484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11337" checksum="C069F974A6DA4E63" modified="2023-11-08" version="1">MEQVEDAGLEERLKSALWLSIGKIVDEETMKLGVNATPQFIGALTEMVWSQIETVGQDLESFAKHAGRSTVNVSDVMLLARRNEGLESILRTFVEQAREAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCR4</accession>
    <name>A0A9W9XCR4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial oxaloacetate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_003899</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791042.1">
        <property type="nucleotide sequence ID" value="XM_056933501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCR4"/>
    <dbReference type="GeneID" id="81623750"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051508">
        <property type="entry name" value="Mito_Carrier_Antiporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928:SF1">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="107"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="208"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5489009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="331" mass="36009" checksum="966AB42DBDF99F8E" modified="2023-11-08" version="1">MSTTTGAFLAGGIAACGAVTVTHSFETVKIRLQLQGELQSKNEGVKKYRGVLHGVKVILQNEGPRGLFRGIGSAYIYQVLLNGCRLGFYEPIRSTVTNAIYSDPKVQSLGANVFAGAASGVIGAAAGSPFFLVKTRLQSFSPFLPVGTQHNYKNSIDGLSRIYQSEGVKGIYRGVGAAMIRTSFGSAVQLPTYFFAKRRLTRHLGMEEGPALHLASSAASGFVVCCFMHPPGMPRLSIPDVASDDYTDSMTTDTIMARMYNQTGNLYQGVFDCLFKTIRTEGVLAIYKGFFAHLARILPHTILTLSLAEQTNKLMRRFESRILPDALKEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCV8</accession>
    <name>A0A9W9XCV8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_003847</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EIF1AD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790990.1">
        <property type="nucleotide sequence ID" value="XM_056933449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCV8"/>
    <dbReference type="GeneID" id="81623698"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039294">
        <property type="entry name" value="EIF1AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN EIF1AD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="26"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5488957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="138" mass="15654" checksum="CC50A2420FA27843" modified="2023-11-08" version="1">MAPPRRKVLATAEGTMFPPDELSSTQQIVRAVKATGNNIYLIEQADKTQMLVELPAKFRSTFWIKRGSYVVIDTEPQEERDNKIKGEIINIVRDEKAWRKAPFWPKEFAKQPAVVVDSDSDEEESRVGKMPSSDESDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDB2</accession>
    <name>A0A9W9XDB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791154.1">
        <property type="nucleotide sequence ID" value="XM_056933613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDB2"/>
    <dbReference type="GeneID" id="81623862"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027911">
        <property type="entry name" value="DUF4604"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15377">
        <property type="entry name" value="DUF4604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4604" evidence="2">
        <location>
            <begin position="6"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="169" mass="18774" checksum="BC7DE26B9F6B1B40" modified="2023-11-08" version="1">MPKNAKLAYEAKEPAFLQKLRGHYGDNSGRLERPAARPRKLKDKNEDDDDAPVYVDETSNEVISKTEYEALVRGVSNEKPDDSCGTSEAGEQDERDVQSQAENQLSRQQKNLLEIGGPKKRKQAKLVGDDEQSESAAQQAKLQALPSKPQGHKKAKNIKKIKLSFADAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDB5</accession>
    <name>A0A9W9XDB5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7582 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791230.1">
        <property type="nucleotide sequence ID" value="XM_056933689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDB5"/>
    <dbReference type="GeneID" id="81623938"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056004">
        <property type="entry name" value="DUF7582"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24483">
        <property type="entry name" value="DUF7582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7582" evidence="2">
        <location>
            <begin position="66"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="216" mass="25037" checksum="F778325E8D29B576" modified="2023-11-08" version="1">MERGKDRFGAEDFKQGLAVLDHEMGKDDWLVAFAPITLISTGGFLATNFFRNRESTGDIDYLLDPQWAHDNEIKRPLQNAITRAARRLGFIDDWVNEELAFFVPDQFRQLLFEKAEEQDIVLWEGKHLRVLAVPLEWALERKLRRIHHSKRHAKRGSDIADVLAILRHMRAQQGGPLDGEYIRTLNICSFELAPDLITMAEIATAYRKQYDEEIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE01</accession>
    <name>A0A9W9XE01_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791592.1">
        <property type="nucleotide sequence ID" value="XM_056934051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XE01"/>
    <dbReference type="GeneID" id="81624300"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052292">
        <property type="entry name" value="Glucose_repression_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051:SF1">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="576" mass="63402" checksum="A01E12091C520E3A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE71</accession>
    <name>A0A9W9XE71_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_004491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791634.1">
        <property type="nucleotide sequence ID" value="XM_056934093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XE71"/>
    <dbReference type="GeneID" id="81624342"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF8">
        <property type="entry name" value="ACID PHOSPHATASE PHOA (AFU_ORTHOLOGUE AFUA_1G03570)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040846348" description="Acid phosphatase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5489601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="39134" checksum="B8F8D9D563FB18C8" modified="2023-11-08" version="1">MKFAVGALLASLSLAAAVPVEVATSVEAKNHVKPVKGRWFERFVVIVLENTNRGVTMGDPYFLNLTHWGMLLNGYHGSTHPSQPNYITMITNTIAAGVYDDSDHNSTAYNLVDLLEPAGITWKAYMEGYKPKANGDCNPYHEDKETLYVRKHNPFMSFDNIRNNTARCQNIVNAEEHFAKDVAKGHDAPMYMYYVPNLNNDAHDTNISYAAKNTQKVIDTMLNDKAFMKDTVILLTFDEDNVYTNDNYGDPNSIYSLLLGNDTVKCYDCVDQTYYNHFSQLVTVERNWNLSTLPGEGWDQWWRPFGQLRTSKDENCAFAPCSEYYDGKSPARSNSNWNDDGLEGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE86</accession>
    <name>A0A9W9XE86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_004569</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791712.1">
        <property type="nucleotide sequence ID" value="XM_056934171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XE86"/>
    <dbReference type="GeneID" id="81624420"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000065">
        <property type="entry name" value="Similar to histidine acid phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF14">
        <property type="entry name" value="ACID PHOSPHATASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040794091" evidence="4">
        <location>
            <begin position="18"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="49"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="396"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5489679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="441" mass="49231" checksum="B471C6DDC1C5AB56" modified="2023-11-08" version="1">MQFTTLMLALTATPALASFNFNPLEHSAGISPYFSPHNPPIAVSPPQGCNVTRAAFLIRHAAIYANDFDYESYLEPLVKKLRNTTQDWASTQSLRFLANWTAPVDDEHLERLTRFGMQQAMLLGADIRQRYNHLDLPKRVWSSTADRTVKSAEAFLAGYTHNNTKLVNLTQIEESKKLGADSLTPYKSCKAYSSSYGSKQSSKFIDVYTKPIIARLKAEVPRFNFTQDDITAMFEFCGYETVIRGDSPFCAPTLFNADEWLGFEYANDIMYFHNAGYGRELSPSLGFPWVNATVSALDDESSSQELYVSFTHRELPPTVITALGLYNNSAFTGANDVNQTMPNNTINYNRAWKSSEILPFLTNIAIEKMSCESPGFDEGSYYRVLNNASPQPLVGCRDGPGGSCSQDQFLKFMKTRGESYGDFNKACDGDNLPSSLSIYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEK5</accession>
    <name>A0A9W9XEK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-L-fucosidase</fullName>
            <ecNumber evidence="3">3.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002311</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791873.1">
        <property type="nucleotide sequence ID" value="XM_056931914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEK5"/>
    <dbReference type="GeneID" id="81622163"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF37">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="7">
        <location>
            <begin position="318"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5490744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="768" mass="85625" checksum="4EFBAA0EA01140FA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XER2</accession>
    <name>A0A9W9XER2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792049.1">
        <property type="nucleotide sequence ID" value="XM_056932090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XER2"/>
    <dbReference type="GeneID" id="81622339"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5490920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="229" mass="25751" checksum="1F9CABE6B1A0E711" modified="2023-11-08" version="1">MPVYMLHGFRWPRAGFTGIRVYIVLNNLEEAAAEYIQQPLTTELLLESFRKTQADLMPRLPELQFIEQYDPHDESSNTVSQEYAYVGAKVVTVPDGADANGDLEKVVEQGSGLSEDATQALEALRDRLAPQEKIGWFMVYNGDPDRWYPSSDEEEHDEDDEYEGEEEQEESGVSEKSVAQTDSQTAPPTPQSYTVCHWDNDHRQSLGGQSGFPELIQGFLHSGTFDAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEV3</accession>
    <name>A0A9W9XEV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucan endo-1-3-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_002537</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792099.1">
        <property type="nucleotide sequence ID" value="XM_056932140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEV3"/>
    <dbReference type="GeneID" id="81622389"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000023">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000026">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051801">
        <property type="entry name" value="GH28_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31339">
        <property type="entry name" value="PECTIN LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31339:SF9">
        <property type="entry name" value="PLASMIN AND FIBRONECTIN-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040725748" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="3">
        <location>
            <begin position="63"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="3">
        <location>
            <begin position="635"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="514"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5490970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1002" mass="104915" checksum="E9CBD215A67C5343" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF20</accession>
    <name>A0A9W9XF20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_002549</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792111.1">
        <property type="nucleotide sequence ID" value="XM_056932152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF20"/>
    <dbReference type="GeneID" id="81622401"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF6">
        <property type="entry name" value="AMIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="96"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="235"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5490982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="571" mass="61549" checksum="863CB851B733BF40" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF78</accession>
    <name>A0A9W9XF78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">N7539_002736</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="17">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792298.1">
        <property type="nucleotide sequence ID" value="XM_056932339.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81622588"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 18" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="562"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1003"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1036"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1087"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1110"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1148"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1179"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1321"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="285"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="20">
        <location>
            <begin position="388"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="21">
        <location>
            <begin position="1030"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="230"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1263"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1340"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="128"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1371"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1384"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1421"/>
            <end position="1436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAJ5491169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1436" mass="155644" checksum="4F3482056973D991" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFL2</accession>
    <name>A0A9W9XFL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GTPase Obg</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_002937</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056932540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFL2"/>
    <dbReference type="GeneID" id="81622789"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.210.12:FF:000001">
        <property type="entry name" value="GTPase Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="6">
        <location>
            <begin position="76"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="302"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5491370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="566" mass="62100" checksum="05DCD7F9BD69FACF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGZ9</accession>
    <name>A0A9W9XGZ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tryptophan--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_003170</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792731.1">
        <property type="nucleotide sequence ID" value="XM_056932772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGZ9"/>
    <dbReference type="GeneID" id="81623021"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000082">
        <property type="entry name" value="MSW1p Mitochondrial tryptophanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5491603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="411" mass="45672" checksum="7D36EB761EB1315C" modified="2023-11-08" version="1">MLAPSFHKGSIPMKSIHGQLCRTRPTMPHARPIRRPYMNIYQTTRLSSNKSPQANSNTAKCTPSGPSPRVVFSGIQPTGVPHLGNYLGALREWVKLQDEAEPGTKLIFSIVDLHALTVSQEAAQLRRWRKEAFATLLAVGLDPKRSTIFYQSEVPAHAELMWILSTVASMGYLSRMTQWKSKLQLPEDTTLEQADARAQLRLGLFSYPVLQAADILVHRATHVPVGEDQRQHLEFSRYTANSFNHLYGPIFPIPEAQISPAKRVMSLKEPTSKMSKSHPDPKSRILLTDSPSTIHKKIKVALTDSQPLITYDPAHRPGVSNLLEILSHFESRSCEQIAGEFEGASLRVLKEHVAARISAHLEAVRDRYEEVMGDRTGYLKSVAREGAERAGGKCEGDDEDGEGCDGVIEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHA6</accession>
    <name>A0A9W9XHA6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="2">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_001614</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793248.1">
        <property type="nucleotide sequence ID" value="XM_056931217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHA6"/>
    <dbReference type="GeneID" id="81621466"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="9">
        <location>
            <begin position="56"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="8">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5492868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="277" mass="30717" checksum="BB34C3F33DE52A34" modified="2023-11-08" version="1">MASTQTLQSKYKLRSGHEIPILGFGPSFFDRKGGLGSVEEWISSCTSHLLAQCFACGRAIRSSGIDRSEIFFTTKIPPESMGYGDTKRAVESSLREAGLDYFDLILIHAPYGGKEARLGSWRALVEAQQAGKVRSIGVSNYGIHHLEELEDYIQNGGGGEISVGQYELHPWLDHSDIAEWCQSRGIVVEAYSPLAHGTRFREPVLSQIGEKYGKSPAQVLIRWSLQMGFVPLPKSAKTQRIPQNANVFDFELSQEDMGLLDTGEYSPTDWDPTVDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHR9</accession>
    <name>A0A9W9XHR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793504.1">
        <property type="nucleotide sequence ID" value="XM_056931473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHR9"/>
    <dbReference type="GeneID" id="81621722"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609">
        <property type="entry name" value="RFEG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="143" mass="15908" checksum="D5C4C167737B65ED" modified="2023-11-08" version="1">MSPGHQQYWLPGYGLSRHIVLGQIHCFLGPSASARPYSYQVPMALLSLLDSGREGYLITGMPLTRQVQDQIDDLAAMSREYEKQEALRMTTHSSSASIQISPGAGGDGSSRRSSEPYINEIIPVDFQRTRRRPVEQTSSRTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI93</accession>
    <name>A0A9W9XI93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11 12">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 11 12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_002234</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11 12">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 11 12"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793868.1">
        <property type="nucleotide sequence ID" value="XM_056931837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XI93"/>
    <dbReference type="GeneID" id="81622086"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.180:FF:000002">
        <property type="entry name" value="Endo-1,4-beta-xylanase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040997349" description="Endo-1,4-beta-xylanase" evidence="13">
        <location>
            <begin position="17"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="14">
        <location>
            <begin position="19"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5493488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="211" mass="22915" checksum="11AF74B86A16D842" modified="2023-11-08" version="1">MKVFATMAGLLAAAVAAPSSEHKLVARRNGIDYVQNYNSNLGAFSYNEGAGQFSMYWDQGVNGDFVVGLGWRTGSKEPITYSATYSAANSGSYLAVYGWINSPQAEYYVVENYGTYNPCSQAQSLGTLTSDGGTYQVCTDTRYNQPSITGTSTFTQYFSVRQNKRSSGTVTVNNHFNFWAQHGFGNSNFNYQVMAVEAFNGNGHASVQVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XL05</accession>
    <name>A0A9W9XL05_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_000077</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome b560 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793974.1">
        <property type="nucleotide sequence ID" value="XM_056929681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XL05"/>
    <dbReference type="GeneID" id="81619930"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000008">
        <property type="entry name" value="Succinate dehydrogenase cytochrome b560 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5494961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="190" mass="20327" checksum="DECAD5E0A5C09868" modified="2023-11-08" version="1">MFSQKLVQQSARRLAVQQPLAIQSMVRASPAAATLGLQKSVDKKALNRAVTSTAAEENSILAKQRMNRPVSPHLAIYRPQIGWVASGLNRVTGVALSGTLYLWATAYLASPALGWHVESASMVAAMGALPFAAKVLLKTIMALPFTFHSFNGLRHLMWDMGRGLSNNVIIKSGWTVVGVSVASALALAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLI4</accession>
    <name>A0A9W9XLI4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Membrane insertase YidC/Oxa/ALB C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_000358</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794255.1">
        <property type="nucleotide sequence ID" value="XM_056929962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLI4"/>
    <dbReference type="GeneID" id="81620211"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF66">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="12">
        <location>
            <begin position="138"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="406"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5495242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="502" mass="54863" checksum="609956AC157DAC54" modified="2023-11-08" version="1">MMGATGLGGPSKAAAMMRQRLATQPRSIRSISTLRPKRFPGHRGQLNLTSSVNSSWRYTALAAGPAAVRFNSTTPTPSPAPVAESTTPIDPSDVGFDISQLSEKIGYLKELGLDYGWGPSSMLQYVIEHIHVYTGLPWWASIVSAAVLVRLALFKPTMAASDTGARTHNARAIIDPIRHEMMKARMDGQTHQMQIKQAELKEIQNAHGIKPMKAFIPMLQIPLGYGIFRVVRGMTALPVPGLLSESALWLNDLTVADPYYLIPVINASCLYFTLKRGGETGTMDILQTSAGKALLIGLPSVSFAFMAFQPGALQLYFLSTGLLGLAQAFIINNNAFRNAMGMAIPKRATPAQNLTNLEQLQARLAELQKNPEKFRQQGVEASASAPASDASVSTIDRVQKNISNWSNKARQEVSEKWGEVKGNTTKNADGSVAAKPRLSAEAQRAAERYEQEAQAREAALREERNHARRAAHMRALAAEREKAQNMSKNFQSTGRKTPSRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLL1</accession>
    <name>A0A9W9XLL1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAFII28-like protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_000357</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794254.1">
        <property type="nucleotide sequence ID" value="XM_056929961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLL1"/>
    <dbReference type="GeneID" id="81620210"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="7">
        <location>
            <begin position="172"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5495241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="425" mass="44285" checksum="4C5942E0FD40BF63" modified="2023-11-08" version="1">MSSPPPYPNTSNPLKRPSLSSSASQPVGKKARMHPLRQTSFPNGLDGVDRSFGPTSDAGSVTGSFTGSIGGASADGVFAGAARGKKRGRKSKAEKEREREREDAMSARAGDGRLGSVDAEGSVRGGMGPGGAGGAGGGADDVEDDEDDDEGELLGREEGTTDTEAEKKNLAILVDAFNPQQSERYDLFKRAKLRKESLRRIVNHALSQSVPASVVTTVNGFTKVFAGEMIEKARTVQAEWADAFDASARAAFDAEEAAAERAAQARADAAAAAARAKAASQTPSGTPAPAANPGSVVNDIKKEPSDNDHNRLSSAPMNHNKPTPSPGPLSTTTSSHVSPSPSIAKPPPISAPSPAPPRPKREFRPPPNPHRGQLLPSHLREALRRYKRDGEGGGVGFSGLSMDNLGVKGSVTWSSGSVGGRRIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XME8</accession>
    <name>A0A9W9XME8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peroxin 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_000760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794657.1">
        <property type="nucleotide sequence ID" value="XM_056930364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XME8"/>
    <dbReference type="GeneID" id="81620613"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF4">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 20 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="318"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5495644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="40299" checksum="73962C7CB590AAAF" modified="2023-11-08" version="1">MGDALCGPSNALQNFQKHASVDRTLQQDRLISRQPANQGFRSQGTRDGLLDPEFAAFENSHGGLAPMVDLQHPAHFAHPTQHPAAVQSPPNWASDFQNLHISKSLPHQAQRASPIASSQTGWQNDFLSQQHQQHAVSQHVQAEQSINTPFRPSFGHHMPMYNNSMNMHHSYSQQAPIANTVPAEQFDESAFEAAFEQARADMQELQAPELTQTMETISQDQPLQIEETIMKEQEKITIGSDTIVKDDSTTVKNDADALARTAEHLLNSVRHEKDQKFQQSNFLALMRRIRDREVQVEGDEFREWIHIYANSHIEFSKQTAQSLHPGGPYYPGQSPERNTESDRASKEPKTSSSTLHSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMH5</accession>
    <name>A0A9W9XMH5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_000854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794751.1">
        <property type="nucleotide sequence ID" value="XM_056930458.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81620707"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="370"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="424"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="930"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="49"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1173"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1234"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1329"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1538"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1191"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1355"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1373"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1402"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1425"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1448"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1590"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1667"/>
            <end position="1676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5495738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1687" mass="183534" checksum="4149C21104943D9B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMJ0</accession>
    <name>A0A9W9XMJ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Elongation factor 1 alpha-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Elongation factor 1-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_000835</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the Dom34-Hbs1 complex, also named Pelota-HBS1L complex, composed of dom34 and hbs1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794732.1">
        <property type="nucleotide sequence ID" value="XM_056930439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMJ0"/>
    <dbReference type="GeneID" id="81620688"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000070">
        <property type="entry name" value="Translation elongation factor EF-1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="400"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="167"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5495719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="855" mass="92490" checksum="8BF2A60030A98941" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XML0</accession>
    <name>A0A9W9XML0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UPF0619 GPI-anchored membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_000865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794762.1">
        <property type="nucleotide sequence ID" value="XM_056930469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XML0"/>
    <dbReference type="GeneID" id="81620718"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF1">
        <property type="entry name" value="UPF0619 GPI-ANCHORED MEMBRANE PROTEIN C1322.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040949080" evidence="2">
        <location>
            <begin position="19"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5495749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="160" mass="17364" checksum="66D150847670FADD" modified="2023-11-08" version="1">MRLSFVSSVVAFTAATSAILVTYPPKGAKIDLGQPLTIKWDAVETDPAKFDLYVVNQAVNPSVTTLIASGVDTTKGSYTIPANDASLTGTDTGPPLAVGFLPSRNNSKSPVESLSRLQPPALLLDSNSHHLFFLFCDFVHFDFNAYIKLHEDTVYLCVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMR8</accession>
    <name>A0A9W9XMR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_000240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794137.1">
        <property type="nucleotide sequence ID" value="XM_056929844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMR8"/>
    <dbReference type="GeneID" id="81620093"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF113">
        <property type="entry name" value="POLY(A) RNA POLYMERASE CID11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="10">
        <location>
            <begin position="115"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="9">
        <location>
            <begin position="352"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="448"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="581"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="628"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="701"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="790"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="942"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="486"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="628"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="665"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="792"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="975"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1021"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1061"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1076"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1102"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1114"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5495124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1129" mass="124437" checksum="37DB1CE830F8CDA3" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN09</accession>
    <name>A0A9W9XN09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arginyl-tRNA--protein transferase 1</fullName>
            <shortName evidence="5">Arginyltransferase 1</shortName>
            <shortName evidence="5">R-transferase 1</shortName>
            <ecNumber evidence="5">2.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginine-tRNA--protein transferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_001112</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = an N-terminal L-arginyl-L-aminoacyl-[protein] + tRNA(Arg) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="Rhea" id="RHEA-COMP:10636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10638"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:83562"/>
            <dbReference type="EC" id="2.3.2.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the R-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795009.1">
        <property type="nucleotide sequence ID" value="XM_056930716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN09"/>
    <dbReference type="GeneID" id="81620965"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017137">
        <property type="entry name" value="Arg-tRNA-P_Trfase_1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037207">
        <property type="entry name" value="ATE1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="6">
        <location>
            <begin position="30"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="7">
        <location>
            <begin position="165"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5495996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="427" mass="49738" checksum="7F00B05BA9673925" modified="2023-11-08" version="1">MEPVDAERARQLSLFRPLGVSYYASSLVVRPNHYEELIHRGWRRSCGSRSGKLYYKQNLQRSCCPHYTMRLEANAYQPRRDQRKAINRWNKFVLGPEYIRKVTQLCPRTREEKRHRKSHFDLQSVVHEAEYSNLKRPIDPSTKRALEPAHKFEVNLEGDSVSQAKFDLFVKYQTKVHKEDVSRWKTKDFEGFLCSGIKRSPQIVNKINATEKKLGSWHQCYRLDGKLIAVAVLDLVPNGVSSVYIFYDPDFEQWEFGKLSAMREIAFAQENNYAYYYMGFYIHNCVKMRYKGNFRPQYILDPESYEWNPLDGELSKKLDAQTYVSLSRERTPQQARPFPDISSDVDETELSLFDINMPGVLTLEEVKALNLNEWSLLYHGSFVQMEDLVGWEDMPMDNPQSIKGIVAELAAVLGPKIVKDSAVVLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XNS7</accession>
    <name>A0A9W9XNS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin repeat protein nuc-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_000750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794647.1">
        <property type="nucleotide sequence ID" value="XM_056930354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XNS7"/>
    <dbReference type="GeneID" id="81620603"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047389">
        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14483">
        <property type="entry name" value="SPX_PHO81_NUC-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF23">
        <property type="entry name" value="DEPENDENT KINASE INHIBITOR PHO81, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="5">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="458"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="493"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="6">
        <location>
            <begin position="746"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5495634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1066" mass="119033" checksum="821175AB1CCF89BB" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ39</accession>
    <name>A0A9X0BJ39_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_009403</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785720.1">
        <property type="nucleotide sequence ID" value="XM_056938998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJ39"/>
    <dbReference type="GeneID" id="81629248"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000048">
        <property type="entry name" value="Proteasome subunit alpha type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5466674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="277" mass="29989" checksum="E74D95F036560B19" modified="2023-11-08" version="1">MADRYSFSLTTFSPSGKLVQIEYALNAVNQGVTALGIKATNGIVLATEKKSSSPLIDPPSLSKISLITPDIGMVYAGMGPDYRVLVDKARKVSHTGYKRIYNEYPPTRILVQDVARVVQEATQSGGVRPYGVSLLVAGWDEGIEPEAADMMKKDSESDKPTGKTGGIHKGGPSLYQVDPSGSYYPWKATAIGKHATSAKTFLEKRYTEGLELEDAIHIALLTLKETIEGEMNGDTIEIGIVGPPADHLLGFEGVEGAQGPRFRKLTKEQIEDYLTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ44</accession>
    <name>A0A9X0BJ44_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785709.1">
        <property type="nucleotide sequence ID" value="XM_056938987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJ44"/>
    <dbReference type="GeneID" id="81629237"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040965882" evidence="1">
        <location>
            <begin position="18"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5466663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="110" mass="12478" checksum="46200DF95922F43E" modified="2023-11-08" version="1">MGLLVFWNLSFVHYYDSDSDSDSDYDYDYDFCHYDYYCPLLILAICLHQPACHGRNFSECSSLGGAGLAIARIMGFFPSDIPRCIQQEMSAINLVCRPCAFPVIDRISLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ86</accession>
    <name>A0A9X0BJ86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alpha-ketoglutarate-dependent sulfonate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_009391</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785708.1">
        <property type="nucleotide sequence ID" value="XM_056938986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJ86"/>
    <dbReference type="GeneID" id="81629236"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF30">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_7G06030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="97"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5466662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="384" mass="43532" checksum="F870FC5869FF05EA" modified="2023-11-08" version="1">MPSSAPLIRSKLNGPHDQNGHNAHNAHKPEIPISYDINIPYVDVDKLSKIKTPYPQYLPSWDPVWYDPLPPFDYSDPALRVKDQSMRNLLTPNVTVNHIQPSIGSVVTGVQLNRLSDAAKDELALLISQRKVVAFPDQDLIDDGPAAQESFMRYFGKPNYQPVSGTVRGHPGFHVIHRDGNREEIARFLEQRTTTTLWHQDVSYEIQPPGYVMLGLLQGPEVGGDTVFSATDMAYKRLSPTLRSFLDTLKCVHTSSKMIAHTRLTGGLVRKDPVDTVHPLVRVHPVTGEKCLFVNAEFITKIQGMKEPEFKWMIDFLMNHVVTGHDFQARVRWQPRTVVMFDNRSTTHSAIVDYLDDEYGAKARHIFRLCALGEKPIPVYDEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BM66</accession>
    <name>A0A9X0BM66_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786679.1">
        <property type="nucleotide sequence ID" value="XM_056938297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BM66"/>
    <dbReference type="GeneID" id="81628547"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5472133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="113" mass="12456" checksum="17B6725EA6120930" modified="2023-11-08" version="1">MAPFQFEEPSDIVRRDMAIAWSPLVLPALSIIEMLVGMVCWYSSKTRRGNGAWMAIYSAVLLSFGIGLSAWIFRKRPSTNETRSANEEKVPPAEVTPNSKAVVPEPEGMTAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BM71</accession>
    <name>A0A9X0BM71_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008621</name>
        <name evidence="3" type="ORF">N7539_008717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786598.1">
        <property type="nucleotide sequence ID" value="XM_056938216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BM71"/>
    <dbReference type="GeneID" id="81628466"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5472052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5472148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="48751" checksum="25C17C66AC2B9C3C" modified="2023-11-08" version="1">MRLLDSRREKRGTHGEPNSGRMMIMEPPGHEPYTEDSVNKPAEAIPVVADRLGVFAASSQSDVSGVHPHQIRAYEASPTPSQTLSIHMNRAHYPKPPIASGGSDVFACKCRHIDRDLKPYVCLSETCTEGHPTFSTSDEWFRHMELHGHRWQRQNYLLTAWICTICDFKSNIYRNSEALHVHLKQSHADEFTSKQLQAFSRQSRIAQPRARNECLLCCCLVEETPQDHGGVVFPKRRKGSSKQQTAKNARKTHETITAVRPSPQANFSDTSSDSDDANPPSHRPQTQVHARALARHIAAHLQGLMLLTLRFAALQTDDAVLDDDAKSDLVDTDDGASASKGMDIGILSDFDSVADVSTEVLRGDEILRFDPDLVGDDRTLSQSQTAISVSRKSRDHVMASQPKMIFSYSESGSQGPFSRERGNHLQYSNSSHNEYVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BMX7</accession>
    <name>A0A9X0BMX7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome monooxygenase lcsI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_008187</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786879.1">
        <property type="nucleotide sequence ID" value="XM_056937787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BMX7"/>
    <dbReference type="GeneID" id="81628037"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5475121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="529" mass="58979" checksum="313A55DAAEB1DD69" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BN25</accession>
    <name>A0A9X0BN25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc-regulated transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_008322</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787014.1">
        <property type="nucleotide sequence ID" value="XM_056937922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BN25"/>
    <dbReference type="GeneID" id="81628172"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000006">
        <property type="term" value="F:high-affinity zinc transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF32">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="160"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5475256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="375" mass="41170" checksum="A1EE44C61E9408EE" modified="2023-11-08" version="1">MATFDPHNVNLDTVDQSQIICYLALGHNEYNGSLGARVSSIFVIGIVSSVFTFFPVVAKRAPRVRIPLYVYLFARYFGAGVIIATAFVHLLDPAYSRIGSQSCVGMTGHWGDYAWCPAIVLFSLMMVFLLDFGAERYVEKKYGICREDPEPIMTTGTHVHQVEAQNPDRPPPHPNPHPHPHFESPSAPSSLETKEKKANDIETLSCDDSIMVRSFRQQISAFLIMEFGVIFHSVIIGLNLGVTGNEFATLYPVLVFHQSFEGLGIGARMSAIPFPRDSPLPWLLCAAYGLTTPIAIAVGLGVRTTYNPDSFTAMVVAGVLDAVSAGILIYTGLVELLARDFLFDPHRTTDDRRLTFMVVSLLLGAGIMALLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNA2</accession>
    <name>A0A9X0BNA2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5474987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786745.1">
        <property type="nucleotide sequence ID" value="XM_056937653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNA2"/>
    <dbReference type="GeneID" id="81627903"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5474987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="39376" checksum="064A50B60F965775" modified="2023-11-08" version="1">MDAATTVLSLVASAATNLAIATPAPSSSPYFAASVSSSPTSTMLYSYNATASGDDSNGEDDGECKLLGPFSLLVQAALGALALSSLVYKRWRERPQRPLKVWAFDASKQVFGSGLLHLANLLMSMFSAGEMQVRKSYKPNPCSIYLLNLGIDTTLGIPILILILRLLNYIAFYTPLANPPESIESGNYGQPPRAIWWLKQSMIYFVGLLGMKVCVFFLISLFPFIIKVGDWALGWTEGNTALQIAFVMLLFPVIMNALQYYIIDHFIKKHGSPDAYTAPNMPDDEDDAQRRAALLDGYDDAYSSDSETEESGSKPTVTVSEANPKTKASELPGSEEMLTEDFSPVPPYEPPSSSSSRSERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BP34</accession>
    <name>A0A9X0BP34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Peroxisomal biogenesis factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_007527</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787927.1">
        <property type="nucleotide sequence ID" value="XM_056937128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BP34"/>
    <dbReference type="GeneID" id="81627377"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF4">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="17">
        <location>
            <begin position="84"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="406"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5477383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="480" mass="54159" checksum="A56B277474901CF3" modified="2023-11-08" version="1">MSSTNFAAAQERILERRRLREAEAQARRVEQRRSSLINSTALQRLPYPLSRVPGVGLSIWDSIRGRDGTRPAFRVGQVDAELLDEELLGLMKNQVGDALKYFGPQMREEWSHEILFALRAILFKLSIWDHNASYGAALQGLRYTDSRSKGPVHSAPTKWQKMMYGLLTVGGRYAWDKWESWLVGQEGAYEEPSQEIRMFSRLTDIVSTTHSVAALISFLVFLVNGRYRTLVDRLLRIRLTPPSAQASREVSFEYLNRQLVWHAFTEFLLFLLPLVGISRWKRWISRAWRRTVKSIKSASDDEEDTNDQGELAFLPERTCAICYRDQNPAATSESEILAASAAAGISGSAQTDITNPYETIPCGCVYCFVCIVQKLEAEEGQGWVCLRCGELVKKCRPWNGDVLEETRSQPGTGKIVGFAIDDRPNGPPADPEEEESLSKPSALGNVTADEALHSNQWNVDEKHDDEIEHRNGMNGFADRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BPH6</accession>
    <name>A0A9X0BPH6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_007600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788000.1">
        <property type="nucleotide sequence ID" value="XM_056937201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BPH6"/>
    <dbReference type="GeneID" id="81627450"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.70:FF:000006">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.70:FF:000007">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5477456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="201" mass="22793" checksum="2E4DB57F8AAD2246" modified="2023-11-08" version="1">MGISRDSRHKRSATGAKRAYYRKKRAFEKGRQPANTRLGTKRIHLVRTRGGNQKYRALRLESGNFSWGSEGVARKTRVIGVSYHPSNNELVRTNTLTKSAVVQIDAAPFRQWYEAHYGQSIGRRRQQKTAETTEEKKSKSVTKKQAARYAAQGKVEGAIERQFESGRLFAVVSSRPGQSGRVDGYILEGDELAFYQRAIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BS58</accession>
    <name>A0A9X0BS58_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_006664</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788200.1">
        <property type="nucleotide sequence ID" value="XM_056936265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BS58"/>
    <dbReference type="GeneID" id="81626514"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000006">
        <property type="entry name" value="mannose-P-dolichol utilization defect 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="265"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5480770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="301" mass="31641" checksum="977BD8452084E6BC" modified="2023-11-08" version="1">MDVLQKSVVTPLQPVLKPIVEALPQPVHDAIISLISAPCHKALVLDLNLVEDSACTSLAISKALGIAIVGASAVVKVPQILKLINSRSSAGVSFASYALETASLLITLSYSVRNGFPFSTFGETALIAIQDVAIGVLVLTFAGRSVAAATFVAIVAAAVYALLFDQNLIDGQTMAYLQTGAGALGVASKLPQIYAIWKEGGTGQLSAFAVFNYLFGSLSRIFTTLQEVEDKLILYGFIAGFSLNLILAAQMVYYWNSPAPKQKTASSAKIAEKPVPTSSFAQSSSASPRPGSKTPTTRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSI2</accession>
    <name>A0A9X0BSI2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_007008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788544.1">
        <property type="nucleotide sequence ID" value="XM_056936609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSI2"/>
    <dbReference type="GeneID" id="81626858"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF25">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5481114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="626" mass="70495" checksum="BFE0D792864D84AA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BT14</accession>
    <name>A0A9X0BT14_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_006427</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="14">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788953.1">
        <property type="nucleotide sequence ID" value="XM_056936029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BT14"/>
    <dbReference type="GeneID" id="81626278"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23791">
        <property type="entry name" value="UBCc_UBE2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000068">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-20 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="16">
        <location>
            <begin position="32"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="13">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5482981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="181" mass="20154" checksum="F7EFF51EAA65F23A" modified="2023-11-08" version="1">MDYTMEDTQNSAPESLETTKLSGAGQRNETQSVTKRLQAELMQLMMSPSPGISAFPNADGNLLAWTATITGPTETPYEGLTLKLTFDFPNNYPYSPPTVLFKTPIYHPNVDFSGRICLDILKDKWSAVYNVQTVLVSLQSLLGEPNNASPLNAQAAELWDSDQAEFKKHVLSRHRDLDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUF7</accession>
    <name>A0A9X0BUF7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit Hsk3 like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789570.1">
        <property type="nucleotide sequence ID" value="XM_056934376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUF7"/>
    <dbReference type="GeneID" id="81624625"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042332">
        <property type="entry name" value="Hsk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013183">
        <property type="entry name" value="Hsk3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08227">
        <property type="entry name" value="DASH_Hsk3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5484786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="16433" checksum="96BEC6EEC9AEDBF1" modified="2023-11-08" version="1">MPLNPAHHRNDSNSHSHSHSTYSYPRASMAPPNTSSTFQQSHYQTQAHPHHQHQHQPMSSSASGSVSMSAAKARQYAQLQTQLAQLNANLADTQNLLRMTAVQAGDMRFLGGYMGALFMGSAKVLGEEGVKGKSGSGEGAGEAIVKKEDSEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUF9</accession>
    <name>A0A9X0BUF9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_005930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789404.1">
        <property type="nucleotide sequence ID" value="XM_056935532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUF9"/>
    <dbReference type="GeneID" id="81625781"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11404">
        <property type="entry name" value="bHLHzip_Mlx_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057072">
        <property type="entry name" value="bHLH_INO4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23181">
        <property type="entry name" value="bHLH_INO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="353"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="201"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5484134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="428" mass="46576" checksum="1E2AAC0D52672E8A" modified="2023-11-08" version="1">MERSAAEVGPEQTPPVPTGPFGYAFLSPMDTPFEQPPALPPGLPLLDDNESSMLDNFFSTMNTNNLANDFWLRGHHDKPPGLDFGWNQELPPTFEGSTTSLSQSSFVTPNSKANVVGGGGDTNADIYAAASLLFPNETHGGHLGPALAQHTFTGQPLNLGVAHGRRDSRNPVHAVASSSSSSRPRVPTGFHTSEMLFDVRDPIPVDQHPSRKARGLHWGSDGSFMDQGYVAPPDQPDMETRTRELLGQLDCFEPQDSAATTRAPSPERTTQSNNTSAAHHSTGDENDSHPRKRQRTIKGKSDSPSEDEEPGSQPNKSRSSSIAKGRRASTDGSRKARVIQGAKATRENLSEEQKRTNHILSEQKRRNLIRQGFDDLCSLVPSLRGGGFSKSAMLTQAADWLEDLLRGNELLRSQLTDMKSINGLVMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUG5</accession>
    <name>A0A9X0BUG5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetylornithine transaminase</fullName>
            <ecNumber evidence="5">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_005945</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789419.1">
        <property type="nucleotide sequence ID" value="XM_056935547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUG5"/>
    <dbReference type="GeneID" id="81625796"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002325">
        <property type="entry name" value="PRK01278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5484149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="482" mass="51715" checksum="F5C4233E033E9A23" modified="2023-11-08" version="1">MVALRVAARRLPCAARSSPSFPSLVSVSQRRFAATSNAAQDVRQQVQKESTLPNPDPAPDSLTASFINERTPFMVPTYVRPAPMMMKGQGCYLWDMENRRYLDFTSGIAVNSLGHCDPEVAQIVAEQAETLVHASNLYHNPWTGALSQMLINLTRESGAMRDASQVFICNSGTEANEAAIKFARKVGRSIDPSGAKHELVSFQNSFHGRTMGALSATPNPKYQTPFAPMIPGFKYGNYNDVEQLQTLITENTCGVIVEPIQGEGGVNVAEPEFLVALRKRCDEVGAVLIFDEIQCGLSRTGSFWAHGHPSLAPASGEAAHPDILTTAKALGNGIPIGATIVASKTVASHIKTGDHGTTFGGNPLACRAAYHIVARLADSELQRGVEKKSAVFTAGFQALREKFPNAISEVRGRGLILGLQLSPEFTSKAADIITAARERGLLIITAGEGCIRFVPPLTITEEQIQTGLNILEQAMASVVSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUP7</accession>
    <name>A0A9X0BUP7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_005059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789855.1">
        <property type="nucleotide sequence ID" value="XM_056934661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUP7"/>
    <dbReference type="GeneID" id="81624910"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058664">
        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF97">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26335">
        <property type="entry name" value="ARB_00930_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040953330" description="Beta-lactamase-related domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="104"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-like ARB-00930-like C-terminal" evidence="3">
        <location>
            <begin position="441"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5485071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="582" mass="62467" checksum="A358FBE04AF17311" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BV57</accession>
    <name>A0A9X0BV57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_005630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790426.1">
        <property type="nucleotide sequence ID" value="XM_056935232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BV57"/>
    <dbReference type="GeneID" id="81625481"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="9">
        <location>
            <begin position="14"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5485642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="289" mass="30710" checksum="52CC2DBA459819B4" modified="2023-11-08" version="1">MPPSATHQIPNTLPLTLIVATTPVRAASTSSPNEAATRLGIGLKGTLPWPRIKTDMSFFARVTSRAPAAGTTNAIIMGRKTYFSVPKHLRPLAKRISVVVTRDTTGSVRDEVMKDLEARKAKLAEAAKVKAESASPSESTSRDVGDEPVTDALVTRSLEMALSELEASYGSSGKLGKIYVIGGAEIYGLASRLKVVDGQDRKRPVRIVLTNVVRKTGGQGDAAAAAAAAAATEGYECDTFFPVEGLGTGTEWRTATSVEVSEWVGETVTGEWIRDGDVEVQMVGYERAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BVF7</accession>
    <name>A0A9X0BVF7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790409.1">
        <property type="nucleotide sequence ID" value="XM_056935215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BVF7"/>
    <dbReference type="GeneID" id="81625464"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="74" mass="8575" checksum="C12A2B6E49082E7D" modified="2023-11-08" version="1">MPYLSPRKAAETKKSTMDEERANLNRRAESIEDKNTRIKALLEEAEVLAQDMLSTLEAHRKRLEEADEKMDKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXY0</accession>
    <name>A0A9X0BXY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_004171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791314.1">
        <property type="nucleotide sequence ID" value="XM_056933773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXY0"/>
    <dbReference type="GeneID" id="81624022"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5489281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="126" mass="14103" checksum="D8A7188629AC428A" modified="2023-11-08" version="1" fragment="single">ALFVPHIQHSNKMSPIQPTRRLLIFQETRNPLNTAEVAYLPVNKLGLPICGNGPDLPSILELPLHILKVFTEIFNQPKYKGWAILSAGRYHDTSEEGKFYAVVLEQTPLPGQVQDHGMRDSGTFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXZ1</accession>
    <name>A0A9X0BXZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_004155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791298.1">
        <property type="nucleotide sequence ID" value="XM_056933757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXZ1"/>
    <dbReference type="GeneID" id="81624006"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF1">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5489265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31038" checksum="5E11A7F9BFF9FDBF" modified="2023-11-08" version="1">MSTFVTVEGVPNVRDIGGYACAPPVSVVHDEIATDAQWTIRTGLLFRAAQPSQITVAGVDTLTKTLGIQAVFDFRSESEIDLVRQRYPNSLLDIPGTTRHAVPVFQAGDYSPVSLAKKYGVTGKPSESERDQQVSRPGFVKAYEAIARSAAQTGSFRAIMQHLLHDPAAAILFHCTVGKDRTGVFSALILRLCGVADEDIVADYALTTQGLGVWREHLIARLLQKGDATTREQAEAVISSDPTDMSVFLRDVVDAEFGGARKYFTDLCGIPENDLDQIISRLVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY97</accession>
    <name>A0A9X0BY97_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791674.1">
        <property type="nucleotide sequence ID" value="XM_056934133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BY97"/>
    <dbReference type="GeneID" id="81624382"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14372">
        <property type="entry name" value="CUE_Cue5p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000064">
        <property type="entry name" value="Similar to CUE domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041807">
        <property type="entry name" value="Cue5/Don1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="78"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="446" mass="49033" checksum="2ED0669931B626D1" modified="2023-11-08" version="1">MAEENKSPPPSKPSAAIVPTSPRAESPTTARPLDFDDEPQESGVVTSGTNASSGQQASQTTTETPPAAPPKPPRPLSPREQSLNTLKEAFPSIDPAVVKAVLTASNWNVERAFNALLGMTDPAAQEEMVPPPKPPRPQRVPTSTTQRQLEDDERYARQLAEHYNTPGDGRRRPAPGWENDPRYRQPRGSEDSNDKDYSFFDGTVRYFPVMILEKRKHGLTSISFTDDLPVIRENFKKGFMETQTKVNAWFGNLKKQLNGEDDEEEEHARASQRYEQQTSTFGRPRRSGELGRRSGDRERYDADPQLLSDDFSALELRDGEAPPARPPRPGGANLNKAPSPSSGRRVSFQEGPATEIDNLYDASAPIKRNPTPSGKPSKWQPLATVEPSPVAENDPFSLGDSDDEKDVKAKEQTTVSESDQIKKATAEAMSGEIGSAADNQKKDSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYG3</accession>
    <name>A0A9X0BYG3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteinase inhibitor I78</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791391.1">
        <property type="nucleotide sequence ID" value="XM_056933850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYG3"/>
    <dbReference type="GeneID" id="81624099"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.10">
        <property type="entry name" value="Trypsin Inhibitor V, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021719">
        <property type="entry name" value="Prot_inh_I78"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600:SF1">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11720">
        <property type="entry name" value="Inhibitor_I78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="8948" checksum="260BE97270EAB45A" modified="2023-11-08" version="1">MPLVVPGVNSDMGDKSEWVNKLMGKKISDSTSDEVSFAKKDLPQSHRVLKPDDMKSMDHNPDRLNVHVDHDGTVRNVTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYM3</accession>
    <name>A0A9X0BYM3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome c oxidase assembly protein COX19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_004262</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the assembly of mitochondrial cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the COX19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791405.1">
        <property type="nucleotide sequence ID" value="XM_056933864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYM3"/>
    <dbReference type="GeneID" id="81624113"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051383">
        <property type="entry name" value="COX19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="7">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5489372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="98" mass="10787" checksum="6A2BFC4B794EA227" modified="2023-11-08" version="1">MSFGAPGGGSVNYKPTPPERGSFPLDHEAAEYTRTGECKHIISGYLKCIKLNRGTNDEACRKLAKQYLACRMDKYVVTGLFCSSPAGSYFRSVADENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYS7</accession>
    <name>A0A9X0BYS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dehydrogenase citC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_004563</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791706.1">
        <property type="nucleotide sequence ID" value="XM_056934165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYS7"/>
    <dbReference type="GeneID" id="81624414"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF210">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5489673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="626" mass="67465" checksum="D4B549E9086C18AE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYZ5</accession>
    <name>A0A9X0BYZ5_9EURO</name>
    <protein>
        <submittedName>
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    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875:SF2">
        <property type="entry name" value="ACR183CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875">
        <property type="entry name" value="OS09G0542200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="1">
        <location>
            <begin position="18"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="207" mass="23512" checksum="DE00166BE51CBF96" modified="2023-11-08" version="1">MSVPPKYAGLKLFRAIPSEAQHTLEIYLDYVCPFSAKMFKTFYADGNPVAKNYSSRLQVIFRLQIQPWHPSSTLTHEAGAAVLRAAPEKFWEFSAALFKQQKDFFDVNVVNETRNKTYERLARIAGSVGVDEKKILDMLVIPETAVNAESLNAGNQVTDDIKWMTKTNRVIGVHVTPTVFFNGVEERGISSSFTEAQWQEWFEKNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZU9</accession>
    <name>A0A9X0BZU9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792691.1">
        <property type="nucleotide sequence ID" value="XM_056932732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZU9"/>
    <dbReference type="GeneID" id="81622981"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="401" mass="45357" checksum="4118CFE04C0792DD" modified="2023-11-08" version="1">MLRLRQLFRSQSRSPLSHLGPRQPPHQPAAIRHVRFRRPWFRSFLGKAILYGTAFHLWSSFVLVRFDDDDTQTDKAASKQRLDTRTLQTAAATRNDALADEESGEDDSVFIPLTWSWMEEGDYYRASDPEWQEFVKISKDKKKLQELREELAALVLKTASDLMAPALGSPLTLTGYWLVHTFPSRAPPQYVRAGIELDDEGISLVTKPLDQDIGDRIHSAMNPIHVALAIKDAYYLVVRRKIARLLSSESQPDNGDLRGKFILSHGEPNTISTREQSSTDPSMSEQPSQNILPNTEPELHPSSIISSLQRLPLPDLGPGSDLQLASMAFRLRLDEYKREQGSRTPRRGTFFISGPVGVKGPDGYCRFEVRGEYDPATSAWRTVQMDLMDANPRKQKPARSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0A9</accession>
    <name>A0A9X0C0A9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TATA-box-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_002014</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793648.1">
        <property type="nucleotide sequence ID" value="XM_056931617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0A9"/>
    <dbReference type="GeneID" id="81621866"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5493268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="257" mass="27908" checksum="5D201CC2B1034611" modified="2023-11-08" version="1">MDSLTTHPSNAQQARAFTSPSSLSFPGGAGDLTPPSLEKENQGAQGQQYAGANATDGNGVTPATPAATPGAANQNNPSGIVPTLQNIVATVNLDCRLDLKTIALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARIIQKLGFNAKFTDFKIQNIVGSCDIKFPIRLEGLASRHHHFSSYEPELFPGLIYRMMKPKIVLLIFVSGKIVLTGAKVREEIYSAFELIYPVLSDFRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0B8</accession>
    <name>A0A9X0C0B8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793797.1">
        <property type="nucleotide sequence ID" value="XM_056931766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0B8"/>
    <dbReference type="GeneID" id="81622015"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="2">
        <location>
            <begin position="29"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5493417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="179" mass="19310" checksum="CE21292DF6B59F27" modified="2023-11-08" version="1">MPSKPTQSSPAKGNAKLQGYTSDLAEQQENAFLAMCLRCLDLETKKVDAGAVAKALGYSNAKSAGNRFSAMRKKYNLHIEFSYPRGDAKPGTKTSPNRVQKTHRKRGSKTKADIHADTQHGEKPETCEPETEEKDDDLLDGPLLSDEQGPGDMTLNAPNLEDSDEDGGVALGLPPTPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0H6</accession>
    <name>A0A9X0C0H6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_002062</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793696.1">
        <property type="nucleotide sequence ID" value="XM_056931665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0H6"/>
    <dbReference type="GeneID" id="81621914"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5493316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="161" mass="18685" checksum="7DA121A6ECCB645F" modified="2023-11-08" version="1">MPISYLILLSRQGKVRLAKWFTTLSPKEKAKIIKDVPNFRFAILAVPSEQFTDRNPLLPDSKVVYRRYASLFFIAGCASTDNELITLEIVHRYVEQMDKYYGNVCELDIIFNFQKAYFILDELLLAGEMQESSKKNVLRCISQQDSLEDMEVEEDVVTKIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0Z8</accession>
    <name>A0A9X0C0Z8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_002255</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793889.1">
        <property type="nucleotide sequence ID" value="XM_056931858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0Z8"/>
    <dbReference type="GeneID" id="81622107"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000005">
        <property type="entry name" value="TfdA family taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF20">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="43"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5493509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="355" mass="39261" checksum="178C7C38B7E7AB22" modified="2023-11-08" version="1">MPSAQVDTPSAAGDNIRGGNPKAQTRCLKPLVYSGSLEKYTYADVTPVIGREFKGLQVTELLSADDSVIRDLACTISQRGVVFLRDQEVTPEQMKQFCLRLTDIAGCPESSGLHVHPLTEEGSELGDQISVISSEKQKKGGGLTHQLSDVSRFASAGWHTDISFEAVPSDYAMLKIHTLPPTGGDTLWASGYEIYDRLSPSMQTFLEGLTATHDANFFHDEARRLGNPIRKEARGSPLNLGENLQAVHPVIRTNPVTGWKSVYVNKGFTKRINGVTKDESDMLLAYLFNLVTQNHDAQVRFKWRKNDLAVWDNRSMWHCATYDYAEARAGDRVASLGEAPYLDLSSKSRREALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C268</accession>
    <name>A0A9X0C268_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_000292</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by PDX2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794189.1">
        <property type="nucleotide sequence ID" value="XM_056929896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C268"/>
    <dbReference type="GeneID" id="81620145"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00343">
        <property type="entry name" value="pyridoxal 5'-phosphate synthase lyase subunit PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="12">
        <location>
            <begin position="12"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="9">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="246"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5495176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="305" mass="32365" checksum="6D564A2C51F1C979" modified="2023-11-08" version="1">MVQGNGTSSNDFTVKAGLAQMLKGGVIMDVINAEQARIAEEAGAAAVMALERVPADIRVEGGVARMSDPAMIKEIMEAVTIPVMAKARIGHFVECQILEAIGVDYIDESEVLTPADDVYHVTKSTFKVPFVCGCRNLGEALRRISEGAAMIRTKGEAGTGDVVEAVKHMRTVNSQIARARAILQNAADPEPELRAFARELEAPYELLRQAAELGRLPVVNFAAGGVATPADAALMMQLGCDGVFVGSGIFKSGDAKKRAKAIVQAVTHHKDPKVLAEVSEGLGEAMVGINVQRMPEADKMAGRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2H8</accession>
    <name>A0A9X0C2H8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_000784</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794681.1">
        <property type="nucleotide sequence ID" value="XM_056930388.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81620637"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.10">
        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032353">
        <property type="entry name" value="AZUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042556">
        <property type="entry name" value="AZUL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16558">
        <property type="entry name" value="AZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="964"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="391"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="449"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1123"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1176"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1128"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5495668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1370" mass="154834" checksum="CEF82181741303ED" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2N9</accession>
    <name>A0A9X0C2N9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794684.1">
        <property type="nucleotide sequence ID" value="XM_056930391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2N9"/>
    <dbReference type="GeneID" id="81620640"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="100" mass="10801" checksum="0B22E3554DE9003C" modified="2023-11-08" version="1">MISDDCIKLTGDVDVEFPPQTLEARAASIAVAAVEHSSPIGPETLRYGGTLAFHRAKPERHTSIDSPGFDSEMLRFAPQVDGLPSKGTPEEELPRWRAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2R7</accession>
    <name>A0A9X0C2R7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
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        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5466594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="235" mass="25202" checksum="4C51A8ADB2E12435" modified="2023-11-08" version="1">MSGSPSTKAGKNMSSRLLTMKRAAASAAAKEPQIPAATDDDDKRAKKPRLSTEAEGSRTSQSDLEAMSAAMAAEEAKRREAIARQAAEAGESEWVLDIPYAPTDPQPIVLSADSLDAEDDLPQGGRRAYGNFTRKKPSAPVATTKAEASADDEDEDDESDYESGSLINPADPEAVAAHIEKLRQKALAKEQRRKDALAHAERKRLSGLTSISGSQKATYPSMGSQSAKKKKKRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKV9</accession>
    <name>A0A9W9WKV9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_008951</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785923.1">
        <property type="nucleotide sequence ID" value="XM_056938546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKV9"/>
    <dbReference type="GeneID" id="81628796"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5469333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="63" mass="7582" checksum="564A38346C9AA51B" modified="2023-11-08" version="1" fragment="single">HSDLATRLEEEDDWGVWPLKPDHYRAPEVILGNVWRMPADIWNLGFLLWDMIEGEELFRHIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTP2</accession>
    <name>A0A9W9WTP2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Beta-hexosaminidase</fullName>
            <ecNumber evidence="3 9">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_008361</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3 9"/>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787053.1">
        <property type="nucleotide sequence ID" value="XM_056937961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTP2"/>
    <dbReference type="GeneID" id="81628211"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF26">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040738847" description="Beta-hexosaminidase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="13">
        <location>
            <begin position="24"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="12">
        <location>
            <begin position="182"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5475295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="601" mass="67089" checksum="6634A542E4DFAFF7" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTW2</accession>
    <name>A0A9W9WTW2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="5">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_007727</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the NADPH-dependent formation of L-aspartate 4-semialdehyde (L-ASA) by the reductive dephosphorylation of 4-phospho-L-aspartate. Mediates the second step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-aspartate 4-semialdehyde + phosphate + NADP(+) = 4-phospho-L-aspartate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:24286"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787193.1">
        <property type="nucleotide sequence ID" value="XM_056937328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTW2"/>
    <dbReference type="GeneID" id="81627577"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18130">
        <property type="entry name" value="ASADH_C_arch_fung_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02315">
        <property type="entry name" value="ScASADH_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000200">
        <property type="entry name" value="Aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000016">
        <property type="entry name" value="Probable aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051823">
        <property type="entry name" value="ASADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006416">
        <property type="entry name" value="PRK08664.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718:SF1">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000148">
        <property type="entry name" value="ASA_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="16">
        <location>
            <begin position="9"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="15">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000148-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5475440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="372" mass="40072" checksum="0A8ABCB8221B2AF4" modified="2023-11-08" version="1">MAGSYPKKKCGVLGATGSVGQRFILLLADHPFLELHAVGASERSANKKYKDAVRWKQSAPMSERLSNLVLRECKAELFTDCDLVFSGLNSDIAGETGHSLTIGAEMAFIKAEIPVFSNAKNYRKDPIVPLVVPTVNPSHMDLIPHQRKHFGLKKGFLVCNSNCAVIGVVIPFAALQAKFGPVEEVEVFTEQAISGAGYPGVPSLDIVDNVIPFISGEEDKLENEAQKILGSLNDDASAFNEQSGLRIGATCTRVGVTDGHMAFVSLRFKNRPAPKAEEVAQAMRDYQSEAQKLGAPSAPELAIKVFDEPDRPQPRLDRDISKGYTVSVGRIRDGAEGGYFDIRFAALSHNTVIGAAGSSILNAEVAVIKGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTW9</accession>
    <name>A0A9W9WTW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="2">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_007702</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787168.1">
        <property type="nucleotide sequence ID" value="XM_056937303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTW9"/>
    <dbReference type="GeneID" id="81627552"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF26">
        <property type="entry name" value="FAD-BINDING 8 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040822522" description="ferric-chelate reductase (NADPH)" evidence="11">
        <location>
            <begin position="23"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="170"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5475415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="400" mass="44877" checksum="F918E41832C0DDA4" modified="2023-11-08" version="1" fragment="single">SSSNGRILGFLTLLGINGFCNTFKTYDLEDAGQRAARLALVNLIPLFLGGSHDFAAHSLGFSLDVYSFLHRSFAVAALLEAVIHVAIVIRTTSTSLNIDMNVYGIVAASILLSLFVLPFVRRRVYEIFLVAHKACAIAVVYAIWQHTRSAPGYIWLFSALYALILTLTVMMQFLRTLYQNVTVEKSLAKVNIQCYPGDTTQLRVLLPRPWKVRAGQRVNLSVPHVGIQYALQSHPFTVAWWETDRQGKARSFTILLRPQSGFTQKMVERLRPDHSYKAWTSGLYGPKSINWHPNSRIGNYGHVFFATTGIGIAAQLPYIKELLDGHQNATITTQKICLIWQLDQIGDWESARDLLQCLVRQDNGYVSFVPSVAQHPVPFNTSYYVITNPDATSLSLRRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTZ2</accession>
    <name>A0A9W9WTZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L21-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_007716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787182.1">
        <property type="nucleotide sequence ID" value="XM_056937317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTZ2"/>
    <dbReference type="GeneID" id="81627566"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5475429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="160" mass="18337" checksum="B660A89CF33113CC" modified="2023-11-08" version="1">MPHSYGLRAGTRYAFSRNFKEHGMIRMSTYMKTYRVGDIVDVKVNGAVQKGMPHKVYHGKTGVVYNVTKSSVGVLLYKRVNNRYLEKRINVRIEHVQHSRSREEFINRVKENALKKREAKEKGVHVHLKRQAVGPREGHFVSAAGNAPETVVPIPYDTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU07</accession>
    <name>A0A9W9WU07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_007804</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787270.1">
        <property type="nucleotide sequence ID" value="XM_056937405.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81627654"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="537"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="115"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1230"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1263"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1297"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5475517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1371" mass="152702" checksum="E29F0CAB66F456C6" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU42</accession>
    <name>A0A9W9WU42_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786890.1">
        <property type="nucleotide sequence ID" value="XM_056937798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WU42"/>
    <dbReference type="GeneID" id="81628048"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5475132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20252" checksum="50DED9502A0A72F1" modified="2023-11-08" version="1">MCTREQYTVGWICAITTEYVAAKQILDTRNTYTFGKVGSHNVVISVLPIREHRISSAARVAEEMIHNFPNLRIGLMVVIGGGAPRPKHDIRLGEIVVSTPHNDHGGAFQYDFGKTMRHQIFQQTGFLDQPPTVLRAAVCELRAQYMSDGHAVDDVVSKILEKEPRLRRDFERPDPATDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUI7</accession>
    <name>A0A9W9WUI7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5476985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787529.1">
        <property type="nucleotide sequence ID" value="XM_056936730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUI7"/>
    <dbReference type="GeneID" id="81626979"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008402">
        <property type="entry name" value="APC_su15/mnd2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05841">
        <property type="entry name" value="Apc15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5476985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="406" mass="45043" checksum="FE83D2495986064E" modified="2023-11-08" version="1">MLSLPFLAPQDSHELWFGPSNPYRSSSQHPSSEAHLNHPHRRTNAQTTTSSSSSNPLRRSEAFHAFRTSDLTLSTLQTEERNLRARKTTIACFGSSWIRPAGCAKTMLGMKEEEAEREEALAALAAEQEAAAMAAAAEGMTMGEGEEGGDEEGMERDLDDEIPDADAEEGLVEEGEEGLEEDEEGYMERDLDDEIPEGYPNDGYGDESGLYAEEVDEDFDNQPDLDADVPEAEDEDEDEDEEGSELDEYEDAVEEGDITRDLDDEIPDADADEEEEEEGEWQHTDTEDEYEDEENEENEGQNISSSGPGSITRPRTGNFRTSTPNRHGLPTPPFMRRPRPSGAGETEAQRRFINRWSGGGDAFDSSSMLYEEDDLRASMTSQGSGRPSGFGRRYPRRIGGPRDSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUP8</accession>
    <name>A0A9W9WUP8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_007983</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787449.1">
        <property type="nucleotide sequence ID" value="XM_056937584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUP8"/>
    <dbReference type="GeneID" id="81627833"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08049">
        <property type="entry name" value="TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="8">
        <location>
            <begin position="55"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor TFIID subunit 8 C-terminal" evidence="9">
        <location>
            <begin position="173"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5475696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="348" mass="39167" checksum="01533B4E1DC90658" modified="2023-11-08" version="1">MATSSQIKRSPNHLEAKDVKRQRQFYHHHHRLLEPVVLPQACEPALQDDDNVDQMMNRTLGLALRHAGFDLADPAALNSFRSATEEYLLHVAKFVRQSMLSSRRLQPIPQDFDYALNHHRITPDDLRPYLKTPPTGIHTRVLPPSPPPEDEVKRKLPFLNSLRHEESETNRSYVPKHFPDFPSKHTYSSTPVFTERDNDPRKIRERAAEDGRHGEEALRKLASAAYRNSPTGVSGRDKKLWGRRAESMETMFEKTIRGLTKKLQKDPLSVPGANVVSAGGSAMEIDSGLVGDADKSRTKLLGDLDMGPIVNCERDYWRRTTAASSRNVEDKVVKSKSGLEGVNGLIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUV2</accession>
    <name>A0A9W9WUV2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pathogenesis associated protein Cap20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_007297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787697.1">
        <property type="nucleotide sequence ID" value="XM_056936898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUV2"/>
    <dbReference type="GeneID" id="81627147"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5477153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="20890" checksum="12D365D6E940F6EA" modified="2023-11-08" version="1">MPHAESDTMGQPMVNGEKAHSQFLEHLTSYPVVSDSISLVKSNAYAAKSLQLSDQAYARFAKPVLPYFSTPYSYLAPYLARADAIGEKGLSEIDSRFPIIREDTQKIRGTLYDTAGLPIRVAGDVKQHLFQTYGSEYKKCGGDGVVASGKAVITTSLVLSTESLTYLTTWFQKAKEESKDVINEKANSHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUY3</accession>
    <name>A0A9W9WUY3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit J</fullName>
            <shortName evidence="5">eIF3j</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 30 kDa subunit homolog</fullName>
            <shortName evidence="5">eIF-3 30 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">HCR1</name>
        <name evidence="7" type="ORF">N7539_007348</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit J family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUY3"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.60:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03009">
        <property type="entry name" value="eIF3j"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5477204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="265" mass="29883" checksum="C74732CDD741DADE" modified="2023-11-08" version="1">MAPSKWDEEEDSVSPPPVARRRFDDEEEEEVLDSWDAADDSETEREKAKKAEEALAKAKAAAAANKKTKAQRIEEHRDQRRREAEDSDEEGYEDETEAERRERLRRTEKDADMQHASDLFADIDMNRNRGAPKAVVITDSANPTNSIDLSSMPLFKPTTKDQFARLTDVLIPLLTPQSKKPHYALWAQDFARKLVKELPSADIKKIASALTTASNEKMREERAADKGNKKTKAAKTKVSLNANRDSQIDNTAYGDEDGLGDDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV32</accession>
    <name>A0A9W9WV32_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_007191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787591.1">
        <property type="nucleotide sequence ID" value="XM_056936792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV32"/>
    <dbReference type="GeneID" id="81627041"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5477047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="62" mass="7037" checksum="0EE230906C7639BC" modified="2023-11-08" version="1">MFSRRGVYGEGSVCVVVGSRVGQKWRWRRAHRAMNGAGAGVGRQERVVDRLESMEDWWTAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVM2</accession>
    <name>A0A9W9WVM2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Arsenical-resistance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_007514</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787914.1">
        <property type="nucleotide sequence ID" value="XM_056937115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVM2"/>
    <dbReference type="GeneID" id="81627364"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015104">
        <property type="term" value="F:antimonite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000009">
        <property type="entry name" value="Arsenite transporter, ACR3 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057:SF1">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="ARSENITE EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5477370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="43861" checksum="4D2EC274C1282AA4" modified="2023-11-08" version="1">MATTFSQTGLPAKNDPQMNQTTLNDQPTPDSPTAGDVEKQKTTAPEEEEEEAMAKQSAFKSLGWLDRFLAVWIFLAMAIGIILGNFVENTGPALQKGQFVGVSVPIAIGLLVMMYPILCKVRYESLHQVFQAREIWVQIAFSIFVNWIIAPFLMLALAWAFLPDEPELREGLILVGLARCIAMVLIWTGLAGGDSEYCAILVAINSLLQMVLFAPMAIFFINVISHSSNQVAMSYSTSAKSVAVFLGIPLGAAILTRMTLRKIASPRWYDQVFLKWAGPWSLIGLLFTILVLFASQGRQVVHQIVSVVRVAAPLIVYFIIVFFVTLLVTYKLGFGYKLAATQSFTAASNNFELAIAVAVATFGANSNQALASTVGPLIEVPVLLGLVYVVKFIAKRVGWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1I7</accession>
    <name>A0A9W9X1I7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_006553</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788089.1">
        <property type="nucleotide sequence ID" value="XM_056936154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1I7"/>
    <dbReference type="GeneID" id="81626403"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
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        <property type="match status" value="13"/>
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        <property type="match status" value="2"/>
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        <location>
            <begin position="189"/>
            <end position="346"/>
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            <end position="868"/>
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        <location>
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            <end position="904"/>
        </location>
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        <location>
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            <end position="937"/>
        </location>
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    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1018"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1053"/>
            <end position="1085"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5480659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1180" mass="130845" checksum="1F7A5303402ACE4E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9W9X1U4_9EURO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5480823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="527" mass="59163" checksum="CC0113A470FE1DB1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X295</accession>
    <name>A0A9W9X295_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase III subunit RPC6</fullName>
            <shortName evidence="6">RNA polymerase III subunit C6</shortName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">N7539_006974</name>
    </gene>
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        <name type="scientific">Penicillium diatomitis</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
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            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788510.1">
        <property type="nucleotide sequence ID" value="XM_056936575.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81626824"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpc34-like"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
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    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpc34"/>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR028763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5481080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="350" mass="39051" checksum="D894ADA603FB9D16" modified="2023-11-08" version="1">MASRVTEVAARLYDACVERFDVDHLFYQQDLLGLDVIPKAEIDLLLKCTQALVDQKLFRLHQGANNRLAWKIISRDDAEKLQNLNPDESLVYNVIHSSGRSGVWIRNIISRTNLHKSILDRCVKSLESKNYIKSVHNVKYPTRKMYMLAGLAPSEDITGGAWFTDGVLDANFINSVAGYIEYTVSRRSWYEVPATDRGRNKRLKTASGKAEVKLESEKVYLPYPANYSGYPTVDMITNAVNQSGITPVRLGEESIVQLLQMLCFDRKLVALNNGNNYKSLKNPEVVKASQSRKPAAEEEAGGPILGMGKNGMTEAPCGSCPNIKLCSPGAAISPETCEYFDPWYEKVLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2D9</accession>
    <name>A0A9W9X2D9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788415.1">
        <property type="nucleotide sequence ID" value="XM_056936480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2D9"/>
    <dbReference type="GeneID" id="81626729"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481:SF0">
        <property type="entry name" value="LD23870P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481">
        <property type="entry name" value="RIBONUCLEIC ACID BINDING PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5480985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18541" checksum="DF692DFD8E9AAFEF" modified="2023-11-08" version="1">MNKAFMTNRGTAYIVYYDAADAEAAISHMHEAQLDGVVLNVSIVLPRRNFSLSPPPASNRGAGGRARFGNRNRADSPPRRHGRGRPGDRRDTYRPPSLSRSRSPVRARSYSRSRSPPRRGSRRADSPRSRRRRGSSYSSYGSRSRSRSRSRSRSPVRSRSRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2G5</accession>
    <name>A0A9W9X2G5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_006746</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788282.1">
        <property type="nucleotide sequence ID" value="XM_056936347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2G5"/>
    <dbReference type="GeneID" id="81626596"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021627">
        <property type="entry name" value="Mediator_Med27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11571">
        <property type="entry name" value="Med27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5480852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="326" mass="36702" checksum="0F45BA0CCBD76051" modified="2023-11-08" version="1">METSATMKVEDSMPKTATRVTSSDSVAINWDSELQLVSSLAKLQELERRIHELRQLVPSNDVDSLDAQMNLLFDKSVERFPDSADEASSTLDESTRTKMELVDGFISAWQNSDMKDVWAHVESQINDSDSHVLQPTGMWERDYDVLLDDLLRAEKTKEHQHSLEKEAAERSQAQASAESWKSILEQFEKRNTRGVKASVISQVTPKLLMALLKTGMIFSIQCVQLPDAEGSTEWMVSINAVPKRAPSKIEESIMQHVNSRPRKWDLAFLMDMISSYSDLKQTVCTKCNQLTDTSAQLPILRRVQAIPPAKPEDEGFVFDALHASCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2K9</accession>
    <name>A0A9W9X2K9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_006806</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788342.1">
        <property type="nucleotide sequence ID" value="XM_056936407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2K9"/>
    <dbReference type="GeneID" id="81626656"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="5">
        <location>
            <begin position="32"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5480912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="286" mass="30205" checksum="A594AD533F8CD9B8" modified="2023-11-08" version="1">MTTPSNNDNNNNTSSTPNMAATPARTSTLLTNLSAVTSRIATATSHSPTPTKSVRLVAVSKLKPASDVLALHHSPAAHSHFGENYLQELLEKSRLLPPPPSTGTSSAASSPTNASRLPATVDTAKKATLLDKGRGERKPDAEEVEAKAAASKESGVEEGRLRVYVQVNTSGEENKAGVEPAEAPALAKHIREKCPRLKLQGVMTIGAIARSRATTPETENEDFVCLRETRDRIVSELGLTGSDAELELSMGMSSDFEGAIALGSDQVRVGTTIFGDRPPKSEAKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2P3</accession>
    <name>A0A9W9X2P3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF159 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_006263</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788789.1">
        <property type="nucleotide sequence ID" value="XM_056935865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2P3"/>
    <dbReference type="GeneID" id="81626114"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604:SF0">
        <property type="entry name" value="ABASIC SITE PROCESSING PROTEIN HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="DC12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="76"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="317"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="317"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5482817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="45995" checksum="357238BBD0940D48" modified="2023-11-08" version="1">MCGRYALGVVSLIRLSPPLIYTYDLTNKERQRLAFIQQQLQERGLQVDEAPDDDEVRETYNFAPGNIGVVYRAEATGAKEPSEKDNEARNEPQQTAPASEVQGDTGKNGSASGVHPKYKLQGMKWGLIPFWTKRQPDYGSMMRTINCRDDSLTENRGMWTTMKQRKRCLVICQGFYEWLKKGPGGKEKVPHFVRRKDGDLMCFAGLWDCVQYEGSDQKLYTYTVITTSSNSYLNFLHDRMPVILDYGSDAMRKWLDPSRKTWSSELQSILKPYEGELECFPVSKEVGKVGNNSPDFIIPVDSKENKSNIANFFANSKSKDASPKKHTDIKVEDVKAEQRDAPHGIKRELSLEGLNPDEGNENKKRRSTKIPFLPRHRKAGRGVPPIIRHGKSRADRSPQMDLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X588</accession>
    <name>A0A9W9X588_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_005807</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789281.1">
        <property type="nucleotide sequence ID" value="XM_056935409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X588"/>
    <dbReference type="GeneID" id="81625658"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1020:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.50:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028998">
        <property type="entry name" value="GINS_Psf2_subgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="12">
        <location>
            <begin position="11"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="11">
        <location>
            <begin position="146"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="240"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR028998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5484011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="270" mass="29641" checksum="4A578BF3FFEB5B8B" modified="2023-11-08" version="1">MAFPLPRGIVASEIAFLAEMETVTVVPRQRLEGLELLGGPIEPLVPPRRASLPLWLALLLKRQRRANIIPPSWLHPESLSLILEVESQHQDYKNAFSPPPPLPGQPSVRDQGLEPTARPQYTLDGNRYYAAPPFLPQNTAQTTVSSGEPPALPFHWIEVGNMLLDSASDDLMDPGQIRRLLKDLREVRMAKMRSGVDVLDDAAMGGGGVALTGVGAMELGDERGFLSGVVDGLRKIGASKEQARREQLAEQRANGGYNGTQDEEEDYMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5E2</accession>
    <name>A0A9W9X5E2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_005761</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789235.1">
        <property type="nucleotide sequence ID" value="XM_056935363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5E2"/>
    <dbReference type="GeneID" id="81625612"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF60">
        <property type="entry name" value="RNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_1G02950)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="260"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="344"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5483965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="422" mass="46418" checksum="D704A4C9EEDA3374" modified="2023-11-08" version="1">MPSFGREKGQSSRTRKSDDEYVLFLQGVPAHCRWQELKDLVRQTALHIRQAVVYDDNHGVPTGLGQIIIKNEEEAWRTYHRLSTNGWEGRSLIVTLARTSAPTKPVAGPTRSPSAMMNGYLPGQSTPPPLLSQASMMVPSSPISPSSDHTGAHTWPYPDFMPMSGSGQMCHAHGSCLPIMSDLHQCLPTSPMIPCSMFDLQAWHMLPPMYPLSPVQSHHDNVRRDRDGHYTHGAHGPNQQWVTPPSSSSSPVPQGPNRETEIQITNIDPKTTQADVTHLLQDAGLGAEHGRILLTSRTRDDSPTSTHTYTASIIFNSADEAKNAAHVLNEHPFKDSQVHVQITTPRPCPGPSQHQHQSPKSGNWAIHPDAADIDQSESSVHEKSPDLTCDKVNPTTAREPSQIDFSRPLVIDGSGMRKKCTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5S0</accession>
    <name>A0A9W9X5S0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein ABC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_004941</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789737.1">
        <property type="nucleotide sequence ID" value="XM_056934543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5S0"/>
    <dbReference type="GeneID" id="81624792"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="393"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5484953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="747" mass="82833" checksum="938AFE98FE80CB93" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5Y9</accession>
    <name>A0A9W9X5Y9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pre-mRNA-splicing factor cwc21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_004928</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789724.1">
        <property type="nucleotide sequence ID" value="XM_056934530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5Y9"/>
    <dbReference type="GeneID" id="81624779"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="8">
        <location>
            <begin position="61"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5484940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="219" mass="24515" checksum="8348C8D014A25E6B" modified="2023-11-08" version="1">MSSNVGLSTPRGSGTSGYVQRNGAFLKPRATGVGAPYPPVSGANGPPDRAFKQRLPDKQILGHDRRRAIEVTVMEERERLEEANERLEEAQAESKSKAKAKKQSQPRSEDTKDGGEEEESGSGVTERILSEEEIDERCDALRQRLLKELEEDDAENAAGGAARGKKVAPLDRRQFKTYQVHELAEAKIEESERLRKALGLREDRETGEITSKRFERRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6J8</accession>
    <name>A0A9W9X6J8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_005273</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790069.1">
        <property type="nucleotide sequence ID" value="XM_056934875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6J8"/>
    <dbReference type="GeneID" id="81625124"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF4">
        <property type="entry name" value="SPORULATION PROTEIN RMD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="645"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="434"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5485285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="734" mass="81479" checksum="BADE9AC77458068F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6R9</accession>
    <name>A0A9W9X6R9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="3">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_005144</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789940.1">
        <property type="nucleotide sequence ID" value="XM_056934746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6R9"/>
    <dbReference type="GeneID" id="81624995"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="12">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5485156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="313" mass="34698" checksum="301FBFE674914742" modified="2023-11-08" version="1">MAAADVRFRLNTGAEIPALGLGTWQSAPGEVARAVYHAIKVGYRHIDGAMCYGNENEVGQGIKQAIDEGIVTREDLFVTTKLWCTYHTRVQEGLDESLKNLGLDYVDLYLMHWPLAMNPNGNHPMFPKLEDGSRDVLHDHSHVTTWKSMEKLVPSSKVRAIGVSNYSVKYLEELLPQASVVPAANQIENHPSLPQQDIVDFCKDKGIHITAYSPLGSTGNVLFKAKPIVEVSEKRGVSPASVLLSWHIARGSSVLAKSVNPDRIEANRKDLIRLDDDDMATIQKYIDELAATNSFQRLVFPAFGKTFGFPDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X784</accession>
    <name>A0A9W9X784_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790356.1">
        <property type="nucleotide sequence ID" value="XM_056935162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X784"/>
    <dbReference type="GeneID" id="81625411"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="527" mass="58398" checksum="AEDE7FB0E7B1088A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XBR2</accession>
    <name>A0A9W9XBR2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pre-mRNA polyadenylation factor fip1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_003359</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790502.1">
        <property type="nucleotide sequence ID" value="XM_056932961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XBR2"/>
    <dbReference type="GeneID" id="81623210"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007854">
        <property type="entry name" value="Fip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051187">
        <property type="entry name" value="Pre-mRNA_3'-end_processing_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484">
        <property type="entry name" value="FIP1-LIKE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484:SF0">
        <property type="entry name" value="PRE-MRNA 3'-END-PROCESSING FACTOR FIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA polyadenylation factor Fip1" evidence="6">
        <location>
            <begin position="161"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5488469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="339" mass="36305" checksum="31D9A51FB85821D1" modified="2023-11-08" version="1">MMDDEEDDFYDPADSVPAGQAASSAYNEAGQQQTDGFEDDEEEVEVEDDDDDFNIITEAPADAPPPEISHPRHTSLRQEPQRAPSADPSIVPKSATPSGTPHLEVATPVPATAGTTAPSTKQSMPLRPGSSYPAVHTSTIDVNGNPVHPSTGKTIMATDMDADFPADDKPWRRPGTDMTDFFNYGFDEFTWVSYCLKQQEVRKEVGDQKKQMEDMTSFLGMGMPPMPGAPPVPVVPGPAAPPMAGMPGMPDMNPEMMQGMLASMMSQGLDPSSMDPMAFMQHAQSMMGGQSGPSQQGQGGFGNQGQGQNYGQGVQGQMGYGGYDQRGNYGGGRGRGRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XBY9</accession>
    <name>A0A9W9XBY9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_003354</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790497.1">
        <property type="nucleotide sequence ID" value="XM_056932956.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81623205"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="781"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5488464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1330" mass="145514" checksum="684E88D2104221E1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XC66</accession>
    <name>A0A9W9XC66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_003457</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790600.1">
        <property type="nucleotide sequence ID" value="XM_056933059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XC66"/>
    <dbReference type="GeneID" id="81623308"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="5">
        <location>
            <begin position="19"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5488567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="485" mass="53627" checksum="704294C3B14FFC80" modified="2023-11-08" version="1">MTESFPAAVAGPTSKERKYDRQLRLWAATGQQALEDSRVLLVNSDGPLGGDNTGVSGVVGVEALKNLVLPGIGGFTIVDPATVTEADLGVNFFLQEESLGKSRADETCRLLRELNPDVQGYSYSKPVTDLLNDPFFLPRHKLVIITGPTRQSTLTSLTQAAQRLGIPVLYVHSVGFYSTFSLQLDADFPIVETHPDPESSQDLRLLTPWPELSAAAASLGDLNALDDHRHGHIPYIMILLHLVEQWKQGHGGNPPGNYREKTEFREFVRSHARTSNAEGGEENFDEAVAAVLKTVTPFSLRSSTREIFEMDECQNLTRQSSDFWVIASAIRGFYQEHHVLPLPGSLPDMKAQSADYVALQNIYKAKARCDIDDVTARVRQLESRLGRSKSPILDREIEVFCKNAAHIKVVHGRPVARLTHATDPVTLKAIRNQLNTPDSLIPIFLAAQILDAVVDEIKVGIRKRPNFQSTTTVFGLIIQSVSWHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCJ8</accession>
    <name>A0A9W9XCJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Meiotically protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_003561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790704.1">
        <property type="nucleotide sequence ID" value="XM_056933163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCJ8"/>
    <dbReference type="GeneID" id="81623412"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF0">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028846">
        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040934010" evidence="2">
        <location>
            <begin position="19"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5488671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="535" mass="59283" checksum="FAB5B247FD9AD3B2" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCN3</accession>
    <name>A0A9W9XCN3_9EURO</name>
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        <recommendedName>
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        </recommendedName>
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        <name evidence="2" type="ORF">N7539_003373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
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            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790516.1">
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    </dbReference>
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            <begin position="12"/>
            <end position="35"/>
        </location>
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        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="28102" checksum="639F621FA9DBD1D4" modified="2023-11-08" version="1">MGAAGGAVLRFFGLAIRVLQFLASAVILGIFSYYLAMMSRHGLAIPTWTKAVEGLSGAAALYSLLGALFVCCLGGIAFFAFTAIVLDICFVGAMIAIAVMTRHGTQSCSGYVQTPLGDGDASSGADTRAGTSFKNSCNLEKAAFAVSIIGIFFFLISIIFQVLLARHHKREKRFGPSPANNYTSGTSRKWWSRKKTYPEASGGVDTLPAHPTPADIELGAEKQAPQKKRFGLFGKKKEPAPFADTAPNNARTGYGYGGSAYTGNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9W9XDF5_9EURO</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_004147</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791290.1">
        <property type="nucleotide sequence ID" value="XM_056933749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDF5"/>
    <dbReference type="GeneID" id="81623998"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052602">
        <property type="entry name" value="Growth_transcription_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022092">
        <property type="entry name" value="TMF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022091">
        <property type="entry name" value="TMF_TATA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515:SF1">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR TMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12329">
        <property type="entry name" value="TMF_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12325">
        <property type="entry name" value="TMF_TATA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA element modulatory factor 1 TATA binding" evidence="6">
        <location>
            <begin position="767"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="35"/>
            <end position="232"/>
        </location>
    </feature>
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            <end position="274"/>
        </location>
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            <end position="467"/>
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            <end position="51"/>
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        </location>
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        </location>
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        <location>
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        </location>
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        </location>
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            <begin position="696"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5489257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="882" mass="97926" checksum="5F174298A6243560" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDF7</accession>
    <name>A0A9W9XDF7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein-sorting-associated protein 24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF03357">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
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        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27562" checksum="283042A497527F0A" modified="2023-11-08" version="1">MESLKAVFFGPDPQAQVLDLTSGVTGHSQMRKCNALIRQNTRQLDRDLNQLKTLDSKTRQYIINASRRAQRNPSQAKQALNETKTFARELVRIRKQTNRLSTSRAQLQSVGMQVNEAFQVRKIQGSLQKSTAIMKDVNTLVRMPELTSTMHQLSTELVKAGIIEEYVDEALPDDSLMEDELDEAEEEVDKILQEVLQGKLSQAPANPVTQPVEEIPVAAEPEEEFEDQEATLSQMRDRLEALKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDJ6</accession>
    <name>A0A9W9XDJ6_9EURO</name>
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            <fullName evidence="2">histidine kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_004304</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
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        </lineage>
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    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791447.1">
        <property type="nucleotide sequence ID" value="XM_056933906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDJ6"/>
    <dbReference type="GeneID" id="81624155"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000023">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000083">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative (AFU_orthologue AFUA_4G00660)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000201">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative (AFU_orthologue AFUA_4G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="622"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1108"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="288"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1043"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1047"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5489414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1228" mass="135392" checksum="46F91B800DE4A01F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDX9</accession>
    <name>A0A9W9XDX9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791484.1">
        <property type="nucleotide sequence ID" value="XM_056933943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDX9"/>
    <dbReference type="GeneID" id="81624192"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037504">
        <property type="entry name" value="PSI_induc_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018:SF1">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="454" mass="49307" checksum="ADCF142D9912C65C" modified="2023-11-08" version="1">MMSPPGLARFVIRNVANDLESVPATFSSWDKCMTKAYCKWPVIAGIIIGAVILISVIGCIVNCLCCGYQCCKCCCGCCCPSGRRREKQPKHYNEPAPYQPPPPQNPHTAYQPPSAPPIYRGASQTATFDSGSKSPAVNEDALPAMPTWAAAVEKHVEDKSHHDEMELEPLNPSHNIPNRSRGASPLHTRHSSSDVLPDRSRSNAGYAGIPSADPYARPSPGSTTALSPLQDPYGCRSPGNGMPGTPRGADSYARTSPGPQPTIDLYSRQSPGPPAAYGPAQDPYARRSSGVTSPLNGNSSSYLYNNPTQQDRRQQGYNRQSYGQDSYNHQYYNNRHQQPYDDYNQNTTYQGAGSSTPVSTYPTQSSTHPTASRFAQSPDPAHPDPVMGDFHRQPSFGSSQYPPTYTSHAASPPPPFQSTAPSEYGFAVTEPSRERPPSLLQSGRKPVPNTYRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE06</accession>
    <name>A0A9W9XE06_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone acetyltransferase ESA1</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Histone acetyltransferase esa1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 22">protein 2-hydroxyisobutyryltransferase ESA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15 23">protein acetyltransferase ESA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 24">protein crotonyltransferase ESA1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">N7539_004386</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:53909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:131780"/>
            <dbReference type="ChEBI" id="CHEBI:144968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:24181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791529.1">
        <property type="nucleotide sequence ID" value="XM_056933988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XE06"/>
    <dbReference type="GeneID" id="81624237"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000022">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF218">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE ESA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="27">
        <location>
            <begin position="217"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="88"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="25">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00074445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00075313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00076782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00077673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KAJ5489496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="481" mass="55211" checksum="D07649BDBA753D4A" modified="2023-11-08" version="1">MGPREPGEATGTPDPVEKGLATINTITLGVKAMVQKDGELRKAEILSIRERKGGLSFYVHYVDFNKRLDEWVPAARIDLTQEVEWPRPEKAEKKKAAVTKAPSKNAQKQHRADSREVSSTPDAFGSKNQNVAKAPRPSTAGGKENRDTPGADVSMVGSEGVSVAGTPKVLDSEDLEMPDAPLKEEVKTASGEVITREEEIERLRTGGSMTQNPTEVHRVRNLTKLQMGKYDIEPWYFSPYPDSFSDVDLVYIDEFCLSYFDNYRAFERHRSKCTMVHPPGNEIYRDDNISFFEVDGRRQRTWCRNLCLLSKLFLDHKTLYYDVDPFLFYCMCTRDETGCHLYQRAGYGRLLIAMSYELSKREGKLGSPEKPLSDLGLLSYRRYWRETLVELLAEPNREAMSENELALLTSMTEKDIHETLLVNNMLRYHKGNWLIVLTDQVLEEHNRRMEKEKVKGSRRIDPVRLQWKPPVFTASSRTWNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE28</accession>
    <name>A0A9W9XE28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_004431</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791574.1">
        <property type="nucleotide sequence ID" value="XM_056934033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XE28"/>
    <dbReference type="GeneID" id="81624282"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="37"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5489541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="377" mass="41545" checksum="07424F22CE08FE78" modified="2023-11-08" version="1" fragment="single">MGWVHNASPEVEALSQYREILGVCLSLTLLMVITVCLRLWLRAQSGRLGAADYVMVFSMVSATPTPLELALICQVTSGALHNFRYSALSIAPCVSPVKSRYGLGLPLKLRPALDKAVYTKINYAGRPFYQLGIAGFKASLCLSYLRLISGTSMKLYRILIWTVITLSTLGHLAGALVLILNCTPVRSAWDITVHGHCLPVGPTFYGLAIFTIVCDVVMVFLPIPLLLRLKIKPAQKAGVVCLFLLGLFTTICSILRLSQIHRVAWGDGNSTMLVLWGTIEFNIGNIVTCIPYLTPLLRGFVRDFRSTSNKKYYNSHGRTYAMETWSKDQRSQLQSSASGPAAPRRSPSEELILSSKEPVHGGIEMTVEYSVSLEKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEX1</accession>
    <name>A0A9W9XEX1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LSM2-LSM8 complex subunit LSM8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM8</name>
        <name evidence="12" type="ORF">N7539_002567</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEX1"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000027">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5491000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="100" mass="11131" checksum="391DD667CA642AF1" modified="2023-11-08" version="1">MSLPLMSLINKKVLILTVDGRTLLGTLLSTDQLTNIVLTNTVERIIRTPDDDEPSAQVEHGLYLIRGDNVVICGEVDEKIDSDIDWTKVKGQVIRDTKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF33</accession>
    <name>A0A9W9XF33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_002518</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792080.1">
        <property type="nucleotide sequence ID" value="XM_056932121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF33"/>
    <dbReference type="GeneID" id="81622370"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="41"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="518"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1196"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="520"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1206"/>
            <end position="1219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5490951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1219" mass="134824" checksum="041AD0EB773A91EF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF91</accession>
    <name>A0A9W9XF91_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002747</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792309.1">
        <property type="nucleotide sequence ID" value="XM_056932350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF91"/>
    <dbReference type="GeneID" id="81622599"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="11"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5491180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="407" mass="46317" checksum="5E54897A042D1D43" modified="2023-11-08" version="1">MSQDSWRPRKRVAIVGGGPGAISTGIAFLKRGFDVRIFERQSSCKAIGGAVLLSTPVLAILRNYGISAEHFGSFTVTYFKNEVGMARVELPFNPEIERKMGIKGWHYGVLRSSIFKKMLELVPEHVIFPGHEFTHYVEKENEVELHFQNGQHVTADIVVGADGIRSQVSRQAFGDPQLFHCGIRLWLAWCDYIPGIPPNTGFISHDRLNQASFFPMTHDGKPGFEWWVVEPSYEGKPIPKDVKAHVAGILKNWAEPMPRFLEATDFDTQVYRWEIYNRPSLKKWSSGRIVCVGDAVHPVSPYAAYGMGMAIEDGYFLARALDGVDLRDKHAVSAGFELYEQERVDYVNHNMEFARHLGRLFHSVPRPLANVRDWIFDNTPLLSYFMKNGYLKNSEEETLRLKELHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFH0</accession>
    <name>A0A9W9XFH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792424.1">
        <property type="nucleotide sequence ID" value="XM_056932465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFH0"/>
    <dbReference type="GeneID" id="81622714"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="386" mass="44418" checksum="55A4DD66AC38885A" modified="2023-11-08" version="1">MNPVRQDNTHLSHGMGLEWELAYQRVLAEHPEPWKIYTPVHQPAWERAYRQAEAVSTDQAQSSSTHSRHLHNQTQATHSTQIMRQTHADDHIQVTGQYPRMWYPQQATYTPGPEEARGSLQPTSPPFCMPSPEHIYVRSAKLGDFKDVLRIINWYSTRYALNWTSNFLTIADYFQFLQVCLIQNLPFLILVKVDASPSSSATTTPIPGNETICGLAYIDIFEGDSLLGDLRVYVCPKMNGRGYGNRLVDCILSIMDWNHQPQFLTECQLEDLMEKSLPRLKQLTCAISYPAQREEEHAYIWHWLMRRFAFKYEGESKQDRPKHGHAENFFCLSRGINKKQPTTVDAYPDAYMQGQITAGQDNSSQAQHLSRAEITWREKKQTGQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFN5</accession>
    <name>A0A9W9XFN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792202.1">
        <property type="nucleotide sequence ID" value="XM_056932243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFN5"/>
    <dbReference type="GeneID" id="81622492"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="162" mass="17464" checksum="672E65D034D6E966" modified="2023-11-08" version="1">MLLIPVTAVTAAIAAQSRTSDQSSMSVDAMQCRRLLAAASVLPSVLFDPLGVNDQAHWHDHQPVLSTNWGYVCPLDQRSAAEMKVSRRPSNGHCLHITNTVSISQASAVETRGALPASMPRESWSPRSGSANAEVKACSSHYPLLSSLTRRGRVHEPLQDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG15</accession>
    <name>A0A9W9XG15_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_002509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792071.1">
        <property type="nucleotide sequence ID" value="XM_056932112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG15"/>
    <dbReference type="GeneID" id="81622361"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF274">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5490942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="257" mass="27028" checksum="11030586D4BC61B3" modified="2023-11-08" version="1">MARFLITGSSDGIGLATAKVLAGKGHSVVLHARNSARAESTRQAVPQAEAVLVADLRSVTETKQLAQEANKLGNGTFDAIIHNAGIGYGSTSSREITADKISAVFAVNTLAPYILTCLMKKPTSRLLYMSSDSHYGGDESLRNATQSHSYSDSKLHDVMLANAFARRWGGDIQVVSMHPGWVRTKMGGSMASSGLEETGDAIADWAMGVGNLANLPSGSFLTIAGARSTHPGAGKVEKQEELLKLCREVSGVAIPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG55</accession>
    <name>A0A9W9XG55_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792732.1">
        <property type="nucleotide sequence ID" value="XM_056932773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG55"/>
    <dbReference type="GeneID" id="81623022"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="120" mass="12872" checksum="CF67E93B59F7DE13" modified="2023-11-08" version="1">MRSYVGGKNGAISGRRPTTLSGNNRYSRVQLRIPSAAILLNCTIALPSASILLSKPYQLGSQPVSQPTSLPVHAKDLRPTKSGLQVIQCDLGGNEESLQYKTYSRAFAGRNSSARVVGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGI9</accession>
    <name>A0A9W9XGI9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002945</name>
    </gene>
    <organism evidence="2 3">
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            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5492675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="624" mass="69321" checksum="FEF7F7F03464CCC1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHJ6</accession>
    <name>A0A9W9XHJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_001898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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            <authorList>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493152.1"/>
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            <begin position="315"/>
            <end position="441"/>
        </location>
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            <begin position="443"/>
            <end position="547"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="167"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF23074"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF23076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5493152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="560" mass="64283" checksum="E68F7784DDA487DB" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9W9XHZ1_9EURO</name>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
            <begin position="22"/>
            <end position="42"/>
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        <location>
            <begin position="55"/>
            <end position="124"/>
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        <location>
            <begin position="217"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="326" mass="36294" checksum="CFF9321E910CF964" modified="2023-11-08" version="1">MQTVTMQFSPIKEGRRILGDRDSNACLSPAHHSKSALGGFSTPVKRNLFTNVSPKKLLPSPIFAGQKRTREQLDEEDVHAPRERRVEDSPSTLKNESQRPVVDCKETEHPTPNSTSRPEHEEPQEDHIITLHSASHKRHAQTSPIPENPDARRIFIQTKAALLRKKLQSAMRNNADKHIDRRVSDLEEHRRKVPRIPMSALSFSSPAVMVRHTYTPSQLKTPRIGSDPQAHLDSTPCQQTPDLPQPPSSIIHDAVDHNQGHRTPPRGLGSPMQLSSPPATVVRHTRTREKADGGDSEKETTSHDPCSPSQRGDAVDGLLKLMSTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIA6</accession>
    <name>A0A9W9XIA6_9EURO</name>
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        </recommendedName>
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    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793269.1">
        <property type="nucleotide sequence ID" value="XM_056931238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIA6"/>
    <dbReference type="GeneID" id="81621487"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S15/NS1, RNA-binding"/>
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        <property type="entry name" value="Ribosomal_uS15"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
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    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_S15"/>
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    <proteinExistence type="inferred from homology"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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        <location>
            <begin position="23"/>
            <end position="38"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5492889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33617" checksum="21D68F818560C5BA" modified="2023-11-08" version="1">MQPQFRAFTATLLGQGHLTARTSQATTHASIRTASTKAKASPQKRSDFFKLAQARQRKAANLSRQKVLQAEREASLGDPVKSKPTSFIQEIEAIQAGSQNSTLSSGLNYYLQAEELNGALQFSKDLVEPLQNPDRDTADPQLEKEAAELHQKEHQNAQDAIQRIVNLSNGNTKDRLRLNVQKCIYQFGRHNTDQHLPPKPSSALQGSMPGQPQKVPRIGVDTGSPEVQAAILTVKIMNLYRHLQTANKDKHNKRNLQILVHKRQKLLRYIREKERGGPRWQNLMETLGLSDAAWKGEIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIL3</accession>
    <name>A0A9W9XIL3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase I subunit RPA34.5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793419.1">
        <property type="nucleotide sequence ID" value="XM_056931388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIL3"/>
    <dbReference type="GeneID" id="81621637"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013240">
        <property type="entry name" value="DNA-dir_RNA_pol1_su_RPA34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053263">
        <property type="entry name" value="Euk_RPA34_RNAP_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28155">
        <property type="entry name" value="ACR243WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28155:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34.5-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08208">
        <property type="entry name" value="RNA_polI_A34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="36732" checksum="763981F9D232C5BA" modified="2023-11-08" version="1">MAVASSTSSDSSSSQSTSPEPGHKQTKAVKAINKKKDVIEADVSESSDSSDSSDSDSSSEAGSDSESGSGSSSEMDTREDTTEDSSSKKVHIPGPNQPYKPPSGFRSAKKQVPPSSSASAALSNLRGKQVYHITAPSFLPLSKVKEITMSKVLKGEPLITLDGKQYGIPADSIEENDPEGKSLLTFDETTQTYCHRADHIQSLHVQELIGLPIEAASSNAAAIETLRNYVKPPRPQPKGMKMRFRPVGSLPSAPETLGASSESESEESRPQISSDKKEKERKRKHHHTDADASQAVAEPRKKSRKHAHDRAEEAEPIQKKSKKSSKDREEKKRKKSEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XJ15</accession>
    <name>A0A9W9XJ15_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosome assembly protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002191</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793825.1">
        <property type="nucleotide sequence ID" value="XM_056931794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XJ15"/>
    <dbReference type="GeneID" id="81622043"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="7">
        <location>
            <begin position="36"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="141"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="227"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="275"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="398"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="470"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="512"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5493445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="545" mass="59937" checksum="26C24DB7E9622E72" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMN0</accession>
    <name>A0A9W9XMN0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit tim17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_000895</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794792.1">
        <property type="nucleotide sequence ID" value="XM_056930499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMN0"/>
    <dbReference type="GeneID" id="81620748"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5495779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="151" mass="15943" checksum="DF33A250152C5976" modified="2023-11-08" version="1">MDHSRDPCPWVALSDFGGAFCMGAIGGAVWHGVKGFRNSPYGERRIGALTAIKARAPVLGGNFGVWGGMFSTFDCAIKGIRKTEDPWNSIIAGFFTGGALAVRGGVKAARNSAIMCAVFLGVIEGVGIGFQRMMADNTKLELLSSFLLLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMR0</accession>
    <name>A0A9W9XMR0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794839.1">
        <property type="nucleotide sequence ID" value="XM_056930546.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81620795"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="191"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="401" mass="44059" checksum="96A7A8B6D82827E1" modified="2023-11-08" version="1">MADQYDSQYALASSSPSVGPPRIKSIFLHPVKSCGPVEVDRARVTKIGLLYDRCMAIATRTVGSKDPAAAQWRFISQRTKPCMSQIRTELWLPHRSSDPSDPLVQSGGCLVLSFENPDRASWTDQLETVIYARDLAARPRISFIVPLNVPNGELTAFGIHSRQAKGVDLGQIPSIAAALPSLKKFLGLSANQSLTIFKCTPESLTRTEKNLAPLEHIGSPAVHGYTDQQPININSLSSVHEVSSHLPKENQPLDALRFRANIWITKSIAYEEETWKRVRVKPRVATKTRPSDATLVLSIVCRTSRCTMPNVNLSTGAFDADLPAEGKKKGKPQPSTTLLQHRTVETGNPSALGYLGMHCVPEDKSLNAAEESDWGPYIEVGDELEVLETGEHLYGFTGMDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMU3</accession>
    <name>A0A9W9XMU3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted thaumatin-like protein calA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794930.1">
        <property type="nucleotide sequence ID" value="XM_056930637.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81620886"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SECRETED THAUMATIN-LIKE PROTEIN CALA"/>
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        <property type="entry name" value="Bys1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040905677" evidence="2">
        <location>
            <begin position="20"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="197" mass="20494" checksum="6DEF1DB77EBFE679" modified="2023-11-08" version="1">MGFLKKITLFGLIASLATALPQHTRPTATATLVPVTSSTSVTPSATPTTTGPSSSSGSGINIVNNLNQTVYLWSISNTGGDMQTLPASGGTYTEKWRINSDGGGISIKMATTTSLSSVLQFEYTKGDDTLWWDLSSINLAPDSLFISSGFQVTTDDSSCSSATCHAGDVGCKDAYQKPDDVDTRSCSSAAAFKLVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMZ7</accession>
    <name>A0A9W9XMZ7_9EURO</name>
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        <recommendedName>
            <fullName evidence="10">DUF726-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_001075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794972.1">
        <property type="nucleotide sequence ID" value="XM_056930679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMZ7"/>
    <dbReference type="GeneID" id="81620928"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF22">
        <property type="entry name" value="DUF726 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="546"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="546"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="586"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="603"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5495959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="69860" checksum="293AF60952F04D84" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN20</accession>
    <name>A0A9W9XN20_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795050.1">
        <property type="nucleotide sequence ID" value="XM_056930757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN20"/>
    <dbReference type="GeneID" id="81621006"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5496037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="411" mass="45749" checksum="7D94F15AA98EC673" modified="2023-11-08" version="1">MTLSFERTRSPITGWFRSCWDCFEREMQICHSQPHLVPPMKLVVYDDLPSPGLPQQSRNSLSSWFEEGRHMASRVSRRASLSWKRPPPTPLKISDPSDFRRVQSFQLDPTPAQSPLFEPLQLSIHRLSNRLSDLPSFESFCMGGDDHDETPAPSTMTLQARRQSIDARFSISRKPVGSVARRMSVNSERLIRYPPPAHFAGSLLPHFSSDTAAGPAGRLLDRSIHGTFEKTQDDVSRTASKSTPNNQQYFAAESLSSHSTRTFPSRLSSLRRPSTTETQMCLTSEPLPEKIHEWDFDEKSSTAGKGFHVEADVCGGERFRSLSGTTLGSAVTSPTGRAFEHRANDSFSSASTNGVTPRTLPPLLHLSSEKALEARLVKQRSLDSQHRQCPPSPYYADGVSQYRGSAIGIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN34</accession>
    <name>A0A9W9XN34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794643.1">
        <property type="nucleotide sequence ID" value="XM_056930350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN34"/>
    <dbReference type="GeneID" id="81620599"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="190" mass="20697" checksum="DA2210271F3409F2" modified="2023-11-08" version="1">MAAVRLRNAFRYPDDLDDDQDHLDEQQQEQLIEQLQRQNDTRNAQYHLIFTTIPLLATLPFLFTLFSSSSMALLSILSILSLLTSAYTMRLAPLRPDHKGKRAVTASTQRRDRIHAALVPGNALLVLVLGGSGWAMRGAGTGAGAGAGMGIGMLFFIPGVLLGVVLIAQRTMLSVDISTLKQLQYGYKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XNX1</accession>
    <name>A0A9W9XNX1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_000810</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794707.1">
        <property type="nucleotide sequence ID" value="XM_056930414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XNX1"/>
    <dbReference type="GeneID" id="81620663"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="363"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5495694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="478" mass="51915" checksum="671172F0AD9B9E5E" modified="2023-11-08" version="1">MTAGRLPVRVLAVLDSSASHDFIQPIKRINESQDVSAFLTSKAYSDIMTFVLQLNRAMFPSKLEDGSVQSWPLGSEAVQFSAPIRQLQVLLSKLEDLVQEVPPDTGPRRFGNVSFRKWHDTLASRASALLRECLPADLLDRPSSSPSGVTAEAELTAYFMGSWGSSQRLDYGTGHELSFLAFLGSIWKLNGFPQSEFGVEERALVLGVIEPYLELVRLLIKTYTLEPAGSHGVWGLDDHSFLPYIFGSAQLSPAIDATDLTPEEGSAAGAPSPSHVVKPALVERERRLNLYFAAVGFIYDVKKGPFWEHSPMLYDISGIRAGWGKINKGMLKMYNAEVLSKFPVVQHFPFGSLFSFDRDPSAVAPPTTVHTTSGPQGRPVVPDAGPPTTTPRPGPDAGPKYSWANAESTTRGEMPMSPTAAPWAATRSTEVPSTLPVLPDTSRLPPGPMAPTRAPWANTQRPPPPTGGEGRTKAPWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XPD1</accession>
    <name>A0A9W9XPD1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conidiation-specific protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795158.1">
        <property type="nucleotide sequence ID" value="XM_056930865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XPD1"/>
    <dbReference type="GeneID" id="81621114"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019626">
        <property type="entry name" value="Stress-induced_KGG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052590">
        <property type="entry name" value="Stress/Virulence-Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36569">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36569:SF5">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 10 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10685">
        <property type="entry name" value="KGG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5496145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="82" mass="8445" checksum="FB73A4C9FE95592A" modified="2023-11-08" version="1">MTDNTNPGNFANRSKEEVREIASKGGQSSHQGGFASMDADKQRDIASKGGQASSGSFKPGDPRAKEAGQKGGQASGNTESDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJK7</accession>
    <name>A0A9X0BJK7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469342.1"/>
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        <property type="nucleotide sequence ID" value="XM_056938555.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
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            <begin position="26"/>
            <end position="232"/>
        </location>
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        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5469342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="232" mass="25396" checksum="329798D3D1535C84" modified="2023-11-08" version="1">MRSTQFFQCWMILASLIFPSQVTLAKETEDNCSVFDWNHKPATSNSQSPRPVSAAKYCPARSDENSKGQNCTLTGNGTMNFLFSDNTTEPEYHPWLADLIERTLSTANVDMPAPHFNRSVNATIEQTKSLQPGQAGFIAFEAAMFCYEGALQKCTGNIKDGSRARICAPLWSKRGDHVVVTGNYSVVTIDKNQVENYPDPYTSTSGGIWSSKIRGDVLAIGLAVSLLAVLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="4">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
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    </protein>
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        <name evidence="5" type="ORF">N7539_009156</name>
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    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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        </citation>
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        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
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        <location>
            <begin position="596"/>
            <end position="712"/>
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        <location>
            <begin position="121"/>
            <end position="248"/>
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            <begin position="60"/>
            <end position="74"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
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            <end position="388"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="655"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5469538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="712" mass="78444" checksum="07BA46C5E762CAC0" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJQ7</accession>
    <name>A0A9X0BJQ7_9EURO</name>
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        <recommendedName>
            <fullName evidence="2">Phosphoinositide phospholipase C</fullName>
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        </recommendedName>
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        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
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        </lineage>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
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    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="2"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
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    </dbReference>
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        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF82">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="4">
        <location>
            <begin position="351"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5469583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="628" mass="69975" checksum="215ACEA7AC323F80" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJS7</accession>
    <name>A0A9X0BJS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_009155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469537.1"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
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    </dbReference>
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        <property type="entry name" value="dsDNA_bind"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Double-stranded DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5469537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="135" mass="15408" checksum="AA2CE50C87DC9790" modified="2023-11-08" version="1">MADAELEEIRRARLAQLQQQSASRGGPSQEGGQEDQRRQAESERRSAIMSQILDPAAADRLGRIRLVKESRAVDIENRLMMLAQTGQIRQKVTEDQLKELLNAVAENQRKEEEEQKIVITRRKGGWDDDDDLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9X0BLP9_9EURO</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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            </authorList>
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            <strain evidence="2">IBT 30728</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471981.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="XP_056786527.1">
        <property type="nucleotide sequence ID" value="XM_056938145.1"/>
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    <dbReference type="GeneID" id="81628395"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5471981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="158" mass="18490" checksum="CA2F0C0E81A63A45" modified="2023-11-08" version="1">MDAPASVARGDRPCKRRRDDSEANDSQVTNEQQTRDKTLCALYRIRAVPRGMKLSLIEEMKRIIDENPRLASTTIEFLDLYLFLWESYVIDSAHKIRLEEEQQRLQAENAWLIHANNRLYQACTDRELVLWDRQEAFDSVQEAVVKVLKSLRVPSITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BLR5</accession>
    <name>A0A9X0BLR5_9EURO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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    <reference evidence="3" key="1">
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            <strain evidence="3">IBT 30728</strain>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
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        <location>
            <begin position="229"/>
            <end position="248"/>
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            <begin position="89"/>
            <end position="123"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5471980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="248" mass="26450" checksum="96B511C78340F9CF" modified="2023-11-08" version="1">MAKASSSRKPTIPAPPVSIKSGSISSNAASRVTRSAPTGAASRGPSSSGVAKLQKLANASRGKGSSTDEFYQKCIELLAKADETSRRQQTDMEQERLEASQNLQRLRDDASHMKSQINRLMAQEKKTLDEKSELGKQLLQMKQALDAASTTNQHQVACNELYPVIQQAQSSVLATASEVGRMLEIFQNKQNGLYLPDSTLYQDAWPSSAAPLSGSGSSSLPSHAVLPAHPSLGTSNTPSQFGHCGLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BM69</accession>
    <name>A0A9X0BM69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786558.1">
        <property type="nucleotide sequence ID" value="XM_056938176.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81628426"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5472012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="133" mass="14277" checksum="8517E6821F943452" modified="2023-11-08" version="1">MAEETISGDNCFPARNTQQPYCENADEQDISGSAPVAQGLSPPSSCQVPQYNQQGVTPNGEYFLDPTFLNFPPAPSYQTSTTQPASSLPHPSQVNIKVIEQSIIRGAAEEIYVLAFYMADISGQFGVGDQGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BMX0</accession>
    <name>A0A9X0BMX0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_008157</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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        </lineage>
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    <reference evidence="5" key="1">
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            <authorList>
                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786849.1">
        <property type="nucleotide sequence ID" value="XM_056937757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BMX0"/>
    <dbReference type="GeneID" id="81628007"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.20:FF:000006">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
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        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="96"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5475091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="282" mass="30936" checksum="3068CE23D95930F5" modified="2023-11-08" version="1">MGLRAPSLARRLSRTSTPRSNTALVTRRSLTFSSGRDALSFNQLRTAEAVAKHARNLTAKPVYTPSGPHTRRTVSTTTKASTEDPSTLAGAPDTTNHYTIFPQTLPAGPPPHSPFEISVADLRREFLQLQGAVHPDKYPSGTDKQRAEALSSRINEAYRTLSDPLQRAQYLLREWHGIDVTAEDGSAKHALDAGTLMEVMEVQETIEEVGASADAEVQIEALKDENEERIAGCVKALAAAFDRGDVEGARAECVKLRFWYSVGEGLREWEPGNTEIRLMHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BN68</accession>
    <name>A0A9X0BN68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_008442</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787134.1">
        <property type="nucleotide sequence ID" value="XM_056938042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BN68"/>
    <dbReference type="GeneID" id="81628292"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055497">
        <property type="entry name" value="DUF7069"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23239">
        <property type="entry name" value="DUF7069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="387"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7069" evidence="4">
        <location>
            <begin position="586"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="3">
        <location>
            <begin position="676"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="894"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="930"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="960"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1026"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1059"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1092"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1125"/>
            <end position="1157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5475376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1174" mass="130798" checksum="D647F9520524D672" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNB1</accession>
    <name>A0A9X0BNB1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786775.1">
        <property type="nucleotide sequence ID" value="XM_056937683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNB1"/>
    <dbReference type="GeneID" id="81627933"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5475017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23688" checksum="0ADA80F29A787D50" modified="2023-11-08" version="1">MRFPLPYGIGEDPHSSNSDENVLCEAGTHAWIEQNCATVPIPRLCGLGLSNGRTFTLRDNLPTLIRAEERLRRSVLPMSGYPPLGKPYLLIEYIDPSRGKSLSETWKEGRHDTELRSNFFHSLSRVILALARTPLPKIGSFTLDGDGYLILSNRLLTMQIQQLENEPIPAGLPRNLTYASVDAHICDRLAFHESRLRRQPNAIIDIPDGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNU9</accession>
    <name>A0A9X0BNU9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_007272</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787672.1">
        <property type="nucleotide sequence ID" value="XM_056936873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNU9"/>
    <dbReference type="GeneID" id="81627122"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="175"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5477128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="222" mass="24721" checksum="98C02E53526FAA02" modified="2023-11-08" version="1">MWSWFGGAAAQKRKEAPKNAILGLRAQLEMLQKREKHLENQIAEQDAAARKHVTTNKNAAKAALRRKHQHEKNLEQTSAQVVQLEQQIYSIEAANINHETLQAMKSAGEAMKQIHGGMSIEQVDETMDKLREQHMLSQEIGDAITSMPLGEQMDEGELEAELEGMEQEAMDERMLNTGPTPVGSRLEGLPAAGATELNKPQAKNEEEDEEAELAKLRAEMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNY9</accession>
    <name>A0A9X0BNY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787894.1">
        <property type="nucleotide sequence ID" value="XM_056937095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNY9"/>
    <dbReference type="GeneID" id="81627344"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="69" mass="10078" checksum="ACD095BA0BC74F97" modified="2023-11-08" version="1">MWESTRYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYHLSLRYRNFVARMDLQSRCGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSM2</accession>
    <name>A0A9X0BSM2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Protoheme IX farnesyltransferase, mitochondrial</fullName>
            <ecNumber evidence="13">2.5.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_006665</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Converts protoheme IX and farnesyl diphosphate to heme O.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ubiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="13"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788201.1">
        <property type="nucleotide sequence ID" value="XM_056936266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSM2"/>
    <dbReference type="GeneID" id="81626515"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000004">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016315">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001773">
        <property type="entry name" value="COX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="11 13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="370"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="38"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5480771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="491" mass="53780" checksum="4D932286C802661D" modified="2023-11-08" version="1">MGVATYQGSSVFHKTYYFSANRLYDATGLKGGFTSSFISTTSEPSSSSPRNPNIPSDVPNEIVNTSQSESSNSTVAEDIHNELPHRRRKRLKTLAAQETQAAEPVIPLDASAQLSKLSSSLPQTSIRRKLAAYLALTKPRLSFLIVLTTTSAYGMYPISSLLALDPSIAPLPTLSTSTLTFIYLTVGTFLSCCSANTINMMLEPKYDALMSRTRNRPLVRGLVSRRGALLFALGTAVTGLGLLYVGTNPTVTALSAANIVLYGFVYTPLKRISVINTWIGAIVGGIPPLMGWVAAAGQTATTGHDTWRDMLLSEDSIGGWLLAGILFAWQFPHFNALSHLIRDEYKAAGYRMLCWVNPARNARVALRYSVLMFPISIGLWWVGVVGQGFLVGSTIANGWLVREAYRFWQHQGAQGSARGLFWASIWQLPILLVGGLVTKKGLWDGLWRKIFGQPEDDDDEYLYYDDEEEAELLRKEAATASSKQNGLLTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BT23</accession>
    <name>A0A9X0BT23_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fructose-1,6-bisphosphatase</fullName>
            <ecNumber evidence="5">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">D-fructose-1,6-bisphosphate 1-phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_006140</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FBPase class 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788666.1">
        <property type="nucleotide sequence ID" value="XM_056935742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BT23"/>
    <dbReference type="GeneID" id="81625991"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000009">
        <property type="entry name" value="Fructose-1,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000001">
        <property type="entry name" value="Fructose-1,6-bisphosphatase class 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF1">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="14">
        <location>
            <begin position="21"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="15">
        <location>
            <begin position="218"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5482694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="355" mass="38821" checksum="3317D7D52F8B1A92" modified="2023-11-08" version="1">MSSNGNGGAVGNENVNLDIVTLTRFFTEEQTKYPEASGDFTLLCHALQFSFKSIAYYIRRASLINLTGLAGSSNTTGDDQKKLDVIGNDIFISAMRGSGKCRLVVSEEEEEVITFDEHPNARYAVVCDPIDGSSNLDAGVSVGTIFGIFQLPEEIVGEGKKVGPEALRLPGTELVAAGFTMYGASAQLVITMRGGGVNGFTLENSLGEFILTHPNMKLPETRAIYSVNEGNSMYWDDWCNEYFDSLKRPGEGQKPYSARYIGSMVADAYRTLLYGGIFAYPADKKSPKGKLRILYECAPMAMVFENAGGLAVNSRMERLMEVCPESIHDKSGVFLGSKGEVQKVIDMYNKHHKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BT56</accession>
    <name>A0A9X0BT56_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="10">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_006245</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Also plays a role in response to carbon starvation and the control of extracellular proteases activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with creA, creC and qutD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="10"/>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788771.1">
        <property type="nucleotide sequence ID" value="XM_056935847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BT56"/>
    <dbReference type="GeneID" id="81626096"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000075">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase creB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="54"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="245"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="551"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="590"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5482799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="782" mass="87336" checksum="5F2850049343B6A4" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BU77</accession>
    <name>A0A9X0BU77_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_004877</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATPase d subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789673.1">
        <property type="nucleotide sequence ID" value="XM_056934479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BU77"/>
    <dbReference type="GeneID" id="81624728"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5484889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="173" mass="19226" checksum="4958D5B6C711F37A" modified="2023-11-08" version="1">MAARSAALKIDWAKVSTSLGLRGQTAASLQAFKKRNDDARRKVQALSEQPQTVDFSHYRGILKNQAVIDEIENHFKSFKPASYDVSRQLKAIDAFEAQAVQNAEQTKGKIDSELVNLQKTLENIETARPFEDLTVDEVASAQPEIDEKTASLVSKGKWMPPGYKERFGDLSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUD3</accession>
    <name>A0A9X0BUD3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789480.1">
        <property type="nucleotide sequence ID" value="XM_056934286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUD3"/>
    <dbReference type="GeneID" id="81624535"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5484696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="270" mass="29673" checksum="1E6A659F1067322D" modified="2023-11-08" version="1">MSLSPEDEDALPDLSFTTFNATGRTTVVLIHGALVSGLYWDLVCPYLPSSYHLLVPDLPGHGSSRAITPFTVNLSSRLIANLIRAHAVNGVAHVIGHSLGAQIAIRLAATEPSLVSSIFISGFGMFPRTALTPYIPYAAWTMPRLENCLPRSWVRWAMDGADLPRIDPETCTLDLCRQIVSPESPTQWPAPWPARTLIVAAGKGGLIPSNDQSHTAVRLMQIGRELNPETIAYTHPQMRHPWNRQAPQLFAETAEAWIEGRELPEGFIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUI2</accession>
    <name>A0A9X0BUI2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">propanoyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Propanoyl-CoA C-acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_006005</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.176" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789479.1">
        <property type="nucleotide sequence ID" value="XM_056935607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUI2"/>
    <dbReference type="GeneID" id="81625856"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="11">
        <location>
            <begin position="23"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="12">
        <location>
            <begin position="294"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="461"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5484209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="487" mass="52702" checksum="F4F4290B91597A5B" modified="2023-11-08" version="1">MSAQASPSDAYILGVGLTQFLKPRRTREYPELGYEAAVKALIDAKVNYDQVQQVIACYCYGDTTCGQRIAYSLGMTGCPVLNVNNACATGSTGLHTARRLIQGGLVDCALIVGFEQMRPGSIKSVWDDRPSPLGPSTKLMEDTFGKHDAPRNAQYFGNAGQEYTQKYALSSDQARVKNLMLHRWLTLPSAVPRYGAQPDDFAEIARISHEHSQKNPYAQFRQAYSLDEILKSTPVYGPLTKLQCSPTSDGAAAAVMVSQRFLDARPSLKSQAILIAGQALLTDGPEVYSGSAIDLVGFQMSREAARLALQEAGVCIQDIKVCELHDCFSTNELLLLDALGFSEPGKAHEMVRRGDITYGGKGPVVNPSGGLISKGHPLGATGIAQCAELTWQLRGWANNRLVPGVHVALQHNLGLGGAVVVTIYKRADGKVSNSVSDEEVKHVSGLGYNPAVEAHYIRPQDGERVRSKSKSHDYPLRGVNDKLASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUL0</accession>
    <name>A0A9X0BUL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_005267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790063.1">
        <property type="nucleotide sequence ID" value="XM_056934869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUL0"/>
    <dbReference type="GeneID" id="81625118"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5485279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7907" checksum="D2B7F3B8CB4512CC" modified="2023-11-08" version="1">MAMHNWPQSVTKDTRALFNDVEEFFGGPFFNAEEAFFSFVRHMLTWLPQRRKTARELMDHAFLKLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUM8</accession>
    <name>A0A9X0BUM8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_005327</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790123.1">
        <property type="nucleotide sequence ID" value="XM_056934929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUM8"/>
    <dbReference type="GeneID" id="81625178"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034737">
        <property type="term" value="F:ergosterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008204">
        <property type="term" value="P:ergosterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF23">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="314"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5485339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="621" mass="70790" checksum="FF73F82BBFB9D539" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXC8</accession>
    <name>A0A9X0BXC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_003556</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790699.1">
        <property type="nucleotide sequence ID" value="XM_056933158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXC8"/>
    <dbReference type="GeneID" id="81623407"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="40"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="139"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="291"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5488666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="382" mass="40623" checksum="AFF3300513D894DE" modified="2023-11-08" version="1">MSEVAQTESSIAGGAGNSTTSNTAVDTTKSGGTVKTRSVDYVLRSGLAGGLAGCAAKTVVAPLDRVKILFQASNPQFAKYTGSWAGLSAAIRDIKRYEGARGLFKGHSATLLRIFPYAGIKFLAYEQVRAIVIPSPEKETAIRRLLSGSLAGITSVFFTYPLELVRVRLAFETKKSSRSSLTDICRQIYNERAALPSTGAAVSAGGQTTSATIATAETVAATVNQVVPRSGLANFYRGFGPTILGMLPYAGVSFLTHDTVGDWLRTPAIAQYTTIPASESKPKKGSRQPQLTATAELFSGAVAGVVSQTSSYPLEVIRRRMQVGGAVGGGQRLGILDTGRKIWLERGFRGFWVGLTIGYIKVVPMAATAFFVYERLKWSLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXV4</accession>
    <name>A0A9X0BXV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerases I, II, and III subunit RPABC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_003769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790912.1">
        <property type="nucleotide sequence ID" value="XM_056933371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXV4"/>
    <dbReference type="GeneID" id="81623620"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000191">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000779">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5488879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="143" mass="16148" checksum="5CCCF6D587E5666B" modified="2023-11-08" version="1">MSDPVLFEDTFTINSINAQKYDRVSRLECENRDKSITFTLDVNTELYPCAVGDSVRMAIASTLSHDGKEDSRTSWREVSNGEPSLADNYDYVCHGKVYRFAEGTEKDTMAVFASFGGLLLYLVGPYAKTNPLRIDHVYLLMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY77</accession>
    <name>A0A9X0BY77_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein mL67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_003993</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL67 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791136.1">
        <property type="nucleotide sequence ID" value="XM_056933595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BY77"/>
    <dbReference type="GeneID" id="81623844"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024629">
        <property type="entry name" value="Ribosomal_mL67"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184">
        <property type="entry name" value="MITOCHONDRIAL HOMOLOGOUS RECOMBINATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12829">
        <property type="entry name" value="Mhr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="239"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5489103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="336" mass="38725" checksum="3F8C18EDFE26D73F" modified="2023-11-08" version="1">MASASAASKPIQKILDSTRVASLKKFVRHPPIDPKTPIQGKIRETSSNAFKEHLKRESVRLQKALNSITHGKHIFVYHNAQTKQVVYSLTRYLEENNVLRQMVYHGKKTVPAKLRRDMWIPYYSVHFGDARLGLRAYQLLREFSLRRQLSPPPEMVTVSEEFLASRRPKDPTEAEEFDRLNKKRIGHPMEKKERARVLMDQKATSVADVAAVLEIQEKEIADGILDKEQWRHKQFPSQRRRQREAIAQEAERAEEYNARIEALERQLSEREGVEVKIGEIGDYPETAGDVKILWRDVHDANYAASWPAKVQHGELELKRDNIIGGERVDILPTVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYD1</accession>
    <name>A0A9X0BYD1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
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<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792093.1">
        <property type="nucleotide sequence ID" value="XM_056932134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYY8"/>
    <dbReference type="GeneID" id="81622383"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000282">
        <property type="entry name" value="Glyoxylate reductase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="90"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="157"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5490964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="365" mass="39304" checksum="F4B9EEA968EEBA96" modified="2023-11-08" version="1">MSASRASARLSLLESAISPRSPSDQTLSSIVKSSNMIASQSALLIGGITHARPEWEALSSILTLKEFPSGTRQEFIENCKAGHYDDVVAIYRSNTSNKFTGNFDAELLSILPKSIRYICHNGAGYDNIDVPACTRRNIAVSSTPVAVNNATADLGIFLMIGALRQAYVPITAIREGKWHGQTTTGHDPQGKILGILGMGGIGREMASRAKAFGMKIQYHNRSRLPADLEAGATYVSLDELLANSDVLSLNLALNASTRHIIGAPEFGKMKDGVVVVNTARGALIDEDALVTALDSGKVRSAGLDVYEEEPKVHPGLLSNPRVMLLPHIGTNTFETQKEMEILVLNNLKSAVEKGELITQVPEQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ04</accession>
    <name>A0A9X0BZ04_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_002842</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792404.1">
        <property type="nucleotide sequence ID" value="XM_056932445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ04"/>
    <dbReference type="GeneID" id="81622694"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="13">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="14">
        <location>
            <begin position="163"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5491275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="213" mass="24218" checksum="C3A58A62A6FB47A4" modified="2023-11-08" version="1">MTLYYSLVFLLLVFEMAVFLALIVPLPFTIKRKLFAFISESPIIAKLQYGLKITFIFILILFIDSVNRVFRVQQELAAFAKDGSAVSAAHLGTDRMEVQARKFYSQRNMYLCGFTLFLSLILNRTYIMILEVLRLEDRVKLLEGNKNAGGKDSARIAEAGNLGEIGSLKKQLAEKDRDIETLKKQCEGLTREYHKLGDEVSSSKSDKTEKKDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ78</accession>
    <name>A0A9X0BZ78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_002801</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792363.1">
        <property type="nucleotide sequence ID" value="XM_056932404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ78"/>
    <dbReference type="GeneID" id="81622653"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000217">
        <property type="entry name" value="MFS lactose permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF36">
        <property type="entry name" value="LACTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
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</entry>
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</entry>
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    <sequence length="102" mass="10359" checksum="3D1FE532EE02D1C1" modified="2023-11-08" version="1">MKHFVALSLLAASAIALPTEAGGKMSQGKKPSNEQPACGSQQTVVCSGNGNGGLLSLGNILTGLLGENCSGGDVYCCSEEAVNQVGLINLDLNLQCSLNHLL</sequence>
</entry>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038896">
        <property type="entry name" value="NAPE-PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="95"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="285"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine</name>
            <dbReference type="ChEBI" id="CHEBI:62537"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine</name>
            <dbReference type="ChEBI" id="CHEBI:62537"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR038896-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5492926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="380" mass="42148" checksum="DF34F8F4FD366C1A" modified="2023-11-08" version="1">MGSTTTAVLYTLSVASSPARAAPNDASAKSHHAKAGFRNPWERRITGKANKPKTTGPTVTVRKPDFLPTRDTPRLRATWLGHACYYVEFPGGLRALFDPVLEERCGPYNMLGPKRFTEAPCKINDIPVIDAVFISHNHYDHLSYTGVTEIAQRHPNCHFFVPLGVKAWFQSCGISQVTELDWWDERDITLSPVGNEEAQVGVVEDSASVAAGIKARIGFLPSQHATARTPFDRMQTLWGSWTIESGGKHVYFTGDTGYRSVPKLPEGEDDHDPKYDNLPTCPAFKQVGEFRGPFDLGLIPIGAYAPRHMFSSAHVDPHEAVQIFQDTKCKKALGMHWGTWVLTEEDVLEPPEKLKAALKNFGLPVEGVFDVCEIGESREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2G0</accession>
    <name>A0A9X0C2G0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="16">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_000547</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Protein phosphatase that specifically binds to and dephosphorylates the molecular chaperone Hsp90. Dephosphorylation positively regulates the Hsp90 chaperone machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="16"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794444.1">
        <property type="nucleotide sequence ID" value="XM_056930151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2G0"/>
    <dbReference type="GeneID" id="81620400"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07417">
        <property type="entry name" value="MPP_PP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000389">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000039">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041753">
        <property type="entry name" value="PP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 15" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="17">
        <location>
            <begin position="278"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5495431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="477" mass="54142" checksum="E5612322A8AB230E" modified="2023-11-08" version="1">MASAQEEANALKLKGNKAFAEHDWPTAVQFYDQAIEKYDKEPSFFSNRAQAQIKLEAFGFAVADATAALELDPNYVKAYWRRALAKTAILDYKGALRDFKAVVQREPNNQNAKIKLAECEKLVRRLNFEKAIEVSDPPSAFEGLDIEAINVESDYDGVRLGSEMTQEFIDDMIQRFKDGKKIHRKYVFQIIKAVKEIVYNEPTMVEVGVDAGKKLTVCGDTHGQFFDLLEIFRRNGSPSESHAYLFNGDFVDRGSWSCEIALLLYAYKWLRPSGLFLNRGNHETDDMNKVYGFEGECKAKYNERVFKVFSESFSALPLATLIGEKYLVLHGGLFSDDKITLNDIRKLNRHNQRQPGQQGLMMEMLWTDPQPQPGRGPSKRGVGLQFGPDITKRFCENNGLEAIIRSHEVRMEGYEVEHDGRCITVFSAPRYCDSTENKGAYINIGPDLKLNYEVFEAVPHPDIKPMAYAQNSILSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2M2</accession>
    <name>A0A9X0C2M2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_000426</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794323.1">
        <property type="nucleotide sequence ID" value="XM_056930030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2M2"/>
    <dbReference type="GeneID" id="81620279"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="183"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="319"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5495310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="953" mass="106464" checksum="AA15A09DE809616F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2P2</accession>
    <name>A0A9X0C2P2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase chyC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794277.1">
        <property type="nucleotide sequence ID" value="XM_056929984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2P2"/>
    <dbReference type="GeneID" id="81620233"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="259" mass="28487" checksum="F3C54B8587568E2A" modified="2023-11-08" version="1">MVRILITGSSDGLGLEAARQLIQRNHTVYLHARNQQRAEEARAKCPGAAGVLIADLTTMAETKKLAEEANAIGTFDAVILNAGMFHGDYRKTPDFGMPALAFVNVIALYSLVCLLNRPKRLILISSTLHKQAKTDLKDPFWLERGEKGFQVFQAYCDSKFHVLLLAKAAARRFKGTSVTAVHPGWIQTKMGGAGATDNMQDGIDTYLMLAEGDYDQSVTGVYFEPKRKLAESLPAGDDEHLQEQMVQACEELTKLTLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2P8</accession>
    <name>A0A9X0C2P8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794845.1">
        <property type="nucleotide sequence ID" value="XM_056930552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2P8"/>
    <dbReference type="GeneID" id="81620801"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039683">
        <property type="entry name" value="Lsm12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019181">
        <property type="entry name" value="LSM12_ABD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13542">
        <property type="entry name" value="LSM12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09793">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00995">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="2">
        <location>
            <begin position="126"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="244" mass="25712" checksum="E3B81C787E8AF4A4" modified="2023-11-08" version="1">MAENKRQTTTAKGSLNASSASTASGTATNMVPLEAALSGAIGARVRLTTSATPASTFEGVLFTACPITNLVAINTSPAASTADAKLASSGDYHVIPVSRIQNFQLLAAPSNSSDGPSFADAIPSIQALDLRSLRTREAKAVGEAMDREARRGKGVTREAQDIFDAFSRTMPAHWNGPNIVVADSVSIAPPYRVEDCRPLVAGNDAALMRVQKVLEMERKKIEFRNASATIGSTSTFTRNERKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2T9</accession>
    <name>A0A9X0C2T9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">40S ribosomal protein S9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_000621</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794518.1">
        <property type="nucleotide sequence ID" value="XM_056930225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2T9"/>
    <dbReference type="GeneID" id="81620474"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000004">
        <property type="entry name" value="40s ribosomal protein s9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="7">
        <location>
            <begin position="86"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5495505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="170" mass="19426" checksum="CD85E68DB08C986B" modified="2023-11-08" version="1">MGARPVPDAELKLIGEYGLVNKREVWRVQYTLSKIRRAARLEENDPKRLFEGNALTRRLVRQGVLDQSHMCLDYGLSLRPEDFLERRLQTVIFRLGLARSIHHERVLIRQRHTRVGKQLVNVPSFMVQLDSQKHIDFTLNSPFAGGRSGRVARKKARDGTGSGRDAAEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKU4</accession>
    <name>A0A9W9WKU4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_008967</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785939.1">
        <property type="nucleotide sequence ID" value="XM_056938562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKU4"/>
    <dbReference type="GeneID" id="81628812"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07102">
        <property type="entry name" value="ALDH_EDX86601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5469349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="467" mass="50917" checksum="A946E48F2587FA43" modified="2023-11-08" version="1">MSNQIKTVNPATHEIIFDQPGTSVEEARKLATASRRAFQSWRTVSLEDRIAIVKRALEIIDSRIDDLAKELTIQMGRPVRYCAGEIKTAALRAEHMIKIAKQSLADLPGEPQEGFRRMVKQVPVGTVLVASAWNYPYLTTVNALVPALLAGNTVLLRPSPQVPIFGQGLAEAFTEAGLPQDVLQVLQIGSLDVLDQIVQIPEIHSVSFTGSTAGGIRLREATAKQVKPVHLELGGNDPAYVRPDVDVKNVAENLVDGAVFNSGQSCCSVERVYVHEKVYDEFVRCVQEELKGYKLGDPLDQTTTTGPVVSALAKEKIQSHVDDALKKGAVDATPENESFSLAQTSQKGNFVAPVVLTNVNHDMLTMKEETFGPVMPIMKVASDEEAISLMNDSDYGLTASVWTKDIARGEELIDQIEAGTVFINRCDYPAPDLAWTGWKMSGLGCTLGPRGFDGFVKLKSYHIKNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKU8</accession>
    <name>A0A9W9WKU8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetyltransferase ats1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_008889</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785861.1">
        <property type="nucleotide sequence ID" value="XM_056938484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKU8"/>
    <dbReference type="GeneID" id="81628734"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000086">
        <property type="entry name" value="Acetyltransferase, GNAT family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5469271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="175" mass="19566" checksum="1A632692E4E1E5BD" modified="2023-11-08" version="1">MATSQPTIRLATPEDVPYILQFIRELADYEKALHEVEATEASLLATLSFPNDPPKRGSVYTALVIPPPSTENPSPVPVGMALYFYNYSTWRSAPGIYLEDLYVQPAARGSGYGLKLLRFLAKQVLEINGRRLEWSVLTWNTPSIEFYKQVGAKPMDEWLKMMVDGPALEKLAEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL51</accession>
    <name>A0A9W9WL51_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Single-strand DNA deaminase toxin A-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_009137</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786109.1">
        <property type="nucleotide sequence ID" value="XM_056938732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL51"/>
    <dbReference type="GeneID" id="81628982"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057517">
        <property type="entry name" value="SsdA-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24120">
        <property type="entry name" value="SsdA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Single-strand DNA deaminase toxin A-like C-terminal" evidence="3">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="154"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5469519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="236" mass="27273" checksum="9C0A023CE72566BA" modified="2023-11-08" version="1">MLVLRMEELHERMQHSLVDAKMSKLSSETAQTYYFREEPAQIGHGSRSSQLPEQTRRMQSQCRGMTRYLHVTDDSVIENTYKREIDPQENVRLLGGENSKSNLTSGGPPTLVVSHHVPPDKAEDHDRDSQFKACHAEKQLITYFTDPHVFLPPNSKLETSVQVKEEELEKLLKSTRIDQQIAFLERKKRDLQKELFDGDEKLVREDVEIQAMKLELKPVETALNHQATRQKPKVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLJ7</accession>
    <name>A0A9W9WLJ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_009250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786222.1">
        <property type="nucleotide sequence ID" value="XM_056938845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLJ7"/>
    <dbReference type="GeneID" id="81629095"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14364">
        <property type="entry name" value="CUE_ASCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052586">
        <property type="entry name" value="ASCC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041800">
        <property type="entry name" value="ASCC2_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494:SF0">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 ASC-1 COMPLEX SUBUNIT P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="374"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5469632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="742" mass="80321" checksum="CE837E625C7BE495" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLL2</accession>
    <name>A0A9W9WLL2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_009045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786017.1">
        <property type="nucleotide sequence ID" value="XM_056938640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLL2"/>
    <dbReference type="GeneID" id="81628890"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016445">
        <property type="entry name" value="Rog1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005412">
        <property type="entry name" value="UCP005412_abhydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="308"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="448"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="262"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="635"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="735"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="827"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="951"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="750"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="838"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="960"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1019"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5469427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1035" mass="114115" checksum="A1C4BDE90B220670" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLM1</accession>
    <name>A0A9W9WLM1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_009324</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786296.1">
        <property type="nucleotide sequence ID" value="XM_056938919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLM1"/>
    <dbReference type="GeneID" id="81629169"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10917">
        <property type="entry name" value="CE4_NodB_like_6s_7s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF6">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040825647" description="NodB homology domain-containing protein" evidence="8">
        <location>
            <begin position="30"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="9">
        <location>
            <begin position="290"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5469706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="491" mass="55363" checksum="B9FB947760D1645B" modified="2023-11-08" version="1">MRSCLSLKFLLPLFWLSISLTAISRSTLGRPGKSPWEHPHWLETRQARSLTSNTSRSGQPLVIDTFQDFDQNDLGFWHGTGEDLETEHEPGVMRLFPSDPDQNFHTQLNSQGCFSLSPWANQFLHVVFEGNREFTVSLNEHNAECNAARLPFPGTADSVQSSRYLLETAQPEGKGVGTSDAKRGSSSTQPMPEPGPQIDDISQVHDTKHQANGALQTGRLELYIPLSHFHVNLDRLISVSLNGFYTDEPIALHRIEIVPTVPAPSDENDNFTLPKKLPTGTLVLRCKRPNSFAFGIDDGQPQFAQEVMQILDDEKVRATFFVVASGLRDETTNFTAFYREMLSKGHQVALHSNTHPKLEELQDLDEIDDEIIQSIETLRNELQVASKYFRPPFGTVGARLRQELAKYIDNPTIVNWSVDVEDWLWANSDTPERQLDAFYRGVARGGNLAVMHYLHPSTVTYLRPFIHYVKSQGLQIMRVDQCLEDPTSPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLP5</accession>
    <name>A0A9W9WLP5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007689</name>
        <name evidence="1" type="ORF">N7539_009354</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787155.1">
        <property type="nucleotide sequence ID" value="XM_056937290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLP5"/>
    <dbReference type="GeneID" id="81627539"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5469736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="126" mass="13950" checksum="E023A10028FF7485" modified="2023-11-08" version="1">MNEQLHDESHKLPVEARNLTIIAMFLHRDVWVRREGQDLKPIEESGAFEEGFMEGLSPIGTIIDGQDGLQHWQIKVAIPSLRGFLATAVGKPSDLSEMVVLRKPANGIITNTGIDGTEVFSSHPYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQM7</accession>
    <name>A0A9W9WQM7_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786340.1">
        <property type="nucleotide sequence ID" value="XM_056938332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQM7"/>
    <dbReference type="GeneID" id="81628582"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="85" mass="9266" checksum="E77DAF3AC65CA491" modified="2023-11-08" version="1">MASNKDSKGKAREETSFQLGFSASNAGPLQEQGKASGERCGKSYGPESFKIPNAAEETRLTEAAKVSAEKRQHVTEKISKEYRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQU2</accession>
    <name>A0A9W9WQU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_008468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786445.1">
        <property type="nucleotide sequence ID" value="XM_056938063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQU2"/>
    <dbReference type="GeneID" id="81628313"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="406"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7779" evidence="3">
        <location>
            <begin position="677"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="845"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5471899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="921" mass="104316" checksum="AE7DC7327524A80A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQX6</accession>
    <name>A0A9W9WQX6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008582</name>
        <name evidence="2" type="ORF">N7539_008616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786559.1">
        <property type="nucleotide sequence ID" value="XM_056938177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQX6"/>
    <dbReference type="GeneID" id="81628427"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5472013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5472047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="60908" checksum="387024AA3F62D3A2" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUA8</accession>
    <name>A0A9W9WUA8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NIPSNAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_007743</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787209.1">
        <property type="nucleotide sequence ID" value="XM_056937344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUA8"/>
    <dbReference type="GeneID" id="81627593"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000004">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000037">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="3">
        <location>
            <begin position="182"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="NIPSNAP" evidence="3">
        <location>
            <begin position="288"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5475456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="387" mass="44288" checksum="6A6E458383039EC5" modified="2023-11-08" version="1">MLGPRLIRPATTALARPFSSSVAAYRAPSIRDLTADSTEEFNRRQKEFRENLEEARKRKELQESQSVDASASAPASFSFTSSDSMSRESAPTAPHVSNASFYDRVRPAYDAAETLDNGALGSLAMHRYLGDETTAESGSKRGPLSSLIYGTKEGQHFDKDIERSFSQVLARGKYVHSIVFHEVKPDKVDEYVELVGKWYPRMAGDEENRVHLVGSWRTQVGDNDTFVHIWEYQRYEGYHASLHNIASHPEFPEFDRKLKSLIKSKKTSLMQEFSFWPTTPPRKLGGLFELRSYTLHPGNLLEWETHWRRGLHARREVMEGVGAWFVQIGDLNTVHHLWQFANLEERKVRREQSWGVEGWAETVHKTVPLIQNMQSRILVPMPWSPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUF7</accession>
    <name>A0A9W9WUF7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_007765</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787231.1">
        <property type="nucleotide sequence ID" value="XM_056937366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUF7"/>
    <dbReference type="GeneID" id="81627615"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="7"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5475478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="452" mass="49829" checksum="24AE69365738DBDE" modified="2023-11-08" version="1">MQNLENLQIAIIGAGMGGLTTALALAKRGFKSIDVYENAQDLGFVGAGIQLAPNMARVLDGLGVWRRIEAEAVDITETSVRDGATDNELAHVELGYIEKTYGYKHMVGHRASLAGGLYEGCKKQPAIKFHFGINAEYVEFGSRPSFIAVPRKQGEVSFRVECDVLLAADGIKSLARQEMLKRLNVHTGVRDTNQAAYRIMIHKDKLKDDPELLALINSTRVTRWIGAKRHIIAYAVSNNTIYNLSTIQPDTNFAAATNATYTTKGSKSAMMQVFDDFCPMVKRLLNYVPEGEVCEWKLRVHDPLPTWVHENVALLGDACHPTLPHLAQGAAQAIEDGAVIAAALSRLPDTTPDSINKALRVYEKVRKSRAETLVEMAAASGRALHLGDGAAKEERDRQFAALRQGKGPVPDKWADADVQREIYGFDCIKVTEERFDEYFGQMDNTPRDSKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUK1</accession>
    <name>A0A9W9WUK1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787547.1">
        <property type="nucleotide sequence ID" value="XM_056936748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUK1"/>
    <dbReference type="GeneID" id="81626997"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38646:SF1">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38646">
        <property type="entry name" value="YALI0F00814P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15207" checksum="BE28E0935B885429" modified="2023-11-08" version="1">MFERRAADRYRLRMHRARSAVLTNDEIVEVRAAQRTFEGAYVRTALSQFSFALVVLKIFTAEFYSIGALFAIYGTGVLIIGLFRRSQGNRQFFSVMGDDGVHRHKFRTSGNAVVVLTALSIAAYACLIGLTLHLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUL2</accession>
    <name>A0A9W9WUL2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MRH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_007170</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787570.1">
        <property type="nucleotide sequence ID" value="XM_056936771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUL2"/>
    <dbReference type="GeneID" id="81627020"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.130.10:FF:000024">
        <property type="entry name" value="Putative vacuolar sorting receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028927">
        <property type="entry name" value="Man-6-P_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02157">
        <property type="entry name" value="Man-6-P_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="11">
        <location>
            <begin position="144"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="396"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5477026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="447" mass="47765" checksum="A0E3958F1ECF9AF3" modified="2023-11-08" version="1">MPRLGAAAPAGGCAAPPVRLSASPNEVVTDVEKRVCAAVPTSNRSAVGFTKPPTDIIPRRAGLLDEFTSSIPQPTSSFTKQHLSHSFFSLPDLQFFNSLDFHNPPFVMKWFISATGSLLLLAGSAASAFAAAASDKSAHHSETKPCVARSPTSGLFFDLNAISLTPPESKNGQKTVKDAREESWHARGHDYPANFTINICAPVVERVKDVVGVDSARWKNVSAFYEQAGKIYSIGEQASEPFFRGRKLVLNYTNGSPCSDDVKSAGKNASMRTKSTIMSFLCDRDAPANQATPSFVGTMDSCTYFFEVRSSAACGGVAADPSAGGLGPGGVFGVIVLIAVAAYMIGGCAYQRTVMHQRGWRQCPNFSLWAGMVDFIKDMFVILFSSLGRCLRLNRSSSSGDYSRASGDGRSGIMGAFGGRGSAGSGSRRDVDAENRLIDQLDEEWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUL8</accession>
    <name>A0A9W9WUL8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_007128</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5476984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787528.1">
        <property type="nucleotide sequence ID" value="XM_056936729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUL8"/>
    <dbReference type="GeneID" id="81626978"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000057">
        <property type="entry name" value="SNARE complex subunit (Bet1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5476984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18123" checksum="AAA3F78BA922F18B" modified="2023-11-08" version="1" fragment="single">FPRQRDPRPSSSLFDSYGGGASSRPASRSPASVGGYGYGGYAGPAATAYPNTNGNAGFRSVTPDKKGHYSDAVLSSLESQNDAEVEGITAKVKMLKDMTIAIGDEIRDTSYINTLENSFESTRVRLRGNMTRMLRMAERTGISWKVWLAFFFAVFLLFFYVWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVV9</accession>
    <name>A0A9W9WVV9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_007641</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788041.1">
        <property type="nucleotide sequence ID" value="XM_056937242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVV9"/>
    <dbReference type="GeneID" id="81627491"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="543"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="661"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="814"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="543"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="684"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="697"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="824"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5477497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="833" mass="93641" checksum="BF27C72600F37B2F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1L9</accession>
    <name>A0A9W9X1L9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788176.1">
        <property type="nucleotide sequence ID" value="XM_056936241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1L9"/>
    <dbReference type="GeneID" id="81626490"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054448">
        <property type="entry name" value="HTH_put_ascomycetes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22943">
        <property type="entry name" value="HTH_68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-turn-helix" evidence="2">
        <location>
            <begin position="183"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5480746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="231" mass="24592" checksum="1EC7AC44BD252E63" modified="2023-11-08" version="1">MGSAASKPAKSAAGAAARRQYPKQAPVPPRVPSTAAKTSQATQAPSPPTPEFAPRSQSQAPPSGPKYHSEEQPSSHKTSGISWTSLTITRVTKHHTDFCATALAIDLDGRDPHFAASLRNLGPVTPSPTLSNSSTVNRGPMQSVFPSASNPALLALAARQRVAEAAQKEFDELAHGSQAGRQFLDAFTISQALTMRDQQKMAKRDIERSLRMKEGVMDQLGKDGLVSRVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2A8</accession>
    <name>A0A9W9X2A8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Eukaryotic translation initiation factor 4E-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_007028</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788564.1">
        <property type="nucleotide sequence ID" value="XM_056936629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2A8"/>
    <dbReference type="GeneID" id="81626878"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 4E-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5481134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="237" mass="26477" checksum="5FAF3F849F00E84B" modified="2023-11-08" version="1">MAAVAENGHAVTDENPATKVDTTSDGAATIFHDPENFKVKHPLMHEWTLWFTKPPSGKGDNWNDLLKEVVTFSSVEEFWGIYNNITPTSELGLKADYHLFKKGVRPEWEDPQNKHGGKWSYLFKDKRSVPIDDLWLHAQLAAIGETLEADGDNEVMGVVVNVRKGFYRVGLWTRTVGKSIPGDKATRTPAQGKEILEAIGRRFKDVLRLKEADVVEFSGHTDSAHSGSTRAKAKYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2W8</accession>
    <name>A0A9W9X2W8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein VAC14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788924.1">
        <property type="nucleotide sequence ID" value="XM_056936000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2W8"/>
    <dbReference type="GeneID" id="81626249"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5482952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="250" mass="28640" checksum="7CC511570BF58028" modified="2023-11-08" version="1">MDRQLTKSVSTLKINLTAAQRVLSSSELLSRILFWDAPSHKAELWEYDWIFPRDRFIKYALVNSIWFHEAMRFVWWNGLSVAKLGALDSMAPLRRALYLKYVVQVNFHNDSRGQFASVQNRIWRGLRFPALRVATLHVRPAQRLLSLPEIRAPNLEKLTLKVVAASNLQDPIALCDERTRQRLTARIAKMFPHLRKMTIMLPRGTTLKPSDVQHLQESLPGVDISIGSAELEYEHRGNELSLACASGVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3E3</accession>
    <name>A0A9W9X3E3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_006960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET117 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788496.1">
        <property type="nucleotide sequence ID" value="XM_056936561.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81626810"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031568">
        <property type="entry name" value="Pet117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15786">
        <property type="entry name" value="PET117"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
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            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5481066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="10175" checksum="28B44FB85B95B152" modified="2023-11-08" version="1">MSRASKLTLAATGLGTAGIIYFVHWTQENDRKAMHRGVERDMEKQRIRQERQAEFELQKRLEEEYLKLQTVHSTTETPGVGTQKTSPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3E5</accession>
    <name>A0A9W9X3E5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anthranilate synthase component 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="1">
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            <begin position="236"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5482915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="525" mass="57895" checksum="A846027391AB3EA8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3U6</accession>
    <name>A0A9W9X3U6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GET complex, subunit GET2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_006195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788721.1">
        <property type="nucleotide sequence ID" value="XM_056935797.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81626046"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Get2/sif1"/>
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        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263:SF1">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08690">
        <property type="entry name" value="GET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="211"/>
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    </feature>
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        <location>
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            <end position="84"/>
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            <end position="146"/>
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            <begin position="18"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
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            <end position="45"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="4">
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            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
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            <end position="141"/>
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    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5482749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="29931" checksum="51952A5A461C8450" modified="2023-11-08" version="1">MSTPEESPAQRAARLRRERREAKIKEGGSARLDKITSLSGRTPQSVREEASPSPQPAASPSPSPVPQMRPPPSYQSEAPPPDSLQAQQEAFRAMLRQVVPEQGQDSNDVQDPTLKLLENLIGGMPGDANAAPSGAPGAMPGQSQPGLSPAAIASALGVPPFLANMLGGASPPPTESAQNVQRAWKVLHTLFALGLAVYLLFMIAASVATFGSPPPKPATAQNPFLIFVTGEMVLSGGRVLHGSTQAGLGMVIQLFKDISRDGSLILFFLGLAAWYNREWQAVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X4K1</accession>
    <name>A0A9W9X4K1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000007">
        <property type="protein sequence ID" value="KAJ5483822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789092.1">
        <property type="nucleotide sequence ID" value="XM_056935624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X4K1"/>
    <dbReference type="GeneID" id="81625873"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5483822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="311" mass="34996" checksum="FCB3EE7DD4F0E2DB" modified="2023-11-08" version="1">MDTIITNLPPNVGAILIENISIIQIISMFSIGAYNALETGIAVFDSFKHYRGLYFWSIYDTIPISVIQPGHVNSIHFGVLRWVLWMIVINFSVLHIPMTVLFYGLNSGQSVFARPAAIYDRIQVTGFCMQEFVLSGDRKIIRHLLWINILVVLMNLLLLVAEYKLHYIEVSLKTVVYSIKLKLEFTVLNRPRKLGFTSPPPLAHQIPEYARQESDVNLVGRSRLHSRQESNSESVRTECGIKVPPRVSQRPSIQANREAKCDAQSDDTRVRGAIPSSNELTAPSACSSDQLTTSLSTLELNLSNFTSKFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X4T2</accession>
    <name>A0A9W9X4T2_9EURO</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">N7539_006057</name>
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    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X4T2"/>
    <dbReference type="GeneID" id="81625908"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5483857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="96" mass="10982" checksum="5A460977C1B84EB6" modified="2023-11-08" version="1">MGQTPIYQVVGMKNGSIEKWECSIYPDKDDTSMSHRMFHQPTSLYSTVINLPADKEVNRYGRKSSYIDAGFRGLENTEETNGDRPEDQGNTTWIMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X4Z3</accession>
    <name>A0A9W9X4Z3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein mesA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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            </authorList>
            <dbReference type="PubMed" id="36726175"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="entry name" value="Actin_polarity_regulatory"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5483962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="789" mass="87966" checksum="6D6C28E180F3B187" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9W9X574_9EURO</name>
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                <person name="Nielsen M.R."/>
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                <person name="Frisvad J.C."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="1"/>
            <end position="78"/>
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            <begin position="1"/>
            <end position="19"/>
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            <begin position="22"/>
            <end position="33"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5483840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="78" mass="8688" checksum="265E966396307615" modified="2023-11-08" version="1">MPDKNKPSAERRDGTKLEEESPQTLTAINQGSSNREKGRRGLIRWSLLQPTGHEPERISVGTAIGLKGPGNGKRKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_056934378.1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336:SF20">
        <property type="entry name" value="DUF218 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="110"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5484788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="286" mass="31673" checksum="CD67D663966F6685" modified="2023-11-08" version="1">MDGRLKDPNVACDGITTLDSSTIADINTLAAFLSNCELEDLSSVPSADCIVLCASQVLYGAEKIFDTLQARPGLAKCLVLCGGIGHSTNLLYSAVGQHPRYSRLFHSIQDLPEARVLEKILNEFFDRAAIEADGCRILIEEKSTNCGQNASESRQVLSQAGFSAPSTCIIAQDPTMMLRTKASFERVYQDAPFSVEFLSCPLLVPKLHISKAGVLEYQNKTIVPGMWTFDRFIELIMGEIPRLRDDEEGYGPRGRDFISHVDLPSEIEAAWSRLFDTFKDTKVLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5Y6</accession>
    <name>A0A9W9X5Y6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789727.1">
        <property type="nucleotide sequence ID" value="XM_056934533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5Y6"/>
    <dbReference type="GeneID" id="81624782"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5484943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="80" mass="9171" checksum="3731F26A2C7EE297" modified="2023-11-08" version="1">MILGNRTRELIFYPRSREIIVAEWKCLRDQESTEMGNATKNPKEVIALLAQLTRPEDQPSAVQSLLASSTKRLRWASENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5Y8</accession>
    <name>A0A9W9X5Y8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_004860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789656.1">
        <property type="nucleotide sequence ID" value="XM_056934462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5Y8"/>
    <dbReference type="GeneID" id="81624711"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="247"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5484872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="441" mass="47313" checksum="1235B24566380051" modified="2023-11-08" version="1">MEVKASFSDDSQSYDDTNLSLSLETTKPTVLDTLPPIDGGAHAWLFLAASATIEALVWGFAFSFGVFQSYYREREMFSQSDNVAVIGTCATGVAYLGCPLMITIMILLPRHARWFSTIGMTLMCLSLAVASFSTTFTHLVLSQGIGFGIGGCIAYSPSILFMSEWFDKKRGLAFGIVWAGSGLSGILIPLALDKLLGNFGFRTTLRIFSALMFVLAAPLLYFHKPRLPVPKQTQYERLNLRFMFSRISIIYQLGCVAEALGFFLPAIYLPTVARLQGASSLVASLTVTALNLASVFGSVSMGHLSDRCATGTCVAISTLGTVLSVFLLWGLSTSLPILIVFGVAYGLFAGSYSAIWSGMIRDIQKVNPEADATMIFSTLAFCRGVGNVVSGPLSEALIHADHWQGHAIGPYGQGFGLVIVCTGLTALVGGSSLVAPLFQWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X688</accession>
    <name>A0A9W9X688_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790037.1">
        <property type="nucleotide sequence ID" value="XM_056934843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X688"/>
    <dbReference type="GeneID" id="81625092"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="142" mass="16744" checksum="6E5FE146982A3B17" modified="2023-11-08" version="1">MRRSEAKKRVKRVKRVKRVKRVKEESEESEESEESEESEESEESEESEESEESEESEESEESEESEESEESEESEESEESEESEESEESEESEESEESEESEESEESEESEESEESEESEESEESEESEESEESEESEERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6E0</accession>
    <name>A0A9W9X6E0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="17">1.1.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Cytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Flavocytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">L-lactate ferricytochrome c oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">N7539_004972</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="17"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789768.1">
        <property type="nucleotide sequence ID" value="XM_056934574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6E0"/>
    <dbReference type="GeneID" id="81624823"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000009">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="6 22" id="KW-0349">Heme</keyword>
    <keyword evidence="12 22" id="KW-0408">Iron</keyword>
    <keyword evidence="9 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="23">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="24">
        <location>
            <begin position="107"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAJ5484984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="493" mass="54456" checksum="222A734984C7FF8F" modified="2023-11-08" version="1">MAKVRIISTDEVSKHRTSEDCWIVVDKQIWDVTNFLDEHPGGANIILKYAGRDATEAYSTVHAPSVLRSNLASELLKGELDESTIDKDWLKPPPSENRQVVVRHEKPPLETLINAHDFEVVASKTATPKTWAFYSSAATDLITRDANKSCFDRIWFRPRVLRNVRTVNTHSKILGHNCKLPLFVSPAAMAKLIHPDGECAIARACQRKGIMQGISNNSSYTSEELRSAAPTASFFFQLYVNRDRAKSAALLRQCSDNPNIKAIFVTVDAAWPGKREADERVKADEGLSVPMSPSKAQNDKKGGGLGRVMAGFIDPGLTWEDLRWVRQHTHKPVCLKGVMSADDAMLAMKAGLDGILLSNHGGRNLDTSPPSIITLLEIQRRCPEVLDRMEVYVDSGIRRGTDILKAICLGATAVGMGRSMLFATNYGQDGVEHLIDIMQDELETAMRNVGITSLEEACPDLVHTGDIDHLVPSSRTHPYARAVAKGRRVTSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6N1</accession>
    <name>A0A9W9X6N1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA pseudouridine synthase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA pseudouridylate synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA-uridine isomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_005451</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790247.1">
        <property type="nucleotide sequence ID" value="XM_056935053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6N1"/>
    <dbReference type="GeneID" id="81625302"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="17">
        <location>
            <begin position="425"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="342"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="611"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="634"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5485463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="649" mass="72618" checksum="F3421D61586170A9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XBT2</accession>
    <name>A0A9W9XBT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_003380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790523.1">
        <property type="nucleotide sequence ID" value="XM_056932982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XBT2"/>
    <dbReference type="GeneID" id="81623231"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000630">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="8">
        <location>
            <begin position="48"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="9">
        <location>
            <begin position="223"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5488490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="356" mass="38244" checksum="B3CC3A006BB98258" modified="2023-11-08" version="1">MPLRSTASLQRSARLHLATAVRRWPTGPTALNPVRSFSKTALRSKTWGFIGLGQMGYNMARNLRTKIPVSDTLMIRDVNEAAVERFVGEAREMGGQVEVARNAREVAEKSTVVITSLPQPQHVIDVYHSILHGGKLPELGEERLFIDTSTIDPVTSKDVAKAIHTSQTGHFVDAPVSGGVVGARAGTLSFMFGASAQAEHLLEQIQGILALMGKKAWHLGEPGAGVSGKLANNYMLAINNIATAEAMNLGIRWGLDPKNLADMINSSTGRCWPSEVNNPVPGVVETAPASRGYEGGFGIGLMNKDLRLALAAAQSSDTPLALGESAREVYNAVEEAYRGKDFSVVYQWLKNKSKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XC29</accession>
    <name>A0A9W9XC29_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pinin/SDK/MemA protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_003520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790663.1">
        <property type="nucleotide sequence ID" value="XM_056933122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XC29"/>
    <dbReference type="GeneID" id="81623371"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="2">
        <location>
            <begin position="79"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5488630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="156" mass="17791" checksum="B103C1B3EC6302F3" modified="2023-11-08" version="1">MSEGTLASAVAVPEQEAPTQSPETSTKRRQSSASVQDSKRRRLSSQGDLSPNVRRPQHSPGSPVRERPAERRPIRQGGEEDRKRGQRLFGGLLGTLSQSSSTAAQRRRADIEKRQQEKLKSQADEYDGLKKRRRERRDKIRQRKLRSMNGRRYAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCI7</accession>
    <name>A0A9W9XCI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_003745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790888.1">
        <property type="nucleotide sequence ID" value="XM_056933347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCI7"/>
    <dbReference type="GeneID" id="81623596"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22756">
        <property type="entry name" value="OTU_OTUD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="83"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5488855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="546" mass="59937" checksum="4B9A2DC941595777" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XD25</accession>
    <name>A0A9W9XD25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetraspanin Tsp3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791207.1">
        <property type="nucleotide sequence ID" value="XM_056933666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XD25"/>
    <dbReference type="GeneID" id="81623915"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29967" checksum="D8EF745AF986D28D" modified="2023-11-08" version="1">MPFKIDATTLLYIVLVVGGAISLILGALSWARTAALLLPLPTWVPATATFISPLTVLTLIAMRVFFQQTDHETPRNCWRSTISGILNQIQTIISTIVATVALAYIFPDSILSCNLDQKWQAFFQSKNSHAIRSIQDEFRCCGLRSLHDRAWPFKDRNHGDNACELQLGYQRSCFAPWREHQQSSSWMVFAAAVSVFAAKIALIRLSGRRTSWMSRQSACRRPDYHRISHPAVQDEGDIQNGAHGEAQRTFLPQSNTEYRNDWEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDR1</accession>
    <name>A0A9W9XDR1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">rRNA-processing protein EBP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_003883</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791026.1">
        <property type="nucleotide sequence ID" value="XM_056933485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDR1"/>
    <dbReference type="GeneID" id="81623734"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="255"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5488993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="370" mass="41924" checksum="FC963504C2A25932" modified="2023-11-08" version="1">MVKRSKLLQTLDAHRGRDYNAEKQKKMIKAAKKRKSTVQNDAGAEVTKKLEEKKQVAESESEDEDEEENDEQVEGETDEDEEVDVEAEDNEDEDNEEEDDDEEEEEEDIPLSDLEEDEREDVVPHQRLTINNSAAIKTSLKRISFINQNTPFSEHNSLVSKEPIEVEDANDDLNRELAFYKVCQAAAIEARGLLKKEGVAFTRPGDYFAEMVKNDEHMDKIKKKLYEEAAGKKAAAEARRQRDLKKFGKQVQVAKLQQRAKEKRDTLEKINTLKKKRKADTSAPTDDANDLFDVAIEETGKPEKRNREGGPNAKRQRRDQKFGFGGKKRFSKSGDAASTGDMRGFSQKKMKAGASKRPGKSKRAAAKGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDR3</accession>
    <name>A0A9W9XDR3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pumilio domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_004394</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791537.1">
        <property type="nucleotide sequence ID" value="XM_056933996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDR3"/>
    <dbReference type="GeneID" id="81624245"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000167">
        <property type="entry name" value="RNA binding protein Jsn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000339">
        <property type="entry name" value="RNA binding protein Jsn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052645">
        <property type="entry name" value="Pumilio_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093:SF1">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="486"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="9">
        <location>
            <begin position="627"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="6">
        <location>
            <begin position="689"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="6">
        <location>
            <begin position="725"/>
            <end position="761"/>
        </location>
    </feature>
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            <end position="800"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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            <end position="210"/>
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        <location>
            <begin position="244"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="564"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="978"/>
            <end position="1050"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
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        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
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        <location>
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            <end position="302"/>
        </location>
    </feature>
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            <end position="316"/>
        </location>
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        <location>
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            <end position="578"/>
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            <end position="995"/>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5489504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1198" mass="128941" checksum="C37E290D678CFCB7" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE54</accession>
    <name>A0A9W9XE54_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_004524</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
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        <location>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="430" mass="47436" checksum="7995A1A55936C7FD" modified="2023-11-08" version="1">MAALMAEPAGPPLAEDLELSKLEGKRHSACDECRKRKLKCSGELSGCVRCSKQSIHCVYSLQKPMGRPPKKRARSDEESGDVSVQGNTIWPTPQLTPPESLSSENDANMPTDASYICPQFFMHPSGQSQSPESNPSADDEETSPNWRPERSKNRNLPVPGTSSPWPDFTTVSQSSSMLFPAPTNSLDPTSLMMTPPMSNLIDPLGPKCTCLSYLYLCLSHISSLASFPVNSHTLCSLYIAARTALDVIRCDSCPKSFATGVQNVMFTGTLLTVVADAWLRVYNSDPMELGKQSAPPEFVSKAAQCPDQPEVWRNWLRQIVRQAVVGGYLDPEAGTRCSKQRDLLSLIRELEERQRRWHTPGQHPLSECNPMHSKAAGQPRADPDEDNDEKELLCIRVVGSARSVLTKFNFKPQDFPGGVIPDDMARLMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEV4</accession>
    <name>A0A9W9XEV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">N7539_004332</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056933934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEV4"/>
    <dbReference type="GeneID" id="81624183"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13 20" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="17">
        <location>
            <begin position="40"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="237"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="499"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="19">
        <location>
            <begin position="603"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="14">
        <location>
            <begin position="709"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="15">
        <location>
            <begin position="1091"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ5489442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1248" mass="139512" checksum="594D057858803CAF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF05</accession>
    <name>A0A9W9XF05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-1,2-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792035.1">
        <property type="nucleotide sequence ID" value="XM_056932076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF05"/>
    <dbReference type="GeneID" id="81622325"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5490906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="52182" checksum="15E916C637DD6915" modified="2023-11-08" version="1">MALKPSLESLLSSLSLVDLVRLVPVLSLCICILVFMLKKWQTSYRLTQSLGSAEGEVSSSKMHGREKTKRKWGEWKPSSFKRPAACPYSDWDVHSSNPIPYRPFRYGPTYSVTMGLRSMEWDEWIGKKSYARLFRHLERDTFVLMFFEFILNEELDNQYLKYHSGRNRRIAERGEKCFGTAPEAMDGAIELLEELCEYLPERYPTMFQKTPTGISNALTGETFDITQRPLPEDPMATAARLIQDDLAIMVERADGEYYLLAGAILLAGFWRFRDKFGMPLSEIHTSGNVPQYQEKLQRGMRNFFRRLKPEEPMLRNNYFIQVDDNLAWSHSIGSEDSETVSWNTAAKNKAVEHHFFRSERQSLRRLPRSGVVVFTIRTYFEPVTEIVKEPYVPGRLASAIRSWGDDVSRYKGREKYAEVLLEYLDQKHEEQVQAGLDIEEEDLIRKYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF48</accession>
    <name>A0A9W9XF48_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_002643</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792205.1">
        <property type="nucleotide sequence ID" value="XM_056932246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF48"/>
    <dbReference type="GeneID" id="81622495"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000005">
        <property type="entry name" value="Prefoldin subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5491076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="137" mass="15827" checksum="D9BD98B07FA43B86" modified="2023-11-08" version="1">MIQPRMLSRADEATATGEENEVRREDQEKINRFSRLHQRESVLEEQLKSKQKDKEDLEEISTELELADEDELVPYKIGDAFFHLPLPDAQSMLETSTAQIDADVSKLEDSLGELRDEMQQLKVSLYARFGRSINLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFH7</accession>
    <name>A0A9W9XFH7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792439.1">
        <property type="nucleotide sequence ID" value="XM_056932480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFH7"/>
    <dbReference type="GeneID" id="81622729"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="27"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5491310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="328" mass="35610" checksum="645BAD0DF7D70DC5" modified="2023-11-08" version="1">MSSSSREGGGPSRRRESRSGSRKVSSLSAEQLERKRAMDREAQRSIRQRTKEHIEQLEQQVVLLRTQVDSMRSQNQQFDDIIRQNATLQDEIARLKTQLSSLTGPSSFTSNPEQTVPQRSGWDVAERSHGSASAAAVPTSNTIMSPQFPSSAHQLSTRLPRQPSSMSVSSRSHPHEWQQSYSSTRSSSIGDSSDPEFPPRMEAYALEGHLQQPGPRMAAPTAPLVSSQMNFGGAGAGSMNHSGADSSFGQAYQVAHHSGPGAGGDGVPNMSSYHPDHRTMPLSMAGMNAPSQGNPTPPYQPASAPYRTQHGPAQQRDPSFSYPWNSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFN7</accession>
    <name>A0A9W9XFN7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792508.1">
        <property type="nucleotide sequence ID" value="XM_056932549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFN7"/>
    <dbReference type="GeneID" id="81622798"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23814">
        <property type="entry name" value="UEV_AKTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="12"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5491379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="336" mass="37098" checksum="638DEDC0C07BE1FC" modified="2023-11-08" version="1">MSTTRLPCIPSLRKQQLHLEFASLRRAAPPGLYVTLAPGDPTLWSGVVFVRSGPYASAILRFQIRFPDTYPDLPPLVTFATDVFHPLIVPLTTYTFSTGAASDDPVSATDEERLPPGGFSLRHGFPHWFGRAKRTDLVSGKSTRNLSGQSFKVTPETRSTSGEADTNSVEASDSTASTEQPADQVLTDDLPTRISQTPVVIPSHQPRPHVPVAELLAYVRSTFEDEEVLDSLPQDAAGNSGAWHAWRAHRRGTLGATRSTRDSSQARLPGDWHWDGIWARRVRDEIEASRSDAMLFGNSTRGVGEETIRFSRMDETTRALVKERMKMTIAEVTSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFV2</accession>
    <name>A0A9W9XFV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792307.1">
        <property type="nucleotide sequence ID" value="XM_056932348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFV2"/>
    <dbReference type="GeneID" id="81622597"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="69" mass="7671" checksum="65905025CFF6935E" modified="2023-11-08" version="1">MAFLFELHRKVDSAILGTWALYSQANLKEVVANFSRDYHATHFPTSLLSTETSSPAPVRPPAANEQLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFW5</accession>
    <name>A0A9W9XFW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tat-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_003087</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792649.1">
        <property type="nucleotide sequence ID" value="XM_056932690.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81622939"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140674">
        <property type="term" value="F:ATP-dependent histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05491">
        <property type="entry name" value="Bromo_TBP7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001218">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000016">
        <property type="entry name" value="ATPase family AAA domain-containing protein 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="72" mass="6990" checksum="B76EF2620E37B634" modified="2023-11-08" version="1">MQRRGSDAGPPDYSYSGPQSPSGGAGAGAGAGAHVPVAASTTTRSLRCSSNDGTALPGPPAVTGHGRLRAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIC7</accession>
    <name>A0A9W9XIC7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793535.1">
        <property type="nucleotide sequence ID" value="XM_056931504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIC7"/>
    <dbReference type="GeneID" id="81621753"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13300">
        <property type="entry name" value="DUF4078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5493155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="376" mass="42753" checksum="6D863205AC396B6B" modified="2023-11-08" version="1">MSSDQSSLYGKSRSKTTKTQEISSSSNLAFTSQLSSLINNNSTKIAQGRPRPSKAAKSDIFSKHNKGASKRAAADLQDDDRHVFNQVHRQSGDLGTIDEATLNRSKQRMIKKARLYEDMKKGVHLVNGDSDDDEDDGGDDYISRLRRKEKAGLVDFDTKWADEQRKKADRDGEEEEEEEEEEEEEGGGENDGDDDDENASVISFEDEFGRTRHGTRAEAAHAARIRDEEENRGRVAKTERWRPSRPDHLIFGEIIQTHAFNPDATIAAEMARLAAQRDRSPEIENTHYDADAEVRNRGTGFYAFSQDEEERKKQMAQLEESRMETQRRRDLLLRRAAEREAVVQERRRQIQELRARRLSEMTSAEMASTESAAGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIE5</accession>
    <name>A0A9W9XIE5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793849.1">
        <property type="nucleotide sequence ID" value="XM_056931818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIE5"/>
    <dbReference type="GeneID" id="81622067"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF1">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="102"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5493469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="240" mass="27078" checksum="D1B88A7DAE514935" modified="2023-11-08" version="1">MVGSSEPVVIPDCASRHPGGYPSAPTDTEAWELQQIQTREDDEQLNYSSASASSGEEYRVTTRTVSRSSAQRPPPDRKGAWKVVHRFWTHQVAIIVPQKSNRDHLALERTFLAYMRTSVVVAMQGVLISQLFRLQRPQATHHPRLRFYDVGVPLAVACHLVAIIVACIGAFRFWRQQSAISRGKFTRRPIRRSHLCVPDFVSSTTNRFGLAQLILVTLILSVVILVEIDLYPSSLFRLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIK0</accession>
    <name>A0A9W9XIK0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_002006</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793640.1">
        <property type="nucleotide sequence ID" value="XM_056931609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIK0"/>
    <dbReference type="GeneID" id="81621858"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.30:FF:000001">
        <property type="entry name" value="Probable kinetochore protein ndc80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057091">
        <property type="entry name" value="NDC80_loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24487">
        <property type="entry name" value="NDC80_loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="14">
        <location>
            <begin position="118"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Kinetochore protein NDC80 loop region" evidence="15">
        <location>
            <begin position="454"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
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        <location>
            <begin position="387"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="591"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5493260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="731" mass="83444" checksum="5F2FCEA6903D9631" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XL02</accession>
    <name>A0A9W9XL02_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056929633.1"/>
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    <dbReference type="GeneID" id="81619882"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42089">
        <property type="entry name" value="YALI0F09427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42089:SF1">
        <property type="entry name" value="YALI0F09427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5494913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="182" mass="19844" checksum="46AF41D467F3B0BD" modified="2023-11-08" version="1">MLTTRDSPGPHLLLAQVPLTVSPFINLPASVTLPYTYKSIPNSLPQSVLVDPTNPEAKPRYVFSSTGEHAAHPDEILASCQSLEQHLKKTKTEAEKAIKSWEESIRERELAEKRRVAPGWLDRDEKLLQPSKAGSMSATRSQKAGSLLDSVSADQGSSSLPAMVPRDEGDELDRAFGGLDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XL86</accession>
    <name>A0A9W9XL86_9EURO</name>
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        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056929768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XL86"/>
    <dbReference type="GeneID" id="81620017"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acinus_RRM"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RSB_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031">
        <property type="entry name" value="SAP DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031:SF3">
        <property type="entry name" value="SAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16294">
        <property type="entry name" value="RSB_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="3"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="635" mass="69138" checksum="0778AE1C65C7638D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLL7</accession>
    <name>A0A9W9XLL7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_000403</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794300.1">
        <property type="nucleotide sequence ID" value="XM_056930007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLL7"/>
    <dbReference type="GeneID" id="81620256"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF25">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="9">
        <location>
            <begin position="49"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="8">
        <location>
            <begin position="265"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5495287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="436" mass="50166" checksum="EA4B08D06C5F48EE" modified="2023-11-08" version="1">MRSSCPARRWNGFRRVSQSRFYSSVREQQPPPWRPATALDEWAERQARPISLRQLTFFGRTLTEPRLISSANYVRTELPTRLAHRLRDIQQLPYVVVANPHLSLVYELYYKAFERFRVIPEIQSLDDNDRFCDILRDMLREHLVVIPNLAMGVLECRNLVSPNEMDKFMNTLLRARISRRVIAEQHLALTDTFNSPWHFQDSHDRTDLNADFVGEVFLKCKAKQVVERCGRVAQDLMRRTSSTAQLPEIIVQGHLDATFPYILSHLEYIVGELLRNSVQAVVEKYHDSPHPPPPIEVLICETPQHVIMRISDQGGGIPQEILPYLWSFSKGPRTQTRLENLGRVPAMAATMQELKVPERKVERDSWHEGSLDSLTSRPPNLRLGMGLPMSRVYAEYWAGSLELHSLEGYGVDAFLQICKLGNKNEQVTTRAAMDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLT3</accession>
    <name>A0A9W9XLT3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_000443</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794340.1">
        <property type="nucleotide sequence ID" value="XM_056930047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLT3"/>
    <dbReference type="GeneID" id="81620296"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF7">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040835064" description="Heme haloperoxidase family profile domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="25"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5495327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="248" mass="27529" checksum="184E13FAC0AA5720" modified="2023-11-08" version="1">MKVTIAVIAASCLGASASALPKDHPPVNWRPAGPSDTRGPCPMLNTLANQGFIPHHGRDLTEDEVVNGLKDSINLARDFSKTFYQAGLKTNLSPNATTFSLDDLSHHNILEHDASLSRRDYYSGNDHSFDQATFDQTRSYWQGDEIDVYHAALARQARVDTSNRTNPDFTFSEAAKGTTFIENSAYMLAFGDKTAGTVPKAWVEYFFQNEALPTELGWRRHDEEITSADLNDMSQRLAVATKQIQDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM50</accession>
    <name>A0A9W9XM50_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein fmp52-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_000151</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMP52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794048.1">
        <property type="nucleotide sequence ID" value="XM_056929755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XM50"/>
    <dbReference type="GeneID" id="81620004"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000366">
        <property type="entry name" value="Protein FMP52, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF7">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="7">
        <location>
            <begin position="8"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5495035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="229" mass="24531" checksum="17CBBEEDB62CACF9" modified="2023-11-08" version="1">MTTAAVFGSTGAVGSQILATLLASDSFAHVKTVSRRVPDVQSPKLEALQESDTSKWGTLISTLSPKPSVVFNAVGTTRATAGGIENQWKIDHDLCIENARAAKAAGVKTYVFISSAGTRGFFSKYVPYSKMKIGVEDAIRELGFEHAIIIRPGMILGREVPKSAVFESIVGNLHKVAQGIQDCLGQDQSIIGRAAVAAARQAEEGKAPSAYWIVEQADVVRLGRDEWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM69</accession>
    <name>A0A9W9XM69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794569.1">
        <property type="nucleotide sequence ID" value="XM_056930276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XM69"/>
    <dbReference type="GeneID" id="81620525"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="121" mass="13357" checksum="61B4A12814CB8028" modified="2023-11-08" version="1">MLRSASKPKLSLSIAAAQSAPRPTLSLKSPVPAPRTPISPASPAAKRFSTFQVPSYSYVNSCSSKSILKKTSSIGTNASNKRIEFQSSPTVYCVTPIENTDEYYGKHTKMSREERRWMARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM78</accession>
    <name>A0A9W9XM78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein sec72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_000196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794093.1">
        <property type="nucleotide sequence ID" value="XM_056929800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XM78"/>
    <dbReference type="GeneID" id="81620049"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:Hsp90 protein binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:protein folding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF3">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5495080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23253" checksum="322D2F7915F65E22" modified="2023-11-08" version="1">MASEIDIFNEYPLYMDPSTKAISLLPSSSQTASQKAAITAELTELNDLHRSLISLDSPNIPPPPLPVNPKRSAQITKLRDSGNAAYRKSNYADAIRLYTLAIEMAVSRPGWEPVTLAREELAGLYGNRAQAHLGMRAWPEGLCDAKASVDSKPVGNVKAWWRLSKCLAEMGRYTEAKTFLLKGIEIEGRESEGGRELVQLLGDVEAALQRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XME3</accession>
    <name>A0A9W9XME3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RNA binding protein Nrd1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_000699</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794596.1">
        <property type="nucleotide sequence ID" value="XM_056930303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XME3"/>
    <dbReference type="GeneID" id="81620552"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16984">
        <property type="entry name" value="CID_Nrd1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000026">
        <property type="entry name" value="RNA binding protein Nrd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000397">
        <property type="entry name" value="RNA binding protein Nrd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048892">
        <property type="entry name" value="Nrd1_Seb1_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21380">
        <property type="entry name" value="Nrd1-Seb1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CID" evidence="10">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="501"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="359"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="635"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="724"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="408"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="736"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5495583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="745" mass="78379" checksum="19F6BCDB89380435" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMH9</accession>
    <name>A0A9W9XMH9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_000401</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794298.1">
        <property type="nucleotide sequence ID" value="XM_056930005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMH9"/>
    <dbReference type="GeneID" id="81620254"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040915206" evidence="10">
        <location>
            <begin position="19"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="30"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5495285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="208" mass="23331" checksum="B774313A59412BF3" modified="2023-11-08" version="1">MRFALLASLASVVASVSATALTYKLEANEKACFFTNIEQANAKVAFYFAVQSGGSFDVDYTVTAPGGKVVLDGTKERQGDFVFTAQSTGEYQFCFNNEMSTFAEKMVDFEIAVENEQRAELPSRQGASPEQTSNLEESIYKLSAQLSTIARNQKYFRTRENRNFSTVRSTERRIFNFSVIESLMMVSMAALQVFVVRFFFQGARKGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMP0</accession>
    <name>A0A9W9XMP0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794807.1">
        <property type="nucleotide sequence ID" value="XM_056930514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMP0"/>
    <dbReference type="GeneID" id="81620763"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="127" mass="14183" checksum="049D701302931B13" modified="2023-11-08" version="1">MGLLRTAALVVLGISAFVFVALFGRLPVFRKTPIAFFHRLLWVHLPGGIAWIDSHLFGGRIVHAWNRSGSYILHENHPLVLVRNIPKNDTSNMILSHSRCFSSVCSASENVLLYQWHGLGFPMCTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XNE2</accession>
    <name>A0A9W9XNE2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_000555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794452.1">
        <property type="nucleotide sequence ID" value="XM_056930159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XNE2"/>
    <dbReference type="GeneID" id="81620408"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5495439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="500" mass="54241" checksum="F77E1E6A1894EF33" modified="2023-11-08" version="1">MPSEKIDKKRKRTSDRNERPTKKPSLQTLPTLAASVIEDKSELAPVIATTPGVLNSKDLRFNPYTKSRHNAERTATRNAGIVGAEMLLQSSEHEKMDFVGREGTGEDADSQLTHYVAVVDPERKTWQVIEARRVTVRGAVRSRKPVEEESEESEEEMNTMRAQRTNLTNTFGTKQSRKAVQSMAENAQLSNAPAGTLNEAGAALISTLPADVASGLAKASSVQAEVQAAKPLPTPDLTAAHPSDVYSLETLVPGGHSTLRQLTGVDEWVEQVESGLSIVTGSRYVSNRVVAVAQSGNTTQIQVLRFIQLLLEFARSLKGMGRDKGAGPGSKKLPPREDLRKILSSTSGAGATSTTKAGKEEDDSNLALLPDSVVDAVRRRFAPQGGFLSKHDLTLLHTTICALSFHIPPQPAKDGGSSSLGGNSPNELATDPSDLRDDLRLDSNTIQQYFRELGCRIDKPRESEFAKWNIKGGKAEAAARRIARLRIPLEFPKVSRGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XNI3</accession>
    <name>A0A9W9XNI3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Crh-like protein</fullName>
            <ecNumber evidence="19">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">N7539_000826</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="19"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794723.1">
        <property type="nucleotide sequence ID" value="XM_056930430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XNI3"/>
    <dbReference type="GeneID" id="81620679"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000152">
        <property type="entry name" value="Cell wall glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12 21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 25" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 23" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040777570" description="Crh-like protein" evidence="23">
        <location>
            <begin position="21"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="24">
        <location>
            <begin position="22"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="399"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="20">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="20">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAJ5495710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="476" mass="50128" checksum="CB7B2274F10C4454" modified="2023-11-08" version="1">MRLALSTAVSLLCSAVLVNSQTYTNCNPLQKSCPADTALGKTGQNYDFTAGSSVQFAASGAVAYDKTNGAAFTISKKGDGPLIQSGWYIMFGKVEFTIKAAPGTGIVSSAVLQSDDLDEIDWEWLGGDNTQVQTNYFGKGITSSYNRGAFHANSGNHDNFHTYSVDWTSSQIVWAIDGQTIRVLTPATADSNQYPQTPMMVKVGVWAGGDPDNAKGTIDWAGGVTDYSKGPFTMYLKSMTVTDYSTGNSYSYGDHSGSWESIISNGGKVNGNSGLEPTVAQPAPVITATVDSVPIPWSGTHRETSSFVTPDVWPWVATGSPTGYSGRLPPGWQSGSGHIQPPSSGSASEHCLPYISAYPTMTYAKSDNLLSQSFSQCTSAFSASSSGLRFPSGHKTVLNETRWTRPSSPSDTNKKHNHADHSQVDATTSMAPSTATGSPSPSHALSAGHGTSVYQGPAAITAVIIALLLGIPRAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XNY2</accession>
    <name>A0A9W9XNY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794722.1">
        <property type="nucleotide sequence ID" value="XM_056930429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XNY2"/>
    <dbReference type="GeneID" id="81620678"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050278">
        <property type="term" value="F:sedoheptulose-bisphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046390">
        <property type="term" value="P:ribose phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF15">
        <property type="entry name" value="SEDOHEPTULOSE 1,7-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="276" mass="30841" checksum="9CA737D3922A97E3" modified="2023-11-08" version="1">MTAPTTSARVFLVRHGDTDWISGGKFASRTDIPLSKMGEKDIEFTRDRVVAEDEMIDPTGIAKIYCSPRINARRTVEILGIGVHHHQHFQNEETGQKWRSESVIKGETADPYIHITKSLEEWDFGYYEGMTLQAINEKRMKDYGSGTWDIWTDGCPGGESPQQVTERLDKLIREIKQVISSNSASWPGGQLIAHRSQHAQDVVCVAHGHILAALAIRWVGLPLDTGMMRLIFEPGGVGILGFEHDNINQPAILVGRKPGRPDREQRSETGFAQASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XPS2</accession>
    <name>A0A9W9XPS2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_001245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795142.1">
        <property type="nucleotide sequence ID" value="XM_056930849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XPS2"/>
    <dbReference type="GeneID" id="81621098"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="4">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="539"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5496129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="604" mass="67181" checksum="6C66C93DBC0DF492" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ60</accession>
    <name>A0A9X0BJ60_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_009478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785795.1">
        <property type="nucleotide sequence ID" value="XM_056939073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJ60"/>
    <dbReference type="GeneID" id="81629323"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000260">
        <property type="entry name" value="Forkhead transcription factor (Sep1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="197"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="197"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="389"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="596"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="664"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="736"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="326"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="464"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="496"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="618"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5466749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="761" mass="84084" checksum="2AAC65E83E32B5FE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ92</accession>
    <name>A0A9X0BJ92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-3-dihydroxybenzoate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_009406</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785723.1">
        <property type="nucleotide sequence ID" value="XM_056939001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJ92"/>
    <dbReference type="GeneID" id="81629251"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000043">
        <property type="entry name" value="Amidohydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF31">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="65"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5466677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="338" mass="38842" checksum="4267B75AD8184341" modified="2023-11-08" version="1">MLGKIALEEAFALPRFQEKTRWWAGLFATDVEKHVAEITDVDSIRLNFAEKHGVGLQILSYTAPGVQDIWDPVDAQKLAVEINDYIAEKVKAHPDRFAAFATLSMHDPQEAADELRRCVKQYGFLGALVNDTQRAGSDGDDMIFYDNEKWDVFWQTCTELDVPLYLHPRNPTGTIYDKLWADRKWLVGPPLSFAHGVSLHTLGMVTNGVFDRHPKLQIIVGHLGEHIPFDMWRINHWFEDRKKLLGLRETCKKTIRQYFAENIWITTSGHFSTTTLNFCMAEVGADRILFSIDYPFETFEDACDWFDKMEISDTDRLKIGRENAKKLFKLGAYKDSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJK2</accession>
    <name>A0A9X0BJK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Molybdopterin synthase catalytic subunit</fullName>
            <ecNumber evidence="8">2.8.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Common component for nitrate reductase and xanthine dehydrogenase protein H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Molybdenum cofactor synthesis protein 2 large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Molybdenum cofactor synthesis protein 2B</fullName>
            <shortName evidence="8">MOCS2B</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cnxH</name>
        <name evidence="10" type="ORF">N7539_009303</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + cyclic pyranopterin phosphate + H2O = molybdopterin + 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26333"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="Rhea" id="RHEA-COMP:19907"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="ChEBI" id="CHEBI:232372"/>
            <dbReference type="EC" id="2.8.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MoaE family. MOCS2B subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.12" evidence="8"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJK2"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990140">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.40:FF:000003">
        <property type="entry name" value="Molybdopterin converting factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000003">
        <property type="entry name" value="Probable alpha-glucosidase (Maltase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000007">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="entry name" value="Molybdopterin biosynthesis MoaE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03052">
        <property type="entry name" value="MOC2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028888">
        <property type="entry name" value="MOCS2B_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF232">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 13 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="Molybdopterin synthase subunit MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="5 8" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="9">
        <location>
            <begin position="20"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="714"/>
            <end position="715"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="730"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="737"/>
            <end position="739"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5469685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="766" mass="87865" checksum="30D5EBEA101877F8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJS1</accession>
    <name>A0A9X0BJS1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_009246</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786218.1">
        <property type="nucleotide sequence ID" value="XM_056938841.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81629091"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000481">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000585">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="806"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1151"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="555"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="625"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="713"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1262"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1160"/>
            <end position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5469628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1479" mass="166045" checksum="7E5C684E6CB2B370" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BLJ2</accession>
    <name>A0A9X0BLJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786362.1">
        <property type="nucleotide sequence ID" value="XM_056938354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BLJ2"/>
    <dbReference type="GeneID" id="81628604"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5471816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="119" mass="14134" checksum="5FFB3071674A8A37" modified="2023-11-08" version="1">MDTKTRAKIMRHIVDLKRRFMSPHFPASGSLYHRRDLDSSQHVIPVLDDIVVGPTAQHEWWYQERASLEVYHGLSPAKRELEFCERFGKPRLHVERYLREIHQFQTSHLFSTNISLPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BMW8</accession>
    <name>A0A9X0BMW8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial outer membrane protein porin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_008040</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5474974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786732.1">
        <property type="nucleotide sequence ID" value="XM_056937640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BMW8"/>
    <dbReference type="GeneID" id="81627890"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000004">
        <property type="entry name" value="Por1 mitochondrial outer membrane porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00558">
        <property type="entry name" value="EUKARYOTIC_PORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5474974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="284" mass="29942" checksum="67509A0BEBE2C458" modified="2023-11-08" version="1">MSAPAAFSDISKAANDLLNKDFYHASPASLEVKSKAPNGVTFTVKGKSSHEGSIAGQLEAKYVDAPTGLTLTQAWTTANALDTKLELNNNIAKGLKAEILTQYQPAKQSKGAKLNLYFKQPNLHARAFFDLLNGPTANLDAVLGHEGFLVGAEGGYDVNKAAITKYSAAVGYSVPQYSAAITASNNLSLFSASYYHRVNAQVEAGAKASWDSTSGNTVGLEVASKYRLDPSSFAKAKINDRGIAALAYNVLLRPGVTLGLGASFDTQNLNQAAHKVGASFTFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BMZ8</accession>
    <name>A0A9X0BMZ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786939.1">
        <property type="nucleotide sequence ID" value="XM_056937847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BMZ8"/>
    <dbReference type="GeneID" id="81628097"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="321" mass="35236" checksum="C2C4DD6C8E4E57AF" modified="2023-11-08" version="1">MKGSLLESRWAPGNHDAYDQHEHPSYSYNKPSYHSVSAPQTSRSSNPPSQWQSKAPSHPPRTHSVPAPHTTSSSLPPPNTNNLLPPAEELARFMKIVSRLRWKLPFLAEAYRIATENTQPSSEAEIMFKIDFFEYYALLERAIVHLLAVFNITVSSAGAGGLPARGRSYNAGGGGTSTTGSYGGGDSGSALSRNGASTLHRYHANVLSALESETSPLTPVLGSGHVFEQLRQAKELRNRWKTADMTTEQLARDPVGNRDSVRPLESYDLEGILSAIFAGLEEGFMRARAHVELCKRPGEEVEEVKEGGWDFMVDAMDWEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNI7</accession>
    <name>A0A9X0BNI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA endonuclease activator Ctp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_007103</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5476959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787503.1">
        <property type="nucleotide sequence ID" value="XM_056936704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNI7"/>
    <dbReference type="GeneID" id="81626953"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013882">
        <property type="entry name" value="Ctp1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08573">
        <property type="entry name" value="SAE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA endonuclease activator Ctp1 C-terminal" evidence="5">
        <location>
            <begin position="537"/>
            <end position="650"/>
        </location>
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        <location>
            <begin position="172"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="323"/>
            <end position="367"/>
        </location>
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        <location>
            <begin position="410"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="627"/>
            <end position="647"/>
        </location>
    </feature>
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        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5476959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="685" mass="76705" checksum="353AC5509A8ABCFD" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNK8</accession>
    <name>A0A9X0BNK8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_007119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5476975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787519.1">
        <property type="nucleotide sequence ID" value="XM_056936720.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81626969"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="227"/>
        </location>
    </feature>
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        <location>
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            <end position="838"/>
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    </feature>
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        <location>
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            <end position="29"/>
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            <end position="77"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5476975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="922" mass="104812" checksum="770FB7BBA602C267" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNK9</accession>
    <name>A0A9X0BNK9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Borealin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_008383</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the borealin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056937983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNK9"/>
    <dbReference type="GeneID" id="81628233"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018867">
        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040:SF7">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10444">
        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin N-terminal" evidence="11">
        <location>
            <begin position="33"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="112"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5475317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="363" mass="38989" checksum="38738D2B51B72BE0" modified="2023-11-08" version="1">MATLKRKAPELSEASDATPTGRPVKKLRLTRSQKQALIDNLQLEITERARKLRAQYTLQAHDLRARLERRVNRIPVSLRKANMGELFEKYAAATQATSPIRRISPIKASRAPISIDQALSPSSTRDGRTRRTSNDGYSDKENAPAGGTPEGLKNPKRRGKAPAASGTSRIVSQEMRSNNHRILSPKSSNSRTYPQSPFRASPEKGQPSYLSRPISPLKPSSPLRAPAPGSRPRGATTSNVRDVPLSSQIKKTTARSATGPRAVNSPLPRPATRQGERKNSFSSTTSSGTTVAKQNKPGLVGRKATTGTAASTKKPPVPRAHAASLAVKKPTAATAASAVRKTTAPASTLESSTRATRALRKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNN4</accession>
    <name>A0A9X0BNN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Extracellular metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_007092</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the peptidase M43B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056936693.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81626942"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="METALLOPROTEASE MEP1 (AFU_ORTHOLOGUE AFUA_1G07730)-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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            <begin position="238"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNP5</accession>
    <name>A0A9X0BNP5_9EURO</name>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">N7539_007875</name>
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    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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            <strain evidence="2">IBT 30728</strain>
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    <reference evidence="2" key="2">
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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    <comment type="caution">
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    </evidence>
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    </evidence>
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            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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</entry>
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        <recommendedName>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">IBT 30728</strain>
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    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788364.1">
        <property type="nucleotide sequence ID" value="XM_056936429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSB6"/>
    <dbReference type="GeneID" id="81626678"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018256">
        <property type="entry name" value="Ribosomal_eL13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01104">
        <property type="entry name" value="RIBOSOMAL_L13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5480934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="219" mass="24924" checksum="5AD50D2C2A183731" modified="2023-11-08" version="1">MAIRHNNQIQKNHFRKDWQRRVRVHFDQPGRKHRRREARIAKAAAVAPRPVDKLRPVVRCPTVKYNRRVRAGRGFTLAELKEAGIPKKLAGTVGIAVDHRRTNYSKESLVDNVARLKDYKARLILFPRKSGQFKKLDSSAEDVKAAKSGEGLTKKVGASFPIVNPALEAAVSEVKRDSLPEGEKAAYRRLRDSRAEARHRGKREKRARVKAEEEQAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSN2</accession>
    <name>A0A9X0BSN2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_006229</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the annexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788755.1">
        <property type="nucleotide sequence ID" value="XM_056935831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSN2"/>
    <dbReference type="GeneID" id="81626080"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000005">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009117">
        <property type="entry name" value="ANX14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01813">
        <property type="entry name" value="ANNEXINFUNGI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0041">Annexin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5482783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="49532" checksum="177C8FA4C8CB0A2C" modified="2023-11-08" version="1">MSYQYPPHQQPPYGYPPSGGPPPPPPQGYQQPPFPQQQYGPPGGAPPPQSGYGHQLSYPPQGQPGQGYYGGPPPPHGAYPPPTHSPQPPQQYGHPPPGQHYPPPQGHALPPGPPPMHGGYPGGAPASNAYPAPPSLGYVPGQVAPGDFRAEADALRKAMKGFGTDEKALIQVLSRLDPLQMAGVRATYSQHIGRDLFKDVKSETSGYFEQGLLAVIEGPLMHDVTCVREAVKGMGTKEWLLNDVLLGRSNADLQAIQALYERTYGHSLAKDVEDDLSFKTAELFKMVLRATRHEDSVSLNPQSIEAEVRTIHDSTAARMVNNVTEVCGIFARSSNAELREISRAFEARYHASLEKHIEKEFAGHMEDALLHMLRTATNPAMRDAILLEECMAGMGTKDEKLVIRVVRAHWDRQHKDQVKRAYHHRYGRDLIDRVQGETSGDYKRLMVALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BU29</accession>
    <name>A0A9X0BU29_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General transcriptional corepressor ssn6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_005887</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CYC8/SSN6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789361.1">
        <property type="nucleotide sequence ID" value="XM_056935489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BU29"/>
    <dbReference type="GeneID" id="81625738"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000078">
        <property type="entry name" value="Transcriptional corepressor Cyc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000282">
        <property type="entry name" value="Transcriptional corepressor Cyc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="270"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="386"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="427"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="668"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="701"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="753"/>
            <end position="767"/>
        </location>
    </feature>
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        <location>
            <begin position="796"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
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            <begin position="811"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="835"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5484091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="844" mass="90696" checksum="64F38C9FA62915B4" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BU75</accession>
    <name>A0A9X0BU75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000007">
        <property type="protein sequence ID" value="KAJ5483879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789149.1">
        <property type="nucleotide sequence ID" value="XM_056935681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BU75"/>
    <dbReference type="GeneID" id="81625930"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5483879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="138" mass="14630" checksum="60F679D768EB37FD" modified="2023-11-08" version="1">MALSVPDSGITMSLVKGFLIQFVLWASTDTDAVLPNSSFTTVLHLVPGKKEEQAFRRIALILSLCGGVAIFRVSPGQMDTETADGTGGSTNGSDPPLNERPTGKDPCAILRRLGESANHDPVWSLSAASDARYPADTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUH3</accession>
    <name>A0A9X0BUH3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Uricase</fullName>
            <ecNumber evidence="7 10">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_005191</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 10">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>urate + O2 + H2O = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 10">Belongs to the uricase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="7 10"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789987.1">
        <property type="nucleotide sequence ID" value="XM_056934793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUH3"/>
    <dbReference type="GeneID" id="81625042"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00445">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.270.10:FF:000001">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.270.10">
        <property type="entry name" value="Urate Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019842">
        <property type="entry name" value="Uricase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874:SF1">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00366">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4 7 10" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009760"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5485203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="302" mass="33837" checksum="55A34D85D8234290" modified="2023-11-08" version="1">MASLAAARYGKDNVRVYKVHRDEKTGVQTVVEMTVCVLLEGDIETSYTKADNSVVVATDSIKNTIYITAKQQPVTPPELFGSILGTHFIEKYPHIHVAHVNIITHRWVRMNIDGKAHPHSFVKDSPETRTVQVDVTEGKGINIASSINGLTVLKSTGSQFWGFLRDEFTTLKETWDRILSTQVDAKWQWRRFNSLQEVKSNAHKFDGAWETARTTTLKTFAEDNSASVQATMYKMSEQILAAVPLVETVEYALPNIHYFEIDLSWHKGLKNTGKDAEVYAPQSGPNGLIKCTVARSGQKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUN7</accession>
    <name>A0A9X0BUN7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789840.1">
        <property type="nucleotide sequence ID" value="XM_056934646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUN7"/>
    <dbReference type="GeneID" id="81624895"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="172" mass="18892" checksum="6C2057BBF8919500" modified="2023-11-08" version="1">MSAQGPAALPPTTVLSTKPISQSEAHEFLAMYLERARTDASLQPNASINESGPVSRTTSAAPNLILHNLKRVQAGLAGEVLGRDLTVQKQNPGEDYLDIPTTEATQDQAENGEDGENNDLEMNDVEMETEAEAFAEQEEEQASVDKEERKRRKKERRLAEKKAKAKQADDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUQ7</accession>
    <name>A0A9X0BUQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_005089</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789885.1">
        <property type="nucleotide sequence ID" value="XM_056934691.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81624940"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="RRM_RBM25"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052768">
        <property type="entry name" value="RBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034268">
        <property type="entry name" value="RBM25_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806">
        <property type="entry name" value="RBM25 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="135"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="PWI" evidence="5">
        <location>
            <begin position="649"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
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        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="521"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
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        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
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        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
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        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
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        <location>
            <begin position="423"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="544"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5485101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="82382" checksum="07892F96E74609F5" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BV32</accession>
    <name>A0A9X0BV32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_005208</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790004.1">
        <property type="nucleotide sequence ID" value="XM_056934810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BV32"/>
    <dbReference type="GeneID" id="81625059"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5485220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="447" mass="49986" checksum="E9F7E7CCA5563773" modified="2023-11-08" version="1">MTQSYQQPQAALAGFLDSMHQDSSMSAYNLFGQYPESVAFWHDPTATVPPIGLAAPSYPPKQSAHLQPVGDQKKHKRTRSGCFTCRARRIKCDEARPVCERCRKGNRDCVYPSPTASSSKGSRSSTKSRGTRPLSQGSESSSKHDTEEMNPLEPILDEEEPEGTDLGSEASPRSGSGAGHPRQQLHRTQSGHSLRKRSVKQLSEAGSSQVEAGSSPSTESSRYESMSVRSGSFSHSILDLINNSRLAEDVRFYLDFHQQHLSYDHFFLRSSSAHFIHHSILELALGYDPLLYALWGKLYTFLKYYNKALVLLRKSLEAGEEHTEATLCTVLVLTVFEEYIGDWANLVDHHQAAHALMRELLTPDSSNMIDLHTNIFLWYARFDVVAGILAGTETILSRDWYIAKEQYDAQQAALYPDDPNKQLAYVASINRRFGLDMASLYAKLSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXP4</accession>
    <name>A0A9X0BXP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1308 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_003901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5489011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXP4"/>
    <dbReference type="GeneID" id="81623752"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF1308"/>
    </dbReference>
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        <property type="entry name" value="UNCHARACTERIZED DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UPF0415 PROTEIN C7ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07000">
        <property type="entry name" value="DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="DUF1308" evidence="2">
        <location>
            <begin position="365"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="579" mass="65090" checksum="54D3FB0AAA6B200C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXT3</accession>
    <name>A0A9X0BXT3_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5489131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="105" mass="11989" checksum="7CE246D2B0FA4079" modified="2023-11-08" version="1">MLPVRAPQSPQHQRTRPGWNFEIYSDPEEFTFPAGWPSSEEMNSEYRSAEDNKENRLFLAAATEARQPRRPPRQLDQSAVALGPRDAFGSPFLTRHSHHDDEAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY19</accession>
    <name>A0A9X0BY19_9EURO</name>
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        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056933415.1"/>
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    <dbReference type="GeneID" id="81623664"/>
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        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040779626" description="EF-hand domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5488923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="204" mass="22965" checksum="C8E6ED3E5E69C79C" modified="2023-11-08" version="1">MVSRLLLITASVLALSSGIVSAHGTHSSDGKPPSDDWATRHMIEEHHIEGFDALSFFTLHDYDSSGSWTPDEVRKTYGLDDESNKSASESSKESAVRAVFDLFDPRHTGLISRDNFVKTIAAGTRLPDLGFGPGHHGDLEYEYEIHHFEKFHGDDAKEEDLTHPEDIEHFRLHDELEAAQLRLDKLEDMQIVEANIPSKFRRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY53</accession>
    <name>A0A9X0BY53_9EURO</name>
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        <submittedName>
            <fullName evidence="9">Nicotinic acid-CoA ligase pyr1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_003918</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791061.1">
        <property type="nucleotide sequence ID" value="XM_056933520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BY53"/>
    <dbReference type="GeneID" id="81623769"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF317">
        <property type="entry name" value="ADENYLATE-FORMING ENZYME AFEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="45"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="8">
        <location>
            <begin position="480"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5489028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="606" mass="66817" checksum="4DA7CBA4618D7CD1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYJ2</accession>
    <name>A0A9X0BYJ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_002303</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791865.1">
        <property type="nucleotide sequence ID" value="XM_056931906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYJ2"/>
    <dbReference type="GeneID" id="81622155"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="10">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Prp18" evidence="9">
        <location>
            <begin position="222"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5490736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="309" mass="36355" checksum="103639AF2171B410" modified="2023-11-08" version="1">MDFAALMSKEISKAKAPATNKTTEASQEKPTLSEQPKKYMRRAEVEAARIDAYNKEQERLRREREEKLKNKRKLEEEEADRAREREEKKRRIAEEHKRKREEEEAKKERERRRRLGLPELPAKDERGETPASEDAEEDNIDEEELTKRLRALNEPARLFGENHRARLRRYRRLRKRAAMAKKMTDGPIPTILEPVPGGQMIIGSKPPKEKEAREFLFRQLASYFNMVLSEWELALAKRDVTVRESFQGKQAHNAMLQSRENLKPLFRRFEKGDLEDGLLEPIVEIVHKAQQRRYVDANDAYLRVSIGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZA6</accession>
    <name>A0A9X0BZA6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcriptional regulatory protein DEP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003068</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BRMS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792630.1">
        <property type="nucleotide sequence ID" value="XM_056932671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZA6"/>
    <dbReference type="GeneID" id="81622920"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1500:FF:000002">
        <property type="entry name" value="breast cancer metastasis-suppressor 1-like protein-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="536"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="636"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5491501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="675" mass="75149" checksum="965F79A64B8E0D2F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C058</accession>
    <name>A0A9X0C058_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Catechol 1-2-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_001506</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793140.1">
        <property type="nucleotide sequence ID" value="XM_056931109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C058"/>
    <dbReference type="GeneID" id="81621358"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="106"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5492760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="289" mass="32620" checksum="271A117A9FAA9A22" modified="2023-11-08" version="1">MASHRFNAQFTDNVINAMGPNTSPRIRQVMASLIRHVHDFARENEITVDEWMEGVKLLNWAGQMSDEKRNEGQLVCDVLGLESLVDEITFTLADEAKDAPTATAILGPFFRADTPYRQNGADIAVTKPKEGGEMVFMHGSVIDFKTKQPLAGADVEVWQASTNGLYEQQDPDQAEHNLRGKFKTDDEGRYYFYCLRPTPYPIPNDGPSGKLLTLMDRHPFRPAHIHILATKEGYRPLTTQIFDRQDKYLDNDSVFAVKESLIVDFVPRKEDPNASLELQYDVKLVADSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0C2</accession>
    <name>A0A9X0C0C2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793693.1">
        <property type="nucleotide sequence ID" value="XM_056931662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0C2"/>
    <dbReference type="GeneID" id="81621911"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5493313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="265" mass="30013" checksum="CD250BDFE4C1D2A1" modified="2023-11-08" version="1">MKFFENVFTYDYSFPAVSLAYFLRYPNPYSRHVLTTDVIDRYVDPQTQRLHTVRLHLKKSKVPSGILKLLPKGMSGSDSSGQSYILETTIVDPIEGWMETESRNMEWTGILSVVEKQRYQRQLTDGSEQTLDGLSIDKKEQTTVRTTVTFLSRLGQGKLLTRKKADSADQSDSEEEAPKKGFFSSLSTAGIQRTIELIGVSRTRDAIVKSKQGMNVVLERLRHGGIVGVLEGMRQDREAILGPDGPWKRVWMQGNGRVYNDDDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C202</accession>
    <name>A0A9X0C202_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_000183</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794080.1">
        <property type="nucleotide sequence ID" value="XM_056929787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C202"/>
    <dbReference type="GeneID" id="81620036"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000007">
        <property type="entry name" value="Lysosomal beta glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000009">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051915">
        <property type="entry name" value="Cellulose_Degrad_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30620:SF117">
        <property type="entry name" value="BETA-1,4-XYLOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30620">
        <property type="entry name" value="PERIPLASMIC BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040734676" description="beta-glucosidase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="13">
        <location>
            <begin position="701"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5495067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="782" mass="85187" checksum="D52C2BF83497E051" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C206</accession>
    <name>A0A9X0C206_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LCCL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_000097</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <location>
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            <end position="60"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="705" mass="77994" checksum="90E6B2AC25650F4B" modified="2023-11-08" version="1"> </sequence>
</entry>
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            <strain evidence="1">IBT 30728</strain>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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        <source>
            <strain evidence="1">IBT 30728</strain>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
            <dbReference type="EMBL" id="KAJ5494996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="71" mass="7464" checksum="A656A1BFF89B2389" modified="2023-11-08" version="1">MDSVYSGTEGIRPGGGRGPAAAVVVDPAEAVFPFRKVSKAGILTSSFMCRMFGLFTHQLIPESTVAGYRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
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    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="277"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="308" mass="35201" checksum="051D96630C966FBE" modified="2023-11-08" version="1">MSDHTGRPTGDGLVLEAWGQGLMIGSLLIMAAVTLANMKKHILLHKLILAELLLAMGHGTFIFLHEPKYGWYLSVTAVGLNISWALHNVIAWMKNRPFLSRRVSMIYIITVVLSWPYWIVEIYANFTYFNNINNIFHTTRPLEPIFRDPWWVFTTISLFWTIKREYGFGLSELVVISPRFGIMLASMCLSIAFIVVDTCSVLDVFSNSLPQGIEPFWKLSFIFKCLCDTVILDDFKTALDRLRAYWLRKQASGHVLLATPRAARSARRNAEEIEDIESASGDMSSHQSGREHTKSYSIPRVVLRDDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2X4</accession>
    <name>A0A9X0C2X4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795070.1">
        <property type="nucleotide sequence ID" value="XM_056930777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2X4"/>
    <dbReference type="GeneID" id="81621026"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5496057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="75" mass="8251" checksum="6620BC5628777F58" modified="2023-11-08" version="1">MTPCACHADQADVPLTERGRGSPATFTEHAPERGTGAYADADADKIGIDQVAQKDEQGKTRHEEDSQLMVKRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKG1</accession>
    <name>A0A9W9WKG1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="16">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">N7539_009398</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="16">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="16"/>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785715.1">
        <property type="nucleotide sequence ID" value="XM_056938993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKG1"/>
    <dbReference type="GeneID" id="81629243"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000004">
        <property type="entry name" value="Acyl-CoA desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="4 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="330"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ5466669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="455" mass="52128" checksum="905409A87F476333" modified="2023-11-08" version="1">MSAKTESARPRATETKKVHIADTAMTRQNWYKHVNWLNVFLIIGIPAYGCIQSLWVPLQLKTAAWAVIYYFFTGLGITAGYHRLWAHCSYSATLPLRIWLALVGGGAVEGSIRWWARGHRAHHRYTDTEKDPYSVRKGFWYSHLGWMVMKQNPKRIGRTDISDLNEDPVVIWQHRHYLKVVFGMGLIVPMLVAGLGWGDWFGGFVYAGILRIFFVQQATFCVNSLAHWLGDQPFDDRNSPRDHVITALVTLGEGYHNFHHEFPSDYRNAIEWHQYDPTKWTIWMWKQLGLAYDLKQFRANEIEKGRVQQLQKKIDQKRARLDWGTPLDQLPVMEWDEYVEQAKNGRGLIAIAGVVHDVTDFIKDHPGGKAMINSGIGKDATAMFNGGIYYHSNAAHNLLSTMRVGVIRGGCEVEIWKRSHKENSEYVRDEMGQRVIRAGQQVTKIPEPIPTADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKT6</accession>
    <name>A0A9W9WKT6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785846.1">
        <property type="nucleotide sequence ID" value="XM_056938469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKT6"/>
    <dbReference type="GeneID" id="81628719"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5469256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="122" mass="13261" checksum="500B9F1F880B07CF" modified="2023-11-08" version="1">MLRRSHRPTTTTTRETKPSLMTRLKGPGARTQTTKTKTTTTRHGHGHGHATTTGSGHRTSKRHVGTTQTAHHHKRKVTMGDKVSGAMTKLKGTLTGRPGVKAAGTRRMHGTDGRGSHHRTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKU7</accession>
    <name>A0A9W9WKU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785955.1">
        <property type="nucleotide sequence ID" value="XM_056938578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKU7"/>
    <dbReference type="GeneID" id="81628828"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF32">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5469365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="249" mass="26547" checksum="04CCC4C329AB1903" modified="2023-11-08" version="1">MSDSTIVLITGANSGVGYATTEAIVSQPGFHVILACRDPAKGNQARAELLQKHPKGSLSVLQLDVEDDNSIAQAVTSVTNEFGRVDAFISNAGTTAVGTSGREKLQRTFSANVFGAMMVTEAFIPLLLQSKQPRLVQISSGLGSLGLASDLSSPYAASPWDEYRMSKAALNMMTIQMHKRLMGKNVRVFAFCPGLVRSRLRGESEEEVSAQGRAGDPMVPGRALLDIVAGRRDEEAGQFLSAASGVFPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLH6</accession>
    <name>A0A9W9WLH6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_009266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786238.1">
        <property type="nucleotide sequence ID" value="XM_056938861.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81629111"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054833">
        <property type="entry name" value="FormamaseFmdA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045496">
        <property type="entry name" value="FormamaseFmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891:SF1">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141130">
        <property type="entry name" value="Acetamidase/Formamidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5469648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="412" mass="45024" checksum="58B840691B64E74C" modified="2023-11-08" version="1">MGVKEIRTALKVDLNKHARDQPGLHNRWHPDIPACGKIANGEVVKIECLDWTGGQIKNDDSAEDVRTVDLTEIHYLSGPFDVETAEPGDVLVVEIQDVQPFQDQPWGFTGVFAKENGGGFLDEIYPKAAKAIWDFEGIFCSSRHIPGVRFAGLIHPGILGCAPSAEVLAEWNRREGELIAANTVEDRIVAQPPQPHNAHAGNATEDVKEKVAKEGARTIPGRPEHGGNCDIKNLSRGSKVYLPVHVPGAKFSVGDLHFSQGDGEISFCGAIEMAGVITLKFSVIKNGMAKMGMKSPIFLPGPVEPQFGPGRYLTFEGFSVDENGKQHYLDATVAYRQTCLRVIEYLRRYGYSDYQIYLLLSCAPIQGHIAGIVDIPNACTTLGVPIDIFDFDIRPEAEVVKRDLGSCAFASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQS9</accession>
    <name>A0A9W9WQS9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
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                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786521.1">
        <property type="nucleotide sequence ID" value="XM_056938139.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81628389"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="158" mass="18368" checksum="330CC4FAAE76AC75" modified="2023-11-08" version="1">MDAPAKVALGSRPCKRRREDPEVDDSKLADERQTPKEKMSTLTRIKAAPRGMKLSLVEEMKPLLDENPPFASSTMEFLDLYLLLWESYVIDSARKIRLEEEQRRLQAENAWLIHANNRLFQACTDRELILWDRQEAFDSVQEAMVQVLEALRVPLISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WR40</accession>
    <name>A0A9W9WR40_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">N7539_008709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
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    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786686.1">
        <property type="nucleotide sequence ID" value="XM_056938304.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81628554"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="KAJ5472140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="81" mass="9615" checksum="76C414237926AE66" modified="2023-11-08" version="1">MEKIQDCVPRLKGDFNFDIWMTEFERFLNYKDLDYWPVITGFYHPPIDTPLDLPRQSEVRNILADKQGVDPQNITDAEVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WR93</accession>
    <name>A0A9W9WR93_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">N7539_008755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Petersen C."/>
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        </citation>
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            <strain evidence="1">IBT 30728</strain>
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    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5471812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5471812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="86" mass="9685" checksum="4DAE58C4B3A29E96" modified="2023-11-08" version="1">MTFPKIFKVTSEQWRRLSEDKKSEWHALANVKRESAMGKITLHIAIDPDDVAVIDPRTTWPQGLATIRPDDQDVTVAVDVSSTPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU39</accession>
    <name>A0A9W9WU39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
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                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475298.1"/>
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    </dbReference>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="468" mass="51340" checksum="CCB7A4F17247C32D" modified="2023-11-08" version="1">MRIKSAWLDAAGIARCSPVNVAEKSKVACDHSVPCVSTRNHRECSTCSSTQGFVASSLPNKDISSPSNEHFSSADGGDAVHTTQMALGTTPRASLPLPDRAESAPPLFDYPRVRSEKQGFFGFTSHMSIMTEDLTQLGITSTGLDQATSVHEKPIPYEKVASGCQVLSFLQNRPMIDRAIGLLFKSLDCIHLHCGELIVRPWLSQLWISSATGDHIRWGVIAMVANYVGSFAMVRSSSDPFFEEFDMDRKSLLDQMTEVSGFCIGFCRESGLLDDGFLYALFEYYSIIKHTKGGASYASWCVGAELNSAFRVMGLHQEIRADAQVPLFLAELQALGPSQSTGLGDCEDGAKCLKRARQKEYEKEEQDSRAQTPCNDETSSSSLCHKHRVTAMTGIPIDQDSAPVNVGELVGLRISDQLQGSREMPSFLTYNIQCTHELEWDMVLQVGGESLKVKSEQPVLVMERSVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU45</accession>
    <name>A0A9W9WU45_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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        </lineage>
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    <reference evidence="2" key="1">
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                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787288.1">
        <property type="nucleotide sequence ID" value="XM_056937423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WU45"/>
    <dbReference type="GeneID" id="81627672"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018809">
        <property type="entry name" value="DUF2406"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10295">
        <property type="entry name" value="DUF2406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="346" mass="37790" checksum="876942231EF2DC07" modified="2023-11-08" version="1">MAGPEQQTRNRGFSVKSDKSHKSNTSGHKSHLSESSQEKARRSLQTKADPTVAMNELQPMAVALEKSNMGSLRAIEHKDQFGNPITEPDWSNPTRPRYERPLDTIRSFEAAIYGTYVNNRPGSYIRTDDAASQMGDYTSRRTSYHGGQNGGYSSRGYNDQNAYYGRNAQSRPDSLIDGYGNSSQAPDNYYPYNHQNGNGRRPRHMSRMSTDQSGYGNGSGNNFSGQYAYQQQNYDRSHDNAAGMSGSGSGYTDSHGQSTDPSSLNSSLDQLQQQQQRADERGSPGYGPPGYGGGSQMSGTGRGASAVPGWGPSAAGTPSRGPPPLPKPQMHDDKKKGWFKKRFSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUC7</accession>
    <name>A0A9W9WUC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787418.1">
        <property type="nucleotide sequence ID" value="XM_056937553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUC7"/>
    <dbReference type="GeneID" id="81627802"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="798" mass="92944" checksum="A08ED6F1E09AF1A9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUQ2</accession>
    <name>A0A9W9WUQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787396.1">
        <property type="nucleotide sequence ID" value="XM_056937531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUQ2"/>
    <dbReference type="GeneID" id="81627780"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
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        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="378" mass="42681" checksum="63E36614CCD6B1E0" modified="2023-11-08" version="1">MNWTGGQLHRHLTRPGNLSQAQKQHFFQSRQQSSGNIRLDQDRLKIGQDIDDSQPGDTVTHDLHDPERGGTEEVINGKSSLPTRSTDPPFTERHDHLERLKRRLLEDTDWAVVSAARPLQIKFTVDREIDRFGKRRRLNDTDRQRMLDANTGQGHSTLFTTTGRPSRARAKSPDPIRIRITKPPFDPNTQLGDGNRRKVNDVGARRCPDTWDTSESNSPARARNKRYSSADQNMHRSAGSTTQLNPSLPSPLQDSMILWAKPRYSKSRQPHRALSDVSCAPTEILPVSSTLMPSDSLSSVNVQSWLPHPVRRKSFSGHVAMHASDLESSSHFPPCFEPHYTPDFQFPELAQVQPSVPVEIFGQLVRNRSISISDTSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUV0</accession>
    <name>A0A9W9WUV0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787648.1">
        <property type="nucleotide sequence ID" value="XM_056936849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUV0"/>
    <dbReference type="GeneID" id="81627098"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF2">
        <property type="entry name" value="CRAL_TRIO DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G13930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="201"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="472" mass="53854" checksum="EA42EE851E90FDAF" modified="2023-11-08" version="1">MTTPATAPGYVGNLDSTQEKRLQELWITLMQTWDREISALDCDRPSETSPKVNGKQGRRMFSLSKSPAQPTETELAAIPPNLLSTLESLGAGPGELKAVGSLLMKVPGDKLRSAFLTLLRQDHPDAFLLRFLRAERWNVPKAWIKFVGSLYWRAFEYKVDEQVLSRGEEYNLLKSQEEANTSSKRDGEGFMHQLRIGKGYLHGCDRAGRPICFVRVRTHAADPQMQKGLFDYIMQGIETARFLQVPPVESMDYSLKAILFDLTGFGLSNWDFPPVRFIIETFQNYYPESLGAMIFYNAPWIFSGFWKIISGILDPVVASKVHFISGPKELEKLVPRSQILKEFGGDEDWEFKYIEPLPNENERLKDTVTRDLLLSERRQLGDELFCLTNQWISQSDVKTTLERRDEVISGLRVNYWKLDPYVRARNYLDRTSVIKEDGTIDFYPHRISGSVDEKSSGAKESVEEQLTAATIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUY4</accession>
    <name>A0A9W9WUY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Increased loss of mitochondrial DNA protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787757.1">
        <property type="nucleotide sequence ID" value="XM_056936958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUY4"/>
    <dbReference type="GeneID" id="81627207"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018815">
        <property type="entry name" value="Incr_loss_mito_DNA_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28029">
        <property type="entry name" value="PROTEIN ILM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28029:SF1">
        <property type="entry name" value="PROTEIN ILM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10311">
        <property type="entry name" value="Ilm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23933" checksum="482862E46A749AD8" modified="2023-11-08" version="1">MPLLSSKTLIQAHAVFLVVIAGYLLKNPATITDSDIVFMMGEALRIDFPPSTNPTTSPYVICSILLFTAAAVDLVLLTSLPFHEALNDALPYIRPLRNSNLPAEDLQALARLPEYITKSLTMYWNIWIAVSAVRFALYGALSFYIYQARGNLVDSTYASKAAPTGLAQLKTRVVFTFAFMEMMVWFWVFFTCREERQQRLSKMLEDAREEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV22</accession>
    <name>A0A9W9WV22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial distribution and morphology protein 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_007399</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM31/MDM32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787799.1">
        <property type="nucleotide sequence ID" value="XM_056937000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV22"/>
    <dbReference type="GeneID" id="81627249"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF0">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="107"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="107"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5477255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="698" mass="78209" checksum="6787365B7BA51FAE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV34</accession>
    <name>A0A9W9WV34_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787832.1">
        <property type="nucleotide sequence ID" value="XM_056937033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV34"/>
    <dbReference type="GeneID" id="81627282"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="160"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5477288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="268" mass="29163" checksum="3759FE3724309901" modified="2023-11-08" version="1">MAQGSESSAVLETARLRLEPIDLAHLEGFHRIWSDPNTTQWSPWRLLGSPNGFSTLPIQYPTTRLHLPTYTLPHCSSKGVSPSLEETKLRISRILPDPTQPGIVNYGVFIRQPQPSLQTTPVPTPSPSPIPTANANSTTTLSSSSSSSSSSSSSSSPVFGIVGIHKDDPVPEIGYLFHPSVWGRGYATEAVSAVVSRYFHLRPEAACIEARVDSTNGPSIRVLRKCGFEEIETLVGGAVAAWMEPQVRDLVVLRVGRERKAVDERVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV46</accession>
    <name>A0A9W9WV46_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_007206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787606.1">
        <property type="nucleotide sequence ID" value="XM_056936807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV46"/>
    <dbReference type="GeneID" id="81627056"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3250:FF:000001">
        <property type="entry name" value="60S ribosomal protein L13a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5477062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="202" mass="22952" checksum="F4274DDC37E6B678" modified="2023-11-08" version="1">MSSFEPVVVIDGKGHLLGRLASTVAKQLLNGQKIVVVRCEALNISGEFFRAKLKYHAYLRKMTRFNPTRGGPFHFRAPSRIFYKAVRGMIPHKTARGAAALERLKVFEGVPPPYDKKKRVVVPQALRVLRLRPGRKYCTVGRLSHEVGWKYQDVVSRLEERRKVKSKAYYERKKAARRNLAKAESGANVDSNTKSQLAQLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV61</accession>
    <name>A0A9W9WV61_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 NT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787883.1">
        <property type="nucleotide sequence ID" value="XM_056937084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV61"/>
    <dbReference type="GeneID" id="81627333"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5477339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="349" mass="39580" checksum="4BD59F055FD86AB0" modified="2023-11-08" version="1">MQAFVPKNRRPRFELVLRIIDINNVPLRNSAVWIRWRLPSSSATEHQGHTEKASLLDHRASWNYEKTLNVRLTIDRNLMLQECDINFEIIQEFHGSPVNEKHILGKIKLNLAEYVDKVDEDEGVIRRYLMSDCKINSTVKIGIAMRQVEGDRNFTTPPLKSATVFGGIARVVHMSEPGDSEELVHVPAIATRSREAADMQDMYRRTLAASWNSRAWDLPADKLVEELFAGNSCWNNTSHDHPNDGFSDSLSESLTVEAARQQSRSGNRLSPSYEKQPKSASSGSNSTARLASTSNSGHSHPQKGGSLEQQLHENAKGRGWKSRQAEHELSEFDVREDLRSWEIRAERQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1T6</accession>
    <name>A0A9W9X1T6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788238.1">
        <property type="nucleotide sequence ID" value="XM_056936303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1T6"/>
    <dbReference type="GeneID" id="81626552"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5480808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="448" mass="49629" checksum="F76D3408884337DD" modified="2023-11-08" version="1">MASSTMRMQALTSVYENGHGVNGLGGALHSNASVPHFKSDGTFTLLPPFVSPKQRAGDLTGEPFELLPTHVPPSASYMSSACFTFGTSTTAVASPESWSDRLDFHAPLSTPDAHGIHPLFPETKEHPQVYSIDLLAFDSISLTILSSLFFQTMPPIVADDSPRGQPCTQTGATLMTLGHFKTSLQQKFIYSDYVKSLRDIRAEPCSDIAPNGWLIEEESLVIGVDPSYVVPTGDDQPSDELDLQEGKLFVVEQIFSDMWALCSEISTSRPHHGRTPGPPNKLAGFGFVPLCAVTLAANYGTFLKRCREYQQHPDETILTPANGGRVLPPVRVQSVHVSREMDYWSLKGRQYFKTTKVHAVCQKFRPIGKNDDEWEPRDPFDHIQGKSSCLRRVWRKLKAEKLNANASWAERDSGPRQGVPNKKTLKGLRRDLNVKAGIRDLCGWIRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2D0</accession>
    <name>A0A9W9X2D0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_007003</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788539.1">
        <property type="nucleotide sequence ID" value="XM_056936604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2D0"/>
    <dbReference type="GeneID" id="81626853"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="41"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5481109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="375" mass="42602" checksum="D3136DC22093C613" modified="2023-11-08" version="1">MDYGSIPSQKLGDAIPENVFLIEMQGVSWALNGTAFALVVFRLYAQLVSFRRLFIDDILVILAWIILLTATSVWQVNGRYLYKFDRVISGLDPITPSFLSNWHRFMRSLAPLQILFYTALWCVKFSFLAFFYRLSCKVKWLRIWWVMVVVFTFGVYITSIADIEYKCSFESLEYILEQCPQLNHVHYENRTFWANCAGDVATDMMILSIPIMVLWNTKISRRKKIILLSIFSATILIMIIAIIRVAVKASLNHQTDVAWLCFWSIVEGTTAILISCVASMRQLFINAQAKGSREWSSNPLSTGQGVKSPHKMTGLVSSITNPNAPSSPESDIPLSPMSMVHVRHDYEVTRAAANARGPEDYAKRNTGTWKIPQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X378</accession>
    <name>A0A9W9X378_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Golgi apparatus membrane protein TVP23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_006256</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Golgi apparatus membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TVP23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788782.1">
        <property type="nucleotide sequence ID" value="XM_056935858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X378"/>
    <dbReference type="GeneID" id="81626107"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF7">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5482810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="188" mass="21028" checksum="E65CCB3FADADE159" modified="2023-11-08" version="1">MEQANTGDLNWRLSAHPITLLVFLGIRIGALLMYLFGVLFIRNFVLVFILTLLLLSADFYYLKNIAGRRLVGLRWWNEVDSASGDSHMVFESSDPNVRTISATDKRFFWLSLYLTPALWVGLAILAIVRLVGVIWLSLVGIALILTITNTVAFSRCDKFSQASTFANRALGGRMVNNLAGSLLGRLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X392</accession>
    <name>A0A9W9X392_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_006477</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789003.1">
        <property type="nucleotide sequence ID" value="XM_056936079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X392"/>
    <dbReference type="GeneID" id="81626328"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF4">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="6"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5483031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="378" mass="40670" checksum="B0D6C9766B42F83D" modified="2023-11-08" version="1">MTQTHSILVLPGDGIGPEVMAEAIKVLRAFENPECKFVLREELIGGCSIDATGKPVTDEVKQAALTSDAVLFAAVGGPKWDKARRGLDGPEGGLLQLRKAMDIYANLRPCSSHSPSSSITKEFSPFRHEVLFGPEKDATGLDGVDFVVVRENCGGAYFGKKVEDADYAMDEWGYSTAEVQRVTRVAAQVALRHTPTWPVISLDKANVLASSRLWRRVVEETMATEYPQLKLIHQLADSASLILATNPRALNGVILADNTFGDMISDQAGSIVGTLGVLPSASLNGLPGDKTLQTRPYGLYEPTHGSAPTIAGKNVANPVAMILCVALMFRYSLNMENEAQQVEDAVRRVLDKGLRTPDLGGNLGTKELGDAIVAELRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3J3</accession>
    <name>A0A9W9X3J3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Kinesin-like protein bimC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_007035</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5481141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_056936636.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81626885"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:microtubule binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:microtubule-based movement"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinesin-like protein bimC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KIF11-like"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Kinesin-assoc_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13931">
        <property type="entry name" value="Microtub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="17">
        <location>
            <begin position="80"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="529"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1050"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1121"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="761"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="960"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="529"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1133"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="186"/>
            <end position="193"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023175"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5481141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1208" mass="134859" checksum="858010D33ABDB428" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3J8</accession>
    <name>A0A9W9X3J8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="47"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5482895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="65446" checksum="B9C6E3FBDD13F504" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X576</accession>
    <name>A0A9W9X576_9EURO</name>
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        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_006045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
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    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000007">
        <property type="protein sequence ID" value="KAJ5483845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789115.1">
        <property type="nucleotide sequence ID" value="XM_056935647.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A9W9X576"/>
    <dbReference type="GeneID" id="81625896"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF35">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5483845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="52478" checksum="1E0ED8778D4EEFE3" modified="2023-11-08" version="1">MGESQEQSVPWGYRWRSSGRFILIATATSVLTDMYRHQFVVSILPSILEDRLDLEPEILQRVSVALLAQTALISFLVTPLIGRLANCLGARTWLQLGLLGQLLGSLVVASSHSVIGLFGGRAVQALANTIVGVQGVKTLSSVGSSNRHEKTQRYLSLAVAAGSSGGPLVAGTLFEISDYWVAWKTASAASSLGIILQSLMLVPSEDLPREPEVSDVPRYPEEGPDERSSLLSSSFESTKTIKTHLPADVESVKRDLNLYLHLLTSRRYMGGIMISVCFTIVSVSFDTTMPLHVGEAFGWGSQLTGILFAVLHGPHVFLSVPTHWLKNRVGSHHTASVGFLGLGVLLWLAGTPGSEQGSWAASGDRPAVIYASAVAAAGVFMSLLQGAGLTETACKSHPRCDKSRGAVQELETQQTRAFDQEAVAHAMVISSLSVKLGLFLGPIISGRLVENGGYYEMSCVLGEFESSRGCQHPDLQTALKRFWMWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5H9</accession>
    <name>A0A9W9X5H9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_004791</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789587.1">
        <property type="nucleotide sequence ID" value="XM_056934393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5H9"/>
    <dbReference type="GeneID" id="81624642"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF7">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="804"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="392"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="470"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="435"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5484803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1146" mass="124954" checksum="A6999040F3182060" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5V2</accession>
    <name>A0A9W9X5V2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789596.1">
        <property type="nucleotide sequence ID" value="XM_056934402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5V2"/>
    <dbReference type="GeneID" id="81624651"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5484812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="80" mass="8118" checksum="64E8AE5D22D289C7" modified="2023-11-08" version="1">MSYTEHIQTTCQTASGKCPSSVNTATCATQCGVEPDSARVGMSGSSPTLSGLVIRPPDPTASMPEAEAKNMVSQSLKGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6E1</accession>
    <name>A0A9W9X6E1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_004964</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789760.1">
        <property type="nucleotide sequence ID" value="XM_056934566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6E1"/>
    <dbReference type="GeneID" id="81624815"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="10">
        <location>
            <begin position="260"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="640"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="640"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5484976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="890" mass="96776" checksum="01723F7B93DFA20A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X767</accession>
    <name>A0A9W9X767_9EURO</name>
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        <submittedName>
            <fullName evidence="1">Isoflavone reductase family protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">N7539_005591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056935193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X767"/>
    <dbReference type="GeneID" id="81625442"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5485603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="98" mass="10984" checksum="9B7DDAE0441018A0" modified="2023-11-08" version="1">MARPWAKSAALLLGAPPCKDDKTLATLYVEANKNYSTNNMTWLALYVRHDSSLGYVEYSGYISTGELYPDFKPTTFRGFLAGVLAGKEKEVYSMWVMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XC53</accession>
    <name>A0A9W9XC53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790693.1">
        <property type="nucleotide sequence ID" value="XM_056933152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XC53"/>
    <dbReference type="GeneID" id="81623401"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5488660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="74" mass="8673" checksum="79D3ADECD9CC3793" modified="2023-11-08" version="1">METLPQVRLRVLTHGVRYATSSAFKVEVPREQRKQSLLNELRYHKRRPSVALICLQEVLHQQRVDILKGLNEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCI0</accession>
    <name>A0A9W9XCI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790571.1">
        <property type="nucleotide sequence ID" value="XM_056933030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCI0"/>
    <dbReference type="GeneID" id="81623279"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF26">
        <property type="entry name" value="FMN REDUCTASE LOT6, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040981890" description="Amine oxidase domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="53036" checksum="74143826A545D120" modified="2023-11-08" version="1">MFSISRFCLLWQICSATVTLPHSAKHQAAAAHAIVRDVAIIGGGATGTYAAIRLQEDFNKSVVVIEKERDLGGHTNTYHDPISKTTVELGVVAFHDLPVVTKFFARFDIPLVKFFFNYTLKNVNFRNGHPVGELESHKSTLGMFADYSEQLQRFKSLEEGYVFPASVPEDLVRPFEHFARIHNLTALIPRIWTIDQGVGDLLQLPTLYVLKSFGPEMLRSLSSGFWTTKRRNNHELYERAFQRLKTTNSVHVNSVVESMNRDIPGRYGKMVVSTPFGRKVVRAKQFLFTIPPTLETLTGFDLDRYEKNLFSAFQYMDYSTGLIRGAPIPRGTTMCNKIPDPHVYFLPRLPTVYTLGPTHQPSFLTDVKFGSNTSSMTEQQVRERIISDSSRALPGNPDLELVAYASHKPYELRVSSDLIRDGFYQELNGLQGLRRSYWTGAAWHAHDSGLLWNFTEGILSRMQRDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCK1</accession>
    <name>A0A9W9XCK1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_003794</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790937.1">
        <property type="nucleotide sequence ID" value="XM_056933396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCK1"/>
    <dbReference type="GeneID" id="81623645"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF127">
        <property type="entry name" value="HISTIDINE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040891869" description="Phosphoglycerate mutase-like protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5488904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="62907" checksum="4C9F992D8324FFB8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCM4</accession>
    <name>A0A9W9XCM4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790872.1">
        <property type="nucleotide sequence ID" value="XM_056933331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCM4"/>
    <dbReference type="GeneID" id="81623580"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="193" mass="19924" checksum="BAC74A0DB3E05221" modified="2023-11-08" version="1">MATKKNLRAPSAPPAPASRAEAHTKKTAGACAACRKSKKRCRHRPSPSPAPSSSAVPAGPASSSAVLSGSALGTTQGRRAKSTRVRSASVAAAGPSGERPSKRARPLERPAPTSTDPVVEAATLSVNVVFAKELAKRLAEFEASFEASMAAHKAVMEAGRAVRETVKSWKGTWSAASVLPVAEEATEERNGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCV1</accession>
    <name>A0A9W9XCV1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_003940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a key role in the late stages of endoplasmic reticulum to Golgi traffic.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791083.1">
        <property type="nucleotide sequence ID" value="XM_056933542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCV1"/>
    <dbReference type="GeneID" id="81623791"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000007">
        <property type="entry name" value="Trafficking protein particle complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5489050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="255" mass="28262" checksum="D17E31B94AF20ABA" modified="2023-11-08" version="1">MAAPPRHSAMLSMNSAVATPQPMPGDMSQGPPQSLTPQPSQGLRVPSNRKTIYDRHLNRSRNAELSRASFAYLFAEMVTYAQRRVTGIQDLEKRLNEQGYPLGLRLLDLLFYRTTTTSSSALSSSSTSSSPPNRPLRILTLLHLIHGPLWRLLFGRSADALEHSVSPDTPNEYMITDNDPLVNTYISVPREMNQLNCAAFVAGIIEGVCDGCGFEAKVSAHNQPTEMWPSRTVFLLSFGESVMEREKVLERSGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCZ5</accession>
    <name>A0A9W9XCZ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003357</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790500.1">
        <property type="nucleotide sequence ID" value="XM_056932959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCZ5"/>
    <dbReference type="GeneID" id="81623208"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042448">
        <property type="entry name" value="CCNB1IP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14305">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14305:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="130"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5488467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="325" mass="36390" checksum="F87D4189B34B68E2" modified="2023-11-08" version="1">MDFRLRCNSLKCRAQLQEKAVVTTCSHIFCLDCAGRLGLSRPTTNDRRCPACQTVLCNPDDAVSTVLNPTEDYKTSVLSGLDPTTIMECAGRALGFWAYQSTQEIFYQEYLGKSLTDKYTTLSTQMDKVIHNANSEISTLHEKVSEMQAQHEQVQKRNQELVDLYREKSKKLDQMTNLYNLLKARTMKSRMETAALENVSETLNSMSHWNAHVMPPPPSARSVPNASKSHTSKTPSYPFSPEGVEQLHRNQRSGTGSSRFSRPQKTAKSGVPTPVGHSVFNVRTAPVNKSTQPHRTRLPHSNRPSAAASHLPSEEEILARFGQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDB0</accession>
    <name>A0A9W9XDB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase lambda</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_004169</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791312.1">
        <property type="nucleotide sequence ID" value="XM_056933771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDB0"/>
    <dbReference type="GeneID" id="81624020"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000005">
        <property type="entry name" value="DNA polymerase POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019843">
        <property type="entry name" value="DNA_pol-X_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF28">
        <property type="entry name" value="DNA POLYMERASE LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00522">
        <property type="entry name" value="DNA_POLYMERASE_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="17">
        <location>
            <begin position="138"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="237"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity" evidence="15">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR622312-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5489279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="716" mass="79992" checksum="2FF9BFCC1064A8B7" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDF4</accession>
    <name>A0A9W9XDF4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791214.1">
        <property type="nucleotide sequence ID" value="XM_056933673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDF4"/>
    <dbReference type="GeneID" id="81623922"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="96"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="230" mass="25931" checksum="F0E7DAFF5A784CB4" modified="2023-11-08" version="1">MSRQDKHCTKVDFTGYQELPANSPSREAPSSKQTPPPHVPSQLNRSPNSKKRDASSPQSESARKVVRGGPKSLGLPQVCEDGTSRRLIVRDESPWDTYRRRLRCTLAGNVFIAAHRSRPFQAVAIREYTKRDVAKMRRLYDILDHDNVLTARECFVNEGCMYALVNDLPLTLEQLVGCRSLYPTETELASMVWQILSGLCYLNDTGLEHQSLTCRNILLGLDGVTKIGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDG8</accession>
    <name>A0A9W9XDG8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Aprataxin-like protein</fullName>
            <ecNumber evidence="4">3.6.1.71</ecNumber>
            <ecNumber evidence="3">3.6.1.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Hit family protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">N7539_003612</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O = a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:52140"/>
            <dbReference type="Rhea" id="RHEA-COMP:13186"/>
            <dbReference type="Rhea" id="RHEA-COMP:13187"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:136419"/>
            <dbReference type="ChEBI" id="CHEBI:136420"/>
            <dbReference type="EC" id="3.6.1.72"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end adenosine-5'-diphospho-5'-2'-deoxyribonucleoside-DNA + H2O = a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:52128"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:13181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:136413"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA + H2O = a 5'-end 5'-phospho-ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:52132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13182"/>
            <dbReference type="Rhea" id="RHEA-COMP:13183"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136414"/>
            <dbReference type="ChEBI" id="CHEBI:136415"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.71"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.71" evidence="4"/>
    <dbReference type="EC" id="3.6.1.72" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790755.1">
        <property type="nucleotide sequence ID" value="XM_056933214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDG8"/>
    <dbReference type="GeneID" id="81623463"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033699">
        <property type="term" value="F:DNA 5'-adenosine monophosphate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120108">
        <property type="term" value="F:DNA-3'-diphospho-5'-guanosine diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990165">
        <property type="term" value="F:single-strand break-containing DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000017">
        <property type="entry name" value="Aprataxin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032566">
        <property type="entry name" value="Znf-C2HE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF4">
        <property type="entry name" value="APRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16278">
        <property type="entry name" value="zf-C2HE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aprataxin C2HE/C2H2/C2HC zinc finger" evidence="20">
        <location>
            <begin position="218"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00068941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00076243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ5488722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="278" mass="31693" checksum="11CE0D7166C1F21E" modified="2023-11-08" version="1">MSEMTETSSSNHDSTATCSREQQTSAKRNAFTELLSSRQKQLKQTSGSLSSGSVPHGRSGGRDGLGAYISKPETFPPSVVVYYNDDFVTIHDMFPKSSLHLLLLPRDPTKTRLHPFEAFEDPEFLAKVKAEVQKLRHLAASELRRLYGKDSAQEQARQAALTAESPPDDLPPGREWEQEIMCGVHAVPSMSHLHVHVISVDRYSERLKHRKHYNSFATPFFVPIGDFPLKPEDVRRHPTREGYLKRDFVCWRCGRGFGNRFAELKTHLEEEFIEWKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDH8</accession>
    <name>A0A9W9XDH8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_004177</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791320.1">
        <property type="nucleotide sequence ID" value="XM_056933779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDH8"/>
    <dbReference type="GeneID" id="81624028"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF461">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="110"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5489287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="583" mass="64719" checksum="A9C7BD7A31AAA4DE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDR0</accession>
    <name>A0A9W9XDR0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791489.1">
        <property type="nucleotide sequence ID" value="XM_056933948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDR0"/>
    <dbReference type="GeneID" id="81624197"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF19">
        <property type="entry name" value="MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="198"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="376" mass="42206" checksum="2CA4868DC8FFBC77" modified="2023-11-08" version="1">MLDRATLTSTPVILASGVILLLPLLLIPQFNGWTKHLRIQLPGRRRQRSEIVSLRVYPIKSCRGFEVQSTTLKEQGLDLDRRWMLVDASTHEFLTIRQIPQMTRIRTALSSDGNELIMTVPFSHDGSEHATDTEPDRSGAARTIRIPSHPTREWLEANTQTSNVEIWGTKTDGYIYRDDINKPFSAFLGRPVALAYKGPQPRVLQGNGDPQLLGRTQSTAFPDVCPVLIASEASLAELNGRLQSQEFDPITIERFRPNIIVRGETPWIEDSWKTVRIHRGSASSAPNGPPPHEPLDVDVVARCARCQVPNVDPDTAVKHKKQPWDTLMSYRRVDEGIKFKPCFGMLAAPRNEGLVGVGMVLEVLEETDKHRYHAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDS2</accession>
    <name>A0A9W9XDS2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791457.1">
        <property type="nucleotide sequence ID" value="XM_056933916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDS2"/>
    <dbReference type="GeneID" id="81624165"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521:SF0">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="435" mass="47739" checksum="1E6F576A365DC1D2" modified="2023-11-08" version="1">MPYPSPPAQPPSPAAPKISGHENAPINVPSTTPSSLPSPLPIPIPFTTTTLHPKHITRSTFHHLLTCYPTTVRNVHRNKALLKLWPKKIQAQAQARSRGKAEKIVPVWGKIPVEIESGQLGDEERESVRAAVDAFLELDGWRYAGVSRAEMFGKEELVRTMEWKLKHGVNRPVLMSMVKSNTDETVRKSVSAALAALSTGENPLSKPDEAFPNDSLDAFGPVRGVGVATASLILSLLTATSPEKEDGNGQQTATVKQEVPFFSDDVYLWLCLEDFPEPTSGDEQDGQGTETKHGNLPEFNRPNVSVLNVKYNLAEYGQLWESCWAVHERLNRAAEEGKPAGMGPDRTEMAAISHLDIERAAFVVRNIAVSGFFGDGAGVEKIGLVESASETMVEPVQEKEEKKEKAETAGDPASRKKREVQDSHVRRYSKRTKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDV6</accession>
    <name>A0A9W9XDV6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NUC153 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_004374</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791517.1">
        <property type="nucleotide sequence ID" value="XM_056933976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDV6"/>
    <dbReference type="GeneID" id="81624225"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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        </source>
    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="688"/>
            <end position="707"/>
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        <location>
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            <end position="141"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5490950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="760" mass="84148" checksum="9672A56DC0E44D0A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFE5</accession>
    <name>A0A9W9XFE5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MAP kinase kinase kinase</fullName>
            <ecNumber evidence="11">2.7.11.-</ecNumber>
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    <gene>
        <name evidence="16" type="ORF">N7539_002729</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with by SSK1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="11"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792291.1">
        <property type="nucleotide sequence ID" value="XM_056932332.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81622581"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06626">
        <property type="entry name" value="STKc_MEKK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000482">
        <property type="entry name" value="MAP kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017240">
        <property type="entry name" value="MAPKKK_Ssk2/Ssk22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037579">
        <property type="entry name" value="MAPKKK_SSK22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="1029"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1326"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="756"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1332"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="1058"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5491162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1351" mass="152159" checksum="630C75BC40F2F465" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFF5</accession>
    <name>A0A9W9XFF5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine-rich transmembrane CYSTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792067.1">
        <property type="nucleotide sequence ID" value="XM_056932108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFF5"/>
    <dbReference type="GeneID" id="81622357"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5490938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13110" checksum="921881215C0030D4" modified="2023-11-08" version="1">MSYNKPTSPPPSYPAQTYNNEGFQSPAPHGASQDYYGGAQGGQGGYPPQQGYYPPQPQGQMYYPPQQGYPPQQGYPPQQGWPPQQQQGYYADNRGNGGGGSGAGGICAGIMAAFACCCCLDVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGI7</accession>
    <name>A0A9W9XGI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_003329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792890.1">
        <property type="nucleotide sequence ID" value="XM_056932931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGI7"/>
    <dbReference type="GeneID" id="81623180"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="298"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5491762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="472" mass="53130" checksum="3709D6F1446D71E3" modified="2023-11-08" version="1">MQALRRWSRLRERPAYVGFRTATFATVQSSHTQTNREVITRLLRLVDSEHQIREYLDEIQSTAGPPLAVIAIDPNALLPPSRFSSTGLQLERLIDSLVFLRRVGLFPVVVHGELIVRAPDTPELEYDRQSEPSRLIRRIRTTNLQISTLLEQRDVETRPLPCSVFAAVAEPDSRERNCQMSDPSMAIADLEIKSIRSAIRADCVPIIATLGISFADSRLHALNLMDTAISLTRELQPSRSILVHPDSPPVTSTGRLAASSVLTKEVSTGSNIVIKTAAELGQAVFNTASSHRSRQGSHSVESVSSFKDFPSEDALRRALERHPDPTVGNNLDHFLSRLEREDFTAYYDYDFTASFPEETIRNLAFVFPQNAFPWQTPSLILPDSNSNELHGKRSHHSGIEVTPELAVFAVSRADWRQGVADKFWQRIRADYGALWGSLEETDPSLSWWRARSTGSFRRRPDDKVFLWHGKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGK9</accession>
    <name>A0A9W9XGK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792537.1">
        <property type="nucleotide sequence ID" value="XM_056932578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGK9"/>
    <dbReference type="GeneID" id="81622827"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="758"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="945" mass="102522" checksum="A65F0243E49AFF71" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGV6</accession>
    <name>A0A9W9XGV6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RNA polymerase II subunit A C-terminal domain phosphatase SSU72</fullName>
            <shortName evidence="11">CTD phosphatase SSU72</shortName>
            <ecNumber evidence="11">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_001390</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Component of the cleavage and polyadenylation factor (CPF) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="11"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793024.1">
        <property type="nucleotide sequence ID" value="XM_056930993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGV6"/>
    <dbReference type="GeneID" id="81621242"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000039">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000189">
        <property type="entry name" value="SSU72p Phosphatase and transcription/RNA-processing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 11" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5492644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="295" mass="32558" checksum="08760C5F10B408EC" modified="2023-11-08" version="1">MASYDPRVNTNSTTQNPPPPPPPPESAPSDMTAPTDGAADVVAATTTPNNTNDEQTDSWKLKFCTVCASNNNRSMEAHLRLATAPSAFPVISFGTGSLVRLPGPSITQPNVYSFNTTSYNQMYEELEEKDARLYRHNGILNMLDRNRNLKWGPERFQDWIPGQPRLEHISKGDKGAQGTEGGVVDVIITCEERCWDAVVDDLMNKGNQLNRPVHVFNVDIKDNHEEALVGGRAILDLANRLNESAMAQRNTHGSAGWENGSGAARLSFDESVPEILAEWQEKHPNLPALWTLAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGY1</accession>
    <name>A0A9W9XGY1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.150</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Type III PIP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_001547</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH20</accession>
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        <recommendedName>
            <fullName evidence="5">LysM domain-containing protein</fullName>
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        <name type="scientific">Penicillium diatomitis</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
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        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <keyword evidence="2" id="KW-0843">Virulence</keyword>
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            <begin position="1"/>
            <end position="27"/>
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    <feature type="chain" id="PRO_5040984798" description="LysM domain-containing protein" evidence="4">
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            <end position="387"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5492749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="387" mass="40878" checksum="5A8B002AB7CAAC96" modified="2023-11-08" version="1">MVAFRRYSCGLLALWAFVLAFAAIASADSVFGHQKPQSADFAGSVDHNETLLYARGSTALCKVYVTQSGDNCDSIAKKNGISVAQLTSFNARSWRFNCAALPQGATICIGPGEPPMPTAKGDAVCGPLMPGSMRPDNWADLASINPCPKDKCCTVDGFCVSPSGNKCTSQDQACVSNCQLGAPKAPNPPPAAKPTVNIPVLPFAKPNPKERTTMTKFPITTAPGITTAPAITTAPGTTKNVPKPPSTTSKKSEVASVTSVNGPAWTLVAYTSTICDGEYYVIRGHADMDKKCIDLPGDYYTGADEVAGVYCKHFTDGGFRSGSCATGITRTIYSWNLRGGVCTASDSSCEDGGGRSFQIDAYDGGCQIDYSAEHVELKWRSIRCQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH28</accession>
    <name>A0A9W9XH28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_003215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792776.1">
        <property type="nucleotide sequence ID" value="XM_056932817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH28"/>
    <dbReference type="GeneID" id="81623066"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF7">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5491648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="355" mass="38904" checksum="33FF59A7F13DD97E" modified="2023-11-08" version="1">MNVKLPRLAESLVRDCSRQATNAPKLTRTLATTRHRASRLRARLEIPPPFPVTKSCPETTCNCPTTPALPEGLPIDHKQALNGTMAAYAQQLVVCTGQRDWTSRIEDDGKEQGWGALVRGLKQMMGRGGPYLDPFNNLLVTNSSLKPSVPSSTAASALLFPAFKYIPSIPTADLETFIRAFLLPTQLHEMHSSLPEAKQRDMIRVPDLESQFSKVMNIQQSPTILICGHGGRDMRCGIMAPVLEKEFQRVLSTAGFQFDGSSGVQDGPSHSNVGLISHIGGHKYAGNVIVYIPPKMTMGPETTGELHPLAGKGIWYGRIEPKHVQGIIEETVLRGRVVADHFRGGIDRNGDILRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH64</accession>
    <name>A0A9W9XH64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mucin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793189.1">
        <property type="nucleotide sequence ID" value="XM_056931158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH64"/>
    <dbReference type="GeneID" id="81621407"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="683" mass="72036" checksum="7812FD29570363E9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHA2</accession>
    <name>A0A9W9XHA2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_001707</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793341.1">
        <property type="nucleotide sequence ID" value="XM_056931310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHA2"/>
    <dbReference type="GeneID" id="81621559"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="121"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="339"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5492961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="520" mass="57345" checksum="879F62346FF03E64" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHB8</accession>
    <name>A0A9W9XHB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_001737</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793371.1">
        <property type="nucleotide sequence ID" value="XM_056931340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHB8"/>
    <dbReference type="GeneID" id="81621589"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF9">
        <property type="entry name" value="ACETAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="73"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="225"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5492991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="547" mass="60553" checksum="5EDD5AA0EACFFBAF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHI4</accession>
    <name>A0A9W9XHI4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_001859</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with histone H3 and histone H4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ASF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793493.1">
        <property type="nucleotide sequence ID" value="XM_056931462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHI4"/>
    <dbReference type="GeneID" id="81621711"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1490:FF:000001">
        <property type="entry name" value="Histone chaperone ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017282">
        <property type="entry name" value="Hist_deposition_Asf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037759">
        <property type="entry name" value="Histone_Asf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="156"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="216"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5493113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="277" mass="30736" checksum="586259ABF4E92EBC" modified="2023-11-08" version="1">MSVVSLLGVKILNNPAPFTASYQFEITFECLEQLQKDLEWKLTYVGSATSSEYDQELDSLLVGPIPVGVNKFIFEADAPDLQRIPSSEILGVTVILLTCSYDGREFVRVGYYVNNEYDSEELAAEPPAKPVIERIRRNVLAEKPRVTRFAIKWDSEESAPAEYPPDQPEADRLDDDSNTYGAEEAELEAALVKELEEANKQGEDQEMEGGEATAGNDDDDVSDAESEDLEEESDDDDDDLDDEEAGEGDEDVEMGDDAEQKDDSGKPHQAQPEVMVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHM7</accession>
    <name>A0A9W9XHM7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WD repeat-containing protein JIP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">WD repeat-containing protein jip5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_001275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792909.1">
        <property type="nucleotide sequence ID" value="XM_056930878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHM7"/>
    <dbReference type="GeneID" id="81621127"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF20">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="351"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5492529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="407" mass="43160" checksum="8A5A4C4D4A74628D" modified="2023-11-08" version="1">MLDTVCSLPLSSDLFSQAIHPNEPVVSVGLASGHVQTFRLPHDEIDSDDGASTSSSRNGKGHIDTMWRTRRHKGSCRCLGFSVDGEMLYSAGTDGLVKMANSESGQVQNKIAIPLESNGSIDAPTVIHALSPQTLLLATDSSALHLYDLRVPYSKVSARPEQSHHPHDDYISSLTPLPASETSTSGFSKQWVTTGGTTLAVTDLRRGVLVRSEDQEEELVSSAFIGGLPSSGTSRGEKVAVGGSNGIVTLWEKGAWDDQDERVYVQRDAGGGEAIETLVTVPDDMGMGKMLAAGLGNGLIKFIRVGPNKVASEVVHDETEGVVGIGFDVEGRMVSGGGQIVKVWHEAAGGDSLGKHMMDSDDSGDESDDSDSEQKRKAAANTNDRKKRKKGKAGRGTGPDVIAFDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHP0</accession>
    <name>A0A9W9XHP0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_001918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793552.1">
        <property type="nucleotide sequence ID" value="XM_056931521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHP0"/>
    <dbReference type="GeneID" id="81621770"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5493172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="64" mass="7304" checksum="476DC87FD87FD1B7" modified="2023-11-08" version="1">MSAPRGTGVCIVNKTHEASQKKLDKMDQLGIPLAPLTKYQAVPIQSDEEYLQYWRDHEPYDVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHT7</accession>
    <name>A0A9W9XHT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_001631</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIGH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793265.1">
        <property type="nucleotide sequence ID" value="XM_056931234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHT7"/>
    <dbReference type="GeneID" id="81621483"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044215">
        <property type="entry name" value="PIG-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019328">
        <property type="entry name" value="PIGH-H_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10181">
        <property type="entry name" value="PIG-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved" evidence="4">
        <location>
            <begin position="107"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5492885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="197" mass="21788" checksum="A3837D670D321EC5" modified="2023-11-08" version="1">MPGRLTVHRPTPTTASFTVSNAPRRSDPTAKVLFAFGILLRVLSFLCVIAVAITRARHHFFEEGSFLTIAWEDVWSSAAGRYACQLVDSYNPSVLAIAGTLILYGESLLVIRGFGIQTSTSSSTYLSTAATRFIPTTQIQDIVIHEAFKGFEVRFYLAVIVEGEPGVLVVFPQLLPGREVLEEVWRGSRRCLYDTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLB0</accession>
    <name>A0A9W9XLB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_000188</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the SRB8-11 complex, a regulatory module of the Mediator complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794085.1">
        <property type="nucleotide sequence ID" value="XM_056929792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLB0"/>
    <dbReference type="GeneID" id="81620041"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000095">
        <property type="entry name" value="Cyclin Ccl1, putative (AFU_orthologue AFUA_5G07030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0195">Cyclin</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="Cyclin-like" evidence="9">
        <location>
            <begin position="88"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="370"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5495072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="418" mass="46621" checksum="F5CF13F869C9CDA3" modified="2023-11-08" version="1">MIEDDFYRASSQYRLWSYTETSLQSIRSATNQIASDRVRAALRRAREQHLSSTTSAAVESQSEGATEEKNIECLTPDEELVLVRYYCEKTVELGETYRPPLPTNVRATAIQYLRRFYLTNSPMTYHPKSIMACALFVATKTDNHYMSLRQFAEGIPGDTTPEDVIAPEFLLMQGLRFTFDVRHPFRGLEGGVMELSAIAQGQGAAAPHLPHHTSDSLKRGILSLAPPPIACASVHDRIGRAHSATRELLKSAAQMTDAYFLYTPSQIWLAALLVADRPLAEFYLDTKLGGPLDSTNVGADASSHLQNPLYELRTKLSKVLMDCAALLQSYTPLSSDPAQMKSLKRIAKKLYHCQNPEKVNLKRDVAAPRLNPAVDSATPMSESETERLVKKRKTESQQIQQEGHSVFGPELVPDRTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLK1</accession>
    <name>A0A9W9XLK1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_000323</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TOP6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794220.1">
        <property type="nucleotide sequence ID" value="XM_056929927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLK1"/>
    <dbReference type="GeneID" id="81620176"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1360.10:FF:000018">
        <property type="entry name" value="Type II DNA topoisomerase VI subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="11">
        <location>
            <begin position="91"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="12">
        <location>
            <begin position="201"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5495207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="386" mass="43745" checksum="B89B03D2EC1AD741" modified="2023-11-08" version="1">MSQGSSSVPPASPTVEESQRLVREFIDDILINILDQVSLSPSESRPSITLRRRSNQTQCTINSQTRALEARLNDVTYHSYSWPGRTPFESWKFTVIIRILSIIDEAICTEQLISKRDIYYIDPAYFKSQATVNAVVDDLAFTIGVDRTFLNIEAASKGLVAGRFQLERESRVIVDASSGEDTMIPRVQGSDTIDIEGVRWVFIIEKEAVFHRLARSNYPKRAISGDGILITGKGYPDVSTREFAHQLFIASRRYDRPPHFYALMDSDPHGMAIMSTYKYGSMAHLHENARLSLPGLEWLGVRLTDAILASESPGAGRVLSLTANDRRKILAMLRKNPVWASDGPEREWVTELHRMLLLNVKAEIEILYEREGGLEAWIDRKLFRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM35</accession>
    <name>A0A9W9XM35_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">SNF2 family helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_000519</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794416.1">
        <property type="nucleotide sequence ID" value="XM_056930123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XM35"/>
    <dbReference type="GeneID" id="81620372"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF11">
        <property type="entry name" value="FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G06590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="366"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="691"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="762"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="194"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="194"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5495403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="933" mass="103737" checksum="29C780C6594BB592" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM79</accession>
    <name>A0A9W9XM79_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_000689</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794586.1">
        <property type="nucleotide sequence ID" value="XM_056930293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XM79"/>
    <dbReference type="GeneID" id="81620542"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990861">
        <property type="term" value="C:Ubp3-Bre5 deubiquitination complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000003">
        <property type="entry name" value="Nuclear transport factor 2 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF20">
        <property type="entry name" value="AT27578P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NTF2" evidence="3">
        <location>
            <begin position="65"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="340"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5495573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="561" mass="58121" checksum="CD4B97A718A50436" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMI5</accession>
    <name>A0A9W9XMI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_000120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794017.1">
        <property type="nucleotide sequence ID" value="XM_056929724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMI5"/>
    <dbReference type="GeneID" id="81619973"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF10">
        <property type="entry name" value="COPPER ACQUISITION FACTOR BIM1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040849683" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="8">
        <location>
            <begin position="25"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="9">
        <location>
            <begin position="24"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5495004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="243" mass="26247" checksum="BBD5207E555356B9" modified="2023-11-08" version="1">MSLQQLSWRWIALVAISWAAIAQAHSIITYPGYRGDNLHTNGTVAQANGLGIAYDPVNGSLYYPYGMEWAYPCGGMPTSKNRTYWPIGGGAVAVQPGWFQGHSTALIYINMGFGEVPENMSHPVVPPFQIVGPTNDPYPGTICLTQIPLPQGINVKVGDKATIQVVEAAKHGAALYNCVDIIFAENGDSKIKEVTADNCFNSSDIGFQYMYTTTGIGSGAEMLQPLRGIWLAFIPLLLALSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMV6</accession>
    <name>A0A9W9XMV6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_000998</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794895.1">
        <property type="nucleotide sequence ID" value="XM_056930602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMV6"/>
    <dbReference type="GeneID" id="81620851"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF15">
        <property type="entry name" value="PRNA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5495882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="840" mass="93361" checksum="E88AB793DE5AD198" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN74</accession>
    <name>A0A9W9XN74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794362.1">
        <property type="nucleotide sequence ID" value="XM_056930069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN74"/>
    <dbReference type="GeneID" id="81620318"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="50"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="333" mass="38061" checksum="B4919B2B05807798" modified="2023-11-08" version="1">MTSDVPVSHTNVVSESPQAVSSRNAMAPKRVLITYGVDVDAVAGWLGSYGGEDSTNDISRGYWAGTVGTRRLLKLFDKYDIKTTWFIPGHSLETFPEDMAAVRDAGHEIGLHGYSHENPTDMSIEQQRDVLDKTYRMLTEFAGKPPRGSVAPWWETSKEGAQLLLDYGIEYDHSMSHEDCQAYYLRTGDTWTKIDYTQKAETWMKPLEHGTQTGLVEIPSNWYIDDLPPMMFIKNASNSHGFVNARDVEDIWRDHFDYFYREYDEFIFPITIHPDVSGRPHVLLMHERLIEHFKKHEGVEFVTMEQVCDEFKKKNPVPDGALMPAPVGHVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XNA1</accession>
    <name>A0A9W9XNA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PAN2-PAN3 deadenylation complex catalytic subunit PAN2</fullName>
            <ecNumber evidence="10">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Poly(A)-nuclease deadenylation complex subunit 2</fullName>
            <shortName evidence="10">PAN deadenylation complex subunit 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PAN2</name>
        <name evidence="13" type="ORF">N7539_000836</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 2 metal cations per subunit in the catalytic exonuclease domain.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Positively regulated by the regulatory subunit PAN3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase C19 family. PAN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="10"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XNA1"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06143">
        <property type="entry name" value="PAN2_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000459">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000028">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000135">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit pan2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03182">
        <property type="entry name" value="PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030843">
        <property type="entry name" value="PAN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048841">
        <property type="entry name" value="PAN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20770">
        <property type="entry name" value="PAN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="484"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="10">
        <location>
            <begin position="316"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1158"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="875"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="877"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="984"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="1044"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5495720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1179" mass="130974" checksum="A2DFF6CFE65D1D6A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XNA7</accession>
    <name>A0A9W9XNA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_001242</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795139.1">
        <property type="nucleotide sequence ID" value="XM_056930846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XNA7"/>
    <dbReference type="GeneID" id="81621095"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000282">
        <property type="entry name" value="Glyoxylate reductase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF269">
        <property type="entry name" value="HYPOTHETICAL D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="68"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="127"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5496126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="339" mass="37104" checksum="C8E6C09B114FBB3B" modified="2023-11-08" version="1">MNSQENKPKVLILGSVNFAKDAYESLNQIVELVKPAAENREEFIEECRRGTFDDIRLAYRDFSSSRITGLVDQELIDALPRSLRFMASCGAGYDQLDIDACSARNPPLLVSNTPTAVDDATADANMFLILGALRNFNAGMHSLRQGKWLGQPIPSFGHDPRGKTLGILGMGGIGRNMKAKAEAFGMKVIYHNRHQLSDELAAGAQYVTFDELMSSSDVLSLNLPLNKNTRHIISTAEFAKMKDGVVVVNTARGAVMDEAALVQALESGKVFSAGLDVFENEPEIHPGLLHNQRVILVPHMGTWTTETLTAMETWAIDNVIQALTKGTLKSPVPEQSHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XNN3</accession>
    <name>A0A9W9XNN3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794928.1">
        <property type="nucleotide sequence ID" value="XM_056930635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XNN3"/>
    <dbReference type="GeneID" id="81620884"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="119" mass="12035" checksum="D08ECD7C2D65A46E" modified="2023-11-08" version="1">MSEAEGRSHARSAVSGGSGVESTPANNVGAGDSTRDEGSGHVAAPNLASTKGSFLGLTDQKSRAENNFMTRADEAAGVKGPVAGNDGTCATEDHSFMAQKPGTSDTLPGWDAVKNVISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ71</accession>
    <name>A0A9X0BJ71_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED17</name>
        <name evidence="10" type="ORF">N7539_008868</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJ71"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5469250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="648" mass="72365" checksum="0449590081F7DB2D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ72</accession>
    <name>A0A9X0BJ72_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_008899</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785871.1">
        <property type="nucleotide sequence ID" value="XM_056938494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJ72"/>
    <dbReference type="GeneID" id="81628744"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000137">
        <property type="term" value="C:Golgi cis cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5469281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="165" mass="18280" checksum="1587216B4DC2FFC2" modified="2023-11-08" version="1">MSRLNDCSKLNFRLIVLGGLFLFGGVLMFFDRSLYVCLYQSNIRPATISQTSKLTSFSTISRLAMGNILFLIGLTLIIGVQKTIVFFTRPQKLKGTAGFCAGIILILLRWPLIGFFVELYGLFILFGDFLVTIGQFAGNIPVVGTYIRRGLEILAGERSNAELPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJG4</accession>
    <name>A0A9X0BJG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_009184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786156.1">
        <property type="nucleotide sequence ID" value="XM_056938779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJG4"/>
    <dbReference type="GeneID" id="81629029"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5469566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="80" mass="8682" checksum="9B3351C1234E1FA0" modified="2023-11-08" version="1">MVMGQHGADSAISTPTQPYSIQITMSRERASAAELQTTNYSDNPIWHFSSSDRSAPAENSPQLVQSLAVLDSVKTENSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BND0</accession>
    <name>A0A9X0BND0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787309.1">
        <property type="nucleotide sequence ID" value="XM_056937444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BND0"/>
    <dbReference type="GeneID" id="81627693"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF4">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="168"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5475556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="470" mass="52062" checksum="7BE536FA63F65D80" modified="2023-11-08" version="1">MDLSRPLLEVGDALERRHSEASISPANPMSDSGVDFPHPHYAMIYLDHNGELRVKASASMAGCGGAIFTPEVTDNFVKLANPSPVTSALPSMNASPSQLFEGSPFTTRSSPGLMRTGPTGLAEMIPCQFLDQNKRRRRDSRRTSNAQPQYKPASPTPAPRPGHTVLRVGDRDLLRRYYEKAFEDFQQLNCRTIAKSYIKLVEPRKQVHFPYNGRKVIAGVAQRVDPEQTKPAWWPLGVLHREPDHLLKRDRLKLLVHILCELKDSHGITAQKLREAGQDVRRQITPTNRVQVLDEIYFVRELEERFLDGDLDANARIQVRHTHLPEAICHEDDLSSSIYIAPLSLMEDEQEDQDEDSYGVESHGMPLDDNAAMGPVAAHGLHPNPHGLPLSPTTSDSSGPHSPGTYGAYTTAMPSGVLATQPSPATIKDIPIESTYLAPCYGQQFMPSVKASAGYWPTMAQMPQNSSFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNM1</accession>
    <name>A0A9X0BNM1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787564.1">
        <property type="nucleotide sequence ID" value="XM_056936765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNM1"/>
    <dbReference type="GeneID" id="81627014"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040860482" description="Hydrophobin" evidence="1">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="10923" checksum="D1F2484B82F141C4" modified="2023-11-08" version="1">MQILSSILLAAGLATSVLCLDTPVPSAQTGPAPSAVTPAAQCQRVGSANPSLFEKNREAAALLPPNCDLQACLNVGPVLTCIVKALQNGNLIDLAGCLTTGIQEPYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BP17</accession>
    <name>A0A9X0BP17_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin synthase export chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787565.1">
        <property type="nucleotide sequence ID" value="XM_056936766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BP17"/>
    <dbReference type="GeneID" id="81627015"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF1">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="32113" checksum="AD22D17E11FDEA72" modified="2023-11-08" version="1">MGSTQFGNFHDFCRDSTLPVCNLFKANQPPGINYGGCVLTGIPLSGDRHLANLGSIILAFIAILVTIALLWRSDRKHAAVGRREIQLFLLGYLVIEICEIFTVGGFPLAESVRKGFTAVHLAAITATIWILLMNALVGFQLIDDGTPASIGLISASALALFIGTGYIALDTGFSWTGHFDSSLGNGNNRNIGLYVLYQLFPLVCLVLFFLLETVLVLRVLGEVRPMLYLVGAALLFAIGQIFQYVISTHLCQATSGKIDGALFETLFTLLSVISIWGFWSSITEDDWPLPVGSGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BP23</accession>
    <name>A0A9X0BP23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histone chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_007331</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with histones H3 and H4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RTT106 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787731.1">
        <property type="nucleotide sequence ID" value="XM_056936932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BP23"/>
    <dbReference type="GeneID" id="81627181"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF3">
        <property type="entry name" value="HISTONE CHAPERONE RTT106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="5">
        <location>
            <begin position="257"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="366"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5477187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="466" mass="50951" checksum="2AD6952709ACF338" modified="2023-11-08" version="1">MAFAAINSAVMHIPAIEEAFATEPSLKKRVYDAIGSTPQHTPLFEDLARHTSALLARTVKTTSLPLVPPPSEGPVVKKRKIQNGLAEELAQAPVNVKDDVPIQFYVQDVSFAIPQRKKLTLEVTAGYSYLRARNQTTKEVEFGVPMNRIRHALCLPVPEKTQKQFNFCIVPEFADGVTPPPEGMTAFEPMVFMIPDGPAKAAFDGSGQQVGNEAGDSGEALLRKILNQNLTTTSVVRPDERQFVSAMSEAHRKNEKAYHVKAFRGSKEGYLFLLSTGILFAFKKPLLFFSFDTIDSVSYTSVLQRTFNLNILARPNGGSGDAEGETQEFEFSMIDQADFDGIDAYIKRHGLQDASLAEARRAKKYNVNGGNKGEDGAPGAGDAGEEESELQKAQQEMEDLEDEDEEDYDPGSDDGSDGSGSSSEEDSEDDDDEGVDENDEAGSDGERDLVKHELGSETEDVGHEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BS47</accession>
    <name>A0A9X0BS47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thymocyte nuclear protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_006634</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788170.1">
        <property type="nucleotide sequence ID" value="XM_056936235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BS47"/>
    <dbReference type="GeneID" id="81626484"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21133">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.590.10:FF:000003">
        <property type="entry name" value="Thymocyte nuclear protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052181">
        <property type="entry name" value="5hmC_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000116">
        <property type="entry name" value="HMGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000637">
        <property type="entry name" value="HMGI/Y_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047197">
        <property type="entry name" value="THYN1-like_EVE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087:SF7">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02178">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00930">
        <property type="entry name" value="HIGHMOBLTYIY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00354">
        <property type="entry name" value="HMGI_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EVE" evidence="8">
        <location>
            <begin position="207"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5480740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="374" mass="41400" checksum="F723B1069C40652E" modified="2023-11-08" version="1">MSTMSDNDTGSPSKQIQEEMSGAIHPVEEITKSGTSPQTGEKRKRGRPRKTPDEVTKSSDEPKRGRGRPRKVLSETEIAAAAAAAASPGVKRGRGRPRKESGTTTAQPSTTPKKDGRGRPRKEQVATTDSPSTEPKKKDGRGRPRKNPAATPSTTPKRGRGRPRKSITTDEPVANTESKIEDPDEEDRATSQPVRESSPLEDTGRSYWLMKAEPESRLEKGVDVKFSIDDLAAAKEPEPWDGVRNPVARNIMKEMKQGDYAFFYHSNCKVPGVVGIMEIVREHSIDESAFDSKHPYYDPKSTPTAPKWVVVHVEFRKKFNNPVTLTDLKLHGQPGKALENLQTLKQSRLSVSSVTPAQWRYILRMAGEEVRANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSK5</accession>
    <name>A0A9X0BSK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_006756</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GLYK kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788292.1">
        <property type="nucleotide sequence ID" value="XM_056936357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSK5"/>
    <dbReference type="GeneID" id="81626606"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001691">
        <property type="entry name" value="Probable ATP-dependent kinase TDA10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5480862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="35699" checksum="9CAB6010E68DB34F" modified="2023-11-08" version="1">MIEIVDDKSKYCIPFLLERLRIHTARHPYNTPPFFLGLNGVQGAGKTVLVSTLQDLLRSEPYSLSVITLSLDDIYLTHADQLALARAHPTNPLLQHRGQPSTHDLDLGVQVFNSLASEQPTAIPQYDKSAFSGQGDRVPDSQWTVVNREGQKKVKVIIFEGWCVGFRACDEQTLHTKWESAVRAKESGNYQGRLGHLKYEDIQAVNEALKRYNVLTDKLDALIHIDAQDPRFVYEWRQEQERTLRAATGNGMSEDQVKDFVDGYYPSYEIFTESLREGVFRPQTGAANSLDWQGRQLRLVVNRDRRVEEIIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BST0</accession>
    <name>A0A9X0BST0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rhomboid family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_006364</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788890.1">
        <property type="nucleotide sequence ID" value="XM_056935966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BST0"/>
    <dbReference type="GeneID" id="81626215"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000004">
        <property type="entry name" value="Transmembrane protein 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="325"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="340"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5482918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="40055" checksum="878869FA8D28903E" modified="2023-11-08" version="1">MSMRLNIPSATRAVLIALLTLSLLYNIARWRQLDTTAGSVQTSPIIPYLTLVPSLFYQYPWTLLTATFVEQNIFTVLLNAATIFYGGKYLERAWGSREFSKFILAVAVIPNVMIVPFYLTWAALTGSSTRGLTQICGGVAIQGSFLVAFKQLVPEHTVTVFKGLIKMRVKHFPALFLLLNTLSGFIIGTDTAAVLAWFGLLTSWTYLRFYKRQPDLTGTSTNGQGIKGDASETFAFACLFPDVMQPPIAFVADKIYTSLVSLKIITPFSEDEIASGNQQVLARGEAGLPTLLSNQRAAGRGSGKREEAERRRALALKALDQRLQAAAGGRAQAGPSSQGESASHRSGTPTSSAPSGHNVLGGTNYNPDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BTU0</accession>
    <name>A0A9X0BTU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenylacetyl-CoA ligase epaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000007">
        <property type="protein sequence ID" value="KAJ5483836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789106.1">
        <property type="nucleotide sequence ID" value="XM_056935638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BTU0"/>
    <dbReference type="GeneID" id="81625887"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF265">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="446"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5483836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="549" mass="60759" checksum="DF35FCD7BBFB78F6" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BTW0</accession>
    <name>A0A9X0BTW0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789328.1">
        <property type="nucleotide sequence ID" value="XM_056935456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BTW0"/>
    <dbReference type="GeneID" id="81625705"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5484058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="291" mass="32578" checksum="4CC812DE7C9B3FE6" modified="2023-11-08" version="1">MGVPAYFELSWSILSTIGLFLTVAGLWATAITRLSRLHLVPIIVSIACSIANGLCYFAFYTQNPIRQRAAASVFADTFWLVQEAGLSFYSYQILVHTLKDRAFLIFRAIFWSLMTCIIALRITIAATRAVELATNQPFQTRVDYLHLGYFTAIALVEVSSATFLIRLLRDAYGTSPWSSPTRGVFRHLLQSTEIRLASLSCIGILRAVTYSLQTTAQSATTVAGEFDRFAYTLECLFPTVMIIDILASKRFQLDGHSTLHCSDPLEEQQEWAGHRDGRSAPRAEMSPRSVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BTZ6</accession>
    <name>A0A9X0BTZ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_005928</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789402.1">
        <property type="nucleotide sequence ID" value="XM_056935530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BTZ6"/>
    <dbReference type="GeneID" id="81625779"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5484132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="242" mass="27037" checksum="A9A6D56EC194070A" modified="2023-11-08" version="1">MSAQRSVLAAENRFFSRSAFQHQQHASAAPFNSPQSQHRNTSTIHKLTTKEPRYYTLSLILGTVALAYGSVPLYKMICTQTGWGGQPILTHRTGDGDTASRVTPVTDSRRLRITFNGSVSDVLPWKFTPQQREVRVLPGETALAFYTATNKGPQDIIGIATYSVTPGQVAPYFSKIQCFCFEEQKLNAGESVDMPVFFYIDPDFATDPNMKGIDTITLSYTFSDERLYADCLQKRNMTTMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BU41</accession>
    <name>A0A9X0BU41_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789391.1">
        <property type="nucleotide sequence ID" value="XM_056935519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BU41"/>
    <dbReference type="GeneID" id="81625768"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5484121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="203" mass="23080" checksum="8BE0089C3ECACAA0" modified="2023-11-08" version="1">MNFGFPVSIIRPAERSSEIVIMESSSRLSSSHHLFRRANSYSNSLPRSQHRCPLGRRKLTTDPRELESRARDILEPMDSGQPSRAVHGHPAHAVDAKGAPVQPSPRLHSATLEKPDDADDVTRRTRTVDPPKMLFDPRDPTPLRELTNYHDDDDDEDEDDDDGDVDDSKLLLQPKPQTRKEMDSNNGREEEKKKFYTSTLNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUI6</accession>
    <name>A0A9X0BUI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789675.1">
        <property type="nucleotide sequence ID" value="XM_056934481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUI6"/>
    <dbReference type="GeneID" id="81624730"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5484891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="65" mass="6876" checksum="87FDCE6A087CA085" modified="2023-11-08" version="1">MGAVVSCITSVFHAIGRCLMGIVNAIGSVLRAILDGIITIFDVIISCLTCQGCSGRRHRRSRSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUX4</accession>
    <name>A0A9X0BUX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790423.1">
        <property type="nucleotide sequence ID" value="XM_056935229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUX4"/>
    <dbReference type="GeneID" id="81625478"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="258" mass="28529" checksum="4B7A894B6B21023F" modified="2023-11-08" version="1">MSATDAQAKDVNRSYDQIILFGDSITEMSWDQGLGFGYGAALSDAYRRKLDVVNRGFGGYTTAHAIKIVHEIVPSPDVAKVRLMTVFFGANDACVPSHVQHVPLEIYKENLQNIIQHPATRAQNPRLVIITPPPVDEYQLEGFDKSKDTVYPSRTAQRAKEYAEAAKEVGASLKIPVADIWTAFMAAVGWQEGQALIGSRDTPMNSKFGSLFTDGLHLTAAGYRLVYDEVRKTIRAHYPDQDSDALPMLFPAWGEAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXR9</accession>
    <name>A0A9X0BXR9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_003513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790656.1">
        <property type="nucleotide sequence ID" value="XM_056933115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXR9"/>
    <dbReference type="GeneID" id="81623364"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="89"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5488623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="358" mass="39526" checksum="663A674B652B4EE1" modified="2023-11-08" version="1">MDFSEYTGPSAEWLAIEPTLPAMPQMPPLELRDMVNKGREELAAEGIKEIASQVQMQDYIVTTRDGASLEVRTYRPSTIANSEKLPVYIHLHGGGYLFGTLASEDGICSRIVVSRMQNNTPVVVLNVNYRHTPEHQFPIAWYDVEDAFVWLHDNIDQIGGLADQVVVGGISAGAHLTASLTLTQLYGDNERVKSCPRIRGQVLMIPALVSAKYYGNRKEMLRSPEVSSYVTCANAPILPVSRIDLFMKLLNIDRYPNAARDLRMNPGNVTAEEVKGLPPTTFGVAGNDPLRDEGLLFAKMLCENGVPADVHVFPGLPHGFRRWFGKSATGKKWDDVMSGGISWALSNPTVQPFTIKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXU5</accession>
    <name>A0A9X0BXU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790882.1">
        <property type="nucleotide sequence ID" value="XM_056933341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXU5"/>
    <dbReference type="GeneID" id="81623590"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563:SF17">
        <property type="entry name" value="DIHYDROXYACETONE PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="212"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="791"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5488849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="812" mass="91368" checksum="C8CA44C658714C08" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYP6</accession>
    <name>A0A9X0BYP6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CHY-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_004488</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791631.1">
        <property type="nucleotide sequence ID" value="XM_056934090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYP6"/>
    <dbReference type="GeneID" id="81624339"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039512">
        <property type="entry name" value="RCHY1_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017921">
        <property type="entry name" value="Znf_CTCHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037275">
        <property type="entry name" value="Znf_CTCHY_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319:SF0">
        <property type="entry name" value="AND RING FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14599">
        <property type="entry name" value="zinc_ribbon_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161245">
        <property type="entry name" value="Zinc hairpin stack"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51270">
        <property type="entry name" value="ZF_CTCHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="6">
        <location>
            <begin position="306"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="CTCHY-type" evidence="7">
        <location>
            <begin position="375"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="641"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="650"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="678"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5489598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="77014" checksum="37496922BD929112" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ82</accession>
    <name>A0A9X0BZ82_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792046.1">
        <property type="nucleotide sequence ID" value="XM_056932087.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81622336"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5490917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="11143" checksum="08FD8AC0E5E25761" modified="2023-11-08" version="1">MEATTSLLKRDASSPSNYPAYVLAIIVGCIACVLIGYGIFTMYHGVEEETYRELSQQQRQYMHEVRQRTLDDLEAASRRYTRAHDSPRETPKKMQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZI2</accession>
    <name>A0A9X0BZI2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_002890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792452.1">
        <property type="nucleotide sequence ID" value="XM_056932493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZI2"/>
    <dbReference type="GeneID" id="81622742"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="536"/>
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    </feature>
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        <location>
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            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5491323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="903" mass="99345" checksum="CDA221DC227F70AE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZS6</accession>
    <name>A0A9X0BZS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Penicillium diatomitis</name>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAJ5492728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_056931077.1"/>
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    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852:SF1">
        <property type="entry name" value="HIG1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852">
        <property type="entry name" value="YALI0B21208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5492728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="208" mass="23145" checksum="8FCBE213172327A6" modified="2023-11-08" version="1" fragment="single">MESQSSSSRLPEESSTLLKLVYWHRLFESDTPPRLGIDVQRRIPYAFMSAFSAGMALGYLHGSKKAGLVFRAENAHRFPTTSAGWFQYHKTKNYISVVGGVKDGFRMGMKLGGGALAFCLFEETVDYARHDERDFLSTVTAGLSCSGIYSLLARHDVYTAARTAKLGLKMSLAYGLLQDVLETMKGNSPSYVDFALGNRRFKRDEGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZW2</accession>
    <name>A0A9X0BZW2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
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    <reference evidence="2" key="1">
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                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793066.1">
        <property type="nucleotide sequence ID" value="XM_056931035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZW2"/>
    <dbReference type="GeneID" id="81621284"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="209" mass="23165" checksum="B8286582B40A448E" modified="2023-11-08" version="1">MAGRAETRTPEPPDRDEHEASPPRLTRPRRTTRPPNNYTQEQEIGTEQRLTRAQSKKKCQGKAVLQHDAVSSDDASTESEDLSATNLLKELVKLRKEIRRRDDVHKNLQTLADRSPTPQALSEPCSQNGHDEILREIHSLRIAINPSDPASGSLSYADIARTPLTSYPSNLVKEVSEAKVGAGARVLRDELHPIKVDSVNKAAVLDEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZX8</accession>
    <name>A0A9X0BZX8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein MSH3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">DNA mismatch repair protein msh3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_001728</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer of msh2 and msh6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793362.1">
        <property type="nucleotide sequence ID" value="XM_056931331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZX8"/>
    <dbReference type="GeneID" id="81621580"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03285">
        <property type="entry name" value="ABC_MSH2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000003">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000523">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000015">
        <property type="entry name" value="DNA mismatch repair protein Msh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000017">
        <property type="entry name" value="DNA mismatch repair protein Msh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032642">
        <property type="entry name" value="Msh2_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="16">
        <location>
            <begin position="737"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="861"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5492982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="940" mass="105267" checksum="9B8105CE9C2E8472" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0A7</accession>
    <name>A0A9X0C0A7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793767.1">
        <property type="nucleotide sequence ID" value="XM_056931736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0A7"/>
    <dbReference type="GeneID" id="81621985"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019433">
        <property type="entry name" value="GPI_ManTrfase_II_coact_Pga1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28022">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28022:SF1">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040777878" evidence="2">
        <location>
            <begin position="22"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5493387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="259" mass="28434" checksum="FAE4937285C00732" modified="2023-11-08" version="1">MKRSIPTVLSLLSFFTSVAQANVEKTIFLGPPAVAIPPDTPHLDPLGMMHLSPQNSVVRTYLNASFPTVEIPQGIESWFFLEDLTPGQRYEARICWLATQPTSFTLTTYTLSQAMNDPILLSSLSKYSTSHLAALAASAAAAAAIDDRPVETSPLTQQRPQETTLINDSILFLRVQAAADYFSPDQALMQRVPPVVVDVILDPFLMNVFPRSLVPTAAWMGVVGVVAVVVAKWVGRELGRLIDDARAERDEVEKEKKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0C9</accession>
    <name>A0A9X0C0C9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uracil-regulated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002089</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793723.1">
        <property type="nucleotide sequence ID" value="XM_056931692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0C9"/>
    <dbReference type="GeneID" id="81621941"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005536">
        <property type="entry name" value="PRK07198.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="7">
        <location>
            <begin position="27"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="6">
        <location>
            <begin position="260"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5493343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="444" mass="49226" checksum="D5B4AA333902C586" modified="2023-11-08" version="1">MLETESIPKMPEPTVPSSVSPKSHYSKHIILTTYPGQSGIDPVPLEWGAADAKSRGPVVVSRSNNLVKRRNAIGAHGGSYSIYNALAVAAGELDADFRPDLRNSQPTFNFPWQQAWGDKTKIVSMDPFGHDIVNQYKEELEAGWDIRPTMAVTRANMKLAEIADAVRDGQLEVDGSIVVDSSGEVRVTKVAVEPVWYLPGVADRFGVDEGTLRRALFEHTGGSYPELITRPDLKVFLPPIGGLTVYIFGPPERVSDEKVKLALRIHDECNGSDVFQSDICTCRPYLAFGIREAIREAQNGGSGVVIYFRKEGRALGEVIKYLVYNARKRGGDTADKYFTRTENIAGVRDMRFQALMPDILHWLGVKKIDRMLSMSNMKHDAIVDSGIKILERIPIPDEMIPSDSRVEIDAKIHAGYFTTGKQVSASDLAAVKGRGWEKWEDVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0H7</accession>
    <name>A0A9X0C0H7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_001866</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793500.1">
        <property type="nucleotide sequence ID" value="XM_056931469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0H7"/>
    <dbReference type="GeneID" id="81621718"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46283">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-CH-type" evidence="9">
        <location>
            <begin position="83"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="353"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5493120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="507" mass="55463" checksum="CAD06B07716819CE" modified="2023-11-08" version="1">MTSLPSVPTTGRRTSADEIAHSSPASEQHIVSAQDPVESTEDEDTETIILDRTAATTGSPETKAPVSTEQALAKSTSSPGPTDTQDEPRKCWICYTDETEDSPLNSEWRSPCPCALTAHEACLLDWLADMENPTSRKRTGSGAKMSCPQCKSEIVVTRPRSYVVDALRLMERIAGRLVLPGMVFTVAGTMWAGCCAHGIYSMYLVFGTEEAKQILEDSVDGPWNPGMNLGLPLIPLVLIFSRTRYAEGLLPAIPVLFFAAHSPGHEPSFDLWPPTSAMTFAALPYVKSFYGAVYDRVFGGLEKKWIAEVQPRATEETMDEVQQQDQAEGLNRFGDNMNGQILMEIDLELQVGMGGDDEPLVDQPIPAQQNQDGADLDAQDGQAQGQDAGQHNGGGVGRRRNEIIADTSSLADTVLGALVFPAISASMGGLLKYALPKAWTTPSSVLEKGRPNLLQTRWGRSVVGGCMFVLLKDALVLYCRWKLAQTHRRRKVQDYDRSKKLHHGRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C244</accession>
    <name>A0A9X0C244_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">VLRF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_000303</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The VLRF1 domain mediates binding to the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ANKZF1/VMS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794200.1">
        <property type="nucleotide sequence ID" value="XM_056929907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C244"/>
    <dbReference type="GeneID" id="81620156"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047139">
        <property type="entry name" value="ANKZ1/VMS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041175">
        <property type="entry name" value="VLRF1/Vms1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036">
        <property type="entry name" value="ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036:SF2">
        <property type="entry name" value="TRNA ENDONUCLEASE ANKZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18826">
        <property type="entry name" value="bVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52044">
        <property type="entry name" value="VLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VLRF1" evidence="12">
        <location>
            <begin position="219"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="553"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="553"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="596"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5495187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="635" mass="70878" checksum="75EB2C445DF64BC8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2T4</accession>
    <name>A0A9X0C2T4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome c oxidase assembly protein COX15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_000922</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794819.1">
        <property type="nucleotide sequence ID" value="XM_056930526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2T4"/>
    <dbReference type="GeneID" id="81620775"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01665">
        <property type="entry name" value="HemeA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5495806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="454" mass="50431" checksum="7B3044D9B6FCFF00" modified="2023-11-08" version="1">MPSPKPKMTRTSVLADKNRQFFTSSLRRSVAAPTVEAAAEQTAAKVKSSFPKISDKRVAYWLLGSAASVFGIVVFGGLTRLTESGLSITEWRPVTGSLPPMNADDWESEFSKYRASPEFQLLNPNMTLSEFKSIYYMEWIHRLWGRFVGLSFVLPAVYFIARKKVSTPMALRLGGIAGLIGFQGFIGWWMVKSGLKDDLFAPGSHPRVSQYRLTTHLATAFTCYVAMLWNGLAILRSHRLMKDPSEGLNQLNALRDPRLAFFRRSVAGLALLVFVTVMSGGLVAGLDAGLIYNEFPYMGKGLTPPSAELWDPRYSRHEDRSDLWWRNMLENPSLVQLDHRILAITTFTSIVALFAYSRRAPIKRLLPAPARKGMHGVLGFACMQVALGISTLLYLVPTPLASAHQAGSLFLLTWVMILGSRVWHPSRTAKLLQMAAKARGQQLSSSTASAMKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C340</accession>
    <name>A0A9X0C340_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SUZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_001237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795134.1">
        <property type="nucleotide sequence ID" value="XM_056930841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C340"/>
    <dbReference type="GeneID" id="81621090"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024642">
        <property type="entry name" value="SUZ-C"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="87"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ-C" evidence="3">
        <location>
            <begin position="226"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="205"/>
        </location>
    </feature>
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            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5496121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="30824" checksum="E9226C8080AABAB8" modified="2023-11-08" version="1">MSTNHEVPNAWDADWESQADQLADQPIIAPEKKISSKVSKAQRRAQQAEFNRQLWAEAEAPQTFHYMEARSEVPLKQDFKPTVTLLSRRPQTATRKSPSLGGVDGATAGLGQLGLDDDGDSDDDRSKQRQPTFEERQAMALKNREERQRKYEEARERLFGSPSAPTSGNSTPRSTTPPHHNQSAEGRGKGKGRGGQRDYREKRDSSSVSNRSRQQLYDPASPNRSTGGSPFQRRDRSRGDKTDVEKTELPQQPIRNPRGPDASGRGGFGFGPRGARGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C365</accession>
    <name>A0A9X0C365_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lysine--tRNA ligase cla4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_000920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794817.1">
        <property type="nucleotide sequence ID" value="XM_056930524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C365"/>
    <dbReference type="GeneID" id="81620773"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5495804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="181" mass="20501" checksum="6217583AB2801458" modified="2023-11-08" version="1">MLDTLVGEFLESTCINPTFIMSHPEMMSPLAKYHRSKPGLCERFEAFVATKEICNAYTELNSPAVQRERFDEQARQKDQGDDEAQLIDENFCQSLEYGLPPTGGWGMGIDRLVMFLTNNYSIKEVLAFPMMKEDKTAHHGKSVLEAVNSKPQPEEGNRMILISANFHEPISLTMNLQPTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKB8</accession>
    <name>A0A9W9WKB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785638.1">
        <property type="nucleotide sequence ID" value="XM_056939143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKB8"/>
    <dbReference type="GeneID" id="81629393"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5466592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="346" mass="39825" checksum="16EF24DCACC99D5B" modified="2023-11-08" version="1">MLFSPSGPQSPRRRSRLNAIFLTIGIVLAIYFLFFAGDERSHSRSYKDKADKYAHKIESVAANTVGQDDLAPSAVRRHKEMVVASMKGDDTSWLAEYFYDWSRKIYVVNDKTAPLTVAMNKGRESMVYLTYIIDHYENLPDLILFIHSNRYQWHNDDPYYDGVPMLRNFQTSYLQQEGYVNLRCVWVLGCPVEIHPLSDVHRDDVHAGEYFKKAFMELFPQTPVPEEIGVSCCAQFGVTRELVLSRPKSDYEFYRKWLMETDLGDDLSGRIMEYSWHMIFGKEAVHCPDAKSCYCNVFGLCDLNCAEPNGCDDRYVLPPFSALPKGWPYVGWNGQEQDPTHGLPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKH8</accession>
    <name>A0A9W9WKH8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear protein DGCR14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_009453</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785770.1">
        <property type="nucleotide sequence ID" value="XM_056939048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKH8"/>
    <dbReference type="GeneID" id="81629298"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="407"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5466724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="54369" checksum="BEBB3CACD045F925" modified="2023-11-08" version="1">MASPSSSNALVKRPDNQLMPPPPAPKRIKRPATVLDEDVYTSALSHIIARDFFPGLLETQAKQEYLDALDSKDKAWISSAKKRLADVMRTPTPGSNARRKTRNGSMAGTPVHFPASRSDETPRGWAGDTPMSVASTATSTSTIKDSVIPDVSHMGLTAFQAKYTSEDNESFNKVLDKQNTKKRENYAFLWNNNKIPSARQIAHHKQEIKRITAQGGNPQTSLIKQVDADADADAEHLIKTDLDARPARPDAWKFRPDNGLMFLPPSIEHTHETLQQQAEIASRAGPKRTLYQNTRLLDHDAAAAADAAASSIPPSPALTAIKDAIAGRPHLGESEASAIPGGETPRVNGYAFVDEDEPEPDYGPETSSADDYQADWRLLGSSSDTTPNPFQIGETRKREALHHRMVDRASRTKRAEKAAQTLKTPVTNTPRFASSPRIDFGLRGTPVGAGVGSGPSAGARTKMLTPAAQKLLSQVGGSTPRGSGSGSTGKSGLGNLWTPTPRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKI5</accession>
    <name>A0A9W9WKI5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_009443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785760.1">
        <property type="nucleotide sequence ID" value="XM_056939038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKI5"/>
    <dbReference type="GeneID" id="81629288"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5466714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="240" mass="26702" checksum="665889D5541717FC" modified="2023-11-08" version="1">MEIARFNDSAITMNLCLRAAGIEYCIIGGFAMSQLSEDRETKRIDCIANASQRQIVDAVDAVDHGVGLTATLPKNRDDYVDLQWTELDLDDKSDPVPIRVFCSIYATARARPKTYLIRPTPRQVTGETCGSGTVNFHSPVDLFKASLAAAGDRCSYPDSLDLRLLLEEFDEDIKPQLDGIALVHIGRAIRQYRHLEGLFVELGVNVDKAKIAAMSFVPFRNPREDQDDVPRDLFEKLGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKN1</accession>
    <name>A0A9W9WKN1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785854.1">
        <property type="nucleotide sequence ID" value="XM_056938477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKN1"/>
    <dbReference type="GeneID" id="81628727"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5469264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="97" mass="11193" checksum="B51E52C6C271B9B6" modified="2023-11-08" version="1">MQQDSQPRRWWYRTTDGTAWSSLALFHHQSIAHTPSFDSGCSKRVETSANGSYHEVMLPPGKDVVEMWYFETKKHIHVCGMLLQWWISTAPPATNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL68</accession>
    <name>A0A9W9WL68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SQS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_009055</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SQS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786027.1">
        <property type="nucleotide sequence ID" value="XM_056938650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL68"/>
    <dbReference type="GeneID" id="81628900"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02646">
        <property type="entry name" value="R3H_G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034082">
        <property type="entry name" value="R3H_G-patch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="11">
        <location>
            <begin position="506"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="10">
        <location>
            <begin position="642"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="189"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="239"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="326"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="327"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5469437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="685" mass="75702" checksum="080CEEDBB6AB1AA7" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLB0</accession>
    <name>A0A9W9WLB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_009242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786214.1">
        <property type="nucleotide sequence ID" value="XM_056938837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLB0"/>
    <dbReference type="GeneID" id="81629087"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF128">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="8"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5469624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="438" mass="48305" checksum="9E9BC94BAE09B247" modified="2023-11-08" version="1">MTNKHRANNWIDGLRGVAALVVVTYHLCSCFANWLNSPAMEEHGSVHVFQYPFLRLIVGGRSSVALFFLITGYVNSYGTRERVRDGDAGLALVGLSKTTFTRTAKLVLPTNVALIIGWGVCQLNGYSVAAQVDSSWIRAGAVAPGPTLCSALWALFKNLTVFWHGGVGIYDHTYWTIPFFVKGSMVVYLTLLGTAYTQTRWTKLILAFLYIFAWSGGQSLADINVYAGMLLAELSVDYGPRATSVISRASSISMIIFGLFIASFPDENVDWMPWSRAINNLAVLVVPAGGEVNRYVISVGTTLFSFGVFFSQDARQVLSHSIMNFLGRISFPIYLIHNTLIRTILTWLVYRDSAMREGLHPVNAEGNPKYLKRGGILTFILGLSIFYAALFYTSYLWTIYVDPPCGRLVAWMSEKAFGETEGAGIAVKEEALKGALLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLF6</accession>
    <name>A0A9W9WLF6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_009234</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786206.1">
        <property type="nucleotide sequence ID" value="XM_056938829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLF6"/>
    <dbReference type="GeneID" id="81629079"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000007">
        <property type="entry name" value="ER-golgi SNARE complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="256"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="201"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5469616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="347" mass="38323" checksum="5792FD8FF5AD3AD4" modified="2023-11-08" version="1">MAGQSIQDRTGEFSAILGHAQKRLGASKVGSQRQALLTDAQKRQANGFSTSEQDRKTGRSEFARRARDIGKGITGTTAKLQRLAELAKRKTLFDDRPVEISELTYVIKQDLAALNQQIASLAALTQAQHPKSNRSKTDQEGEHNDNVVVMLQGKLADVGSSFKDVLEIRTKNIQASRTRTENFVSSVSSKSQSALDSQRSDSPLYNTSGRRTPQPGYQGNSSDVLTLDPSNPSPLGQSAMHSDQQLLVMEEAQSSNSYVQARGEAIEAIERTINELGGIFGQLAQMVSEQSEMIQRIDANTEDVVDNVEGAQRELMKYWTRVSGNRWLIAKMFGILMIFFLLWVLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLX4</accession>
    <name>A0A9W9WLX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786197.1">
        <property type="nucleotide sequence ID" value="XM_056938820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLX4"/>
    <dbReference type="GeneID" id="81629070"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5469607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="25469" checksum="2F6D2B7E318A780B" modified="2023-11-08" version="1">MSSQALTSSASSSSLLQPIRTFLQALTSPPTTPTYIPTLLSAFTTNPLPLIHEHGLPQLAPFLGRSFTGTDGIARYFQLLAEHLTIRDMSFEPETAWVADAEARVVVVRGKARFIWKGTGQGWDEEFVYRLGVATEMDRGEGEDGDAGGGELKVCEYRIWADTGAAYLARLGKLGDLLEGGTGGGVEGIHFDQDEDGEGERKKMEGRGETRASLNRKRSGHQDMLGAGLNIYGSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WRJ3</accession>
    <name>A0A9W9WRJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786493.1">
        <property type="nucleotide sequence ID" value="XM_056938111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WRJ3"/>
    <dbReference type="GeneID" id="81628361"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5471947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="195" mass="22502" checksum="1C962F6AB31E4902" modified="2023-11-08" version="1">MEDIPNEDFCLPCLERSDRLWHGGEPFRVYCDHTAACQPFPASLEGTRLEYLALITTIDRNFKYSAMNPDSYNAKITEATHNLNAEFTKAVGVHQRRYFDDQAGLESFCASRRASIDPEKPISEKGIPGALYAKATTKPRLQWGDHGWYIWQAAMKDFNRTMMKLIDEYDESDYVYGDETCLQAWIRKFPLPLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WT03</accession>
    <name>A0A9W9WT03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="2">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_008041</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5474975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786733.1">
        <property type="nucleotide sequence ID" value="XM_056937641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WT03"/>
    <dbReference type="GeneID" id="81627891"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000031">
        <property type="entry name" value="Asparagine synthase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000050">
        <property type="entry name" value="Asparagine synthetase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
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    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006949">
        <property type="entry name" value="PRK09431.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="6 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="14">
        <location>
            <begin position="2"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="11">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="360"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="13">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5474975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="533" mass="60122" checksum="1835221D14DCDB8C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WT53</accession>
    <name>A0A9W9WT53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_008090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_056937690.1"/>
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    <dbReference type="GeneID" id="81627940"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="TRP_C"/>
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    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF5">
        <property type="entry name" value="DUF907 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G06100)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040818697" description="ML-like domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="580"/>
            <end position="609"/>
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    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="22"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5475024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="720" mass="78121" checksum="285AB1FF85588394" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTG9</accession>
    <name>A0A9W9WTG9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_008302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786994.1">
        <property type="nucleotide sequence ID" value="XM_056937902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTG9"/>
    <dbReference type="GeneID" id="81628152"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF10">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 29-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5475236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="303" mass="31908" checksum="9D1EEBB010632A9C" modified="2023-11-08" version="1">MDPDQSFEEPTSTPLQLAAEQGHLQEVQRLLFESAEQPNEEPRGYYGKTALQAASANGHLEVVEVLINAGADTNAKGGNNGGKTALVLASGAGHISIVKKLVSSGASINTSPYRYYGRTALQAAAEGGHEDLVLWLLGQGADVNAPPAKVDGRTALQAAAFSGNARIVQILLERNARVNERPVRYKGLTALQAAAFQGHCKVVEQLIQAGADVNADGAGLNGYTALSAAAEGGHLEIVQTLLDAGANVSALSGNQKRTAMQIALARGHAEIGRICNGYLHSQMRMKTWNLRSHLEAQVVSETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTM5</accession>
    <name>A0A9W9WTM5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787022.1">
        <property type="nucleotide sequence ID" value="XM_056937930.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81628180"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1219" mass="132046" checksum="96245E5AD3D13CD1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTQ9</accession>
    <name>A0A9W9WTQ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7896 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787082.1">
        <property type="nucleotide sequence ID" value="XM_056937990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTQ9"/>
    <dbReference type="GeneID" id="81628240"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057218">
        <property type="entry name" value="DUF7896"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031:SF1">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25438">
        <property type="entry name" value="DUF7896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7896" evidence="2">
        <location>
            <begin position="544"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5475324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="732" mass="80449" checksum="4D63DAC29120A376" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTU4</accession>
    <name>A0A9W9WTU4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007697</name>
        <name evidence="2" type="ORF">N7539_009363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787163.1">
        <property type="nucleotide sequence ID" value="XM_056937298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTU4"/>
    <dbReference type="GeneID" id="81627547"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease III domain"/>
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    </dbReference>
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        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="6"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5469745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5475410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="149" mass="16738" checksum="B001305DBCCC5DEC" modified="2023-11-08" version="1">MESELNTNFEKVIGHHFHARDLIEEALEESGLASAGNVRLALIGDKVLDLMLLQRWYREGNTTGTEQGTSMLQAYACNKQLASRAKVLNLQRFIHQRPDLDRNVPDSTLATTVEAILGAVWLDSNEDVQQVDEVMEKLDLYPPSDRVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTV6</accession>
    <name>A0A9W9WTV6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_008297</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786989.1">
        <property type="nucleotide sequence ID" value="XM_056937897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTV6"/>
    <dbReference type="GeneID" id="81628147"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF67">
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    </dbReference>
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        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
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        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
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        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
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        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
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        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
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            <end position="226"/>
        </location>
    </feature>
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        <location>
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            <end position="334"/>
        </location>
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        <location>
            <begin position="377"/>
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            <begin position="418"/>
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        <location>
            <begin position="449"/>
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            <end position="502"/>
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        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5475231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="561" mass="61824" checksum="43634221BB3E4D4E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUD1</accession>
    <name>A0A9W9WUD1_9EURO</name>
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        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">N7539_007941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="PANTHER" id="PTHR37535:SF2">
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    </dbReference>
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        <location>
            <begin position="739"/>
            <end position="760"/>
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    </feature>
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        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="56"/>
            <end position="65"/>
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    </feature>
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        <location>
            <begin position="76"/>
            <end position="89"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5475654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="781" mass="90654" checksum="8DC83E1B35A2B17B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9W9WV67_9EURO</name>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">N7539_007289</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_056936890.1"/>
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    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
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        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
    </dbReference>
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        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
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    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="80"/>
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        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
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        <location>
            <begin position="359"/>
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        </location>
    </feature>
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        <location>
            <begin position="362"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5477145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="378" mass="41188" checksum="AAA143C1CBA8D33F" modified="2023-11-08" version="1">MESLPKVSSRSTLPVLTAPKPWNYHLTLDTLLKVCGKTIFSPFIGWVIVLCLRAQVTPVTDTAFILSVIYATTLTILLVARVINQRIAYGVPRQVDPANEVVLVTGGASGLGLLIAQIYAMKGTSVAVMDIRKMSDKEQDEVFGENVHYITCDVGDRRALESAKEEVEQQLGPPSIIINCAAAGIHGRPLLHLPAQDFEKTVRTNLMAAFSLYQTFVPNMMTETENGGTIVTVSSVLGQLSPAGLSDYSASKAGLSALHRTMEAELRGEEHIKFLLVETGQMATPLFGWIRTPSHFFAPVLDPLEVAREIVDAVDSGRGGVVRLPTFATLVSWYAVLPGAIQLIARYLSRIDNAVASATPQTERRETRISQQTEKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVH9</accession>
    <name>A0A9W9WVH9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrogen permease regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788039.1">
        <property type="nucleotide sequence ID" value="XM_056937240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVH9"/>
    <dbReference type="GeneID" id="81627489"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5477495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="547" mass="60828" checksum="132628A6A9F3E0C9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVP5</accession>
    <name>A0A9W9WVP5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein transport protein Sec61 subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_007666</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788066.1">
        <property type="nucleotide sequence ID" value="XM_056937267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVP5"/>
    <dbReference type="GeneID" id="81627516"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5477522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="125" mass="12626" checksum="6796CA553D857D3C" modified="2023-11-08" version="1">MASPRPASPLTSGAESGPDSKSAGAVAASGSSISRPSSPTPPGGPRAAMRRRATADHKESLRNARPASTRSAGAGGSSGTMLKLYTDESPGLRVDPVVVLVLSLGFIFSVVGLHVIAKITRKFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X210</accession>
    <name>A0A9W9X210_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788429.1">
        <property type="nucleotide sequence ID" value="XM_056936494.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81626743"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
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            <begin position="313"/>
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        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5480999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="455" mass="50741" checksum="80676463D11EAF95" modified="2023-11-08" version="1">MGRSDAPTGRESTQSISKSRWSFDSPSRPPTKYSNFRKGSKASSVEGRAGLKDLGSASLPRGSDEPREPLPFPEYAEPSPTESRDQVLFLPSRRTPATTASGSIEQFESPCVLSNDFADIPEHRSHKSKHMKPKVHIKPMLRKLSREESGSQSIDLSRSSTEQEGLGIYLNFERERERRQSDSMTGTGYRRTTPGMHNRSISGTSQFSTATGSSGGNAGSQYVYPLRPTPRSYSPPLHQSHQTSLHESDDESEGSPELQTKTRPELESHHTARTSSTTVPRPSLQIDDDPFTRLAGISQTNVSGRPSFGYSRDNGSTVDTTSPSSRPSLDFVFRNRTRTSTDPISRAATIQAARQAFEEKEAAKARRLEKQQLKAEERQGRRLVKRNSPEGQATPATTSTAQLSEKTDEIPHPKFTSSDHSSPSWKSQSKSTWVLFMTWLRTRVFKLRRKLRKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2A0</accession>
    <name>A0A9W9X2A0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AMP-binding enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788558.1">
        <property type="nucleotide sequence ID" value="XM_056936623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2A0"/>
    <dbReference type="GeneID" id="81626872"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF28">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="548"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5481128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="69960" checksum="BBFD13F77EC00DC1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2B7</accession>
    <name>A0A9W9X2B7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788524.1">
        <property type="nucleotide sequence ID" value="XM_056936589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2B7"/>
    <dbReference type="GeneID" id="81626838"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5481094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="173" mass="20057" checksum="0286B8DB9B05583C" modified="2023-11-08" version="1" fragment="single">HTKTLRLLRGKITPAIVKDKDTSILHELSYRNKRFRFFTHLYRNERNPAKKLIARFPLTYWIGEDCPGNADEKVRCGTSTYAWLEKDCATAPNPQLYSFGLSDGETFTFLDNLPIFTRTIKRLRRWLLSLLSYPATSRYSQHPTEGQLKLCTPYLLIKYINPSRGPGKVLSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2T5</accession>
    <name>A0A9W9X2T5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C6 finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_006645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788181.1">
        <property type="nucleotide sequence ID" value="XM_056936246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2T5"/>
    <dbReference type="GeneID" id="81626495"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF44">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5480751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="50722" checksum="45247CFF38F4AADE" modified="2023-11-08" version="1">MDRGIECEGYEVRLRWGCGIASRGQFTGADKPLRESVPPRPRGRRRDWSRERKRGAGQGLNPSSSEILGSEDATQSRMTAVSDPGALPESIRSDRDELLFTEFLTTGINVLHSTTVSENLLQPRLPALCKESSALYDICLTFQLSLTSTQTTQFLEYFDRSLREFRTELAQSTRLSDGTFTAGLLLCSIGLVHGMSWTMHIEGMYNILRSTDFAPLPEWNTLRPFRIHLLEVLGVMDIPCLTVGRQIGSFGIWRRICQSLRPRVGVEPVTGLPRSFMDLLAGIGIDTSEQSFWDWPAEPGNFLQCYLWEAYRLAGILYLRQIERKTPTSSGPQTLPTWRQQNSCPIDSNMLVARVLANVDALRLGCAERPDEDSFIQNSSLFPLVIVGKEVHIMRQNSQWQEVIRRCTLELHRDGIIFEILEEMWQDGQKTPDIDERARARGVEVGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2W0</accession>
    <name>A0A9W9X2W0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_007066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788602.1">
        <property type="nucleotide sequence ID" value="XM_056936667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2W0"/>
    <dbReference type="GeneID" id="81626916"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF0">
        <property type="entry name" value="FI21273P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="3">
        <location>
            <begin position="23"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="112"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5481172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="388" mass="42791" checksum="656A0C436674C279" modified="2023-11-08" version="1">MLVHRFEPPRQKTGSKSKTTPPNITVVTRVRPISSEEGSWGLVVAVCSRSDSIGAVDLHKLRRVVGGVPPLIVILLISIGADVQTKIIYDDVVHSLIPWAWDGNVGTLFAYGQKGSGKTFTVRGLEHLVAQSLFDGTLEGERNLYLAIFELAGNSAYDLLSARAPFPVREDHLGTTQLVGIQESQIGSTPELLALLNTANELRRSAHTVKNDGSLRSHAVCRIRIERPSQEPGRDGILYLIDLAGSEAARDVFSHLTERMKETRELNMSLSVLKDYIRSMPGIDKGDGTAPSKAYIPFRQSTLTKVLKHLFDSSESRQCRTTVIACINPSFLDTGASKNTLRYAEMLCQSQPAPKWEVHYPSAHTMHDLSYRVANKEKQVPVLGLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3F3</accession>
    <name>A0A9W9X3F3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heat shock protein sti1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_006975</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Part of a larger complex that includes HSP70, HSP90, and immunophilins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056936576.1"/>
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    <dbReference type="GeneID" id="81626825"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000004">
        <property type="entry name" value="Putative stress-induced-phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000010">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000020">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000002">
        <property type="entry name" value="Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing)"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.25.40.10:FF:000027">
        <property type="entry name" value="stress-induced-phosphoprotein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
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        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="2"/>
            <end position="35"/>
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            <begin position="36"/>
            <end position="69"/>
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            <begin position="150"/>
            <end position="189"/>
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            <begin position="258"/>
            <end position="291"/>
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            <end position="365"/>
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            <end position="493"/>
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            <end position="567"/>
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            <end position="258"/>
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            <begin position="248"/>
            <end position="258"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00064323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5481081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="580" mass="63882" checksum="142E55F6F6E888A6" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X4J3</accession>
    <name>A0A9W9X4J3_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000007">
        <property type="protein sequence ID" value="KAJ5483807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789077.1">
        <property type="nucleotide sequence ID" value="XM_056935609.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81625858"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="207"/>
        </location>
    </feature>
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        <location>
            <begin position="303"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5483807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="334" mass="36798" checksum="FE9E3DB420298626" modified="2023-11-08" version="1">MNPKPPDPRAGRKPFPPLRRPSSISKSVTPPTPPELPTPQRTTQEKFFISTTYSTITARALSFRGQVLSGVTPLQLAKNGFHYQPLSGGGLVCCFAYCIWKVISSDLKQHLDSTDTHSSSTDTLPPPRSDPSPFLSSKREQPKKMTTDATTQTQAKPAQKVPPTAEEYSNDSRAPPPSSTTDPESRLPPPTVSPQPPHPTSSITTLPLSHQPTYASVLQHLTTTSPRSIPKTREPVPPTRPILTIEDLHRRFYNKPSPFQLESKTKKRSASQIRNNSVSATKSLSKFLTSALPAFSRFLAEMQPNSNNATRSRQAPTRLQDRLRSGTRYIEGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X531</accession>
    <name>A0A9W9X531_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methylenetetrahydrofolate reductase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_005834</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789308.1">
        <property type="nucleotide sequence ID" value="XM_056935436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X531"/>
    <dbReference type="GeneID" id="81625685"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="10">
        <location>
            <begin position="303"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5484038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="611" mass="69121" checksum="9A6FD6E928EA3942" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X534</accession>
    <name>A0A9W9X534_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_005785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789259.1">
        <property type="nucleotide sequence ID" value="XM_056935387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X534"/>
    <dbReference type="GeneID" id="81625636"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5483989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="282" mass="31831" checksum="B1D1EB8D3CAB7DFC" modified="2023-11-08" version="1">MTMSTFTEETTLDLERVKATEEFRPFETKLFNILHDLIQPGNKLEPTAAAAQINDLFPSNEEDSSKAAVSTEDQDDAATNPEAFLWSLWGLIIQVMRLVPPRHPGQDQMISLLQSLSELPARSLEIWGQFTPDIGQADPDGISEWINQNSFMARLVGKGLLSWDTLIVWMMRDVLEDDLPQEEMVQDCYISVASEWITHAGTTIYNQLSSQEMTEQQKRVMKGGKLYEGPAGLRVERWGFWKSRLAEASQQASEKVRPAATAAADRMAEIEEQAHVEKEMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5G2</accession>
    <name>A0A9W9X5G2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_004707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789503.1">
        <property type="nucleotide sequence ID" value="XM_056934309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5G2"/>
    <dbReference type="GeneID" id="81624558"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5484719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="90" mass="9744" checksum="8E99838CBE71EB80" modified="2023-11-08" version="1">MSLVFDPRRTGSCLMLTADKLTEEGNERRVAAGPETGGKNLDHEVRHCFAARAKFGARVEVGSALTAIPDAWLPLCNGNAFPFQAIPDMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5V4</accession>
    <name>A0A9W9X5V4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine palmitoyltransferase small subunit A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_004917</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789713.1">
        <property type="nucleotide sequence ID" value="XM_056934519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5V4"/>
    <dbReference type="GeneID" id="81624768"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024512">
        <property type="entry name" value="Ser_palmitoyltrfase_ssu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11779">
        <property type="entry name" value="SPT_ssu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5484929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13750" checksum="1C7B9BEB7DA4EBCA" modified="2023-11-08" version="1">MSSLLWLLTTLVRWVRLKIYQYEVTFAIYMLTPAEKFIFNSLLLTLVTMIATGIYIYLPDHLRAIYGHLYYYWVGERPFIATRLSTSAGSALADVATQSLDIVFETAKTAVAASTTEALGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5Z9</accession>
    <name>A0A9W9X5Z9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carboxypeptidase</fullName>
            <ecNumber evidence="15">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_005007</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="15"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789803.1">
        <property type="nucleotide sequence ID" value="XM_056934609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5Z9"/>
    <dbReference type="GeneID" id="81624858"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF190">
        <property type="entry name" value="PHEROMONE-PROCESSING CARBOXYPEPTIDASE KEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4 15 16" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041018608" description="Carboxypeptidase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5485019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="503" mass="54298" checksum="A08280696C67FC33" modified="2023-11-08" version="1">MTMTAVLFFAQIWWSIAARFFPKSPFNSQYLVQSLPEAPPLPTSWAGRLPVPGRVEGNDIFFWLFESESPVYDENLIVWLNGGPGCSSLAGLLGGNGPISFIGNSTAVERNPYSWTQLGNVLYVDQPVGAGFSTASYPYPVGNNEMVVADFVAWLDGFLTLFPHLISKKIHLMGESYAGIYIPYFAHALLKSKNVSRSLDIRSMSLGDGSWGNAAAMSSVGIGAYMQSQARMLKVPRGILNAFAAADQVCGFDEVLAQATNFPPPAKSPSQTVADIDRSIFNSSCYGPCAVYSTAMDYMDTASSAGSGIPCFDVYDIHHDCSAVPTMSLMTAFFSRPDVQDALHVNGSGTYSTCNSTILSILLGAPSVVPPAYSILPDLVTEHNISLHIYNGEWDMLLNHVGTELAIQNMTWRGAQGFSTAPRRPFFPDNPMPEWSLSGHPGETGGVGKAAGYWGQERGVSYHLFNGAGHSVFANKPREMFAYVRDVVVGEKEVGGVEDGGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6M7</accession>
    <name>A0A9W9X6M7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_005034</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789830.1">
        <property type="nucleotide sequence ID" value="XM_056934636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6M7"/>
    <dbReference type="GeneID" id="81624885"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5485046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="203" mass="22756" checksum="21322B10FABF4EAF" modified="2023-11-08" version="1">MLQREVLLGITGKDFVIVAASKAIMRGPTIIKAQDDKTRQLNRHTMMAFSGEAGDTVQFAEFIQANVQLYSMRNDSELSPSAVANFVRGELASSLRSRSPYTVNLLLGGMDPHTQQPHLYWIDYLASLARVPYAAHGYYCLSLLDKHHNPEIDLAQGMKLLEMCTDELKRRLPIDYKGVLVKIITKDGVKEADFDNDKIVRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X739</accession>
    <name>A0A9W9X739_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790143.1">
        <property type="nucleotide sequence ID" value="XM_056934949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X739"/>
    <dbReference type="GeneID" id="81625198"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045328">
        <property type="entry name" value="Kre9/Knh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154:SF1">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040761178" description="Yeast cell wall synthesis Kre9/Knh1 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="32495" checksum="41064151A6C15D16" modified="2023-11-08" version="1">MGLGKLWLGLISLLSSVAGQTLSGLAFKAGDEVNFVWAFDGMTTGRYDFDLCAGDESTGNYETLDRVISDTLFSPGDRISFRVNPLVGGNVANAYFLKITPVKPNEHWSGFTSHFTMTNMQGAFSPSIIDAVKSMQAITIPSFILPENDSLVDATPEVPLVDEPFSPSEAAHRITSTPNLVPTPTSPLEQDHNELRKRVVVNQHTVPWGLQTGLTKYAPMPKRAGSTIKPGSPTPQYPPFPFKIATTFLGQPTVQYTDNAYLTATAPFVENPAPHASAPTVDPGKQEWYEKLKAEFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X745</accession>
    <name>A0A9W9X745_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Defect at low temperature protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DLT1</name>
        <name evidence="10" type="ORF">N7539_005500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Required for growth under high-pressure and low-temperature conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DLT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X745"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038869">
        <property type="entry name" value="DLT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021:SF1">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040849682" description="Defect at low temperature protein 1" evidence="9">
        <location>
            <begin position="33"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="355"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5485512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="403" mass="44916" checksum="A31C85077344BC5D" modified="2023-11-08" version="1">MNPTLERFLNSSSFFFFSLVCLCLILLTPADAIYQCWVTDRLTNIFFIAGAYVLTFILAALIYATRLYTNRTALAGIPKAWIPIEEEDVTKSVRRLVVDGLARSAVITYQACPRDTTGEENSFSNYQDLLVDPERPPWGSVEHPGWSSPKSTDLPDLPYRTVILELPDLIEAKAVSTAPADDTLPNTMDPFPDMRAVEVLQRPPSMGVRQYLIHLGNLGVITSPSLVVEFTSLYERARFSSHQLREPEFRELMRLFADILRAIMPMPPPILEGIRDSISYQTETESMIGPSDVEGESDTVDHQIYDGAFTPTRSVSLRPSMASMWDARSGRSASSAAHSPLSRFSVRSGSYRGLQSLQTRSTESLRRVRSGQSGSSGGSVIRLARPQDPTDLPYTFNYAGRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7R5</accession>
    <name>A0A9W9X7R5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_005639</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790435.1">
        <property type="nucleotide sequence ID" value="XM_056935241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X7R5"/>
    <dbReference type="GeneID" id="81625490"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF134">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="7"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="9">
        <location>
            <begin position="420"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="544"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="95"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="499"/>
            <end position="500"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5485651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="62934" checksum="7F259DB5EE048835" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XC98</accession>
    <name>A0A9W9XC98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790539.1">
        <property type="nucleotide sequence ID" value="XM_056932998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XC98"/>
    <dbReference type="GeneID" id="81623247"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="73" mass="7791" checksum="21EE51248CD3F2A6" modified="2023-11-08" version="1">MQLGAGDWDWDWDWDWDWESGSLADLGASGTGGARGREAPLVGKGGSGRDGKTAAKARSLGSRIEHECPFNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCG1</accession>
    <name>A0A9W9XCG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790644.1">
        <property type="nucleotide sequence ID" value="XM_056933103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCG1"/>
    <dbReference type="GeneID" id="81623352"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5488611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="182" mass="21290" checksum="6D3F8CFBAA609275" modified="2023-11-08" version="1">MHKNIIACPELLNQMESFESFCQVRKYHVDLLLYWSKLIAYRVNIRSDEGDFDILAKLSDLALYLNQAADTQPSTGIIHLEPSQRMTDRVLRERSKYIFLADQMLEMVRFLTANPDMIQLSDLLKMYALQLGRLRCLDGHFLDDEYAAGMDRMAEELSPRWTENVGHWHYVAWTKLQSGMKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XD28</accession>
    <name>A0A9W9XD28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anaphase-promoting complex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_003967</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791110.1">
        <property type="nucleotide sequence ID" value="XM_056933569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XD28"/>
    <dbReference type="GeneID" id="81623818"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008401">
        <property type="entry name" value="Apc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28526">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28526:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05839">
        <property type="entry name" value="Apc13p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5489077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="19310" checksum="4050BF0B14DEFD25" modified="2023-11-08" version="1">MSKDSSVTHLHMHQPRLADLFEEFTKPHLSAATIASGSAQNFGPPPGGHQPGNANAATYGAASPATIPSFLPIEDIYLQPQYQPPNPEDEDDVVPDQHAAFGIARAMERRREAVWRDLGLEALVNGHGHGGGGITTTTSSSGAGGVISGPAATLRGSSGGAAAASSTAVRVRNAGRKMGGRRVISLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XD40</accession>
    <name>A0A9W9XD40_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791034.1">
        <property type="nucleotide sequence ID" value="XM_056933493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XD40"/>
    <dbReference type="GeneID" id="81623742"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5489001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="87" mass="11049" checksum="2F6B7347503A1A5E" modified="2023-11-08" version="1">MEYPNPCLLRPIGGSDHLDSIKVHPTRSAVRTIISIVIAPETHVKMTLFFWGVPFLFPGDIHYYYYYYYYYYYYYYYYYYYYYYYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XD60</accession>
    <name>A0A9W9XD60_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_004090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791233.1">
        <property type="nucleotide sequence ID" value="XM_056933692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XD60"/>
    <dbReference type="GeneID" id="81623941"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5489200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="402" mass="44578" checksum="2A30A617B78ED18E" modified="2023-11-08" version="1">MCLHTLHHYPTCGHIANWTVTSCQPYTATLRLLGQQGMFDHCQNVQTDHDLALFLDPSECQQCKLLADSGCMLDVSQDGNYSAIEGLQSPSPVLEVFGRLRTAEIQYMPHETPRSLPKFASNLDQPRSSQLTNVCECREEWLTSPSMPPVTDHTQCIGKSDSASFSPCQEILDFMLRDLSADEAAIADSWNILRENASAEAISPSSTQIGARGSRNSLRGAISRISRQFVKTQEYSHCPNSPSWFDFELSDESSIDSDSLFAKCCVKDPYVDNHKDESLPALCHVSSSPIAEYDSASIDENRLTDDFLWTYPPAISSEENLLERALSSDTQPINVSASELILSPAPLRVTKPPRFVSEESALENVMKEMQASNDKTRSSGLGPRMTGSKAIWTKLKNLLMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDS9</accession>
    <name>A0A9W9XDS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein FYV10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein fyv10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_004376</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791519.1">
        <property type="nucleotide sequence ID" value="XM_056933978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDS9"/>
    <dbReference type="GeneID" id="81624227"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="5">
        <location>
            <begin position="63"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5489486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="271" mass="29649" checksum="EE0E3B47D884E8AE" modified="2023-11-08" version="1">MSRSPSSATPKWHQFERKVEDIKPSKTDINYLVMDYLITNGYPAAASKFALEANVQLRTDMESIQERVEIRNFIHSGNIQAAIEKINEFNPQILDKNPALHFALLRLQLVELIRTCTSSPDGDISPALEFATAHLAPRAPTNPQFLDDLERTLALLIFPSGSLSPSLGNMLDPSLRKEIAQRVNEAMLQSQGARQEARLRGLVKLRAFAETRARQAKKDIPEKLDIGLLGDGGGDAQFSNTSNNPLNSGTIHNGGGDTVMSNSGDGEAMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDX6</accession>
    <name>A0A9W9XDX6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">agmatinase</fullName>
            <ecNumber evidence="4">3.5.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_003973</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>agmatine + H2O = urea + putrescine</text>
            <dbReference type="Rhea" id="RHEA:13929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="3.5.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791116.1">
        <property type="nucleotide sequence ID" value="XM_056933575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDX6"/>
    <dbReference type="GeneID" id="81623824"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
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        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF30">
        <property type="entry name" value="AGMATINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
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    <feature type="chain" id="PRO_5040975018" description="agmatinase" evidence="8">
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            <begin position="20"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
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        <ligand>
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        <location>
            <position position="211"/>
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        <ligand>
            <name>Mn(2+)</name>
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        <location>
            <position position="306"/>
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        <ligand>
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            <label>1</label>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
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    <sequence length="392" mass="42319" checksum="2B58D2D3FB92C4FA" modified="2023-11-08" version="1">MISNYLALLALSTLSAAHGDHGQVPMSGPHKSLWYNTLPGDGGTQADSVFSGISTFGRLPYFPCLSSEDESYDIAFLGAPFDTGTSYRPGARFGPSGIRQGSRRLNLYGGYNVPLEANPFVSDLKILDCGDVPVTSYDNAWAIKQIEEGHNSVLMRKPFTNAHKPGLSRAGKTLPRVITLGGDHTITLPLLRSINKAYGPVTVIHFDSHLDTWKPKVFGGSPSQVAAINHGTYFYHAAMEGLLKNDTNIHAGIRTTLSGPSDYENDGYCGFEIVEAREIDTIGTDGIIKKIRDRVGTENPVYLSIDIDTLDPAFAPATGTPETGGWSTRELRTIIRGLDGLNFIGADIVEVAPAYDTNAELSTMAAADVLYEVLTIMVKKGPLSVDGREHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE61</accession>
    <name>A0A9W9XE61_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056933885.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81624134"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
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            <end position="239"/>
        </location>
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            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="399"/>
        </location>
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            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
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            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="602"/>
            <end position="612"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="653"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="742" mass="82606" checksum="28AE12249F6F7A7B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF61</accession>
    <name>A0A9W9XF61_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_002626</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056932229.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81622478"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5491059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="61814" checksum="4A8704675A511D4E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFG9</accession>
    <name>A0A9W9XFG9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_002806</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792368.1">
        <property type="nucleotide sequence ID" value="XM_056932409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFG9"/>
    <dbReference type="GeneID" id="81622658"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF14">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="100"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5491239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="25492" checksum="A0A94FCD33B887D1" modified="2023-11-08" version="1">MGGHIKPLILHAHATGPNPVKIAMALEALNIPFTVKNWDFGDDPKKGVKGEAFLKINENGRVPALEDPNTGVVSWESGACMNYVRRVYDNGNKIGPSGGTAQDLVDFEKWEYLLLTTLGPMMGQVNWFRHYHKQENKDALERYVAQAYRCYDVLEGQLQKSDGMSILPGRITAVDYHYEPWLRQHEFAGLSLEKYPMIHKWLSLMRTREEVQEAYIKIQNASKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFI7</accession>
    <name>A0A9W9XFI7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_002853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792415.1">
        <property type="nucleotide sequence ID" value="XM_056932456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFI7"/>
    <dbReference type="GeneID" id="81622705"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5491286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="322" mass="36948" checksum="EEDBE22E84BF593F" modified="2023-11-08" version="1">MSEPEAIAVDPDTYAVASAYWPDDWQSETTSIGSSIYRGLIENGRRYQALRNKEYLIPADDAQFEAYEAGHLCALILESNHDNPFFRAPVKSPQNILDIGTGKGTWAIDVADMFPEATVRGVDLFPPPVTWVPPNCVLEVDDVQQEWTWHEPFDLIHMRIMIGSFEEAEWERLYKQCYDNLKPGGWIEQLEVSPMIQTDDGSLPPDNILNDWGPNMLACGERAGRGVDTFDTMTNKIQKAGFTNVHQKLYKWPIGPWPRDKELKEAGMVNHQHWSSGLEGWCMWLLTRYGSPSPWSQEEVQVYVARLRNELLNPRFHIWHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFV5</accession>
    <name>A0A9W9XFV5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792634.1">
        <property type="nucleotide sequence ID" value="XM_056932675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFV5"/>
    <dbReference type="GeneID" id="81622924"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053275">
        <property type="entry name" value="Agnestin_monoxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038732">
        <property type="entry name" value="HpyO/CreE_NAD-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38688:SF1">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38688">
        <property type="entry name" value="PYR_REDOX_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13454">
        <property type="entry name" value="NAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="395" mass="42775" checksum="2503D4340CB338BA" modified="2023-11-08" version="1">MATKKCAALVVGAGPAGVAAMGNLLARQLGAIAWVDPSFESGRVHRKYREVPSNTKVGLFQSFATAVEPFQKITEATPKPNAFTRLAKLDQEQTCKLSYAADMVRALTEGLVKMEPVNACRGFVTAAKLDSTSPSDSRWSVSVQQHSAQRPITIQTAHLVLCTGAHPTDMSLPIPDLDIARLNLDTVLKPSKLAAILPVDQAATVAVVGASHSAILALLNLVTLARESHPHLRVKWFTRHPLRYAEYKDGWILRDNTGLKGLAADFARAELEDDRLPSSPAGQVVEKIDCGGGPARENAQYEAHLPRCSHIVHAVGFTRDPLPHLTKDGNPVSMEFDHNSGRFHETDGGSVIPGLFGAGIAFPERVVDPHGNAEYAVGFFKFMKFLKRVVPSWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGA7</accession>
    <name>A0A9W9XGA7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792858.1">
        <property type="nucleotide sequence ID" value="XM_056932899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGA7"/>
    <dbReference type="GeneID" id="81623148"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02234">
        <property type="entry name" value="cupin_BLR7677-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38599">
        <property type="entry name" value="CUPIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G13620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38599:SF1">
        <property type="entry name" value="CUPIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G13620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="36"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="142" mass="15708" checksum="BF85DDCE8E72AEF7" modified="2023-11-08" version="1">MHEEPTYNPESPLGKLTICYKHKLENCAGMTVVGLIIEYPPNGATPPHRHGGAAVSAYVLRGAILNKMNEDPIELIEQGDLWHEPPGCHHRISANASQTEAASFFVTIVIETDKLGREGVSVLLQYDEEYKDIVARKMQGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGH9</accession>
    <name>A0A9W9XGH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056930910.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81621159"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36851:SF1">
        <property type="entry name" value="GLYCO_TRANS_2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36851">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="2">
        <location>
            <begin position="261"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5492561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="597" mass="67445" checksum="048C958C00EF7E66" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGI2</accession>
    <name>A0A9W9XGI2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792906.1">
        <property type="nucleotide sequence ID" value="XM_056930875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGI2"/>
    <dbReference type="GeneID" id="81621124"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="81" mass="8649" checksum="DB54841CFAEE5056" modified="2023-11-08" version="1">MPESTSSSSCNRTGCSPSSPLNSNNLSQVPQASQVTVNRFARSSAAESPYYAGARISERSKHFNGLSSQVDAVDKILKVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGS6</accession>
    <name>A0A9W9XGS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_001452</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793086.1">
        <property type="nucleotide sequence ID" value="XM_056931055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGS6"/>
    <dbReference type="GeneID" id="81621304"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000050">
        <property type="entry name" value="C6 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5492706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="705" mass="79041" checksum="F6DAFAE47E3BB5F3" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH58</accession>
    <name>A0A9W9XH58_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Manganese/iron superoxide dismutase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792920.1">
        <property type="nucleotide sequence ID" value="XM_056930889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH58"/>
    <dbReference type="GeneID" id="81621138"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="128"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="218"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5492540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="294" mass="33285" checksum="A4720E9C78BD8DE5" modified="2023-11-08" version="1">MFRRLMRPSALRAASYQTPASALRFQTRALHRIPQLQHDAYYKENGVPEFMSPEAFDFAWTQYQTLLVDKLNLLTQDTVDADAKPGELLVKYSKRPEMASVFNYASMAHNNHFFFNCLSPTTTKIPEKFAKDIVDTCSSVESLKMDFLATANAMFGPGFVWLAKNLEREGLMQIFCTYNAGSPYPAAHSRRQPVDMATHSPDAPLGNQFAGSMGAHSQNQKSLAPGAIDVQPILCVNTWEHAWMMDYGIAGKEEYLERWWDRINWDVVFDNYNAVSSVKGARNSVTRDRSLSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH59</accession>
    <name>A0A9W9XH59_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793322.1">
        <property type="nucleotide sequence ID" value="XM_056931291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH59"/>
    <dbReference type="GeneID" id="81621540"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021709">
        <property type="entry name" value="DUF3292"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694">
        <property type="entry name" value="CONSERVED EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694:SF1">
        <property type="entry name" value="PEROXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11696">
        <property type="entry name" value="DUF3292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5492942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="676" mass="73762" checksum="9C493A0AD90B821B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHM2</accession>
    <name>A0A9W9XHM2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_001928</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793562.1">
        <property type="nucleotide sequence ID" value="XM_056931531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHM2"/>
    <dbReference type="GeneID" id="81621780"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF31">
        <property type="entry name" value="MONODICTYPHENONE CLUSTER TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5493182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="450" mass="49383" checksum="D38EB529102F2F24" modified="2023-11-08" version="1">MLAESAENQRSGSDVPKLRTACENCRQSKVKCNISGKSMCTRCLRNGLQCQYGFANRSGKPKGSKNRATLRKLGELPDEKRPVRAFRATARGGSSAIRREPLLARGILDSSVNLATSESDVSARVLRLDVSCMFKLTVRKFSRSFQGCPIPGPSDIWDCPVGLANGPSLVPMSPSLMSPSLMLALSDSLLIDRDDLASPVTPSFMTFDPPELCMISPPQSDSVSSPYAPLSLCECKEMQLLNLSRLGQLLASPQSLRFDQTLQMIKMTLEVGRVFLQCQLCAKDYSNLLLLTSGLNTVLQLFECIASRETRREPQAGQDNTKYGSYEIYPGEANQIQGFLLRGSLQQCKDVLSMLVAAVKANLQARSSLLMLNWDASQEMDEAWISSDDCFPPAIKAEVEDEADIEWMSGMSSEMQHLISVLAGFQVSLDRLLQSISLGQCVCDFASILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLH7</accession>
    <name>A0A9W9XLH7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Expansin-like EG45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_000297</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794194.1">
        <property type="nucleotide sequence ID" value="XM_056929901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLH7"/>
    <dbReference type="GeneID" id="81620150"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22272">
        <property type="entry name" value="DPBB_EXLX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.760">
        <property type="entry name" value="Expansin, cellulose-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036749">
        <property type="entry name" value="Expansin_CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049818">
        <property type="entry name" value="Expansin_EXLX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041144">
        <property type="entry name" value="expansin_EXLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF21">
        <property type="entry name" value="EXPANSIN-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49590">
        <property type="entry name" value="PHL pollen allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Expansin-like EG45" evidence="3">
        <location>
            <begin position="222"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5495181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="405" mass="40858" checksum="C9650CBB14EC8861" modified="2023-11-08" version="1">MKYQGLAILFGAAATASAKHLGERHGHSQCPKGYTASVYTSYSTIYLDSTSPTATQAVAAAELTTTPSPMVVVEASTLTSTGDAYESAPTSSAAWDSAVTSSAAGIKAVITSTEDAPEPTVAVVAEMSTETVVVPAATSSASSSTSAAQVAAVNTSPASSSTTAPASAASTTSASSASSSSSAPSSSDSNSASSSPAANTHQVTSAGSSSGKATFYGGNLSGGTCSFTGYTLPQGMFGTAFSGAEWNNAAECGACVAVTGPNGKTIKAMIVDKCPECEAGHFDLFQNAFAELSALSAGIIPISWEYTPCDLSGPLSLKNKVGTSKYWFSMQVVNANEPVTKLEVSTDGGNSWKSTTRTDYNYFEQSSGFGVDSFDVRVTGQSGTTVVVKNVGPTAESVYKASANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLR7</accession>
    <name>A0A9W9XLR7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5'-3' exoribonuclease 1</fullName>
            <ecNumber evidence="6">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_000415</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794312.1">
        <property type="nucleotide sequence ID" value="XM_056930019.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81620268"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016494">
        <property type="entry name" value="5_3_exoribonuclease_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006743">
        <property type="entry name" value="Exonuclease_Xnr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="11">
        <location>
            <begin position="726"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="12">
        <location>
            <begin position="917"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="10">
        <location>
            <begin position="1156"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1237"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1237"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1339"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1381"/>
            <end position="1393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5495299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1403" mass="158370" checksum="E835B1D2BA74D64E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM70</accession>
    <name>A0A9W9XM70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Inositolphosphotransferase Aur1/Ipt1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_000674</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794571.1">
        <property type="nucleotide sequence ID" value="XM_056930278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XM70"/>
    <dbReference type="GeneID" id="81620527"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF16">
        <property type="entry name" value="INOSITOLPHOSPHOTRANSFERASE AUR1_IPT1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="155"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5495558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="307" mass="34727" checksum="CD83355FC2B447FF" modified="2023-11-08" version="1">MGSMKNILEPLAIASLHTLGAWMNRTVRHPSDVDDPSRTPLFRDDPREGRWDPGDVSTEEVASKVHNRRSNPNIPSRVLRKFPFILEIWYWLLIYWVYQGARAVSARLIAGNDATFANAERHAIQLLHLEHILNLDIELSVQQAILTKAPIYTTLPRRRYEAIRRSLALMNIFAFCIVTLWRCTPPRLLPKEYGFEDVLHKSTAGSAWTHNKFQLTIAAMPSLHFGVSVFVASCLVAFSPHTVLRSVAPIWPVMMGLTVVATANHFVLDMVVGVAVVASAYGLNRAMLILVPIERIILRILRLEKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMN1</accession>
    <name>A0A9W9XMN1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794826.1">
        <property type="nucleotide sequence ID" value="XM_056930533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMN1"/>
    <dbReference type="GeneID" id="81620782"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="161" mass="18110" checksum="30D210D7ACCF29AE" modified="2023-11-08" version="1">MSFLRRKRDAQSGAESGMEEEIVDGPDTRGEDEPDTRGKEIESQKTLLRTKGQDDRTGTLLIGEKVHISLVSLLQGAESMPRWLARNPWDTHPTLRPAVQDGDFANGAKPTMKDEKDAVGRGKQVRRREEEGDEEEEEEEEEEEEEGCGGGTRWSNKLTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN24</accession>
    <name>A0A9W9XN24_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Membrane protein TMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_001142</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795039.1">
        <property type="nucleotide sequence ID" value="XM_056930746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN24"/>
    <dbReference type="GeneID" id="81620995"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040847219" description="Membrane protein TMS1" evidence="8">
        <location>
            <begin position="18"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5496026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="52415" checksum="26458E383E4DBBC5" modified="2023-11-08" version="1">MGALLSLPLMALPSVGTLITLGGSCCGAATCSAVCSACGKFQNSMATRIAYAFILLINSIVSWIMLTPWAMKKLQHLTLDYMEITCDGKECHGWVAVHRINFGLGLFHLILALLLLGVKNTRDSRAALQNGFWGPKILFWIGFVVMSFFIPEPFFFAYGNYIAFFCAMLFLLLGLILLVDLAHTWAELCLQKIEDSDSRLWRGLLIGSTLGMYLASLVMTILMYIFFAKSGCSMNQAAITVNLIVFLIISAVSVQPAVQESNPRAGLAQAAMVTVYCTYLTLSAVSMEPDDKNCNPLIRSSGTRTVTIILGAIVTMATVAYTTTRAATQGIALGSKGGQGYIQLGEDNEHGLVTQQPNARREMRAEALRAAVESGSLPASALDESDDEDDFETTSKDDERGSTQYSYTLFHIIFFLATTWVATLLSQGITIDSNMDFVPVGRTYWASWVKIFSSWVCYAIYLWTLVAPLVLPDRFAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XPL8</accession>
    <name>A0A9W9XPL8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_001170</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795067.1">
        <property type="nucleotide sequence ID" value="XM_056930774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XPL8"/>
    <dbReference type="GeneID" id="81621023"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000670">
        <property type="entry name" value="Serine/threonin protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
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        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="50"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="525"/>
            <end position="616"/>
        </location>
    </feature>
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        <location>
            <begin position="649"/>
            <end position="783"/>
        </location>
    </feature>
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        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
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        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
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        <location>
            <begin position="663"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="739"/>
            <end position="749"/>
        </location>
    </feature>
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        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5496054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="862" mass="95239" checksum="9C77A9F86A882D95" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ28</accession>
    <name>A0A9X0BJ28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HbrB-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785736.1">
        <property type="nucleotide sequence ID" value="XM_056939014.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81629264"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Bit61/PRR5"/>
    </dbReference>
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        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428:SF2">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08539">
        <property type="entry name" value="HbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="830"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5466690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="866" mass="92609" checksum="950831DAFF9FCE0C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ95</accession>
    <name>A0A9X0BJ95_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Sterol 24-C-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_008958</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="10">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12 13">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785930.1">
        <property type="nucleotide sequence ID" value="XM_056938553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJ95"/>
    <dbReference type="GeneID" id="81628803"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000121">
        <property type="entry name" value="Sterol 24-C-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="8" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="14">
        <location>
            <begin position="81"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5469340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="377" mass="42361" checksum="DB46FD04FC4C31B7" modified="2023-11-08" version="1">MAPTALEREDVARDAAFNQAMHGKSAKARGGLTALRAKDNAAQKAAVDEYFKHWDNKGHEEETAEVREARRKEYATLTRHYYNLATDFYEYGWGSSFHFCRFAYGEPFNQAIARHEHYLAHQTGITENMKVLDVGCGVGGPAREMVKFTGAHVTGLNNNDYQIDRATHYAVKQGLSEKMAFVKGDFMQMKFPDNTFDAVYAIEATVHAPELVGVYSEIFRVLKPGGKFGVYEWLMTDEYNNEDPEHRRIRLGIEQGDGISNMVTISEGLKAMRDAGFELLHHEDLAARPDATPWYYPLAGSFKHMGSVWDFFTIARMTWWGRGIAHRFVGAGETIGLFPKGSQKTADSLALAADCLVEGAQKNLFTPMYLMVGKKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BLV1</accession>
    <name>A0A9X0BLV1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">endo-1,3(4)-beta-glucanase</fullName>
            <ecNumber evidence="4">3.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_008715</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786692.1">
        <property type="nucleotide sequence ID" value="XM_056938310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BLV1"/>
    <dbReference type="GeneID" id="81628560"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040872595" description="endo-1,3(4)-beta-glucanase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="12">
        <location>
            <begin position="26"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="317"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5472146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="367" mass="40183" checksum="74F67062FB728623" modified="2023-11-08" version="1">MRRINTTIPLLSLLARISRAAYTLHDDYETTDVFFDRFNFFTDVDPTHGYVSYMNRSAATVRGLIEAMGSSVYIGVDAEHQASGSGRQSVRLTSTRSYGHGLFILDLAHMPASVCGTWPAFWMLGADWPNDGEIDIIEGVNSQSVNQMTLHTKDGCSIQNSGFTGSLEYSNCYVGAPGQPLNSGCAILSGSPQSYGDGFNNAGGGIYATEWKSAGIKVWHFPRYGIPWNIIIGQPDPATWGTPSAAFSEYCDIDNHFKDLRIVFDITFCGDWAGNVWSSGSCASQAPTCNLFVQNNPAAFKEVFWRVNSLKVYQDNARPPLGSPSAPPGYSSVHRAIGESVSRKDATPFTRPGPRHFRHGHKGRERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BMZ1</accession>
    <name>A0A9X0BMZ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786792.1">
        <property type="nucleotide sequence ID" value="XM_056937700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BMZ1"/>
    <dbReference type="GeneID" id="81627950"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="95"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5475034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="305" mass="35293" checksum="AEFD3A7D07E5BC8D" modified="2023-11-08" version="1">MSSVPVTPTKRLTLWESPERPPKRPTPDWAAVSRFRLRPAAMGTTVKPESDFVQAARDKARREATTLQHHANINVVANQAGLDTMQVLYEMRESQKRIEAKNTHLEEELKRFEDDKIAMNKRFEAKNKHLEEELKRFEAKNKHLEEGLKRFEDERLAINNRLDSNVSRIESSETETKKQLKAVKAENAELKASVAPLQRSHFDARQRILATFVREIMLPPRGPERQQFLRTTTDDDLKRCCETIGPLIHQVHGGDVLLDADMICQRFHSEQYEYRAFEEIYGMAPGRAKNLSKFGFHLRDASFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BN20</accession>
    <name>A0A9X0BN20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable beta-glucosidase btgE</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Beta-D-glucoside glucohydrolase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Cellobiase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Gentiobiase btgE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_008307</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786999.1">
        <property type="nucleotide sequence ID" value="XM_056937907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BN20"/>
    <dbReference type="GeneID" id="81628157"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="7" id="KW-0732">Signal</keyword>
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            <begin position="67"/>
            <end position="111"/>
        </location>
    </feature>
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        <location>
            <begin position="285"/>
            <end position="314"/>
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    </feature>
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            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00039284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5475241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="575" mass="58522" checksum="6B0F0B14B18C6779" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNB9</accession>
    <name>A0A9X0BNB9_9EURO</name>
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        <recommendedName>
            <fullName evidence="8">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">N7539_007813</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
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    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MEF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="81627663"/>
    <dbReference type="Proteomes" id="UP001148312">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA binding, bending"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0033554">
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TF_MADSbox_sf"/>
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    <dbReference type="PANTHER" id="PTHR48019">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
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            <end position="61"/>
        </location>
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        <location>
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            <end position="249"/>
        </location>
    </feature>
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        <location>
            <begin position="263"/>
            <end position="608"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="161"/>
        </location>
    </feature>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <end position="438"/>
        </location>
    </feature>
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        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="482"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5475526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="608" mass="64458" checksum="B8B2D84B297CD99A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNG0</accession>
    <name>A0A9X0BNG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786925.1">
        <property type="nucleotide sequence ID" value="XM_056937833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNG0"/>
    <dbReference type="GeneID" id="81628083"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040750491" evidence="1">
        <location>
            <begin position="20"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="134" mass="14484" checksum="C95D69BDD50804FB" modified="2023-11-08" version="1">MIKGAEVEVALVVALVVAAEEVLEEDTAKVEVPAEGSVEVSEGVREAAPEKVVVQEQEQVVVQVVVQVVVQVVVQVVVQVVVQEQEQVVVQEQEQVVVQVVVQEQEQEKEAAAVVVKVVAWAATAQNEEPEERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNP1</accession>
    <name>A0A9X0BNP1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">BCAS2 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_007268</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPF27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787668.1">
        <property type="nucleotide sequence ID" value="XM_056936869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNP1"/>
    <dbReference type="GeneID" id="81627118"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        </source>
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        </source>
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</entry>
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    <name>A0A9X0BSM4_9EURO</name>
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    </evidence>
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    </evidence>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="25"/>
            <end position="36"/>
        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5482767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="62980" checksum="0BE98A3719D86787" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BTZ3</accession>
    <name>A0A9X0BTZ3_9EURO</name>
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        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">N7539_005913</name>
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    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789387.1">
        <property type="nucleotide sequence ID" value="XM_056935515.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81625764"/>
    <dbReference type="Proteomes" id="UP001148312">
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    </dbReference>
    <dbReference type="GO" id="GO:0070692">
        <property type="term" value="C:CTDK-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032786">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CTD kinase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042326">
        <property type="entry name" value="Ctk3"/>
    </dbReference>
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        <property type="entry name" value="Ctk3_C"/>
    </dbReference>
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        <property type="entry name" value="Ctk3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291:SF1">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF12243">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CTK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5484117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="245" mass="28131" checksum="293A403861F9F491" modified="2023-11-08" version="1">MVDPFEVRMRFTQQLQHLSASVTSSQKAAQYALKHRDWDEDLHSCILEQLERNNMNNRANIMSFIEQFCDMATKENHLPYVRMMQRDILRVVDAVVPPDGSGAANVKHVRHVLETLRARGMLSAESVAEIDAALKDRDANGEHYDLEDEEKARGGNGTLSRSGSPRHVRPPDMRLDKRQIEQRIEEDRERNKRLRESMWTVGGGEKDELQKTKDDLSDLDSDDFDNTEEEKSERDHASAGMRGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUD2</accession>
    <name>A0A9X0BUD2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S ribosome biogenesis protein Mak11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="81624892"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5485053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="53984" checksum="109A7FA29D253561" modified="2023-11-08" version="1">MVKRKRNESIKEEAVTAGSSTKTAKSAATPSETPDAAVTVQVVTGSYERVLHGFTAGIPVSAFLNERGSSKNDENSIQCVDSFLFEAHGSAIRCLALSPLPKPTDSPDAQKVFLASGSTDERIQLYSLAAAPLAVNDEYPSVPTLAGNKILENPKNRELGSLLHHSASITALSFPSRSKLLAAAEDNEISISKTRDWSVISTIKAPHPKVQGRPSGDTAPPGAAPSGVNHFAVHPSMKLMLSVGKGEKCMRLWNLVTGKKAGVLNFGREILQSVKEGKYSSGEGRRLAWNTAGEEFAVAFEWGAVVFGIDSTPKCRVLPSPRSKIHEMKYVSVAGDGQETNDLLAVSTEDGRVVFYSTTTLQEPEDSDESTISHATAVTQIGGKQAGFPGRIKDFEVLNLNNQAANISQNLLVVTGNSDGVVRIWTVNRKSLAPTKSVKAVKAATETVRQAGSLLTTYETGNRITCLAAFVMLPAEDVSTLFDSADEESEEEEEEESDSDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUK4</accession>
    <name>A0A9X0BUK4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor of morphogenesis MCM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_004728</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
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    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056934330.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81624579"/>
    <dbReference type="Proteomes" id="UP001148312">
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="50"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5484740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="215" mass="23908" checksum="295240EDB4C8D9DD" modified="2023-11-08" version="1">MADMAAVDEKLSPNQHDELQQPGNGTDARGTKRNRMSAEDDDDDDDKPGRERRKIEIKFIQDKSRRHITFSKRKAGIMKKAYELSVLTGTQVLLLVVSETGLVYTFTTPKLQPLVTKPEGKNLIQACLNAPDPTTNENGVDTGDVPAETPEDVGHNVNAPQPNMARPGMHPGYMTNEQQQQMAYYQNLQQQQQATAQYPGMPVGNRMPPQHQPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUN3</accession>
    <name>A0A9X0BUN3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_005029</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789825.1">
        <property type="nucleotide sequence ID" value="XM_056934631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUN3"/>
    <dbReference type="GeneID" id="81624880"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16568">
        <property type="entry name" value="RING-HC_ScPSH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15898">
        <property type="entry name" value="BIFUNCTIONAL APOPTOSIS REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15898:SF13">
        <property type="entry name" value="BIFUNCTIONAL APOPTOSIS REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="31"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="302"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5485041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="533" mass="60572" checksum="1B69C8EA4BE0CB5B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUY4</accession>
    <name>A0A9X0BUY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enolase C-terminal domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_005088</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789884.1">
        <property type="nucleotide sequence ID" value="XM_056934690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUY4"/>
    <dbReference type="GeneID" id="81624939"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050023">
        <property type="term" value="F:L-fuconate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03324">
        <property type="entry name" value="rTSbeta_L-fuconate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000007">
        <property type="entry name" value="Mitochondrial enolase superfamily member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034610">
        <property type="entry name" value="L-fuconate_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00111">
        <property type="entry name" value="L-fuconate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00270">
        <property type="entry name" value="L-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="198"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5485100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="452" mass="50088" checksum="A80E6AED668D0637" modified="2023-11-08" version="1">MVKITGFTTRDVRFPTSLDKTGSDAMNAAGDYSAAYCILSTDSEFQGHGMTFTIGRGNEIVCAAISLVAPLIEGKELDELTADWGKTWRYLVSDSQLRWIGPEKGVIHLALGAVVNALWDLWAKTLGKPVWRIVADMTPEEFVRCIDFRYITDAITPEEALSMLKEIEAGKQDRIKEAEASQAVPAYTTSAGWLGYSEEKLKKLLEESVAQGYKHFKLKVGANVEDDKRRLRIAREAIGYDKGNILMVDANQVWSVPEAITWMNELAEFKPWFIEEPTSPDDILGHAAIRKALSNTPHGAIGVATGEMCQNRVVFKQLLQAGALTVLQADACRVGGVNEVLAILLLARKFNVPIVPHSGGVGLPEYTQHLSTIDYVVVSGKKSVLEYVDHLHEHFVHPSSVKDGYYVTPMEPGYSVEMKPESMDQFAYPGEEGKSWWRSQEARVILDGPRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY14</accession>
    <name>A0A9X0BY14_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UNC-45/Cro1/She4 central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_003798</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="UCS_central_dom"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="UNC-45/Cro1/She4 central" evidence="5">
        <location>
            <begin position="225"/>
            <end position="376"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF11701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5488908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="839" mass="90592" checksum="1654006F11BF00FB" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY62</accession>
    <name>A0A9X0BY62_9EURO</name>
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        </submittedName>
    </protein>
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    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5488877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="81623618"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5488877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="69" mass="7845" checksum="39373B433DCD08EF" modified="2023-11-08" version="1">MLFAAWLAASTCLGNRLRNERDSGRQYFGAYGQSYLRTMANSGPAMSEQIELDDMLAEPGTRRDFQEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYE0</accession>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        </lineage>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">IBT 30728</strain>
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    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="1490"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="5">
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            <begin position="1703"/>
            <end position="1921"/>
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    </feature>
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            <end position="2240"/>
        </location>
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        </location>
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            <end position="2451"/>
        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF07539"/>
        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23099"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="2637" mass="298054" checksum="F10DECD87575C166" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYE1</accession>
    <name>A0A9X0BYE1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">IBT 30728</strain>
        </source>
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                <person name="Frisvad J.C."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056934253.1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="111" mass="12244" checksum="621F45A4E748DBDE" modified="2023-11-08" version="1">MATRASLAVEELAHDRSAVEQYCYHVTHSQDGLSTIIGAGQKHAATVQGGFYLRGDVPAAVNFEIHNKQKDGIHTPNQADYETYLWKMADSNSECYGSKEQEPWPGCSISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYS1</accession>
    <name>A0A9X0BYS1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">asparagine--tRNA ligase</fullName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_004412</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791555.1">
        <property type="nucleotide sequence ID" value="XM_056934014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYS1"/>
    <dbReference type="GeneID" id="81624263"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1910.20">
        <property type="entry name" value="asparaginyl-tRNA synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048952">
        <property type="entry name" value="AsnRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20917">
        <property type="entry name" value="AsnRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="327"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5489522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="557" mass="63145" checksum="E70564ACCFB1BBED" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ67</accession>
    <name>A0A9X0BZ67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_002530</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792092.1">
        <property type="nucleotide sequence ID" value="XM_056932133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ67"/>
    <dbReference type="GeneID" id="81622382"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF25">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="10">
        <location>
            <begin position="32"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="9">
        <location>
            <begin position="198"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5490963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="42265" checksum="4DE92683BA87B3A1" modified="2023-11-08" version="1">MSTETSATALVLHGAKDLRLETRTVPAPTGADLQVAVTATGLCGSDLHYYSHGRNGDFVVREPMCLGHESAGVVTAVGPEVGAGFKVGDRVALEVGLPCRQCAFCKNGRYNICKKMRFRSSAKTFPHLDGTLMARTNHPAAMCHALPDTVSDAGGALVEPLAVCLHAIRRSHPPTKEEVALSNAAGEGTAALVFGAGAIGLLVASALAVSENFESIVVADIDASRLEIAASLGLGLKTALIPRADPSSPAPPPKDAPHAEQIAWALTNAQGVAASLVQAAQKDGMPPVSGFSRVYDCTGVPACVQAGIYASEPGGVLVQIGMGNPIQTLPVGAAALREVDIIGVFRYDGYAYPAAISLLGSGKLKTTEEKVVTHRLPLEEGERAFILAGKGVDEDGRPVVKVVIENKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ70</accession>
    <name>A0A9X0BZ70_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">High-affinity fructose transporter ght6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_002439</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792001.1">
        <property type="nucleotide sequence ID" value="XM_056932042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ70"/>
    <dbReference type="GeneID" id="81622291"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF39">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="52"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="534"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5490872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="573" mass="63384" checksum="47A2F9A7D9AF80AD" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZD4</accession>
    <name>A0A9X0BZD4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792808.1">
        <property type="nucleotide sequence ID" value="XM_056932849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZD4"/>
    <dbReference type="GeneID" id="81623098"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="89"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="395" mass="44678" checksum="D375499CB74566BD" modified="2023-11-08" version="1">MSTESSSWTTVQDFLRDSDSQTAHCFRQTRWDELCRIASGLAGHLDCIALDQVTSGLNNIVRMLEFSDQTRWVARVHIRRSNSPLTDWTKLNTEISTMQFIKENSDIPVPRVFAYKADENHSVNAAFMLIELLPGIVAMDALGGYKVHRGVIPRDRRQNFYRSVAKSHVQLTSLRLPKIGTIVKNNKGGYECGPLPGIGGPFDTAAAFFEAWANNVKFKWDKETITRMMQGGPILAERMIAIIDNFPSQIKAMASQLSLCNEGPFPLNHDDFLHSNIIVDEKSFDVTGIIDWEGACTVPWELIAFPDFLRAMPISFDLPQNYGQDGQPLDEELQETWREREEYIEMAKSAELEDNLLSSYLSSKRSQAISYLYGAYTSVGKLGTYDRVLEELELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C047</accession>
    <name>A0A9X0C047_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_001834</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793468.1">
        <property type="nucleotide sequence ID" value="XM_056931437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C047"/>
    <dbReference type="GeneID" id="81621686"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000095">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF365">
        <property type="entry name" value="ENDOCHITINASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="5"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5493088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="400" mass="44163" checksum="88264305EEC7C4FF" modified="2023-11-08" version="1">MSAGLKTIAYFVNWAIYGRNYNPQDLPAEKLTHVLYSFANVHPETGEVYLTDTWSDIEKHYEGDSWNDTGTNVYGCIKQLFLLKKKHRQLKVLLSIGGWTYSANFAVPASTPAGRARFAESATRLVLDLGLDGLDIDWEYPQDASQATNLVELLQACRQRLDAAAGSHRKFYLSIACPAGPSNFEKLKLHDMNPLLDFYNLMAYDYAGSWDRVAGHQCNIYPSKSNPASTPFSTIAALEYYMNVGGVPAQKLIMGMPLYGRAFENTNGPGQPYSGVGPGSWENGVWDYKALPRPGAEEHLDTEADASWSYDPKSRTMVSYDTVEMCQRKAAFVRYRQLGGGMWWESSGDKGGKEADPGQGSLIGTFVNGIGGTSVLDGIENALEYPESKYDNLRAGFPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C086</accession>
    <name>A0A9X0C086_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyl hydrolase family 95 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_001954</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793588.1">
        <property type="nucleotide sequence ID" value="XM_056931557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C086"/>
    <dbReference type="GeneID" id="81621806"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000028">
        <property type="entry name" value="Alpha-L-fucosidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049053">
        <property type="entry name" value="AFCA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016518">
        <property type="entry name" value="Alpha-L-fucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054363">
        <property type="entry name" value="GH95_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084:SF18">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 95 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21307">
        <property type="entry name" value="Glyco_hydro_95_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22124">
        <property type="entry name" value="Glyco_hydro_95_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007663">
        <property type="entry name" value="UCP007663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 95 N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 95 catalytic" evidence="3">
        <location>
            <begin position="264"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha fucosidase A-like C-terminal" evidence="2">
        <location>
            <begin position="666"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5493208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="751" mass="84441" checksum="6DD7A9C133D53829" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0A3</accession>
    <name>A0A9X0C0A3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002118</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793752.1">
        <property type="nucleotide sequence ID" value="XM_056931721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0A3"/>
    <dbReference type="GeneID" id="81621970"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000003">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000005">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5493372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="366" mass="42171" checksum="C82ECD9EBA71FE8E" modified="2023-11-08" version="1" fragment="single">CLPQTTQPTRCRDPALSCIDLPIMLLLDYQNALIQSLLTERFSGAPPVSIDQVVSDFDGVTFHLSTPESKTKILISINVKCFKELVQYGAQEVLEREYGPYIVSPEPGYDFSVQVDLENLPAEQEAKDELIMKLALLKRNAMAAPFERAFDEFAKLEEEASRYTSESAPQGVQEGGEVMAIHYREEEAIYIKASYDRVTVIFSTVFREETDRIFGKVFLQEFVDARRRVVTLQNAPQVLFRSDPPLELQGLPGHENAVKGEMSYVTFVLFPRHLTPQRRYENISHIQTFRDYFHYHIKASKVRQADTTTLESHNIRPDADTKRQAYIHTRMRKRTADFLQVLNRARPENEDRERKTASGRTFRVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0D9</accession>
    <name>A0A9X0C0D9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793857.1">
        <property type="nucleotide sequence ID" value="XM_056931826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0D9"/>
    <dbReference type="GeneID" id="81622075"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="155" mass="17258" checksum="A1E75D1046DCE76C" modified="2023-11-08" version="1">MARPTGLSPLALVTLDQTDFELPSTSVFGNAAIIHSLLRGLTLTTLEIWSKGLSFIAIGRYCDRANRTYRSSKETDGERHLAPVLPPEAWLDYQVVAGRKLTCSVHLGRIAIQDGASVFRSRPDSERFTQVEEDERPHAKGAHERLNDDVTITRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0M5</accession>
    <name>A0A9X0C0M5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Arginase</fullName>
            <ecNumber evidence="2 11">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_001880</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793514.1">
        <property type="nucleotide sequence ID" value="XM_056931483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0M5"/>
    <dbReference type="GeneID" id="81621732"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000009">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5493134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="324" mass="35660" checksum="386CB8C9DE214E34" modified="2023-11-08" version="1">MTQPPTFPSRFLSHPNQLGVVAVGFNGGQMKKGVEAAPMALIESGLLTQLHEDLDYEIHHDNIIHYYEQDIPEEDPDHRNMKKPRAVSAVTERLSSQVYEYAKEGKFVLTLGGDHSIAIGTVSGTAKAIRERLGREMAVIWVDAHADINLPEMSPSGNIHGMPMAFLTRLAREDRPDIFGWLKDEHIVSTRKLVYIGLRDVDRGEKKILREHGIKAFSMHDIDRHGIGRVVEMALAHIGNDTPIHLSFDVDALDPQWAPSTGTPVRGGLTLREGDFICECVHETGNLVAMDLVEVNPSLEAVGAAETIRAGCSLVRSALGDTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0X2</accession>
    <name>A0A9X0C0X2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_002165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793799.1">
        <property type="nucleotide sequence ID" value="XM_056931768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0X2"/>
    <dbReference type="GeneID" id="81622017"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000072">
        <property type="entry name" value="AT09463p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052562">
        <property type="entry name" value="Ketohexokinase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774:SF3">
        <property type="entry name" value="KETOHEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774">
        <property type="entry name" value="PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5493419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="314" mass="34482" checksum="2173D2390D1A1248" modified="2023-11-08" version="1">MLVAIGACYFDTVLTTSHYPAEDEKLRASSVTRRRGGNCPNTLEVLGQLVSEDDIEHEFPLELITVLPARSSQASQRIISEFSPRVGLENCVYREDHKEPASCYIIRSKATGSRTIVNYNNLPEATQEELIERIDLLSPRASWFHFEGRMPDLTLKSIRYIRKHLPATKISVEMERPGRPGLQALAQEADVVFYARSWALGAGHSTAEECLHAEAALTPTASLLCCTSGEEGASALQPSDGTFAHAPAHTTENFQVVDPIGAGDTFIAGMLYSLARRDPDWDLTQKLAFANRLAGTKVSQEGFSGLYRVLASIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C1Z1</accession>
    <name>A0A9X0C1Z1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_000214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794111.1">
        <property type="nucleotide sequence ID" value="XM_056929818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C1Z1"/>
    <dbReference type="GeneID" id="81620067"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF3">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="628"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="657"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="683"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="732"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="3">
        <location>
            <begin position="34"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5495098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="755" mass="81854" checksum="359FF8433CC47799" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2D3</accession>
    <name>A0A9X0C2D3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit WBP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_000487</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794384.1">
        <property type="nucleotide sequence ID" value="XM_056930091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2D3"/>
    <dbReference type="GeneID" id="81620340"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041016569" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1" evidence="8">
        <location>
            <begin position="19"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="307"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5495371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="459" mass="50967" checksum="9CD76AB130E3E0EC" modified="2023-11-08" version="1">MRWCLALLLCGFLAAVNALSSSGSRLLVVLDESTDQSAYSTLWSDLKGRGYDVSFESPKSDKLSLFKHGARAYDHLLILPPKSKGLGPSLTPKNILDFLNKDGNILLALSGRAATSSAISSLLLEVDIQLSNDRSSVVVDHFNYDTVSSAEKHDVLLLQRPGPLRPDVKAFFNGEGVVALPRVAPQTLGSESNLVSPILRAPATAYAYNPKEEMPAPEDIEATGSQLNIVSAMQARNSARFTVLGSVEALEDQWFSASVQAPGGKKTTTVNREFAKQLTAWAFKETGVLKVEKIEHHLATDGEVAPENLNPKIYRIKNETVFNIEVSEYSYDKWVPFEVPGNDELQLEFTMLSPFHRLALKPVGRTETSTIYSTKFTTPDQHGIFSFRINYKRPFFTNIEEKHEVTVRHFAHDEYPRSWDISAGWVWIAGLWSVIGGFLAFVLVWLYSAPATDKLKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2N0</accession>
    <name>A0A9X0C2N0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-dependent kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_000888</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a key role in the control of the eukaryotic cell cycle. Required for entry into S-phase and mitosis. Acts as a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. May function in concert with npp-16 to arrest prophase blastomeres in response to anoxia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with cks-1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794785.1">
        <property type="nucleotide sequence ID" value="XM_056930492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2N0"/>
    <dbReference type="GeneID" id="81620741"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07835">
        <property type="entry name" value="STKc_CDK1_CdkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000706">
        <property type="entry name" value="Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000027">
        <property type="entry name" value="Putative Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="16"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5495772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="337" mass="37845" checksum="B0151F239ED19625" modified="2023-11-08" version="1">MAWGSQPSGGASMENYQKIEKIGEGTYGVVYKARELNHPNRIVALKKIRLEAEDEGVPSTAIREISILKEMQDPNIVELLNIVHADGHKLYLVCEFLDLDLKKYMEALPVSEGGRGKALPEGSMMSANLGLGEAMVKKFMAQLVEGIRYCHSHRILHRDLKPQNLLIDRHGNLKLADFGLARAFGVPLRTYTHEVVTLWYRSPEILLGGRQYSTGVDMWSVGAIFAEMCTRKPLFPGDSEIDEIFKIFRILGTPDEVEWPGVTSFPDYKPTFPKWKRPDTPIVPGLEENGEALLEALLEYDPAHRLSAKQACMHPYFKNGSSYYSGRTVSTTRNGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2P0</accession>
    <name>A0A9X0C2P0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor spt8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_000471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794368.1">
        <property type="nucleotide sequence ID" value="XM_056930075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2P0"/>
    <dbReference type="GeneID" id="81620324"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000789">
        <property type="entry name" value="Transcription factor (SPT8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000927">
        <property type="entry name" value="Transcription factor (SPT8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057544">
        <property type="entry name" value="Beta-prop_SPT8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23798">
        <property type="entry name" value="Beta-prop_SPT8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="3">
        <location>
            <begin position="117"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="237"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="3">
        <location>
            <begin position="482"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="408"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5495355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="651" mass="70185" checksum="FA89CAEF6CE780D9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2V1</accession>
    <name>A0A9X0C2V1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biogenesis of lysosome-related organelles complex 1 subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_001144</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795041.1">
        <property type="nucleotide sequence ID" value="XM_056930748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2V1"/>
    <dbReference type="GeneID" id="81620997"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009395">
        <property type="entry name" value="BLOC1S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073:SF0">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073">
        <property type="entry name" value="BLOC-1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06320">
        <property type="entry name" value="GCN5L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="122"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5496028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="196" mass="22184" checksum="17D9C2FCFF48C8D1" modified="2023-11-08" version="1">MDTNMTDYAPSTTHLPDSTEDHQKQEALAAFTATLRSVGTNLEAPLRDRAAIITANEAALQRQEAELVEHTAQLARQNAQWTGWAEETREGLKEIGDVQNWAEMIERDLLILEDMMDGVEMRENEEDEGDDDDREHRGQRGVSEEDEQMGMDEILRLGVAGDEDGPVQNGNGLWQGKGKKADDRKSSRFWLRWWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C328</accession>
    <name>A0A9X0C328_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">beta-glucosidase</fullName>
            <ecNumber evidence="11">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_000800</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="11"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794697.1">
        <property type="nucleotide sequence ID" value="XM_056930404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C328"/>
    <dbReference type="GeneID" id="81620653"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
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    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="9 11" id="KW-0624">Polysaccharide degradation</keyword>
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            <end position="19"/>
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            <begin position="20"/>
            <end position="873"/>
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            <end position="857"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5495684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="873" mass="93298" checksum="40411A7987258E1C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9X0C347_9EURO</name>
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        <submittedName>
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        </submittedName>
    </protein>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillaceae</taxon>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="81620713"/>
    <dbReference type="Proteomes" id="UP001148312">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="50" mass="5488" checksum="FFF0DBAEE89D351B" modified="2023-11-08" version="1">MQRNITIVVILILIFILIFIGALIAYAMKHQLGPFAGKRVSDEESEGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
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        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">N7539_001026</name>
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        <name type="scientific">Penicillium diatomitis</name>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5495910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056930630.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="3">
        <location>
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            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5495910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="589" mass="67785" checksum="2B52DB82BB7AD920" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WK57</accession>
    <name>A0A9W9WK57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-L-arabinofuranosidase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_009505</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="10"/>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785595.1">
        <property type="nucleotide sequence ID" value="XM_056939100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WK57"/>
    <dbReference type="GeneID" id="81629350"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23399">
        <property type="entry name" value="beta-trefoil_ABD_ABFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000131">
        <property type="entry name" value="Probable alpha-L-arabinofuranosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000059">
        <property type="entry name" value="Probable alpha-L-arabinofuranosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015289">
        <property type="entry name" value="A-L-arabinofuranosidase_B_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038964">
        <property type="entry name" value="ABFB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007934">
        <property type="entry name" value="AbfB_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036195">
        <property type="entry name" value="AbfB_ABD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39447">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39447:SF2">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05270">
        <property type="entry name" value="AbfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09206">
        <property type="entry name" value="ArabFuran-catal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110221">
        <property type="entry name" value="AbfB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041015087" description="Alpha-L-arabinofuranosidase" evidence="10">
        <location>
            <begin position="27"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase B catalytic" evidence="12">
        <location>
            <begin position="28"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase B arabinose-binding" evidence="11">
        <location>
            <begin position="360"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="89"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="184"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="409"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR638964-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR638964-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5466549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="506" mass="52745" checksum="1F71BEBB27FD99E8" modified="2023-11-08" version="1">MLSGWSREQVWALAWGLVVNGSLVFAGPCDIYSAGGTPCVAAHGTTRALYSSYSGALYQVKRASDGATTDIAPLSAGGVANAAAQDKFCASTTCVISVIYDQSGHGNHLTQAPPGAFKGPDVNGFDNLASAIGAPVTLNGQKAYGVFISPGTGYRNNNAKNTAVRDEPEGMYAVLDGTHYNGGCCFDYGNAETSSTDTGNGHMEAIYFGDNTGWGSGAGSGPWVMADLENGLFSGRNVKQNTGDPSINYRFLSSIVKGEPNQWAIRGGNAASGSLSTFYSGPRPNASGYNPMSKEGAIILGIGGDNSVSGQGTFYEGVMTSGYPSDATENAVQANIVAARYAVAPLSTGPALSVGSSISLRATTPSYTDRYIAHTGSTVNTQVVSSSSSTSLKQQATWKVRTGLANSECYSFESVDSPGSFIRHYNFALLLNANDGTKIFGEDATFCTQPGLNGQGDTLRSWSYPTRSFRHFNNVLYVASNGGVQDFDATASFNNDVSWVVGAGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKD0</accession>
    <name>A0A9W9WKD0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_009566</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785656.1">
        <property type="nucleotide sequence ID" value="XM_056939161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKD0"/>
    <dbReference type="GeneID" id="81629411"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5466610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="174" mass="17847" checksum="40F62FD643F4DDA3" modified="2023-11-08" version="1">MSFPGATPGMGGLGGNQTAGMSEQEQAMVKMMQAGMESCPVKTVIAGGMGFALGGAFGLFMASMSYDSPLTPQGREISHLPWREQVRRGFKDMGSRSFSSAKNFGIVGALYSGTECCIEGLRAKNDLTNSVAAGCLTGGILGAKAGPQAAAFGCAGFAAFSAAIDAYMRMPSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKV6</accession>
    <name>A0A9W9WKV6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_009538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785628.1">
        <property type="nucleotide sequence ID" value="XM_056939133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKV6"/>
    <dbReference type="GeneID" id="81629383"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000045">
        <property type="entry name" value="Aldo-keto reductase (AKR), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="35"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5466582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="315" mass="35050" checksum="64CDE3328BADB2ED" modified="2023-11-08" version="1">MTRSIQKVWDKYTLLAVGTSVPTVLPVFIYGTAWKKERTAGLVYDAITAGFRAIDTAAQPRHYQEHLVGEGIQRVIAEGIVRREDLYIQTKFSPIAAQDPENMPYNAEASVTEQVHASVKSSLYNLRPSPDPRTTTDTYIDTVVIHSPLQTPEETQEAWQALECYVPRYIRNLGISNCSVPVLRALFNAATVKPATVQNRFYPATSYDSELRGFCLENQIIYQSFWTLTANPTLVRSRPVQQLAAQVGISAPAALYTLVMALGNTSVLNGTTNKARMNEDLAAPLAVSEFIQKRPELWARLSGDFQEIVGAYQSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKZ9</accession>
    <name>A0A9W9WKZ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="12">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_009386</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785703.1">
        <property type="nucleotide sequence ID" value="XM_056938981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKZ9"/>
    <dbReference type="GeneID" id="81629231"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000031">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12 14" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5466657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="87" mass="10013" checksum="00C2BB8E1C6FF928" modified="2023-11-08" version="1">MAPRKTLLAPIHFIFSLLQKRSTVSIWLYEQLAFRIEGKIRGFDEFMNLVVDDAVEVRLATKTEEEKRRPLGQILLKGDNVSLIQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL69</accession>
    <name>A0A9W9WL69_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Pectinesterase</fullName>
            <ecNumber evidence="4 12">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_009099</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in maceration and soft-rotting of plant tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pectinesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="4 12"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786071.1">
        <property type="nucleotide sequence ID" value="XM_056938694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL69"/>
    <dbReference type="GeneID" id="81628944"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000014">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018040">
        <property type="entry name" value="Pectinesterase_Tyr_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF127">
        <property type="entry name" value="PECTINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00800">
        <property type="entry name" value="PECTINESTERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="9 12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040756464" description="Pectinesterase" evidence="13">
        <location>
            <begin position="16"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="14">
        <location>
            <begin position="26"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5469481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="327" mass="34185" checksum="CD5DA4A8EF0F27A1" modified="2023-11-08" version="1">MRLFTLLSLAATVLAGSRTTAPAGAIVVAKSGGQYSTISQAIAALSSTTTSTQTIFIKAGTYDEQVYIPSLAGELIVYGQTADDTSYSSNTVTITHAISLASASNDDHTATLRNYAAKSRIYNINVKNTYGQGHQALALSAYNTQQGYYGCQFIGFQDTVLAETGYQVYAKCYIEGAVDFIFGQTGNAWFDDCTIGVVAYSSGTITAQGRPSSSSSGYFVINGGSVKAASGQTVAAASYALGRPWTEYARVVFQKTNLSSVIKAAGWDTWSSSSPNTAGVLFGEYENTGAGASGTRASFAEKLSAAVSISSILGSGYTSWVDTSYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLR8</accession>
    <name>A0A9W9WLR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Condensin complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_009076</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CND1 (condensin subunit 1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786048.1">
        <property type="nucleotide sequence ID" value="XM_056938671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLR8"/>
    <dbReference type="GeneID" id="81628921"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000272">
        <property type="entry name" value="Condensin complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000920">
        <property type="entry name" value="Condensin complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12922">
        <property type="entry name" value="Cnd1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017127">
        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="13">
        <location>
            <begin position="87"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="12">
        <location>
            <begin position="1003"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="821"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1185"/>
            <end position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5469458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1210" mass="134815" checksum="D2E6F83BD84D2786" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLS7</accession>
    <name>A0A9W9WLS7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SURP motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_009150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786122.1">
        <property type="nucleotide sequence ID" value="XM_056938745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLS7"/>
    <dbReference type="GeneID" id="81628995"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000015">
        <property type="entry name" value="Splicing factor 3A subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="31"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="130"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="315"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="451"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5469532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="522" mass="58650" checksum="651B187D187CB504" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQU0</accession>
    <name>A0A9W9WQU0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786536.1">
        <property type="nucleotide sequence ID" value="XM_056938154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQU0"/>
    <dbReference type="GeneID" id="81628404"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="52349" checksum="8243172AD5C6614E" modified="2023-11-08" version="1">MEAPESAQRKKPRYNNEQGRSQERRKRKRGVEDPPKYPHWGEVGLRPFLGVREGQTDELGASEMYRFVCRLDGAARWAMTFEQMKADLIRDLTEAPKFGRLIAQSKIPRLLPLRQPDVILVDDETLEGWLRKKFPMPLLYRAEIGGKSPALKGMTWERFWKAQLDEVPDATVGVYDYSHPDPQDRITDWSVRQIHEYWKRPAGERGAINVLDLENADGDFCPIAIVSQDVAQKALRRKLRTAGRSDSRWESHRKEFFLLSAANAVSAIHVDNGGLLTWAFAEAGAQYVEACKDDGWVKVELKMGDILIMPPSWPHAVFTPEDCLAVGGHFYTVSHLGSTLAGLSRQERYPEMCNESLEPATYETLAVIFDCGLYDANDHVGILSTAGSFVHNWDLMSQARAIEAAGIDSPKDDPREHILAHRDHLVKPYSADVLEKPIDARGRLANALARVRERMRQAIDALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WR08</accession>
    <name>A0A9W9WR08_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_008659</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786636.1">
        <property type="nucleotide sequence ID" value="XM_056938254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WR08"/>
    <dbReference type="GeneID" id="81628504"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5472090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="118" mass="13622" checksum="178010AC4B46B341" modified="2023-11-08" version="1">MNNSQTWDLFHKGHLFYARDSRKKNSDSHHIAEMIALLGPPPKEMIQSSEYAAEFFDGEGNWKGVVPIPSLTLEQLEGNLHGAQQKLFLEFMRKMLQWRPEERASAKDLLSDPWLKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WT34</accession>
    <name>A0A9W9WT34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucan endo-1-3-alpha-glucosidase agn1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786765.1">
        <property type="nucleotide sequence ID" value="XM_056937673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WT34"/>
    <dbReference type="GeneID" id="81627923"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5475007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="121" mass="13443" checksum="701EAD98826B34B2" modified="2023-11-08" version="1">MRRAREAGIDVFAMNIGTDSFTDKQLGFAYESAANNEMKLFLSFDFNYWGIGQGNEIGAKLRLDGKVFVSSFVGDGVNVESIRLAVGLDIFFALNFYTDVGDFNIIDGVFNWMAWPSNGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTG0</accession>
    <name>A0A9W9WTG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786960.1">
        <property type="nucleotide sequence ID" value="XM_056937868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTG0"/>
    <dbReference type="GeneID" id="81628118"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="52"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="237" mass="26621" checksum="55DD96B29D7D5B75" modified="2023-11-08" version="1">MYLQLHAYACGAFKRAAGHEMGQAWKEISGLHRKVLSIFAANSFKDVFWLGSRINHSCLPNVAFSYNPAIKHGTFHAIRDLAAGEELTVEYISDDKLAQPTIYNDSKSNEEARGLSLRMAAMQKSEGLVGPELSETYHKVASYSMRMMELQMALLWAEKVVEVDRYCVGEDHPDFVQTREIVEKIRQTARESVPFDKLALRWLFRPTEPTEPGFRNPALLIAAFASLCRLPGGPAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTR6</accession>
    <name>A0A9W9WTR6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787097.1">
        <property type="nucleotide sequence ID" value="XM_056938005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTR6"/>
    <dbReference type="GeneID" id="81628255"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5475339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="34356" checksum="A653019A0FF0C39A" modified="2023-11-08" version="1">MVLHYHNECIGDLRYLASEPNAIMDEELLAAVVILRFYEELDSPFIEFSTETAVTGLQVFIEAQANLALASLGFRQAVFWVGFRQEFHIAFAQQRPFCLPLSACESFLTWDPAPDHVWVNRLLIICAHAVQYCHDDTLNQNATRYQGLIDLYNRWQQCRPISFSPIYAVDADQTQREIFPRVRYLDDCHILALQSIGLLKILLTAYSPHVPRVGPARRKSLAQVDAKLRATVLEICGVALSNRQSPPALITACVSINTCCEQFSDLTEQQALMEINSITTQETNYWPTSVSKAKLEEVWGWGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTZ9</accession>
    <name>A0A9W9WTZ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA damage response protein kinase DUN1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_008138</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786830.1">
        <property type="nucleotide sequence ID" value="XM_056937738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTZ9"/>
    <dbReference type="GeneID" id="81627988"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001380">
        <property type="entry name" value="Checkpoint kinase 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000841">
        <property type="entry name" value="Checkpoint kinase 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF30">
        <property type="entry name" value="PHOSPHORYLASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="179"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="270"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="598"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5475072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="640" mass="72361" checksum="B849A24C84142A40" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU27</accession>
    <name>A0A9W9WU27_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multiprotein-bridging factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_007807</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
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</entry>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26818" checksum="4120D87EE3EFED1A" modified="2023-11-08" version="1">MGEFQDAVPKLKGVSNFRNWQTSLEHYLNYRNPGMWAVMTGAHVPETNNPLPTPGEEEVRLHISAEHDITPEDVTSSQIREWLQVNILQKNEEFATWHKLNAGCLFYLSASLAESIKACIRKFKVASEAYEEICSFWKLESSLAFPERYRKWVTCHYRQGGKARVFVHKWKKCLQEVQEVSPDLLPPAWQYGQFLQAIRSHPEAELLVTHHKPDLESPRILQDVISKFLSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUN2</accession>
    <name>A0A9W9WUN2_9EURO</name>
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        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
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    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAJ5475613.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1186" mass="129997" checksum="5E386D4C881AFCCE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUP1</accession>
    <name>A0A9W9WUP1_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056937305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUP1"/>
    <dbReference type="GeneID" id="81627554"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022198">
        <property type="entry name" value="DUF3723"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12520">
        <property type="entry name" value="DUF3723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="633" mass="71875" checksum="A20C6D1050B10E94" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUT9</accession>
    <name>A0A9W9WUT9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromatin structure-remodeling complex subunit rsc7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_007273</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787673.1">
        <property type="nucleotide sequence ID" value="XM_056936874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUT9"/>
    <dbReference type="GeneID" id="81627123"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF3">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5477129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="573" mass="63439" checksum="5F7784046E37B396" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVG2</accession>
    <name>A0A9W9WVG2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_007592</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787992.1">
        <property type="nucleotide sequence ID" value="XM_056937193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVG2"/>
    <dbReference type="GeneID" id="81627442"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5477448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="764" mass="86292" checksum="8FD110CF232175E9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2C9</accession>
    <name>A0A9W9X2C9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_006864</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788400.1">
        <property type="nucleotide sequence ID" value="XM_056936465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2C9"/>
    <dbReference type="GeneID" id="81626714"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000068">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="165"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5480970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="389" mass="43429" checksum="2AF46732694B1237" modified="2023-11-08" version="1">MALDNYYRNKIESMKLEIIQGQAVLRRLEAQRNDYNSRVRLLREELGLLQQPGSYVGEVVKVMSTKKVLVKVHPEGKYVVDIADGVDIAKLTVGKRVALLSDSYKLEKMLPSSVDPLVSLMMVEKVPDSTYDMIGGLDQQIKEIKEVIELGLKHPELFESLGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCRFIRVSGSELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRIDSAGGGDSEVQRTMLELLNQLDGFEPTKNIKIIMATNRLDILDPALLRPGRIDRKIEFPPPSVEARADILRIHSRSMNLTRGINLTKIAEKMNGCSGAELKGVCTEAGMYALRERRVHVTQEDFDLATAKILNKHDDKEVAVSKLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2E7</accession>
    <name>A0A9W9X2E7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphotransferase enzyme family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788618.1">
        <property type="nucleotide sequence ID" value="XM_056936683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2E7"/>
    <dbReference type="GeneID" id="81626932"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5481188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="14065" checksum="A67C189B00AE529E" modified="2023-11-08" version="1">MQRSWESGDFWVVYAILHSFAFDAIYWQKIDRRFFGPTETNDPSDAWKERLNLLGEDQKAEMERLVMRKLEEMEDRVLAWDPDEYTEAFRQGLMKRREEQVKEGKESHRGPVEGPHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2F4</accession>
    <name>A0A9W9X2F4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Opsin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_007032</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788568.1">
        <property type="nucleotide sequence ID" value="XM_056936633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2F4"/>
    <dbReference type="GeneID" id="81626882"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15028">
        <property type="entry name" value="7tm_Opsin-1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF2">
        <property type="entry name" value="BACTERIORHODOPSIN _OPSIN, NOPA (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5481138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33138" checksum="8021F523538BB01F" modified="2023-11-08" version="1">MFVPDNMDAFLQATAASLPLTTPTSVAPIPTVIPNVPIYQHHHETGKRTLWVVAVLMGISSLVFFTLAARAPLAKRVFHTTASLVTTLSFITYLALAFGQGIVYKHATVVHHHKHVPNTSEDLYRQVLWLRYLNWAISTPLILINLALVSGLPGANLIPAIVANFAMLGSGLLGTFAGNTPQRWVWLTVSCLSYLTMLHHGAFYAQRAAANKDVKVRRFFGALSGTAFVALALFPIGLAAGSLATKISVDAETIIYAVQDIFSQGILGYWLVLVQDSAQTSSLAVEGFWTSGFASEGSIRITDEDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2I2</accession>
    <name>A0A9W9X2I2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_006103</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the THOC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788629.1">
        <property type="nucleotide sequence ID" value="XM_056935705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2I2"/>
    <dbReference type="GeneID" id="81625954"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000870">
        <property type="entry name" value="WD repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5482657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="39549" checksum="983318E4D4BCB5C9" modified="2023-11-08" version="1">MAPAPRRDLLAKEHFALVFGGVKTQSYYDPAAKGPGSHTIRTLAWNPTGQLIATGSADRTLRIWNPERPAIKYSTELRGHTAGIEKVLFNPVRDAELASCSTDGTVRFWDVRSKTCVSRLDVGGEAFTMSWSADGSTMVVGKKDDTLIPISVQSPSTPTVLSNSSAFNGMAPTGSSKSNASIYQALTPHPQPIQTNATTFSNHVATPSSPDLHLFATTGEGTVKIMSYPSFDTLHTLHAHTSACMAISLAPTGRYLAVGGSDALISLWDTTDWICRRTLSSENGGSIRGVSWSFDGRFICGACDEPYCGGNGLEIFHAETGESIYTIPTAGVHVGVPAVAWHPSRYWLAYSTTHDGPGSGSGGLKIVGAGGGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2X9</accession>
    <name>A0A9W9X2X9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_006212</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788738.1">
        <property type="nucleotide sequence ID" value="XM_056935814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2X9"/>
    <dbReference type="GeneID" id="81626063"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="54"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="243"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="333"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="575"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="580"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5482766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="609" mass="68186" checksum="0430CF62B10FAC68" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X331</accession>
    <name>A0A9W9X331_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788331.1">
        <property type="nucleotide sequence ID" value="XM_056936396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X331"/>
    <dbReference type="GeneID" id="81626645"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5480901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="466" mass="52418" checksum="B3CCD16FF8D44EB5" modified="2023-11-08" version="1">MGFFATSEKRAGGGGSSSSTDSAASDRSRSTAPTLLSDRVVSGGRHPKWSDYEYLDGTPISVSVEEDDEEVEEDYDEGFEDEDDGHHRSQQSVSTYASSTPSHDHDISEEPLFEVEDRDERFPSDALASTPSSFGSLFPSTRRLLIRHDDATIDGNMNLRVDTVVPCRDGYQQDVILFHLRMYDLFSRKFSFRRYCRDSGREVCHSTRKETQSAHDRRPVFRRSLSSMFASLRPGSSHSSHHNGCTQTNDRPKRRDSGYGSDMKHDPKSHAADSAKADPSSCLSSSSPSSSSPHTQDRNLTDTILLEFSNYAHVEVKRRGGTGANRYEYEYWSTRYQWRCGSRREGDLREFSYHLIDTKTSKTIAHLVPDILTPIEAMEEESKGGWVPPSSLWISDPTVYGRMPDIADVIVATGLITLVDDCIRRRWHRERRASTLSSTGAALSRSLERMGPRRLIGEVLHRRGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X367</accession>
    <name>A0A9W9X367_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA-directed RNA polymerases I and III 40 kDa polypeptide</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_006241</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788767.1">
        <property type="nucleotide sequence ID" value="XM_056935843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X367"/>
    <dbReference type="GeneID" id="81626092"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000003">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000005">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="8">
        <location>
            <begin position="63"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00081520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5482795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="375" mass="41999" checksum="3BF47DC5372581E9" modified="2023-11-08" version="1">MAPLIPSQEELQRRRIIGINAETVTNIPSTDFPGHWPGESHSWALDQFKDNFKVEFHRNDPYEASFSLIGLDAAVANAFRRILVAEIPTLAIEYVFVQNNTSVIQDEVLASRLGLIPLKGSVEGINWMHWYRKPSEDDDGPAPPGPSDFNTVVMQLAVECTKNPDAAQDETDPRKLYHNAHVYAKDMTFTPVGRQEQFFTGEGAIQPVNPDILIAKLRPGQKIDLEMHCIKGIGADHAKFSPVATATYRLMPQITIERPILGEDAKKFAKCFPKGVIGLEPVTAEDAKRQGSGYEGHAGEMKAVVRDAFNDTVSRECLRHEEFQGKVKLGRIRDHFIYNVESTGQFESDVLFLEAVKVLKLKCARWKRGLEDLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X4Z0</accession>
    <name>A0A9W9X4Z0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000007">
        <property type="protein sequence ID" value="KAJ5483823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789093.1">
        <property type="nucleotide sequence ID" value="XM_056935625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X4Z0"/>
    <dbReference type="GeneID" id="81625874"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5483823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="227" mass="24801" checksum="E136E6E556FC1404" modified="2023-11-08" version="1">MTRASSSKRALLRTKCREALSTHICKLRSHDGSQITANLFVDERLGLTIAPGQVRLQPLPSDGYSWSATGTSAALLKKSLSSGNLWFYQSICEELGRSLEAVPVQVLKGTAKDKANEACPDSSRVIAGPCSSSFTETILQLEIAISKLKDELSCAHEHLNQSQAENCRLDQALSHTRNELQNSTFENSNLRNKLLSSEVRIAKAIQVLEVTAGKTATESPEDLQMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X506</accession>
    <name>A0A9W9X506_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000007">
        <property type="protein sequence ID" value="KAJ5483838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789108.1">
        <property type="nucleotide sequence ID" value="XM_056935640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X506"/>
    <dbReference type="GeneID" id="81625889"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5483838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="388" mass="44866" checksum="B1C9E4C927F0E2D1" modified="2023-11-08" version="1">MENVPCDGEPNRPREIDPRKTPTCRCKTRSKNLERVNAILRKKLHETEASLKISQDAQLTWAEKTQQQEEQLKKARLLEAENSRRFEKDLEKVRLVEAEKTRRLKEQLEQASDAAAKANKQLVQCLKKVNELQRRTESVDENQIIDRMRSLFRKSETWTTRHFPPKSERSAMDGNTDNSNERNLGLDQNWLPDPQYIQAVLSSAIWFHIFSKPMIGAPDELGGHLSRLEIEVERSCETAPNPENMPSAKMLYSVPSHIWQHWRSATSQSLANINPASGDKACSAILQYMEETCSDHSVSSQNFRVSQLEDLLTACIDFKKQLERQETIYRFEHSYPDTPFCEWYMRSHNGTSPVNSFVCRSLWPGLYKVTSEKTPIMIEKQLVELAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X580</accession>
    <name>A0A9W9X580_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789321.1">
        <property type="nucleotide sequence ID" value="XM_056935449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X580"/>
    <dbReference type="GeneID" id="81625698"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="195"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5484051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="436" mass="51963" checksum="AD7397BFE4EF8B94" modified="2023-11-08" version="1">MSRYDDYRSSTGSFETRDRHERRHSRGPPVMDRPRQVDDERFEFRMREADRYGPPARAPGRYYEDEHLVRSSGALVPHDRRRRRDESPSFAPPRLVRRQSSLDTFDRIPRRKMETLEARDRPRGAPRAPHVPAPPRAAPGHYREREIYEDIRIAEPDLYGDEEFRGFRERRSMDHHRRRSSSGTRSRREEKPYPRKGKTRIPRKWVHVHAILDLGYPFKEDGEVIVIQKALSKEQIDEVISLSKEFRRPAEHVETEYLRVPRSPVRTIPRERVTTEHLVVDSRHRDAHYIEASPHRRERHEEIDYEEYAPRSRTMIVSRPRSVSVNTHARPSTSLQLIEPRNYAEERIETRPRNSGQMVLVRPRESDRELDEYVRELEEEARMLRLERRGGYEVTRDRETDVIDSRGNETEIHEVRRTERREPSAGVMRAMLATLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5G7</accession>
    <name>A0A9W9X5G7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_005980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789454.1">
        <property type="nucleotide sequence ID" value="XM_056935582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5G7"/>
    <dbReference type="GeneID" id="81625831"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000003">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017865">
        <property type="entry name" value="F-actin_cap_asu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00748">
        <property type="entry name" value="F_ACTIN_CAPPING_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00749">
        <property type="entry name" value="F_ACTIN_CAPPING_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0117">Actin capping</keyword>
    <keyword evidence="5 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5484184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="274" mass="30203" checksum="A1437F547F485153" modified="2023-11-08" version="1">MASTIELVSSFIEGAPPGEPPYLTIDVQALTSDGDDILPSLAPAFARYNEGQLATVKLPGSSQEVIVSEFNRLEDNRYFDTESQTSFEMDHTTQTASNAQSSPLESQNADLIKSLLKSLAVHAKEHYPNCSYGVYPIENDSAVAILLVANRYSPNNFWNGRFRAIYQVPVSDSSSSVTGKIHVDVHYYEDGNVAMNTTKPVNLSINSVTAESIISRIATAERDYQEELNRAFVQMAEGAFKGLRRQLPITRQKVEWEKVGGYRLGQDISGGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5U0</accession>
    <name>A0A9W9X5U0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Very long-chain fatty acid transport protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">N7539_004853</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789649.1">
        <property type="nucleotide sequence ID" value="XM_056934455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5U0"/>
    <dbReference type="GeneID" id="81624704"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF6">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY PROTEIN (CEFD1), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="20">
        <location>
            <begin position="81"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="21">
        <location>
            <begin position="520"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ5484865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="654" mass="73171" checksum="B9779400E71A9D1B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5Y2</accession>
    <name>A0A9W9X5Y2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dolichyldiphosphatase</fullName>
            <ecNumber evidence="11">3.6.1.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_004900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a di-trans,poly-cis-dolichyl diphosphate + H2O = a di-trans,poly-cis-dolichyl phosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14385"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="EC" id="3.6.1.43"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the dolichyldiphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.43" evidence="11"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789696.1">
        <property type="nucleotide sequence ID" value="XM_056934502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5Y2"/>
    <dbReference type="GeneID" id="81624751"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047874">
        <property type="term" value="F:dolichyldiphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03382">
        <property type="entry name" value="PAP2_dolichyldiphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000003">
        <property type="entry name" value="Dolichyldiphosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039667">
        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF1">
        <property type="entry name" value="DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="12">
        <location>
            <begin position="52"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5484912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="230" mass="25612" checksum="879A3824D26B350B" modified="2023-11-08" version="1">MGDTPLASLSFTHVHYNPQDPLSFASAWLALAPQALCVSYATLIWASREVEVILMFGGQLGCEALNFALKRVIKEERPKEMFGKGYGMPSSHAQFMTYFAVYMSLFLAFRHSPSYAGSYPYSDFLLRSALIVGLCASAVAVSASRVYLSYHTPQQVLAGSAAGFLCACGWFAVTGLLRRSGWIDWATEMTVCRLLRVRDLLVNEDLAEAGWQQWEALRLKKRSKSLRKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X611</accession>
    <name>A0A9W9X611_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789573.1">
        <property type="nucleotide sequence ID" value="XM_056934379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X611"/>
    <dbReference type="GeneID" id="81624628"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5484789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="219" mass="24615" checksum="92F116EA755B7F39" modified="2023-11-08" version="1">MASRMDPVPKKAKKAIFPPELCLVTVVANFSGDMPRQSTVIEIDDLERRDDISRDGTSAGYGFVKQLDGPYNYLGTTVDDLKLMREQSSRIFQTKAAGDVRTSNNLSHVKSLGERAITNEPTTVTFEPVQEKAEAYSTDLNVKGSIATRYRPDIEDHQIKRTGSDDSDGHAKDLVDECWISRRQRQMHRRRRNRDDSPPNLNAAKSTTKNGFAREDQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6E2</accession>
    <name>A0A9W9X6E2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">N7539_005198</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Associates with polysomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789994.1">
        <property type="nucleotide sequence ID" value="XM_056934800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6E2"/>
    <dbReference type="GeneID" id="81625049"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="167"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="370"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="523"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ5485210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="561" mass="60396" checksum="DCF88AABA68169B4" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6H8</accession>
    <name>A0A9W9X6H8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">penicillopepsin</fullName>
            <ecNumber evidence="6">3.4.23.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">N7539_004974</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates. The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site. Shows a broad primary substrate specificity. Favors hydrophobic residues at the P1 and P1' positions, but can also activate trypsinogen and hydrolyze the B chain of insulin between positions 'Gly-20' and 'Glu-21'.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving 20-Gly-|-Glu-21 in the B chain of insulin. Clots milk, and activates trypsinogen.</text>
            <dbReference type="EC" id="3.4.23.20"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.20" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789770.1">
        <property type="nucleotide sequence ID" value="XM_056934576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6H8"/>
    <dbReference type="GeneID" id="81624825"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000085">
        <property type="entry name" value="Aspartic-type endopeptidase (CtsD), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000060">
        <property type="entry name" value="Aspartic-type endopeptidase ctsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF75">
        <property type="entry name" value="ENDOPEPTIDASE (CTSD), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040987268" description="penicillopepsin" evidence="20">
        <location>
            <begin position="19"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="21">
        <location>
            <begin position="102"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="133"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ5484986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="483" mass="50852" checksum="CFF5A7F9E9A0DF04" modified="2023-11-08" version="1">MRFSPILLVSSIATSVHAFYPYEIKISATVGAPSEEKVIPRFFPWRLVEQASADDASPPQPFTLGIKKGPARRGDTYAIVKSNTPTMKNSAALDQDGEDFSYFAVVDVGSQKQQMWMALDTGSPSSWVFSALCRDSVCQRHHKFDKSQSSSYSSSDSVFTIGYGSGTVSGNLGTDTFGLADMDVTLSFGTATSANDTFASYPFDGILGLGRSRTGGWGIPSFMDVVADKKLLPANIVGFSLSRAKDHKNDGEVNFGAVDTTKFDGNISYIPTSTKTWTIPMDDAYVDGKPLGLTNRAATIDTGTTYILIPPADAAALFAHVPNSYRSGENFIIPCNSTATIEFAFAGIKYSILPEDYIGASSTGGCVATIVGHESSGPNDWLVGDVFLKNVYSVFDFDNGHIGFGALASPNSTGNGTAVIPTATASAGAAMTTVAGAPSRPPSNTSAAATSTIDTVMHTGAATRITHSVGFSFIATLTGILFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6I5</accession>
    <name>A0A9W9X6I5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-tRNA hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790054.1">
        <property type="nucleotide sequence ID" value="XM_056934860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6I5"/>
    <dbReference type="GeneID" id="81625109"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040995963" description="Peptidyl-tRNA hydrolase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5485270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27956" checksum="4A56D38BB4F57D81" modified="2023-11-08" version="1">MRFTSIVALLPALALAQEQVPLADRVQGWFNKAKNLVPSPVPDEPVQKVVEKVSEKHVTPVTMQNWQSILTPAEDPQDWYIFVTGGNKTCFGRCDIAEKAFNESVVLFSADRTSPNLGLLNCEEERVLCATWSAGAPTVFYFQLPQAQPLGQERLPTPLHVVYLNHTTITPQELYQIHSKKTFEDVPAYEGALHPTDGWLAKYQLNVPVGYAIWALGAIPSWSFMILVSFFSRTIMGRRMNNAGNAPRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6K6</accession>
    <name>A0A9W9X6K6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">U3 small nucleolar ribonucleoprotein IMP3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_005421</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790217.1">
        <property type="nucleotide sequence ID" value="XM_056935023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6K6"/>
    <dbReference type="GeneID" id="81625272"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5485433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="188" mass="21769" checksum="CDA5BE2C3609CB86" modified="2023-11-08" version="1">MVRKLKHHEQKLLKKTDLYTYKSDQGHRAGEIQRRYGVTDVEYNTYNALCGSLRKMAHKLSQLEPEDPTRRKLETAMLEKLYSIGVIEKNREQGGALSQVEHLTVSAFCRRRLPIVMIREQKMIQYVDKAIEAVAQGHVRVGTQVVQDPATLVTRNMVDFVQWVPNSKFRVAGQNYHGKRDDFDTLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6N0</accession>
    <name>A0A9W9X6N0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_005322</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790118.1">
        <property type="nucleotide sequence ID" value="XM_056934924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6N0"/>
    <dbReference type="GeneID" id="81625173"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF47">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 122 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="4">
        <location>
            <begin position="182"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="781"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="823"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="787"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="837"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5485334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1025" mass="111304" checksum="104CCF96EF633414" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6T4</accession>
    <name>A0A9W9X6T4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent RNA helicase dbp2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789993.1">
        <property type="nucleotide sequence ID" value="XM_056934799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6T4"/>
    <dbReference type="GeneID" id="81625048"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050334">
        <property type="term" value="F:thiaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19367">
        <property type="entry name" value="TenA_C_ScTHI20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.910.10:FF:000003">
        <property type="entry name" value="Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000034">
        <property type="entry name" value="Putative hydroxymethylpyrimidine/ phosphomethylpyrimidine kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027574">
        <property type="entry name" value="Thiaminase_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04306">
        <property type="entry name" value="salvage_TenA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858:SF17">
        <property type="entry name" value="HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PHOSPHOMETHYLPYRIMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="1">
        <location>
            <begin position="301"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5485209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="517" mass="56512" checksum="31AC9619F1D09539" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X716</accession>
    <name>A0A9W9X716_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_004843</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789639.1">
        <property type="nucleotide sequence ID" value="XM_056934445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X716"/>
    <dbReference type="GeneID" id="81624694"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5484855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="239" mass="26562" checksum="9871BBD1CB001E74" modified="2023-11-08" version="1">MTQIPTIPGSTSLALAILASGYLCALCMTPPNPSPDRTERHQKDRLSFLAGTGATITRRIIVTAIIYHSILTLLPIYASSQTLSTFCPRPQNLNPSLFHWTPTSASALLFVCAGALIRLAAYKSLSRNFTFHLAAPDELVTTGIYGWVQHPSYTGMMLVIGGMVLLVLRWDGAAACFHEEAWQERLRGWGVMVVAGGACVNLGMWFMRMKDEEEMLRGKFGEKWEVWHRSTKRMIPGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7D8</accession>
    <name>A0A9W9X7D8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydrofolate synthetase</fullName>
            <ecNumber evidence="9">6.3.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_005489</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>7,8-dihydropteroate + L-glutamate + ATP = 7,8-dihydrofolate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.12" evidence="9"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790285.1">
        <property type="nucleotide sequence ID" value="XM_056935091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X7D8"/>
    <dbReference type="GeneID" id="81625340"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000010">
        <property type="entry name" value="Dihydrofolate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.20:FF:000010">
        <property type="entry name" value="Dihydrofolate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5485501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="414" mass="44904" checksum="43F75E967C34DE4C" modified="2023-11-08" version="1">MIELGLGRIARLVQQTPLTWSAIHVAGTNGKGSISAYLSYLLSAEGVRCGRFTSPHLIDKWDCITINERVVQESLFRRIESQVRQRDEKLGIGASEFELLTATAFEIFNHERVEVGVVEVGMGGRLDATNVLKHVLVSVIAKIGMDHQAFLGSTIEEIAREKGGILKPGVPCVIDSTNEKGVIETLSNIVQDLGIDASFVSPDKAKEHAPAFAELLKAWDLEPHQEENMCLAASALNIALAQIRPQTDPLRLLPLLAKVRWPGRLENVVLEPLISRSQPVLLDGAHNPQSAAVLGRYVDRKLRANSQPVTWVIAASSGKDLAGVFCSLIHPGDNVATAEFGPVDGMPWVMPTKSTDLASTMSSISDIGQMKSFEGDLLSAMQWASEVSQSGPIVIAGSLYLVSDVHRLLRNAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCP7</accession>
    <name>A0A9W9XCP7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_003727</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790870.1">
        <property type="nucleotide sequence ID" value="XM_056933329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCP7"/>
    <dbReference type="GeneID" id="81623578"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF26">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="552"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="599"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="627"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="30"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="203"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="415"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="805"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="749"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="758"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5488837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="905" mass="100904" checksum="3739A9B0A14DF490" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCS7</accession>
    <name>A0A9W9XCS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790839.1">
        <property type="nucleotide sequence ID" value="XM_056933298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCS7"/>
    <dbReference type="GeneID" id="81623547"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="800"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="839"/>
        </location>
    </feature>
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        <source>
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</entry>
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</entry>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
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            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="652" mass="73681" checksum="38A3686C79E3C7D2" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
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        </source>
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        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDJ8</accession>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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        </citation>
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    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDM0"/>
    <dbReference type="GeneID" id="81624090"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001704">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="458"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5489349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="533" mass="59930" checksum="6AFF3A02C0760D10" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEZ7</accession>
    <name>A0A9W9XEZ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_002616</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="9"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792178.1">
        <property type="nucleotide sequence ID" value="XM_056932219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEZ7"/>
    <dbReference type="GeneID" id="81622468"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050019">
        <property type="term" value="F:L-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF12">
        <property type="entry name" value="L-ARABINITOL 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="41"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="192"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5491049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="386" mass="41278" checksum="8D7BE5450C64519D" modified="2023-11-08" version="1">MSTATTVAKTNIGVYTNPQHDLWIAEAEPKTEDVQSGKTLKPGEVTIEVRSTGICGSDVHFWHAGCIGPMIVTGDHILGHESAGQIVAVAPDVKSLKPGDRVAIEPNVICNECEPCLTGRYNGCERVAFLSTSPVDGLLRRYVNHPAIWCHKIGDMSYEDGALLEPLSVALAAVERSGLRLGDATLITGAGPIGLISLLSARAAGACPIVITDIDEGRLAFAKSLVPEVRTYKVQIGLSAEESAAGIINALNDGQGSGPDALRPRLCLECTGVESSVNSAIWSMKFGGKVFVIGVGKNEMTIPFMRLSTQEIDLQYQYRYCNTWPRAIRLVQNGVIDLHKLVTHRFALEDALKAFETAANPKTGAIKVQIMSSEEDVKAASAGQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFM2</accession>
    <name>A0A9W9XFM2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_002435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791997.1">
        <property type="nucleotide sequence ID" value="XM_056932038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFM2"/>
    <dbReference type="GeneID" id="81622287"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF36">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G01340)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="6"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5490868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="148" mass="16331" checksum="0FD94DD8F02FB9A9" modified="2023-11-08" version="1">MTETYVTGTCLCQEIQYRIALPSSDTLPKVILCHCNNCKRNTGSGFSANIVVLQSQFKYTQGTPKVYTDRSDKGPAVLREFCPSCGTPLSSRTDDGSDDVAVKSGTLSEEDRARCSELGMEIFHHRKDGWIRGMEDVDVPRRNGSMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGW6</accession>
    <name>A0A9W9XGW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_001374</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 6"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793008.1">
        <property type="nucleotide sequence ID" value="XM_056930977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGW6"/>
    <dbReference type="GeneID" id="81621226"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040798508" description="peptidylprolyl isomerase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="36"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5492628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="132" mass="14407" checksum="CE43EA6E67AF3D27" modified="2023-11-08" version="1">MRFATLFLTLASLACAAELGIEVTHKVDCERKTQNGDTVQMHYRGTLQADGKEFDSSYKRNAPLEFALGTGRVIKGWDQGLLDMCVGEKRTLTIPPEFGYGERGIGPIPGGATLVFETELVGIKGVEKNDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH13</accession>
    <name>A0A9W9XH13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_003285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792846.1">
        <property type="nucleotide sequence ID" value="XM_056932887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH13"/>
    <dbReference type="GeneID" id="81623136"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="272"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="666"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="756"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5491718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="821" mass="89868" checksum="EBFEF0E0131E699B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH34</accession>
    <name>A0A9W9XH34_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793256.1">
        <property type="nucleotide sequence ID" value="XM_056931225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH34"/>
    <dbReference type="GeneID" id="81621474"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053144">
        <property type="entry name" value="Acetyltransferase_Butenolide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43233">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43233:SF1">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="191" mass="21981" checksum="6B7E1408F80614BD" modified="2023-11-08" version="1">MSSDPPKAPYAPRTWVRVESDIFVSNDPSLLSIKAVNEAFAQDWLYWGKPFPEEVMYHMLHDSMSFGVYKYTQSLSDGGERVAPSTENTRQIGLARMVTDNVTFGYLSDVYVLPEFQGLGLGRWLMDCISEIFSIENMPNLRRIMLLTGDKRMQDWYAKIFGMEVIAHERRPDIGQDLVFMCVRPNARSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH93</accession>
    <name>A0A9W9XH93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_001331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792965.1">
        <property type="nucleotide sequence ID" value="XM_056930934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH93"/>
    <dbReference type="GeneID" id="81621183"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04813">
        <property type="entry name" value="PA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="3">
        <location>
            <begin position="224"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5492585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="856" mass="91093" checksum="3FB8C955346BA662" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHC6</accession>
    <name>A0A9W9XHC6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Integral membrane protein S linking to the trans Golgi network-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_001738</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793372.1">
        <property type="nucleotide sequence ID" value="XM_056931341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHC6"/>
    <dbReference type="GeneID" id="81621590"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5492992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23268" checksum="815ECA8DAFDF9072" modified="2023-11-08" version="1">MPARRRPPAGSRSDLPPLKIIRKILLLQAAYYVCAFVLILFTTIIYGTPFSLNLVLGWDYLRGDTTIGWMLGLVWILNGVINVIFLLLLVSRSKLVPDFALTIHFLHLVATVVYTRSIPTNLLWWGLQFASAGIMTLLGMWACQHRELQPISFGGFAGLGGDNSASTLQPSSSDAHLEAGFGRGRGRERSLQSGFDEYEMTGLKPDERTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHM5</accession>
    <name>A0A9W9XHM5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_001922</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793556.1">
        <property type="nucleotide sequence ID" value="XM_056931525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHM5"/>
    <dbReference type="GeneID" id="81621774"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14135">
        <property type="entry name" value="STKc_PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000440">
        <property type="entry name" value="CMGC/DYRK/PRP4 protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044092">
        <property type="entry name" value="STKc_PRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="487"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="267"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="81"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="299"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5493176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="807" mass="91037" checksum="A58997265769934C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHQ9</accession>
    <name>A0A9W9XHQ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_001855</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>pyruvate + H(+) = acetaldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:45484"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793489.1">
        <property type="nucleotide sequence ID" value="XM_056931458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHQ9"/>
    <dbReference type="GeneID" id="81621707"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000025">
        <property type="entry name" value="Pyruvate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="17">
        <location>
            <begin position="15"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="15">
        <location>
            <begin position="212"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="16">
        <location>
            <begin position="414"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5493109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="570" mass="62949" checksum="0A402CDC94C9AE78" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHZ9</accession>
    <name>A0A9W9XHZ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_001721</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793355.1">
        <property type="nucleotide sequence ID" value="XM_056931324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHZ9"/>
    <dbReference type="GeneID" id="81621573"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF160">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="17"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5492975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="483" mass="52869" checksum="45837AE9AE0EE2E0" modified="2023-11-08" version="1">MAAVDPRLLPQRVRYAALLTVNVYVFMGNMYGSGITTGFESLGMYFHASNDQLSALVSYSVLAMGLANLLWMPLALCFGKRPVVLFTMVMFLCGLIWSSVAQTYNSLLAARVFASFGYGGIESLGPSILADLFFERNYASAMAAYAAFLSGGSQIGPVIAGYLIGARGWRWFFILCAILAAVNLVTTFFMLPETIYERDEVDDHEVHEDAEKNIKSHLESVQSRSQAGDRAKMNYGDYFKGLFTMGITEEAKKNGVVKHFFYLLVLPLPLLLVPGVLIASIMYGVILGGIVTMSTIIPAVLSPPPYLFSSAQLGLFMLSSFIGVVIAWPIAGPLTDLLSRWMRKRNNNMHKPEHRIPALIIPFLICPIGLVIFGLAFARHESFVTAAVGQAISAAGLTLVPSVMLSYVVDAYPRVSGEALVLVNASKNVVAFGLSKGAYAWLAKEGIDKMFYEFAGIQWACIFLGLPLYFFGPTLRARVDRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI60</accession>
    <name>A0A9W9XI60_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pcc1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793445.1">
        <property type="nucleotide sequence ID" value="XM_056931414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XI60"/>
    <dbReference type="GeneID" id="81621663"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000011">
        <property type="entry name" value="Transcription factor Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5493065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13015" checksum="A124827569951A98" modified="2023-11-08" version="1">MSETEFPYSLTISLPLPSHRLASSALQTLEVDTELSPFVRRTFALTAPASETHGEPQEKKQKQDPEETRTVLQTTYRATTNRMLRVAVNGFMESLGVVLGVMAELDVDVLEAEGFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIH6</accession>
    <name>A0A9W9XIH6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Plasma membrane proteolipid 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_001976</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793610.1">
        <property type="nucleotide sequence ID" value="XM_056931579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIH6"/>
    <dbReference type="GeneID" id="81621828"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF116">
        <property type="entry name" value="PLASMA MEMBRANE PROTEOLIPID 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5493230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="126" mass="13900" checksum="2F39861C86B2F7C9" modified="2023-11-08" version="1">MPFTASDICKIIFAIILPPLGVFLERGCGADLLINILLTILGWLPGIIHALYVSTPLPLGGAMRRDLMLTLNPVTLFSNIEAVDDLPVHLPRCLAGRSPPKKLHDSTQPYYRLPHTLRLSDLLLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XJ55</accession>
    <name>A0A9W9XJ55_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mannan polymerase complex subunit MNN9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_002070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793704.1">
        <property type="nucleotide sequence ID" value="XM_056931673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XJ55"/>
    <dbReference type="GeneID" id="81621922"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF6">
        <property type="entry name" value="MANNAN POLYMERASE COMPLEXES SUBUNIT MNN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5493324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="380" mass="42583" checksum="86A7AD498FDEDAB4" modified="2023-11-08" version="1">MAVARSMRRTSPISIVLAAVLAFGFIIFVLSPSSSSVSASASATSSQQRQDDAAEHPLSPPTKPFLKDQRLRSDGLRAAPPVVHYNLNNLTSSNNALANRERILILTPLARFYPEYWENLVQLNYPHELISLGFIAPKTKDGNAAVSALEQAIQVTQTGPVDNRFASISILRQDFEPPLHSQDEKVRHQLSSQKERRESMSRARNSLLFTTIGPSTSWVLWLDGDIVETPASLIQDLTSHNQPVIVPNCYQRYYDTKAKKWDVRPYDYNSWIDSDQAQNLGAQMGPDEILLEGYAELPTYRTLMAYLANLNSLDPRRMIELDGVGGTALMVKADVHRDGAMFPAFPFYHLVETEGFAKMAKRLGYTVAGLPDYFVYHYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XKZ5</accession>
    <name>A0A9W9XKZ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4-formylbenzenesulfonate dehydrogenase TsaC1/TsaC2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_000038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793935.1">
        <property type="nucleotide sequence ID" value="XM_056929642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XKZ5"/>
    <dbReference type="GeneID" id="81619891"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5494922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="253" mass="27212" checksum="474A542AF24788C9" modified="2023-11-08" version="1">MTTQGNRLQGKVAIVTGAASGFGAAIARRYLEEGARVLGADINWPSQEAPSENPNYVTLNMNVASKQDWETAIHTASDKFGRLDIVVNNAGTSYRNKPTAEVTEAEWERVFDVNVKSIYYAAQLVMPVLIQQGQGGSMINISSTGATRPRPGLVWYNSSKAAVTNATKGLAAEYGPHNIRVNSVAPLLSGTGLFSMFTGMEDTPENRQKFIGNVPLGRLTEADDIANMCVYLGSDEGRFINGTEMVIDGGKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XL28</accession>
    <name>A0A9W9XL28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_000103</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794000.1">
        <property type="nucleotide sequence ID" value="XM_056929707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XL28"/>
    <dbReference type="GeneID" id="81619956"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01856">
        <property type="entry name" value="YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000009">
        <property type="entry name" value="Mitochondrial GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001753">
        <property type="entry name" value="Mitochondrial GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016478">
        <property type="entry name" value="GTPase_MTG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006230">
        <property type="entry name" value="MG442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="5">
        <location>
            <begin position="134"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="306"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="142"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006230-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5494987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="344" mass="38693" checksum="C79C6226A8483387" modified="2023-11-08" version="1">MAQFVPRQVFPHYGAIPRSYFLGHHRAGLSKMKNMLSSIDYVVECRDYRAPVTSINPMFEEALENKRRLIVYTKRDLGSVPNSPTQKLVERKVRDLDRKSAVFFVSTSSRVDVTPILRHLRDDAEGPDKLVGCRVLVVGMPNIGKSTLINHLRNFGVGKAKALKTGGQPGITRKIASPVKIIERASGSHVYVLDTPGVFMPYVPDADNMLKLALCGCVKDAVISPVTLVDYLLYQINLHDTQAYRRWSEPTNEVMPLLERFAQKTGLLGKGGVPNIDGAALHFIQKWRAGDLGRFILDDLDAEQRRREDPNQQSRLSMSQALKVERINRKQWKANPPDSSSNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM14</accession>
    <name>A0A9W9XM14_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_000628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794525.1">
        <property type="nucleotide sequence ID" value="XM_056930232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XM14"/>
    <dbReference type="GeneID" id="81620481"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5495512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="141" mass="15575" checksum="44F6A6F6796F58DE" modified="2023-11-08" version="1">MKLAKLLTEYLLIIWDRMDPSDKVSLGCSFLGTMSIFTRSGVLKLLENLGKDKAASTIANDHSSKSVPHPAWGSLCYAICPSEGVFPSMTVWQNLAVHYHLDFAICIFQPLGLHLRAQSMIVGHVSFLNPLVKRHPGAARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMS7</accession>
    <name>A0A9W9XMS7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_000551</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794448.1">
        <property type="nucleotide sequence ID" value="XM_056930155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMS7"/>
    <dbReference type="GeneID" id="81620404"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000002">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="18"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5495435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="352" mass="37455" checksum="CA35CAD97B1924B6" modified="2023-11-08" version="1">MAPQVPEKQWAQVVEKKGGPPIYKEIPVPKPGPDEVLVQIKYSGVCHTDLHAMNGDWPLPLKMPLVGGHEGAGIIVAKGELASGVEIGDYAGIKWLNGSCLSCEYCKTADEPLCAGQQLSGYTVDGTFQQYAIGKAAHVTLLPKDIPLDGVAPVLCAGVTVYKGLKESEARPGQTVAIVGAGGGLGAMAQQYAKAMGLRVIAIDGGDEKREMCEKLGSEVYIDFTKSKDLVADVKAATPNGLGAHAVILLAVSEKPFQQAVEYARPRGNIVAIGLPANAFLKAPVFETVVKMINIKGSYVGNRQDAAEAVDFYARGLIKIPFKTVPLKDLPKVFELMEQGKIAGRYVLQMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMX6</accession>
    <name>A0A9W9XMX6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="16">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">N7539_001067</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="16"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794964.1">
        <property type="nucleotide sequence ID" value="XM_056930671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMX6"/>
    <dbReference type="GeneID" id="81620920"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="20">
        <location>
            <begin position="525"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="127"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ5495951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="886" mass="101009" checksum="8DCF8405270593F5" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN11</accession>
    <name>A0A9W9XN11_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stc1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795002.1">
        <property type="nucleotide sequence ID" value="XM_056930709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN11"/>
    <dbReference type="GeneID" id="81620958"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024630">
        <property type="entry name" value="Stc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12898">
        <property type="entry name" value="Stc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stc1" evidence="2">
        <location>
            <begin position="12"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="201" mass="22319" checksum="333F78A706C8FBD6" modified="2023-11-08" version="1">MQTIKLPDTITCALCERQLPLERFTPSALKRLRTMIVQKGVGALKDQQIARCDGCGTQSRPELHCMSCNQVRPINEFAHTQRQFDQPVCLPCQDNLQLDERDKLASNQSGGGLIEADVEQDIDERSDPMAVFPMDIDIAQQDIPQEAGLGETAAGPTLQESDENALTSQPRMATLTSESSRVAPRPPQKIIQDMELELLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN67</accession>
    <name>A0A9W9XN67_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_000791</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794688.1">
        <property type="nucleotide sequence ID" value="XM_056930395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN67"/>
    <dbReference type="GeneID" id="81620644"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF10">
        <property type="entry name" value="L-ORNITHINE N(5)-OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5495675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="537" mass="60829" checksum="F7BE96F89E9967C6" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XNA8</accession>
    <name>A0A9W9XNA8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-repressible protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795159.1">
        <property type="nucleotide sequence ID" value="XM_056930866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XNA8"/>
    <dbReference type="GeneID" id="81621115"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020100">
        <property type="entry name" value="Glc-repressible_Grg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789:SF1">
        <property type="entry name" value="GLUCOSE-REPRESSIBLE GENE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789">
        <property type="entry name" value="REPRESSIBLE PROTEIN GRG1, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11034">
        <property type="entry name" value="Grg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5496146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="71" mass="7405" checksum="5158B758B7F9F7CA" modified="2023-11-08" version="1">MESVKQAANYVSESIQGTGAQASKEANKNVAKDSDASLGTRASAAKDAVVDKKDESVHDTKADTNKEAAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ40</accession>
    <name>A0A9X0BJ40_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_009377</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785694.1">
        <property type="nucleotide sequence ID" value="XM_056938972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJ40"/>
    <dbReference type="GeneID" id="81629222"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="11">
        <location>
            <begin position="63"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5466648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="366" mass="39938" checksum="D8A7B138A2E033B5" modified="2023-11-08" version="1">MRHSEEREEAELALLSGNEDSTSNTDIDDLDFEDLEANRKEESSTTIAEPVEYQTPTTVKFIWVTCYFGFSMALTIYNKLVLGSFRAPWLLTCLHTSFSALGTLILLQMGYFKLSTLGRREHLILVLFSILFTTNIAMSNLSLSLVSLAFFQIIRNMVPLFTVLIYRVWFSRTYATGTYLSLIPIVVGAGMCTAGDYHFTLLGLLVSISGVILAAVKTVTTNRIMTGSLAMPSMELLFRMAPLAAVQSLFFAAVSGEIPVFLHAMSERNADGALSRTLITVVFIVGNGLLAFVLNIASFQTNKIAGALTITVAGNLKQAITLALGILVFADFTINVLNGLGIFLVLAGCACFSKVELDSKRRAATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BLS0</accession>
    <name>A0A9X0BLS0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_008625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786602.1">
        <property type="nucleotide sequence ID" value="XM_056938220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BLS0"/>
    <dbReference type="GeneID" id="81628470"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00876">
        <property type="entry name" value="IDO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5472056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="385" mass="42631" checksum="C20FCA631627196C" modified="2023-11-08" version="1">MYYAKWEAIVADLQPLLLSKRIRLMIDRLPRLSTDHLQAVAEWRRAYVILVFLLHSYIWGGDQPTERISPQLTVPLFQVCERLEVPPVATYAGVCLWNYKPICADEPTNGLNSLACLQTFTGSLDEQLFYLVSVAIEAQGAPALPLMLQAITAARAGDTYQYRQYGGGSNAQSSLIQFFDIVLGVEHRPTGVTCNEQKKSRSISDTAELGPGSIHEMREYVPGSHRRFLQDVEAVANIRSYVRTRPTDLALQSAYDACLLVLRNMRDRHIQVVSRYIVVQSRMNQQTPEPDMYPTAMNLATLGPKNSKGLFGTGGTALIPFLKQPRDETGEPVINAWARRLPSQPSSLGPGSLSEVEGQAGGYLQVVDLCGTWTAGDSEGGICRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNC5</accession>
    <name>A0A9X0BNC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786986.1">
        <property type="nucleotide sequence ID" value="XM_056937894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNC5"/>
    <dbReference type="GeneID" id="81628144"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5475228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="112" mass="12650" checksum="5ECC531415D314DD" modified="2023-11-08" version="1">MRIYRESRCEDPLASVDSTRAYSVSVDAKHTKLSEVSLLSRRVEPAEQRNRQVIRLVNGESNLEIITEVPSWRIGRDQGANLIGFRWSRTVQPRLVMTTGAWLGSSGHLDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNE4</accession>
    <name>A0A9X0BNE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786880.1">
        <property type="nucleotide sequence ID" value="XM_056937788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNE4"/>
    <dbReference type="GeneID" id="81628038"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="42735" checksum="E48FD58A454BD1F7" modified="2023-11-08" version="1">MTLTPPFPSPARKPKNPGSMSSQRETPASPYSKSPRAVTTQSPASEDAVDPSSADDETVGSIFDEDEDYHSDTSSFTASLLSGIEEHVYENGRRYHSYRAGHYVLPNDEQEQDRQDLLHHVRNLVLEGALFRAPLQIDAVQRVLDIGTGTGIWAIDFADCYSHTEVIGTDLSPIQPSWVPPNLRFLVDDAESPWLFNVNRPFDFIHARDLGGAIADWPRLLAQAYHHLKPGGWIELQEFEVTLKSDDGSMDLAPTLCDYLHYLHKASLAFQRPMNIAEGHRRRLVDAGFEEVKDEVYKVPSSGWSTDSVQKEIGRYNLCSLLMAVESYSLALFTRVLGWSNNETQVFLAGVRRDLRNPEVHTYCNLHVVYGRKPDICDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNE7</accession>
    <name>A0A9X0BNE7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="10">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_008369</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787061.1">
        <property type="nucleotide sequence ID" value="XM_056937969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNE7"/>
    <dbReference type="GeneID" id="81628219"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000019">
        <property type="entry name" value="Small nuclear ribonucleoprotein G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5475303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="78" mass="8888" checksum="EB8DF71B73FFB8B6" modified="2023-11-08" version="1">MPQAQPELKKYMEKRVFCQLNGNRKVIGILRGYDVFMNIVLDEAFEEKSGGEKVSIGMVVIRGNSVVMLEALERINEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNE8</accession>
    <name>A0A9X0BNE8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_007756</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM234 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787222.1">
        <property type="nucleotide sequence ID" value="XM_056937357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNE8"/>
    <dbReference type="GeneID" id="81627606"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018908">
        <property type="entry name" value="TMEM234"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10639">
        <property type="entry name" value="TMEM234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="48"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5475469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27055" checksum="83677B7674675F08" modified="2023-11-08" version="1">MDPDASLPTDSSPSVFNYVLSFLLVGVAWGFTTPFIRRAAADFNARQEKQKQASLSGPTSRDSLGRGRSSTHTDTRAGNGTEEEQGPDLLPVSEAEGRPPHADVIDFGEGVRRRSGSSQWEEGEEPEQEQRNGDIPTPAWMQSPSRQSWLRAKMVSVFWTVVNLLRTPAYSVPLVVNLTGSIWFFLLVGKHELSLTVPLANSSAFLFTVLGEWYVERKVIAKETWLGLILVLGGIALCVHSKNQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNG8</accession>
    <name>A0A9X0BNG8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="8"/>
            <end position="20"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5475690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="91" mass="10896" checksum="0B828C3C5A2CCC88" modified="2023-11-08" version="1">MLADRESSAYSAIHGSQQRASNGSYLLARSALWYGRPSLHRVLQSEPRGSVNELNDSGGRKSHEVLNKEYTNESPRHYYYYYYYYYYYYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
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            <strain evidence="2">IBT 30728</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="105"/>
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        </source>
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            <dbReference type="EMBL" id="KAJ5477199.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="105" mass="11593" checksum="444F773C3A3C6668" modified="2023-11-08" version="1">MIISAPDQFDIRIVDSSITAAAPRPQSLVSLTDPLYYAYLAGFFYLIACRGDEHDGRVEWNQGVALTEAPLGHCFGEMQDQQRLDSTSRSVEDRCSAQPQSADPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSI0</accession>
    <name>A0A9X0BSI0_9EURO</name>
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            <fullName evidence="6">tRNA-specific adenosine deaminase subunit tad2</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Penicillium diatomitis</name>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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            <strain evidence="6">IBT 30728</strain>
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    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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            <strain evidence="6">IBT 30728</strain>
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    </reference>
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        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480983.1"/>
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    </dbReference>
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        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
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        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
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            <end position="67"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5480983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="223" mass="24920" checksum="EFE0D8F1289D5A86" modified="2023-11-08" version="1">MDEAFSEIEITPAVSENSKHAQWMKAALDMGEKALEHGETPVGCVLVHNDKIVGRGMNDTNRSMNNSLKRRTSTSWKPPHAKISWQGTRHAEFLAIAEFLQSFPKSALQSTDLYVTVEPCIMCASALRQYRIRSVYFGCANDRFGGTGGVLTIHADRSIDSAYPVYGGLFQKEAIMLLRRFYIQENTKAPVPRAKKHRELNTAFDQVREITATNGVEVLPSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BST6</accession>
    <name>A0A9X0BST6_9EURO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Penicillium diatomitis</name>
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        </citation>
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        </source>
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    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480966.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056936461.1"/>
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    <dbReference type="GeneID" id="81626710"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="KAJ5480966.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="88" mass="9794" checksum="7D8323C54D59AC4F" modified="2023-11-08" version="1">MPVQGLMCIIVNHLTRSIPQQKAEGSPFDKLVNWRVCGQAANCPIAPTCRCCILLVTLVYYYYYSTTLNYGLLYPLTAPSVSTPPHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSW8</accession>
    <name>A0A9X0BSW8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">N7539_006965</name>
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    <organism evidence="22 23">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788501.1">
        <property type="nucleotide sequence ID" value="XM_056936566.1"/>
    </dbReference>
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</entry>
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</entry>
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</entry>
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    <name>A0A9X0BTS8_9EURO</name>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="12">IBT 30728</strain>
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    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789192.1">
        <property type="nucleotide sequence ID" value="XM_056935320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BTS8"/>
    <dbReference type="GeneID" id="81625569"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040952360" description="endo-1,3(4)-beta-glucanase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="25"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5483922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="363" mass="38926" checksum="B67A974BFA934CDB" modified="2023-11-08" version="1">MHVLSTLVSSLGLLAQITRAAYTLQDDYGTTDSFFDKFDFFTDADPTNGYVSYVDRSTATNAGLIRSTGSSVYIGVDTQNQASGSGRQSVRLTSTKSYQHGLVILDLAHMPGSVCGTWPAFWMLGANWPNNGEIDIIEGVNTQSNNQVTLHTSDGCSIQNSGFTGSLDTANCYVEAAGQSANSGCAITSNSGQSYGDGFNQAGGGVYATEWTSAGIKVWFFPRSGIPWDISSGKPNPATWGMPTAAFAGSCDIDSHFNNLQLVFDITFCGDWAGNVWSSGTCAYKAPTCNSFVQNNPAAFKETYWSVNSLKVYQDNGSPLLSIHAHAAAHIGAKQSISQLISRRGTAPYIRPGPRPEWREHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BU48</accession>
    <name>A0A9X0BU48_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Alpha-galactosidase</fullName>
            <ecNumber evidence="5 12">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_004771</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="5 12"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789567.1">
        <property type="nucleotide sequence ID" value="XM_056934373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BU48"/>
    <dbReference type="GeneID" id="81624622"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005995">
        <property type="term" value="P:melibiose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000202">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006215">
        <property type="entry name" value="Glyco_hydro_melibiase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF75">
        <property type="entry name" value="ALPHA-GALACTOSIDASE MEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00748">
        <property type="entry name" value="MELIBIASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040809218" description="Alpha-galactosidase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="14">
        <location>
            <begin position="330"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5484783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="471" mass="51188" checksum="994B1B387D6D009F" modified="2023-11-08" version="1">MRVVPLFLAVGLAAALDNGLAVTPQLGWNTWNSFACSMNETVILDAAKRIVDLGFKDLGYNYVVLDDCWSSGRNSSGYLVPDKSKFPNGIADVANKIHDMGLKIGIYSSAGTMTCAHYAGSLGYEKKDAEVWASWGVDYLKYDNCFNLGEEGTPKLSYDRYNAMGKALNETGRPILYSLCNWGVDGPWNFAPTMANSWRMGGDLTNVWDREDVNCPCAEHEGLDCKLPGYHCSVMNTLNKAVFFAQKAYPGAWNDLDMLQVGNGGLTEDEAISHFSLWAALKSPLLMTNVMTKIDGTTLSILQNTAVLAVSQDPKGSSAVRIWRYYVDGGEIQMYSGPLGGNDQVVLLLNSGSKALDMNATLTDIFWLSGAEGTAPQLKYEWDVYDLWAGRMSNDTANAIINHNANATRPINMTAQGGASKVYAQVPLPTSSALMGKKVSTVKAGGTVKAHVKSHGVAMFRLRAVMNKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BU94</accession>
    <name>A0A9X0BU94_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP:AMP phosphotransferase, mitochondrial</fullName>
            <ecNumber evidence="5">2.7.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylate kinase 3</fullName>
            <shortName evidence="5">AK 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ADK2</name>
        <name evidence="9" type="ORF">N7539_005735</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:13749"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adenylate kinase family. AK3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.10" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BU94"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046899">
        <property type="term" value="F:nucleoside triphosphate adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046039">
        <property type="term" value="P:GTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046041">
        <property type="term" value="P:ITP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03169">
        <property type="entry name" value="Adenylate_kinase_AK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028586">
        <property type="entry name" value="AK3/Ak4_mitochondrial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="8">
        <location>
            <begin position="166"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="5">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="5">
        <location>
            <begin position="165"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="21"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="69"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="175"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5483939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="255" mass="27877" checksum="4CD1BAA1475F5B20" modified="2023-11-08" version="1">MSKSTRQLKKAARIILVGAPGVGKGTQSERLLARFPQLASISSGDLLRENVRRRTPLGLEAEAAMQSGNLVPDSMILSLISSELKSKGWLPSSSPSSSTSASNESSASFPDDSTASTSLCPSASFILDGFPRTASQANSLDGLVPVNFVVNLITPPSVILSRIASRWVHEPSGRVYNTDFHAPKVAGKDDVTGEPLTQREDDSIDTWKQRLRKFEETSRALLEHYERRGCLWRVEGNSSDEISPKLFAEIERRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BVA1</accession>
    <name>A0A9X0BVA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790229.1">
        <property type="nucleotide sequence ID" value="XM_056935035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BVA1"/>
    <dbReference type="GeneID" id="81625284"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040923002" description="Secreted protein" evidence="2">
        <location>
            <begin position="34"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5485445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7961" checksum="CD58382D9B158D7A" modified="2023-11-08" version="1">MLLYAPPKRDALRSWAMAKLALFLIMRSSVTEAEGSRTRGCANNEALKVNQENPMRDSRRHVPTLPIWPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXL1</accession>
    <name>A0A9X0BXL1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_003348</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790491.1">
        <property type="nucleotide sequence ID" value="XM_056932950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXL1"/>
    <dbReference type="GeneID" id="81623199"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
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    <name>A0A9X0BY74_9EURO</name>
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</entry>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZM2</accession>
    <name>A0A9X0BZM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_001443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793077.1">
        <property type="nucleotide sequence ID" value="XM_056931046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZM2"/>
    <dbReference type="GeneID" id="81621295"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5492697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="132" mass="14742" checksum="94222DE9F2E82472" modified="2023-11-08" version="1">MSFNVYTAEYAGVPNHEAIYIETNPAAQRTSEGGRLYHVTGNLLQGMKYDPRGSMDPEFSASHVPGTKRKIGTIAREDLARFDTECCQAVPAPRAQLTLGGKQLYPGTQLYRCGDWLRDVQKLAFEKGIFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZP8</accession>
    <name>A0A9X0BZP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxyvinyl-carboxyphosphonate phosphorylmutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate lyase/PEP mutase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793018.1">
        <property type="nucleotide sequence ID" value="XM_056930987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZP8"/>
    <dbReference type="GeneID" id="81621236"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000009">
        <property type="entry name" value="2-methylisocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF15">
        <property type="entry name" value="PHOSPHONOMUTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G03820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00061405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5492638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="304" mass="32042" checksum="79D012C89344173F" modified="2023-11-08" version="1">MSVNTGASNLRKVLEDPNGFVCAPGVYDGLSARMALGAGFDALYMTGAGTAASVHGQADLGICTLNDMRANAEMIANLSPSTPLIADADTGYGGPIMVARTTEQYARAGVAGFHIEDQVQTKRCGHLGGKQLVDLPTYTTRIRAAVQARKRIGSDIVVIARTDALQSLGYDESLTRLRAARDAGADMGFLEGVSSREMAAQAVQDLAPWPLLLNMVEHGATPSLTAQEAMELGFKMIIFPFATIGPALTAMREGLEKLKRLGLPGLDPELTPQMLFRVCGLDESVKLDADAGGAAFEGGVDLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZZ5</accession>
    <name>A0A9X0BZZ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793318.1">
        <property type="nucleotide sequence ID" value="XM_056931287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZZ5"/>
    <dbReference type="GeneID" id="81621536"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000146">
        <property type="entry name" value="Clathrin-coated vesiclec protein (Bud7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000149">
        <property type="entry name" value="Clathrin-coated vesiclec protein (Bud7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="681" mass="76787" checksum="48A1C58E51468B90" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0B9</accession>
    <name>A0A9X0C0B9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_001912</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793546.1">
        <property type="nucleotide sequence ID" value="XM_056931515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0B9"/>
    <dbReference type="GeneID" id="81621764"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17483">
        <property type="entry name" value="MFS_Atg22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044738">
        <property type="entry name" value="Atg22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="139"/>
            <end position="161"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <end position="227"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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            <end position="290"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="296"/>
            <end position="316"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="533"/>
            <end position="550"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5493166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="602" mass="68348" checksum="512BEAA014372B33" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0M7</accession>
    <name>A0A9X0C0M7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-1,3-glucan synthase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_002031</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19749"/>
            <dbReference type="Rhea" id="RHEA-COMP:11150"/>
            <dbReference type="Rhea" id="RHEA-COMP:11151"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28100"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.183" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793665.1">
        <property type="nucleotide sequence ID" value="XM_056931634.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81621883"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047657">
        <property type="term" value="F:alpha-1,3-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070600">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11323">
        <property type="entry name" value="AmyAc_AGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03791">
        <property type="entry name" value="GT5_Glycogen_synthase_DULL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000058">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000073">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000052">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058659">
        <property type="entry name" value="Mok11-13/Ags1-like_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058656">
        <property type="entry name" value="Mok11-13/Ags1-like_GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058657">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058658">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058655">
        <property type="entry name" value="Mok11-14/Ags1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058654">
        <property type="entry name" value="Mok11-14/Ags1-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182:SF7">
        <property type="entry name" value="ALPHA-1,3-GLUCAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26127">
        <property type="entry name" value="12TM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26122">
        <property type="entry name" value="CBM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26108">
        <property type="entry name" value="GH_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26114">
        <property type="entry name" value="Ig_2_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26111">
        <property type="entry name" value="Ig_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040835074" description="alpha-1,3-glucan synthase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="2450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1101"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2025"/>
            <end position="2047"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2059"/>
            <end position="2076"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2083"/>
            <end position="2105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2195"/>
            <end position="2220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2240"/>
            <end position="2257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2277"/>
            <end position="2296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2305"/>
            <end position="2326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2349"/>
            <end position="2369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2376"/>
            <end position="2398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2422"/>
            <end position="2442"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="10">
        <location>
            <begin position="68"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1670"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1699"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1750"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1766"/>
            <end position="1775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5493285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="2450" mass="274073" checksum="22BD9B22CD72E156" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0P7</accession>
    <name>A0A9X0C0P7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_001955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793589.1">
        <property type="nucleotide sequence ID" value="XM_056931558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0P7"/>
    <dbReference type="GeneID" id="81621807"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF79">
        <property type="entry name" value="LACTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="57"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5493209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="537" mass="59133" checksum="6AD7104908D298AF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2S0</accession>
    <name>A0A9X0C2S0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DEAD box helicase involved in nonsense mediated decay</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_000470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794367.1">
        <property type="nucleotide sequence ID" value="XM_056930074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2S0"/>
    <dbReference type="GeneID" id="81620323"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZNFX1" evidence="5">
        <location>
            <begin position="112"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="297"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="4">
        <location>
            <begin position="688"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5495354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="942" mass="106184" checksum="8875D3D864E4C9CF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2S4</accession>
    <name>A0A9X0C2S4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794966.1">
        <property type="nucleotide sequence ID" value="XM_056930673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2S4"/>
    <dbReference type="GeneID" id="81620922"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="68" mass="7618" checksum="3883D09A9B376AF5" modified="2023-11-08" version="1">MSSPLEVCEFRTSPDSRQLWFVDLQSGRARPPRQATKFKERPVGLHPIDADAVGGEERGGHEISEQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKK5</accession>
    <name>A0A9W9WKK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_009492</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785809.1">
        <property type="nucleotide sequence ID" value="XM_056939087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKK5"/>
    <dbReference type="GeneID" id="81629337"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
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        <location>
            <begin position="42"/>
            <end position="243"/>
        </location>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5466763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="245" mass="27361" checksum="7B3E03C995BD1B1D" modified="2023-11-08" version="1">MASKEAVPSPAQGVGPTYRTDEEKPTATVSKKVSYENVHVLPQTPQLIALLTMIRDKRTVRADFIFYSNRIIRLLVEEGLNHLPVVEQSVTTPVGRDYLGVKFEGKICGVSIMRAGEAMEQGLRDCCRSVRIGKILIQRDEETCMPKLFYDKLPADIADRWVLLLDPMFATGGSATLAVEVLMQRGVPEHRILFLNLIASPSGVAEFAERFPKLRVVTAFIDQGLDDKKYIIPGLGDFGDRYYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKN2</accession>
    <name>A0A9W9WKN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">N7539_009439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785756.1">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5466710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="330" mass="35435" checksum="00002DFA071FB63B" modified="2023-11-08" version="1">MLSQSQVQPPAHASPSYQSHSHHQPHNQQQVQQPPPPPPPLQHHQHPGQYHYQQAPPPPPPPTPSAQSTPTSIPRSDGPGGPASIHDPSIRKRPLYPAEKPSAPRAIQPRPPASTASYSSESSAQLSPRFETALASEPPRKRGRPSKAETERRKAAAEARGETYPPPRRAGSTRVKNPQSPPSPPPASLAMYSSGPAAAPSRRGPNHGPHAYEAAVGRPLAPAPMFSAGERGEMPDRHSRGGNMRELPRLDEMSKPLPSPRTLHLGPIDQFGRFTGTTPGERSSFGSIPPDRFSPADSGRRDSATSRGETSMGPYTDVRASMTPSDKPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKU0</accession>
    <name>A0A9W9WKU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Striatin Pro11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_009523</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
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        </lineage>
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    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785613.1">
        <property type="nucleotide sequence ID" value="XM_056939118.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81629368"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="7">
        <location>
            <begin position="25"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="752"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="388"/>
        </location>
    </feature>
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        <location>
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            <end position="616"/>
        </location>
    </feature>
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        <location>
            <begin position="44"/>
            <end position="99"/>
        </location>
    </feature>
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        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
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        <location>
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            <end position="320"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
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        </location>
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        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
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        <location>
            <begin position="587"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5466567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="831" mass="89976" checksum="168FD861984F5D4A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL75</accession>
    <name>A0A9W9WL75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_009128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786100.1">
        <property type="nucleotide sequence ID" value="XM_056938723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL75"/>
    <dbReference type="GeneID" id="81628973"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5469510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="86" mass="9877" checksum="7318ABFC85EE8A59" modified="2023-11-08" version="1">MSIMDSTRQWNLYHKARIALLTITPHSLNLSFDKLKSHAVTLDEIKTQSDDTVETVKGRRDGLVNQIKLLKWVSMIYMSHAFCTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLF9</accession>
    <name>A0A9W9WLF9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription initiation factor TFIID subunit 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_009190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786162.1">
        <property type="nucleotide sequence ID" value="XM_056938785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLF9"/>
    <dbReference type="GeneID" id="81629035"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000037">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="8">
        <location>
            <begin position="509"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="237"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="244"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5469572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="619" mass="67518" checksum="6805972437D67DA7" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WM04</accession>
    <name>A0A9W9WM04_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle subunit SRP14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Signal recognition particle 14 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_009270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SRP14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786242.1">
        <property type="nucleotide sequence ID" value="XM_056938865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WM04"/>
    <dbReference type="GeneID" id="81629115"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003210">
        <property type="entry name" value="Signal_recog_particle_SRP14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12013">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02290">
        <property type="entry name" value="SRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="53"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5469652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="138" mass="14643" checksum="CFA6DE3B05939245" modified="2023-11-08" version="1">MAPHLDNEARVSFQFFSSLAELLAKTSQQAHGSVFLSQKPLIDGVSNSSPSILIRATDGNTNAPNPKSAGEGSGVAKTTSSKNKNKVKLSTIVESQNLDGFYTRYADICKAGMTGLKKRDRSKRKAKGKSGAAKTPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WM35</accession>
    <name>A0A9W9WM35_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786287.1">
        <property type="nucleotide sequence ID" value="XM_056938910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WM35"/>
    <dbReference type="GeneID" id="81629160"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040957242" evidence="1">
        <location>
            <begin position="18"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5469697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="138" mass="14886" checksum="C9DDC4424E64473D" modified="2023-11-08" version="1">MHLGATLVGVFAMAAMASPFVPPKVLKYTSWDLAFLSAALPVCNPNVTDYSIIITHRRVKGNLDCQPLPSDLNSTNVKSISWKSPNENDAHDLCMFSTDDCSGGEAALLDSITDGWAICYPYNGFRSWSVVSHGASCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WR19</accession>
    <name>A0A9W9WR19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786609.1">
        <property type="nucleotide sequence ID" value="XM_056938227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WR19"/>
    <dbReference type="GeneID" id="81628477"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5472063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="719" mass="80656" checksum="A80542682626B0C5" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WRA1</accession>
    <name>A0A9W9WRA1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786685.1">
        <property type="nucleotide sequence ID" value="XM_056938303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WRA1"/>
    <dbReference type="GeneID" id="81628553"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5472139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="90" mass="10070" checksum="34B7FCBDE901092C" modified="2023-11-08" version="1">MESFTSRLEPDDSQKYFVVIADVEEQIVRTLNPIKLAVFEGRDFTPAVYLEIVPLVVQLTFQGPLLLPSVALSVFRLKLCCVANENLISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU08</accession>
    <name>A0A9W9WU08_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_008372</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787064.1">
        <property type="nucleotide sequence ID" value="XM_056937972.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81628222"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002145">
        <property type="entry name" value="ABC transporter (MsbA subfamily)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF404">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="878"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="928"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1018"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1111"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1145"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="279"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="602"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="907"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1207"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="817"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5475306.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1450" mass="161261" checksum="FD06064832250BD2" modified="2023-11-08" version="1"> </sequence>
</entry>
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            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056938024.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81628274"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5475358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="99" mass="10631" checksum="19DCA8C468C78316" modified="2023-11-08" version="1">MTRGYAALHKKITHVVNWCGNPRLIVGQVPSRRRTQAPGWTLGGYLNSMNYGPGGQSLIQVGGQEELKVDRAGLEIAAAAVKGIYLATNILLMEPSAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUS5</accession>
    <name>A0A9W9WUS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
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            <taxon>Penicillium</taxon>
        </lineage>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477101.1"/>
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    </dbReference>
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    <dbReference type="GeneID" id="81627095"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
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            <end position="50"/>
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        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5477101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="67" mass="8273" checksum="63FFADE0D550E0F1" modified="2023-11-08" version="1">MIVTTIYSYSWEGLGRLQSVSKDEKKEKKEKKEKKEKKEKKEKKEKKEKKEKKEGKKEEKKERKKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUZ2</accession>
    <name>A0A9W9WUZ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="81627187"/>
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    </dbReference>
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        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
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    </dbReference>
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        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF267">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="71"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="49"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5477193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="348" mass="38295" checksum="154BE7BC1153266C" modified="2023-11-08" version="1">MLKKKSLAPAFFWNFSPSTTPELSPTSSDSDSDEDMESSGSRPREPFCPMRPTLKEVLANTAAPPYTLSAFMAYLSQNHCLETLEFTMEASRYRETYHTLSSRFGPEVLTRPDSRESQHLLMLWQRLMTAYILPGAPREVNLSSEVRDALLQHGNVTLPPAPETLDSAVQRIHDLMEESIFLPFLNSQAVSPSVEAQADSPISPDDVMDLSNISCDDHSMKYFRSRTKRISPQSSTKDLSTTAGRSSSSFSAMQALGKRASGALLSPSGDSYTPSLTDDSISQSSPTTEEPMTPPTTPPASDLNQPISSPKYRTENPWKKMGLKLGFKKRSGGSNGNSRDPKILSIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVA3</accession>
    <name>A0A9W9WVA3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kri1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_007537</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_056937138.1"/>
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    <dbReference type="GeneID" id="81627387"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="3">
        <location>
            <begin position="471"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="532"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="577"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5477393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="611" mass="70273" checksum="24702CE8FB82EE6F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVL7</accession>
    <name>A0A9W9WVL7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788021.1">
        <property type="nucleotide sequence ID" value="XM_056937222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVL7"/>
    <dbReference type="GeneID" id="81627471"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="311" mass="34570" checksum="9A1EE648ADFE2454" modified="2023-11-08" version="1">MLSLSPSTVSSSSLDTKDAESAKTIGSPESLSPVEAARDCNSHLPFEIPGAVVLSAPSISTLRQTANDELIGGDRNPLEVPYRLTLDTQHQQGVIRIIPSKAHERVTQSFSNKLVLKLFEIGINSDDYTMNSAARYYGNSCEKEADESLTPLGNPSEGNPSEDNDWPSLVIETGLSESEAQLRTDAYWWFSNSGYQVNMVILFHIQRSPERRVTLKLYHLRPTRITRGLQAEIEHSLLFNHTTPQTVSSIALRPHLAAKEIIITSRSVENAPLELEFESVMRRPPAPNTNERNIIFTAEDLATCCRYAIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WW63</accession>
    <name>A0A9W9WW63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_007520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787920.1">
        <property type="nucleotide sequence ID" value="XM_056937121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WW63"/>
    <dbReference type="GeneID" id="81627370"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5477376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="83" mass="9304" checksum="98449F73BBCED138" modified="2023-11-08" version="1">MEIKRKSDWGMDEMSGEAKIEGFAEILGVGVCSPIRKDLSEVESLFRSGKWTLTRKQADAGKRPVVCRVVCRRLAPLEAELHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1H9</accession>
    <name>A0A9W9X1H9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Lysophospholipase</fullName>
            <ecNumber evidence="3 10">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_006623</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the release of fatty acids from lysophospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the lysophospholipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3 10"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788159.1">
        <property type="nucleotide sequence ID" value="XM_056936224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1H9"/>
    <dbReference type="GeneID" id="81626473"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07203">
        <property type="entry name" value="cPLA2_Fungal_PLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000010">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF62">
        <property type="entry name" value="LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 9 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041015423" description="Lysophospholipase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="12">
        <location>
            <begin position="51"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5480729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="642" mass="69107" checksum="E9B36F2CCD346AC2" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2V0</accession>
    <name>A0A9W9X2V0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788670.1">
        <property type="nucleotide sequence ID" value="XM_056935746.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81625995"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="862"/>
        </location>
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            <begin position="7"/>
            <end position="18"/>
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            <begin position="45"/>
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            <end position="454"/>
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            <begin position="1016"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5482698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1297" mass="142484" checksum="99B7DA34566A21C2" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2X5</accession>
    <name>A0A9W9X2X5_9EURO</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="4" type="ORF">N7539_006344</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
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        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
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    <evidence type="ECO:0000313" key="5">
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9W9X360_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">N7539_006463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <strain evidence="2">IBT 30728</strain>
        </source>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
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            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5483017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X4V0</accession>
    <name>A0A9W9X4V0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentafunctional AROM polypeptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000007">
        <property type="protein sequence ID" value="KAJ5483856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056935658.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81625907"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050068">
        <property type="entry name" value="MurA_subfamily"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43783">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43783:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5483856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="756" mass="80966" checksum="75D8020BFCF7B5A9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X504</accession>
    <name>A0A9W9X504_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_005843</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789317.1">
        <property type="nucleotide sequence ID" value="XM_056935445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X504"/>
    <dbReference type="GeneID" id="81625694"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000015">
        <property type="entry name" value="Proteasome subunit alpha type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5484047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="246" mass="26842" checksum="82CEA919E08AD034" modified="2023-11-08" version="1">MFIARSEYDRGINTFSPEGRLFQVEYSLEAIKLGSTAIGVATSEGVILGVEKRVTSTLLEASSVEKIVEIDQHIGCAMSGLQADARNLVEHARVECQNHAFHYAEPLRVESTTQAICDLALRFGESGDDEGSVMSRPFGVALLIAGYDEDGPQLYHAEPSGTFYRYDAKAIGSGSEGAQAELQNEYHKSLTLAEAESLVLKTLKQVMEEKLDSKNVQLASVTKEKGFRIYNDEEMGRAVAQLGGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5J9</accession>
    <name>A0A9W9X5J9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CREG-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_004718</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789514.1">
        <property type="nucleotide sequence ID" value="XM_056934320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5J9"/>
    <dbReference type="GeneID" id="81624569"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273:SF1">
        <property type="entry name" value="ADL397C-AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040963597" description="CREG-like beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="CREG-like beta-barrel" evidence="3">
        <location>
            <begin position="65"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5484730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="313" mass="33782" checksum="DD55B68294B98FE7" modified="2023-11-08" version="1">MISALTVGLLALCSSTFTLTSASTIPPYPKPGQTVLKDVHSASSSEQDRPEEPGSHLLSRPSWFESALLARRLLAHSPSGVISTTFPDHISASSRTPSEVAGFPIGLREYIADCDSVLSTDLAHGGDEGDPTILALRVATSFRNIGAGSNLSLEIDWWDHLSDAGAVYPGLPPSPAALPRVTLFGHLETLSIADLSSSTNDAAARLERCFLESHPDAKWWLPGAVGSPHSSFWARLVVTQAYWIGGFGDVQQIGWINMTEWKGIRPERSLDGVGDGRGWKDVRLPGRSIMRHDGGNILGNFRCRYTARLLLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5S8</accession>
    <name>A0A9W9X5S8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Riboflavin kinase</fullName>
            <ecNumber evidence="6">2.7.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Flavin mononucleotide kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">N7539_004956</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>riboflavin + ATP = FMN + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the flavokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789752.1">
        <property type="nucleotide sequence ID" value="XM_056934558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5S8"/>
    <dbReference type="GeneID" id="81624807"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.30:FF:000008">
        <property type="entry name" value="Riboflavin kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="13 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="19">
        <location>
            <begin position="18"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ5484968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="208" mass="23288" checksum="C55D00416010DD33" modified="2023-11-08" version="1">MRPDTPRDPVAGPDAGPESPYPIRLSGPVIKGFGRGSKELGIPTANIPADDLSEEHPELTTGVYYGVVALDPRAQSHEDSRNDGEKSAETTILPAVLSIGYNPFYKNTVRSVEIHIMPQLTEPSPTAVAQPKFHRMPDFYGTKLNLLILGYIRPEYDYVSLDALIEDIRVDCEVARQSLLRDAYQRYIVDDDQGSNQVREDREWLKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X631</accession>
    <name>A0A9W9X631_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10 12">Alpha-glucuronidase</fullName>
            <ecNumber evidence="2 10 12">3.2.1.139</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">aguA</name>
        <name evidence="16" type="ORF">N7539_004935</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 12">Alpha-glucuronidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Releases 4-O-methylglucuronic acid from xylan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 12">
            <text>an alpha-D-glucuronoside + H2O = D-glucuronate + an alcohol</text>
            <dbReference type="Rhea" id="RHEA:20005"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:58899"/>
            <dbReference type="EC" id="3.2.1.139"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10 12">Belongs to the glycosyl hydrolase 67 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.139" evidence="2 10 12"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X631"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046559">
        <property type="term" value="F:alpha-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02795">
        <property type="entry name" value="CBM6-CBM35-CBM36_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1330.10">
        <property type="entry name" value="Alpha-glucuronidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037054">
        <property type="entry name" value="A-glucoronidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011395">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005154">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011099">
        <property type="entry name" value="Glyco_hydro_67_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011100">
        <property type="entry name" value="Glyco_hydro_67_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39207">
        <property type="entry name" value="ALPHA-GLUCURONIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39207:SF1">
        <property type="entry name" value="ALPHA-GLUCURONIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07477">
        <property type="entry name" value="Glyco_hydro_67C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07488">
        <property type="entry name" value="Glyco_hydro_67M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03648">
        <property type="entry name" value="Glyco_hydro_67N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029900">
        <property type="entry name" value="Alpha-glucuronds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="Alpha glucuronidase N-terminal" evidence="13">
        <location>
            <begin position="11"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 67 catalytic" evidence="15">
        <location>
            <begin position="147"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 67 C-terminal" evidence="14">
        <location>
            <begin position="471"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR029900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR029900-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5484947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="848" mass="94304" checksum="E139850F13E9912D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X641</accession>
    <name>A0A9W9X641_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prephenate dehydrogenase [NADP(+)]</fullName>
            <shortName evidence="2">PRDH</shortName>
            <ecNumber evidence="2">1.3.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_005166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>prephenate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21640"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.13" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789962.1">
        <property type="nucleotide sequence ID" value="XM_056934768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X641"/>
    <dbReference type="GeneID" id="81625017"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000002">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000004">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3660.10">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050812">
        <property type="entry name" value="Preph/Arog_dehydrog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012385">
        <property type="entry name" value="Prephenate_DH_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363:SF0">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036510">
        <property type="entry name" value="PDH_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR036510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5485178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="450" mass="50209" checksum="825930075619A990" modified="2023-11-08" version="1">MGRTRETASIGIIGMGDMGKMYAQRLSDAGWRPENFASLQEEFASRPLVTVFPNGHLVSRISDFILYSVEAGVIDRVVAQYGPSTKQGAIVGGQTSCKAPELAAFEKHLPSDVEIVSCHSLHGPKVNPKGQPLVSISLPCSYTACVDGDIDTKPQVLIKHRASDEALNFVNEILSSFGSQHVYLTGEMHDRITADTQAVTHAAFLSMGSAWQANRQFPWEISRWVGGIENVKINITLRIYSNKWHVYAGLAILNPSAKAQIRQYADSVTDLYKLMIGGQREELKRRVKAAGASVFKDGTEAQDLLLSDEVLDRFSLSNHTREKSPPNSHLSLLAIVDCWSQLGIVPYDHMICSTPLFRLWLGVTEYLFRNPDLLEEALDTAIDDNTFRSDDLEFTFAARAWSDCVSFGDFESYRDRFERIAQYFAPQFPEAAKLGDEMMKTILEKTEQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X675</accession>
    <name>A0A9W9X675_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789605.1">
        <property type="nucleotide sequence ID" value="XM_056934411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X675"/>
    <dbReference type="GeneID" id="81624660"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF6">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5484821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="305" mass="34062" checksum="173A88B8D367BB33" modified="2023-11-08" version="1">MGKRIIVTGGSGKAGQHIIAYLLDKGHDILNLDLAPLPDHLAKRVHTLRVDLTDSGQVYSVFTSHFHLTEPFREPLRLLPDAVIHLAGYSRNMIAPDNETFRGNTLSTYNVIEAACRLGINKIVTASSITVYGVSYAEGDVEYPSYPVDEEADANPMDTYAISKVCGERVARGFARRFGNDIYALRIGRVVAPEEYKQEMFKSYVESPNAWAPHAWSYTDARDLGQMCDLAVQKDGLGFQIFNAVNDEITNYTSSATEFLRRISPQVPFTGHMGPRDAPISNKKIKALLGFNQQHPWQLHYETEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X680</accession>
    <name>A0A9W9X680_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">mRNA-splicing protein ubp10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_005035</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789831.1">
        <property type="nucleotide sequence ID" value="XM_056934637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X680"/>
    <dbReference type="GeneID" id="81624886"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000068">
        <property type="entry name" value="U4/U6.U5 tri-snRNP-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="13">
        <location>
            <begin position="105"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="227"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5485047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="612" mass="68330" checksum="F8FA7137D5497E01" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6J0</accession>
    <name>A0A9W9X6J0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">YTM1</name>
        <name evidence="9" type="ORF">N7539_005047</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6J0"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000593">
        <property type="entry name" value="Ribosome biogenesis protein ytm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="8">
        <location>
            <begin position="16"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="169"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="217"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="290"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="377"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5485059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="486" mass="52200" checksum="6E535FD9AE958496" modified="2023-11-08" version="1">MDGETNSSSEPSQRQVRVQLVTQQEDIALPDSTGPILIPTALRRYALSTLVNNLLSTEKPVPFEFLINGTFLRTSIDEYLTDNGISAETTLEIEYVRALIPPLHIASFQHDDWVSATDVLSSTSPAASWASGATFSKGQERILSGSYDGLLRVWNMSSETIATSPVASDGGHTSSIKAAKFVSPNQIVSAGLDRTVRLWKYTEDEAFLGKITPQLELYGHKSGIESLAVHAPSNRLLTGSADHTVGFWSTKKADAPAAPESLLPNAARTSKRRKLNTSVSTPQRGPLALLSAHTGPVSAAIFDGKDSTVGYSASWDHSLRTWDLITSALVDTRTTAHSLLSLVHIQEHNLLAAGTSARHITLIDPRASATTVAAMTLRGHTNAVVSLARDPSSTYGLISGSHDGTCRIWDIRSTKNDKDGVVGESVYSIARKSLEEEGKADSKRVGGEGVKVFSVCWDQTVGIVSAGEDKRIQINRGEGVLSSNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6N6</accession>
    <name>A0A9W9X6N6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Importin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_005122</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789918.1">
        <property type="nucleotide sequence ID" value="XM_056934724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6N6"/>
    <dbReference type="GeneID" id="81624973"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000244">
        <property type="entry name" value="Nonsense-mediated mRNA decay protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="898"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="906"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5485134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1051" mass="119296" checksum="091E4B4357BCA020" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X723</accession>
    <name>A0A9W9X723_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_005547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790343.1">
        <property type="nucleotide sequence ID" value="XM_056935149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X723"/>
    <dbReference type="GeneID" id="81625398"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5485559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="163" mass="17588" checksum="F223171401D1E1CB" modified="2023-11-08" version="1">MTGGLQRLVLKAAFLEHRVSDPAALQRRDEMAASPILVSSCHNARLGHPLRITAVSAPLTFLMKAGDNLLQCSVACSSSRLADSRAPDFNLTGSSIGTFSYTIMLRSNGGGMWTMDRAMLPTDRPTELATSSFGTLLELYSGTEAVVHCWFLLEVETADQASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X725</accession>
    <name>A0A9W9X725_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_005470</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790266.1">
        <property type="nucleotide sequence ID" value="XM_056935072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X725"/>
    <dbReference type="GeneID" id="81625321"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="188"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="452"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="34"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5485482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="626" mass="69768" checksum="2A08D8BBA4F5DE81" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X766</accession>
    <name>A0A9W9X766_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_005550</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790346.1">
        <property type="nucleotide sequence ID" value="XM_056935152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X766"/>
    <dbReference type="GeneID" id="81625401"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF160">
        <property type="entry name" value="SAT4 FAMILY MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="14" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040751709" description="CFEM domain-containing protein" evidence="16">
        <location>
            <begin position="21"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="31"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5485562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="417" mass="45875" checksum="B797911FA3AA8B9E" modified="2023-11-08" version="1">MRVQGIVCVVGVLFATLTAGAKQEAPTLPTCALSCMKSSFSQTSCILTDQACLCTDTKYTTYLEKCVSANCTIRQSLGTATKKVTSAACGAPVRDRTKIVSYAGVGGGIVALIAFILRIVARFKCSTSIGMDDLTMTVTMCLVVTLSGLSVVLAEAGLGRDMWTIPADNITYILYIYFWDELIYLSILPLTKISILCFYLRIFPEPRFRYLTYIVIALNVGYLIAFILVSVFQCRPIQGAWLHWDGEGHYQCNNINAQGWTSAIFNMVLDIIVMLLPLKQLYHLKLSWKKKIYVMCMFGLGIFVTLVSILRLNSLIHFASTQNLTWDYVAVGYWSTIECDVGVICACLPAIRSLLRHAAPGVFGDTERNKSYGTSSHGRGNSRLDGSITVNAKGDNGQFYPLNNFGNSSEARLNQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7K5</accession>
    <name>A0A9W9X7K5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">F1F0 ATP synthase assembly protein Atp11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_005529</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790325.1">
        <property type="nucleotide sequence ID" value="XM_056935131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X7K5"/>
    <dbReference type="GeneID" id="81625380"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010591">
        <property type="entry name" value="ATP11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126:SF0">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126">
        <property type="entry name" value="CHAPERONE ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06644">
        <property type="entry name" value="ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5485541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="39490" checksum="D039068D0853D3F9" modified="2023-11-08" version="1">MASRRLSGFQPLLKGKSHLLRSQQRRWAQVHDVRFLATHHDPNHIMEKYRNKLDQKAKQEGLGSIEALKEAYSDKIQDLRRQAATVATPEPEPDAPIPRAKTTFTANTPPASHPPSSSSSTTGGASATEKAAREVSSSASPIKPLSTYIDVEKIRELPPKEIEALWRLRFANSSTTICAAIPLDTYLRIAEAARQNPQFILPLPRQAADQDMQTPDGTPAQTAAEIHFLQWAFHPPAEDFVATKKDTINNHTSTVIFTNLGAFKMHGSFAQPHTTVTHHLDLADDKGLVLMHGQVMPDRGVSTTEATWLVSSVQRFYDFGGQASGRKGELVRMFTRGDVENFKVEELMEETERIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XBT7</accession>
    <name>A0A9W9XBT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790543.1">
        <property type="nucleotide sequence ID" value="XM_056933002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XBT7"/>
    <dbReference type="GeneID" id="81623251"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5488510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="580" mass="63571" checksum="E7D40EB7A5E2EA03" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XC83</accession>
    <name>A0A9W9XC83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytosolic Fe-S cluster assembly factor nbp35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NBP35</name>
        <name evidence="12" type="ORF">N7539_003629</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XC83"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904564">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly scaffold complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000427">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03038">
        <property type="entry name" value="NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028601">
        <property type="entry name" value="NUBP1/Nbp35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF35">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="86"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5488739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="345" mass="36743" checksum="A108C99D39A069AD" modified="2023-11-08" version="1">MAPYVEKSAVEASLSAHTKRAPTNLVAPEPEHCPGPESEQAGQGDACAGCPNQQICASAPKGPDPDISVITERLSQIRHKILVLSGKGGVGKSTFTTLLAHAFAANPESTVGVMDTDICGPSIPRMMGVESETIHVSNAGWSPVWVTDNLGAMSVQFMLPNRDDAVIWRGPKKNGLIKQFLKDVDWGELDYLLIDTPPGTSDEHLSVNALLKESGVDGAVMVTTPQEVSLLDVRKEIDFCHKAGIKILGLVENMSGFVCPNCTHESQIFRKTTGGGRRLAKKMGIPYLGAVPLDPRVGMACDYGESFVDNFPDSPASKAIRRVVRAVGQAVGENPDDVLAESSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDG7</accession>
    <name>A0A9W9XDG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791305.1">
        <property type="nucleotide sequence ID" value="XM_056933764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDG7"/>
    <dbReference type="GeneID" id="81624013"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="60" mass="7129" checksum="7B9B90EE3CBA3279" modified="2023-11-08" version="1">MMDDKTLLKVDFKGKQKAQGFEPMDKSTEKNQDRQPKEKNANAPFHAPSLMIYRWYLRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDH5</accession>
    <name>A0A9W9XDH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_004101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791244.1">
        <property type="nucleotide sequence ID" value="XM_056933703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDH5"/>
    <dbReference type="GeneID" id="81623952"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5489211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="319" mass="35915" checksum="FF0C4128A95FBF84" modified="2023-11-08" version="1">MTAKAGQESQYHLSQTEIDHFMRHGYVRIPNCFTREKAAEWTADVWTRLGYSSTDKSTWAAERIHMPEHKWEPVQTFAPKAWAAICELLGGEDRVAVDSAVWNDAFIVNLGTPESEGNWTPAAELDNWHVDGDFFIHFLDSPEQGLLVIPLFSDIQEHAGGTMVCSDAIGKVAQHLYRHSEGVSPYMVPRGQPDDQTGAFYDTVLEQCHEFHEMTGKIGDVVLLHPLMLHSASVNSLRIPRIITNPPVSLKQPFNFDRPDPSQYSIVEKKTLHELGKPRLQGWKIRGGRAGVVPARLQAQEQMKQKELERLKTIAGAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDJ5</accession>
    <name>A0A9W9XDJ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_003657</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SRB8-11 complex, a regulatory module of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790800.1">
        <property type="nucleotide sequence ID" value="XM_056933259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDJ5"/>
    <dbReference type="GeneID" id="81623508"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000092">
        <property type="entry name" value="RNA polymerase II holoenzyme cyclin-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 12" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="13">
        <location>
            <begin position="53"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5488767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="303" mass="34502" checksum="68B09DB4CFD6C952" modified="2023-11-08" version="1">MAANYWASTQRRHWLFTREKLAEVRDRLRDQDKASHSQFPLPDQRLLNIYFNQQLIKLGKRMSTRQQAIATAQVYLKRFYTKNEIRQTNPYLVLTTAFYLACKMEECPQHIRFVVGEARGLYPEFITPDVAKLGECEFALISEMSSQLIVHHPYRTLSELQTELALSSDEVALAWSVINDHYLTDLPLLHPPHIIAVMAIIVAVVFKPSHPGNFGNSAQSALAGVMRDGGGMGMLAALSDKSGSGPPRVQNLVQWLAESEVDIKAVIECTQELLSLYEVWEQYNEKHCKELIGRMVRTKNLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDK7</accession>
    <name>A0A9W9XDK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_004222</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791365.1">
        <property type="nucleotide sequence ID" value="XM_056933824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDK7"/>
    <dbReference type="GeneID" id="81624073"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF103">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5489332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="53743" checksum="E00435E20C5057CA" modified="2023-11-08" version="1">MTEKQPEKHNRSLVQETTCQSVDQGTMEQQPAESTPYSAAAERKLVRRIDLMILPLMLVAYMMAYLDKQALSYAALMGLQKDLHLVGSQYSWTSGIFYFGYLFFSMLWAVVLTCHAATKNFTTMMVTRFLLGCTEASLSPGFTLITSLWYRTSEQPLRAGIWFCGNAISAILGNLIAVGILQIKEHLYPWQWLFIIFGLATLAWGLLMLLRLPDSPTNATFLTEEERAIAIERMRANKTGFKNTHIDRSQIAEAFTDIKTWLLAILILASNIPNGGFTTFNGLVLKGFGFDTFHTLLLGVPGGFIVFVFVLVSCTISSKVPNSRCLVIAAAITVSIIGSVMVYAGTSTGVRYAGLLLMGIYSCSMPVSLAMISSNVGGFTKRSSVSAIYFIMYCAGNIIGPQLFFAREAPKYQSGFLATIVCLAICLITALALFFYLRWENARRDRLSMTGRPAELSAPGDKQETGTSAPLVDVTDLKNLDFRYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDT0</accession>
    <name>A0A9W9XDT0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF1750-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_004327</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791470.1">
        <property type="nucleotide sequence ID" value="XM_056933929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDT0"/>
    <dbReference type="GeneID" id="81624178"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013859">
        <property type="entry name" value="Ssr4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046464">
        <property type="entry name" value="SWI-SNF_Ssr4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20497">
        <property type="entry name" value="SWI-SNF_Ssr4_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08549">
        <property type="entry name" value="SWI-SNF_Ssr4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 C-terminal" evidence="4">
        <location>
            <begin position="273"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 C-terminal" evidence="4">
        <location>
            <begin position="569"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="603"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="365"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="620"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5489437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="69780" checksum="12B631CE7BA25BFC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDT4</accession>
    <name>A0A9W9XDT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SAT3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_003913</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791056.1">
        <property type="nucleotide sequence ID" value="XM_056933515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDT4"/>
    <dbReference type="GeneID" id="81623764"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5489023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="304" mass="32252" checksum="05A2EAD764EF67C2" modified="2023-11-08" version="1">MAHLEASNLFSVKERVVVITGGGSGLGRIMARALAINGASKVFVLGRREDALRETAAQAPEGIVIPVKCDITSKESLESAYQAVAEQTTHVDILFANGGILGPLMRSPEAHADGTPPSLTELRDALFNVPMEEFTKVLNVNVTGTYYTVLAFLPLLEAANKKRPAPQEGVLTPPSAQVVITSSIAGFVRKVPFSYAYNASKASTNQLVKLLSTNLADYKIRVNGLVPGLYDSEMANNIFVAHGHTTGGVSEGSFPKEMIPLTRGGSEEDFAGLIVWLASNSAGYVNGNLLVTDGGRMSVVPNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDZ3</accession>
    <name>A0A9W9XDZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Exportin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_004466</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791609.1">
        <property type="nucleotide sequence ID" value="XM_056934068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDZ3"/>
    <dbReference type="GeneID" id="81624317"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000490">
        <property type="entry name" value="CRM1p Major karyopherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1045"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5489576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1072" mass="122717" checksum="F933D7B36EAF72D8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEF9</accession>
    <name>A0A9W9XEF9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_002322</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791884.1">
        <property type="nucleotide sequence ID" value="XM_056931925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEF9"/>
    <dbReference type="GeneID" id="81622174"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005685">
        <property type="entry name" value="PRK07483.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF2">
        <property type="entry name" value="AMINOTRANSFERASE, CLASS III (AFU_ORTHOLOGUE AFUA_1G16810)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5490755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="450" mass="48949" checksum="F12E930D746961AC" modified="2023-11-08" version="1">MSSAVLHRDTHFIPRKAVGGEGCYIFLEDGTKFLDSTGGAAVSCLGHGNEHVKQVVKAQIDQISYCHSAFFGTQATEDLATFLTESTGGKMSKLFVVSSGSEAFEAALKLARQYFLELPTPQPERTRFISRLPSYHGTTLGALGAGGHVQRRQPFEPLLAQNTSHVSPCYPYRGKKEGESDADYVARLAAELDAEFQRVGPEKVCAFVAEPIVGAALGCVPAVPGYFPAVKAVCEKYGALLILDEIMCGMGRCGTLHAWEQEGIVPDIQTIAKGLGGGYVPVSGILINDAVVQTMDKGTGQFRHGQTYQGHPVSCAAALAVQQTIKQQALLDNVRDMGHYLEQRLRQEFESHPHVGDIRGKGLFWGLEFVQDKTTKEPFDPKHRLAFHIQETGLKKEYAVSFYGSSGTVDGIRGDHVIIAPPYIVTKEEIDVVVDTLAKVLEVVLANFHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEN1</accession>
    <name>A0A9W9XEN1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_002436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791998.1">
        <property type="nucleotide sequence ID" value="XM_056932039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEN1"/>
    <dbReference type="GeneID" id="81622288"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF55">
        <property type="entry name" value="MAGNESIUM TRANSPORTER ALR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5490869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="239" mass="27582" checksum="0EEDF522E68E9928" modified="2023-11-08" version="1">MNHPGKETEKVAMVLFERFSFSSLEAHKTGCSDFNQPVWWIDIQDATEQDIRAVSHAFSIHPLTAEDVVIREPREKVDVWDDYYLICFQTLIHQSLQKQEQPEIQVSVALCILVFQCRAITSLSGIHVNRVRERIHGMHNPSILTSDWICYAMIDEIINSFESFARDAEREGEAIEDQIYTVRIDDAQILLPRVNVLRKKIAQITRYLSRKVDVLNGYVKCCQAPTSTQFSQMGSLFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFH4</accession>
    <name>A0A9W9XFH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_002821</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792383.1">
        <property type="nucleotide sequence ID" value="XM_056932424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFH4"/>
    <dbReference type="GeneID" id="81622673"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000010">
        <property type="entry name" value="Proteasome subunit beta type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 10 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5491254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="258" mass="28042" checksum="84AC1CBFD76EB336" modified="2023-11-08" version="1">MVSQHGVQGVLGEGKIELFVTPSFNQRRKLKVINQMGFMLICSTSRVEKSSMSHSARNFMAINFKDGVILGADSRTTTGAYIANRVTDKLTQVHDTIWCCRSGSAADTQAVADIVSYHLNMYGVVNDEAPSTQVAASLFQELCYENKDALSAGIIIAGYDPRHGGQVYSIPLGGSLHKQSFAIGGSGSTYIYGYTDAHWKENMTEEEGIDFVRSALQEAIKWDGSSGGVIRMVVLTNRGAVRHLYLPDTNYTGPGVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFR5</accession>
    <name>A0A9W9XFR5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General amino-acid permease GAP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_003002</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792564.1">
        <property type="nucleotide sequence ID" value="XM_056932605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFR5"/>
    <dbReference type="GeneID" id="81622854"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="84"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5491435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="587" mass="63085" checksum="E4BD2D802174EC3E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFX4</accession>
    <name>A0A9W9XFX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_002984</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792546.1">
        <property type="nucleotide sequence ID" value="XM_056932587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFX4"/>
    <dbReference type="GeneID" id="81622836"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5491417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="507" mass="55526" checksum="212826FC265CE5DA" modified="2023-11-08" version="1">MASSWCWSCLSRLRVTPTPRAILPPQSITPRVASASFHSSAVQYANPTKKKGALVTQKYRQGQTLRRKKKKTTERARPPAVGERKALRKRIVLSNPNALEVEGMQDLSAETMVDSRLRGSVLGLPLPMLDQLRAVQAFKPKQGWSIFRRPGTVLRRDTLEMGRLFEKISGEGSAPEKGKVVKKILTGLKGSGKTVHLLQAMAMGFLKKWVVISVPDARELVSGETSYTPLEGTSPLQYVQPNAVSALLTRTVEANRAVLSSLRVSQTHKALPGLKPSSTLEDLAKLGFQDVAIAWPAFQALWTELTATAAAPGMEKDFVPRPPMVVTVDGLAHWMKESAYRASDYSPIHAHDLVFVKHFLSLLQNGQASLKNGGMVLYATSTSNNPAIYTFEVALEQLAARQAGISPSSPDYPSPEAYSGADERVLELFKPTTGKEPQFELQTLGGLTRDEARGYMEYFARSGLLREEVNETWVGEKWSLSGGGIIGELEKLGRHVRSTAQPVPVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGS7</accession>
    <name>A0A9W9XGS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein mgr2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_001329</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792963.1">
        <property type="nucleotide sequence ID" value="XM_056930932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGS7"/>
    <dbReference type="GeneID" id="81621181"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5492583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="113" mass="11973" checksum="AEE89A7BA0D408C4" modified="2023-11-08" version="1">MPVVAAPPAGGPVGPSTFDKMKMGAMMGSTVGGIMGFIVGTVTIFQYGAGPNGVMRTLGKYMLGSGATFGLFMSIGSVIRTEGQHNDAWLRARGPPIMLPRQSPLRQMRQMRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHB4</accession>
    <name>A0A9W9XHB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulatory factor Sgt1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793412.1">
        <property type="nucleotide sequence ID" value="XM_056931381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHB4"/>
    <dbReference type="GeneID" id="81621630"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="68800" checksum="CAFF3F4828104401" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHR4</accession>
    <name>A0A9W9XHR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_001988</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793622.1">
        <property type="nucleotide sequence ID" value="XM_056931591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHR4"/>
    <dbReference type="GeneID" id="81621840"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="37"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5493242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="508" mass="56080" checksum="BE144CA92F41825F" modified="2023-11-08" version="1">MAPSTNLSPRVEELKVGPSKRHQNWLKDPGLRKLNLGIFCMFMSSAGTGYNGSLMNGLLVLPEFTMITGGLRPSILGLLIAATSLGAFCAFTPASYIADRLGRKWCVRVGASLVILSAFLQIFVKTHWAFFGCRVLAGAGVGTAQTAAPLLATEIAHHRQRQTATALYNACWALGSITSASVCFGTLSMSSHWSWRAACVIQAFFPIVQIIGLAFVPESPRWLISKGRNDEALAILIKYHANGDKEDEMVQHEFHQICETINIEALEPRSWGSFFSSRGDMHRLIICIMLGLMQEWAGNGIISYYLAPILASVGVTRAADQASVNLGLQFWNLLLSSAGAIASERYGRRPLWLVGTMIMLFFLCMMTIVAGVFQEMHIAAAGMAMIPMIFLFFSGFNIAYSPLFIAYAAEILPFPLRAKGMAIALTTDAVACFFNQYVNPVAFAALHWRYYLVYIGCLTWFLVTVYFLFPETKGRTLEEISMIFDRKDIVSDESSEVSQEIHTATEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI09</accession>
    <name>A0A9W9XI09_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domaingeneral substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_001485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793119.1">
        <property type="nucleotide sequence ID" value="XM_056931088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XI09"/>
    <dbReference type="GeneID" id="81621337"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF177">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="34"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5492739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="734" mass="78600" checksum="7BE2DCAC3FAB9CE5" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIG8</accession>
    <name>A0A9W9XIG8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Voltage-gated potassium channel subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_002260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793894.1">
        <property type="nucleotide sequence ID" value="XM_056931863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIG8"/>
    <dbReference type="GeneID" id="81622112"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF6">
        <property type="entry name" value="VIC POTASSIUM ION CHANNEL, BETA SUBUNIT (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5493514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="351" mass="39216" checksum="D96645C0BD93283D" modified="2023-11-08" version="1">MAWAEPRNTGMRYRRLGNSGLHVSVLGLGGWLTFGGHVDNEKTIACMKQAYDCGINFFDTAESYADGQSEIAMGQAIEQLGWKRNDIVISTKLNWGGANGEVLINNHGLSRKHIVEGLRSSLKRLNLEYVDIVYAHRPDRLTPMEETVRAFNHVIERGWAFYWGTSEWSADEIAEACGIARELRLIPPVVEQPQYNLLARERVEGEYQRLYSRFGLGLTVFSPIKMGLLSGKYNDSPDQPPAGSRFAVSNDKFSNMVRESMYGNDEWKQSIAKVIKLKPIAEQLGVTQSQLALAWCLKNEHVSSVITGASNPQQIVENVQALKALDKMTPEVMESIDDVVGKIDLAPARQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XKY3</accession>
    <name>A0A9W9XKY3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793909.1">
        <property type="nucleotide sequence ID" value="XM_056929616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XKY3"/>
    <dbReference type="GeneID" id="81619865"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5494896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="350" mass="37546" checksum="1311F77753FC473D" modified="2023-11-08" version="1">MATLTMTPPTRQPFANLDTPQMRSLMRSRLNRQTPQLGVFHSAKPLRSSFFIEDAENIAPSSHGSSGKRKRTLEDDDGISVDSPKPMKSFRMALSVRDMSFSPRLCTPAKLSLSTPKSAPVLKPAGRSPPPKSSLSARRSTIAKARPEPSRRAGVTRPFSLAKALSHGKIKAPAPPQPKGPDSWFFDIHVDSEQEEMTNLMQHSTGVLDISDDESKASPVDDRGKENVPPTESGLELAALPAAMSSATVVRNLAKIDDDRAPLGELNAADYYPDGCNAFSVEVVHDDEVSETAVPIKTSPLSQSPLASSVVTDAITSAMEDGTPNEGHDIGDVIHKVQEHSPVGADAAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XL25</accession>
    <name>A0A9W9XL25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793956.1">
        <property type="nucleotide sequence ID" value="XM_056929663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XL25"/>
    <dbReference type="GeneID" id="81619912"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5494943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="29635" checksum="CD66478A2A1E098E" modified="2023-11-08" version="1">MNATNIIHPQRGPRSDDPGLQVVPGYEKQVVSNDYPIYLYGPERPEKVDEEETKTPKTTYCGLRPAVFWTLLVIALLVVVGGAVGGGIGGTIASRHSAELSSQTSSSSPPISSTTPPTMSTSMLSTPHDVPTTLYTVTASNTSVLFPMTNTQSNPTATPVTSGTSGIADSPCPGKNLTTLAGSDGSLFTLLCAVDWPSGIQALSGKGTVHDLTRFTRYTLPSCIADCVDWNDDSSHTSKCKGIVYTANLTAAFGGGQDGNCFLKSAVGTYFPNSGLSMAAGIMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLA0</accession>
    <name>A0A9W9XLA0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_000175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794072.1">
        <property type="nucleotide sequence ID" value="XM_056929779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLA0"/>
    <dbReference type="GeneID" id="81620028"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001113">
        <property type="entry name" value="RNP domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="43"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="235"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="118"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5495059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="371" mass="38861" checksum="0F927E487123B332" modified="2023-11-08" version="1">MSAVDAVANTMAATTLNDTPKTNGTTAASQPTDAAAASADEGRRLYIGNLAYATTEEELKEFFKAYKIESTSIPVNPRTSRPVGYAFVDLATAHEATAAVENLSGKEILARKVSVQLARKPEPAEAKEGVTSGGEGASGNEGRKRTGGRGRGRGRARGRGGRAARGRTQDGQEPTETTTNAATTAPAATADATTVKDATSEKAPSVTEGAKPGKARAPRPQKQRGPPEDGIPSKTKVMVANLPYDLTEDKLKEIFAAYSPVSAKVALRPIPRFMIKKLQARNERRKTRGFGFVNLASEELQTKAVNEMNGKEIDGRTIAVKVAIDSPGKEDDVNAAADQYEQNSAPAQAASTAGQEENVAPADPAAPTTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM66</accession>
    <name>A0A9W9XM66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cellular morphogenesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_000638</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794535.1">
        <property type="nucleotide sequence ID" value="XM_056930242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XM66"/>
    <dbReference type="GeneID" id="81620491"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902929">
        <property type="term" value="C:plasma membrane of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024982">
        <property type="entry name" value="Rax2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048266">
        <property type="entry name" value="Rax2-like_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048265">
        <property type="entry name" value="Rax2-like_third"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778:SF2">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12768">
        <property type="entry name" value="Rax2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20842">
        <property type="entry name" value="Rax2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20843">
        <property type="entry name" value="Rax2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like second" evidence="3">
        <location>
            <begin position="219"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like third" evidence="4">
        <location>
            <begin position="379"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like C-terminal" evidence="2">
        <location>
            <begin position="873"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5495522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1202" mass="126932" checksum="21A2CF3923D10B6A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM99</accession>
    <name>A0A9W9XM99_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_000698</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794595.1">
        <property type="nucleotide sequence ID" value="XM_056930302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XM99"/>
    <dbReference type="GeneID" id="81620551"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5495582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="509" mass="55234" checksum="CF55839CD9EFA98F" modified="2023-11-08" version="1">MGGMTSEGSVVEKQGEPSMNADELRLAQMGHAQELKRHFSILSLIGLASTTTISWTGLGLGIVTEINAGGPGAIIYGFILVTVMQSFLGASLAEFVSSYPTEGGMYHWIAAVAPKRYSAFLSFLTGWLTVCGWIFTTASTNLIFAQVVQALYALYHPDLTFQAWETFVIYQILNALTAAVVLFGNAIIPALNRFSLFYLQIGWLAVLVTVVACAPTHRDSTFVFQTWINNTGWKNNGICFITGLVNPLYSLGGLDGVTHITEEMPNPSRNAPLAIAITLSIAFVTGLTYLVGLMFSVQDYAALSTTSTGLPLAELFHQVTQSAGGAFGLTFILFIALGPCVISSQLSTSRVLWAFARDGAMPFSHIWSRVSRRFGIPFNAQLLVASANAVLGCLYLGSSTAFNSMLGAAVTINNVAYLVPIATNMLTGRSNMHRGTFHMGKWGWLVNGITVCWLVFAITFFSFPYTMPLTVQNMNYTCVVVGGLPIFILLWWVVGSRQYKEKIAAAKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMA4</accession>
    <name>A0A9W9XMA4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_000296</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794193.1">
        <property type="nucleotide sequence ID" value="XM_056929900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMA4"/>
    <dbReference type="GeneID" id="81620149"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048630">
        <property type="entry name" value="Sec8_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20652">
        <property type="entry name" value="Sec8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="6">
        <location>
            <begin position="161"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec8 middle helical bundle" evidence="7">
        <location>
            <begin position="413"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="626"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5495180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1187" mass="131991" checksum="3D7F4E1558F59FD1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMV5</accession>
    <name>A0A9W9XMV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phomenoic acid biosynthesis cluster MFS-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794508.1">
        <property type="nucleotide sequence ID" value="XM_056930215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMV5"/>
    <dbReference type="GeneID" id="81620464"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="79" mass="8698" checksum="C94D3A790DC428E7" modified="2023-11-08" version="1">MKAGLPSVLVEPCTSSSNSQLSEKHDSSSEEVPKEEERTITGIKFQRLFLRSLTKLSEFRGCPSGTAPSILFKLTHFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN54</accession>
    <name>A0A9W9XN54_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mating-type switching protein swi10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_000776</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794673.1">
        <property type="nucleotide sequence ID" value="XM_056930380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN54"/>
    <dbReference type="GeneID" id="81620629"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000001">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000055">
        <property type="entry name" value="Mating-type switch/DNA repair protein Swi10/Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="8">
        <location>
            <begin position="53"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="249"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5495660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="327" mass="36015" checksum="2F790B5F39A0BE04" modified="2023-11-08" version="1">MDARSRDESLLQARAGASDGSTTSQPGIPTAGQPKVQQPKPQALPNRSGPSAILVSTRQKGNPILNHIKLLPWEFADIPADYVVGTTTCALFLSLKYHRLHPEYIYSRIKLLAGKYNLRIVLVMVDIPNHEDPLRELSKTSIINNLTLMLCWSAPEAAHYLELFKSSEHAQPTAIRTQQAQSYKESLVEFVTTPRSINKSDAASLISTFGSLQNAVNAQPEQISAVPGWGEKKVQQWCNAVREDFRVETAKKASAPVSRATTQKPRSVRQDQVAMAEDEDEAVLRSVMEESRRMAAAEEESRNSSRPTEQLDDGIAAALAKLRESGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJC4</accession>
    <name>A0A9X0BJC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exo-beta-D-glucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_008871</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785843.1">
        <property type="nucleotide sequence ID" value="XM_056938466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJC4"/>
    <dbReference type="GeneID" id="81628716"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043534">
        <property type="entry name" value="EBDG/EBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041351">
        <property type="entry name" value="Ig_GlcNase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43536">
        <property type="entry name" value="MANNOSYLGLYCOPROTEIN ENDO-BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43536:SF1">
        <property type="entry name" value="MANNOSYLGLYCOPROTEIN ENDO-BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18368">
        <property type="entry name" value="Ig_GlcNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040746260" evidence="4">
        <location>
            <begin position="20"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="7">
        <location>
            <begin position="61"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="5">
        <location>
            <begin position="222"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Exo-beta-D-glucosaminidase Ig-fold" evidence="6">
        <location>
            <begin position="778"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5469253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="898" mass="100998" checksum="5C4605E8D33B2AAC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJD1</accession>
    <name>A0A9X0BJD1_9EURO</name>
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        </recommendedName>
    </protein>
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        <name evidence="12" type="ORF">N7539_009063</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
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    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="GeneID" id="81628908"/>
    <dbReference type="Proteomes" id="UP001148312">
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
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        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0802">TPR repeat</keyword>
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            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040979297" description="Tetratricopeptide repeat and J domain-containing co-chaperone DNJ1" evidence="10">
        <location>
            <begin position="21"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
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        <location>
            <begin position="389"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="447"/>
            <end position="512"/>
        </location>
    </feature>
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        <location>
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            <end position="137"/>
        </location>
    </feature>
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            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
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            <end position="512"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5469445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="512" mass="57083" checksum="8F9F3256293FB5C6" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BMW5</accession>
    <name>A0A9X0BMW5_9EURO</name>
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        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001148312">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800">
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    </dbReference>
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        <property type="entry name" value="FER-1-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5475076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="600" mass="67880" checksum="58313A3FC81A651B" modified="2023-11-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BN60</accession>
    <name>A0A9X0BN60_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786776.1">
        <property type="nucleotide sequence ID" value="XM_056937684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BN60"/>
    <dbReference type="GeneID" id="81627934"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5475018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="85" mass="9659" checksum="BA05303CB24EF023" modified="2023-11-08" version="1">MLAKEKETDILDELSNHAQRVKLFNHPSQHIHVIKYLTAHPPGLESTEEIYVADQEDWVHGSFNVCILIHIGGHNAGGRKERPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNV1</accession>
    <name>A0A9X0BNV1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_007904</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787370.1">
        <property type="nucleotide sequence ID" value="XM_056937505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNV1"/>
    <dbReference type="GeneID" id="81627754"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF140">
        <property type="entry name" value="ATPASE, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="31"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5475617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="376" mass="41809" checksum="50475B24F9480FC8" modified="2023-11-08" version="1">MTMQPMPDGRSKAIFIVTTVFLGLSFIAVCLRCFVRLKLVKAFGWDDCLMVFAMLLNILFALCGITGAFYGMGQRSLALMQRGTMETAMFWWWLGQTSYVWVCAVAKISIAVALLRLTVIRIHTLILWGVIAVTTVVGLVFWLMLTLQCQPISFFWQQVRLEIDPTSPVHGHCLNLDIIIDMAYVYSVTATLCDLTLGLLPIFLVWNLHMNVRTKAALAGILGMGCVASAAVIVRIPFLHDYKDPDFLYATTDISIWSNVEASLGIAAGSLVTLRPLFRWFRDTSYGGSRSKRTGGSMPLSSVNALRSDHSTPRYWRPDLDPEDTRAVVTTIPTSTVKNGSRTSSQEDLNPKNNDGGTFFQGVNVHKTFYVSGNEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNV5</accession>
    <name>A0A9X0BNV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787385.1">
        <property type="nucleotide sequence ID" value="XM_056937520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNV5"/>
    <dbReference type="GeneID" id="81627769"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="90" mass="10043" checksum="039A691B3B4B1182" modified="2023-11-08" version="1">MGTEDEYLVTVGSNEKAPDPKLLSQEKKLAVEIVRRWLGLCERRPRPWICDLLCCSGRSHKSAKPSLRTGATRPKEGPSRVEPKENNGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNW6</accession>
    <name>A0A9X0BNW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="16">1.3.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">N7539_007166</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="16"/>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787566.1">
        <property type="nucleotide sequence ID" value="XM_056936767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNW6"/>
    <dbReference type="GeneID" id="81627016"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000003">
        <property type="entry name" value="C-24(28) sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562:SF2">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Dienelactone hydrolase" evidence="20">
        <location>
            <begin position="547"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ5477022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="763" mass="87092" checksum="0942E673E65BC684" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSI6</accession>
    <name>A0A9X0BSI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Small GTPase superfamilyRas type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_006696</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788232.1">
        <property type="nucleotide sequence ID" value="XM_056936297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSI6"/>
    <dbReference type="GeneID" id="81626546"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000464">
        <property type="entry name" value="GTP-binding protein ypt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5480802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="218" mass="23623" checksum="56C9A07A7C57B9B1" modified="2023-11-08" version="1">MASRPAAGARPGAKFAQFKLVLLGESAVGKSSLVLRFVKDQFDDYRESTIGAAFLTQTISLDDSTTVKFEIWDTAGQERYKSLAPMYYRNANCAVVVYDITQASSLDKAKSWVKELQRQANENIVIALAGNKLDLVTESPDKRAIQTADAEAYAREAGLLFFETSAKSSTNVRELFTAIAKKLPLDQAGPRNLRAAPRPGVDLRPEAPGTQGAGACNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSU3</accession>
    <name>A0A9X0BSU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Malate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788758.1">
        <property type="nucleotide sequence ID" value="XM_056935834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSU3"/>
    <dbReference type="GeneID" id="81626083"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF1">
        <property type="entry name" value="CONSERVED FUNGAL PROTEIN (AFU_ORTHOLOGUE AFUA_1G14230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040828349" description="Malate dehydrogenase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5482786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="26576" checksum="41859F3ABA324D3B" modified="2023-11-08" version="1">MRIVHYLFCWLAISLVETTTAIPDPLRFTTIFSSASKQLQSISLGNCSLTGISPPLNDTKKSLPTPSPGLDLKFIALGRGTQNYSCTPSPSSQDATKDEKPVAVGAVATLFDASCIAATSLSLLHELPSIMGRAPLGPLALITELLGDMTNSSSLILGEHYFNAAGEPTFNLTMSGSDAWAISKKDASVPAPRRVKVKNACPEKGQDVAWLKLDRKQGNLIKEVYRVVTFQGSPPPRALDRMRQFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSU9</accession>
    <name>A0A9X0BSU9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="10">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_006348</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the conserved oligomeric Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the COG6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788874.1">
        <property type="nucleotide sequence ID" value="XM_056935950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSU9"/>
    <dbReference type="GeneID" id="81626199"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="12">
        <location>
            <begin position="56"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="13">
        <location>
            <begin position="200"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="702"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="709"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5482902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="753" mass="83207" checksum="8100F821ADECECDC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BU95</accession>
    <name>A0A9X0BU95_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 13">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">N7539_004906</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="14">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 13"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789702.1">
        <property type="nucleotide sequence ID" value="XM_056934508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BU95"/>
    <dbReference type="GeneID" id="81624757"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000027">
        <property type="entry name" value="Probable mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.110:FF:000003">
        <property type="entry name" value="Probable mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="16">
        <location>
            <begin position="15"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="18">
        <location>
            <begin position="394"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="17">
        <location>
            <begin position="661"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="849"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ5484918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1174" mass="130501" checksum="C747008CAF5F8E8E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUA6</accession>
    <name>A0A9X0BUA6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_004952</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789748.1">
        <property type="nucleotide sequence ID" value="XM_056934554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUA6"/>
    <dbReference type="GeneID" id="81624803"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000040">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="365"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="897"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="937"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="978"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1008"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="35"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5484964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1050" mass="112916" checksum="3F267BB14C1ADEB4" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUC6</accession>
    <name>A0A9X0BUC6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789299.1">
        <property type="nucleotide sequence ID" value="XM_056935427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUC6"/>
    <dbReference type="GeneID" id="81625676"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="65"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5484029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="529" mass="60432" checksum="684400546BC57BFE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUI5</accession>
    <name>A0A9X0BUI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_004864</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789660.1">
        <property type="nucleotide sequence ID" value="XM_056934466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUI5"/>
    <dbReference type="GeneID" id="81624715"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5484876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="268" mass="29352" checksum="E6F7E0B63D6FE703" modified="2023-11-08" version="1" fragment="single">FSHLCEGPKMTGEIIPGRELVGIIIGAVVLFSLISIVPILIMWHHRRRQASRAGGGVEAPDESPIEQWIEGQNAGSDVAQQSQALCWDFWGTRYDVMRGSPKARWWTVCPTAPRQRSGCLGTALGASGHEQPPPVLATPIQSWQHPSIGKGPTLDHMAINFGVSWKKLIGFSSPICLSSLSSTSGLLSPEPARLPHNHRKPSDSSGSTAFSRADLDTEKGGRRDSAVVVLNRCHHVFHKACLASWFEYRRYRCPICQTSYSPGQAGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUJ5</accession>
    <name>A0A9X0BUJ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_004713</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789509.1">
        <property type="nucleotide sequence ID" value="XM_056934315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUJ5"/>
    <dbReference type="GeneID" id="81624564"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48192">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48192:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5484725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="352" mass="37986" checksum="194FD08B3A80D3C2" modified="2023-11-08" version="1">MEASSADKKRNKLGYHRTSVACVHCRRRKIRCLVSADDAQGRCENCIRLRKECQFFPVDQQPPIEKKSRPSSGMDAGSAPSATTPMSLPSSPNSMNPESTEPYYSYNSMSMNVSTSEMAVFNPGAFAPTQMSSFTPDRHGPTEDFSRMTAMEGTPSWDDFTTMSDQQMLATGIAPGKSQMMGMTPQHWDSAAVPAAMSPNSPLSCASPMAGHVQPMNPGPAGYAMHPDGSVWTAPPPPSRAMSYPPQEPGATFSSHFQPPMGQDLKRRMTTPANPTASHATSGSSYSMQMPPGGVPYPNQAGEMDFVQWQQMNAMSGGMNAVPYPMYTGDMSQQQFIPHPMGHPGAPRTSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUP2</accession>
    <name>A0A9X0BUP2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2H2 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_004833</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789629.1">
        <property type="nucleotide sequence ID" value="XM_056934435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUP2"/>
    <dbReference type="GeneID" id="81624684"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF8">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5484845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="65" mass="7717" checksum="D7E3847530503F42" modified="2023-11-08" version="1">MKPAEKHFRCTICQRGFTRIDHLKRHHLRHSGLKPYSCVFCNESFARWSVAKDASIKISPTERFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUS9</accession>
    <name>A0A9X0BUS9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790288.1">
        <property type="nucleotide sequence ID" value="XM_056935094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUS9"/>
    <dbReference type="GeneID" id="81625343"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="420" mass="45176" checksum="B036D98F3F76900C" modified="2023-11-08" version="1">MMEEESAMVQPLGVAPSVSPAAGLVATSQSDAAPMSHAVPPAAVTQTGSAACVGDAINAPDRLVEIKAEEDELLSISSESFSETSSIDIPDSSPELESGMHAEHEETPSTALARATSPAVQSMAGAAQSTTLSRRDDAPHNTAHDQTVATKDAKGNPDHKVFRTELDQLLLAMTIWRDVDWRQDPRPCPNKQKYRAAFTQQVGRVVPSDRTCSGCRAGNGPFKSCCVVVPAGTPLFRGACANCAFLQNGTSCSLRSGPNPLASFVNDALPKRAPRRAVPLEARETQTQPKKARRNSNQSTRKGVTNHQINSGGEDEYSVQNGEETTNSPENCQGTDTKSTSRFFKNAWLTSPLGDPAVWAKDGDFSATREALRSIPAMMESLNRDQAVLEKYLEDHDQLTTPPPPNIEEDDTENPFLAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUZ5</accession>
    <name>A0A9X0BUZ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_005435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790231.1">
        <property type="nucleotide sequence ID" value="XM_056935037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUZ5"/>
    <dbReference type="GeneID" id="81625286"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF15">
        <property type="entry name" value="INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5485447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="39509" checksum="A1E9ACA11F660010" modified="2023-11-08" version="1">MARGRLRLFLALVCVSVLVFLSAAHIQRLYQLLRMPFIWSGAAVDATISQQRDQFDLTFASYPANYSVRDDDHRALIPARIHHIHLGPNPPKPEWLAARSDCLKQHESWEFFLWNDENASQFVEANYPHLYEMWRNYPFVVQRVDALRYMTLKTYGGAVLDFDLACKRSMEPLRRFEFVAPAAHPAGFSIGMMLASPNNTFVNSMVESLPRFNHVFPLLPYVTVMFSTGCHYASTIFTLQKERSNYRILSGTTDKPRLHMLNGYVNTPLFRHLGSSSWHEGDARLILLLKHTDPKYIALAAFVAITVLVSSIWCMCMIRYRLLSRRDVESLARVSPNKSSCKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BV13</accession>
    <name>A0A9X0BV13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_005404</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790200.1">
        <property type="nucleotide sequence ID" value="XM_056935006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BV13"/>
    <dbReference type="GeneID" id="81625255"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5485416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="735" mass="81159" checksum="48AE028FADB92D31" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BV95</accession>
    <name>A0A9X0BV95_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Allophanate hydrolase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790455.1">
        <property type="nucleotide sequence ID" value="XM_056935261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BV95"/>
    <dbReference type="GeneID" id="81625510"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053844">
        <property type="entry name" value="AH_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21986">
        <property type="entry name" value="AH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allophanate hydrolase C-terminal" evidence="2">
        <location>
            <begin position="94"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5485671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="226" mass="24169" checksum="9553AF2F73A1E131" modified="2023-11-08" version="1">MSTRRTENVISRGPPALNPSARSARSARRIKTQALVSETISLKSSTVAKLLCNATGHPSTVPDLSTDYTIYRLAKIDEALRPAMTAPASAENMLLAVVGAHLSGFPLNRDLLSRGATLDLVTTTAKCYKLYALPTQGAVPKPGLQRVAEGGNSIEVEVWRMPLSLMGSFLSTVAPPLGIGSIEMIDGRWVHGFICEPIGFKNAVDITAFKGWRPYIQSLSSSGSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXD4</accession>
    <name>A0A9X0BXD4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_003571</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790714.1">
        <property type="nucleotide sequence ID" value="XM_056933173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXD4"/>
    <dbReference type="GeneID" id="81623422"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990625">
        <property type="term" value="P:negative regulation of cytoplasmic translational initiation in response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000787">
        <property type="entry name" value="Protein kinase, putative (AFU_orthologue AFUA_2G16620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF195">
        <property type="entry name" value="KINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16620)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="286"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="427"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5488681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="773" mass="86037" checksum="F37C2083BB8B26D5" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXJ3</accession>
    <name>A0A9X0BXJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formyltetrahydrofolate deformylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_003439</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790582.1">
        <property type="nucleotide sequence ID" value="XM_056933041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXJ3"/>
    <dbReference type="GeneID" id="81623290"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04875">
        <property type="entry name" value="ACT_F4HF-DF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08648">
        <property type="entry name" value="FMT_core_Formyl-FH4-Hydrolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01927">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041729">
        <property type="entry name" value="Formyl-FH4-Hydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044074">
        <property type="entry name" value="PurU_ACT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004684">
        <property type="entry name" value="PRK06027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00655">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="FORMYLTETRAHYDROFOLATE DEFORMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706:SF1">
        <property type="entry name" value="FORMYLTETRAHYDROFOLATE DEFORMYLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036480">
        <property type="entry name" value="FormyFH4_hydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="7"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5488549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="288" mass="31984" checksum="615C475929805860" modified="2023-11-08" version="1">MAPSSFILTLSGPDRPGIVHAVTAFLVQHNLNIVDSSQFGDLTSKRFFMRVQFVPAVATDEVPELEKLCAAFEPTAQSFSMEFEIHPTAQKPRVMIMVSKIGHCLNDLLFRQSTGQLNIEVPLIVSNHPDFAALAATYNIPFLHLPVTADTKAQQETRVLELVQEYKIDLIVLARYMQVLSPKLCEAMSGRIINIHHSFLPSFKGAKPYHQAYDRGVKIIGATAHFVTSDLDEGPIIEQNVVRVNHSMSPKELTHAGSNVESNVLATAVKYVTERRVLLNGHKTVVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXL3</accession>
    <name>A0A9X0BXL3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycerophosphocholine phosphodiesterase Gde1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003796</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790939.1">
        <property type="nucleotide sequence ID" value="XM_056933398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXL3"/>
    <dbReference type="GeneID" id="81623647"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047389">
        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08606">
        <property type="entry name" value="GDPD_YPL110cp_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14484">
        <property type="entry name" value="SPX_GDE1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="6">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="463"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="496"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="534"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="7">
        <location>
            <begin position="821"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="589"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5488906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1193" mass="131932" checksum="E5B50771D72A9EAC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXR8</accession>
    <name>A0A9X0BXR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_003976</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EME1/MMS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791119.1">
        <property type="nucleotide sequence ID" value="XM_056933578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXR8"/>
    <dbReference type="GeneID" id="81623827"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20085">
        <property type="entry name" value="XPF_nuclease_Mms4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033310">
        <property type="entry name" value="Mms4/EME1/EME2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047521">
        <property type="entry name" value="XPF_nuclease_EME1_ascomycetes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077:SF5">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MMS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077">
        <property type="entry name" value="EME1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="15">
        <location>
            <begin position="337"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="480"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5489086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="643" mass="71020" checksum="6D70BE38E3477280" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYR1</accession>
    <name>A0A9X0BYR1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Potassium channel tetramerisation-type BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791853.1">
        <property type="nucleotide sequence ID" value="XM_056931894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYR1"/>
    <dbReference type="GeneID" id="81622143"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31758">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN YLR108C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31758:SF2">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN YLR108C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="2">
        <location>
            <begin position="30"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5490724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="435" mass="48438" checksum="3AE3F0B7F998958F" modified="2023-11-08" version="1">MAADSSNASTPASTGKASACSLPPDKVFSIQIGSELFRLSGASIASDAPSYFSRFFEEQLRFVDSANVRALYIDRDPTTFQDIARHLQGYHVQPRDGTQFVKLFADAQFYTLPRLMSQLFESEIFIQIGDRHFQIPRDIFSSPGDSPNFFTLGFGAFFASPTEVFPGLDRVGLLRPPAIVPPSVPNRSAEVFAELLHLLRGYPLHIRNAEHRAELLRDCRYFHLRGLEQKLIPHRIDYNPYRGRTEIVVRLEDVRPSGVQYKPDPTGRPGAGLIMYARPFVDEVPADLVLEIPDASTIVNRRHCRADFLGLTKSRVVSLLQVIAKKMNLANGHFDASSPLGIRWDRATDLTVDGESNPAGFTLSPSDAGLDTPPAKRARTDGASDANAEILLVRTGQWRLGIEEDSNGTHKAVLVAIKLDIWTESRVRNQHQQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYZ6</accession>
    <name>A0A9X0BYZ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_004652</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Binds to F-actin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791795.1">
        <property type="nucleotide sequence ID" value="XM_056934254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYZ6"/>
    <dbReference type="GeneID" id="81624503"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000197">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="11">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="135"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="411"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5489762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="610" mass="66854" checksum="D942AFD3084F9107" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ63</accession>
    <name>A0A9X0BZ63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791986.1">
        <property type="nucleotide sequence ID" value="XM_056932027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ63"/>
    <dbReference type="GeneID" id="81622276"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF52">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="74"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5490857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="313" mass="34225" checksum="9D5942D065FC5570" modified="2023-11-08" version="1">MKTIQEMLAEKDGHSDSQSVRYLGTVEAYDKWAEVYDTDGNFLQRLDTMEMKRILPRFLECVYARFHDQPTRSERMALLDLGCGTGRNTIQLLNALAVQEQEETTSKPDGPPVPNVHVIGLDASPGMLKVARSAIDEAMGAGGAPANPRYTGPKVVLGTIDLLLQPAALRTQLPPLLRDTGAAGVICTLVLEHAPLRQFFQATSATMCPGGYLLLTNMHADMGLRSQAGFTDPQSGIKIRPTSYCHSIEEIVSAAEAAGFQMEDIFRQEASNGGVRERAIDEDLAGELGPRARKWIGITVWFGVCFSKKTSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ64</accession>
    <name>A0A9X0BZ64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_002756</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792318.1">
        <property type="nucleotide sequence ID" value="XM_056932359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ64"/>
    <dbReference type="GeneID" id="81622608"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000474">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF13">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="118"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5491189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="619" mass="68725" checksum="E9AC603E9B97F21D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZD2</accession>
    <name>A0A9X0BZD2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine-proline rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792705.1">
        <property type="nucleotide sequence ID" value="XM_056932746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZD2"/>
    <dbReference type="GeneID" id="81622995"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5491576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="157" mass="18359" checksum="DB6FECF103A9DBB4" modified="2023-11-08" version="1" fragment="single">ELNSAINPINFSVDKLRLVAVDYLRVLDADTKSPYLSPVTKRIRYILLYFNYKELCNHPKNYYPTPLSKPYTSYTTRVYLIPGRVAVIRLLYTISDEKTRPGTIYIFKNLEPIVKLLIFREITYDLRKVLFDKDIGLLRPKDIAAILKDDTRALAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZF8</accession>
    <name>A0A9X0BZF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_003322</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792883.1">
        <property type="nucleotide sequence ID" value="XM_056932924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZF8"/>
    <dbReference type="GeneID" id="81623173"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00567">
        <property type="entry name" value="ACAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000014">
        <property type="entry name" value="Probable acyl-CoA dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <end position="140"/>
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            <end position="244"/>
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            <begin position="258"/>
            <end position="410"/>
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    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5491755.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="418" mass="45762" checksum="E0999B4424F06D0A" modified="2023-11-08" version="1">MDVLSQQSISSCRQSSLDVRAAHLKLFNTNSLRFMKRSNKYVRISQTHIGKSATSKKKDPKEFHAALARDGWLGIALPEELGGAGLGISEATMMMQTITQSGAGMAGAQAIHANVYATQPLAKFGTKEQLETTIPNIINGTWRTCFGVTEPNTGLETLKLKTVATRTENGYSISGQKIWITCAQVASKMILLARTTPLEEVKKSSEGLSLFCIDLERNQPGLEMRKIKKMGGRAVDANEVFFDNYTIPAETLIGEESQGFKIILHGMNAERCLLAGEALGLGYAALEKAAQYAKERIVFGRPIGQNQGVAHPLADAYMKLEAAKLATYHAARLYDSNDDSVPFHAVGVACNSAKYLAAEAAFTACERAVLTHGGMGYAMEYDVERYLRECFVPRIAPVSREMILNYVSEKVLELPRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9X0BZJ5_9EURO</name>
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        </submittedName>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
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    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
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                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
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            </authorList>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9X0C060_9EURO</name>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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            <dbReference type="EMBL" id="KAJ5492654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="155" mass="17413" checksum="05CCC380AC212629" modified="2023-11-08" version="1">MKILENLSEHDYQVNIEENKESGRRSLASAKYLCSDPKSRTRKALMRIYAQVPHGKTEMHDTATRSQQATTFEPLELIAYRDLTERGSSETPGLLGYKTGKQDRSGLVPGGFMIWLVWEIVPGLRLGDGNGADAFWALESDERERVRMALINGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0B1</accession>
    <name>A0A9X0C0B1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spc7 kinetochore protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_001535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
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            <strain evidence="4">IBT 30728</strain>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">IBT 30728</strain>
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    </reference>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_056931138.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040850">
        <property type="entry name" value="Knl1_RWD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033338">
        <property type="entry name" value="Spc105/Spc7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013253">
        <property type="entry name" value="Spc7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18210">
        <property type="entry name" value="Knl1_RWD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15402">
        <property type="entry name" value="MELT_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08317">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00787">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01315">
        <property type="entry name" value="Spc7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="964"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="993"/>
            <end position="1014"/>
        </location>
    </feature>
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            <end position="1215"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5492789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1501" mass="165374" checksum="8FF628ECBB075A6F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0P0</accession>
    <name>A0A9X0C0P0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_002076</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056931679.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF8">
        <property type="entry name" value="PERMEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5493330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="299" mass="31748" checksum="9F1956480FC950B2" modified="2023-11-08" version="1">MGATNNSIASNFFLGMANVVYPAYIIERWHTVLLAYCVAFLSAGVNLWVSYLLHKISKFILIWNVPSFVIITVTLLATTSTITSSPYRLCFKTSKDTAGLGTAVTAIVGILQACFGMCCYDGPSHMTEEMNSATTEAPKTIILAVCLGTVTGFAFSLTLCFCIGDIAATAQSSTGVPVIQIMDDSTGSKVATCILASLIAVIVTVAGVNILAEGSRSTFAFARDHGLPFSPTCSKVERKSQVPVNAVFLTLAVQLALGAIEFGTVTGLPTVVSISTAGFWKYHLFFLCPANPYPSIRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C1Z5</accession>
    <name>A0A9X0C1Z5_9EURO</name>
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        <recommendedName>
            <fullName evidence="2">5'-3' DNA helicase ZGRF1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056929833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C1Z5"/>
    <dbReference type="GeneID" id="81620082"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052800">
        <property type="entry name" value="DNA_Repair_Helicase_ZGRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018838">
        <property type="entry name" value="ZGRF1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28535:SF1">
        <property type="entry name" value="PROTEIN ZGRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28535">
        <property type="entry name" value="ZINC FINGER GRF-TYPE CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10382">
        <property type="entry name" value="ZGRF1-like_N"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="26"/>
            <end position="106"/>
        </location>
    </feature>
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        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="466"/>
        </location>
    </feature>
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        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="601" mass="64993" checksum="6D29BA30765C0FEE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C299</accession>
    <name>A0A9X0C299_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arylsulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_056929655.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF33">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5494935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="561" mass="62904" checksum="AEB691EDB9459D98" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2P4</accession>
    <name>A0A9X0C2P4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794699.1">
        <property type="nucleotide sequence ID" value="XM_056930406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2P4"/>
    <dbReference type="GeneID" id="81620655"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="140" mass="15011" checksum="688C18F6909C0626" modified="2023-11-08" version="1">MAMPKKCTELDGHTEFLNHGKPLAGSWYRTELESLKYRVLCSCTVPITSTIASGRGVSRDRITEIRSVPALKHESDSFNGSPNNSLNGSLNGSLNGSLNGSLNGSLDGSLNGSLDGSPHDGFYENFNDILNDYPNDCSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2R6</accession>
    <name>A0A9X0C2R6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arf GTPase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_000862</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794759.1">
        <property type="nucleotide sequence ID" value="XM_056930466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2R6"/>
    <dbReference type="GeneID" id="81620715"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000010">
        <property type="entry name" value="Stromal membrane-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="14"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="402"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5495746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="576" mass="59951" checksum="3EDE0CD9764D3CAE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2X6</accession>
    <name>A0A9X0C2X6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-linked oxidoreductase sor8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_001042</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794939.1">
        <property type="nucleotide sequence ID" value="XM_056930646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2X6"/>
    <dbReference type="GeneID" id="81620895"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040838488" evidence="3">
        <location>
            <begin position="21"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="115"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5495926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="563" mass="61263" checksum="5FC5EEA044F20C70" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKM4</accession>
    <name>A0A9W9WKM4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">16 kDa allergen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785820.1">
        <property type="nucleotide sequence ID" value="XM_056938443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKM4"/>
    <dbReference type="GeneID" id="81628693"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040872570" description="16 kDa allergen" evidence="1">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5469230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="15914" checksum="B005C67CA891A518" modified="2023-11-08" version="1">MKATLISFGALVGLAAAQNAIVNNHCDSTVYVQSFPYDGSAPGPLTAVPKGGTFSEKFRPSGSTVKIGKLKTLQAPLFFGYSFSSNPDYAYYEFSTQFGNPFAAQPNSLSPGEGCEAFDCAANDAACYSTPAHKKVYGCPQPVDLTADLCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKT0</accession>
    <name>A0A9W9WKT0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_008939</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785911.1">
        <property type="nucleotide sequence ID" value="XM_056938534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKT0"/>
    <dbReference type="GeneID" id="81628784"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF22">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="213"/>
            <end position="235"/>
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    </feature>
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            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
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        <location>
            <begin position="291"/>
            <end position="311"/>
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        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="393"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5469321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="587" mass="64597" checksum="268C19D70A459D3B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLA7</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">N7539_009115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
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        <location>
            <begin position="31"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5469497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="84" mass="9154" checksum="776607DAEFA857FC" modified="2023-11-08" version="1">MAMAMAMHRPRPVILGIFCFLLAGLLSGTADWHSGSSALDKPIDGLEQSRPSNKDQQMTQNEQPIYTESALVTGPDVRDPRGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLC6</accession>
    <name>A0A9W9WLC6_9EURO</name>
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        <submittedName>
            <fullName evidence="7">Actin-like protein arp5</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">N7539_008896</name>
    </gene>
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        <name type="scientific">Penicillium diatomitis</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785868.1">
        <property type="nucleotide sequence ID" value="XM_056938491.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81628741"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARP5 actin-related protein 5 homolog"/>
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    </dbReference>
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        <property type="entry name" value="Chromatin remodeling complex subunit (Arp5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000025">
        <property type="entry name" value="Chromatin remodeling complex subunit (Arp5)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Actin, Chain A, domain 4"/>
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    </dbReference>
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        <property type="entry name" value="Actin"/>
    </dbReference>
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        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Actin"/>
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    </dbReference>
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        <property type="entry name" value="Actin-like ATPase domain"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="521"/>
            <end position="545"/>
        </location>
    </feature>
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        <location>
            <begin position="308"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="433"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5469278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="753" mass="86652" checksum="2675467AE90B480C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLZ1</accession>
    <name>A0A9W9WLZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="2 12">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_009255</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="10 12">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="2 12"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786227.1">
        <property type="nucleotide sequence ID" value="XM_056938850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLZ1"/>
    <dbReference type="GeneID" id="81629100"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000025">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10 12" id="KW-0274">FAD</keyword>
    <keyword evidence="3 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="14">
        <location>
            <begin position="50"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="13">
        <location>
            <begin position="394"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="189"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="226"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="366"/>
            <end position="369"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="87"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5469637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="513" mass="54469" checksum="1211262E5106ADD7" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WM45</accession>
    <name>A0A9W9WM45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_009271</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786243.1">
        <property type="nucleotide sequence ID" value="XM_056938866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WM45"/>
    <dbReference type="GeneID" id="81629116"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000050">
        <property type="entry name" value="Nuclear protein (Sgd1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="5">
        <location>
            <begin position="636"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="205"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="238"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5469653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="873" mass="98674" checksum="1550AB7803CDA3FF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WM65</accession>
    <name>A0A9W9WM65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB/POZ protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007695</name>
        <name evidence="2" type="ORF">N7539_009360</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
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            <end position="77"/>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5469742.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5475408.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="247" mass="28240" checksum="32A4B5244896DA17" modified="2023-11-08" version="1">MSELKDVLQDLLLRGRFSDMEILCQGITFRVHKAIVCTQSSYFYSAMCDGFKESIDRAINIEDDTPETMERVLSFLYLRDYNEDGHILQYHQPISTLAICDHDSSSSLSENKPEISEPANRVAFNNIEVFIAADKYAILPLKALATLKLSQWADKNWCSPMFNEVVQKVMTSVPQHELSLREVIADIISRHVFDLIQDPEIVRTLDSFGCLGSLVIMKLISNEMVKRPHDNYVLPLGTRISSSRRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9W9WT07_9EURO</name>
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        <recommendedName>
            <fullName evidence="5">HLH DNA binding domain protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">N7539_008031</name>
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    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Nielsen M.R."/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9W9WT09_9EURO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
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    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056935693.1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5474962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5483891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="67" mass="7331" checksum="4EF00DD18A4377FC" modified="2023-11-08" version="1">MYATVVAITATGAQMLSIWPPNGEEPQSEDQAKFWSRVIQISASEKTTQYLACSGVESLQASEEAYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WT19</accession>
    <name>A0A9W9WT19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-patch domain-containing protein</fullName>
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        <name evidence="5" type="ORF">N7539_008043</name>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5474977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786735.1">
        <property type="nucleotide sequence ID" value="XM_056937643.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A9W9WT19"/>
    <dbReference type="GeneID" id="81627893"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Putative G-patch DNA repair protein (Drt111)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RBM17"/>
    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="379"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="454"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="159"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
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        <location>
            <begin position="222"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5474977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="60599" checksum="F8EC4876BD401F43" modified="2023-11-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WT52</accession>
    <name>A0A9W9WT52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_008080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat AIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786772.1">
        <property type="nucleotide sequence ID" value="XM_056937680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WT52"/>
    <dbReference type="GeneID" id="81627930"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000102">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000167">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="531"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="574"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5475014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="610" mass="64634" checksum="0D6E208D6391C1B1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU22</accession>
    <name>A0A9W9WU22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787289.1">
        <property type="nucleotide sequence ID" value="XM_056937424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WU22"/>
    <dbReference type="GeneID" id="81627673"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF3">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="130" mass="14018" checksum="D53E4278E9387F7A" modified="2023-11-08" version="1">MVDQEQPMVSHGRGGQGNIGKDTTEYVDGEIVREGIYGDQGDGAYSAGRGGVGNIGSPRVRPSSKVPHDAEMIPELAVRDSIDENYHTGRGGQGNVHLDNETRKEKEAKKKGVAHEGLADKLKHKLMGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU25</accession>
    <name>A0A9W9WU25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_008168</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786860.1">
        <property type="nucleotide sequence ID" value="XM_056937768.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81628018"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18019">
        <property type="entry name" value="DEXHc_Brr2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000005">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000133">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000368">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000013">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="534"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="757"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="1385"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="197"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
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            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5475102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="2203" mass="248828" checksum="C27E89050D57E996" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUM3</accession>
    <name>A0A9W9WUM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5476999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056936744.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81626993"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844">
        <property type="entry name" value="SER/THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844:SF2">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5476999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="281" mass="32382" checksum="E2E4E115E0674237" modified="2023-11-08" version="1">MLKRFNAIFNKHGTAFQVLSDLHLEVNQQYQTYEVPTCAPNLILAGDIGRLCDYEKYRDFLQYQTDRFQQVFLVLGNHEFYSQSFASALESARAMAQEACFEGRLILLHQTRYDMPDSLVTILGCPLWSHIPEDQKGVVTSTIQDFKQIEGWTAEDHNQSHVSDLTWLSHEIDAIQASNRQKPMDERRVVLVVTHHAPSIQRTSHPQYQYSPWRSAFATDVVARMSELTGVKAWVFGHTHYCTDVKERGVRIIANQRGYKFTSDDSKEPKDGFDSRKVIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUQ0</accession>
    <name>A0A9W9WUQ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787185.1">
        <property type="nucleotide sequence ID" value="XM_056937320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUQ0"/>
    <dbReference type="GeneID" id="81627569"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="43597" checksum="32AF6ADB543DA260" modified="2023-11-08" version="1">MATEDDNFDIDIYGDGGGFNGDEQGDGKHDADDFDIDIGEPDAQPKTNVHNAQQSASTSKPQNQPTNSTPSHEPRASQSGPTAPQSNTDHAMSHEQRPAPDASVAPHGVKRKEYEDGSSDPDATSALMISDLFWWTTDDDIRGWVNKASAEDDLKDLTFSEHKVNGKSKGQVYVEFNAVQAARATKNYLENATDRKYNVQYCSAQFNPFKTLPKDAPMRKEASRGGSFNSGGNQNFGGPAGGNNVHSGGFRGRGGYNNRGMGHMGGYHNRNNFNNMGGYQGGAGPAAGGMMGGFQGNPMGGMQNYGFNNRGGMMNMRGGPGGMRGGRGGGMAAPGMMMPGMNPMGGMGMNPMAGGMNPMMGNMGANMGNNMGGNMGMQGFQGPNPGFNQNFFGGNPGGDGNWNPHGAKRSRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUS7</accession>
    <name>A0A9W9WUS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_007267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787667.1">
        <property type="nucleotide sequence ID" value="XM_056936868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUS7"/>
    <dbReference type="GeneID" id="81627117"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5477123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="92" mass="10529" checksum="53E5B6217D6C32A4" modified="2023-11-08" version="1">MSNPMHGDKRRWMPDQAVDFHQQNMACSGRSRLKYDNKINSTRDHAAESIRSRAKLNVWGCTRPSSPVINTPSVMWLRTVVDRANFDHGTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUU5</accession>
    <name>A0A9W9WUU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-1-tetrahydrofolate synthase, cytoplasmic</fullName>
            <ecNumber evidence="8">1.5.1.5</ecNumber>
            <ecNumber evidence="7">3.5.4.9</ecNumber>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">N7539_007794</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="7"/>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787260.1">
        <property type="nucleotide sequence ID" value="XM_056937395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUU5"/>
    <dbReference type="GeneID" id="81627644"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009257">
        <property type="term" value="P:10-formyltetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001123">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.770:FF:000001">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="17" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="21">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="22">
        <location>
            <begin position="142"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAJ5475507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="938" mass="100282" checksum="B382FE68B5C522EB" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV45</accession>
    <name>A0A9W9WV45_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787853.1">
        <property type="nucleotide sequence ID" value="XM_056937054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV45"/>
    <dbReference type="GeneID" id="81627303"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="644" mass="71823" checksum="9BC1810D5C5BAABE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVB2</accession>
    <name>A0A9W9WVB2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">54S ribosomal protein L12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_007456</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787856.1">
        <property type="nucleotide sequence ID" value="XM_056937057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVB2"/>
    <dbReference type="GeneID" id="81627306"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_bL12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="5">
        <location>
            <begin position="53"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="4">
        <location>
            <begin position="120"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5477312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="187" mass="19885" checksum="12C8CFF5CE4ED4E1" modified="2023-11-08" version="1">MSFPIQTVARSCRQLSGSVRPSSLRIATTYTARTPSYRRWESTEAAAAPVNPKIAQIVDQISTLTLLETADLVSSLKTRLNIPDLPVGGFAMAAGPGGAAAAPAAEEEEAAPAAAEKTLFNLKLESFEAASKAKIIKEVKNMLGLSLVDSKKFVESVPKVLKESVPKEEAEKIMETLKGLGAKVVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVM9</accession>
    <name>A0A9W9WVM9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_007636</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788036.1">
        <property type="nucleotide sequence ID" value="XM_056937237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVM9"/>
    <dbReference type="GeneID" id="81627486"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5477492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="213" mass="25358" checksum="A092C226AC7151AA" modified="2023-11-08" version="1">MYYANREADKMGALKYVEEIQKKKQSDVIRFLLRVRCWELRQLNVIHRASRPSRPDKARRLGYKAKQGYVIYRVRVRRGGRKRPAPKGATYGKPTNQGINQLKYQRALRATAEERVGRRCANLRVLNSYWINQDSTYKYFEVICVDPQHKAIRRDARINWICNPVHKHREARGLTATGKKSRGINKGHRYNNTKAGRRHTWKLQNTQSYWRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1W8</accession>
    <name>A0A9W9X1W8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788369.1">
        <property type="nucleotide sequence ID" value="XM_056936434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1W8"/>
    <dbReference type="GeneID" id="81626683"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5480939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="639" mass="69472" checksum="ADE3700CD7D2AAF0" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X264</accession>
    <name>A0A9W9X264_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TOM core complex subunit Tom6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788504.1">
        <property type="nucleotide sequence ID" value="XM_056936569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X264"/>
    <dbReference type="GeneID" id="81626818"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020266">
        <property type="entry name" value="Tom6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17112">
        <property type="entry name" value="Tom6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5481074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="59" mass="6258" checksum="D6BD44F78CA78C62" modified="2023-11-08" version="1">MAPKRVAVSSSSRPQKSFLSTVYDEATNPENATIVRSLLVFGAGVAFLHSSLGELLLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2C7</accession>
    <name>A0A9W9X2C7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trans-sulfuration enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_007015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788551.1">
        <property type="nucleotide sequence ID" value="XM_056936616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2C7"/>
    <dbReference type="GeneID" id="81626865"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000072">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000066">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF35">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE (AFU_ORTHOLOGUE AFUA_7G01590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5481121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="396" mass="43195" checksum="B75255542A71EEEE" modified="2023-11-08" version="1">MAQSTGTSTRSLHADDVLNVVTDVAPPMHLSTTFRYTANPSALVPWANLDHSSGDPTTHTYSRVSAPSSSRFETILSSLLNGKAVAYSSGLSALHAALTLLNPRRISVGEGYHGCHGVIALFSRMTGLQKLPLDCAPNDLQTGDVILLETPVNPTGIAFDISAFAEKAHSQGAYLIVDSTFAPPGLQDPFPLGADLVMHSGTKYFGGHSDLLCGVLATQREDWAQQLLTDRIFIGSVMGNMESWLGVRSLRTLEIRVQRQSESTSRLVSWLHSALHASNPARGSDEVAIQTVLKDVLHASVQPEVQGDWLKKQMPNGFGPVFSIVMKEEKMARELPSRLHFFQHATSLGGVESLIEWRTMSDASVDRRLLRISVGLENWEDLKTDLGRAFRELADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2H9</accession>
    <name>A0A9W9X2H9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788475.1">
        <property type="nucleotide sequence ID" value="XM_056936540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2H9"/>
    <dbReference type="GeneID" id="81626789"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="653"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="606"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5481045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="728" mass="80059" checksum="5D5E4F35A0F5F802" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2M8</accession>
    <name>A0A9W9X2M8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7614 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5481120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="105" mass="11860" checksum="71D5395D829F011C" modified="2023-11-08" version="1">MVVPIYKKWEASSARIQIVQREKIIQLIAFFSDFQHGTCMNFVLKGTDQIESFTRSGKFGIRIIDAKFALPSKEESAASGFVCLDMPEYPIEHDDIAIAFDKEPG</sequence>
</entry>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789000.1">
        <property type="nucleotide sequence ID" value="XM_056936076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X3G7"/>
    <dbReference type="GeneID" id="81626325"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5483028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="800" mass="89147" checksum="904CF1EEFE04BB60" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X4X6</accession>
    <name>A0A9W9X4X6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5483932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="97" mass="10499" checksum="6A9FF29BE3C50AA5" modified="2023-11-08" version="1">MRDINAYEANSSPSQYHLQSCTPRQEDTAVTAVTAVTAVTARSRKDSDRPATEWDSDPAAGLWNENAIARKFGNTSLAGFPVASSLVEWTRALPSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X597</accession>
    <name>A0A9W9X597_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_006070</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamate + NADP(+) + H2O = 2-oxoglutarate + NH4(+) + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11612"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.4.1.4"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 10">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000007">
        <property type="protein sequence ID" value="KAJ5483870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789140.1">
        <property type="nucleotide sequence ID" value="XM_056935672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X597"/>
    <dbReference type="GeneID" id="81625921"/>
    <dbReference type="Proteomes" id="UP001148312">
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    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004354">
        <property type="term" value="F:glutamate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutamate dehydrogenase"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
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        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
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    </dbReference>
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        <property type="entry name" value="Glu_Leu_Phe_Val_DH"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
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        <property type="entry name" value="PRK09414.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="192"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
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        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="9">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5483870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="462" mass="49807" checksum="9BD04A27734BB9D1" modified="2023-11-08" version="1">MTAQNLPYEPEFEQAYKELASTLENSALFQKKPEYRKALQVVSVPERVLQFRVVWEDDKGQVQINRGFRVQFNSALGPYKGGLRFHPSVNLSILKFLGFEQIFKNALTGLNMGGGKGGSDFDPKGKTDNEIRRFCVAFMTELCKHIGADTDVPAGDIGVTGREIGYMFGQYKKIRNQWEGVLTGKGGSWGGSLIRPEATGYGVVYYTEHMIKYASGGKESFAGKRVAISGSGNVAQYAALKVIELGGSVISLSDSQGALVLAGEEGSFTPEEINTIAEIKVQRKQISELASTEAFASKFKYIPGARPWTNIAGRIDVALPSATQNEVSGEEAKALIDAGCKFIAEGSNMGSTQDAIDVFEAHREANPGAAAIWYAPGKAANAGGVAVSGLEMAQNSSRVSWTAEEVDNRLKGIMEDCFKNGLSTAQEYVTPKEGVLPSLVAGSNIAGFTKVAEAMKDQGDWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5D9</accession>
    <name>A0A9W9X5D9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Stress activated MAP kinase interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_005922</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789396.1">
        <property type="nucleotide sequence ID" value="XM_056935524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5D9"/>
    <dbReference type="GeneID" id="81625773"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000263">
        <property type="entry name" value="Stress activated MAP kinase interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031567">
        <property type="entry name" value="CRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008828">
        <property type="entry name" value="Sin1/Avo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031313">
        <property type="entry name" value="Sin1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056385">
        <property type="entry name" value="UBL_AVO1/Sin1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335:SF1">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16978">
        <property type="entry name" value="CRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16979">
        <property type="entry name" value="SIN1_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23164">
        <property type="entry name" value="UBL_AVO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIM" evidence="3">
        <location>
            <begin position="352"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="AVO1/Sin1 ubiquitin-like" evidence="5">
        <location>
            <begin position="600"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="SIN1-type PH" evidence="4">
        <location>
            <begin position="722"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="677"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="529"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="677"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5484126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="830" mass="90800" checksum="478982B357B48B69" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5L0</accession>
    <name>A0A9W9X5L0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789340.1">
        <property type="nucleotide sequence ID" value="XM_056935468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5L0"/>
    <dbReference type="GeneID" id="81625717"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040903761" evidence="2">
        <location>
            <begin position="23"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5484070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="498" mass="52177" checksum="58075E1798D53F96" modified="2023-11-08" version="1">MVKTTYALTLFAAVSIAAPVQNAPTMDMARGEPMRRDGSGNLLGAGAGGAANDLVSQAFSSLEKQPANKAAEKTPQRTQGTQDAQNQNSNILGNLPVLGSVLGGGSKRSLEGNSKESQSAPQRTEGMQDSNNQNSNILDSLPLIGGVLGGGLKRSVESRSLTSDLSNFPVLGKLFSGNQNDNQNVNKPLGDGNAMPSNYDPSGKKVGKAAAESAMGENGQKARRDLNSDLTEKINALPIIGDLIGNKKKQASGKRDNTPSQYDPVYNLAEDITNKMEPTYNLADTASAAANARRDLNSDLTEKINALPIVGDLIGNKQKPAAKRAEKMEDSQYDPVYGLGEDLTQEMEPTYELADASSAAAGAVRRDLFDLLKTPQEVAKEKPAAAAAAAAQNPKTQLAQDDRKATDDTKPKNDQAKPAQDTKQGDQNPLAGLFKESGLGALMGNSHHGVGILPMKSRRDASIQARGDPIQGATLPDALLSGGVLGKVTKMLAPGGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5Q1</accession>
    <name>A0A9W9X5Q1_9EURO</name>
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        <submittedName>
            <fullName evidence="9">Zinc transporter ZIP9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_005906</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056935508.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81625757"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="119"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5484110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="401" mass="42559" checksum="EFDD6B7CFEA1119E" modified="2023-11-08" version="1">MEGLFTLLALGIVMAVTSFVVGSLPLALTLSASQLRLISSIGMGVLVGTSLIVIIPEGVETLYSANAVSRKTVGARANAVEWSSEGPISKVIAKDDIHASPSASSIPVPFLDIEPQQKSPLARRHESFESSNALRVRKDETSSAKEQHGKEEEKEGSSPHAWIGVALISGFILMYLIDKVPEYASPTKSDRQPYHISLDNLGSGLRRGSSPSRPDGLLETGPSRQQHSHSMATTMGLVIHAAADGIALGASSTDKGLSFIIFFAIMVHKAPASFGLTSILLKQGLSTRTARAHLLVFSLAAPVGALVTFLFAHLLGTAGGDEAASLWRTGMLLLFSGGTFLYVAVHTMQENGHSSGSRELPQNGYTESRDSPKESDKSMRDLVASVLGMILPLFLQVGHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5Q9</accession>
    <name>A0A9W9X5Q9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_005941</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789415.1">
        <property type="nucleotide sequence ID" value="XM_056935543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5Q9"/>
    <dbReference type="GeneID" id="81625792"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="612"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="380"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="657"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="538"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5484145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="812" mass="88135" checksum="074238E0740FCD10" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X632</accession>
    <name>A0A9W9X632_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Protein arg-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">N7539_004822</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 17">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">In the C-terminal section; belongs to the NAGSA dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">In the N-terminal section; belongs to the acetylglutamate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789618.1">
        <property type="nucleotide sequence ID" value="XM_056934424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X632"/>
    <dbReference type="GeneID" id="81624673"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04252">
        <property type="entry name" value="AAK_NAGK-fArgBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23936">
        <property type="entry name" value="AGPR_C_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24149">
        <property type="entry name" value="AGPR_N_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04263">
        <property type="entry name" value="DUF619-NAGK-FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000019">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000029">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000011">
        <property type="entry name" value="N-acetyl-gamma-glutamyl-phosphate reductase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058924">
        <property type="entry name" value="AGPR_dimerisation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041734">
        <property type="entry name" value="NAGK-fArgBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011241">
        <property type="entry name" value="NAGK/NAGSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22698">
        <property type="entry name" value="Semialdhyde_dhC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036440">
        <property type="entry name" value="ARG5-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 17" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="15 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16 17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12 17" id="KW-0521">NADP</keyword>
    <keyword evidence="9 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="20">
        <location>
            <begin position="352"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="544"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR036440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ5484834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="902" mass="98517" checksum="A610D36796B4F2D4" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6E6</accession>
    <name>A0A9W9X6E6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_005850</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789324.1">
        <property type="nucleotide sequence ID" value="XM_056935452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6E6"/>
    <dbReference type="GeneID" id="81625701"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="195"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5484054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="468" mass="50229" checksum="60B23F02868A1DA2" modified="2023-11-08" version="1" fragment="single">EPKQRGTGLQNLGSSTGHSTSTRHSCLPQWRHITMPICIECSYPVSHLYSAYSRADDRSQGKGVRLTQCPRCQRFADKYVEYDFVVIFIDLVLIKPQVYRHLLFNRLGRDDNLFDRSIIRLGVLLLLFDVYLTWARLEKDPSLATTFIARTPIIVQYLFFLTLNAVATVAHHFTVRILASLLVPQSHRYSAPVAMPDVTTTTCPPSGVSDTTTPVPSHPPTPTIRPSPPPGQANNSATQPLISLGLPATKSTPNLHGASISGETASPQDTTPASSTQTQTQPSSISQRPPHQPSLQRASTAPMQNIRPLPPPTAASPTAISTALLVSSCAKLFPILLVIWGADGIHTGRTNPAAPGSMVRKGIGASKAALSSARDTTASPSLLESTLASVEVSLRPYLPTQYLTGLFDLLASLLSLGVVDAHLVLLSNIEALYILLGCGYFRSVVVAVAGQVARWAVQKVILGAVGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6P1</accession>
    <name>A0A9W9X6P1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_005265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790061.1">
        <property type="nucleotide sequence ID" value="XM_056934867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6P1"/>
    <dbReference type="GeneID" id="81625116"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5485277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="65" mass="7397" checksum="0C0F45EA68DE3BB2" modified="2023-11-08" version="1">MREPPGFYRGVSLIVRFLSLLRRPISSFSLLALIISTQSAKSSTRLGNILISFENENILIDFIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6T2</accession>
    <name>A0A9W9X6T2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquinol-cytochrome c chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_005335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790131.1">
        <property type="nucleotide sequence ID" value="XM_056934937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6T2"/>
    <dbReference type="GeneID" id="81625186"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007129">
        <property type="entry name" value="Ubiqinol_cyt_c_chaperone_CPB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="3">
        <location>
            <begin position="181"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5485347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="352" mass="39055" checksum="1C24F250EEBFBC83" modified="2023-11-08" version="1">MTSRANLSTFTPRSTSTSPALMQSATTTTIPSKSPASRSSTAPSARRISSTSRSYAQGGSGSAISRLAKSALSPGSSGETYVAYGMTQKLFQACSSQADYQVPQATQKGVPVPTTEAGEHLGVSDSWWYKEMYQWFPLEALLRLVYRKVTALFPAIIHDPPVLDAELESFTNSMCVFPPPELGLVPTFSTWSQITFLHMYLLTVRLRALPNRESFQTYSRHLIDHFSHNAEHRMDDLHDIGSRSIRNKYLKDLFVQWRGIIAAYDEGLIKGDAVLGAAVWRNLWKAEAVGPDGKELDWSRIALVVAYMRRVTAQLGRMEEADIVMELSGATGQESRIFGFSPLDRKMVEGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X726</accession>
    <name>A0A9W9X726_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Polyketide synthase-nonribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_005531</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790327.1">
        <property type="nucleotide sequence ID" value="XM_056935133.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81625382"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19532">
        <property type="entry name" value="C_PKS-NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="12">
        <location>
            <begin position="10"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="13">
        <location>
            <begin position="950"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="2391"/>
            <end position="2468"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="3557"/>
            <end position="3634"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="9">
        <location>
            <begin position="950"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="9">
        <location>
            <begin position="1097"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2476"/>
            <end position="2516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2537"/>
            <end position="2567"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="9">
        <location>
            <position position="982"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="9">
        <location>
            <position position="1157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5485543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="3989" mass="438020" checksum="5277EBF54D730E08" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X785</accession>
    <name>A0A9W9X785_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_005637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790433.1">
        <property type="nucleotide sequence ID" value="XM_056935239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X785"/>
    <dbReference type="GeneID" id="81625488"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053226">
        <property type="entry name" value="Pyrrolopyrazine_biosynth_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419:SF1">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5485649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="329" mass="37387" checksum="3DD472F2EAA6DC38" modified="2023-11-08" version="1">MAIENKPPLLLLTYPRSASNLLVRILSLPQQPNTVAAESGGYFFYDARDHVRQSKLQERLPAEWTEQEWEAMADKIQSCYDNFKGLIDRAETEGKRAVIKEHAPWLICPRVQASYVHGQEYLDAPFKVKDEASPVGQLMAGIPRNETVLPDAILLRCVPTFLVRHPALAFPSYFRAKMSFSTKKLEDHVVDMTAICTLRWTRNLYDWYTAAWKGQKSPIILDADDIINNREVPRHFCDLVGLDAGKVQFQWDAATPENMPQNPVESRFRSTLLASSGIVAGKTLQGLSIEKEAVKWRAEFGDSVAAKLQQLIQDAMADYEYLWSRRLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCE8</accession>
    <name>A0A9W9XCE8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Sulfite reductase [NADPH] subunit beta</fullName>
            <ecNumber evidence="6">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">N7539_003685</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the reduction of sulfite to sulfide, one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Alpha(2)-beta(2). The alpha component is a flavoprotein, the beta component is a hemoprotein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790828.1">
        <property type="nucleotide sequence ID" value="XM_056933287.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81623536"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000003">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000004">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000085">
        <property type="entry name" value="Sulfite reductase [NADPH] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000051">
        <property type="entry name" value="Sulfite reductase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.480.20:FF:000012">
        <property type="entry name" value="Sulfite reductase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000016">
        <property type="entry name" value="Sulfite reductase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010029">
        <property type="entry name" value="PRK13504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493:SF47">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="20">
        <location>
            <begin position="786"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="222"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00063391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00067595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ5488795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1530" mass="168475" checksum="F055AA3203377BD2" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCG4</accession>
    <name>A0A9W9XCG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790782.1">
        <property type="nucleotide sequence ID" value="XM_056933241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCG4"/>
    <dbReference type="GeneID" id="81623490"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055100">
        <property type="entry name" value="GNAT_LYC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF4">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22998">
        <property type="entry name" value="GNAT_LYC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="394" mass="44913" checksum="F2892801EBB81260" modified="2023-11-08" version="1">MIAANSPHLPDGDSPDLVLVPATPQERIAAIKLNSAAWKGPLDIDAYIAREDHLHNHQLVRDGMTCWILVDGSEPEGDRTILSSCETYPKKALLAYQGQVEEVSTHGIGSVYSRPEFRGKGYAKRMMEELGKKLETWKMEKQPRGKTSFTILFSDIGKKFYAQFGWRPYAAAHMVLPARAMEDTDQVSESNGTSNRGKTRDLLAEDVERTMCHPNIIADLRNELQRASSKSQTAQVAILPDYDHYSWHWAREEFFVQELYPDRSPPLIKGAGDDDAHVYCTWNRNFGDTPENSVLYILRWVYDKPQSAEEEQSLIQAMVDILRRAQHEAKDWGLATVEFWNPDPILQKAVQTLDSDVQVEHREKSSIPSLRWTGDKHGLGQEVEWVLNEKYAWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCH1</accession>
    <name>A0A9W9XCH1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790765.1">
        <property type="nucleotide sequence ID" value="XM_056933224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCH1"/>
    <dbReference type="GeneID" id="81623473"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40644">
        <property type="entry name" value="UPF0653 PROTEIN C607.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40644:SF1">
        <property type="entry name" value="UPF0653 PROTEIN C607.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="317" mass="35937" checksum="987E6CAFD1762217" modified="2023-11-08" version="1">MPHKHKRRDKDDSHFDLPPSVIAKALPVRDQQAKPKPGQKSQHGKKPQPKPQPRTQTNAKPPKAPATSRRKNATELDTPKAFQRLMQYASTGKRLSGLDNGEKKQANKKRKREDSDSKEKTSKKPVDDKAAPPAAKESKDVKQPMPKILPGERLADFAARVDRELPLSAMTKSSSGAPKVKDHKMTKHEKHLRRLQAGWREEDAKIKEREQAEREEREAEMEEQLDILKQWDAEARGGKAKKKGIAPKKKKGSNGADDSGDDDPDPWAKLKKRDKERQANPFEVAQAPPQLTKPREIFKVRGEPWLMLLMFQMPLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDD0</accession>
    <name>A0A9W9XDD0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex II-specific subunit 65 IgD3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791338.1">
        <property type="nucleotide sequence ID" value="XM_056933797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDD0"/>
    <dbReference type="GeneID" id="81624046"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055420">
        <property type="entry name" value="IgD3_Trs65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024662">
        <property type="entry name" value="Trs65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159:SF1">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12735">
        <property type="entry name" value="IgD3_Trs65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex II-specific subunit 65 IgD3" evidence="2">
        <location>
            <begin position="408"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="579" mass="63802" checksum="97F4FE2C6236DB05" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDK1</accession>
    <name>A0A9W9XDK1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_004209</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791352.1">
        <property type="nucleotide sequence ID" value="XM_056933811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDK1"/>
    <dbReference type="GeneID" id="81624060"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic-ring-hydroxylating dioxygenase alpha subunit C-terminal" evidence="8">
        <location>
            <begin position="140"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5489319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="375" mass="43739" checksum="49D0F2E6F17448FE" modified="2023-11-08" version="1">MSFLRNWFGTTTTAPEVQKEQKTPVRALPASWYTSQEMYELERRSIFSRKWLLTTHKHRVPNAGDWVEYDAAGFKFIVSRDDQGQIKAYLHDNSLTPIHVHIDRNDFIWVNLDCSETPEVAWEDDFQGVDEQPRFDYYNFDEYNFDHTWDMEGEFNWKILADNYNECYHCQVAHPDIPTIADLHSYYVKTKDGHIQHYGAQRQDQIDKGFRIATTYFWPNASCNVSPHFFFMQRFTPMSPTKSVMRYEVYRHKDATDEQFELISNMYKRIMSEDKYLCIHTQKNLNAGVFVNGLLHPEMEKGPLHFQSTVREVVTEHFDKEEAAGHQIWPAKVETPKAEIGVEGEIALRTGNTTYADADIMQDSFTGGLAPAIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE16</accession>
    <name>A0A9W9XE16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell wall biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_004401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791544.1">
        <property type="nucleotide sequence ID" value="XM_056934003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XE16"/>
    <dbReference type="GeneID" id="81624252"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="MTH1187/YkoF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5489511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="63" mass="6646" checksum="3712F583E84B4A77" modified="2023-11-08" version="1">MTTTAATADTPDYCVADFSLVPPQIGSSTSSYAHELAGVHRLVRESGLKNQMHPTGTRIGKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEB7</accession>
    <name>A0A9W9XEB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation initiation factor RLI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-binding cassette sub-family E member RLI1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_004198</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the multifactor complex (MFC) involved in translation initiation. Required for the binding of MFC to the 40S ribosome. Required for the processing and nuclear export of the 60S and 40S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791341.1">
        <property type="nucleotide sequence ID" value="XM_056933800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEB7"/>
    <dbReference type="GeneID" id="81624049"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03236">
        <property type="entry name" value="ABC_RNaseL_inhibitor_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000144">
        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000152">
        <property type="entry name" value="ATP-binding cassette, sub-family E, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034348">
        <property type="entry name" value="RLI_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="66"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="323"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00082546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5489308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="600" mass="67536" checksum="8ACCFCFAB5A8E5A4" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XED3</accession>
    <name>A0A9W9XED3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791770.1">
        <property type="nucleotide sequence ID" value="XM_056934229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XED3"/>
    <dbReference type="GeneID" id="81624478"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="631" mass="71047" checksum="60F33FBADBBEA00E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XED4</accession>
    <name>A0A9W9XED4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhamnogalacturonan endolyase</fullName>
            <ecNumber evidence="4">4.2.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_002267</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endotype eliminative cleavage of L-alpha-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronic acid bonds of rhamnogalacturonan I domains in ramified hairy regions of pectin leaving L-rhamnopyranose at the reducing end and 4-deoxy-4,5-unsaturated D-galactopyranosyluronic acid at the non-reducing end.</text>
            <dbReference type="EC" id="4.2.2.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polysaccharide lyase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.23" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791829.1">
        <property type="nucleotide sequence ID" value="XM_056931870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XED4"/>
    <dbReference type="GeneID" id="81622119"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102210">
        <property type="term" value="F:rhamnogalacturonan endolyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10316">
        <property type="entry name" value="RGL4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10320">
        <property type="entry name" value="RGL4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051850">
        <property type="entry name" value="Polysacch_Lyase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029411">
        <property type="entry name" value="RG-lyase_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32018:SF9">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32018">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14683">
        <property type="entry name" value="CBM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040997855" description="rhamnogalacturonan endolyase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="12">
        <location>
            <begin position="343"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="11">
        <location>
            <begin position="432"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5490700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="645" mass="71518" checksum="CC7922D1F7E51C63" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEN5</accession>
    <name>A0A9W9XEN5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_002293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791855.1">
        <property type="nucleotide sequence ID" value="XM_056931896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEN5"/>
    <dbReference type="GeneID" id="81622145"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="67"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5490726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="306" mass="33457" checksum="1A682864E1214A5A" modified="2023-11-08" version="1">MALTQPSSPYVFTTAIQPPPGPSARLVIPSEFLQRTETPDPSLQSASAITNSSSNENPPVFNDAMKVRARVFIHEQHCSVEGEIDEDDPRSWQWVIYATEAPSTTHSPSPLASGTPQPVAVIRLVPPPHLPHEALFHDDAVQDFSNDHGLSSQPLPSYDWTHEPCIKITRVAVLPEFRGLGLGRKLLDVALDWASTHAEEIDNAARQLAIRVGVGSGAGRESQHESTGSDSQSPAASMGHRGAEQRRDEKVSTAPWRGLVLVHAQVDVEAMYRGMGFTQDKALGMWDEEGIQHVGMFRRVDVQSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEQ4</accession>
    <name>A0A9W9XEQ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002472</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792034.1">
        <property type="nucleotide sequence ID" value="XM_056932075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEQ4"/>
    <dbReference type="GeneID" id="81622324"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019190">
        <property type="entry name" value="EXOV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464:SF4">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09810">
        <property type="entry name" value="Exo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5490905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="647" mass="72632" checksum="FEBBB2A90A7CBA27" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF49</accession>
    <name>A0A9W9XF49_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">N7539_002355</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791917.1">
        <property type="nucleotide sequence ID" value="XM_056931958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF49"/>
    <dbReference type="GeneID" id="81622207"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000230">
        <property type="entry name" value="Putative dihydrouridine synthase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="19">
        <location>
            <begin position="38"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="332"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="486"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ5490788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="577" mass="63699" checksum="43F4510E70C0D51D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF86</accession>
    <name>A0A9W9XF86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein mago nashi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_002727</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792289.1">
        <property type="nucleotide sequence ID" value="XM_056932330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF86"/>
    <dbReference type="GeneID" id="81622579"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5491160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="250" mass="28524" checksum="D1AB11CA427A0797" modified="2023-11-08" version="1">MGVFVGDAQMGGGGKRKWEHQPVPLDPQVRSRLSVGIRLELVLDGSCENHGIAQLEMSTNDTFYLRYYSGHSGRFGHEFLEFDFRTIADGTSAAVRYANNSNYRNDSLIRKEMCVSSAIIEEIKHIIKQSEVLKEDDSKWPKKNKDGRQELEIRLGGEHISFETAKIGSLVDVAESDDPEGLRVFYYLVQDLKALVFSLISLHFKQENYGGEMRRRLRIQVSMPALTEMLMHYVRAVYMEPIVMEKALVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFL5</accession>
    <name>A0A9W9XFL5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Xanthine/uracil permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_002803</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792365.1">
        <property type="nucleotide sequence ID" value="XM_056932406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFL5"/>
    <dbReference type="GeneID" id="81622655"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF1">
        <property type="entry name" value="XANTHINE_URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5491236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="579" mass="62620" checksum="D87D799FE590FFC1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFT4</accession>
    <name>A0A9W9XFT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792087.1">
        <property type="nucleotide sequence ID" value="XM_056932128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFT4"/>
    <dbReference type="GeneID" id="81622377"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5490958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="186" mass="20623" checksum="C119B4DFFC426B1A" modified="2023-11-08" version="1">MYRSGSYNMMCPDEDDTLSQCGQSQMLWQEQKPPESWQQASQSQLCDVNQPPHEQQQVSQSQLCDVYQPPHEQQQVSQSQLCDVYQPLHGQQPEPLYGQQQLAQLASPLDCLNAHTSTPSGYGYAAPVFVNPHDLMHPHHASFDESQLSTPNCGLSASHDTTGLFLPGPASSSLSQQTTQERTPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG32</accession>
    <name>A0A9W9XG32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_002850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792412.1">
        <property type="nucleotide sequence ID" value="XM_056932453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG32"/>
    <dbReference type="GeneID" id="81622702"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF25">
        <property type="entry name" value="MAP KINASE KINASE PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="256"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="145"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="533"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="548"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5491283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="616" mass="65064" checksum="54FC06EE213B2F7B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG89</accession>
    <name>A0A9W9XG89_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">N7539_003211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAJ5491644.1"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="149" mass="15086" checksum="41742EB3968A584C" modified="2023-11-08" version="1">MHFTSAFISAVTLASVCMGAAVDKRKSWLFSCGCDGQGDANANDCRDAIAQIDVNANVMDPMNAISVVHTGPLSSASIMYQSGNCALAIGNTQNINGPGGVGGGVTGTTISGADFKDLMTQMMGCEDTANGLINACASVGAGNAMIFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGS1</accession>
    <name>A0A9W9XGS1_9EURO</name>
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        <recommendedName>
            <fullName evidence="6">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">N7539_001493</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056931096.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81621345"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
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        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="HTH_MYB"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="213"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
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            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="69"/>
        </location>
    </feature>
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            <end position="122"/>
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        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5492747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39621" checksum="B2F6C775AE3E5198" modified="2023-11-08" version="1">MSVSLADQYRGFAIHTSHEAKPADQSFASYDARTKLNGLPFQPDNAQSIYDHSHHGPLLPHPASQNNAYQDTQTPYMHAHQMPRPSFHYGYEYSPFRSTDKRKRSDSDDEGDGRRQLDHPFATRGSLLSLSIDGTSITDQSESTLFPGHEDISTSLPPTTHAYQPAFSLPVPQQHHHHRLPAQLLNAHDSLVTVSGGPPSVVGQPGMPEPAPRPRGPKLKFTPEEDALLVDLKEEKNLTWKQIADFFPGRTSGTLQVRYCTKLKAKDVVWTDEMLARLQRALSDYEHDKWRIVAAKVGNGFTPAACRERADHLPQYGHEHGHGREILQDREMYSSHQLSDVDTRGSIPRECAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGU0</accession>
    <name>A0A9W9XGU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-binding protein 8A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_001467</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793101.1">
        <property type="nucleotide sequence ID" value="XM_056931070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGU0"/>
    <dbReference type="GeneID" id="81621319"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="41"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="146"/>
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        </source>
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        </source>
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        </source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5492721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="159" mass="17559" checksum="96C5B95E177EC77E" modified="2023-11-08" version="1">MSSEMEVDPPVAQDDSIAEPDRGVEPRTQTGAVAVRSIEGWILMVTNIHEEASEEDITDLFAEHGEIKNFTLSLDRRTGYVKGYALIEYSTLPEAAEAIKELNGSKLLEQTITVDYAFVRPPPSGKNNKNQNQKSIRGAASRGRSRSPERSRSPVGDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        </source>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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            </authorList>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5492689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="81621287"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5492689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="29336" checksum="58BFCCEC757BDE3C" modified="2023-11-08" version="1">MVLEYHSFMHSVVQFLVGKDRKRFLIHTELSSSIPSEILRPPIVEEIDEVVFGRFCEFVYSGDYSVPSPIYDGLGNQAPTEPVRQWDPARLTWNFFHPENLPIVCADLRERLGQVNPKYRANDESTTNPKDSYADIFLCHAEMYRFASRTGWTALYHLTLYHLLQLLANFALCEERTRDIVTLFKFVFEEIDSEFEGIGDINGFEGRGNIKNLLGDYALWNLEILMRDADFQLVLDKMPSLKKGFFRWMWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH02</accession>
    <name>A0A9W9XH02_9EURO</name>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5491452.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="568" mass="62976" checksum="30369B0E5465F9AB" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH09</accession>
    <name>A0A9W9XH09_9EURO</name>
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            <fullName evidence="6">Fungal specific transcription factor</fullName>
        </submittedName>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAJ5492703.1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
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    </dbReference>
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        <location>
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            <end position="45"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5492703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="695" mass="76414" checksum="5D23C84B3C54FD81" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH15</accession>
    <name>A0A9W9XH15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">N7539_001572</name>
    </gene>
    <organism evidence="8 9">
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        </lineage>
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    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
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                <person name="Sorensen T."/>
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        </source>
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        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793014.1">
        <property type="nucleotide sequence ID" value="XM_056930983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHU4"/>
    <dbReference type="GeneID" id="81621232"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03078">
        <property type="entry name" value="GST_N_Metaxin1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="8">
        <location>
            <begin position="21"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="9">
        <location>
            <begin position="218"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5492634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="47837" checksum="0BA9133D2D180967" modified="2023-11-08" version="1">MVLQLHVWGPAFNLPSIDAQCLAAIAYCSLTLPKGSWELVATSDPSVSPTGELPALQDDSTWVSRFRNIVDYLRQYSNGEWDLDGLLEGTARADTIAFSSFIESRGQTLIDLSLYVSSQNYYGNTSPAYGSLLQWPNQWILPPRLHSAAKARTEHLGLSSLDIQAMEEQRQREHSAAVAAGRVPKNLIPRPQDTVSKLLGRTAQHNHFRLEALTGEFFEPLEAMIGDKSYFLASSENDSPSSLDCIALGYLSLALVPELTFPWLRDAMRTKSPHLTAYTERMRRLCFGEQPVEIAHAFSPETAPSSLLPWRAPSRISAVAVSNTLLDTLAESLPLVRTLRSHNKLKEGAQSADAGLSDMEKKIVSQAADAGKNDLYASVATVVGGLAALVGYMFYIGMIRPTGSGDEEFVEEVEGEEEASVFDAGSATDFLGAGFSGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHU8</accession>
    <name>A0A9W9XHU8_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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    <reference evidence="2" key="1">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
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    <dbReference type="GeneID" id="81621767"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="228" mass="26029" checksum="18442B72E58269F9" modified="2023-11-08" version="1">MANDDGAHYHQSWKDRLSAFEQQFDAQSSSFIAQLAAQNENLAAQDAIIAELQARIAEQESKIRQLMKCRKMYFNVRERCWLGFLRDSCVGEGEKHKNRIRLLNSAFVHGGDVTSDARMLCERRPAEENHAFESLYGLQPQEILGLQEAGGRKVLLLLNFVGDTRLQAKWIFNQADDESLREIVRLVGENRLEEAGDLAEAFPVEQKIEITRHALPSRNWGLGQMPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHZ2</accession>
    <name>A0A9W9XHZ2_9EURO</name>
    <protein>
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        </recommendedName>
    </protein>
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    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
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            <strain evidence="1">IBT 30728</strain>
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    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAPWDQ010000002">
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    </dbReference>
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        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF2">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY SUPERFAMILY (AFU_ORTHOLOGUE AFUA_3G13450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KAJ5492875.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="27086" checksum="14E3DA280D14B8A2" modified="2023-11-08" version="1">MVNNILIVGATRGLGASLATFYARDPANQVFGTARSPESPSTPNITWLPGIDVSESDVGQKLVSQIPASTHLSSVILTAGYFGSESFDSPDWEKEVKMYTTSAISPVFVVHHLVKAGLLRKGSKVMIVSSESGSITLRHEKEGGGNYGHHASKAASNMVGKLLSLDLKPQGIAVGLVHPGFMRTEMTKSVGFDKFWDDGGAVTPDEAAQSLASFIETFDISKTGEYWAPRGPRDIGTAEAVLGENLPTPLQLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIE9</accession>
    <name>A0A9W9XIE9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_001861</name>
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    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793495.1">
        <property type="nucleotide sequence ID" value="XM_056931464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIE9"/>
    <dbReference type="GeneID" id="81621713"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5493115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="94" mass="10545" checksum="E65CEE2A97E42A00" modified="2023-11-08" version="1">MTENPFNHELSEESTERLSEGQIPLVTACQEDQWPMDADNLIVGYVVSSRSPQLTSGMSVCKSEHLIIERRAIWVETALRGQSVDPTFTSCKMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM44</accession>
    <name>A0A9W9XM44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794431.1">
        <property type="nucleotide sequence ID" value="XM_056930138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XM44"/>
    <dbReference type="GeneID" id="81620387"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF19">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G01480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="52"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="534" mass="58629" checksum="83EE825F6653DD4D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM97</accession>
    <name>A0A9W9XM97_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794649.1">
        <property type="nucleotide sequence ID" value="XM_056930356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XM97"/>
    <dbReference type="GeneID" id="81620605"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42088">
        <property type="entry name" value="YALI0F10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42088:SF1">
        <property type="entry name" value="YALI0F10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="708" mass="77358" checksum="EE376E827B3C9E75" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMG2</accession>
    <name>A0A9W9XMG2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">N7539_000838</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">MAP4K component of the MAPK pathway required for the mating pheromone response and the regulation of cell polarity and cell cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794735.1">
        <property type="nucleotide sequence ID" value="XM_056930442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMG2"/>
    <dbReference type="GeneID" id="81620691"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008349">
        <property type="term" value="F:MAP kinase kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000385">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000007">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="19">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="577"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="334"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="495"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="499"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ5495722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="858" mass="94323" checksum="FA5D313EFEE19094" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMS4</accession>
    <name>A0A9W9XMS4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794821.1">
        <property type="nucleotide sequence ID" value="XM_056930528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMS4"/>
    <dbReference type="GeneID" id="81620777"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="562" mass="61455" checksum="52AB0168A3F6830A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMW1</accession>
    <name>A0A9W9XMW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carbamoyl phosphate synthase arginine-specific small chain</fullName>
            <ecNumber evidence="4">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Arginine-specific carbamoyl phosphate synthetase, glutamine chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">N7539_000541</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Small subunit of the arginine-specific carbamoyl phosphate synthase (CPSase). CPSase catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, carbonate, and phosphate donated by ATP, the first step of the arginine biosynthetic pathway. The small subunit (glutamine amidotransferase) binds and cleaves glutamine to supply the large subunit with the substrate ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794438.1">
        <property type="nucleotide sequence ID" value="XM_056930145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMW1"/>
    <dbReference type="GeneID" id="81620394"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000016">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000003">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF7">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthase small subunit N-terminal" evidence="20">
        <location>
            <begin position="36"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ5495425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="449" mass="48959" checksum="F5ED412A3D4D2163" modified="2023-11-08" version="1">MFMNIFKSMPARAQAFASVKPQARFMATVRQRAPLEPATFTIRDGPMFTGKSFGARSNISGEAVFTTSLVGYPESLTDPSYRGQILVFTQPLIGNYGVPSAEKDPNGLLKYFESPHLQAAGVVVADVAEQYSHWTAVESLGEWCAREGVPAISGVDTRAIVTYLREQGSSLAKITVGEEYDANEDEAFTDPEQIHLVRQVSTKQPFHISAADPHSHVAVIDCGVKENILRSLVNRGSSVTVFPFDYPIHKVAHHFDGVFISNGPGDPTHCQDTVFNLQRLMETSQVPIFGICLGHQLLALAAGARTIKLKYGNRAHNIPALDLSTGRCHITSQNHGYAVDASTLPSEWKPYFVNLNDQSNEGMIHKSRPIFSTQFHPEAKGGPLDSSYLFDIYLESVQKYKKSQAGLYPQRDSRPSPLLVDLLGNERVGVQPTVGMQNIAAAAAAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJF4</accession>
    <name>A0A9X0BJF4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COQ4</name>
        <name evidence="9" type="ORF">N7539_009154</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:81179"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="4.1.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJF4"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120539">
        <property type="term" value="F:4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="1 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00081568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5469536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="285" mass="32561" checksum="253295230CC7243C" modified="2023-11-08" version="1">MSALGSRSSQGLRKLCYSSSSNMTSVIRPFSVLNRPKPNYPGHVPLTTIERGALALGSAFGSLINPRRADLIAALGEATATPYFIYRLRDAMLSNPTGRRILRDRPRITSETLQMSQLRALPENSVGRAYATWLDREGVSPDTRDNVQYIDDEECAYVMQRYRECHDFYHAVTGLPIFVEGELALKALEFLNTLLPMTGLSLFAFIRMKPAEKERFLTLHLPWAIRSGLKSEELINVYWEEVLEKDVDELRAELNIEQPPDLREIRKMMRQQQKREKERLAQGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJJ8</accession>
    <name>A0A9X0BJJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Exodeoxyribonuclease 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_009289</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786261.1">
        <property type="nucleotide sequence ID" value="XM_056938884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJJ8"/>
    <dbReference type="GeneID" id="81629134"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="14">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="16">
        <location>
            <begin position="138"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="445"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="521"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="521"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5469671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="737" mass="81883" checksum="32DB5B12DB7E85FE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJP9</accession>
    <name>A0A9X0BJP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_009065</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786037.1">
        <property type="nucleotide sequence ID" value="XM_056938660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJP9"/>
    <dbReference type="GeneID" id="81628910"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000092">
        <property type="entry name" value="Mitochondrial tricarboxylate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000064">
        <property type="entry name" value="Mitochondrial tricarboxylate transporter (Ctp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="12"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="102"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="199"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5469447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="296" mass="32019" checksum="67F05F239B25A8DD" modified="2023-11-08" version="1">MAAASRDPTAKPSALRSIIAGSTAGAVEIAITYPAEFAKTRTQLNRRLAEGQKLPWPPFGKQWYAGCTTLIIGNSLKAGIRFVAFDAIKAALQDENGKISGPRTVVAGFGAGVTESLLAVTPFESIKTQLIDDRKAAKPRMNGFLHGSKIIFQERGIRGFFQGFVPTTARQAANSATRFTSYTTIKQLAEGYVAPGEKLGTLATFGIGGLAGIITVYVTQPLDTVKTRMQSLEASKNYKNSFVCAARIFKDEGVLTFWSGAMPRLARLILSGGIVFTMYEKSMELMDLADPERKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BLU5</accession>
    <name>A0A9X0BLU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_008538</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786515.1">
        <property type="nucleotide sequence ID" value="XM_056938133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BLU5"/>
    <dbReference type="GeneID" id="81628383"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06140">
        <property type="entry name" value="Ifi-6-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5471969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="155" mass="15058" checksum="144EBCFA795E3F79" modified="2023-11-08" version="1">MPFRTLSPEDVMAGGTRIMRAGLEGGKIVVAYGKPTLEKSANLAVQAANWSAENPILAACAVVGTTGATILAAPSLATAPVLSSLGFTMNGIQAGSAAATAHSWIGNIVAGSAMAIGQSAGAGGNGLVIVNGAAQLGGAVMTLGSAGIAWIKAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BLX1</accession>
    <name>A0A9X0BLX1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008572</name>
        <name evidence="2" type="ORF">N7539_008791</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5471848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5472003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="171" mass="18527" checksum="0105B4DA5F917EE7" modified="2023-11-08" version="1">MKIIYEILQVRKMEECLSAGIGHLSDAKIDVYVQNLGPSHKSDGDEDGESAGVPAIIEVLERVEDERLNFEGGHDRAFNATPPHHADSISQPVLRTPVTTEISNSHDVSVFDYASHNPSLTATPDQKRTTVGHYDAWSTPTSGQNIFSPVDHSAPPSGQGLLPPSMFPTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSJ3</accession>
    <name>A0A9X0BSJ3_9EURO</name>
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        <submittedName>
            <fullName evidence="4">Transcriptional activator somA</fullName>
        </submittedName>
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        <name evidence="4" type="ORF">N7539_006922</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481028.1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="LisH"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF08513">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="422"/>
            <end position="709"/>
        </location>
    </feature>
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            <end position="86"/>
        </location>
    </feature>
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            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
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            <end position="258"/>
        </location>
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        <location>
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            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
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            <end position="514"/>
        </location>
    </feature>
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        <location>
            <begin position="584"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="598"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="635"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="652"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="698"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5481028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="767" mass="82440" checksum="1B11BDA132CF7510" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSU1</accession>
    <name>A0A9X0BSU1_9EURO</name>
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        <submittedName>
            <fullName evidence="10">MFS transporter asaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_006394</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056935996.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF224">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="183"/>
            <end position="203"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
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            <end position="472"/>
        </location>
    </feature>
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            <begin position="91"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="64"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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            <dbReference type="ARBA" id="ARBA00006727"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
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            <dbReference type="EMBL" id="KAJ5482948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="481" mass="52006" checksum="67D4F301C72E6A07" modified="2023-11-08" version="1">MNDFHQDPVGAPSIADSTTTRALSEHSTPSIANQTHHDMEKGKPTTQPVESQHVPEKDEKASEKAAAGDPALAAAPGPGPPPDGGAEAWMSVLGAFFGLFVSFGWINCIGIFQTYYETHQLRDLSTSTVTWITSLETFIMFFAGPVFGTIFDSYGPRAILLGGTFFHVFGLMMASLSTEYYQFILAQGICSPLGASAVFTASVNSVSTWFAKRRAFALGITASGSSLGGVIFPIMVSNLIPKVGFPWAMRICAFLILGMLVISNVTLRSRIKHTKKPFDIMNFVHPLKDKKFMITVAACFCFFWGMFLPFTFVITQAQRYGMSEHLSVYLIPILNAASVFGRTIPGYLADRVGRYNIMIFFSYLSAILVLALWLPSRSNVPAIIFSALYGFSSGAFVSIVPALIAQISDLREVGVRNGTCFAIISFAALTGTPIGGALVPDVLTGSYTRLQVFCGVVMMVGSSLFVVARVVVGGCNLRKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSU6</accession>
    <name>A0A9X0BSU6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_006890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788426.1">
        <property type="nucleotide sequence ID" value="XM_056936491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSU6"/>
    <dbReference type="GeneID" id="81626740"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5480996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="75" mass="8723" checksum="6A643AFEFC90F945" modified="2023-11-08" version="1">MIIPVRCFSCGKVVGDLWERYLQLLDQGVGDGDAMDQLGCRRYCCRRMVMTHVDLIEKLLRYNTAERERANALEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BTY4</accession>
    <name>A0A9X0BTY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_005944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789418.1">
        <property type="nucleotide sequence ID" value="XM_056935546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BTY4"/>
    <dbReference type="GeneID" id="81625795"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5484148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="145" mass="15868" checksum="96D66BAA49DBF5FB" modified="2023-11-08" version="1">MSVSLLRLRARASTHVNRLATRSLSTSAVLRQTKDNGRPTFGFKDAPAPPRLPKEEQDIFEELQRRSTGAFSTPQVNQSPQSDSQPTINAKGNGEELHPDVPKGLKPEFEGEKNPKTGEVGGPKNEPLRWGAGGDWSYGGRVTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUT9</accession>
    <name>A0A9X0BUT9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_005551</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790347.1">
        <property type="nucleotide sequence ID" value="XM_056935153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUT9"/>
    <dbReference type="GeneID" id="81625402"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF16">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040761421" description="Heme haloperoxidase family profile domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="73"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5485563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="448" mass="49146" checksum="D61E35EAD2F2BFDC" modified="2023-11-08" version="1">MHLHYGLRWLCALPLIVHASAFPGAASNHHDAQLHQDLHKRCPYANHGAPEKIMQHEKRFLVDSMKSPVEVTGVHAFQPPNFEKGDQRGPCPGLNALANHGYIPRNGVVSFAHVIQAINQVYGMGIDLATVLAIMGTVWTGDPLSLDPRFSIGGRSTGVNNLLDNLGGLLAIKGEPQGLIGSHNFIEADSSNTRDDIYVTGNNYVMNMDKFMSWYNMSTDGTFDMDLMALRAKNRFEETIKSNPNFYYGPVTGLIARNAGYIFPGRLFRNHSVDNPEGVLTKYALRNFYAVYGEGSNLTYKEGWEQIPSNWYKTPVDYGLVQLNLDIIDFLLKYPELGSVGGNTGKVNSFAGVDLADLTGGLFNATNLLEGNSLLCFAFEVLKFASPNALSSLYSTLAQPLAFLGNILATPLLDITCPAMKDLQIGGKPFWQAIQDDFPGAKMSGRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUZ4</accession>
    <name>A0A9X0BUZ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 11">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="4 11">4.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_005344</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>L-homocysteine + L-serine = L,L-cystathionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4 11"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790140.1">
        <property type="nucleotide sequence ID" value="XM_056934946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUZ4"/>
    <dbReference type="GeneID" id="81625195"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04608">
        <property type="entry name" value="CBS_pair_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046353">
        <property type="entry name" value="CBS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005857">
        <property type="entry name" value="Cysta_beta_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01137">
        <property type="entry name" value="cysta_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 10 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="365"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5485356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="518" mass="56008" checksum="239AD2BBF8F0A9BD" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXC5</accession>
    <name>A0A9X0BXC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790653.1">
        <property type="nucleotide sequence ID" value="XM_056933112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXC5"/>
    <dbReference type="GeneID" id="81623361"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038212">
        <property type="entry name" value="TF_EnY2_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="183" mass="19807" checksum="7610CB459E38ED71" modified="2023-11-08" version="1">MPSSTPTGGASATPDALESDLLTKLSATSALEDLQETLLVSLHRAGWTEKITSLATELLRAGRCQTFDDVLEAVVASAEGRTHPALGSKHVEKNGGPTSNGTKEGRTNGTRKDKDKDKDKDKNSTHSDSNKSSAPYDPFKYIEEVDVRIPETVVDEGVRGLKDILREMVDLEDENTPNGEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXE7</accession>
    <name>A0A9X0BXE7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_003616</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790759.1">
        <property type="nucleotide sequence ID" value="XM_056933218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXE7"/>
    <dbReference type="GeneID" id="81623467"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.690:FF:000003">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="126"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="168"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="337"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5488726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="553" mass="60285" checksum="58A373CEB56DE417" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXH1</accession>
    <name>A0A9X0BXH1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790788.1">
        <property type="nucleotide sequence ID" value="XM_056933247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXH1"/>
    <dbReference type="GeneID" id="81623496"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5488755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="38864" checksum="4138B3E295047B00" modified="2023-11-08" version="1">MSQPNPNESIQIDTSDDDSLVDTKTLIDSNLSFASSVRDYCYENGRRYHAYRHGQYPFPNDEEEQARLALMHHLFKMLSGGDLFRAPFTRNTLTQSPQIPSRILDIGTGTAEWATEMAEDFPTTTILGTDLSPIQPAWAPPNCRFFIDDAESDWTFSPSEAFDYIHVRSLGGGIADWPRLLRQAYTHLKPGGWFEAQEFETFVLSDDGTHARATRVLNWQDQLNHASNKFGKPMNVAPRLSGWLEDAGFVNVADDIYKCPVGGWAKNRRLKEIGRVGKVTILEVVEPYTLALFTRVLGFSYQDALEYMEKVRAELMSNKFHLYVLFHFVYGQKPLDAHNPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXH6</accession>
    <name>A0A9X0BXH6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-activating enzyme E1 1</fullName>
            <ecNumber evidence="4">6.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_003660</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.45" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790803.1">
        <property type="nucleotide sequence ID" value="XM_056933262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXH6"/>
    <dbReference type="GeneID" id="81623511"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01491">
        <property type="entry name" value="Ube1_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12550:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000015">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.60:FF:000002">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032420">
        <property type="entry name" value="E1_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032418">
        <property type="entry name" value="E1_FCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16191">
        <property type="entry name" value="E1_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16190">
        <property type="entry name" value="E1_FCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="13">
        <location>
            <begin position="909"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="785"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5488770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1043" mass="115664" checksum="DFB7840114E582A8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYD0</accession>
    <name>A0A9X0BYD0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_004309</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791452.1">
        <property type="nucleotide sequence ID" value="XM_056933911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYD0"/>
    <dbReference type="GeneID" id="81624160"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000024">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="77"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5489419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="274" mass="29960" checksum="24CEFEFEF36B81EC" modified="2023-11-08" version="1">MGHHLGLRAAISSRLPREASALVIARAWYRRLPARLPGSTRSQSLCSRVQPLSVRSILAVLVKTHTHHLSMTARLVLVIGDLFIPDRAPDLPAKFRKLLTPGKIGQILCLGNLTDRDTYDFLRQVAPDLQMVKGDYDVDSPNLPLSKVVNHGGLRIGVTHGHTIIPPGDADALLIAARQMDVDILLWGGTHRFEAFEMEGRFFVNPGSATGAMSSGYWPDGEEPTPSFCLMDIQGDVLVLYVYQLKTDANGVENVSVEKVSYRKNHAPAPAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYM7</accession>
    <name>A0A9X0BYM7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial outer membrane protein (Sam35)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_002423</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791985.1">
        <property type="nucleotide sequence ID" value="XM_056932026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYM7"/>
    <dbReference type="GeneID" id="81622275"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03193">
        <property type="entry name" value="GST_C_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03078">
        <property type="entry name" value="GST_N_Metaxin1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021211">
        <property type="entry name" value="SAM35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF44">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN (SAM35), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10806">
        <property type="entry name" value="SAM35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="3">
        <location>
            <begin position="73"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="2">
        <location>
            <begin position="220"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5490856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32779" checksum="97D8A058D9EE210E" modified="2023-11-08" version="1">MPTPTSDGSQTSSGPASFLRIPPPLKRLFDRFPLTTYPANDLPHRVPSKRADNQLFVFSDAAGARRGRPSFNPQCLKWQAYLKFVGVDFEITPSNNHASPTGALPFLLPAFPTEAAVTIPSHKLQKWAIEQVHCEEEQQLDLRFDVYASLLDHRIRNAWLYTLYLDDANFKSVAQRLYVNPSTTSSLVRASLAFQLQQAARDELLKTTSYIDVAAIEGDAQNAFEALSTLLAENEHFFGRPNPGLFDAAVFAYTHLILDEGLGWKHNRLAQMLRQHTNLVQHRERLLKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZG8</accession>
    <name>A0A9X0BZG8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792633.1">
        <property type="nucleotide sequence ID" value="XM_056932674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZG8"/>
    <dbReference type="GeneID" id="81622923"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="324" mass="36937" checksum="00BFFB7D52300E17" modified="2023-11-08" version="1">MLLPHGARRTLGQILQPTMDDEDEETSDTEGSESEDQESRPDAWDVLQVRALLQWRLGMPVEIIDQIIDTAEYWPSTTVKMTIPQDRSHRHIRKDRDQVLLKTVPLCFDRKVGLCGNLPPSPVTSTRDALTNHWIFDCCLEKQLEDAPDAPHPLPSRSYVHPCRKIVFHISSHDQGPGRCHPDMYEHSWTWFDVEVIRAAHTKKMYANGEEQELLPHESGDVVTPRTIEDPLLLPGPGKLQNNGARVAERQDVEIVWHYQDNIPADSPEALEMEKTKGRGRATLDGQFVRDLQVGDSIAIWARARFPGWSNHVYYASATVFWAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZK2</accession>
    <name>A0A9X0BZK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-protein ligase Sel1/Ubx2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002829</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792391.1">
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
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</entry>
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</entry>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5495037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="115" mass="12837" checksum="93199EFC0CBDC439" modified="2023-11-08" version="1">MLAETPGAVAGWLISILRVSRCQLCRKALNTNQASDIYHATSVSCTTRHRFDSDGRLAGTQDHQKRSDRAHPPFAKLSTAWTRCTLWPTVTRPAMRNGPKADFSGWLNEVKVRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794335.1">
        <property type="nucleotide sequence ID" value="XM_056930042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C284"/>
    <dbReference type="GeneID" id="81620291"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21442">
        <property type="entry name" value="SNARE_NTD_STX6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000012">
        <property type="entry name" value="SNARE domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000006">
        <property type="entry name" value="Syntaxin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="154"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5495322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="230" mass="26107" checksum="4DE6884C2E0CAA67" modified="2023-11-08" version="1">MDTTDPFLQVQADVLETLQTSRPLFSSYLRIRSLAKSPQNPELHQSRTELETTLTELTADLDDLVESVRAIEQDPYRFGLELEEVQRRRKLVDDVGREIEQMRTELARAVSAAPAPADLPNPTEFDAALEAEEDGARGPRGDDYYAALEQQRQVELMHEQDEQLDGVFRTVGNLRQQANDMGRELEEQGAILEEVDSLADRVGGKLNNGMKRIRHIVRKNEGKWYPSCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2E7</accession>
    <name>A0A9X0C2E7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_000186</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794083.1">
        <property type="nucleotide sequence ID" value="XM_056929790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2E7"/>
    <dbReference type="GeneID" id="81620039"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="233"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5495070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="476" mass="52805" checksum="B998FC856434DE41" modified="2023-11-08" version="1">MGGGPGGDGRDDKDKKKDKPKYEPPPPPTTRIGRKKRKAGGPSAASKLPDIYPTSRCKLRYLRMQRVHDHLLLEEEYVENMERLRKAKAQAAQGSARPEDPELSDRNADERSRVDDMRGSPMGVGNLEELIDDDHAIVSSATGPEYYVSIMSFVDKDLLEPGASILLHHKSVSVVGVLTEESDPLVSVMKLDKAPTESYADIGGLESQIQEVRESVELPLLHPELYEEMGIKPPKGVILYGAPGTGKTLLAKAVANQTSATFLRIVGSELIQKYLGDGPRLVRQIFTVAAEHAPSIVFIDEIDAIGTKRYDSTSGGEREIQRTMLELLNQLDGFDDRGDVKVIMATNKIESLDPALIRPGRIDRKILFENPDRSSSLLKQNISLRICANTILENTKKKIFTLHTSKMSLGDDVDLDEFINQKDDLSGADIRAICTEAGLMALRERRMRVQMDDFRSARERIMKTKQDGGPVEGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2L2</accession>
    <name>A0A9X0C2L2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794202.1">
        <property type="nucleotide sequence ID" value="XM_056929909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2L2"/>
    <dbReference type="GeneID" id="81620158"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="443" mass="49952" checksum="61BA9633E7587B54" modified="2023-11-08" version="1">MLTELVTYGDLYSFLRKNGDRLQEDTAALIIRQVLLAVEYLHDRQIVHRDIKPDNILVTSLENGGRVVLADFGCAKRMNRGCQRMNSLVGTREYCAPELQPVREKGYSKAVDMWAIGCTAAVLLVGDVHYNQFNRSYERAGAMLEADMEALRISPRPKDFMQRLLDVDESCRMDVKQALQHEWFTHASQAGWFIEKYHDAVEDWTPHVIGESIVIDLDSCQKDSDSMCAGPVSEVDCAPSGPEEIPKLMDECPSREVPDSSWEDLSLSRPQPLNTSTTSMPQMPNLVSFPPKEEAPQIHALEVEKEVGVESDGYEFVSQVRREHVDRHRHRVERKFLYVSTFDGLSGERSAAQIESMIHTKDAIAKSTFTVAAANGLGRSSLIPREDRARADTGQGGPSASKRPFRDESDDLGQVYEEVYNPITGKRKRFAYGRNVELLDRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2R2</accession>
    <name>A0A9X0C2R2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP(+)-dependent dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_001039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794936.1">
        <property type="nucleotide sequence ID" value="XM_056930643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2R2"/>
    <dbReference type="GeneID" id="81620892"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5495923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="29544" checksum="6B1489BE0C300CA6" modified="2023-11-08" version="1">MNPPLPSLTRTWHNASYPAISPHRPESAATGKTIIITGAGSGIGRATAQSFAKAGAQKIVLIGRTEASLRETAKTLTCNTSVQVADVTDEEALCAIAAATGQWDVMVLAAGYISPRLRLGTRRWPSGGKTSSMVMSQVFLPTANPDHATIVALTAAVVFPAARLQKMSGYITSKLAVVKLVEFLAAENPNLVAVALHPGMIDTKVFRESGADPHHLPMDTVELPGDFTVWLTSPEAAFLSGRCAWANWDVDELKAKADEIKSGLLLTSGIYGWPFHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL21</accession>
    <name>A0A9W9WL21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_009077</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786049.1">
        <property type="nucleotide sequence ID" value="XM_056938672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL21"/>
    <dbReference type="GeneID" id="81628922"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000478">
        <property type="entry name" value="Cell cycle protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="86"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="466"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5469459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="510" mass="58407" checksum="248AEB5B78531C11" modified="2023-11-08" version="1">MTTLRGAPAGVFELKRSSSGQEYHANEDRYTLGKDDPRTNDDTSLVESELDEDDGQEDEEEEEVDETVREDMMKLKDTFPEIADRFRLINRIGEGTFSTVYKAEDLQFYGNYRKEWEIFGQAQDREAEEWGKPPSKRRKMNGAPNDQHRPRYVALKKIYVTSSPIRIQNELELLHDLRGCKSVCPLITAFRYQDQVVAVLPYFPHTDFRIQYRTFMVADMRHYLWSLLTALKSVHSHEIIHRDIKPTNFLYNPDLKEGVLVDFGLAERQGSEYSSPCLCSHQSYVRRGRILSSYFSKNPPTNGISSGYPKADSRPSRRANRAGTRGFRAPEVLLKCTSQTTKIDMWSVGVILLTLLGRRFPFFNSADDIDAMIEMASIFGTRRMKAAAAMHGQIFETNLPTIGEKGYSWEKLVKWSSCVEDLTESESQATRLLSGLMELDPSKRLSAEEALEHEFFTEPILHDVEWGGHPEEESVDSEEANERAMDEEAAAAAEEVDELEMILNPEMYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL50</accession>
    <name>A0A9W9WL50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_009119</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786091.1">
        <property type="nucleotide sequence ID" value="XM_056938714.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81628964"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="213"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="508"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="508"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="541"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5469501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="651" mass="70169" checksum="BC848E5A1E78FEC2" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL63</accession>
    <name>A0A9W9WL63_9EURO</name>
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        <recommendedName>
            <fullName evidence="8">2-dehydropantoate 2-reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_009152</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786124.1">
        <property type="nucleotide sequence ID" value="XM_056938747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL63"/>
    <dbReference type="GeneID" id="81628997"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="4">
        <location>
            <begin position="24"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="5">
        <location>
            <begin position="256"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5469534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="47159" checksum="28D07CB02B28471A" modified="2023-11-08" version="1">MSTWSQDAEEISREAKASKLSGRVHIIGLGNAGTFIAHSLAARQSPPPITLLMHQASFYQTFRRKKRSLAVNYNGLDDNRTGFDVEILEDKVWRRIPSREEQHDAQEEDEMYENDQNFHEEEEGHIECLIVCCKAYMTEKVIRDVRHRLSPNSTILLVQNGLGIVEKLNRDLFPDEHSRPHYMQGVLSHGLKKQDSYKIGHVSVGSLILSPVVTSHTPLIEAERDTHWAPTTKYLLRLLTLTPSLVATADTPAGLLQYQLERLTVSSVLGSLGAIHDCKNRDLLHNYAVSRTMRLLLLEISSVIYALPELRGIPGIEDRFSPERLRRLVINVAANRPEDASSLRNDLRYQQNTEIDFLNGWIVRRGEELGMKCVLNYMIVQLVLSRMQMISQREASAVPIDFENVILTGDNTKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WM36</accession>
    <name>A0A9W9WM36_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786228.1">
        <property type="nucleotide sequence ID" value="XM_056938851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WM36"/>
    <dbReference type="GeneID" id="81629101"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5469638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="96" mass="11080" checksum="5F9BA55BC82ADB34" modified="2023-11-08" version="1">MSCEAANPRYITLPSFDSVESLEGMSSYPYSVASRDFYLNLHSDRFPSSLGDPEEEEEEEEEEEEEEEEEEEEEEEEEAVDSLDNGRMISPFLVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQK7</accession>
    <name>A0A9W9WQK7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786417.1">
        <property type="nucleotide sequence ID" value="XM_056938409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQK7"/>
    <dbReference type="GeneID" id="81628659"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="167" mass="18913" checksum="E843B932ED42B190" modified="2023-11-08" version="1">MMVASHDTSTRVCDNIEQHKKDTKTCAARTSRKAEKKRQNDEMEIKKLNEQLEKYHKENQELKIQLVKSQADHSQYKLRAAKAEEALERTQHILTQLMTKLPPSSHLTNNVDTKSGGTLSSASWLTITPRLNGHTQSWPCLSPVSPTSGKDWSGISPSAFELTWKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WRH2</accession>
    <name>A0A9W9WRH2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786463.1">
        <property type="nucleotide sequence ID" value="XM_056938081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WRH2"/>
    <dbReference type="GeneID" id="81628331"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="14"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="529" mass="58723" checksum="EE0EA5892E69A12E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTA8</accession>
    <name>A0A9W9WTA8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786889.1">
        <property type="nucleotide sequence ID" value="XM_056937797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTA8"/>
    <dbReference type="GeneID" id="81628047"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040746488" description="Kinesin light chain" evidence="1">
        <location>
            <begin position="24"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26965" checksum="CF2025F497206014" modified="2023-11-08" version="1">MWLAVRKFASILLIGSNATEVLAEKLILAHAYRAEGNLEEAEKLQVQMVESCMNGPGETLHDTLMSMSELAATYILQGHFMEAEKVDLNVFNTRRMVFSKDHVDMLRGKENLEVTKRRLGRWTEAEKLHVQGSRARSAKFGESHPDTLASRENLASVYHYQGHWLKAKKVYEFLIQVRRIQLGEDHPNTLRNIDQLAAVYCSQGRWREEHSETVSSINRLAGNRTFSVKTHQVLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU19</accession>
    <name>A0A9W9WU19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_008387</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787079.1">
        <property type="nucleotide sequence ID" value="XM_056937987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WU19"/>
    <dbReference type="GeneID" id="81628237"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051563">
        <property type="entry name" value="Glycosyl_Hydrolase_51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776:SF0">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040909182" description="non-reducing end alpha-L-arabinofuranosidase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="9">
        <location>
            <begin position="477"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5475321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="658" mass="72645" checksum="D7971B31FEFECCB9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUD9</accession>
    <name>A0A9W9WUD9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cysteine synthase 2</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cysteine synthase-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">O-acetylserine (thiol)-lyase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">O-acetylserine sulfhydrylase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_008348</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787040.1">
        <property type="nucleotide sequence ID" value="XM_056937948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUD9"/>
    <dbReference type="GeneID" id="81628198"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000096">
        <property type="entry name" value="Related to cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="16">
        <location>
            <begin position="61"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5475282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="430" mass="45785" checksum="6E5DB68769D68779" modified="2023-11-08" version="1">MPDHTTLYVCSAFVAGVSVALICKELLSSHDHAKDSTAANEHPTEAVVARTGPPAIVEGIQGCIGNTHLFRIKSLSDATGCEILGKAEFLNGAGQSSKDRVALSMIEIAEEKGILTPYSGDTIYEGTSGSTGISLASLARAKGYLAHICMPSDQAIEKSNLLLKLGAIVDRVPPAPIVEKENFVNRARALAQAHTESASVSVTSEQDGGLETREIEVRGRGFFADQFENEANWRAHHSGTGPEIYAQCNGKIDAFVAGAGTGGTISGVARYLKPLLPNMTVVLADPQGSGLYNRVRYGVMFDTKEREGTRRRPQVDTIVEGIGINRVTANFEAGKELVDDAVRVTDAQALAMARWLVEKDGIFIGSSSAVNCFAAVKTAQKLGPGHRIVTMLSDSGSRHLSRFWAKAGDVGGAIDTKLEEVLAARDEDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUN5</accession>
    <name>A0A9W9WUN5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_007168</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787568.1">
        <property type="nucleotide sequence ID" value="XM_056936769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUN5"/>
    <dbReference type="GeneID" id="81627018"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="385"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="218"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="783"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="791"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5477024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="844" mass="93363" checksum="C245E4111FE677A3" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUZ1</accession>
    <name>A0A9W9WUZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_007354</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="51490" checksum="BD8FAE6BB0669D82" modified="2023-11-08" version="1">MGFKEVFRNRSGLRIDNRKTTSASTLTLRQSLWPLSLVTILFFLWGFAYGLLDTLNKHFQNTLHIDRTRSAGLQAAYFGAYPLASLGYANWILRHYGYKTVFIFGLTLYGIGALCMWPAGLNQSFGGFCGATFVIGSGLGSLETAANPYLTVCGPPRYAEIRINFAQSFNAIGTVVGPVLGSYVFFTGTNDTVTALQRVQWVYLAIGIFVFCLAAVFFVSSIPEVTDEDMAFQVAETHVDEQEKPFWKQYKLFHAALAQFTYTGAQVAIAGYFINYAEDTWPGTTGAKGAKLLAGAQGAFAAGRFLGSGIMKYVKARWVFGIYLSCCVAFLATSVTQRNQAGVAMLYLVLFFESVCFPTIVALGIRGLGRHYKRGSGVIIGGVCGGAVVPPILGHVADMKNNTGFAFIVPTMFMVVAWTYAVAVNFVPSYKSTVDKVGASRVGLQDQNAKDIEAASTTAGDHVVPAKREKAGDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9W9WVF7_9EURO</name>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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            <dbReference type="EMBL" id="KAJ5477465.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
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        </recommendedName>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="542" mass="61427" checksum="E45335FC2767D743" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2I8</accession>
    <name>A0A9W9X2I8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056936555.1"/>
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    <dbReference type="GeneID" id="81626804"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5481060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="213" mass="22774" checksum="930BEDF9F6319406" modified="2023-11-08" version="1">MSAYAPQSGVRFIVSHGVFQHAYDICNPTGQAEFHVDVSHWTPGKADMTFHKGADSSHPIIGIAEFQHLSKDAELGLVDPSRPGGMERIPLPCDTFMTVQYAFQVIFPGEHHRRTYTWKRTRSHGFGSQALKLVDETGRVIAVYSAGGGLTSRTGQMDLYVNYGEKFQLIALMSGLALQEKLHRSRKHGAAGVAGGSGGLFTAGAAGAAGAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2L4</accession>
    <name>A0A9W9X2L4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_006203</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="15"/>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788729.1">
        <property type="nucleotide sequence ID" value="XM_056935805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2L4"/>
    <dbReference type="GeneID" id="81626054"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 15" id="KW-0288">FMN</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 15" id="KW-0520">NAD</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="16">
        <location>
            <begin position="379"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5482757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="496" mass="54230" checksum="C87505032D24E6C0" modified="2023-11-08" version="1">MLSRAAAPSSSTFASISSRSLRAQGAATRAFATVQEAPPVRHHGGLRDQDRIFTNLYGHHAPDLKSSMKYGGDWHRTKDIVLKGDDWLISEIKASGLRGRGGAGFPSGLKYSFMNTKDWDKDPRPRYLVINADEGEPGTCKDREIMRKDPHKLVEGCLVVGRAMNANAAYIYIRGEFYHEATVLQQAINDAYAAGLIGKNACGSGYDFDVYIHRGMGAYICGEETSLIESIEGKAGKPRLKPPFPAAVGLFGCPSTVTNVETVAVVPTIMRRGASWFSSFGRERNAGTKLFCISGHVNNPVTVEEEMSIPLRELIEKHCGGVRGGWDNLLAVIPGGSSTPVIPKSVADDQLMDFDALKDSQSGLGTAAVIVMDKSTDIVRAISRLSTFYKHESCGQCTPCREGSKWTMQIMQRMETGNAREREIDMLQELTKQVEGHTICALGEAFAWPIQGLIRHFRPELEARIRQYEKEVGGTPFAGGWKPSARAEGKLISPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2Q5</accession>
    <name>A0A9W9X2Q5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBM21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788750.1">
        <property type="nucleotide sequence ID" value="XM_056935826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2Q5"/>
    <dbReference type="GeneID" id="81626075"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="326"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5482778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="766" mass="84309" checksum="4ADF1C46E53A0B11" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2R7</accession>
    <name>A0A9W9X2R7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 11">D-xylulose reductase</fullName>
            <ecNumber evidence="9 11">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Xylitol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_006896</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 11">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>xylitol + NAD(+) = D-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 or 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 11">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="9 11"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788432.1">
        <property type="nucleotide sequence ID" value="XM_056936497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2R7"/>
    <dbReference type="GeneID" id="81626746"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to D-xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0859">Xylose metabolism</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="16"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5481002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="357" mass="38203" checksum="E1CF46D64D169678" modified="2023-11-08" version="1">MTSTQTSKNLSFVLEGIHKVKFEDRPVPELKDPHDVLINVKYTGICGSDVHYWEHGAIGNFVVKEPMVLGHESAGVITQVGSAVTSLKVGDRVAMEPGTCCRRCEPCKSGKYNLCENMAFAATPPYDGTLAKYYILPEDFCYKLPESMSLQEGALMEPLSVAVHIVRQAQVSPGQSVVVFGAGPVGLLCCAVAKAFGASKVVVVDIQEARLDFAKEYVTPLTFVPGKVAATENAERMRQEHGLGAGADVAIDASGAEPSVHTGIHVLRNGGTYVQGGMGRSEIQFPIMAACSKELTLRGSFRYGSGDYKLAVELVSTGKVNVKKLITGTVKFEEAENAFKDVKQGKGIKTLIAGIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2U1</accession>
    <name>A0A9W9X2U1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dimethylglycine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_006129</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788655.1">
        <property type="nucleotide sequence ID" value="XM_056935731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2U1"/>
    <dbReference type="GeneID" id="81625980"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032503">
        <property type="entry name" value="FAO_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16350">
        <property type="entry name" value="FAO_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase central" evidence="5">
        <location>
            <begin position="381"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="GCVT N-terminal" evidence="3">
        <location>
            <begin position="438"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="4">
        <location>
            <begin position="750"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5482683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="853" mass="94231" checksum="E73243347D2C5D15" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2W2</accession>
    <name>A0A9W9X2W2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine dehydratase</fullName>
            <ecNumber evidence="12">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_006690</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="12"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788226.1">
        <property type="nucleotide sequence ID" value="XM_056936291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2W2"/>
    <dbReference type="GeneID" id="81626540"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04906">
        <property type="entry name" value="ACT_ThrD-I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04907">
        <property type="entry name" value="ACT_ThrD-I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1020.10:FF:000001">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000008">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1020.10">
        <property type="entry name" value="Biosynthetic Threonine Deaminase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038110">
        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005787">
        <property type="entry name" value="Thr_deHydtase_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01124">
        <property type="entry name" value="ilvA_2Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006674">
        <property type="entry name" value="PRK09224.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF11">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51672">
        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT-like" evidence="13">
        <location>
            <begin position="385"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="ACT-like" evidence="13">
        <location>
            <begin position="481"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5480796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="562" mass="61573" checksum="F826245AB4849CEA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2Z5</accession>
    <name>A0A9W9X2Z5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788730.1">
        <property type="nucleotide sequence ID" value="XM_056935806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2Z5"/>
    <dbReference type="GeneID" id="81626055"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF135">
        <property type="entry name" value="SET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G11040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5482758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="673" mass="75619" checksum="2CA8CBB5ACEA22EE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3Q4</accession>
    <name>A0A9W9X3Q4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788957.1">
        <property type="nucleotide sequence ID" value="XM_056936033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X3Q4"/>
    <dbReference type="GeneID" id="81626282"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5482985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="614" mass="66918" checksum="0347E7E9E9885027" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X400</accession>
    <name>A0A9W9X400_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788796.1">
        <property type="nucleotide sequence ID" value="XM_056935872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X400"/>
    <dbReference type="GeneID" id="81626121"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="522"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5482824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="874" mass="98916" checksum="622798AA54CD52B5" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X516</accession>
    <name>A0A9W9X516_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7729 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789231.1">
        <property type="nucleotide sequence ID" value="XM_056935359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X516"/>
    <dbReference type="GeneID" id="81625608"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460:SF1">
        <property type="entry name" value="C6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24855">
        <property type="entry name" value="DUF7729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7729" evidence="1">
        <location>
            <begin position="155"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5483961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="400" mass="42285" checksum="490DBEAA6B0823A1" modified="2023-11-08" version="1">METVAGPDQCIGSHIANHSGPTPTVNTRSFFKRRESHFDRPRRCSILSMTICQTLLLCLIILCLSPQSALAQTTVGISNSSSSLGSASAPAPCGEISTDVPATEALLVSIAEHAQLHEHKKHVDGTEPIYTAENGVLLLKRSPSSADNSSSYPDVPTAFDTLSNNFANASCVSFFNQFRSNSTFTDCLAVSLLLGNSNSFFHVLTSAVDTSHVLDAACAQPVDKCASVLTSLAKQLLHDDHCAQDYNSGNAVVQSVYQELIAYEPVYHVSCLTDPATKSYCFVDAVTNTSAPNNYNVYFVPIGSTLTASGPITCNKCLKDTFDVYAQWATVNGQSLDTTYVPSAILINNYCGAGFANTNVTVGALKATAAGAGQALQPPDSRLLVSFAAVLIGIAISGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X518</accession>
    <name>A0A9W9X518_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_005803</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789277.1">
        <property type="nucleotide sequence ID" value="XM_056935405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X518"/>
    <dbReference type="GeneID" id="81625654"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
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        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="6">
        <location>
            <begin position="208"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5484007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="284" mass="32077" checksum="465B72507F5D64EE" modified="2023-11-08" version="1">MAQPLKKKGNEFFVKGDYVTAEDFYSQAIAADSHDPTFFTNRAVTRIKLGKWQDVETDARAAINLYDKKDPAALKSMGYLVEALIALGRPQEAHDVALPAYELSLNTKHAQAEKISGLVLRAKKALWEARETARLHEMDETLKRLEDLITAELARTEKELAGQLERHELGESEYQKSLKATQADAQKQIEHIREVFRISSKGEVQERVVPDYLVDGITFEIMHDPVVTPSGTTYDRVGIIKYVEKSGVDPLTREPMTVKDLRPNYALKAACEEFLSKNGWAVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X523</accession>
    <name>A0A9W9X523_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell division control protein 73 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_005819</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789293.1">
        <property type="nucleotide sequence ID" value="XM_056935421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X523"/>
    <dbReference type="GeneID" id="81625670"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11990:FF:000003">
        <property type="entry name" value="Pol II transcription elongation factor subunit Cdc73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="6">
        <location>
            <begin position="301"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5484023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="489" mass="52759" checksum="D6D5D448AA6E36AA" modified="2023-11-08" version="1">MSASTAQDPLLSLRRAIAAGTLPTPTTSSELSDQLATEDLAQATHLYFSQPSPHTFSLDTPTRFVSNATNTAVDLRSILFAWQKKDVAIPEYIASAQELSEALKKKGPKEDGQLSEVQNLVFVERLDLITWLEGASDESEHIKPLEGAAAAAEAAVAAGQAQAEAAAGVASGVTGGVPVISSAGAAAAGQVGRPQKQINPRLQEIYAEERKTGDRNTLLRGTKPTVCLEISYIRPWTEEKANEALRAKQDFTHARKLDAVFFDRSRDRPGQAGAKPGVKSTSMVSAPSAGLPLPSRKPSSRPDPIILLSPSASSLIRMSNIKSFLQDGIFVPPDHPTLSMSTEANFMELKRPLRLKNGPSNSAVGAGGSAGLKPTKFILVDGTTNFKPEYWSRLVAVFTTGQTWQFKSYKWSSPPELFKHATGIYVGWRGDDVPATVKGWGRGVESFALERWDEKGGIHGGGRWRDREVVEGIWTAIEEGMKLRGWGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X540</accession>
    <name>A0A9W9X540_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">V-type proton ATPase subunit e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789323.1">
        <property type="nucleotide sequence ID" value="XM_056935451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X540"/>
    <dbReference type="GeneID" id="81625700"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040966317" evidence="1">
        <location>
            <begin position="21"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5484053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="90" mass="9836" checksum="0D57FB27D132BC12" modified="2023-11-08" version="1">MANGWSLLVGLIVIVALSLAAWFFSPKGENQTNCFHGPATPSYRAQEGQYSTWFSTGVKNDATDVLPFRYRDRPGALALDGCHTSQLTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X551</accession>
    <name>A0A9W9X551_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_005747</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789221.1">
        <property type="nucleotide sequence ID" value="XM_056935349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X551"/>
    <dbReference type="GeneID" id="81625598"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048938">
        <property type="entry name" value="ATPD_C_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21334">
        <property type="entry name" value="ATPD_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="35"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase subunit delta C-terminal" evidence="15">
        <location>
            <begin position="121"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5483951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="164" mass="17578" checksum="4F51F4D970210EC8" modified="2023-11-08" version="1">MNSFRFARSALRARSAFSAPVQRRGYAEAVNDKIKLSLTLPHQTIYRSTGVTQVNIPAASGDMGVLANHVPSIEQLKPGLVEIVEEGGATKQYFLSGGFAVVQPDSQLSINAVEGFPLEEFSAEAIRAQIAEAQKIAGGNGSEQDIAEAKIELEVLETLQAHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X582</accession>
    <name>A0A9W9X582_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_005739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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            <strain evidence="2">IBT 30728</strain>
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                <person name="Nielsen M.R."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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    </evidence>
    <sequence length="764" mass="82404" checksum="6E1A224383F6D8C7" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5D1</accession>
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        </alternativeName>
        <alternativeName>
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        </alternativeName>
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            </authorList>
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            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF(sconB) E3 ubiquitin ligase complex.</text>
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        <text evidence="2">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
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    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="668" mass="73701" checksum="DC2A9B610305993F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5N2</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">N7539_004750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
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            <authorList>
                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
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            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056934352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5N2"/>
    <dbReference type="GeneID" id="81624601"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02453">
        <property type="entry name" value="TIGR02453 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="CHROMOSOME 12, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452:SF1">
        <property type="entry name" value="DUF2461 DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5484762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="476" mass="53607" checksum="9821507141FE70E7" modified="2023-11-08" version="1">MPRRPSKAAVTSPPSVVSGTAQKRRASARLSAAQNEIKRVKSSSILLDQSVKSTAKTSKYFEADNSVESETATSEPSEPEEDDSESAYEEGDPSDATAEEESEPEEPSESEEDDKKSRPRSKKNARSSNIDSDLLKGKELWREGVRTGLGPGKEVFIPKPKARDPGKVPYQDERLHPNTRLFLIDLTKNNDREWLKGHDPDYRAAKKDFETFVETLTPKIVEKDGTIPELPVKDLIFRIHRDVRFSKNPLPYKNHFSAAWSRTGRKGPYAAYYLHFQPGSSFLGCGLWCPEAGPLAALREDIDENVDSWLEVLGEPLLRREFLNGASDDHQEIMKAFAHANRESALKTKPKGYDADHKSILLLRLRSFTLARPLTDDDLLSANTQDRIATLIEILEPFVSDLPRLLSQRAFCRKTTLTLLTACFCHHVKSIGQGQWLPGCVEYCWNHPTFRAKSSITDVDYMEQVTYLNSVVMPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X654</accession>
    <name>A0A9W9X654_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Disease resistance R13L4/SHOC-2-like LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_005006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789802.1">
        <property type="nucleotide sequence ID" value="XM_056934608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X654"/>
    <dbReference type="GeneID" id="81624857"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019487">
        <property type="entry name" value="RAM_signalling_pathway_SOG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF46">
        <property type="entry name" value="LEUCINE RICH REPEAT-CONTAINING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10428">
        <property type="entry name" value="SOG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="158"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="394"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="619"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="680"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="705"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5485018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1002" mass="109780" checksum="21785FBB3EC24AB5" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X694</accession>
    <name>A0A9W9X694_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CLPTM1 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_004912</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789708.1">
        <property type="nucleotide sequence ID" value="XM_056934514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X694"/>
    <dbReference type="GeneID" id="81624763"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="595"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="623"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5484924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="73153" checksum="F5A94D77ABB1B4B1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6F2</accession>
    <name>A0A9W9X6F2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA repair protein rad9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789967.1">
        <property type="nucleotide sequence ID" value="XM_056934773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6F2"/>
    <dbReference type="GeneID" id="81625022"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25431" checksum="066F7BBBF40514B8" modified="2023-11-08" version="1">MHIAINLKDFKAAIAHAETANATITARYTYPCKPLQLTYDFEGVSAEFTVMTRGEVDGDFAPDSSRSGIRELSQRQTPGAPISVQRDRISREATQNGQMPPPPPPPARSIKPLQGSSTQENLSRSMASERPTASSLSMEFDSLFVPADDDRQWDEMNEEEEEEPQDILGWDASGRADAFAATLRDEEPGLSRNESKTDEAETEDMRIPPTQRISQVSFFWIAFVCVRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6R5</accession>
    <name>A0A9W9X6R5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_005382</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790178.1">
        <property type="nucleotide sequence ID" value="XM_056934984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6R5"/>
    <dbReference type="GeneID" id="81625233"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000726">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="484"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="673"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="67"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="122"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="223"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5485394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1122" mass="127341" checksum="C2BCAC1AFCA5DA17" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7A6</accession>
    <name>A0A9W9X7A6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790203.1">
        <property type="nucleotide sequence ID" value="XM_056935009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X7A6"/>
    <dbReference type="GeneID" id="81625258"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051870">
        <property type="entry name" value="Elongin-A_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010684">
        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141:SF76">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="297" mass="32408" checksum="77006070E1F00A75" modified="2023-11-08" version="1">MEVLSPHLAETDQELWLELIKRDIPQWQKYELPQNSNSWYEIYCDLQAEVQRELEADAAKLKRAIDGIQSERAQLQPKVMNSIPRGVRGSRGRVVPRGPMSSADARKKSAIFAPQRRNPALIVPTKHLNNRATQITKAPLSLIEAHRRPADPPAPTREAAAGRISVPGKMLSKSTRPLPALHSSSALADREARLRAIAAGKPIPPRPLSNSAPTGSTTDRPRRAGNASIPTKESHSPVKKAIPKRKATSPPPQSAAAGGSSTALSGRTAPEMTGRPGIARKRSEVDIFLRPRKKRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7E6</accession>
    <name>A0A9W9X7E6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790481.1">
        <property type="nucleotide sequence ID" value="XM_056935287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X7E6"/>
    <dbReference type="GeneID" id="81625536"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5485697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="275" mass="31494" checksum="DD5762C3C0344934" modified="2023-11-08" version="1">MSLRAFPLSQTRAPWRDLISSHLEKQKEYDFTVATVGYDAKQRIVPRVRTCGFRGFFPELKLHPSGQKDLDQQVEDGGNPPLFESDLLSFTSDIRMEKLRQLDSTGNSIEAMFWLKEVMVQWRIKGQAYYIGSPAAESGKESDLQAQLFKALRRKDDYHGDEKADFKKWTWDKAITKYFANHSPAMRGSFRNPPPGQPRTQQLSNPDLSLGQKVSDLHDPVARGNFRLVLILPEEVEQLDLSNGDDPRRRKWTLVGGDGDVERTGGQWQESELWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7S9</accession>
    <name>A0A9W9X7S9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">N7539_005634</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790430.1">
        <property type="nucleotide sequence ID" value="XM_056935236.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81625485"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000026">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000047">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1103"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1146"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1188"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1220"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1249"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="238"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="22">
        <location>
            <begin position="1032"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="615"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="615"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="615"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="616"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
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            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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            <position position="888"/>
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            <dbReference type="ARBA" id="ARBA00034036"/>
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            <dbReference type="ARBA" id="ARBA00051303"/>
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            <dbReference type="PIRSR" id="PIRSR606539-3"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAJ5485646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1363" mass="152377" checksum="00D951B382129869" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XC50</accession>
    <name>A0A9W9XC50_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxy-cis cis-muconate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790585.1">
        <property type="nucleotide sequence ID" value="XM_056933044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XC50"/>
    <dbReference type="GeneID" id="81623293"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000244">
        <property type="entry name" value="Carboxy-cis,cis-muconate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF4">
        <property type="entry name" value="CYCLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="360" mass="40295" checksum="41AFEA0C493757EA" modified="2023-11-08" version="1">MKHHLMIGTWTAPGRIYTVQFDDEALTLDLVKKTNIPEAEPISWMTFSHDKKTIYGAAMKKWNSFAVKGPTDIEHQVSHPVAGHPLAASADTNTRAIFVLAAHQPPYNVYGNPFYKHAGYGNVFSVTADGALDTNVQNYEYDPNTGIHGMVFDPTETYLYSADLQANKIWTHIKDATTGQLTLLDCLEAPAPGDHPRWVEMHPSGKYLYALMEAGNRLAVYVIDERTHKPVFTHITYPLLPPGLPPRNKYRGDVTFTTKSGNYLFATTRSNHFDVTGYITAFKLGPSGEILQQLFINPTSTSGGHSNAVSPCDFSDEWLALCDDQLGFVEMYRWQDEKLARVARVDIPEQGFGMNAIWYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCM1</accession>
    <name>A0A9W9XCM1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Na(+)/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_003488</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790631.1">
        <property type="nucleotide sequence ID" value="XM_056933090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCM1"/>
    <dbReference type="GeneID" id="81623339"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013928">
        <property type="entry name" value="Cation/H_antiporter_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08619">
        <property type="entry name" value="Nha1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="26"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Alkali metal cation/H+ antiporter Nha1 C-terminal" evidence="14">
        <location>
            <begin position="463"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="476"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="594"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="842"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="601"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="735"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="842"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="894"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="997"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1041"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5488598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1079" mass="120099" checksum="5111B4F818EF16A7" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCR3</accession>
    <name>A0A9W9XCR3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791008.1">
        <property type="nucleotide sequence ID" value="XM_056933467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCR3"/>
    <dbReference type="GeneID" id="81623716"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5488975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="300" mass="33862" checksum="17802269EBE1E379" modified="2023-11-08" version="1">MLHIELFYHLLSDTLPGLDVQLGETDLVGLVPHLLKAPYMVNELLAFSALHLSTRHPERCKYYRTLATQLQTHAIANFQEGGLVIDQETCVPAVMFSSIVGLHALCDSLVHREKDFAHFVDKFVHCFRLHLGVRTVFTEAWAMIRQSVLKPLLADVERQHHFDGRLGLGCAKLLRLVQAANLGDHLTRIYKQAIEQLQVSANVFIPSAIAGSQFFGAGWPLLVCSEYNDLLLQRRPEALVILAHYAIMLQCCRGSWIVGDGGHYIIQSTRDWLGSEWAEWLEWAVTDVEDPVKLLLQVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XD39</accession>
    <name>A0A9W9XD39_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791203.1">
        <property type="nucleotide sequence ID" value="XM_056933662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XD39"/>
    <dbReference type="GeneID" id="81623911"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="753" mass="85831" checksum="555BE154C19153A8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XD76</accession>
    <name>A0A9W9XD76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790916.1">
        <property type="nucleotide sequence ID" value="XM_056933375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XD76"/>
    <dbReference type="GeneID" id="81623624"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="137" mass="14870" checksum="6EA3B088D2D20111" modified="2023-11-08" version="1">MGLQDADSWVLHLHLGLANSIRTTVNLVLACGTSLDWHRRRSTPPRPPSVGTGTPKSDRVFSPHGIPSLGQANHELGDWQRDMLAPSSLIDSILVTLGTAQKKADAAMQEMREIMHIETPCGRGIATTNRKLLDGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDB6</accession>
    <name>A0A9W9XDB6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_004136</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ORC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791279.1">
        <property type="nucleotide sequence ID" value="XM_056933738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDB6"/>
    <dbReference type="GeneID" id="81623987"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000024">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000199">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041083">
        <property type="entry name" value="AAA_lid_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17872">
        <property type="entry name" value="AAA_lid_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="12">
        <location>
            <begin position="96"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="259"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="587"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5489246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="797" mass="87840" checksum="E7FC83E533EDA55B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDR4</accession>
    <name>A0A9W9XDR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_003762</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790905.1">
        <property type="nucleotide sequence ID" value="XM_056933364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDR4"/>
    <dbReference type="GeneID" id="81623613"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001788">
        <property type="entry name" value="GMF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5488872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="139" mass="15829" checksum="CAF351D0B717FAEC" modified="2023-11-08" version="1">MPGLYSFSPETKERLRKFRLSSSRAKEPQAQIYEIDKNTGEIRPKNDETYTSMMDVADDLPETTPQFIVLSHPLTLKDGRLSVPYVLLYYKPENCKTDTMYQYANAVELMRTTAGVNRLVPVESEDDVISIESKLAGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDU3</accession>
    <name>A0A9W9XDU3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_003807</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790950.1">
        <property type="nucleotide sequence ID" value="XM_056933409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDU3"/>
    <dbReference type="GeneID" id="81623658"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="8">
        <location>
            <begin position="98"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5488917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="221" mass="24123" checksum="53645A060D5C2E87" modified="2023-11-08" version="1">MEMYKDDFKFPPQGSNRLRIIVVGAGIAGLSAALVAPNAARILGRFGVLREVVEKANVLDRNSLRRYANDEELGTAPLMPEIGLTCRLCALNSHAALPSWVENRTVLMGDACHSMLPYVAQGAAQAIEDAGVLACVLSLGGDEVDIPTILKVYERVRKDRAEKFQNGAAETRLALHLPEGEKQRERDEAMKSVDKSPDLLADQEWQAFMCGEDESSLASIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF84</accession>
    <name>A0A9W9XF84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_002593</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792155.1">
        <property type="nucleotide sequence ID" value="XM_056932196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF84"/>
    <dbReference type="GeneID" id="81622445"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000013">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="174"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="586"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5491026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="952" mass="107334" checksum="88CE895CC1495DED" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFA6</accession>
    <name>A0A9W9XFA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_002701</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792263.1">
        <property type="nucleotide sequence ID" value="XM_056932304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFA6"/>
    <dbReference type="GeneID" id="81622553"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF3">
        <property type="entry name" value="POLYAMINE TRANSPORTER TPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5491134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="526" mass="56832" checksum="F190AA744AF9EC0B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFD2</accession>
    <name>A0A9W9XFD2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secondary metabolism regulator laeA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792388.1">
        <property type="nucleotide sequence ID" value="XM_056932429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFD2"/>
    <dbReference type="GeneID" id="81622678"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="185" mass="20014" checksum="BD941DF6C77AF68A" modified="2023-11-08" version="1">MLTDEQSGRNRLPPMLTSPPPPKRHKSESTSASDAGRASRYYHAGSVPSSERYYSSSIPATDRFQPSSIPPHDRHPSASIPATDRYQCSPVPAGERSRQTSTAMDIYTITDRNPADKDGDRRTGRFLSNGSVASQRSQASRASGSSPPVIITNRKYVVLPSFPSSQTNASPIQVSGPLFTASIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFE0</accession>
    <name>A0A9W9XFE0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002808</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792370.1">
        <property type="nucleotide sequence ID" value="XM_056932411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFE0"/>
    <dbReference type="GeneID" id="81622660"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022596">
        <property type="entry name" value="GPR1/2/3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11970">
        <property type="entry name" value="GPR_Gpa2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="44"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="389"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5491241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="420" mass="47398" checksum="0F39E04E4EBACBF5" modified="2023-11-08" version="1">MSGMFLRSLLARAIQDDISSRSGAALTLDIDPLPIAQHRGLIAVSIMACLSLIATLTLLAFITFRLIFWRRNYQRYIGYNQYVILIYNLVLADFQQSLAFLVCLKWIATNKIEAGTVACFLQGLWLQIGDPGSGLFVLAIAFHTFLLVVWGYKMSHKMFVCFVIGVWVFIGIISVIPIALHGYRVFIPSGAWCWISEEYEPVRLWTHYIWIFLAEFGTVMLYAIMYMQLRRQIAASAILGNSQLESLKRLRRVVGYMTIYPIVYIILSLPLAAGRMSTANGYAPSITFFCCAGAIITSSGLVDVILYTLTRRNLIIDSEPSQDRSYNKFASSRGRYGENHLTTITAADPKTRTVVGGTNHDRDGSTDNIVQPGIEMDNIGKVYQETTIEITTEPAYPPEVESERSSKDDFKDNPSRRWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFL4</accession>
    <name>A0A9W9XFL4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">dTTP/UTP pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_002927</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792489.1">
        <property type="nucleotide sequence ID" value="XM_056932530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFL4"/>
    <dbReference type="GeneID" id="81622779"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5491360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="275" mass="29898" checksum="B731CAA6313193E6" modified="2023-11-08" version="1">MSDSKDSLLGNEDPIDPPPAYDPPKPTRGALPRPPPLGLPVLNALRNKRVILASQSPRRRQIISFLGLPNIEIIPSNAEENLPKTLTPFEYVLGTATKKAQAVYEQEISNETAGEPALILAADTVVVNIEAGTILEKPRSEAHHVSMLRALRDARDHKVFTALVAMAPLASARQPGYAMESVVEETNVRFDGEVTDELILAYVRTREGADKAGGYGLQGLGSILVEKIDGTADNVIGMPLKATLKLIETVMARADDEDRLPDDPIFEEDEDEDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG05</accession>
    <name>A0A9W9XG05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_003013</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792575.1">
        <property type="nucleotide sequence ID" value="XM_056932616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG05"/>
    <dbReference type="GeneID" id="81622865"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5491446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="518" mass="58956" checksum="C8D24283546EDF34" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG57</accession>
    <name>A0A9W9XG57_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">U5 small nuclear ribonucleoprotein component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_003119</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792681.1">
        <property type="nucleotide sequence ID" value="XM_056932722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG57"/>
    <dbReference type="GeneID" id="81622971"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16264">
        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001452">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="158"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5491552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1011" mass="113015" checksum="D6797F3ACFE7A4BA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG63</accession>
    <name>A0A9W9XG63_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Decapping nuclease</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_003186</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs. Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates. Stimulates exoribonuclease activity of Rat1, allowing it to degrade RNAs with stable secondary structure more effectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792747.1">
        <property type="nucleotide sequence ID" value="XM_056932788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG63"/>
    <dbReference type="GeneID" id="81623037"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="8">
        <location>
            <begin position="22"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5491619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="399" mass="45765" checksum="DE3972734CE941CE" modified="2023-11-08" version="1">MSRALFEIQPIARFGGVNTTIRRPREIACFSYDQERRFSLGDASMAYYYPPNLPADLNIGFDTFQKLDDSADEHLDALLETIMAMEKETGKKCETDVITWRGMMTKIRDEYNMLSRNIVRNTTLNASSQDQSIVLTSHAMLSTRFIEEHNAYKNQQKHIQKNQRMPPGMASQELMMYWGYKFEALSVLRKPWDETSRAEIEGRQDEVVNNSAQYCSVVKTGMGHVRMVLGGEVDAVWDCKPVLKEHPIHWVELKTSAEIRNDRDMVKYERKLLKFWAQSFLLGVPKIIVGFRDQQGIVRRLEELDTASIPGKVKSVGRGSWDGNICINFAAGFLDWLKQVVQGEGVWRIRKLEKSHVIEVFKIEETGHGDILSSSFKSWRESLGRTTDDSSEHPPAQSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGM6</accession>
    <name>A0A9W9XGM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793016.1">
        <property type="nucleotide sequence ID" value="XM_056930985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGM6"/>
    <dbReference type="GeneID" id="81621234"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038903">
        <property type="entry name" value="Allergen_Asp_f_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25312">
        <property type="entry name" value="Allergen_Asp_f_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040957276" evidence="1">
        <location>
            <begin position="20"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="341" mass="36321" checksum="B95DE16355C4D43E" modified="2023-11-08" version="1">MLVKNSLLLAAALTAGSAAARMHGHERRHAHHKAQMEPIVEVEKRAVGDVVHAVIDGVLQTWINEWSGESATSSATTFAVATSAPTTIVSVPTITAAPTHSQAPSAIESMVPAHTATPGSSGSWSDLPANGQYTRAGFGVNNCDKSQDGALGVMWSGNTGLPWGSNIIEVEENVANQYKHVVRFEGSESDDWTVVVWNKKGPDGKMDGFFHPNKALTFTVGAGQVKYVAIDTDSTGGWAAWKGDEMPLSQYGSYAATWGEFTMRDSPNFTSWDVSCIQAQNAGKEIQGMRICQHDGSTCSTITKNMGTVQDAYTSAETDINGIGGNVKVEAIRLVVNLDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGR6</accession>
    <name>A0A9W9XGR6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_002869</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792431.1">
        <property type="nucleotide sequence ID" value="XM_056932472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGR6"/>
    <dbReference type="GeneID" id="81622721"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000039">
        <property type="entry name" value="Protein translocation complex component (Npl1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000169">
        <property type="entry name" value="Protein translocation complex component (Npl1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="105"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="651"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="651"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="690"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5491302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="714" mass="80254" checksum="B8ED8257B27F5268" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGV4</accession>
    <name>A0A9W9XGV4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793178.1">
        <property type="nucleotide sequence ID" value="XM_056931147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGV4"/>
    <dbReference type="GeneID" id="81621396"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="59" mass="6439" checksum="58491000316FCCD3" modified="2023-11-08" version="1">MTGKSELRPATAVIPIWENHATRDAIHIHAKPDQERPMAAQGSQVALPTAERVQENTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH67</accession>
    <name>A0A9W9XH67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792935.1">
        <property type="nucleotide sequence ID" value="XM_056930904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH67"/>
    <dbReference type="GeneID" id="81621153"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF4">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040775002" description="Alpha-L-rhamnosidase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="2">
        <location>
            <begin position="736"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5492555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="843" mass="90532" checksum="802D18842796531B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHJ8</accession>
    <name>A0A9W9XHJ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_001734</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793368.1">
        <property type="nucleotide sequence ID" value="XM_056931337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHJ8"/>
    <dbReference type="GeneID" id="81621586"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048485">
        <property type="entry name" value="COG5_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049176">
        <property type="entry name" value="COG5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20649">
        <property type="entry name" value="COG5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10392">
        <property type="entry name" value="COG5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5492988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="480" mass="52011" checksum="F1EFA307B79EADFC" modified="2023-11-08" version="1">MVEGEPSYIDYEAFLDPDFSPASFANTLVLSTNNATDTPLDLSTPLSRVLFDLQEIDTHIHTLTTKSALPLLSHTRDQTEAAERILKEAGSQIASVTQGYERLEKEVVQKWKAADEARIAAENSLATVRLARAVARSLTLGRQLENQIGEITGKGTGQPSPAGADGATTAREGIRALERAAYTILSLRQMFSATGEDDEGYGLQRVKVMRTLRNELLLPAENVVKARAQQIINRFSLASPMATTSRTPAPSSYKQVRDARARLGPAAATLYLLSPIPRDGATVAEFKPDLFLSTLQGYMQTAIMTSVNGLAKGLSQLPTMDRTLNDVASRCQDIAALESFLRNLRAPTHPLLVHSETNSAPTTGVESAARGSQSNLLQPLLNALDTSSLPSYYWRSVASSLSPRVQEIMTRGGVSARTLRSNRDRLRTEIKQCVLRACQISAASLSADKSRSEEEEVAGAGNWEREAAVMVSSIVGPLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHV9</accession>
    <name>A0A9W9XHV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793533.1">
        <property type="nucleotide sequence ID" value="XM_056931502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHV9"/>
    <dbReference type="GeneID" id="81621751"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5493153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="141" mass="15991" checksum="4D329EB4C24883F4" modified="2023-11-08" version="1">MAWYSILPPQLIQFESWVVRVSLLLALFTIGPWAALIAFDACLYLYRMIIWEMPGVGGRARGQQRPRAPSLQERPDGQRRAFGVFGSETDIANGDLKRRENGRSERRESLAKTEPSPIEDKTPYKLDSLGDVAKRRMASPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIJ5</accession>
    <name>A0A9W9XIJ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793389.1">
        <property type="nucleotide sequence ID" value="XM_056931358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIJ5"/>
    <dbReference type="GeneID" id="81621607"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040915345" evidence="1">
        <location>
            <begin position="20"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="90" mass="10262" checksum="1F28E86F21D76412" modified="2023-11-08" version="1">MERISIAGVLLSWWPLALRWGGQEDQDRKWTGIDSFLNPQFPHVTALPSWKLENPVVEVNDIDFKCRLDSQLLRAIGHPASAHERQDLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIW8</accession>
    <name>A0A9W9XIW8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_002131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793765.1">
        <property type="nucleotide sequence ID" value="XM_056931734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIW8"/>
    <dbReference type="GeneID" id="81621983"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="74"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5493385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="336" mass="37800" checksum="56B23C509B195019" modified="2023-11-08" version="1">MASSRWWLYIQAVVWRFLMGIGMVLHTLAPPRPPRPTFTRTLHSETSTSVVIHFYCPPDYHQQRRQGHRYPVAVNFHGGGFTLGSATDDGRWSAAVVEQVGAVVASVSYRRAPEHPFPTAVDDGVEALLYLAANASDLALDVSRVALSGFSAGGNLAVTVPLRLRGRIVSAIKEQLGRADSTQQLMNQTNELRIVALFCWYPILDFLESRDHRRAMSIMPNKTLPKFFTNLFDEAYLPNIEDRSSPYASPVRASDEALHDALPDDVFLFICEWDMLMKEGQTFVRRLEGLGKKVRSMMIAQAQHAWDKSANPFRDQGSVDIHYRDACADMKAIFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XL73</accession>
    <name>A0A9W9XL73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794075.1">
        <property type="nucleotide sequence ID" value="XM_056929782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XL73"/>
    <dbReference type="GeneID" id="81620031"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041011425" description="Hydrophobin" evidence="2">
        <location>
            <begin position="19"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="159" mass="16083" checksum="3FA0009EF8310A15" modified="2023-11-08" version="1">MQFTTSSIFLGLAALAVALPADQSTSANGLRAQNDSDVRWHVPSSMTVQEAQAKCGDQAQLSCCNKATYAGDTTDVNSGIGGGLLSNLIGSGSGAEGAGLFEQCSKLDAQIPILIAVPIQDLINQKCKQNIACCANSPGNASNDLVGAALPCVALGSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLC5</accession>
    <name>A0A9W9XLC5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_000203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794100.1">
        <property type="nucleotide sequence ID" value="XM_056929807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLC5"/>
    <dbReference type="GeneID" id="81620056"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051747">
        <property type="term" value="F:cytosine C-5 DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032852">
        <property type="entry name" value="ALKBH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF4">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="494"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="628"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR632852-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5495087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="669" mass="74710" checksum="4CBA2DF2F4658E49" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLK8</accession>
    <name>A0A9W9XLK8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Scramblase-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794222.1">
        <property type="nucleotide sequence ID" value="XM_056929929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLK8"/>
    <dbReference type="GeneID" id="81620178"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF9">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="59297" checksum="FAAAC5C8FFD2E5D6" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM26</accession>
    <name>A0A9W9XM26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL5m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_000504</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794401.1">
        <property type="nucleotide sequence ID" value="XM_056930108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XM26"/>
    <dbReference type="GeneID" id="81620357"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="6">
        <location>
            <begin position="251"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5495388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="355" mass="39350" checksum="B55C8542B8396FF3" modified="2023-11-08" version="1">MAVRESSRHLARSVPRAFVPCNRTPAFLGRRNASDEAPSRRLSDQLDELETASSLSATVPEDVAKSFDPVARSKGRKSQLPRSRYQFRSPKYDRGPLHPHQPPPPSDPSSRLFVPGPFSLPRAQQTYNATVASDILTLCYVHTPPGFKAPVKAPRLREWDESSPYHKNRPLRGPRGGDVLRLLRKPIKFNNIPEIERITIHSYVKGAAQENSGWLHVAGMAVQAISNVRVETSKSRASVATWSIAPGRDTVAVKAEMYGETMYHFLSKLVDVVLPRIKDWPGVKGSSGDSSGNITFGLEPEQVALFPEIEVNYDMYPPKMIPGCHITLHTTGKSDKDARLLLSAMGVPFYGKIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMK8</accession>
    <name>A0A9W9XMK8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfide:quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794745.1">
        <property type="nucleotide sequence ID" value="XM_056930452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMK8"/>
    <dbReference type="GeneID" id="81620701"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070221">
        <property type="term" value="P:sulfide oxidation, using sulfide:quinone oxidoreductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000203">
        <property type="entry name" value="Related to sulfide:quinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="42"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="452" mass="48711" checksum="F42F34A768C8949E" modified="2023-11-08" version="1">MLGRQVSSAARAAGRTAHALPRTRNYATVTESPVSTPGRAHKVVVVGGGSAGMAISHQLLQSGKFSQDDIAIVDPAEWHHYQPGWTLVGGGLKTKEELRRPLRDLADSKLKLYADSVAAFSPENNAVTLGNGDSLNYEQLIVAPGLAVNWGAIKGLPEALADSTAPVSSIYGYDSVSKVFGTIKKLEKGNAIFTQPAGVIKCAGAPQKIMWLALDHWKRAGLYDPADPAGSSIKINFATGLPVMFGVPKYNKALTALQQERGVNGLFQHDLISIDGNKATFARPDGQEQVTKTFDLLHVAPKMGAPAFVKNSVLANEAGFVDVDDATTRHKKYGNVWSAGDASSLPTSKTAAAVTSQAPVLVRNLLQTMEGKQADALYDGYTSCPLLTEYGKVLLAEFKYGGEPKETFGDWFGIDQAKPRRSFYHLKKDFFPWVYFNAMVKGNWAGPKGWIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMM3</accession>
    <name>A0A9W9XMM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal peptidase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_000406</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794303.1">
        <property type="nucleotide sequence ID" value="XM_056930010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMM3"/>
    <dbReference type="GeneID" id="81620259"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016089">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="143"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5495290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="260" mass="28140" checksum="49267DF249EBD164" modified="2023-11-08" version="1">MHSALNRLQAVFGFFTTVALVVAGAAALSVLLFPTDATTASVSLKNVQVVKGRPHYYSTKREEYAQIRFDLDADLTPLFTWNTKQLFVYVYATYSSSDKPDSTSTTRASEAIIWDSIIPAAPSPYSFDQLKEKTLSLLPASLKSGTSASSKRSAKPKSSAKSQKKEKAKKLETPGVLRLRGQRAKYQISDITGRLAGRENVTLSVGWNVQPWVGALWWAPATGAVPHTQGQLVSAESFDFPALKGAKKPVEGAQGTQASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMP1</accession>
    <name>A0A9W9XMP1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794841.1">
        <property type="nucleotide sequence ID" value="XM_056930548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMP1"/>
    <dbReference type="GeneID" id="81620797"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="369" mass="40930" checksum="18C3B5F934143F07" modified="2023-11-08" version="1">MSGAVHSDPVQLIQGYRSLPILGGYLILAGALAVNACRIIYVRYCARLKQNDWDRSHGHTQFLLFASLAGLSLGATWYYMFAFFAHSYHNWAASQPTVDLVDPQKGTLFKLELWLQNAKLFREAWETVIETRARFWWSGQIFLWTTGWSVFLGVMGDSDIQDSPRMGLHAFGPDRCHLLCAESVLRNNSCLSKATTCEGGSRMAKNVVRDPVVAWSPPVYLEAIPVAISLISTVLVPSVAHTKYFMLLLLIPHLLLFVPAILRPSRSWSRESQAQAGTEEGVLRRYVTGFKWYTAACVAIQAHSTFLVLQDNGLTMGAASLASLARHLPSVIYEHPAVSSVSWDVIMCTATAIAWIVVNGGEPRKMLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMS9</accession>
    <name>A0A9W9XMS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_000255</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Forms homooligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794152.1">
        <property type="nucleotide sequence ID" value="XM_056929859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMS9"/>
    <dbReference type="GeneID" id="81620108"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11855">
        <property type="entry name" value="SH3_Sho1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000213">
        <property type="entry name" value="High osmolarity signaling protein SHO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035522">
        <property type="entry name" value="Sho1_SH3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="232"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="185"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5495139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="291" mass="30784" checksum="8E7442488F893187" modified="2023-11-08" version="1">MAKFRASNILGDPFALATLSIAILAWLIAFISSIIADIQADYYNFNWWAISYMFCVTVGLIFTFGTDTGNVYSVAIVGYLASGLVLTSIAANNAVNAGQAAKQAAGAGFILLSMVVILWIFYFGSAPQASHRGFIDSFALNKEQPGSYRGSAPMSSAFGARPDTMATSNTPQMYTSAQLNGFETSSPVSGYPGGAPGAERNSSQPPRFGGASPANAGGGAAQEGSEVPPPTEYPYRAKAIYSYDANPEDANEISFSKHEILEVSDVSGRWWQARKSSGETGIAPSNYLILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJN7</accession>
    <name>A0A9X0BJN7_9EURO</name>
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        <recommendedName>
            <fullName evidence="1">Vacuolar ATPase assembly protein VMA22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_009141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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        </lineage>
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    <reference evidence="3" key="1">
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            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="81628986"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Vma12-Vma22 assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:unfolded protein binding"/>
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        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040357">
        <property type="entry name" value="Vma22/CCDC115"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21730">
        <property type="entry name" value="Vma22_CCDC115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056938159.1"/>
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    <dbReference type="GeneID" id="81628409"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="KAJ5471995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="111" mass="12272" checksum="F4A60548932F5F24" modified="2023-11-08" version="1">MAEKSEVITLDAAPQDDERLRKMVQEKVKKNVALDKDWTVGGNLESIDHSIPALLLRKDGAWGAVRVDTSPVLNEVSGPGMDPGIALILIKPGETCRFYQSPSVRYFRYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BLV3</accession>
    <name>A0A9X0BLV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="3" type="ORF">N7539_008669</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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            </authorList>
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    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <end position="379"/>
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            <begin position="9"/>
            <end position="29"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5472100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="390" mass="43469" checksum="9503CB964CEA6880" modified="2023-11-08" version="1">MPSASYRLESFRPWKPSQEKEQPLRDRLGICRYPSPVSISATPSPSNLRNSISESQEIYAPRPERHPLPARPPVEVCLNGGLQSNTQHESEGLAPTSPINPGPETFDIDNSLFPDDPPNSGDVDRTMTFEQIAPDSELQFLGFDSNGRQLAFPPSQQAQLGFLESPISLESPTIDPAILDNNHTRDFEQTQQTATTPIAPTISRQIPVEHSRSPARGAHCHSKQQDSVRPVKAGRRPAKISKVSVVIDNRPKNRASRSGLGLGRKNVSLPTLRAQFSAPPVEERVQFLSWLFESALSHCVHLPHGSDRSQHANRDAELVDRPRTPCSRKGLSWSDEEADLLVKLREEEHLAWSEVTERFGEKFPGRSQGSLQVYWSTRLGKRRSSPVENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNL5</accession>
    <name>A0A9X0BNL5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">N7539_007178</name>
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        </lineage>
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            <authorList>
                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787578.1">
        <property type="nucleotide sequence ID" value="XM_056936779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNL5"/>
    <dbReference type="GeneID" id="81627028"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="481" mass="52502" checksum="3B5C98891EC9B6A4" modified="2023-11-08" version="1">MRFLDGTGQPNSSSVSLQSSTVRWQQSTSRLWRRSVSSWFGSKDLFHQATVETWQRSSGSRDNSKVAVDQQHKNPVVSSETNNQSSMHLAKEDHAITPREASRTRPPSEQPVKSGKESATESKTMSTQTHGTSQDKKSIPDRPKASQAGRTNSSLSSPLTDLSTVSSMSSPSVSSKTFPRGTGIDAKAFSPLAVDLSVEKRRPDEQVRDLLNYTDHVLAQAQTTRQLRDTKSTLLGQVEHNWIHSTITDAVDSAQELAEILEPCKQDMAKRKGKGKISSANRKQWKVRNRERAEERQARLIRYHCRLDQVYQHLTKLKLPQVIPITDVVLPDAAEMPAVAKVESTVWELPSEPQSLTTAEISGMSEMPEMPPASPAQPPIPTGAVEMPADFGATSLVAELPDVDQECATTTLSAASPSPDKVTLSSGRSSTAPRIPRKALPIIAELPCGVADVSMRNVQPLPEISIADAHNCTSAMRSSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNZ2</accession>
    <name>A0A9X0BNZ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">(S)-ureidoglycine aminohydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787968.1">
        <property type="nucleotide sequence ID" value="XM_056937169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNZ2"/>
    <dbReference type="GeneID" id="81627418"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071522">
        <property type="term" value="F:ureidoglycine aminohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02212">
        <property type="entry name" value="cupin_UGlyAH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02211">
        <property type="entry name" value="cupin_UGlyAH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017627">
        <property type="entry name" value="UGHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044697">
        <property type="entry name" value="UGlyAH_cupin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008579">
        <property type="entry name" value="UGlyAH_Cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044704">
        <property type="entry name" value="UGlyAH_cupin_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040771">
        <property type="entry name" value="AAH_UGLYAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008373">
        <property type="entry name" value="PRK11171.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008376">
        <property type="entry name" value="PRK11171.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03214">
        <property type="entry name" value="ura-cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34571">
        <property type="entry name" value="(S)-UREIDOGLYCINE AMINOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34571:SF1">
        <property type="entry name" value="(S)-UREIDOGLYCINE AMINOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05899">
        <property type="entry name" value="Cupin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="(S)-ureidoglycine aminohydrolase cupin" evidence="1">
        <location>
            <begin position="65"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-2" evidence="2">
        <location>
            <begin position="196"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5477424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31279" checksum="7FC71F9E09E77275" modified="2023-11-08" version="1">MGSARTYYAPTGGLPPQTQILTDRAMFTEAYAVIPKGTFSDIVTSFLPFWDKTRLWVIARPLSGFAETFSQYIMEVQAGGGSERAELDEGAEGVIFVVEGQVTITLDGKPHQLTEGGYAYLPAKSGWSLCNKGSSTARFHWVRKAYEYVEGLDKPDPLFLNEKDIMPTEMPGTNGAWATTRFVDPSDMRHDMHCTIVTFEPGGVIPFAETHVMEHGLYVLEGKAVYRLNQDWVEVEAGDFMWLRAFCPQACYAGGPGKFRYLLYKDVNRHMKLSHHSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BS20</accession>
    <name>A0A9X0BS20_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH-response regulator protein palF/RIM8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_006559</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family. PalF/RIM8 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788095.1">
        <property type="nucleotide sequence ID" value="XM_056936160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BS20"/>
    <dbReference type="GeneID" id="81626409"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF161">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALF_RIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="299"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="629"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="706"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="721"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="767"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5480665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="777" mass="83633" checksum="ECED33C76FA8E355" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSE7</accession>
    <name>A0A9X0BSE7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Histidinol-phosphatase</fullName>
            <shortName evidence="8">HolPase</shortName>
            <ecNumber evidence="3 8">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_006772</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-histidinol phosphate + H2O = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="3 8"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788308.1">
        <property type="nucleotide sequence ID" value="XM_056936373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSE7"/>
    <dbReference type="GeneID" id="81626622"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="HISTIDINOL PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039:SF0">
        <property type="entry name" value="HISTIDINOL-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="9">
        <location>
            <begin position="5"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5480878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="290" mass="33053" checksum="E4AE955E7DF77379" modified="2023-11-08" version="1">MPFSHHSHSGQFCPGHAKDSLEDVIQTAIAKKMQVFCLTEHMPREAIDFYPEEIEAGETEAHHLANEAAYFTEALRLRTKYAPQISIVIGFECDWIRPSSQTLINRSLSRLPFEFFIGSVHHMHTIPIDYDRDMYLRAREIAGGSDQRLFEDYFDAQLEMLRALKPPVVGHLDLIRLKSDDAERSFKAWPGVWSRILRNLDFVVEYGGELLARGGRFCLSDDSHGIDQVSLNFHLVLGFLNEVGVKELHYLSLVGEEGGDLTSAPDDRFPRTRIAAVSMEEVKQMAFWQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSL5</accession>
    <name>A0A9X0BSL5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_006786</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chitin synthase family. Class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788322.1">
        <property type="nucleotide sequence ID" value="XM_056936387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSL5"/>
    <dbReference type="GeneID" id="81626636"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="709"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="748"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="779"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="823"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="951"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="983"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="12">
        <location>
            <begin position="288"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="80"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1041"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1041"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5480892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1087" mass="120277" checksum="CD8FAEE0074CCD93" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUI7</accession>
    <name>A0A9X0BUI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_005236</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790032.1">
        <property type="nucleotide sequence ID" value="XM_056934838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUI7"/>
    <dbReference type="GeneID" id="81625087"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000026">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="242"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5485248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="442" mass="49291" checksum="3E585E69C5025851" modified="2023-11-08" version="1">MASTCSTPRSPSLVSNPFKSTSPKSSAWLSLLKRSGQHLRRSSKDNGHSTGTRSLSTSPTDKASPPQHVESAPQSPQQGRSMSISPPRTLPVVTDPPVSILKKSNAFDLDSIIWDDSVRDRQNMKSSVDLDDAIARLLAAGSSKPSKSFCLTNVEIAGICSSVRNILLSQPILLEVNAPIQIVGDLHGQFPDLLRLFDTCGYPPTTNYLFLGDYVDRGKQSLETMMMLLCFKLKYPENFFILRGNHECANITRIYGFHDECKRRCNIKVWKTFTDVFNCLPIAAIVAEKIFCVHGGLSPNLTDMDDIRKISRPVEVPEYGLLNDLLWSDPANIRDWGPNDDRGVSWCFGKQPIVNFLKHHNLDLVCRSHMVVEGGYEFFGNKSLVTIFSAPNYCGEFDNCGASMSVSADLMCNFNLLRPFDQKKADRQMRKARESTKTEKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUP4</accession>
    <name>A0A9X0BUP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4396 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_005105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789901.1">
        <property type="nucleotide sequence ID" value="XM_056934707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUP4"/>
    <dbReference type="GeneID" id="81624956"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025509">
        <property type="entry name" value="DUF4396"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14342">
        <property type="entry name" value="DUF4396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4396" evidence="3">
        <location>
            <begin position="79"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5485117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="218" mass="24006" checksum="83F08769BA898023" modified="2023-11-08" version="1">MFFLTTTSRLSPLRSLAWPTSLGRRHFTSSLPTRICQSNPQSRSPCSSTSDQQATSTSSSASTRSVPIFSRAFWSCRSTWRRAGINTLRCLVGCTIGDFSALWTLQSYYPELGMNTIMLASMGCGITTSIILETVLLRRGADQLSWSRAVRTAMGMSMVSMVAMEIAENAVDYHLTGGVIAFEDPKFWAAAVLSIGAGYLAPLPYNYLRLRRYGKACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUR3</accession>
    <name>A0A9X0BUR3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_005165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789961.1">
        <property type="nucleotide sequence ID" value="XM_056934767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUR3"/>
    <dbReference type="GeneID" id="81625016"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5485177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="150" mass="15810" checksum="709A6F81ED399C8E" modified="2023-11-08" version="1">MAPKKTTPAAKENVSLGPLAGDGKLVFGVARIFASFNDTFVHVTDLSGRETIVRVTGGMKVKADRDESSPYAAMLAAQDVAVRCKELGINALHIKIRATGGNGTKTPGPGAQSALRALARAGMRIGRIEDVTPTPSDSTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUU4</accession>
    <name>A0A9X0BUU4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Translocator protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_005566</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790362.1">
        <property type="nucleotide sequence ID" value="XM_056935168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUU4"/>
    <dbReference type="GeneID" id="81625417"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033013">
        <property type="term" value="P:tetrapyrrole metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.100:FF:000001">
        <property type="entry name" value="translocator protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="entry name" value="TspO/MBR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057:SF0">
        <property type="entry name" value="TRANSLOCATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005859">
        <property type="entry name" value="PBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5485578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="20106" checksum="DA5ED7E5FC040B4F" modified="2023-11-08" version="1">MPWSFALPQAIFASPLLAVATPIGVGMTSALLTSRSNTKDTYKQLRQPPFSPPAWLFGPAWTVLYGLMGYASHHSTAVASHSILPGLREANQTAQVLYTSQLALNFLWTPLFFGLGRPASALADMALLIGNVSLLMANWWDSDRTAFWLMTPYLGWLSYAFYLNAGVGYLNNWTLYPKSHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUV7</accession>
    <name>A0A9X0BUV7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein g.t1.c1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GET1</name>
        <name evidence="10" type="ORF">N7539_005224</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the WRB/GET1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUV7"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000006">
        <property type="entry name" value="Protein GET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03113">
        <property type="entry name" value="Get1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027538">
        <property type="entry name" value="Get1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Lumenal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="4"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="9">
        <location>
            <begin position="173"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5485236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="208" mass="23652" checksum="89EB602B11A14B29" modified="2023-11-08" version="1">MLSLVLTILFVHIAIYLVNTIGAATIDALVWHLYLKLPTSTSRNARAANLKKREVVQLKREMNSTSSQDEFAKWAKLRRRHDKSVEEYEALNKKISSQKTSFDWSVKSARWLSTNGLKLFLQFWYSKTPVFALPPGWFPYYVEWILSFPRAPLGSVSVQVWNNVCATAVVFFGEFIGGVLVRIMKATSTTTTKEKVSVAVDGENKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUZ6</accession>
    <name>A0A9X0BUZ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2415 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789914.1">
        <property type="nucleotide sequence ID" value="XM_056934720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUZ6"/>
    <dbReference type="GeneID" id="81624969"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019417">
        <property type="entry name" value="DUF2415"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF9">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10313">
        <property type="entry name" value="DUF2415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2415" evidence="2">
        <location>
            <begin position="334"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5485130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="763" mass="85132" checksum="FF1F07F192E1D804" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYC0</accession>
    <name>A0A9X0BYC0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL28m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_004591</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791734.1">
        <property type="nucleotide sequence ID" value="XM_056934193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYC0"/>
    <dbReference type="GeneID" id="81624442"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.40:FF:000003">
        <property type="entry name" value="54S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="entry name" value="Ribosomal protein L28/L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribosomal_bL28_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5489701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="227" mass="25801" checksum="1973B7C2EA71964C" modified="2023-11-08" version="1">MAGLQLRSAMATPFSLTAAFRALSVSTPKRAFTTTSAAQSAPKLPADVPAYPYGPRQWYKQADTGLYGGSMIRFGNKISKGRNEGKTRRSWKPNVRRKKMWSEALQQHLFIKVTRRALRTIISEGGLDKYLLSDRPARLKELGVFGWHLRYQVMQSPAIKEQFRQQREKMGLPEPMTFEEWMKAKEEEIEATVEERLNIKPLTKPRPKGQADPQNDARKIAAAEALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYG0</accession>
    <name>A0A9X0BYG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791542.1">
        <property type="nucleotide sequence ID" value="XM_056934001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYG0"/>
    <dbReference type="GeneID" id="81624250"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="353" mass="37410" checksum="7CBE6C44BA4269BF" modified="2023-11-08" version="1">MTQTMASHRRSASSTHLSNKLLKTAPTSRPGVHRRGTSAIALSISKLGSGPSARSQSRATATLDDDSDMAASFLNFCCRRKDSAKPLSASLSPTASFSTNYHHHHHHHHHSSSPSSNTHLTPVTMPPSPPTSPSLSPRTIVAPMTPTRVLSSTSASVPSIRIPATFHEAKSDLDPTEWKPVLGSRTTSAASMTSTTRSLATSDAWGYLSHFHGGASAMLTRRTHRSTASLSGLEGVPTPSLTHAPSVASSVSSAASSDGHEHGHEHEYELEQKGLHTRIRRPLPPRHNPYFSLSHAAENGISLVVPHVAAVTVQDVESDSGSIFPASSAVWEDHASGKTGAPILMRTTPTNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYG5</accession>
    <name>A0A9X0BYG5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_004067</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791210.1">
        <property type="nucleotide sequence ID" value="XM_056933669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYG5"/>
    <dbReference type="GeneID" id="81623918"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000071">
        <property type="entry name" value="Cell surface metalloreductase (FreA), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF26">
        <property type="entry name" value="FAD-BINDING 8 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="249"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5489177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="526" mass="59797" checksum="FFB3C2AC0F58D7B7" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYJ6</accession>
    <name>A0A9X0BYJ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_004368</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791511.1">
        <property type="nucleotide sequence ID" value="XM_056933970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYJ6"/>
    <dbReference type="GeneID" id="81624219"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF152">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="51"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5489478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="482" mass="52480" checksum="96E873DCBD442D3F" modified="2023-11-08" version="1">MARASDPSPQTAPTQVQSTQLSVATDDEIDSKPHPHLKAGHHLPLWRKCLILFVVSWMTLLVTFSSTSLLTAIPEIANDLSTTREILNIVNAGVLIAMGFSSFIWGPISQIVGRRHAYNSATLVLCACSAGAAVSTNLHSFVAMRVLCGLTGTFFMVAGQTIIADIFRPTVRGTAVGLMMAGSVSGPAIGPCVGGVIVTFSQWRVIYWLQFGMTLFGLILSLIIIPDITRHRSQSVEKRPISLFYVVRLFNPLHVFRPFIYPNVVLCHFTCGLLATFQYGFLTSARSIFNPRFHLQTPLVSGLFYLSPGLGFLIGSIVGGKLSDRAVKQWIKKRNGTRLPQDRLNSGLVNLFVVLPSSTLIYAWTLQQEVGGMAVPIISAFAAGVGLLGTFNGLNTYSAEVIPQLRFQVISGKYVMQYAFAAAATASVEPSIGCIGVGWTFTIYVFLALLGGLCVCAIIRWGFDMQRWVERTFDVDEKPSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ06</accession>
    <name>A0A9X0BZ06_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_004682</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791825.1">
        <property type="nucleotide sequence ID" value="XM_056934284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ06"/>
    <dbReference type="GeneID" id="81624533"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="236"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5489792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="399" mass="44646" checksum="BFF3671A38F7FAA9" modified="2023-11-08" version="1">MSFPQDETLEAQIAALTQSVRANRDSLDDATRYSALKAARSLVEALGSPPETVIHDVVMQPALLMSLRMGVQLEAFRAICDGQDRGATTAQIAKRSGASVFVVDQILRVLSASGYVLETDVQTYKPSSLTMLMADPNFEATTRACFDIGNFSTTYAPEYFQKNNNQFPTSAIDTPFQLAKNTRLDYFQWLGQNPSLAKDFQQWMTLKQRSTPNWVDWFDVQTAILDGLRNRPDEVLLVDVGAGEGHYIHAFNEKFPAAPGRRVLQDLPQVVSDLKDAPKDTELMAHDFFTPQPVKGARAYYMHWILHDWRDEQASDILRNIVAAMEPGYSRLIINDQIIPDRNCDYATACISIMMMVQVGAFERTEKQWRALLTSVGLKDLSFHQPPAGGEGIIVATKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ53</accession>
    <name>A0A9X0BZ53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydantoin racemase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HyuE racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791956.1">
        <property type="nucleotide sequence ID" value="XM_056931997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ53"/>
    <dbReference type="GeneID" id="81622246"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052186">
        <property type="entry name" value="Hydantoin_racemase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047:SF5">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5490827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="30192" checksum="223556D87ACA6944" modified="2023-11-08" version="1">MSPERGDVPFRIMVVNPNISVEMTDALRPIIDGLKFGDVEWTFYTSHREDSEEPIESINGPEDSAKTAWACRNVTQHIPQHDAFLVACYSAHPLVGMLRKAIAEYEAEHSGQRHRFVTGIFEASVMTSLSLISAFSLTSVRYAREQVEDSFGIVTTGSAWKPDLTCAVAEMLVGKDADPPACFAGVATTGLSAIELHHTDPQEVRRRISKATADLLRNSKTFVAAVCLGCAGMVGMDEAVREGCITAYGKQKGMRVRIIDGVLAGARQLADHCRSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ85</accession>
    <name>A0A9X0BZ85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792378.1">
        <property type="nucleotide sequence ID" value="XM_056932419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ85"/>
    <dbReference type="GeneID" id="81622668"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF23">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="50"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5491249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="335" mass="38168" checksum="D0337310371D5BD6" modified="2023-11-08" version="1">MKKGADNAGISGNAPRSSEASCRRRWTKHTGVLHRWEQRYWLLSHVSSQQACTNAEAEVPAPGKDFARLEQEAVDSWSEKLRPIKIRAGGVRDAMIGAFWSGIYRTMLSPQNMTGENPVWKSDEPYFDSFYCIWDQFRAQLPLLSLIDPKTQTNLICSLLHTYKTEGWLPDCRMSLCKDWNQGSSNADVVLTDVFVKNLTGIDWELAYNDAENEPLEWSYEGRGGLQSWKRLNYIPYLDFDYPGFGTNSRSISRTVEYAYNDYSLAVVGKGLGKSENTKYLSRANNWRNSFKADQKSVSENGTDTGFTGIFQPKYVNGTWGFQDPIARHSSRRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ96</accession>
    <name>A0A9X0BZ96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_003127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CKS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792689.1">
        <property type="nucleotide sequence ID" value="XM_056932730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ96"/>
    <dbReference type="GeneID" id="81622979"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5491560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="132" mass="15633" checksum="50E9A480B26D72EB" modified="2023-11-08" version="1">MEIDMSRRNKKPRLLLESERERLDEFIDSIHYSARYVGNHARDLSVRSSLICLSSADAIANLDRYSDDKFEYRHVQLPKNMLKKIPADYFDSAKGTLKLLWEEEWRALGITQSLGWEHYEVHEPEPHILLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ99</accession>
    <name>A0A9X0BZ99_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_002861</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792423.1">
        <property type="nucleotide sequence ID" value="XM_056932464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ99"/>
    <dbReference type="GeneID" id="81622713"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17947">
        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="325"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="526"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="720"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="675"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="754"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="797"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5491294.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="806" mass="89502" checksum="F1EC102377F0899E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9X0BZT9_9EURO</name>
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        <submittedName>
            <fullName evidence="3">Mutanase</fullName>
        </submittedName>
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    </gene>
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        <name type="scientific">Penicillium diatomitis</name>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
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            <end position="96"/>
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            <begin position="38"/>
            <end position="63"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5492773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="96" mass="10533" checksum="32DC18A68A51E5D7" modified="2023-11-08" version="1">MFKALSALRSFCLILDSSWFCEEAEKVPVFSEPLAGLEIDHRRRDRTSQQQGEDMGLSSSSPYPSVAMAAEIVPSASRPMTSQMAMNHRVDAGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">N7539_001387</name>
    </gene>
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        <name type="scientific">Penicillium diatomitis</name>
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                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492641.1"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <location>
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            <end position="500"/>
        </location>
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        <location>
            <begin position="542"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
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            <dbReference type="EMBL" id="KAJ5492641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="558" mass="62394" checksum="86601B04080E6C0D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C011</accession>
    <name>A0A9X0C011_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Penicillium</taxon>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5493057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="260" mass="29625" checksum="2460C9B19FD15E61" modified="2023-11-08" version="1">MNRSYLSSTDGAGDGIDNPRGESSFFQITDSIQNYHREQATGARLLAWILDPQLACPISISAYSWGHIQNTEWDMNEQPDELPSVYSGSNFLPVDLPGMQRSRTAANPYQSLAIFKYPPSQPFNSCRWIGRIGKGVIFLEDISRPEKLGYPFMSEMTKAIYERHFELGTLRYVVISHVANSVTRGFIIGVLQHSNNQNPQVWEADTPEFQILLGTPLGKVIAYLMLNAFPRGSRRIARIALWFDDKSWPHLRFDIVRIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C265</accession>
    <name>A0A9X0C265_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAD superfamily hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_000277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794174.1">
        <property type="nucleotide sequence ID" value="XM_056929881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C265"/>
    <dbReference type="GeneID" id="81620130"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07505">
        <property type="entry name" value="HAD_BPGM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044999">
        <property type="entry name" value="CbbY-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42896:SF2">
        <property type="entry name" value="CBBY-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42896">
        <property type="entry name" value="XYLULOSE-1,5-BISPHOSPHATE (XUBP) PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5495161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27888" checksum="D817E4F497685729" modified="2023-11-08" version="1">MPKITEIFFDCDNTLVLSEVLAFEACADLANEILESRGISDRYTGEQLIKDFVGQNFRGMMISLQAKYKFEMEQDELEMYVKKEEDKVIAKLEAKANPCVGANEQLEKLAAEKKYHMAVVSSSALRRVVASIKKVGQDKYFDKDMVFSAATSLEKPTSKPDPAIYLHALKVCGKTASETVTVEDSKSGALSAIRAGIPTIGYVGSYPPEEQSEMATRLKDLGVKIIMKDWSEFPKCLEFLENGPIETQSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2D0</accession>
    <name>A0A9X0C2D0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794369.1">
        <property type="nucleotide sequence ID" value="XM_056930076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2D0"/>
    <dbReference type="GeneID" id="81620325"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="349" mass="38490" checksum="56A6913A451B332F" modified="2023-11-08" version="1">MVLLTASTVSAIVSMGVVCIFTTLLFVSGYVLQQNSVKNIQHALRKPPDMPAYQGYGASVGNPLQKRGISASNLNPAAEQGVIGDSGADSSEARNNYAYLQLLSKPDPSDICSAILFFKRLATNGSVIADRLFMYPEVWDRMLGKNLGEASTLALALLRAASIKYGIWLLPIDISPVLRAGYTMSDTKLLRLGQIQFMQYDSVLYLQSPGLITDVDRLDQVLLSHSLPLLHDWNRPQSYDNEAWEPSSLRPDRDDTLPPVYLLTVNNVDGGRVQTRTHVPKPDVPGFSNLVVSPADFERSAEVPGYVYFENDEEGRVRWAGNSLFGAWRSQQHEVCGGLDFDGDGIYEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2P5</accession>
    <name>A0A9X0C2P5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase 9.5 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794383.1">
        <property type="nucleotide sequence ID" value="XM_056930090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2P5"/>
    <dbReference type="GeneID" id="81620339"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8376" checksum="3D04FCBC01D70921" modified="2023-11-08" version="1">MSTPQFWSTPLRYLRWASHEKPAIFYSLIIGSMGPVALVGLPPLRRALGDVDPEPIPMTYPIPQGPRVVPKGYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C374</accession>
    <name>A0A9X0C374_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_000950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794847.1">
        <property type="nucleotide sequence ID" value="XM_056930554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C374"/>
    <dbReference type="GeneID" id="81620803"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5495834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="221" mass="24647" checksum="BAC731212D013A68" modified="2023-11-08" version="1">MDQRSMTTLPHHASAQTHTLSVDFAWSQFKSLVTDASDESKTPLYIVSCNVLTSKLTFKTAPDDKIMGTSSVHAISISPDYELHGVKGTLQAQHRLRTIYSHTSTVFSDSGAPVKMTWTSQSGFKNWDFICVDEMQQPVAKFSASMWNPKKWATIEILGPKAHDVRARDEIVLVGFTLYWCMVVRINNPLNLLGSVFMSTEKTSEEEQIEKPTRVGAVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL43</accession>
    <name>A0A9W9WL43_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-tRNA hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_009446</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785763.1">
        <property type="nucleotide sequence ID" value="XM_056939041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL43"/>
    <dbReference type="GeneID" id="81629291"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="entry name" value="Peptidyl-tRNA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="Peptidyl-tRNA hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5466717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="26536" checksum="4A11B34E87BBD10C" modified="2023-11-08" version="1">MTLTRPPQRLLYIASIGNPAPYRKTRHSAGHILLDSITPLLRARLGPSASHLYTTFYSPSLMNISGPKVVSTMQKWLAGRDNSIAPDALPPAVLLSGLDRQVPGSPASSSGRRGFPATLVILHDELEAPLGKIRVKRGGPESASLRGHRGLISVLETLRGKGLFPGSGAGSVKTNVKTKTRLGKREGGLPRELEVLRVGIGIGRPAGREKDAVANYVLKEMEGRELDAVSRAAESVVDVLEEEMCRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLB6</accession>
    <name>A0A9W9WLB6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_009176</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786148.1">
        <property type="nucleotide sequence ID" value="XM_056938771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLB6"/>
    <dbReference type="GeneID" id="81629021"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01414">
        <property type="entry name" value="SAICAR_synt_Sc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000392">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000015">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010568">
        <property type="entry name" value="PRK13961.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="10">
        <location>
            <begin position="17"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5469558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="300" mass="33439" checksum="EF0FF2A200D43D06" modified="2023-11-08" version="1">MSEAITKIDLQGALPLVASGKVRDLYEVDDKTLLFVASDRISAYDVIMENGVPNKGVLLTLCTKTWFEILTKAIPSLRTHFITLDLPPQIPESLRPKLQKRSMQVRKLRILPIEAIVRGYITGSAWKEYQKSGTVHGIKVAPGLQESEAFPDGPIYTPSTKAELGEHDENIHPDEATKIVGEPYASTVASLAVQLYKAAHAYALERGVIIADTKFEFGVDEETNEVVLADEVLTPDSSRFWPKDSYKIGQGQASFDKQYLRDWLVSEGLKGKEGVRMSEEVVQKTAEKYKEAWEKITGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLG5</accession>
    <name>A0A9W9WLG5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_009313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786285.1">
        <property type="nucleotide sequence ID" value="XM_056938908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLG5"/>
    <dbReference type="GeneID" id="81629158"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="2">
        <location>
            <begin position="227"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5469695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="439" mass="47783" checksum="F7BEF9A6526FF970" modified="2023-11-08" version="1">MKPLRHTREKRPGKLSIADQTSASTKRINVNWVIMTATSVLVAALALLGSSGAEASNLPAQAQLINQKAFNVLNNTQPPAVFNADNIFVPPGLTEQALTNRPFHVYDEEFMKIIGSHPTLTRIAHSPKNPLYHEAVVWSKKTDEVFFVQNAGAKTSGTGLNKSAIIEKISLSEAARYYNQSDAAGRVNVVTVPSSPMVINPNGATNYRGEIVFTGEGQGNSSPPALWVMNPQSPYNTTVLLNNFFGRQFNSLNDVAIHPKNKDVYFTDTIYGYVQDFRPSPGLRDQVYRLNPSTGAVTVVADNFGHPNGLTFSPDGKHAYVTDTGINYGFYGMNFTQPASIYRFDVKEDGTLENRKTFAFVSPGAPDGIHCDSKGNVYAGCGDGVQVWNPSAKLIGKIFLGSTTANFQFVGHGRMVICAETDLYYATVAADGNYVESEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLU9</accession>
    <name>A0A9W9WLU9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_009180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MATALPHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786152.1">
        <property type="nucleotide sequence ID" value="XM_056938775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLU9"/>
    <dbReference type="GeneID" id="81629025"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045895">
        <property type="term" value="P:positive regulation of mating-type specific transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006856">
        <property type="entry name" value="MATalpha_HMGbox"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04769">
        <property type="entry name" value="MATalpha_HMGbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51325">
        <property type="entry name" value="ALPHA_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Alpha box" evidence="6">
        <location>
            <begin position="147"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5469562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="294" mass="33804" checksum="30513B53C1488C67" modified="2023-11-08" version="1">MAETEALVVTTFPTDPSPPHGHHTLAEIDLKLLVFMNHSHESDAFTLWHFYPKGSSAHAFAVLAMTNFPDEDLAIIEERPIRDGLRYTIINDVMRQYDSLTNLLVDPTPPVVPEFDDLGQNWAFQEYVNNLNVNHADLQPWELDFNWHLRPVNSFMAFRAFCGPALFNRPQTMRSAYVSRFWIVSPHRPQFELIAQAFNYLRDTHGMQTNLRFFVFFVATRLFRLPVPSLYIMMCGWNFWIRDARNLWPANFSHCPTCPSVTGQEVANFARMLRLSPTVPGAEPMAANTNTLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLX1</accession>
    <name>A0A9W9WLX1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_009166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786138.1">
        <property type="nucleotide sequence ID" value="XM_056938761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLX1"/>
    <dbReference type="GeneID" id="81629011"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205">
        <property type="entry name" value="NB-ARC AND TPR DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205:SF1">
        <property type="entry name" value="ZU5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="3">
        <location>
            <begin position="76"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="536"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5469548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="762" mass="86447" checksum="EF5BAB110E461867" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQK8</accession>
    <name>A0A9W9WQK8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786369.1">
        <property type="nucleotide sequence ID" value="XM_056938361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQK8"/>
    <dbReference type="GeneID" id="81628611"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF55">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="81"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="315" mass="36021" checksum="97596F491F6DD125" modified="2023-11-08" version="1">MLESFIPAILRPDFTWPRVMPSTISEKTPALPRVSSRNVRVAWGVVHKSLYYFSQWYCSWFGITFNANIVQLPFGLVMKWTDRTSIEEVVSMQMAAAAGIPVPRVLNYGEHLKAPFNRKISILMTRLPGVSLENSDDELQVDLEEPWLEELNKCVRSMRSWLPPNHHSICSPTGTPLRSPRVPGHVMGPFTDHAQLLEYLISPASPHGFKTMVEYEDTLARAEKLKQRDYRITFTHGDFKAHNILIGDDGHLSGFLDWESAGWYPEYWEYTTAMRFGKGSWWFQVASWMGGDRYLGELASDIALNLLTVDSYIAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WRA8</accession>
    <name>A0A9W9WRA8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786622.1">
        <property type="nucleotide sequence ID" value="XM_056938240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WRA8"/>
    <dbReference type="GeneID" id="81628490"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038903">
        <property type="entry name" value="Allergen_Asp_f_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25312">
        <property type="entry name" value="Allergen_Asp_f_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040804378" evidence="1">
        <location>
            <begin position="20"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5472076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="259" mass="28091" checksum="545F90873647C1AF" modified="2023-11-08" version="1">MLPHLWVLAWSSLQSFCRGYELSNAIDPTPLMFDSNPAQMGIPLFALKPLKRPTSQVKEVQHARNVGDPYGSNIIEVSAEAANLYKYILRFEAPSISQSWTVAIWNNFAPDGRLGGWRGNACRTFTLERGQFRYIAFDDDSQGRWAAAPGLSVSVDGDGRYTATWGEFNFGSKINFGRSAFVVSTIATEMMGLEVQDMRICGAHSDTCSSVSARGAAVHNAYTSTTVSNGTRGGTILPGPVRLAAIIGSAGFPLPENRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WRB0</accession>
    <name>A0A9W9WRB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786434.1">
        <property type="nucleotide sequence ID" value="XM_056938426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WRB0"/>
    <dbReference type="GeneID" id="81628676"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="355"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="608" mass="68964" checksum="2658F17F8AFB3D68" modified="2023-11-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WT44</accession>
    <name>A0A9W9WT44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786784.1">
        <property type="nucleotide sequence ID" value="XM_056937692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WT44"/>
    <dbReference type="GeneID" id="81627942"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="309" mass="34524" checksum="32598F1F16F29A2C" modified="2023-11-08" version="1">MTDRQRPIKTRFLVLSDTHGLEKLAQDTSKHTIDVVIHCGDLTTESKLEEFKASIRLLNTINAPLKIAIAGNHDFTMDITAFRRKVADAKPPLNPTLVKQTYGYEGEARKLFDRQIGITFLDEGTHEFRLNNGAMLKVYASPYTLSLGDWGFQYHPDQGHDFAIPNVDVAITHGPLKGVMDMTYSAERAGCPFLFEAIARARPLMHCFGQIHEGWGAKLITWRQKRSAKPSHLTDIDNERSTTIARLSSERKKLVQSPAGAFFTSHCHSDLNPLKRGLQTLFVNAAIEGENSLPIQPAWIVDLDLSSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTB0</accession>
    <name>A0A9W9WTB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_008155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786847.1">
        <property type="nucleotide sequence ID" value="XM_056937755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTB0"/>
    <dbReference type="GeneID" id="81628005"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000123">
        <property type="entry name" value="Protein phosphatase 2C homolog 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13672">
        <property type="entry name" value="PP2C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="118"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5475089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="448" mass="47801" checksum="BB310F743DA2845E" modified="2023-11-08" version="1">MISPSVPSRVCSSTCNLQQLSGLFRQGVCFSSRDTLSFSVLGHSLPCSASKPRKSALHTTSSRSFHSSPGRFSNPSSSSARISYKVAVSSTGKGRRFHPLKNVYHFDPAKSDMIGVSKDPSPSVRKRNRPDSGEDAFFVSRIGSKVSGHPDTDGAVAFAVADGVGGWTESRVDPADFSHGLCGYMAQSALTWDSPADRLRPKQLLQAGYDQVVKDPTIKAGGSTASVGVGLTDGRVELANLGDSGSVLLRLAAVHHYSVPQTHGFNTPYQLSVIPPKMRAQASVFGGSFLEDTPQDAAVTNVQMQHGDVLILATDGVFDNLNNQDILKIVTTRMVMTGAWTATEDSGVKISREIASLTVPGGLASAFPPPKSADKEHETLESVYTLQSLLAASIAGEAKAASMDFRRDGPFAKEAQRYYPGDYYRGGKVDDICALVMIAVDENQVAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTE7</accession>
    <name>A0A9W9WTE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786794.1">
        <property type="nucleotide sequence ID" value="XM_056937702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTE7"/>
    <dbReference type="GeneID" id="81627952"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="688" mass="75327" checksum="D3AAE7B957A6FA9D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTT0</accession>
    <name>A0A9W9WTT0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycoside hydrolase 131 catalytic N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_008440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787132.1">
        <property type="nucleotide sequence ID" value="XM_056938040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTT0"/>
    <dbReference type="GeneID" id="81628290"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041524">
        <property type="entry name" value="GH131_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612">
        <property type="entry name" value="GH131_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612:SF6">
        <property type="entry name" value="GLYCOSIDE HYDROLASE 131 CATALYTIC N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18271">
        <property type="entry name" value="GH131_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040874655" description="Glycoside hydrolase 131 catalytic N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 131 catalytic N-terminal" evidence="3">
        <location>
            <begin position="20"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5475374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="394" mass="41824" checksum="571C5CE2A2C85011" modified="2023-11-08" version="1">MNKYLTLFASLPIAVQCGEVVWSGLFDSSASVADFDKWSFSNPVGAWQWYIHGNAKTSTYLGLSKDFKNPADTSDAQGVRITIDGTAFWEGQDMERSELIPQTSAQLGSGRLFYHFSVKTDTTNAPNPKFEHQLAFFESHFTELKYGRLSGDSATEDNNLRWMVGGQTKWSTDLEASQWYNFAYDIDFDGQTVGLWASNGSAPLTEVVTGVKASTSTNSADWHVGQLRLPNGGTDAQAEDWFWSGVYIEKGPITTSIAGPSAGQGQGESAAAQPQSSAPSTSQVATSQAASASPASSSTMTVEQASTSVSTSASTTSPAGKQAAATSQTSTPVIQQLSTPSAQIPSQTPAHTPEPTPVPAATPSAGGDGDDYDDDDEECEDEDGEDSGDYEEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU24</accession>
    <name>A0A9W9WU24_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_007811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787277.1">
        <property type="nucleotide sequence ID" value="XM_056937412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WU24"/>
    <dbReference type="GeneID" id="81627661"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF63">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="71"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5475524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="427" mass="47849" checksum="3C512FFBDF5C9CAF" modified="2023-11-08" version="1">MTISERAQHASSEMASRIQWEVMVDTYSATNPNGYLNVGVAENALMHPELQQYLKQKLDLPVEYLTYNDGGHGSTKLRRSIAHFLNRHLNPATPLDAEHMVVTNGCSSAIEHVSWVLTDPGEGILLGRPFYGTFIPDMSSRPGAAVVTVEFGDVDPFSEEAVSKYEEALLAFQRSSGKPVRALMLCHPHNPLGRCYPRKVLIELMRLCQKYRIHLVSDEIYALSVFANTVDEAPAPVDFESVLSINRDGIIDPSLVHGLWGMSKDFGANGIRLGVIISQSNPEVLGAIKATSLYSYASGITDHLVGNMLMDDAFTDEYVQENRKRLAESYAYAATFFKDNQIEYAPGVNAAFFLWVNLGRRYRELHADFSAEEVVNQKVMQNLLRERVFLSDGTLFGSEKDGWFRLVFTQPRDYLDLALKKILKALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU60</accession>
    <name>A0A9W9WU60_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="7">3.4.21.92</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_007835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="7"/>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787301.1">
        <property type="nucleotide sequence ID" value="XM_056937436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WU60"/>
    <dbReference type="GeneID" id="81627685"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000001">
        <property type="entry name" value="ATP-dependent Clp protease proteolytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001368">
        <property type="entry name" value="PRK00277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009205">
        <property type="entry name" value="PRK12553.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5475548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="262" mass="28645" checksum="17A7F2D32CC559A1" modified="2023-11-08" version="1">MNSPVVRTRLQQLCRSFTRCGAPRVQSALGARQFSSSITALDRTPPQGWTPTPFVTETVGGGWHTYDIFSRLLKERIICLNGQVDETMSASIVAQLLFLEADNPKKPIHLYINSPGGSVTAGLAIYDTMTYIAAPVSTICVGQAASMGSLLLCGGEPGKRYCLPHSSIMIHQPSGGYFGQASDIAIHAKEILRVREQLNKIYKHHLTGKKQLSLDEIEKLMERDYFMGAQEALDLGIVDEILDRRVQNSNKGGDGDGKPPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUH6</accession>
    <name>A0A9W9WUH6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5476939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787483.1">
        <property type="nucleotide sequence ID" value="XM_056936684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUH6"/>
    <dbReference type="GeneID" id="81626933"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5476939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="562" mass="62282" checksum="303C02CBD71F560B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV06</accession>
    <name>A0A9W9WV06_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="16">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">N7539_007146</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="16"/>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787546.1">
        <property type="nucleotide sequence ID" value="XM_056936747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV06"/>
    <dbReference type="GeneID" id="81626996"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF82">
        <property type="entry name" value="CYTOCHROME B2, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 19" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="21">
        <location>
            <begin position="59"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="138"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="361"/>
            <end position="365"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="384"/>
            <end position="385"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ5477002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="457" mass="49281" checksum="42C86BE8288AA9A7" modified="2023-11-08" version="1">MAKVLDAAEVAKHNTAESCWVILYGKVYDPEACLGTVDESTLPKDDKPAPAPEKATGPPPMQTLLNLDEIEEVATKQVSQKAWAYYYSASDDKVSKRFNNEVYRSILLRPRVFVDCTNCDLSTSALGHKLGMPIYVSPAAMARLGHPSGEAGIAEACRSFGAMQVISNNASMTPEQIVQDAAPDQVFGWQLYVQVDRKKSEAMLARINKLKAIKFIVLTLDAPVPGKREEDERNSLVGVSQPVSSGVKAAERAADGTPDVNGPGGSGGVGQQLFAGTDPSLTWQKTLPWLAQHTNLPIILKGLQTYEDAYIASLHAPRVKGIILSNHGGRALDTAPPAVHTLLEIRKYCPEVFDKLEVHVDGGIRRGTDVVKALCLGAKAVGVGRAALWGLAAGGPDGVRRTLQILADETKTCMRLLGVQTVDALGPQHINTRMVEQQIYDGPSALDSLRRTFRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV92</accession>
    <name>A0A9W9WV92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein phosphatase PP2A regulatory subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_007487</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787887.1">
        <property type="nucleotide sequence ID" value="XM_056937088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV92"/>
    <dbReference type="GeneID" id="81627337"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000011">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit A alpha isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="12"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="89"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="205"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="246"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="5">
        <location>
            <begin position="278"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="285"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="324"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="363"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase 2A Regulatory Subunit A helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="402"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="519"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="582"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5477343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="616" mass="69112" checksum="76A61FA46823535B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1I4</accession>
    <name>A0A9W9X1I4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucoamylase</fullName>
            <ecNumber evidence="9">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_006617</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="9"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788153.1">
        <property type="nucleotide sequence ID" value="XM_056936218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1I4"/>
    <dbReference type="GeneID" id="81626467"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05811">
        <property type="entry name" value="CBM20_glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000018">
        <property type="entry name" value="Glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034836">
        <property type="entry name" value="CBM20_glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046966">
        <property type="entry name" value="Glucoamylase_active_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008291">
        <property type="entry name" value="Glucoamylase_SBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF12">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001031">
        <property type="entry name" value="Glu-a-glcsd_SBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00820">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040906207" description="Glucoamylase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="13">
        <location>
            <begin position="508"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5480723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="616" mass="67697" checksum="C55C8B18C80B7B79" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1R5</accession>
    <name>A0A9W9X1R5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788194.1">
        <property type="nucleotide sequence ID" value="XM_056936259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1R5"/>
    <dbReference type="GeneID" id="81626508"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5480764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="304" mass="34031" checksum="9A6DE54C4A77581E" modified="2023-11-08" version="1">MAGLVNSPLAVFRRAESAKPLHTRWGDVTISVPTDGSWNQYENPHRAQERQLYGPGFVPDCSPADRSREGSVRHGPTRRTVKNGSVDEYRTGIIAERTSDESNSRRQSLSLGDLRPNRNRLSVRLASHPSQLRGDSLQTPGGESREQKKPEFAYKPIHQDYPSEISETPDHSKHRYRYIPTSGRYLEDIPSPHGSRSQSAMSSGKSSARRDSCIDSIKLYDRERGRVSARHHGHQSYHFREDDRHSVGSSVGGSSDSSGSGPLLTSTMRPRRRTSPFVAAGHRRSTSLRPMTMAMVPDPEDIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1T9</accession>
    <name>A0A9W9X1T9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein MSP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_006767</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788303.1">
        <property type="nucleotide sequence ID" value="XM_056936368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1T9"/>
    <dbReference type="GeneID" id="81626617"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000538">
        <property type="entry name" value="ATPase family AAA domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="146"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="379"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5480873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="421" mass="46171" checksum="87785B59D9181D41" modified="2023-11-08" version="1">MASSGGRRWQSFLQELVMVAGTSASAYFLIRYLLSRLEFDPESQKKEEQRQKSAAILRRLDGGDQSDDETSRGGSSKKSRRQRRGELSLNQYEQAVAMDVVAPEDINVSFEDIGGLDHIIEELKESVIYPLTMPHLYSSTSSLLTAPSGVLLYGPPGCGKTMLAKALASESGACFINLHISTLTEKWYGDSNKLVNAVFSLARKLQPAIVFIDEIDAVLGTRRSGEHEASGMVKAEFMTHWDGLTSANSTGEPQRIVVLGATNRMQDIDEAILRRMPKKFPVTLPPAQQRLRILSLILKNTKIDRDNFDLHFLVKSMAGMSGSDIKEACRDAAMGPVRELIRQKKAEGTQITAVDPSEVRGLRTEDFFARAGGVGVIPQASQIPTTPTGKVIEREDEEWATEDKASSNSGARPAGMAEPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2F2</accession>
    <name>A0A9W9X2F2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_007045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788581.1">
        <property type="nucleotide sequence ID" value="XM_056936646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2F2"/>
    <dbReference type="GeneID" id="81626895"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3N9</accession>
    <name>A0A9W9X3N9_9EURO</name>
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        <recommendedName>
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        </alternativeName>
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        </subcellularLocation>
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        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <property type="entry name" value="PRO-APOPTOTIC SERINE PROTEASE NMA111"/>
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        <property type="entry name" value="PDZ_6"/>
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    </dbReference>
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        <property type="entry name" value="Trypsin_2"/>
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    </dbReference>
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        <property type="entry name" value="PROTEASES2C"/>
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    </dbReference>
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        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="PDZ" evidence="11">
        <location>
            <begin position="308"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="11">
        <location>
            <begin position="879"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1004"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5483035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1032" mass="113355" checksum="B451D56CBE7A07CA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3V8</accession>
    <name>A0A9W9X3V8_9EURO</name>
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        <recommendedName>
            <fullName evidence="9">C4-dicarboxylate transporter/malic acid transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_006536</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056936138.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81626387"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TDT_Mae1_like"/>
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    </dbReference>
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        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
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        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
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        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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            <end position="60"/>
        </location>
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    </feature>
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            <end position="293"/>
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            <end position="318"/>
        </location>
    </feature>
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            <end position="25"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5483090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="42021" checksum="0E1DE123C94C2261" modified="2023-11-08" version="1">MYRRDGARKRGQRTTTSISPRHHARLPEEDQTGLARLRHLTWAWFALLMATGGLAPLLSPQTQPHFFQGLDVIGKVVYICDLVIFSTLITAMIYRFIRWPKTMRSSATQPRESIFIPTMSICLASMIASNSPYGIPSSGPWLLVTYRVLFWIYYAVTFYLWLFISADLHLEDMTPAWDLPILPFMLSGTIASVGGLGFLVSSAMFTVYLRWMTVFGLPEPSSRPAIFIAITAQVLNIVASVSSIFMWCLSFWLFSIAMVACLLAAREMRFSLSWRSFVFPNIGLIIATISIGRQLQSEVILWVGSVATILMAMLYLFIATMHVRAVIKHQILCKGQDEDMYEREAQPKTEKIPEYQDIGDAQCQKRDQRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X4Q8</accession>
    <name>A0A9W9X4Q8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000007">
        <property type="protein sequence ID" value="KAJ5483824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056935626.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81625875"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5483824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="123" mass="14186" checksum="919F235D00FF0A75" modified="2023-11-08" version="1">MSPSTRQALRKSVNNMSDPEKVPLLEPSNNVKELEATGDENLQYRNNGRDSKSSYSNTQTIIRMRLRPGPNGPRLSFLTVSKEGTKKKSGFQKIRSHVENTNPEEKRHDWMRRLRPKPHRCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5N0</accession>
    <name>A0A9W9X5N0_9EURO</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">N7539_004763</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056934365.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81624614"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:conjugation with cellular fusion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="BRCT_CHS5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13945">
        <property type="entry name" value="Chs5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000088">
        <property type="entry name" value="Chitin biosynthesis protein (Chs5), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chitin biosynthesis protein CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031673">
        <property type="entry name" value="Chs5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031669">
        <property type="entry name" value="Fn3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16892">
        <property type="entry name" value="CHS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16893">
        <property type="entry name" value="fn3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="75"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="163"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5484775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="408" mass="43727" checksum="A90D4F6472E70FB2" modified="2023-11-08" version="1">MLVSLTVGKVDAGVAVLLTEDNRLIEFPSVLLPAGIASGSIVDITVARNHAAETANATAFQSLQKRILNTYGVKTPSPPILRLRNATQTSLVLEWDPIDLATASLKSLSLYRNGSKAGSIPRPLETRSTKISGLAVHHEYTFHLVLRTTAGTYQSEKLTCRTHKMTDLSGITVTVGILDPQRKEALGHALDRIGGKMIDSVRIDTTHFVCSEGRGPLWEKAVEMNIPVVVPEWVDACESEGTIVGVRDYYLNADPKTRRLGTLHGSHQRTTSTMSTTSTVNPGRASLQPPPIQEEGPASTEPPLTPFPGGDMSGQPQAKDDEVGSDEDDELDVPPPPPPPKDEVSQQNGVAESGQKSGADSGDEDKLSSREGTLPQHMPEGGSQNADHNGTEKGKAKEGEEDFNEVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5Q2</accession>
    <name>A0A9W9X5Q2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short chain dehydrogenase/reductase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789707.1">
        <property type="nucleotide sequence ID" value="XM_056934513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5Q2"/>
    <dbReference type="GeneID" id="81624762"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391">
        <property type="entry name" value="RETINOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391:SF87">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G04120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5484923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="41482" checksum="834C7391873E24B2" modified="2023-11-08" version="1">MDNRPAPESRSHFPSHSAPRVWLITAGDSPIGISVARQALAHGDSVLLGLAHTAPDRDARRQDELEAFLAEIEEHRDEGWPERTRAVPLDIRMMSECQAVFAQAVAAFGRVDILLCCTSQALIGTVEELATSPQTQNLVRDQFEVNYFGPLNIIKAALPQMRRHHSGHIMILSGITAHIGTPGLGMYCAAGWALEGFCDSLAFEVAPFNVKLTIVQCSIEIGILTNLVTSVPPIFPAYSPSNNHAPLFRGILNHLIPRLPEAVAEGLIGNDSITSKPAESAESPRVNSIEDGPFSAPRVVTVHPPLSSAHLEVLVSETVHAITSIAGHENPPSRHIVGQEGVASVKEKLKTVSEELEDFIQASFAVDVAADAETGPPNTFPSQTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6K0</accession>
    <name>A0A9W9X6K0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc-binding ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_005406</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790202.1">
        <property type="nucleotide sequence ID" value="XM_056935008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6K0"/>
    <dbReference type="GeneID" id="81625257"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5485418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="106" mass="12040" checksum="531D2211B406B369" modified="2023-11-08" version="1">MVNIPKTRRTYCKGKPCQKHTQHKVTQYKAGKASLYAQGKRRYDRKQSGYGGQTKPVFHKKAKTTKKVVLRLECTACKAKKQLALKRCKHFELGGDKKTKGAALVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6Q6</accession>
    <name>A0A9W9X6Q6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_004693</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789489.1">
        <property type="nucleotide sequence ID" value="XM_056934295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6Q6"/>
    <dbReference type="GeneID" id="81624544"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF17">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="135"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5484705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="637" mass="72271" checksum="BF4A2F464FA2C937" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6U2</accession>
    <name>A0A9W9X6U2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_005381</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790177.1">
        <property type="nucleotide sequence ID" value="XM_056934983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6U2"/>
    <dbReference type="GeneID" id="81625232"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF14">
        <property type="entry name" value="CYTOCHROME B5 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5485393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="84" mass="9368" checksum="DBF9D31DF5121745" modified="2023-11-08" version="1">MSKSFTPADVASHNNADKGMYIIIDNSVFDVTKFVDEHPGGAKILKRVAGKDATKQFWKYHNESVLKKYTPKLKIGDVKDAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X763</accession>
    <name>A0A9W9X763_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">beta-glucosidase</fullName>
            <ecNumber evidence="10">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_005530</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="10"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790326.1">
        <property type="nucleotide sequence ID" value="XM_056935132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X763"/>
    <dbReference type="GeneID" id="81625381"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000006">
        <property type="entry name" value="Beta-glucosidase H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="395"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5485542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="813" mass="88686" checksum="9C7E07EB596E8D76" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7B8</accession>
    <name>A0A9W9X7B8_9EURO</name>
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        <recommendedName>
            <fullName evidence="7">Tho complex subunit 7</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
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            <taxon>Eurotiomycetidae</taxon>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056935011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X7B8"/>
    <dbReference type="GeneID" id="81625260"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
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        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="217"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="120"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5485421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="37674" checksum="645463DB8B11FD7A" modified="2023-11-08" version="1">MASYGLLGQPEEDALHKSRLLNVEEKPFKRISKRLLNPESLIADTSLPLTPPPDAAVDLTNGPDDKRQKRVEEWRTFREDVALDFAAFEGSIARIQFLLNSNEAERQRYASEKLAILDKMQAVRQNTIDLRSQLEEAQRLLALRKSYDDLADKITSNRLLKPREDQQANLQKLQTEIMELEKESKDYATTWAERREQFGRIVEEGMQLRRLIRDEKEEVERREGMQEGGDADDGDATSKGKPSAANSPLPDGEDTTPSHHSQDESSRLHVEKSFGAPGAASPLRQAVSAEANKGSREQEDANMADEGEVTAEDAGELSEELEEGEELPDERMDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7E5</accession>
    <name>A0A9W9X7E5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_005038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in spliceosome maturation and the first step of pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the SPP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789834.1">
        <property type="nucleotide sequence ID" value="XM_056934640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X7E5"/>
    <dbReference type="GeneID" id="81624889"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045166">
        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="G-patch" evidence="6">
        <location>
            <begin position="246"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="384"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="428"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5485050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="502" mass="56086" checksum="579F78565B33BF6E" modified="2023-11-08" version="1">MSYNPGAAAAAKKSAFSIQPRGSSDHFAGKSHSLARRPHRLGHDDDSSDEEQAPVHEEISGFDTLTGAQLTADGRAVSDSNQPLVIPVTSKNNWRDRPGTNVRKSKKNLLPPEVQALQEAQKNGQAQAEGAVEVEGPSMAYGLSFAQTMSKEEGKHIANGVESKSEVQVASTEKSKPMTDDQLALQALLRETTGEVERRTDLVIESSKLQEDETTEPHHDEASSFRADVASRPEPASLDQYNAIPVEEFGAALLRGMGWKDGQSIGRGNYSSSSPAQKTKTTNVPARRPGFLGIGAKDSGKGAEVELGAWGKSAMRKASRKQGEENADGNVEGVYMPVTMRNKRTGEYITEEELAELKKESSKPQIDKERWRDRGDRNLGSSGRAKDGHSREYRERNYSNERSGRKGVSSRRERSSSAGRYSSRRSGHHEDIHRRDERSHRDRQRDYDRDRDRGSARFDSDSRRDRDRERDRKNREDRYESSRHSSHSSRKDGSAYRSRRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7E9</accession>
    <name>A0A9W9X7E9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nuclear distribution protein nudE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_005650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790446.1">
        <property type="nucleotide sequence ID" value="XM_056935252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X7E9"/>
    <dbReference type="GeneID" id="81625501"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:kinetochore"/>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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</entry>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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        </source>
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        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
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    </dbReference>
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        <property type="entry name" value="AA-permease/SLC12A_dom"/>
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        <property type="entry name" value="Amino_acid_permease_CS"/>
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    </dbReference>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
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    <sequence length="539" mass="58882" checksum="F7C785C34A6DC7E9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCE0</accession>
    <name>A0A9W9XCE0_9EURO</name>
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        <recommendedName>
            <fullName evidence="12">DEAD/DEAH box helicase</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">N7539_003611</name>
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    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790754.1">
        <property type="nucleotide sequence ID" value="XM_056933213.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81623462"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23827">
        <property type="entry name" value="RWD_YLR419W-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000016">
        <property type="entry name" value="ATP-dependent RNA helicase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000868">
        <property type="entry name" value="DEAD/DEAH box helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001214">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056328">
        <property type="entry name" value="DSRM_DHX29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF267">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE YLR419W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24385">
        <property type="entry name" value="DSRM_DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26026">
        <property type="entry name" value="RNA_hel_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="6">
        <location>
            <begin position="326"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="RWD" evidence="7">
        <location>
            <begin position="389"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="569"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="808"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5488721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1357" mass="149475" checksum="FEF3EBE0074AD171" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCG2</accession>
    <name>A0A9W9XCG2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_003641</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056933243.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81623492"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
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        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="3">
        <location>
            <begin position="41"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5488751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="297" mass="32066" checksum="FB020AE1088EFA49" modified="2023-11-08" version="1">MSMASEASSATTTAAATTTTTTMTTFSAPLPATKSLPTNQSALAASFTSFLTVSVHQILFLRSVYPRATFLPVRAYNYPVRQSRHPKVCDYINDASIAVGTEILKGTITAVSIIISSLRTNQPLERYAFDLSGFPRVPAGDQNTTFEGRKDDTSASGVPGGPAPTSVDLEAQFRACLARLASACARLTPLPRDDEFSFTVCIEVREDALPPAGTTSEEQAWIVAEPGKVHLRSCTAPYSVSKVRNSETQQQTAPPASNGRAKTVPVRRVEAGELRLELWVEEARQKFNEPVESEPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCN7</accession>
    <name>A0A9W9XCN7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003744</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790887.1">
        <property type="nucleotide sequence ID" value="XM_056933346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCN7"/>
    <dbReference type="GeneID" id="81623595"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000024">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF67">
        <property type="entry name" value="MFS MULTIDRUG EFFLUX TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="572"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="111"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5488854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="611" mass="66018" checksum="A2B5F3FB497D720E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCT8</accession>
    <name>A0A9W9XCT8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_003821</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790964.1">
        <property type="nucleotide sequence ID" value="XM_056933423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCT8"/>
    <dbReference type="GeneID" id="81623672"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5488931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="200" mass="23254" checksum="EB2B81C863D72478" modified="2023-11-08" version="1">MVRRAVAIPKAAKNAFVPPSQRKQVFLPEFVIALARTPFLSPRYAQFRVPLNFNKLDLRDYLQNAYNVGVVSVRSYIEQQPITRITRDGRNIGAWRRPKAQKRMTVELREPFVYPEEPKDLSPWEKESWDASEKWQAKMQQGMQQKSHYAQEPDADARKAFEEQAKELKKAPEEWRPSSKALGLDLARRLSVRTGVKSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCY9</accession>
    <name>A0A9W9XCY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790929.1">
        <property type="nucleotide sequence ID" value="XM_056933388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCY9"/>
    <dbReference type="GeneID" id="81623637"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="879" mass="97867" checksum="83500C145850A41C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XD15</accession>
    <name>A0A9W9XD15_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790530.1">
        <property type="nucleotide sequence ID" value="XM_056932989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XD15"/>
    <dbReference type="GeneID" id="81623238"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="128" mass="14073" checksum="A266442396942D17" modified="2023-11-08" version="1">MTEVFASRSSPQLDGPTIIQNWRKEWRSDENQAGMLRPGEKSPAEELMDQQSTLEHGIYGPRPGSRNELWTDGHCWATILAANKSNAETPVMGTSGVTVIRDSQLPTTSLGASGRTENDQPVEIRSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE58</accession>
    <name>A0A9W9XE58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_004507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791650.1">
        <property type="nucleotide sequence ID" value="XM_056934109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XE58"/>
    <dbReference type="GeneID" id="81624358"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5489617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="67" mass="7271" checksum="5A23CB30004A5D13" modified="2023-11-08" version="1">MLESSRKKEAVKETTGTGLVDVNQRKRQTIGSTSTAFSAEQGAFWVLALAFDPSGRAWGLPDQGISW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE80</accession>
    <name>A0A9W9XE80_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_004554</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791697.1">
        <property type="nucleotide sequence ID" value="XM_056934156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XE80"/>
    <dbReference type="GeneID" id="81624405"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000008">
        <property type="entry name" value="Translation initiation factor 2B, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5489664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="440" mass="47864" checksum="2D07DD47B2A23C53" modified="2023-11-08" version="1">MPSTSLALTPGLGSFLKSLKTNPVETSIENLISLLKRRQIRHSRSCATATAYLLRHVVSVCKTSDPLKLIERVQTVGRRLVAAQPREMVVGNVVRRVLGLIRDEAEDDHDAEFALSEAGSESQPHTPRAFDDPSSSLPLDRDALSLRGDGAERQTSRPTLHSMFSLLSHPEAEFSPISTPGTQSPNGRMPPHGAGGKDVKAEVLEGIGEIIDELGQVDDQIASYALEHIHSNEIILTHTSSTTVQKFLVKAATKRKFTVIHAESFPNNHEATHATVSGKSVNDEENLSTEAFQKPLIALGITVILIPDSAVFALMSRVNKVILGTHSVLANGGLVAAAGTRVIARAAKVHQTPVVVVSGVYKLSPVYPFDFESLIEYGDASKVLPYEDGDLVDQIDVQNPIYDYVPAELVDLYITNLGGHAPSYLYRIVSDHYRKEDISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEE6</accession>
    <name>A0A9W9XEE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791844.1">
        <property type="nucleotide sequence ID" value="XM_056931885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEE6"/>
    <dbReference type="GeneID" id="81622134"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040743471" evidence="1">
        <location>
            <begin position="19"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5490715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="234" mass="25892" checksum="0597E81AE447E97B" modified="2023-11-08" version="1">MKLQIPIVSCLLASLGDALETRPKACGHFPTSIQEFTSGFQQPKPPMVKTEFQTSFIQHKWYFEYQQSQRQKCPVTDAAYHVRNANLSHVSSGYLYFSPSQKMVRADEAYEGALATSIFDYGNTTQQGLVMNTVTSYSVGSPKPSVWSGYVLSNYPLFAEDFLIKGDAVFGGLVTRNLLQGHVASWNIMFMGSIPVTAFVDACGVLVGYDYFSPGLRTRVTTDFFNTAVGPVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEM2</accession>
    <name>A0A9W9XEM2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_002278</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791840.1">
        <property type="nucleotide sequence ID" value="XM_056931881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEM2"/>
    <dbReference type="GeneID" id="81622130"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
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        <property type="project" value="GOC"/>
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    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049161">
        <property type="entry name" value="GH59_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02057">
        <property type="entry name" value="Glyco_hydro_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040735809" description="CBM1 domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="6">
        <location>
            <begin position="486"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5490711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="522" mass="54967" checksum="EE55BD88EFF819C4" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XER1</accession>
    <name>A0A9W9XER1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_002481</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792043.1">
        <property type="nucleotide sequence ID" value="XM_056932084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XER1"/>
    <dbReference type="GeneID" id="81622333"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562">
        <property type="entry name" value="NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562:SF2">
        <property type="entry name" value="SODIUM-HYDROGEN ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="9">
        <location>
            <begin position="71"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5490914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="535" mass="58513" checksum="054E59B6C4E19F13" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF94</accession>
    <name>A0A9W9XF94_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_002762</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792324.1">
        <property type="nucleotide sequence ID" value="XM_056932365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF94"/>
    <dbReference type="GeneID" id="81622614"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF33">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="13">
        <location>
            <begin position="5"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="242"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5491195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="677" mass="76135" checksum="E111F651823595C1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFG2</accession>
    <name>A0A9W9XFG2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="10">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exo-1,3-beta-glucanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_002791</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="10"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792353.1">
        <property type="nucleotide sequence ID" value="XM_056932394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFG2"/>
    <dbReference type="GeneID" id="81622643"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF26">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040805193" description="glucan 1,3-beta-glucosidase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5491224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="315" mass="34325" checksum="064E3AAB38742677" modified="2023-11-08" version="1">MRVSSILPIVLAAAPAVVSARGTLGFSLGDKLPNGDCKTTKDYELDFDNLKDLSTLVRTYSGSECKTPENIIPAAKNKGFKVVLGIWVGPQKKDDMSTNDASFQKDFAALKKTVPGNEDVIEAITVGSETLYRGDLTGPQLHKYISTVAKEFPKVTVGTADSWNKFADGTADDLFTTSPVVTYVLANAFAYWQGTVADKAYQTYFDDMSGAMSHIQKIAGSNADKIRVITGETGWPTDGGSDYENALAGTKNAETYWKTGVCGMLDWGVDLFYFEAYDEAWKPTSIGDNGKAMNENHWGLFTADRKLKFDTTCPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFI8</accession>
    <name>A0A9W9XFI8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_002565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792127.1">
        <property type="nucleotide sequence ID" value="XM_056932168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFI8"/>
    <dbReference type="GeneID" id="81622417"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.395.10:FF:000008">
        <property type="entry name" value="Ulp1 protease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="26"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5490998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="242" mass="27780" checksum="30F4F9D12E40231F" modified="2023-11-08" version="1">MLDGGLGKLQKRMRGHFGDRLSPDDAYLSYHDIRLTREDMQCLKNDWLTDNIISFWEEYLEHEFLVQYKTSHIVLLRPSMSFMLFQTPDPRTLRSALPDFSQTTHVFLPINDCNNKMQAEGGTHWSLLLISIVDGVAFHYDSLVFGNHDEARYVTGQFSKLLGRPLAFQHLRDSPQQDGGSDCGVFVCMNMRHILLKRLLMASSNEKVSMSLGGKKVDAHAARKEMAKIIEGFRKEGERRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGC2</accession>
    <name>A0A9W9XGC2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_003303</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 13">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792864.1">
        <property type="nucleotide sequence ID" value="XM_056932905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGC2"/>
    <dbReference type="GeneID" id="81623154"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000015">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000024">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005589">
        <property type="entry name" value="PRK07314.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="14">
        <location>
            <begin position="1"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="12">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5491736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="428" mass="45355" checksum="027E54E729933ADF" modified="2023-11-08" version="1">MRRVVVTGLGAVTPLGVGVRRTWKRLLEGHCGIVNVVSRDERFREIPAQIAAVVPKGKKEDGGWTVSEWMNRGDERVMAKFAQFAMAAAEEALSDARWKPTTPEEQHATGVCLGSGIGNFDEIYDTVVAYEQGGYKKVSPLFVPKLLINLGAGHISMRYGFMGPNHAATTACTTGAHSIGDAARFIACGDADVMVAGGGESCIHPLAIGGFARARSLATDFNDDPEHASRPFDADRKGFVVGEGAAMLVLEELDHARGRGVPIYAELKGYGCSADSHHITAPKENGEGAYMAMKKALKQAQVQPAAVDYINAHATSTIVGDAAENAAIKTLLLGSEGKNRAIDVNVSSTKGAVGHLLGGAGAVEALFTVMAIRDDMMPPTINLTRLADGFDCNYAPNEAQPRNIDIALTNSFGFGGTNSSLCFARFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGF3</accession>
    <name>A0A9W9XGF3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_003238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792799.1">
        <property type="nucleotide sequence ID" value="XM_056932840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGF3"/>
    <dbReference type="GeneID" id="81623089"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5491671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="117" mass="13252" checksum="DD46208624EEA0A3" modified="2023-11-08" version="1">MNLANSLANKQVESYIVERGYFEDQKPESKVAKDHRPLFCFICVGQENLALKKRVQRFSSHGDVSKHIKRKHLRNLVSSSAIACNVCDKTFAEVMNFQRHASDSHSTVTGLLWSTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGM9</accession>
    <name>A0A9W9XGM9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LPXTG-motif cell wall anchor domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792996.1">
        <property type="nucleotide sequence ID" value="XM_056930965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGM9"/>
    <dbReference type="GeneID" id="81621214"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="745" mass="80450" checksum="77437B640B93475A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH18</accession>
    <name>A0A9W9XH18_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793241.1">
        <property type="nucleotide sequence ID" value="XM_056931210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH18"/>
    <dbReference type="GeneID" id="81621459"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5492861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="356" mass="38097" checksum="609C10817C905CA4" modified="2023-11-08" version="1">MPSYQRSSPRVARVQSAPEAKADPKQALAKVVPKSGVWRIPSPARFVLVVLGSLVLSSTLFTFTYGFTQGDLGLVSKHLEEWWEVGGLIAWRGVEVALAWLVGFDSWDVASFLFLTHLPTNSLLSAFYHVRPTSVFLSYAITILSTVIPFALLRRPASVHDLSHAPSGTVANRAILQDRPTTVYTTLVATAIYSVCLYASYASWLPARLVVHFEGLPDISVAHAGPAGLPVLFMTLIPAGIAARDFLFVSSTGHSVTRLEKAKAAAAAAAAAVDEEEYLITSLYRKTVGQLSAKTRILTSRTLLLAIGVFLNTVTQVAGTVRGVSIEGAATWGAVWTVSTLAVGATFGWIEAVDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH19</accession>
    <name>A0A9W9XH19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS0</name>
        <name evidence="10" type="ORF">N7539_001634</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH19"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000010">
        <property type="entry name" value="40S ribosomal protein S0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032281">
        <property type="entry name" value="Ribosomal_uS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16122">
        <property type="entry name" value="40S_SA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS2 C-terminal" evidence="9">
        <location>
            <begin position="205"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="241"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5492888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="302" mass="32381" checksum="7B8733E1F3E884BF" modified="2023-11-08" version="1">MAPSQLPPVFNPTSQDIEMLLAAQCHLGSKNLQVHMEPYLWKTRPDGVNVINIGKTWEKIVLAARIIAAIDNPADVCVISARPYGQRAVLKFANHTGATAIAGRFTPGNFTNYITRSFKEPRLIIVTDPRTDAQAIKEASYVNIPVIALCDSDSPTDFVDVAIPTNNKGRHAIGLVWWMLAREVLRLRGTLATRETEWDAVVDLYFYRDPEAEENKEIADESKVASAEEVGAGAIESGFAGENWDASAPGAGNPGTAFAAASAAVGATSWEADGADWAASSAPQGEWAAESQPAAASGETKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH56</accession>
    <name>A0A9W9XH56_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sulfotransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_003094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792656.1">
        <property type="nucleotide sequence ID" value="XM_056932697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH56"/>
    <dbReference type="GeneID" id="81622946"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053226">
        <property type="entry name" value="Pyrrolopyrazine_biosynth_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419:SF1">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5491527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="41742" checksum="6CECCEAA27B3A496" modified="2023-11-08" version="1">MNDKPSSSDSPRGVFLVSYARTASNLLCKILALDEQPRAFSNPSSGYYFRPAFLPHWVTGKPYRPIGEISAKETQERQECFQRSYEDLERDAHSAREQGKIHFFKEHALWISNPAAIAEWMGEPNLHPPAVFRVHPVGDSELEKAPSSTWSPENQTVMSDQVLQKWRLVFLVRHPALAFPSYYRASLAVRSHQGLHDSEMEPLLRASLTLRWSRFLYDWACKTDPHPLMLDADDVILNKAALAQFCTDIGLDATRLRFQWESRADTGAQEGNPPPKQEQQTKDEDEHKEKSKTPFHKIFGSTLLKSSGVMKTKSQSDLDIATEAAKWKSEFGVDMADLIEKCVRDAMPDYEYLHAKRSYANLAGENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHI2</accession>
    <name>A0A9W9XHI2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ArsA/GET3 Anion-transporting ATPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_001868</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the arsA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793502.1">
        <property type="nucleotide sequence ID" value="XM_056931471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHI2"/>
    <dbReference type="GeneID" id="81621720"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="11">
        <location>
            <begin position="27"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5493122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="340" mass="37603" checksum="8735CF576FF5665F" modified="2023-11-08" version="1">MSSAVVHNDDLDMEPTLQSILNQKTLRWIFVGGKGGVGKTTTSCSLAIQLAKVRKSVLLISTDPAHNLSDAFGQKFGKEARLVDGYTNLSAMEIDPNGSIQDLLANGDGQGEDPLAGLGMGNMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYETIVFDTAPTGHTLRFLQFPTVLEKALAKLSQLSSQFGPMLNSILGARGGLPGGQNMDELLQKMESLRETISEVNSQFKDPDMTTFVCVCIAEFLSLYETERMIQELTSYGIDTHSIVVNQLLFPKDGSNCDQCNARRKMQKKYLEQIEELYEDFNVVRMPLLTEEVRGKEKLEKFSDMLVHPYVPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHQ8</accession>
    <name>A0A9W9XHQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_001947</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793581.1">
        <property type="nucleotide sequence ID" value="XM_056931550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHQ8"/>
    <dbReference type="GeneID" id="81621799"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000106">
        <property type="entry name" value="Protein-tyrosine phosphatase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="56"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="270"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5493201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="426" mass="47324" checksum="57816948D34F76A5" modified="2023-11-08" version="1">MAHPSIKINTNVQATKRGLPNESDGGDVPADLGNCRLETGNTDNVPPFLCQSVSDIHEKFDDLEWIQRQRLADGMLSNDPAHPFALEGDPQVKARNRYVNVQAFANSRVHLQVPEGECDFINASPIVLKDSVTQEARTYIATQGPKLGHLAHFWHMVLQESKDEAVIVMLTQTFEGGREKCSQYFPLDLEQATMILSDNESDPFVATEGSPDETPPNAGQVTLLESTFDKKSRSEVRKLELTMGSESKIVWHYLFAGWADYSKPEGSDRAALLELIQSSAAKAGPDNPRIVHCSAGVGRTGTFIALDHLLQELESGQLLQVDDPTVDPIFETVNQMRQQRMMMVYNEMQMQFIYEVLREQVDLKLGNLSVRAKDSPASNYDEPRSAKLAKLSAHNDYLPTSKPELEETTPAQIPSPSETSQSSSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XID7</accession>
    <name>A0A9W9XID7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793299.1">
        <property type="nucleotide sequence ID" value="XM_056931268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XID7"/>
    <dbReference type="GeneID" id="81621517"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5492919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="481" mass="52630" checksum="20B80E6E5C5DAE48" modified="2023-11-08" version="1">MAMQYFNQIKDRRRPSQISSSHNPVLTPEDEAFLTKVTSDPETQPEPVPQNESRPLEGPAGDSGALVADNKPHEATSAAAPAEELGKQLGEAERLKEEQKIGVKKDTEPVKSNVAPTADKKKNRWSSMLWKKSAASKKPSSTANDATPSATEARQEQEDMTDILDRLNLAADNNRVFSLSDETQELLRKFKFVFKDLVNGVPTAYNDLEMLLTNGNRQLQETYTKLPTFMQKLIEKLPQKWTDALAPEMLAVASERAGRTGINMENVGKAASMAQKAGLNVPSLKELVSKPAAIAGMLRSIMEFLKARFPAVLGMNVLWSLALFLLLFVLWYCHKRGREVRLENERLVTEEEIRMLNEETSETPIRPSQTLLTVAPQGASAEEVREGVKKVEEAKAAAEKEDANAATEKEAASEAPSTASQPAAVPEPGPEPSESRTAAETSTSAAPRPAAVPTRTKSFLSMWSRTKSDSSSSKVSPYPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XJ21</accession>
    <name>A0A9W9XJ21_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Blasticidin-S deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_002261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793895.1">
        <property type="nucleotide sequence ID" value="XM_056931864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XJ21"/>
    <dbReference type="GeneID" id="81622113"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5493515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="129" mass="13892" checksum="7D0803A8FDF6A64E" modified="2023-11-08" version="1">MDLTPAELELVDTAKGDHRFDPTLCVASAAISADGRTFSGVNIFSFRGWSLCQAGVLGNATAANAPQLMSIVAVRGKADDEGRILSSCGRCRQVLWDLQLQIKVIVSKDGKLQSIPNKTLLPFAYDHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XL83</accession>
    <name>A0A9W9XL83_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_000143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794040.1">
        <property type="nucleotide sequence ID" value="XM_056929747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XL83"/>
    <dbReference type="GeneID" id="81619996"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040974753" description="Peptidase A1 domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="44"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="406"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="475"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="478"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5495027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="585" mass="62619" checksum="84A1D17429BA6107" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLA7</accession>
    <name>A0A9W9XLA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_000099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793996.1">
        <property type="nucleotide sequence ID" value="XM_056929703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLA7"/>
    <dbReference type="GeneID" id="81619952"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14234">
        <property type="entry name" value="DUF4336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5494983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="269" mass="30382" checksum="1BB25A4E1F0A1171" modified="2023-11-08" version="1">MPTLFPSNPSETMVIRDITPNMVTMSLPFARFGLVRFGGRGTLVRLASGSLAVFSPVTLTPEVRAKIDSLGGNVKYIAAPDLQHHLHVGPWKEAFPQASILAPEGLYEKRQKSNYNDAPFEHVYRKDKPQSISEEFDAEFECEYVHGHGSRELVFFHRPTRTVIEADLLFNMPAKEQYSRSPEGKSINFLTKLAIPVMNTEGSATGQRRFAWYLLAAKDRPAFTESMKRINTWDFDRLIPCHGDVIETGGKGVFQKVMAWFLEDGKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLG6</accession>
    <name>A0A9W9XLG6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_000282</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794179.1">
        <property type="nucleotide sequence ID" value="XM_056929886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLG6"/>
    <dbReference type="GeneID" id="81620135"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346">
        <property type="entry name" value="FUN14 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346:SF0">
        <property type="entry name" value="RE45833P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5495166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="173" mass="18196" checksum="DA6296F523E46EA7" modified="2023-11-08" version="1">MAFALFSPPSTILRLGLGLGIGLSAATLYPQSPFRAAPLRCDWPSSGSGSASRPTAAEINFTGRSSSSTEAGIATQAKNALLTPENMRQISLGSVLGLVAGVGLRAFSKVLVVVLGMGVVLVEWAASKGYNIVPLERVTGFIKNTNVRRMVNENRPFKISFGAMMAMAAFAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLM4</accession>
    <name>A0A9W9XLM4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794319.1">
        <property type="nucleotide sequence ID" value="XM_056930026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLM4"/>
    <dbReference type="GeneID" id="81620275"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="66" mass="7511" checksum="8B8528857859375E" modified="2023-11-08" version="1">MTSDLLSRFRKAFGSSTELVRKQRPRLDHPDQMAPRTKTAEAMRFPYAHYALLPCPDDEALEMGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLT5</accession>
    <name>A0A9W9XLT5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_000464</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794361.1">
        <property type="nucleotide sequence ID" value="XM_056930068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLT5"/>
    <dbReference type="GeneID" id="81620317"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF694">
        <property type="entry name" value="AMINO ACID PERMEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="45"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5495348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="466" mass="49878" checksum="B79E921CC9019AC3" modified="2023-11-08" version="1">MANLNDDIKAAPSYDEGARPELAKAEAEEVNEVFRTGEGQVDFRTVSWIRAGIIFLKIIFATGVLSIPSLMYELGAFPGAVNVVGWTVLNTYCAIIQGNFRNRHPGCHSIADMSHVVGGPILKEIVGMLFTVSYVIVAASGIIGVSTALNALSGHAICTVWFTFIATVIIAGFASVRKFSHIGWLTWVGFASVYIAVFIIVVGVTTRDRPAAAPSTGEYDFGYRVIGNPSFTTGITAAATIFVSSAATSAFLPVISEMRKPRDYPKAVYLSMSLVTASYLTFSLVIYAWCGQWIASPSLGSAGPTVKRVAYGIALPGLIVSGCLYVHVAAKYLFVRILRNSRHLQTNTVIHWGTWLSCTVGMAAISFLLACAIPIFNYVLALVGALCFAPLALCLPGWLWLYSYRDYCRGSLLQRTAYAAHVVLILLGAFLTVGGTYGVIVQINQAYADGSISSAFSCADNSGSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLY6</accession>
    <name>A0A9W9XLY6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell pattern formation-associated protein stuA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Stunted protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_000583</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794480.1">
        <property type="nucleotide sequence ID" value="XM_056930187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLY6"/>
    <dbReference type="GeneID" id="81620436"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0183">Conidiation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="9">
        <location>
            <begin position="109"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="268"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="697"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5495467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="884" mass="97591" checksum="8AA172291D2A56A8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLZ7</accession>
    <name>A0A9W9XLZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Subtilisin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_000459</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Serine protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794356.1">
        <property type="nucleotide sequence ID" value="XM_056930063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLZ7"/>
    <dbReference type="GeneID" id="81620312"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000006">
        <property type="entry name" value="Autophagic serine protease Alp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040939129" evidence="10">
        <location>
            <begin position="22"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="12">
        <location>
            <begin position="43"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="11">
        <location>
            <begin position="179"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5495343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="493" mass="52069" checksum="FFC492F5C50A2167" modified="2023-11-08" version="1">MKGLLSLTLFPLLAAASPTWSESIHNGAAPVLSSTSAKEIPDSYIVVFKKHVGASAASAHHSWVQDIHSDTMRMELKKRSLFGSDSDPYLGVKHTFHVAGSLMGYAGHFHEDVIEQVRRHPDVEYIEKDSEVHHFEDPAIEKNAPWGLARISHRDSLSFGTYNKYLYAEDGGEGVDAYVIDTGTNINHVDFEGRASWGKTIPQGDADEDGNGHGTHCSGTIAGKKYGVAKKANVYAVKVLRSNGSGTMSDVVKGVEWAAEAHIKKAKAAKDGKAKGFKGSVANMSLGGGSSRTLDLAVNAAVDAGMHFAVAAGNDNADACNYSPAAAEKAVTVGASTLGDERAYFSNYGKCTDIFAPGLNILSTWIGSKYAVNTISGTSMASPTSLPASDSAFAVEEITPKKLKDALITVATSGALSDIPSDTPNLLAWNGGGSSNYTEILSKGGYKAGASDSMKQHLDELVGKVEEVIAKEQKVLSHELGAIYSEIKDAISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM90</accession>
    <name>A0A9W9XM90_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794601.1">
        <property type="nucleotide sequence ID" value="XM_056930308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XM90"/>
    <dbReference type="GeneID" id="81620557"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11392">
        <property type="entry name" value="bHLH_ScPHO4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
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</entry>
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
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</entry>
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        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN28</accession>
    <name>A0A9W9XN28_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
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                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794287.1">
        <property type="nucleotide sequence ID" value="XM_056929994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN28"/>
    <dbReference type="GeneID" id="81620243"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="336" mass="38316" checksum="D25CD6CC0067A653" modified="2023-11-08" version="1">MGSDNSQPSIPEWRVDRFDLSPYEFSFPRLLLSALGLPSFPFLDSIEEWDNQWPLNFILYSSYSPTHLEQQACGGANTGAGVFSSRTLADRNPKEPQWREAFEDLIRLENGIPMLDRNRIIDGRAENSDEWLLGMLRRGSMGPRFSRFTLEERPGGSFYHHHLKPREPVMEFGSEEELAMYEQFLEDLDVQRRELPAAFQQSQILANVMRIKGTREDQAPNPRDSNKMELQGNAKGGKGNHGSEQSGDFSQGSPSDSTRIISTMSQTEKTHYSDGTVSSRRIVTRHYADGREETDTFVETDLSHVNEDWNDGIADTSRRNESEPNPKSKGGWFWND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN49</accession>
    <name>A0A9W9XN49_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MmgE/PrpD family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_001184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795081.1">
        <property type="nucleotide sequence ID" value="XM_056930788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN49"/>
    <dbReference type="GeneID" id="81621037"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF8">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="2">
        <location>
            <begin position="16"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="3">
        <location>
            <begin position="287"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5496068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="51884" checksum="3F5389F13953FF14" modified="2023-11-08" version="1">MASQTSTETMDNTRTERLAIWAANLKFTDLPTDVVEKTKDFFVDWLGCTIAGRHHPAVQAISKFASHMGPSSGKSEVLDGALGFTTSAAFASLVNGASSHVVEQDDLHNRSIMHPATVIFPAALAVAQDVEATGAEFIAACVVGYEVGCRVGRYLGKTHYEVLNLRSRFHSTATGGVIGVAAATAHLLKLDAEQMLSAIGTAGTQAAGLWQFLIDATHSKQVHTGKACFDGIFAAYTARDGLLGTRDILEGPRAMGVTLVPGTTNAEAIDGDLGNDYEILHSSFKWHASCRHTHPSADALLKLMKNHNLVFEDIESVVAHTYQAAINVLGMTGKGETVHQSKFSMGFVLAVVAKKGQAMITDFGEDDLEDSSLREFQQRVKMELDPEIDRAFPEKWKGTVDVRTKDGQSFTESVEFAKGDPELPLTRDEIERKVHNLAKYGGFKDTQRVQQLIERGWRLNTDLNLAGFVFGSSSKPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN69</accession>
    <name>A0A9W9XN69_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795110.1">
        <property type="nucleotide sequence ID" value="XM_056930817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN69"/>
    <dbReference type="GeneID" id="81621066"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5496097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="55883" checksum="74EA09B4ED1C2FA0" modified="2023-11-08" version="1">MSVESPGPSHQKSGFRSLFANALRPKKSRQTLRKSSVNRSTPDLRYAARASTDEGPPPMPELAPLQAHRLKYQQHHAQLDSQLGERRDYTAMIHTLGLLDPDDRYLPAQIDNDRREPGEPDMEKLSPELWTRIARLLNPADAASLASASRTLYQKLGKAPFAALRHPDNYTYRINFLIRLDQSLPHHLLCFPCGRYHRRTQEGLERLKPSHVINPLFTCPHAQNPLNPQPRSRITHGRTIPFSFVQLATRAHYYGPQYGLQATDLGRRWERDGWSHTSRFHIHEGRLLMRVASQTFAAAGLTSSAQRMLLYSREDYWPFFSACAHWRDGELMPACKCALEHIPKPRETAGLQGLEHKVKDRISGTRFDPNSIVTLCGFCRPMRRCPECPSEYLIEIKLAEDKSHIRGSVFKQALVVTRWTDLGDGTSPAGPEWGAINGLKDDYDSFSHSHYAKRGIASIFEAAFTADTLPGQRVISMNPKRKKLGERGHGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XNT8</accession>
    <name>A0A9W9XNT8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794662.1">
        <property type="nucleotide sequence ID" value="XM_056930369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XNT8"/>
    <dbReference type="GeneID" id="81620618"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14011">
        <property type="entry name" value="PK_SCY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="657"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="830"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="860"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="891" mass="97706" checksum="5F043D839918565A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XP25</accession>
    <name>A0A9W9XP25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794782.1">
        <property type="nucleotide sequence ID" value="XM_056930489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XP25"/>
    <dbReference type="GeneID" id="81620738"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="58987" checksum="0CFECDA8B2F122FF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XP87</accession>
    <name>A0A9W9XP87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_001186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795083.1">
        <property type="nucleotide sequence ID" value="XM_056930790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XP87"/>
    <dbReference type="GeneID" id="81621039"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090324">
        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052000">
        <property type="entry name" value="ETFRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024:SF0">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5496070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="72" mass="8388" checksum="BF6383BE1C55F4CC" modified="2023-11-08" version="1">MVNNELRRQVISIYKGREYPLGFQYFRDRLHRAFAGQAHLTDEDQIRKGIARAEFVKKGTSTNTCLDEMAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNC9</accession>
    <name>A0A9X0BNC9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-CoA hydrolase</fullName>
            <ecNumber evidence="4">3.1.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetyl-CoA deacylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_008309</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O = acetate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="3.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.1" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787001.1">
        <property type="nucleotide sequence ID" value="XM_056937909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNC9"/>
    <dbReference type="GeneID" id="81628159"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.70:FF:000002">
        <property type="entry name" value="Acetyl-CoA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000003">
        <property type="entry name" value="Acetyl-coA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.20:FF:000001">
        <property type="entry name" value="Acetyl-CoA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.70">
        <property type="entry name" value="4-hydroxybutyrate coenzyme like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="entry name" value="Acetyl-CoA hydrolase/transferase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046433">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43609">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43609:SF1">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase C-terminal" evidence="10">
        <location>
            <begin position="333"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5475243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="525" mass="57805" checksum="13FE3D5B943C7789" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BS93</accession>
    <name>A0A9X0BS93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788304.1">
        <property type="nucleotide sequence ID" value="XM_056936369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BS93"/>
    <dbReference type="GeneID" id="81626618"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5480874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="68103" checksum="388D4FF40A9B8002" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSL3</accession>
    <name>A0A9X0BSL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peroxiredoxin PRX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_006635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788171.1">
        <property type="nucleotide sequence ID" value="XM_056936236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSL3"/>
    <dbReference type="GeneID" id="81626485"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="8"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5480741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="222" mass="24749" checksum="17BFD96DCBB8D4B6" modified="2023-11-08" version="1">MATERAPLRLGSTAPNFDAETSTGPINFHNFIGDKWTILFSHPDDFTPICTTELGAFAKLEPEFTARGVQLIGLSANHVESHHRWIKDIDEVSGSQLKFPIISDPERKVAYLYDMVDYQDTTNVDSKGMALTIRSVFIIDPAKKIRLIMTYPASTGRNTAEVLRVIDALQTTEKHGVTTPINWLPGDDVVIPPPVSTADAKAKFGEIREVKPYLRFTKDPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSR0</accession>
    <name>A0A9X0BSR0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trehalase</fullName>
            <ecNumber evidence="6">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_006304</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788830.1">
        <property type="nucleotide sequence ID" value="XM_056935906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSR0"/>
    <dbReference type="GeneID" id="81626155"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000026">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011120">
        <property type="entry name" value="Trehalase_Ca-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF6">
        <property type="entry name" value="CYTOSOLIC NEUTRAL TREHALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07492">
        <property type="entry name" value="Trehalase_Ca-bi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neutral trehalase Ca2+ binding" evidence="8">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5482858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="734" mass="84068" checksum="7BB1940E3696FDD9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BT18</accession>
    <name>A0A9X0BT18_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_006125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
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    </dbReference>
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    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040824798" evidence="7">
        <location>
            <begin position="26"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
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        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5482679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="386" mass="40034" checksum="CDB227CB5CD86EF3" modified="2023-11-08" version="1">MQLLSKASAPATLVGLLHLAAIANAGPFAFVENVFERSCANPCGWNRQLCCSASQACSTNAANQAVCVDGAGSGGGSWQYFTTTEVDQSTITTIYSSWVQAPAPTATSTGTCRLGLGESTCGSICCDAAQECVDGECVTASSSVAVTGAEATPGVRATSSGESTVTQTVAPTTTQGFIAPVGTDGADLIGVKAAGSSGLSGGAIAGIVIGSIVGVILLLLLCGCLCFRGVLEGLLAALGLRKRRRRETSVVEERYSHHSHGSRPPPAKRTWFGAKPAVEGTESEVGEKKSKFSWAKIAIILGALALCLGLKRRKDQDDDDAKTDYTYPSSYYYYSDYTQIKALVDAQETHGDLANPGEAQGAEGHTGNEAMCISRSWLQLGPLKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9X0BTQ8_9EURO</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <strain evidence="1">IBT 30728</strain>
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    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Petersen C."/>
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000007">
        <property type="protein sequence ID" value="KAJ5483862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789132.1">
        <property type="nucleotide sequence ID" value="XM_056935664.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81625913"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="KAJ5483862.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="68" mass="7970" checksum="B2A0AD5F0F5321CD" modified="2023-11-08" version="1">MQIFSGDLCKSDFGRDYGRGSEDYKATLLRLSTTGYHRIQTRMTSVIVHRRTLYEYYYEALLTLSAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUB4</accession>
    <name>A0A9X0BUB4_9EURO</name>
    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="2 3">
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            <strain evidence="2">IBT 30728</strain>
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    <reference evidence="2" key="2">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789269.1">
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    </dbReference>
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    <dbReference type="GeneID" id="81625646"/>
    <dbReference type="Proteomes" id="UP001148312">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5483999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="112" mass="11998" checksum="A9A56042B4A9A870" modified="2023-11-08" version="1">MVAAAIRPISLRLFVLVLTPFSRVSLGLLIPQLLPQFSKQDPGVSFLTRQREPTTNEPAEQPNPEDAPTETMIATPTSPCGADACTKPGTLACSSCEKPKPQYCSAACQKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUF0</accession>
    <name>A0A9X0BUF0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">N7539_005116</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485128.1"/>
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    <dbReference type="GeneID" id="81624967"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="158" mass="17469" checksum="D05E75DA352C3FE1" modified="2023-11-08" version="1">MENSNSSFSCVISSVVFFWVDTLVSLPFVSRNSREWITCSSVSRTNPAKTWATGNRGRDAPPVVTRWLCLVSPVVHRSGANAKIVAVWLSDITSTWLWRGSPIANPAEDCCSRTLGGSLPNGIERILTQLRLFGLFWGIGRGLTDNSNFAFREPPPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUH1</accession>
    <name>A0A9X0BUH1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin cortical patch SUR7/pH-response regulator PalI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_005176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056934778.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81625027"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF7">
        <property type="entry name" value="SUR7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5485188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="27717" checksum="62C60F00F52DC5E0" modified="2023-11-08" version="1">MSRVKGIASLILAFVAFVVILCCLFAGTTPRALDSVNLLRLYTPEGNSISSPHDFYSIHVMSYCQGIINAMPAGTTDPFGSLDIRSCSNRTVLFSFDPTIAWPRNLTHGAQLQWPRVISDDFRAFQMTSRAMAVIYSVGVGAIGAVLVVKILALSVPRLPLGVFDVGFMLLSTLCIGIASVIANVLAFELVQLINAHGDGSNVYAQYGGKFLGMTWASTALMVLGTWFSFSNAFSRGQEPAPASEEHALAPSKDEEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUU5</accession>
    <name>A0A9X0BUU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vacuolar amino acid transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_004968</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789764.1">
        <property type="nucleotide sequence ID" value="XM_056934570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUU5"/>
    <dbReference type="GeneID" id="81624819"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="164"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5484980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="567" mass="61041" checksum="0895E2C5B02AAEE0" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BVD6</accession>
    <name>A0A9X0BVD6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_005538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790334.1">
        <property type="nucleotide sequence ID" value="XM_056935140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BVD6"/>
    <dbReference type="GeneID" id="81625389"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046359">
        <property type="term" value="P:butyrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00567">
        <property type="entry name" value="ACAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000037">
        <property type="entry name" value="Similar to acyl-CoA dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF34">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="159"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="265"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5485550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="51347" checksum="C624D4E4F7C0E89F" modified="2023-11-08" version="1">MNFELPKELVHYIESIERFVEKEILPLQHADDNNRFFDHRREHSRTDWDHDGNPRPEWEDLLNQARILADEAGFFRFALPKQYGGQGHPDTNLWMSAIRFHLSSHPVYGGGLGLANDLQNEHSIVGNFPDVLMLHHFGNSEQRGEFIPARLQGEFRTTFGLTEPDHGSDATFMTTIARRQRDGFEISGAKKWQTGAHHCTHFLIFARTSGLAGSSRGITAFLVPRETPGIRIASYEWTLNMPTDHATVELNRVWVPDSAVLGAVDQGLAIAQTFVHENRIRQAASSCGAAKFCLDRSIERARSRQIWGEGKMLADNQAIQFPVVELMTQVEMLRLLILKTSCDMDRIVAASKAGDISQPPLVAIERQLSDKVAMCNFWANRLCCQAADRAIQIHGGDGYSRHYPFEHIYRHFRRYRITEGAEEIQMRKIAAYLFGFVGPKRDIKAGRGVPSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYM8</accession>
    <name>A0A9X0BYM8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_004277</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791420.1">
        <property type="nucleotide sequence ID" value="XM_056933879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYM8"/>
    <dbReference type="GeneID" id="81624128"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="9">
        <location>
            <begin position="176"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5489387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="267" mass="29796" checksum="948C873CC957D41E" modified="2023-11-08" version="1">MSQPPFQISAHPYSSTTPPTMNSPLNAETPPPPPPKPNSHEASRRGTPQNMTSLPMPQQPQSNYRPDSQLSQVEQAHTHDVLSSAPLPAPPTAAEGWIPEVLKDKSTKDLQTILQDPTLISALSTQHPSHAARQQNLESLLHVNQDLAARLLELQRQVSELRSQTEKMLLTHQSLEVSWRKKQAEMDTALAPWSPKALYQRLSAAIAEQEAVCHAVEESFLDEDHHGRATEKEVADWIRRVRAEASKLAARKEAKARWDEGRVGGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ52</accession>
    <name>A0A9X0BZ52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_002485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792047.1">
        <property type="nucleotide sequence ID" value="XM_056932088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ52"/>
    <dbReference type="GeneID" id="81622337"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802:SF1">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010372">
        <property type="entry name" value="PaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5490918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28003" checksum="F23782B71BD6F073" modified="2023-11-08" version="1">MYSKPVHAETSIKALFEFIKANPLGVLTTAIPSSTHHLIQSTHIPWILDPVTDDPNAPIKGRLRGHMARQNPQSKRMMDACTQSRSNPLQQEVMVLFTGAEHHYVTPKFYTETKPASGKVVPTWNYAAAQVYGRATIHFDTAAPETGQFLSEQLHALSQHGETSVMGYTGADGKPGPWKVSDAPERYIEVMKKAIIGIEVTIESIDGKVKMSQEVPAGDRRGVVQGFKEMGSDVGDHIAALVEKCGAKKDAERGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZG0</accession>
    <name>A0A9X0BZG0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_002694</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792256.1">
        <property type="nucleotide sequence ID" value="XM_056932297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZG0"/>
    <dbReference type="GeneID" id="81622546"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03707">
        <property type="entry name" value="EFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
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        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 11" id="KW-0251">Elongation factor</keyword>
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    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
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        <location>
            <begin position="50"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5491127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="439" mass="48210" checksum="691396C50E1C034E" modified="2023-11-08" version="1">MSSITRSLNLLARTGRSSLLRPRAVNPVHHVFASDKVAARGLATAFERTKPHVNIGTIGHVDHGKTTLTAAITKHQASKGLANFLDYASIDKAPEERKRGITISTAHIEFQTEDRHYAHVDCPGHADYIKNMITGAANMDGAIVVVAASDGQMPQTREHLLLARQVGVQKIVVFVNKVDAVEDDEMLELVELEMRELLSTYGFEGEETPIIFGSALCALEDRRPDIGAERIDQLMKAVDTWIPTPERDLDKPFLMSIEEVFSIPGRGTVASGRVERGLLKKDTEVEIVGGSEVPIKTKVTDIETFKKSCDESRAGDNSGLLLRGVKREDIRRGMVIALPASTKAAKKFLVSMYVLTEAEGGRRTGFGSNYRPQVYLRTADEPGDLTFPDGDESRRVQPGDNVEMVLETHRPVAAEAGQRFNIREGGRTVATGLITRVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZT4</accession>
    <name>A0A9X0BZT4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_003084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792646.1">
        <property type="nucleotide sequence ID" value="XM_056932687.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81622936"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058925">
        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="950"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5491517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1296" mass="141071" checksum="D774A3940B24314E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZZ7</accession>
    <name>A0A9X0BZZ7_9EURO</name>
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        <submittedName>
            <fullName evidence="8">Regulatory protein cys-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_001537</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
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        </lineage>
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    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793171.1">
        <property type="nucleotide sequence ID" value="XM_056931140.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81621389"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000075">
        <property type="entry name" value="BZIP transcription factor (MetR)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="175"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5492791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="284" mass="30915" checksum="A759A6C4A768736E" modified="2023-11-08" version="1">MPEEFLSFPSGPAVDKIENFNFLLSHANSAAKGARQYSLDTDLGLVPYSSLNMELDQTEGMGGLSVSSYDSIEDERNSLDLQAYPYQGPVGDKVIDYSVPDHIMPYPAHSVYPPMSFAPGDLGHATGALTPSDVSSSISPPNGQMGNIQYSTSIPGDRIAAALDQEGGVRVAAEEDRRRRNTAASARFRMKKKQREQVLERTVRETTEKNASLEARVAQLEMENRWLKNLLTEKHDIGPSRTPPPPSAPASSSKDSSSLESKANSTRPGQNHIQPKKKGVGTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0I7</accession>
    <name>A0A9X0C0I7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_001760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793394.1">
        <property type="nucleotide sequence ID" value="XM_056931363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0I7"/>
    <dbReference type="GeneID" id="81621612"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5493014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="122" mass="14039" checksum="20C7D8EB237808E4" modified="2023-11-08" version="1">MEISAYYSEPDSLDLYNQDLKTIHKWVGRRLVFRSLHIMIDRCPQIRAVPDRRMPGPSPKMIGSQEIDMQQSSQMCTVLDGFELIESCTVQEKIRPQFKSTVGICQDQRQIVARTSIHSGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2H5</accession>
    <name>A0A9X0C2H5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794489.1">
        <property type="nucleotide sequence ID" value="XM_056930196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2H5"/>
    <dbReference type="GeneID" id="81620445"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000500">
        <property type="term" value="C:RNA polymerase I upstream activating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039601">
        <property type="entry name" value="Rrn5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="72024" checksum="61EB8A0786477399" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2M4</accession>
    <name>A0A9X0C2M4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">lysine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_000919</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794816.1">
        <property type="nucleotide sequence ID" value="XM_056930523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2M4"/>
    <dbReference type="GeneID" id="81620772"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="224"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5495803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="421" mass="48725" checksum="0420077A6851322E" modified="2023-11-08" version="1">MADQNTVKEAEASMANLQLDSVTGEMVSKSELKKRLKLREREAKKKEKQYFEIRSKRVQKMFETKNPDPYPHKFQVTTDLRDFLKDYDSLKKGEEKPDVPIRLAGRVYTKRASGPKLIFYDLRAEGKKVQVMCQAQNATGSVPFEQQHEHLRRGDIIGVVGYPGRTSPKNRDDGELSIFATEVVLLAPCLHAIPSEHYGFQDKELRFRQRYLDLIMNDSTREVFRTRAKIISYIRNFLDNRDFTEVETPMMNQIAGGATAKPFVTHHNDLDQKMFVHVPWYMRIAPELYLKMLIVGGLERVYEMGRQFRNEGIDLTHNPEFTTCEFYWAYADYNDVMDLTEELVSGLVKHVTGGYETKFTTQSGEEYNINWKAPWRRIEMIPGLEEATGETFPPADQLHTAETGEFLKGVLKKMNVECTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2N3</accession>
    <name>A0A9X0C2N3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794669.1">
        <property type="nucleotide sequence ID" value="XM_056930376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2N3"/>
    <dbReference type="GeneID" id="81620625"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="313"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="541"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="673" mass="72839" checksum="6D1389C9C6A069B6" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2Y4</accession>
    <name>A0A9X0C2Y4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_000756</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794653.1">
        <property type="nucleotide sequence ID" value="XM_056930360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2Y4"/>
    <dbReference type="GeneID" id="81620609"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000882">
        <property type="entry name" value="Translation initiation regulator (Gcn20)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="199"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="531"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="123"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="282"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5495640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="751" mass="83426" checksum="9D168B3E0C0D4E18" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C355</accession>
    <name>A0A9X0C355_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794772.1">
        <property type="nucleotide sequence ID" value="XM_056930479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C355"/>
    <dbReference type="GeneID" id="81620728"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF16">
        <property type="entry name" value="DUF2235 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="28"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="662" mass="74484" checksum="19B6799BB758A94F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C378</accession>
    <name>A0A9X0C378_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein dopey</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_000965</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794862.1">
        <property type="nucleotide sequence ID" value="XM_056930569.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81620818"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056458">
        <property type="entry name" value="TPR_DOP1_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24597">
        <property type="entry name" value="TPR_DOP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="8">
        <location>
            <begin position="36"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like middle TPR" evidence="9">
        <location>
            <begin position="397"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="10">
        <location>
            <begin position="1374"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1052"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1074"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5495849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1864" mass="207513" checksum="B8224BA80E1669E9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKA1</accession>
    <name>A0A9W9WKA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785650.1">
        <property type="nucleotide sequence ID" value="XM_056939155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKA1"/>
    <dbReference type="GeneID" id="81629405"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF213">
        <property type="entry name" value="DEPENDENT OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="55"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5466604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="491" mass="54058" checksum="F53933EE8F6681E7" modified="2023-11-08" version="1">MGANNQRRMVHDRIVSLISQDPGLPRKGPSVAFWQEPTHPIANIQSAQLPTEVEIAIVGSGITGCSVARTLLENPKLRNKRIALFEARALTSGATGRNGGHLVSPSAVDFAAVASLFGADKAAEVTRFSFRNLERFHEFVSTLDPILQDAAEARKVQKVMNFLEPATFVHFKDSLLQFSNACPELADQFRILSADEAKAKYKFIDSAGACEQPAGAVWPYRIITGVLAKLMKEHASRFSIDTNTAVTAVTYEAGRPTHRRRVQTSRGVVYADQVVYCTNAYTSHLLPELRGKVFPFRGTMSTQSVTPSLPNHGARHSWSIYHEPRYDPATGTFTFGLYYMTQNAKTGDFFFGGEKQRLEEILISDDTVVPNLPAQNLVSIMENTFKSATGEAVKSTPRRIWSGIMGFTPDGMPLVGRLGKRLTGRPDDGEWAAVGFNGYGMDKCWLVGELLGAMIAGEDVTGQLPALYQITNERLDKLMAPRDVPARLFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKC9</accession>
    <name>A0A9W9WKC9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_009378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785695.1">
        <property type="nucleotide sequence ID" value="XM_056938973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKC9"/>
    <dbReference type="GeneID" id="81629223"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22997">
        <property type="entry name" value="GT_LH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587:SF2">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5466649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="523" mass="58995" checksum="61D23A3215900D8A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL37</accession>
    <name>A0A9W9WL37_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phospholipase D1</fullName>
            <ecNumber evidence="3">3.1.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Choline phosphatase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Phosphatidylcholine-hydrolyzing phospholipase D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_009087</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786059.1">
        <property type="nucleotide sequence ID" value="XM_056938682.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81628932"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01254">
        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000011">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="457"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="926"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="1232"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="338"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="550"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1327"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1379"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1447"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1611"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="92"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1337"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1398"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1467"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1611"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1623"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1697"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1711"/>
            <end position="1723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5469469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1813" mass="204320" checksum="26F7B652CD01B70D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL73</accession>
    <name>A0A9W9WL73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_009149</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 15"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786121.1">
        <property type="nucleotide sequence ID" value="XM_056938744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL73"/>
    <dbReference type="GeneID" id="81628994"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031502">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23283">
        <property type="entry name" value="beta-trefoil_MIR_PMT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000034">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="655"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="717"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="339"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="414"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="483"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="785"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="861"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="785"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="916"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5469531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="939" mass="104958" checksum="8A1CFC569A19E852" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLC1</accession>
    <name>A0A9W9WLC1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_009257</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nitroreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786229.1">
        <property type="nucleotide sequence ID" value="XM_056938852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLC1"/>
    <dbReference type="GeneID" id="81629102"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02140">
        <property type="entry name" value="Frm2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.109.10:FF:000001">
        <property type="entry name" value="Nitroreductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033877">
        <property type="entry name" value="Frm2/Hbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035:SF1">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="7">
        <location>
            <begin position="13"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5469639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="204" mass="23631" checksum="D0C7C24298B8C122" modified="2023-11-08" version="1">MADIARSIIQGMQNRRSIYSFTNESTISDDRIEELVSQTILHTPSPFNSQSARLVVLLKEQHERLWDLALEVATASVPPEQLENLYKPRTAMFRAGYGTILFYEDPAPLKPLEVKWPMLIDKFPEWSDHSSGMHQFALWTLLEAEGLGCNLQHYNPMIDARVSQEWKIPLEWRLKAQLVFGKPTGPPREKKFEPLEKRMFVHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WM55</accession>
    <name>A0A9W9WM55_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_009345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786317.1">
        <property type="nucleotide sequence ID" value="XM_056938940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WM55"/>
    <dbReference type="GeneID" id="81629190"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="816"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="816"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="510"/>
        </location>
    </feature>
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        <location>
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            <end position="818"/>
        </location>
    </feature>
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        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
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        <location>
            <begin position="588"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="704"/>
        </location>
    </feature>
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        <location>
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            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5469727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="896" mass="100583" checksum="667FE4A326F1219E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WR54</accession>
    <name>A0A9W9WR54_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A9W9WR54"/>
    <dbReference type="GeneID" id="81628478"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050977">
        <property type="entry name" value="Fungal_Meroterpenoid_Isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39598:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39598">
        <property type="entry name" value="AUSTINOL SYNTHESIS PROTEIN F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5472064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="155" mass="17446" checksum="60E51C28A4846568" modified="2023-11-08" version="1">MPTLYERCGDTALAFIGSFPGSVPEAIIAYRAKNCLHRIRSGSLSSGPMTNTEYRAWVKSLMPVMRNFQLHLQEGHLPIIDATQRKVTLYLRSTSDTDFGNYSNESIWILSLDDTGRKVNDIVEFTDSEYTSNWIPKLMEAAVLKGTNMVSQGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WT11</accession>
    <name>A0A9W9WT11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein ecm33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_008029</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5474963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786721.1">
        <property type="nucleotide sequence ID" value="XM_056937629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WT11"/>
    <dbReference type="GeneID" id="81627879"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051648">
        <property type="entry name" value="CWI-Assembly_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018:SF3">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12454">
        <property type="entry name" value="Ecm33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040748614" evidence="5">
        <location>
            <begin position="20"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5474963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="399" mass="41862" checksum="A0525F97F5F78DBC" modified="2023-11-08" version="1">MPFVKYILPALAASQLAFASSDPCGDAKVQNQGDADALASCGTIKGDITIAKSYTGTLSFSGFENVTGSITCDGGENITDITADKIIKIGKEFNLNGLTRLTTLAFGNLNNVGSISWNALPKLQSLNFNAGVTQAGDVMIQNTGLTSLDGISLKQVGMFQIQNNRDLMKININNLMNASDLINFSGNYDQLMIDLPNLGTGTNMTFRNISSISLPSLEKLTGQLGFWGTEFKTFSAPNLTTVGDVVFMDNSKLTNITMPVLTTVNGGFNIARNDKLSSINLPKLNRVTGAIDFSGKFNTVDLNGLNDVEGGFNLQSTDGNFSCNHFDNLRKNVIKGKYKCDAKTNKPTTSNGNSGTASSSGSSSSGSSSATSSGAAVANGASVAVTGVAAFFYAVAQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WT58</accession>
    <name>A0A9W9WT58_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 15">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="11 15">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">N7539_008122</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 15">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11 15"/>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786814.1">
        <property type="nucleotide sequence ID" value="XM_056937722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WT58"/>
    <dbReference type="GeneID" id="81627972"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14385">
        <property type="entry name" value="UBA1_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14386">
        <property type="entry name" value="UBA2_UBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000086">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000103">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000396">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000587">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF664">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11 15" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11 15" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 11 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="18">
        <location>
            <begin position="149"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="17">
        <location>
            <begin position="300"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="16">
        <location>
            <begin position="578"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="16">
        <location>
            <begin position="642"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="731"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ5475056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="777" mass="85805" checksum="5D1CDE82D2A1791F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTJ7</accession>
    <name>A0A9W9WTJ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787039.1">
        <property type="nucleotide sequence ID" value="XM_056937947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTJ7"/>
    <dbReference type="GeneID" id="81628197"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018465">
        <property type="entry name" value="Scm3/HJURP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15992">
        <property type="entry name" value="HOLLIDAY JUNCTION RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15992:SF5">
        <property type="entry name" value="HOLLIDAY JUNCTION RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10384">
        <property type="entry name" value="Scm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="666" mass="73802" checksum="A220FDA06EB5C98A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTR7</accession>
    <name>A0A9W9WTR7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mechanosensitive ion channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_008374</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787066.1">
        <property type="nucleotide sequence ID" value="XM_056937974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTR7"/>
    <dbReference type="GeneID" id="81628224"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000345">
        <property type="entry name" value="Mechanosensitive ion channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF15">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017209">
        <property type="entry name" value="Memb_At2g17000_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="501"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="445"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="727"/>
            <end position="793"/>
        </location>
    </feature>
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        <location>
            <begin position="841"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="764"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5475308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="935" mass="105196" checksum="AC3EB494B3987B26" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU73</accession>
    <name>A0A9W9WU73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787343.1">
        <property type="nucleotide sequence ID" value="XM_056937478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WU73"/>
    <dbReference type="GeneID" id="81627727"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031563">
        <property type="entry name" value="MOT1/MOT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970:SF9">
        <property type="entry name" value="MOLYBDATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16983">
        <property type="entry name" value="MFS_MOT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="45414" checksum="9F780A28507C94EE" modified="2023-11-08" version="1">MTVQTLREISRYNLSTFRRNYVSEISGSLGDLGTFLPIAIALTVNGSVSLASTLIFSGVYNILTGLFFGIPLPVQPMKAIAAVAIARNFSSGSIAAAGIFVGACLLIFSVTGLLRWFASVIPIPVIKGIQVGAGLSLIISACGGMLRPLGWVDPSWADNRIWAIVAFLALMITSVYGRVPYALVLFAIGLGFAIICTAGAGHLPVFSIWHPWLVVPTPHQWWVGAVDAGIGQIPLTTLNSVVAVVYLAGDLLPNVHTPSITHIGLSVAAMNLLGCWFGAMPVCHGSGGLAAQHRFGARSGASIVFLGVLKLVIGIMFGETLIDLLKRFPKAFLGVMVIAAGLELLSVGESLNTRGARDLGDSDPACSDEERKRRWTVMMVTVGVLVGFKNDALGFIAGMLCHWAYRVPEGWEMGRTRWSQGRLRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV33</accession>
    <name>A0A9W9WV33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_007368</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787768.1">
        <property type="nucleotide sequence ID" value="XM_056936969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV33"/>
    <dbReference type="GeneID" id="81627218"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052606">
        <property type="entry name" value="DnaJ_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040889780" description="J domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="43"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="243"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5477224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="395" mass="43984" checksum="ED8660C1C1AB677F" modified="2023-11-08" version="1">MKTALFSLFLLVFVGLAAAWSKEDYEIFRLRDELVTAEGANVTFYDFLEIRPNANQDQIIKAHRQKSRNLHPDKVRRTFIANYSKDKSKAKSANGVNVNKGPSKREVDAAVKAANARSARLNLVANVLKGPGRERYDHFLKNGFPLWKGTGYYYDRFRPGLGSVLLGLFLVFGGAAHYGALYLGWKRQREFVDRYIRHARRAAWGDELGVRGIPGVVSAPAPAPAPAPETPEGGAMAMNRRQKRMMDKENRKEKKTGRANGRGVTSSAPASGTSTPTEQPTSVGERKRVVAENGKVLIVDSIGNVFLEEQNEEGEKQEFLLDIEEIQRPSVRDTIVCKLPVWAYNKVVGRLFGSTETLEEEEEVSAAEAIVEDTAETTAKTKSSARRRGKRNQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVN6</accession>
    <name>A0A9W9WVN6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FMN hydroxy acid dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_007668</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788068.1">
        <property type="nucleotide sequence ID" value="XM_056937269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVN6"/>
    <dbReference type="GeneID" id="81627518"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000132">
        <property type="entry name" value="FMN dependent dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF75">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_4G07050)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 7" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="32"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="111"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="338"/>
            <end position="342"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="361"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5477524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="423" mass="47122" checksum="2702815DB9034C38" modified="2023-11-08" version="1">MSDPNNPNIQERTTPQWSLYRREAFWNTNHGQYPPFNTDPSEVEKLAKEKLSQGGWYYSACNAGMSWTHLANRQAFYRHRIIPRTLVDTNLRDTACEIFGHKVNAPIGFAPIGINRIYHPTGELSVAKVADELKLPYCLSSAGSYSIEDVGKANGGGPRFFQLYQSHDDELAISLMQRAWDSGFDACMLTTDTWSLGWRHNDVFTGNYAFYHDHGAGDIALQDPVFIKRLAEAGIDPKRNPKEAGAKWIDEHIWHGRAHTWEKVKWTMAQWKRISGGRPFCLKGILDVNAAKKCVEMGIDGIVVTNHAGRQVDGAIASLDALEKIVDAVGDKIYVMFDSGVRTAADAFKALALGAKFVFLGRLWVWGLGIAGEHGVRHVMKSFLAEFDLLMEEAGFQTIDQIDRTAIDSLPNSANLIATHAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1T7</accession>
    <name>A0A9W9X1T7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3(2)-5-bisphosphate nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_006788</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788324.1">
        <property type="nucleotide sequence ID" value="XM_056936389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1T7"/>
    <dbReference type="GeneID" id="81626638"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF2">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5480894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="353" mass="37931" checksum="FA000951D17A1D64" modified="2023-11-08" version="1">MSTPPYARELHLASLAVQRAALLTKRLLSEVDKGTFDKQDSSPVTIADFAAQASIIAAIHHTFPDDQIVGEEDSTALRENPALLERTWELATAVHLDDAASEALLHTPSSRDELLELIDLGAKGACGPGRVWTLDPVDGTATFIRNQQYVVCLSLVEDGTQRLGVLGCPNLKLDAGLVSEETVDRDGNGLLLTAIAGHGAFIAPLGKGALHESKPLERIPPVEKTSDIRFVDTQAASSHNLDAHARIAKQLDCPWPNTVDVWSAQMRYVAIAVQGGCNVFVKVPREKNYRSKIWDHAGGMLLVQELGCVVTDLEGEPVNCGLGRTLGGCYGMIVAPASIHSQLLDAVRAVRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1Y8</accession>
    <name>A0A9W9X1Y8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788378.1">
        <property type="nucleotide sequence ID" value="XM_056936443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1Y8"/>
    <dbReference type="GeneID" id="81626692"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5480948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="414" mass="46107" checksum="1A285092F9BA7258" modified="2023-11-08" version="1">MGSSASLMGLAPVTSPSGPRGLSESTSPKLMSIKDVHAEKPHRQFNSDGSIQLLPEFCQINIYAPDPTPEAEHMEFPPFEMPQPIWEPVLIPSQLVGKVKTDLASSRSSGYRLVVEKLGPGPEPEPELEPESTAQSSSLSPSGPSSLASALSTVSCSQQQQSLHGPDEQQHGDQPQPEESPTGSNPIPTFAKLVIDPPGPCPGQDVHIRPKVTFPFYDLVTDDEVIVSSVDVEFLETATDQIDRLRILIELLEKWGAAHALRLSTFRVQAQSWRRDRRLWELQMLQEVVSTRNLHMLHPGFTFQSLVAASRFAEQETRNDRRGAVEPWLLVMDEMEWNGLQAHTLRIRKTADTVKKGIYDLLSEDDKLLAKNRVLVKEVRLLEMEKWRASFSRTLSLSIPPFAHHAKKGDIELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X281</accession>
    <name>A0A9W9X281_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_006626</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788162.1">
        <property type="nucleotide sequence ID" value="XM_056936227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X281"/>
    <dbReference type="GeneID" id="81626476"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000561">
        <property type="entry name" value="Putative WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="364"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="407"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="520"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="562"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5480732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="626" mass="66636" checksum="2A9AAD0E6B613D2D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X285</accession>
    <name>A0A9W9X285_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyamine transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_006789</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788325.1">
        <property type="nucleotide sequence ID" value="XM_056936390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X285"/>
    <dbReference type="GeneID" id="81626639"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF182">
        <property type="entry name" value="POLYAMINE TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
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            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="234"/>
        </location>
    </feature>
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            <end position="309"/>
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    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
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        <location>
            <begin position="60"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5480895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="493" mass="53928" checksum="3B6480307B4B3796" modified="2023-11-08" version="1">MTHDGQHQENAILEDFVDKESTLAEEVPVVFAPDIQDVTLHWDQHPQDPLNLPARKKIILMVMVSLAAFITSAATSIVTPAQSAIQKAFNVSFTQSLLPLSLYTFALGSGPVIGGPVSETVGRMPVYYVAFPLGALFTLGAGLTSNFAALCFLRTAAGFCWAPMLTVAAGSIAETFSAKARGGMMALYILMPFLGPGFGPIFGAYAVSRHDWRWTQWVILFMTIPCLILIAFSPETFPPVLKRRIASRESDYDIPKSTLLANAHQFVTVTLSRPVHMLFTEPIVSFICLYTAINFGVLFCYFAAVPYMVGKVYSFSTEQAGLVFFSIVIGSTLGFITLVLCDIFFYRPKLGNLPPGQGSPEHRLYPAMIGSIGLPLGLFWFAWTSKSSISWASPVAAIVPYAWGNLCVFVSTAQYALETYHGNVLASVASAMSLARYVTAGAFPLFIMNMYQALHLDWAISLFGFVAVALVPIPFVLFKFGPRIRAKSKYETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X350</accession>
    <name>A0A9W9X350_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SigF-like NTF2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789044.1">
        <property type="nucleotide sequence ID" value="XM_056936120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X350"/>
    <dbReference type="GeneID" id="81626369"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057514">
        <property type="entry name" value="NTF2_SigF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35393">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35393:SF1">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24840">
        <property type="entry name" value="NTF2_SigF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="SigF-like NTF2-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5483072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="210" mass="24569" checksum="4D10FA8DDF228A7D" modified="2023-11-08" version="1">MERPVAEIRTVIQLLVQSPPSLQQKAIERFFVPDASFAHPFCRVPSFNGSRWWITKIFQWYKIMSPRIEMQVHSVAFDEDQLKLYVNMSQIFSIWLVPFHVAPVTLTTVLDLTTDRAQSDASTNGDHTKYYITRQEDLYQTSDFIKFLLPHIGYWLVMAWHLMATFFCLVGVTALWPMLYLEENGYLPVWISRGNLAYDIGEKLPEIKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3H6</accession>
    <name>A0A9W9X3H6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_006489</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789015.1">
        <property type="nucleotide sequence ID" value="XM_056936091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X3H6"/>
    <dbReference type="GeneID" id="81626340"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000027">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="226"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="516"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="741"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="850"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="591"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="690"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="535"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5483043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="905" mass="101361" checksum="3FFDA44FA62AE491" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3Q9</accession>
    <name>A0A9W9X3Q9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">N7539_006511</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789037.1">
        <property type="nucleotide sequence ID" value="XM_056936113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X3Q9"/>
    <dbReference type="GeneID" id="81626362"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000007">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0749">Sporulation</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 21" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="23">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="20">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAJ5483065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="158" mass="17989" checksum="FD7AE165F6D5F79A" modified="2023-11-08" version="1">MSTSARRRLMRDFKRMQTDPPAGVSASPVADNVMTWNAVIIGPADTPFEDGTFRLVMNFEEQYPNKPPGVKFISQMFHPNVYGTGELCLDILQNRWSPTYDVAAILTSIQRLVSHFCSLLNDPNTSSPANVEASNLYKDNRKEYIKRVRETVEKSWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X438</accession>
    <name>A0A9W9X438_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_006315</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the GAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788841.1">
        <property type="nucleotide sequence ID" value="XM_056935917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X438"/>
    <dbReference type="GeneID" id="81626166"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5482869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="210" mass="21260" checksum="77A1204136D22717" modified="2023-11-08" version="1">MSFRGRGTGANRGGFGSRGGRGGFQPSFGPPAQVLEMGTVMHACEGEMVCESINPKIPYFNAPIYLENKTPIGKVDEVLGPINQVYFTIKPQEGIVATSFKPGDKVYIGGDKLLPLEKFLPKPKPPPGAAKPKRAGGARGGRGGAPRGRGGFGGRGGAPVAVADSVLPVVGVVVVASVVVEVASLAVAVAASAVVAALVAASVVVVEVQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X4A1</accession>
    <name>A0A9W9X4A1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trehalose-6-phosphate synthase</fullName>
            <ecNumber evidence="6">2.4.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">UDP-glucose-glucosephosphate glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_006405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788931.1">
        <property type="nucleotide sequence ID" value="XM_056936007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X4A1"/>
    <dbReference type="GeneID" id="81626256"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000007">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000035">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012766">
        <property type="entry name" value="Trehalose_OtsA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02400">
        <property type="entry name" value="trehalose_OtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5482959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="508" mass="56992" checksum="243346BBAA538661" modified="2023-11-08" version="1">MSSAEDPKPNDARLLLVSNRLPITIKRSEDGKYDFSMSSGGLVSGLSGLSKSTTFQWYGWPGLEVPEAEIPTVTKRLKDEYGAVPVFIDDELADRHYNGFSNSILWPLFHYHPGEITFDESAWEAYKEANRLFAKAIAKEVRDGDLIWVHDYHLMLLPQMLREEIGDSKKNIKIGFFLHTPFPSSEIYRILPVRNELLLGVLHCDLIGFHTYDYTRHFLSSCSRLLGLATTPNGIEFQGKIITCGAFPIGIDPEKFAEGLKKEKVQKRIAMLEEKFKGVKLMVGVDRLDYIKGVPQKLHALEVFLSDHPEWVGKVVLVQVAVPSRQDVEEYQNLRAVVNELVGRINGKFGTVEFMPIHFLHKSVNFDELIALYAVSDACIVSSTRDGMNLVAYEYIATQRKRHGSLVLSEFAGAAQSLNGSIIVNPWNTEELAGAYQEAVTMSDEQRALNFAKLDKYVSKYTSAFWGQSFVTELTRISNQSTDKFQAQKLAVDASNSTNGSVTSEQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X4R7</accession>
    <name>A0A9W9X4R7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_006011</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000007">
        <property type="protein sequence ID" value="KAJ5483811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789081.1">
        <property type="nucleotide sequence ID" value="XM_056935613.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81625862"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000016">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="703"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1791"/>
            <end position="1867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1777"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1781"/>
            <end position="1796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5483811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="2749" mass="305845" checksum="9868B8290B584B0D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X4R8</accession>
    <name>A0A9W9X4R8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_005723</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789197.1">
        <property type="nucleotide sequence ID" value="XM_056935325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X4R8"/>
    <dbReference type="GeneID" id="81625574"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.80:FF:000001">
        <property type="entry name" value="ATP synthase gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039089">
        <property type="entry name" value="ATP_synthase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5483927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="297" mass="32279" checksum="29767DC7B3350C71" modified="2023-11-08" version="1">MFSRAVRPAVRAGSSAVARATPANAANFATLREIEGRLKSIKNIEKITNTMKIVASTRLTRAQKAMDESRNYGKTSNTVFEQAETKPVEDKKTLYVVASSDKGLCGGIHSGLSKATRRLLAQNPEADVVILGEKAKAQLSRASPQNIVMSFANVCKDIPTFADAQAIADQISLLPTDYASVKIIYNKFINAQSYEPTTVEAFSEEAITQSANISAYEIDDEALALLREYALANNLFWAMAEGHACEISARRNAMENASKNAGEMINKFQILYNRQRQAAITGELVEIITGATASADM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X4Z6</accession>
    <name>A0A9W9X4Z6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_005828</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789302.1">
        <property type="nucleotide sequence ID" value="XM_056935430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X4Z6"/>
    <dbReference type="GeneID" id="81625679"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF12">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="35"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="300"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="8">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5484032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="421" mass="44222" checksum="3D365BC1D57C6D67" modified="2023-11-08" version="1">MSSPQQRLSSITKQLSPAGVSAARANILAKNPDDVVITYLARTPLTKARKGGLKDTSVDNLLISLLTAVRENSKIEPSLVEDVSVGNCLAPGAAYLARSAVLAAGFPVTTAASVSNRFCSSGLLAVQNIANQIIAGSIDVGIAVGAESMSTNNDGGAPEMAERINKHPVASQNYMPMGQTSENVAAQFGITREQHDQFAAKSFQKAEHAQKAGWSQDEIIPIKTQVKDPKTGEVKDVVVDRDDGVRYGTTPESLSKVRAAFPQWQPSATTGGNASQITDGAAALLLMKRSQAQKLGQPIIGKFCGATVAGLEPRIMGIGPTLAIPKILKKFGLTKDDIDIFEINEAFASMGVYCVSKLGLDEAKVNPRGGAIALGHPLGATGARQVVTALSELRRRDQRVAVTSMCIGTGMGMAGIFVSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X532</accession>
    <name>A0A9W9X532_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 8 central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_005717</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789191.1">
        <property type="nucleotide sequence ID" value="XM_056935319.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81625568"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059070">
        <property type="entry name" value="TPR_VPS8_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25066">
        <property type="entry name" value="TPR_VPS8_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 8 central" evidence="2">
        <location>
            <begin position="700"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="domain" description="VPS8-like TPR-like repeats" evidence="3">
        <location>
            <begin position="1224"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1468"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1468"/>
            <end position="1479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5483921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1567" mass="173850" checksum="0D26E8669C61B6A5" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5C8</accession>
    <name>A0A9W9X5C8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_004701</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789497.1">
        <property type="nucleotide sequence ID" value="XM_056934303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5C8"/>
    <dbReference type="GeneID" id="81624552"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF55">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5484713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="56193" checksum="D46D5EE9005E5A5D" modified="2023-11-08" version="1">MIHLHRPRGHDATKELSEKDAARTVVSDVAQDIDPVIEKRVLKKIDWYFMPAMLIGYGMVYYDKAILGSAALFGMTTDLSLMVVDRSTSPPTVDTSRLSWATSIFYFGMLAGLYPMTFMLQRFNMRSVLGPVVLVWAIVCAATAGVASWRGLFVQRFFLGFIESVIPTGFISIVSGYYTQEEQALRQAWWFSGTGWFTIIGGALNYGFGQITSGSLARWQYIYILAGALTFVFGLWCCTLPNSPVSASFLTPEQRIVAVERLRKGQTGVRCQKIKWDQIRESLTDVKFYLVAVMMASAYTINGAIAGFGPLIVSTFGYNTLESILFQFPVGAICVIFIPLCGYIPTIVPNTRIPMLIACCLPVIAGCIMIWKSEWNHRPVVPVVGYALTGFFGPVVSLIITIGASNVAGATKKSIMAATIFVAYTVGNIIGPQLIRSETKARHYPELWTAMIICYCIVIATAGILYALLRRENHARDSVNLDEVQRDKIAFDDLTDKQNPFFRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5E1</accession>
    <name>A0A9W9X5E1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carbon catabolite repressor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">N7539_005882</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC-rich region in their promoter. Also plays a role in response to carbon starvation and the control of extracellular proteases activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with creB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the creA/MIG C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789356.1">
        <property type="nucleotide sequence ID" value="XM_056935484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5E1"/>
    <dbReference type="GeneID" id="81625733"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043609">
        <property type="term" value="P:regulation of carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000089">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000152">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="259"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="338"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ5484086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="416" mass="44742" checksum="1F4C33E88CAA0F40" modified="2023-11-08" version="1">MSPSTSVGFSNLLNPQEATTTSPVVAAPPTTTLASESSMASSVSLLPPLMKGARPANEEVRQDLPRPYKCPLCDRAFHRLEHQTRHIRTHTGEKPHACQFPGCTKRFSRSDELTRHSRIHNNPNSRRSNKAQHLAAAAAAAAAGQDAAMVTAANMMPPPSKPITRSAPVSQIGSPDVSPPQSFSNYANHMRSNLGPYSRTSERASSGMDINLLATAASQVERDDHLGFHGSRHNMFGSRHHARGLPSLSAYAISHNMTRSHSNEDDDAYGHRVKRSRPNSPNSTAPSSPTFSHDSLSPTPDHTPLATPAHSPRLRPLGASELHLPSIRHLSLQHTPALAPMEPQPEGPTYYSPGQGHMGPSISDIMSKPDGTQRKLPVPQVPKVAVQDMLNPSTGFSSMSSSTNNSVAGNDLADRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X663</accession>
    <name>A0A9W9X663_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">U-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_005021</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789817.1">
        <property type="nucleotide sequence ID" value="XM_056934623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X663"/>
    <dbReference type="GeneID" id="81624872"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16657">
        <property type="entry name" value="RING-Ubox_UBE4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="13">
        <location>
            <begin position="990"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="815"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="815"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5485033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1077" mass="122251" checksum="64A084B1303F329C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6F8</accession>
    <name>A0A9W9X6F8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino-acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_005186</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789982.1">
        <property type="nucleotide sequence ID" value="XM_056934788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6F8"/>
    <dbReference type="GeneID" id="81625037"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF29">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5485198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="592" mass="63818" checksum="FD8C1B505FB2DD78" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6N2</accession>
    <name>A0A9W9X6N2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_005306</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790102.1">
        <property type="nucleotide sequence ID" value="XM_056934908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6N2"/>
    <dbReference type="GeneID" id="81625157"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="226"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="228"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="293"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5485318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="321" mass="36318" checksum="95259346517E0DCF" modified="2023-11-08" version="1">MSQPRALYEDNDMAISYTNRVPAGHPPTLPSFRELLPPHLHDEIDSSVALYNNRPQSQDRPASVHEAAIDPRSMPNFSPTTSLKKRYGEHTLQYTTRSDERLPRPVSDHYPLRFSDHAPRGPSPILPPLRDFQSMNDRKGLPEESPTVSRSEPFAQDFRAAQSVSLPGPVGDRRHPDPYTDTLLNNQPPFPPSAALYPGDSDQMSPNMLAHSQQANFGIMGDSIDPKTKRRRGNLPKPVTDILRAWFHEHLDHPYPSEEDKQMFMTRTGLSISQISNWFINARRRQLPALRNQMRTGGGEAESSRHSPFSDVEQEPLPSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6S6</accession>
    <name>A0A9W9X6S6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_005182</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasmic vesicle</location>
            <location evidence="1 13">COPI-coated vesicle membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="13">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789978.1">
        <property type="nucleotide sequence ID" value="XM_056934784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6S6"/>
    <dbReference type="GeneID" id="81625033"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000016">
        <property type="entry name" value="Coatomer alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="5 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="176"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="264"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="16">
        <location>
            <begin position="358"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="17">
        <location>
            <begin position="633"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="858"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="896"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5485194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="914" mass="101291" checksum="F23EBA72E22C76FF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X841</accession>
    <name>A0A9W9X841_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Quinate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_005413</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Integral membrane transporter that imports quinic acid to be catabolized as a carbon source.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with creB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790209.1">
        <property type="nucleotide sequence ID" value="XM_056935015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X841"/>
    <dbReference type="GeneID" id="81625264"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="14">
        <location>
            <begin position="15"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5485425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="511" mass="55817" checksum="8AD92D0B656A5956" modified="2023-11-08" version="1">MPTTTTSHAMRVYILAIVTSMGAFMFGYDLAFIGTSIELKPFKRDFGLLGASQSAQNAFAANVVSLLQAGCFFGSLAAAPVGDKFGRRIALATGAVCFIAGSVMQVASSGSQTVMFVGRLVGGLGVGAASMLVPLYTAECAPPEIRGRLVGIYEIGVQLGTCLGFWINFGVEQHMAPTSAQWMTPFALQLIPGGLLLIGLWFMPESPRWMAKAYGRSRVIEVLSLLRSLPVDHPDLQHEADDIFQQLELERAVSPDGALSSVKELMQPGIRYRVFLGVVIMIFFQMAGSNAINYYSPRIFKSIGLTGTKATLVSTGIYGIVRVVAVFFAMYFVVDRFGRKPMLIFGSAVMAISMWLTGAFVKIQETDVKTGSSMSGTSYAAAVFIYVFAVAFCFSWAGVPWIICSEIYPLRVRGLAVSVCVATHWLFNFVLARSVPYMISNITFGTYFFFAACTTLSIPFVWFMIPETKGLSLEEVDTVFEDRIFSLRPRTSSFRQDAPEQKAAVEQIETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XC12</accession>
    <name>A0A9W9XC12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD synthase</fullName>
            <ecNumber evidence="2">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_003382</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790525.1">
        <property type="nucleotide sequence ID" value="XM_056932984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XC12"/>
    <dbReference type="GeneID" id="81623233"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="14">
        <location>
            <begin position="140"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5488492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="376" mass="40477" checksum="2CEEED62BF62E7EA" modified="2023-11-08" version="1">MAQSVGTQSGSAASPLSTHASTSASDHLRPFRPVTTTPREQLPRGVDSAAAASPDQGSGLSATSIAQDRDSSVPESTSAEKDGNDVPPLPVVVAQIHARVQSFLDESHPPSSLLASVQRQTRMSLDVVAKALTKYKFSELSISYNGGKDCLVMLILFLAGLHPHLSATQSGPDSTTPQSIPATTPSTSTPSTSDQSEGSSETISEIPAIYALPPDPFDAVEDFVITSAQAYHLQVTKYTTAPPATTMRSCFEDYLAGHPGIRAIFVGTRRTDPHGGKLTHFDQTDHGWPDFMRIHPVIDWHYAEIWAFIRHLGLTYCSLYDMGYTSLGGTSDTHPNPRLRKVSETGSLSGGHTDAQTEYLPAYELTQDLEERLGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCC7</accession>
    <name>A0A9W9XCC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phospholipase D</fullName>
            <ecNumber evidence="1">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003579</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790722.1">
        <property type="nucleotide sequence ID" value="XM_056933181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCC7"/>
    <dbReference type="GeneID" id="81623430"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000032">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000034">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF186">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="975"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="434"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="436"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="508"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="533"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="633"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="650"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5488689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1210" mass="133673" checksum="4A80B1A74D1ACDB9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCF0</accession>
    <name>A0A9W9XCF0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790769.1">
        <property type="nucleotide sequence ID" value="XM_056933228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCF0"/>
    <dbReference type="GeneID" id="81623477"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5488736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="106" mass="12521" checksum="47C9DAFB5A9488B6" modified="2023-11-08" version="1">MISPEQRRRIVNRVIFQYPFDERPGLWIYLLWFCLSTRTNNRTQPDFIATEIETGYSSDFIQQGFQELSDYGRTVHAAIQSAVEELEHVNRLSNRLSPIEEDPNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCQ8</accession>
    <name>A0A9W9XCQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790809.1">
        <property type="nucleotide sequence ID" value="XM_056933268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCQ8"/>
    <dbReference type="GeneID" id="81623517"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="149" mass="16827" checksum="9429BB0DD787FBC7" modified="2023-11-08" version="1">MMHHMVTRHGYWLKIGNFVTCESGICIRRLVGARAREVSGTSGFAHPGRIEGQESTLKAPGLFLEGVLQLASLWMEELGLLRVAAIGRLDTERIWPCVPEPSRHDRGSTSKAASEPSETRADDDDEEEEEEEEEKEEPQQLGWRNCRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCS4</accession>
    <name>A0A9W9XCS4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_003418</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790561.1">
        <property type="nucleotide sequence ID" value="XM_056933020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCS4"/>
    <dbReference type="GeneID" id="81623269"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000201">
        <property type="entry name" value="Salicylate hydroxylase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF172">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="7"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5488528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="447" mass="49715" checksum="5617AD43920A4886" modified="2023-11-08" version="1">MSGWRELSVGVIGGGIGGMSVAIALRRAGHVVTIYEKSDFAGEVGASVSCAANGTRWLYEWGVDVAKGDPVVLKKLINRDWKTGEPVSVYDLNDYEQRWGYAYNMFHRQYMHSMLKDTALGEDGEGIPAKLMVNHRCCDIDMESHTITFENGDQVKHDLIVGADGIGSAVRRILGIKPEKRPSEQSCLHANVDTEEAVRLGLVDYSKNSALEYWGGQEGKWDKIVLSPCNGGKLLSYYCFFPRAVGDYTSQAWGVESRPVEELLSPYPELDSQVLKHLSIGKEIQPWRLWVHDPYPYLQKGSVCLLGDAGHPMMPHQSQGACMAIEDAAALGILFNRKYFNGDIRQSLEAYEKVRLPRVTRVQASAAKAAYNINERIGFSVNKNIPTYKVEDPKKVLTIEEMNAYDMYHDIDEKLAHIRGVKYEDPYICGLPYGLELPSGVVIGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XD64</accession>
    <name>A0A9W9XD64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="13">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 13">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_003936</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791079.1">
        <property type="nucleotide sequence ID" value="XM_056933538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XD64"/>
    <dbReference type="GeneID" id="81623787"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000018">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 15" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="38"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5489046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="117" mass="13262" checksum="070DC2B6DB433DE5" modified="2023-11-08" version="1">MAAAPDPKIQDLLNKPKSELTEFEVGLVEEHELNAGPLSLLQTATRTHTQVLISCRNNRKLLARVKAFDRHCNMVLEHVKEMWTEKPKGNKGRGVNKERFVSKMFLRGDSVILVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDG9</accession>
    <name>A0A9W9XDG9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003908</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791051.1">
        <property type="nucleotide sequence ID" value="XM_056933510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDG9"/>
    <dbReference type="GeneID" id="81623759"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="15"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="347"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="390"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5489018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="421" mass="46240" checksum="70E8473CC0A6BBF5" modified="2023-11-08" version="1">MPGDDLKAHAASNQDFYALLDLSPAANESEIRRAYRRTALKYHPDKIANPTDADIDKFHLLQIANDVLSDPAIRQLYDNAREARMRKQRERDQMDAAKRKMREDLEARERAGTATAQQGVKRSWGVPGGEEDAEAKLQREIERIAEDGRRRRREATDKMKRDLEEEQRKLQAEEEEARKAADRSSQRVDRSRDGGTNVPELERSVKVRWVREGQGADWDAESLKSLCAPFGAIDGAFVMKDKRARVEGKKGKVTYGLGVVVFKSIVSTQAAVLDGEKKILRKEGDWALVDSVTYSSGAAPDLGFSTAGQPEVSTAKTTTDATNEPFKTSAKPAFSFAGLKPGVPSSGKAPSFGSFPTAGGNAPKASSFNPSAASSTPSLQEITMMRLKNAQREKERKALEEQLVREDKAADAAEEAKSAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDK9</accession>
    <name>A0A9W9XDK9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_003968</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791111.1">
        <property type="nucleotide sequence ID" value="XM_056933570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDK9"/>
    <dbReference type="GeneID" id="81623819"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.60:FF:000005">
        <property type="entry name" value="DNA polymerase alpha subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.60:FF:000008">
        <property type="entry name" value="DNA polymerase alpha subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018300">
        <property type="entry name" value="DNA_pol_alph_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="9">
        <location>
            <begin position="224"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="8">
        <location>
            <begin position="363"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5489078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="655" mass="71750" checksum="068E7B795B895E10" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDU5</accession>
    <name>A0A9W9XDU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Amino-acid transporter arg-13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_004445</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791588.1">
        <property type="nucleotide sequence ID" value="XM_056934047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDU5"/>
    <dbReference type="GeneID" id="81624296"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000109">
        <property type="entry name" value="Ornithine carrier protein AmcA/Ort1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="55"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="155"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="261"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5489555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="354" mass="38096" checksum="5584AB531306288E" modified="2023-11-08" version="1">MAAAEHAIPIRDEAVAMELPSLPPNQGLEAMKDIAFGSVSVSFCLVLTGASAVPGPNLFVANDFQVAGMAGKTIEYPFDTVKVRLQSQPDHLPLRYTGPVDCFRQSFQAEGIRGLYRGISAPMFGAAVETSCLFFSYRVIQDAIRAAFFPGVDKLHFMVLVASGALSGSVTSLALTPIELIKCKIQVPLDSARYHKPIGPLGMIVRVFREEGIRGFWRGQMGTLIRETGGSAAWFGGYEGATSLLRKYSQPPGSSESTESLPVHQQMLAGASAGISYNFLFYPADTIKSRMQTADVSLLAATGERQTFIGVGRAIWSQQGLKGLYRGCGITCARSAPSSAFIFSVYEGLRSYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE94</accession>
    <name>A0A9W9XE94_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791774.1">
        <property type="nucleotide sequence ID" value="XM_056934233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XE94"/>
    <dbReference type="GeneID" id="81624482"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
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        <location>
            <begin position="101"/>
            <end position="380"/>
        </location>
    </feature>
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            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
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        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
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            <end position="233"/>
        </location>
    </feature>
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            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="380" mass="43898" checksum="25E94A818ABB75A3" modified="2023-11-08" version="1">MKGNVMITLLISIPFSIVFIGALVLFWYRHHITNNVTRHRVRLQLFRHISRERLQNQDVERGGLYYGPPMPRYTSHGWMRPSRRHYGEPVELEYLNRHRTCRDPSRHRAQDCRRAGAPHSSSSAEQGRGKPVKTGQKKGKPVKTGQKKGKASQDNNKQNNKNEGREPPRNRKKKKKNQKADNDDGNKDKDTNNENTQNSSQQEQQEQTKKNNNNRRQNQTRDEPSKKKQKDQGAETSWGNQSQNNDDQDQPQNANQQQDQADIKESRRQNRGQNKSTRQNCEKRASEEGWGNHSQNDDNHGQSHNENGGWGADENEDWKGQNNHDQDQSQNDNWGTADNQQPEKAPEKEDWDGNGSEQGSWGQQAERNEAMDNAKNNDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE97</accession>
    <name>A0A9W9XE97_9EURO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">N7539_004521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422:SF1">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="92"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="142" mass="15520" checksum="7F7A2EC6EDF6E976" modified="2023-11-08" version="1">MSTSDRPISPTVFAEAIKELPLESLHAEAVKLTNDIAKLLESNAALEAEKAVETEDGIKFLDDVIVENEGVVKWKEERIELLKREVEDRGQIWIDPKKAGQEDGDEEQPSVVNGTRHGGDEAGAGGNVQQRQAPDGDEGVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9W9XF43_9EURO</name>
    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5490966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="243" mass="27548" checksum="63367ECA0101CCDB" modified="2023-11-08" version="1">MSRLADYRLLCFDVYGTLIDWETGLLAALQPLLTNKGSHDDDTFSRAHLLAIYQELESEQQRLTPDMPYPDLLATIHPQLAARLDLPAPSETDNQRFGESIGTWPAFPDTVDALHRLSQHFKLVVLSNVDRASFARSNAGSLRGFRFDRIITAQDVGSYKPDLRNFEYMKVTVEREFGVKAGEILQTAQSQFHDHRPAREVGIRSVWIERPGATMGNCSTEEAIFDWRFETLGDMADALTRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9W9XFJ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C6 transcription factor</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">N7539_002868</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="2819901"/>
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            <strain evidence="2">IBT 30728</strain>
        </source>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="103"/>
        </location>
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        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28175" checksum="4A439C5B6CA08CD8" modified="2023-11-08" version="1">MLESHHALVVKALQKLYKFCINKEGFPGEPLAEAPDGHPLTHTILDRLGLIKQAEENADEVDEDSEDLRYLRILSTSTECSVTAEPSPEPTTPTEPSPTTSSRASVCQGILTPMTSRNNSTWQWDMQATQQTNLSYPGNGFPGFFAPARPSIGSADSSSGDVFSHIDNSSPSILSHHPPRHDQQLLTYFLDPASNIASSSSIESKSVDRYNQGFHISETHSHAAATLPGDVWTDFNFPTHDQALYETFTPSWSFPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG86</accession>
    <name>A0A9W9XG86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792777.1">
        <property type="nucleotide sequence ID" value="XM_056932818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG86"/>
    <dbReference type="GeneID" id="81623067"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5491649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="98" mass="10929" checksum="14DCE7069B6CAB35" modified="2023-11-08" version="1">MPTLWSWMAMNLSKNVFKVFFIEQGTDRTFGLAMLHRHFDLEPGGMLVDYEGTSVPWNESHVSEMNPLEPAIWAISSDGDIKPTGFCFSAGNGLTMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGF1</accession>
    <name>A0A9W9XGF1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_003269</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792830.1">
        <property type="nucleotide sequence ID" value="XM_056932871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGF1"/>
    <dbReference type="GeneID" id="81623120"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5491702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="249" mass="28941" checksum="191A0352BC087870" modified="2023-11-08" version="1">MADAWGNNGQMGQLGQFPLEQWFYEMPPVTRWWTVATVATSVLVHCNIVNELQLFYSFRAVYAKSQYWRLFTTFLYFGRLDLDLIFHVFFLQRYSRLVEESSGRSPARFAWLIFYATSLLLIISPFLSLPYLGSALSSCLVYIWARRNPDTRLSFLGLMVFPAPYLPWVLMAFSLLLHKIVPKDEMLGVAVGHVWYFFNDVYPPLHGGHRPLDPPSWWRRLFETQSTRAQGRPVDNHREGHDVPAAIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGH6</accession>
    <name>A0A9W9XGH6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792947.1">
        <property type="nucleotide sequence ID" value="XM_056930916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGH6"/>
    <dbReference type="GeneID" id="81621165"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5492567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="237" mass="27575" checksum="2209B2A5AA4E324A" modified="2023-11-08" version="1">MTKRSMQFESPERAAKRPSPETWSVPARMVQSAPAIPTSKLILFAGQTEPARHQNPVRAAKKAMIIQAASMKLYAAEDVVANERGIEFFREMKETKKELREMREMMESQKNFNKRVEEDIIRLQKRFLQERRRIISTFVRDSKFPQNQVERRMVLNAPENKELKASMELIRELNQKTHGGNIHEDARMALAFFEPSNEEYKAIETLYQMTPQEITLLGKHEDPFKGLCQNPPLTRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGL2</accession>
    <name>A0A9W9XGL2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_002809</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792371.1">
        <property type="nucleotide sequence ID" value="XM_056932412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGL2"/>
    <dbReference type="GeneID" id="81622661"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="6">
        <location>
            <begin position="39"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="5">
        <location>
            <begin position="188"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5491242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="37691" checksum="D8199AC751B2B5CE" modified="2023-11-08" version="1">MECKRDDRSPISTVGIEFPFFKGSKNGGLVEATGHLDLGPTQVSVTITHCGVCGTDEHFRRVDQGLSHEGTGTIVELGSSVHVISDFQVGDRVGMGWFHRFCGYCNFCGQTGRQTLCVNRSSYGSADQDQGCFGSALAWDISALYKIPESIASEDAGPLVCGGATVWTPLYDSGVKPGARVGVIGIGGLGHMAIQFASKMGLEVVVFSNTESKKQEALGFGASELHATQSRESLKGVKPIDIFMITTSVNPKMSLYYPILVHAAKVYPLTVSMENRDGVSPMNLINDSFVIVDSGVAATASIRVMLEFAARHKVRPQIEKFPMTVTGINDAMQKLRDGKMRYRGVLVAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGR4</accession>
    <name>A0A9W9XGR4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793072.1">
        <property type="nucleotide sequence ID" value="XM_056931041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGR4"/>
    <dbReference type="GeneID" id="81621290"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="433" mass="49263" checksum="14A2BB103B58006B" modified="2023-11-08" version="1">MVQGKIHHKSSSRSGQRESKCLTNSEVVQILRSLPGDRPFGVLEEGETSEFLRQLYIPLRSLFSTTTTTSQANRARIEQIDHLEVPSRLRSRFSSYETDPLEFWERLVNPLPQYSDQLRENRAPVFLQGAAQLDSNIEEQRILRRFVAVSAYNLFRRTFPTSSHTRVLEKQLEQFLFMAELPVSEHKICGDIIRRGQRHTQFCQKLKVGEEAGFGALFFASIPDTIWDDGGLHGEDFEQSIKHLQQKKIIEESVKSNANRVANTLLRFHTNYVWTPRTCREGRHSRHREPGFVGIDTNFPVQLASETPITDLGEMSTLAQRGEIETNANEDGSQFEQLVTATCSANSLESPQECPSVATSHESFGPQLDMTYLDFFGPQLDMAYLNFFGQQLDMAEFDCVDVQPSIDSLESDEFGSNHLWQSSNCRSANETLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH16</accession>
    <name>A0A9W9XH16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_001619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793253.1">
        <property type="nucleotide sequence ID" value="XM_056931222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH16"/>
    <dbReference type="GeneID" id="81621471"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025204">
        <property type="entry name" value="CENP-L"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13092">
        <property type="entry name" value="CENP-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5492873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="352" mass="38264" checksum="A0D5B4FD98872D23" modified="2023-11-08" version="1">MESASQGQLFNTSWTLHRLSPLYHGEDSVSLLSNAAALKAYATRLRDQLTGDVLAGLHIPTSATADETLSRTGALLDCRWETLEPSSTRPNASFSGLLVTLEYENISCKAALLASPDDNDATNSTSRAKRSGVTMLPLLLTRFPTALRQTFISFLQSNFDAYCSNLRLSSAFLCTGLETFITELRGSRDHSNADNAVEETVRDLQLSLAFSSSITPALRNLNVNIARDSLVGFLNSDSTSETSRRKSPTQRQPKSKLIANISAYLDTHLAMQVDLDGSLQNTVSRQHVRLSKVACAAFVLGSEGRMKLVVNATQTSGNEDDAEQRVPPSLRASEMLLRSIIEKAAMADLSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH68</accession>
    <name>A0A9W9XH68_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_001662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793296.1">
        <property type="nucleotide sequence ID" value="XM_056931265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH68"/>
    <dbReference type="GeneID" id="81621514"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5492916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="142" mass="15967" checksum="8B6767B438C0D62B" modified="2023-11-08" version="1">MQPPQTPQAPSSDSTNTSAVQYRCFVIIPLADESIRLYQTNHHLAFLLSTIRDTVDNEYPYVDIVGGECFLPPQTISITVSSPGRLDPVLDREAILNHASQVIAAWLEQYIRRGEIVPALRRIVDEILRMTGSRGQRGDLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH90</accession>
    <name>A0A9W9XH90_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">pH-response transcription factor pacC/RIM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_001584</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including pacC itself) and represses transcription of acid-expressed genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793218.1">
        <property type="nucleotide sequence ID" value="XM_056931187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH90"/>
    <dbReference type="GeneID" id="81621436"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000458">
        <property type="entry name" value="pH-response transcription factor pacC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001875">
        <property type="entry name" value="pH-response transcription factor pacC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050806">
        <property type="entry name" value="pacC/RIM101"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257:SF1">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC_RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="369"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="578"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="487"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="637"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5492838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="650" mass="69280" checksum="2DD8FC178BAAFDFC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHE1</accession>
    <name>A0A9W9XHE1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">allantoinase</fullName>
            <ecNumber evidence="6">3.5.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_001787</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-allantoin + H2O = allantoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17029"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15678"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="EC" id="3.5.2.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.5" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793421.1">
        <property type="nucleotide sequence ID" value="XM_056931390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHE1"/>
    <dbReference type="GeneID" id="81621639"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000032">
        <property type="entry name" value="Allantoinase Dal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017593">
        <property type="entry name" value="Allantoinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="10">
        <location>
            <begin position="63"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5493041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="510" mass="54607" checksum="B7204AD10B25DF50" modified="2023-11-08" version="1">MAAPTIPMIAVVASSRAVISGRLTSATIIISRTTGKITAVIDSVIPASEFPEGVPYTDYSPYVLLPGLVDAHVHLNEPGRTEWEGFYTGTQAAAFGGVTTVIDMPLNAIPPTTTVANFKEKLAAAQGKCWVDVGFYGGIIPGNAGDLKGLVEAGVRGFKGFLIDSGVDEFPAVSQKDIALAMAELADQPTTLMFHAEMIPPITASVGDTSQTSEPPSAPAGPLEAYSTFLASRPSAFETCAIGEILSLAHLAPNLQLHIVHLSAMEGIPLLREARAKGIKITAETCFHYLSLAAEQIRDGDTRHKCCPPIRSQLNQDGLWTELEKHANDGVIQTVVSDHSPCTPNLKLLPAHVPGHCAPEGDAKVAEHTGNFFSAWGGISSVGMGLPILWTELSRRKGLTPSPNDENTRNALQDIVRLCCANTAAQVGLQSHKGDLAVGFDADICVFDDSAEWVVEPSTMLFRNKCSPYQGRTMRGMVRETWLRGERIFTREAGFVESKPSGKLLLEKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHW5</accession>
    <name>A0A9W9XHW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793657.1">
        <property type="nucleotide sequence ID" value="XM_056931626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHW5"/>
    <dbReference type="GeneID" id="81621875"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="491" mass="55079" checksum="C258E4EF4284FAE2" modified="2023-11-08" version="1">MPSLLAAGHGLPPTPPHVNNGGRLDEPTFYPVGHTAFPPRYHQSGSEFIEQYSQSLIYSKPHAMGVYPGSGHAMHGVRDMHSMGHQQPMYGPAATSLPPIRANMQLPPMDNAISSQYRRHDMASTHQHAHQHQHQQHPSQRQQQQSRKEEKATGGVAAHLDYEMDRMSDFVAEMTQGMYDLYNTKITLSDIDFARSISPGTSVPPQFRKYVYQILSSTRLPSSTILLGLFYMSSRMRILSAQRTFHSSSGQIYRMLTVALLLGSKFLDDNTFQNKSWAEVSNIPVAELNKMELEWLFAFDWKIHDRIYDQQDGFASWRRHWDSWSAKANARAHESTRQTLAPLDTNVARHHQTVSKPLMSPEGPIPPQYQRGSHTESSWLNPAASEYSPPSAPHSGPNTPDYYPAGPWGFANPPPPYSQGTWIPPPPRYLPQSAPRSQPPSYHHTPAYGLPFAQSVWTGHGSSCGCVYCAKHMEFYMPHGAFPPLHPVIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHY7</accession>
    <name>A0A9W9XHY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">26S proteasome regulatory subunit rpn11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_001455</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793089.1">
        <property type="nucleotide sequence ID" value="XM_056931058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHY7"/>
    <dbReference type="GeneID" id="81621307"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="35"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5492709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="335" mass="37364" checksum="22152F2DB2CC4C3F" modified="2023-11-08" version="1">MDRINRMLQAAQGLGMGGGAPGGDTPNLIDNSETVHISSLALLKMLRHGRAGVPMEVMGLMLGEFVDEYTVRVVDVFAMPQSGTGVSVEAVDPVFQTKMMEMLKQTGRPETVVGWYHSHPGFGCWLSSVDINTQQSFEQLTPRAVAVVVDPIQSVKGKVVIDAFRLIQPQTVVMGQEPRQTTSNLGHLNKPSIQALIHGLNRHYYSIAINYRKTGLEENMLMNLHKHVWTEALQMKDFHEEGEHNVEQMKQLVSLAEGYEKRVKEETELTKEQLKTRYVGKVDPKKHIEDVSQKLIEDNIVAVSRQMIDKEASVARQSASKDTGNGTSMDLDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIA2</accession>
    <name>A0A9W9XIA2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793789.1">
        <property type="nucleotide sequence ID" value="XM_056931758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIA2"/>
    <dbReference type="GeneID" id="81622007"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="299" mass="33089" checksum="DD389C4C2B4C6B14" modified="2023-11-08" version="1">MRIDNLEDVIISILAAHPTLRVSSHTRLYGRSPMAQMYGRGAKHDTMEWKFRAWRREAQKLRATGGESTFQQQPTGRKKTRKASAATKGLSSSGKPSKSRREKLRADSDKEEYVPSTASLDFESDTSENDSLLNEPTVNNERITRRTRTRKMAIKFQSVTDSDIDDEIFLLGTYPCKKVRFTPNAKQEGECEMAPISRFSKYKSPPPVTESATTDTDSHGTASMCDASANNSDGDSDSDIDSDSDGDSDDVSGTDYGISGSSRAIKKRSTNAAVDADAHSGDNSSFFWHGPYWRSINDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIL1</accession>
    <name>A0A9W9XIL1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase family domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793655.1">
        <property type="nucleotide sequence ID" value="XM_056931624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIL1"/>
    <dbReference type="GeneID" id="81621873"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052765">
        <property type="entry name" value="PGM-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46192">
        <property type="entry name" value="BROAD-RANGE ACID PHOSPHATASE DET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="68527" checksum="B756E8E6E03E13B3" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIQ5</accession>
    <name>A0A9W9XIQ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_002096</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793730.1">
        <property type="nucleotide sequence ID" value="XM_056931699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIQ5"/>
    <dbReference type="GeneID" id="81621948"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046951">
        <property type="term" value="P:ketone body biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07938">
        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000201">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000138">
        <property type="entry name" value="HMG_CoA_lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004283">
        <property type="entry name" value="PRK05692.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF17">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01062">
        <property type="entry name" value="HMG_COA_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="362"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5493350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="419" mass="44837" checksum="3D59070BFD345A25" modified="2023-11-08" version="1">MAIPPAQVRIVEVGPRDGLQNIPGKISTSTKIELIRRLRETGLTAIELTSVVSPRAVPQLADCRDLLGHSFVQDLLSSPRQPSPEAGLMRWPVLVPNVKGLEIAVQNGVREVAVFISATEGFSQANIKCSVEEGIARAREVTRVATKAGLAVRGYVSCIFEDPYDGPTPHHAVLHGVKSLLDAGCHEVSLGDTLGVGSPANVHSLLEYLTGHDIPITRLAGHFHDTYGQAVANVWEAYRYGVRVFDSSVAGLGGCPYAPGAKGNVATEDVVYMFQNAGISTGVDLTKLAEAGEWVANELGQTNSSRVGRALLCKTRMSQDKPSPTTTTTTSSLNDALAKFTPCTMSIPAQFSLKWTLMSSSSKPSMENNRFSTDNVSQTLPPKDPDQEKAALSSSQPQSTSSARAWISLRRPSCSSVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XKY8</accession>
    <name>A0A9W9XKY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_000023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793920.1">
        <property type="nucleotide sequence ID" value="XM_056929627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XKY8"/>
    <dbReference type="GeneID" id="81619876"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5494907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="279" mass="32785" checksum="1B34B6FAC46CA8A5" modified="2023-11-08" version="1">MTEMQNLKGSDTGEVIQKLIQGLKEALECKLCRPSPTFASMAGDIKNGHYITSHYPPFFRTNDPNDKGIAIGETTARLFHSWYWEMITHEMREQYYQHVEQALNRLLDETKDIDPEVALLFAHYQTDFHIRQHHFSGRGILNFCRDADDMQQLRHWKWRLHDIDQGKPIDQNNTWPYGCNHTAWPGDENSEMPHAALLWKGNVTMRQKHLNKIRAEWAIITDERRKYREMVLRKQKAKDTITVRLYCRGELKDTRQLKRLTPVEVAYLAEKALQSPVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XL14</accession>
    <name>A0A9W9XL14_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_000092</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793989.1">
        <property type="nucleotide sequence ID" value="XM_056929696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XL14"/>
    <dbReference type="GeneID" id="81619945"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08999">
        <property type="entry name" value="GH43_ABN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF5">
        <property type="entry name" value="ENDO-ARABINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="6">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5494976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="423" mass="46125" checksum="86D2FFB40EECB078" modified="2023-11-08" version="1">MHSSADKEAAKATTSVQSLSASQLSDDERPSDEMDQEKEQLTQEKGPFSRLLARPFNKRRIILLSLIGLILLGLIVLVIVLPLVLMKRHSINHQNSDPGNTYHLFPTTGEANSYHVLDNKPILAVHNFPDPGLLHHNATWYAYGTNPKKHDPQTIHVPVATSTNFVNWTLHDGYDAMPTLGHWELAVNHWAPDVIERDDGKFVMYYSGQLKDGHGHHCIGAAVSTGTDPMGPFVPLNASLACPQKYGGAIDPSPFRDVDGKLYVVYKGDGNSVGSGGYCGNSIVPRRPVPLILQELEGDGITKVGEPDIILDINDTDGPLIEAPNIIRRNDGTYFLFFSSHCFTSLGYNVKYAHARSVKGPYTRAARPLLQTEDFGLDAPGGATLSPDGTKIVFHANCGGQRCMYAGGVHIQPTENTITMAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLX9</accession>
    <name>A0A9W9XLX9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_000524</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794421.1">
        <property type="nucleotide sequence ID" value="XM_056930128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLX9"/>
    <dbReference type="GeneID" id="81620377"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="477"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5495408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="505" mass="55300" checksum="97B99C1CFEC7C4EB" modified="2023-11-08" version="1">MTEGHAAPVPEGPAMAVGDSTGTAPVAAAGSRHPAATQPDQGVTPSLMEQASTGRLTPRPTFLENLASSREAQFHFHRTDSSELERYFQGPRDMDRHSKWPIFMRMHGSVTPKMIVPLLVVGGWATAITCICQFGRNLAINNILLTVLGFVVGLALSFRSSTAYERWADGRKYWAQLIQTSRNLARTIWVNASEREGEDGKVDILRKVSAMNLILAYAVALKHKLRFEPDVAYGDLAGLVGHLDTFALEAHDRNAMQPRPKSLWKSAGEHLGVSFAESNPRKLIKRSKKPLGHLPLEILNHLSAYVDSIVANGTLTSGLHQSQVITMMSTLNEVLTGTERVLDTPLPAAYSIAIAQIAWIYVMVLPFQLYNSLEWVTIPASMVAAYIIIGLATIGSEIENPFGQDVNDLPLDTYCRQIAVELDIITATPPPNVNEFMDRPENLVLFPLSQNSYGEWMTRSKEDIRAALRSKVTAGTAMSTSVDTSSDGSDSATVMSITERTKQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMT8</accession>
    <name>A0A9W9XMT8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_000954</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in splicing regulation. Facilitates post-transcriptional gene silencing (PTGS) by limiting the degradation of transgene aberrant RNAs by the RNA quality control (RQC) machinery, thus favoring their entry into cytoplasmic siRNA bodies where they can trigger PTGS. Does not participate in the production of small RNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794851.1">
        <property type="nucleotide sequence ID" value="XM_056930558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMT8"/>
    <dbReference type="GeneID" id="81620807"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000008">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="72"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5495838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="115" mass="12414" checksum="1CFA315D15A9EDFD" modified="2023-11-08" version="1">MKCANETVTIELKNGTILHGTITSVSPQMNTSLRTVKMTPKGRDPVSLDTINIRGSTIRYYILPDSLPLDTLLVDDAPKPKNKARKEADRGRGGRGGGRGGPRGRGRGRGRGRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XP75</accession>
    <name>A0A9W9XP75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795068.1">
        <property type="nucleotide sequence ID" value="XM_056930775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XP75"/>
    <dbReference type="GeneID" id="81621024"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5496055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="533" mass="59542" checksum="04F2347DE147A9F7" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJC1</accession>
    <name>A0A9X0BJC1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asteroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_009049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786021.1">
        <property type="nucleotide sequence ID" value="XM_056938644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJC1"/>
    <dbReference type="GeneID" id="81628894"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18675">
        <property type="entry name" value="PIN_SpAst1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039436">
        <property type="entry name" value="Asteroid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12813">
        <property type="entry name" value="XPG_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asteroid" evidence="2">
        <location>
            <begin position="163"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5469431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="590" mass="66667" checksum="E0B493F63BBD33D1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJK5</accession>
    <name>A0A9X0BJK5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hexaprenyl pyrophosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_009187</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786159.1">
        <property type="nucleotide sequence ID" value="XM_056938782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJK5"/>
    <dbReference type="GeneID" id="81629032"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5469569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="571" mass="62850" checksum="8EC45CE1FA988090" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJK9</accession>
    <name>A0A9X0BJK9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_009319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786291.1">
        <property type="nucleotide sequence ID" value="XM_056938914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJK9"/>
    <dbReference type="GeneID" id="81629164"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="68"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5469701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="299" mass="33171" checksum="0B39A1CA4AA98986" modified="2023-11-08" version="1">MSSVLTYGYLKVLATLLRAVVSFLEFVTRRPTPRPTDIRYIASRDPGRTIKIHVYRSRQATAGPSPVLINFHGSGFLLPQHGYDEEFCQTICQKTHHTVLDVQYRLAPEHPFPAALNDVEDTIRYVLGRDAEFDRSRISLSGFSAGGNLALAASAVLVPPNTVRAVLAYYPVVDMATDAASKVAPESKTPVIPVPVSRFFNRCYIPAGFDKRDPRISPQYADPDRFPTRMLMITAAADSLACEAEALAQKVEALPGRHVVWERMVGCTHAWDKRTKAGTPEREARDRAYALAVDMLNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJL1</accession>
    <name>A0A9X0BJL1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_009333</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786305.1">
        <property type="nucleotide sequence ID" value="XM_056938928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJL1"/>
    <dbReference type="GeneID" id="81629178"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040937026" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="27"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="171"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5469715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="636" mass="68772" checksum="4AEDFE7096228710" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJL9</accession>
    <name>A0A9X0BJL9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromatin remodeling complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785962.1">
        <property type="nucleotide sequence ID" value="XM_056938585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJL9"/>
    <dbReference type="GeneID" id="81628835"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="643"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5469372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="711" mass="76428" checksum="49A7AD39BC78C8D3" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BLV7</accession>
    <name>A0A9X0BLV7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786707.1">
        <property type="nucleotide sequence ID" value="XM_056938325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BLV7"/>
    <dbReference type="GeneID" id="81628575"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5472161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="22018" checksum="A56F66E38A8473B0" modified="2023-11-08" version="1">MFEGNFLESPQQTAILEEEESIVSVRSLEALFQWLYLRVIKFDIEDAEEHMSAAMELVRLGDKYDIVGLDHEMAQYIKGVLLANLHPTTNRFHRHIDNNTYCITRDHIFSATRLPRDHPVRCILAAASVEGYLRSDTHKFAEETQHHPIFSADLLREVRLALNGIKPVRGATFEDPITGVRSELNSVGLFWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNH1</accession>
    <name>A0A9X0BNH1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Secreted glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_008263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786955.1">
        <property type="nucleotide sequence ID" value="XM_056937863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNH1"/>
    <dbReference type="GeneID" id="81628113"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050226">
        <property type="entry name" value="NagZ_Beta-hexosaminidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480">
        <property type="entry name" value="BETA-HEXOSAMINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480:SF14">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13770)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040894945" evidence="6">
        <location>
            <begin position="23"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="7">
        <location>
            <begin position="49"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5475197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="359" mass="37474" checksum="9182C2B339C0B791" modified="2023-11-08" version="1">MHLSRIPQLLALFLSLASSTQAERGHDLAQEAGHHVIFSYPGISPPAHLFDLIKQGKVGGIILFGENVASNVSTIINQLQDAYKQSQAYVGSPLLIMTDQEGGIVRRLPGGPVSSAKQVGESGDPGAAAIQAGKDAAHTLAEFQVNTNLAPVLGIYREAGDFLDQYGRSYGNNSELVATCGSAFITAQQVAGVIATAKHFPGLGAAGNLNTDEGPVTIDLPLRELRAVDEAPYTNAIAAGVDMVMTSWAVYPALDATYPSGLSNAWVEGELRGRLGFRGVTITDALEAGALESFGDAGNRGLLASQAGMDVILASARDVAQGEAVVNALVSALDNGSLPRGKFTKATDRILALRRKITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNH4</accession>
    <name>A0A9X0BNH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sec20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_007831</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787297.1">
        <property type="nucleotide sequence ID" value="XM_056937432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNH4"/>
    <dbReference type="GeneID" id="81627681"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="11">
        <location>
            <begin position="160"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5475544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="380" mass="42321" checksum="846865ACFFA57A0E" modified="2023-11-08" version="1">MSAAALQVRLKELSAALGQIQPLVDRLRNFTASVGQGDEARLELGAEIHSQLKDAEGDLELLRGDIEALDAGYYGRRKSASAGGDKEAERERVVAMCGRLAEEMKRTRVEFRTAQLQAKRNAELAKRKERELLLMRSHTASEKTTPSQKLTQDDLILNASNDVTAALRRTHTLMQAELSRSQFAQETLEQSTAAISSLSESYSSLDTLLANSRSLANSLLRSQKSDTWYLETAFYILVGTISWLIFRRVLYGPMWWLVWLPVKLSMRFMLVVLGALGISKGTTELVPDSMPTDVTATMHQAATAMTGGPVLVGDELMENDEADEAEQDRIIDQIGRMVENGKWDGADINEDSIEELEADENIIPNPKKRMYEGEIVRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNN5</accession>
    <name>A0A9X0BNN5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_007209</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1). AP-1 interacts with clathrin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787609.1">
        <property type="nucleotide sequence ID" value="XM_056936810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNN5"/>
    <dbReference type="GeneID" id="81627059"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000030">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="12">
        <location>
            <begin position="733"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="633"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="689"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="608"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="642"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="691"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="719"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5477065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="846" mass="92484" checksum="575A0951820DE474" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNT2</accession>
    <name>A0A9X0BNT2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_007212</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787612.1">
        <property type="nucleotide sequence ID" value="XM_056936813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNT2"/>
    <dbReference type="GeneID" id="81627062"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051584">
        <property type="entry name" value="GPCR-associated_LMBR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="590"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5477068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="687" mass="76587" checksum="C9B1A87CC3F03460" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNZ4</accession>
    <name>A0A9X0BNZ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_007241</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787641.1">
        <property type="nucleotide sequence ID" value="XM_056936842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNZ4"/>
    <dbReference type="GeneID" id="81627091"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099128">
        <property type="term" value="C:mitochondrial [2Fe-2S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="57"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5477097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="136" mass="14939" checksum="E2A06954E2D7497C" modified="2023-11-08" version="1">MFRSAIVRSLRASAPRAAMKTAAPIQIRSSPIAVQMAPRMVSQSIRFYSAPAGLSKDEIEGRIVNLLKNFDKVSDPSKITGVSHFSNDLGLDSLDTVEVVMAIEEEFSIEIPDKEADQIHSIEKAVEYIKAQPDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSL0</accession>
    <name>A0A9X0BSL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_006771</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FKBP-type PPIase family. FKBP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788307.1">
        <property type="nucleotide sequence ID" value="XM_056936372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSL0"/>
    <dbReference type="GeneID" id="81626621"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000025">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF443">
        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5480877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="121" mass="12965" checksum="2764BF7CADA1ADC4" modified="2023-11-08" version="1">MGVEKTVLKPGNGVDFPQKGDNVAMHYTGCLYDASAAANHYMGQKFDSSRDRGTPLASPIAVGRLIKGWDEGVPQMSLGERAILDISPDFGYGPNGFPGLIPPNSRLVFDVELVKINNKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BT98</accession>
    <name>A0A9X0BT98_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein/NADH dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_006365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788891.1">
        <property type="nucleotide sequence ID" value="XM_056935967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BT98"/>
    <dbReference type="GeneID" id="81626216"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040049">
        <property type="entry name" value="Ribosomal_mS25/mL61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="6">
        <location>
            <begin position="49"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5482919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="206" mass="23398" checksum="6BBCC8F7E7A29395" modified="2023-11-08" version="1">MVNLFKRMRKLKTILDIRTGLGAAIFPNPTSATKEFPPVTRLHLTYARKIYNGHQGARHFWRNCLPRLKYHNPAVRMTVQQTEDQSLTPSLTIYFAERLSSTAPAIIGSKKISDKHAPAPESSEKIAVVDLKDLTYKEIWSRVQAATGAEEVRTSAEDEAERKRLDAITAKAGKDRERIQAIRQAKKDQERMLAEARGEVEKMKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BU32</accession>
    <name>A0A9X0BU32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphotransferase</fullName>
            <ecNumber evidence="8">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_004742</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789538.1">
        <property type="nucleotide sequence ID" value="XM_056934344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BU32"/>
    <dbReference type="GeneID" id="81624593"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000034">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000006">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF30">
        <property type="entry name" value="GLUCOKINASE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="9">
        <location>
            <begin position="9"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="10">
        <location>
            <begin position="226"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5484754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="497" mass="54728" checksum="95333188A7A000EC" modified="2023-11-08" version="1">MSSALLNEAERIAREFDYPAEEVKRGVEEYIRESNEGLAKENATLSQIPTFVTAVPNGTEKGLYLAVDLGGTNFRVCSVQLHGDTTFSLTQSKIMIPRELMASGTSKELFLFLARQIEAFLRIHHNEHFEAHQRRRRDGNKIEDLFDLGFTFSFPVRQFGINSGTLIRWTKGFNIPDAVGQDVCALLQSAIDELNLPVRVAALVNDTVGTLMARSYTSPGETGTLLGAIFGTGTNGAYVEKLDKVTKLKDMKDAQYDTSTGEMIINAEWGSFDNHMSVLPDTVYDRELDADSNNPGVQMFEKRVSGMFLGEILRRALLSLHNNPKFGLFKSSQNSSVSIPSDSLFYRQWGLDTSLLSQVEADTSKDFTEVKAALKDHLNIEKPSNAECQAVKTIVHAIGKRAARLSAVAIAAVLIHTGKLETENMVDVGVDGSLVEFYPKFEDYIREAMREIPQVGVAGEKKVRIGISKDGSGVGAALIALVASKDDTMKMPTQKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BU33</accession>
    <name>A0A9X0BU33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="2 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_006080</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="2 12"/>
    <dbReference type="EMBL" id="JAPWDQ010000007">
        <property type="protein sequence ID" value="KAJ5483880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789150.1">
        <property type="nucleotide sequence ID" value="XM_056935682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BU33"/>
    <dbReference type="GeneID" id="81625931"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000001">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="14">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="822"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5483880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="868" mass="96458" checksum="F1F13253C48ED8EE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUG2</accession>
    <name>A0A9X0BUG2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_004789</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789585.1">
        <property type="nucleotide sequence ID" value="XM_056934391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUG2"/>
    <dbReference type="GeneID" id="81624640"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="6">
        <location>
            <begin position="92"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="275"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="380"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="701"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="869"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5484801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1183" mass="133248" checksum="31BBCC3912FD6046" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUS6</accession>
    <name>A0A9X0BUS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_005477</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790273.1">
        <property type="nucleotide sequence ID" value="XM_056935079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUS6"/>
    <dbReference type="GeneID" id="81625328"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000066">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000026">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="8">
        <location>
            <begin position="65"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5485489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="213" mass="23606" checksum="6BAC2CE9C3B42965" modified="2023-11-08" version="1">MAATGLPSGWEVRHSNSKNLPYYFNPSTKESRWEPPADTDTETLKEYMATHHSMAHSNDVAGQGEGKIRCAHLLVKHRDSRRPSSWREADITRSKEEAIEILKGYEQRIQSGESLGDIAVSESDCSSARKKGDLGFFGHGEMQKEFEDAAFALKPGQVSGIVETASGVHLIQRVLDDPAVERDIEVSVSRIWLTYGSSKDSEASLQNEPESLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BV43</accession>
    <name>A0A9X0BV43_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_005238</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790034.1">
        <property type="nucleotide sequence ID" value="XM_056934840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BV43"/>
    <dbReference type="GeneID" id="81625089"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720:SF2">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="28"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5485250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="502" mass="54382" checksum="6DA7FBCE17A2580A" modified="2023-11-08" version="1">MASLSVQLTAPNGRVWSQPTGLFINNEWVKSSDGEKIATINPATAKTITSVYAASTQDVDKAVKAARAALNHSSWRDLPGTERGKLMNRLAQLIEDHRETLATIETCDNGKPYTVSRDDDLTETAETIRYYSGYADKTFGQVMGTTQDKFAYTVREPIGVCGQIIPWNFPLSMAAWKLGPALACGNTVVLKPAEQTPLSILYLANLIVEAGFPPGVVNIVNGHGAIAGAALASHLDVDKIAFTGSTATAKHIMKMASVNLKNITLETGGKSPLIVFDDADLEQAVEWAHIGIMYNQGQICTATSRVLVQDTIYDKFLAAFKAQVKNVSKVGDPFDESTFQGPQVTQAQFDRIMSYVDIGKSEKATLTLGGKPYKGVGDGKGFFVEPTIFTDVSPSMRIYQEEVFGPFVVIARFSTEEQAIDMANDTTYGLGSALFTTNLTRAHRVAKKIQAGMVWINSSNDSDWRIPFGGVKQSGIGRELGQAGLDAYSNIKAIHVNMKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BX97</accession>
    <name>A0A9X0BX97_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_003435</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790578.1">
        <property type="nucleotide sequence ID" value="XM_056933037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BX97"/>
    <dbReference type="GeneID" id="81623286"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF103">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="55"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5488545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="505" mass="56218" checksum="CE41F2B0CF1B0E83" modified="2023-11-08" version="1">MEKQDTPRLRGATELNETKIDSTLVARDVDIGQILDANVTPEMERKVLAKLDLYLIPLMGFCYMLQYMDKLALSQATLFNLTEDLNLRGKEYNWASAIFYFGYFAWSWPSSYLIVRLPLGKYLGVAVFVWGGILMCHAACTSFSTLMVARFFLGVGEASIAPGFALITGMFYRREEQPARQAAWFVGNSIATVIGGVVAYGIGMIHNSTVYSWQLLFLVLGAITSGYGIILVFLLPDSPAKAVFLTKPERSIAIQRTLQNKTGVLDTGKFHWNQVRLAILDPQTWFLVLYTFCVNLCNGGITSFASIIIAGFGFSNLKALLIQMPLGAAQLVFLILTSGIATFFRNTRILMMIVNTLASMIGMVLIWKLESNDRAGRMTGLCLSAIFAANIPLSLSLISSNVAGFTKKSTVSALMFVAYCVGNIVGPQFFVPTEKPSYPTGIKASMAGLILGVFFLMCLYVFYVWENRRRDRVYGTPEQFTETEELQDELSNRTDQEIESFRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXM2</accession>
    <name>A0A9X0BXM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790672.1">
        <property type="nucleotide sequence ID" value="XM_056933131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXM2"/>
    <dbReference type="GeneID" id="81623380"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5488639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="74" mass="7899" checksum="EEDD1BB9B57DB6E5" modified="2023-11-08" version="1">MIRGLLGAMVLSTPSKGSLTPAVADAATKSLDDGVMLLGCLKSRDKRFPTGLTESASQAYDCGWMMEGFRMQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXP0</accession>
    <name>A0A9X0BXP0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Cellulase</fullName>
            <ecNumber evidence="3 10">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_003423</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 45 (cellulase K) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3 10"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790566.1">
        <property type="nucleotide sequence ID" value="XM_056933025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXP0"/>
    <dbReference type="GeneID" id="81623274"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22278">
        <property type="entry name" value="DPBB_GH45_endoglucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000334">
        <property type="entry name" value="Glyco_hydro_45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22514">
        <property type="entry name" value="EXPB1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01140">
        <property type="entry name" value="GLYCOSYL_HYDROL_F45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040993899" description="Cellulase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like EG45" evidence="13">
        <location>
            <begin position="31"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="14">
        <location>
            <begin position="225"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="178"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5488533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="262" mass="26537" checksum="D938CF00ACFE5AED" modified="2023-11-08" version="1">MKGGVAVLLLELFTSAAAYKATTTRYYDGQKGACGCGSGSGLFSWQLGIGNGVYTAAGSQALYDTAGANWCGAGCGKCYKLTSTGAPPCTDCGTGGVAGKSIIVMVTNLCPYNGNQQWCPNPGATNQYGYSYHFDIMAQNEIFGDNVVVDFEPIACPGQATTDWQSCGCYGQTETDTTPVGLESGGGGSGGSSQSSTTTLQQSTTTRTTLTPTTTSGSGSGSSGGAQSVYGQCGGSGWTGPTNCASGSTCKAQNQWYSQCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXR6</accession>
    <name>A0A9X0BXR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791073.1">
        <property type="nucleotide sequence ID" value="XM_056933532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXR6"/>
    <dbReference type="GeneID" id="81623781"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="208" mass="22704" checksum="BD5CCAD08F7D74C6" modified="2023-11-08" version="1">MSRRISVVDLTLSQTTPLALRSSLEVSPTLSPSSIRSDRSEPYSMPRGTKRKRRQPDDPDDQSRPGTPDVAGVQIESIDLTDVTDTSSFARALAKKRPDEIQAQSPEQPDKPQATLAAYQCPVCMDHLEDSTTTSCGKRQSPYSVSGEEITSDKRLHIPQGISSATNVSSSTCALLKAGVLNKISQRREHAQCAGSLFHRRIQGLDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY49</accession>
    <name>A0A9X0BY49_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3 15">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_004039</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP</text>
            <dbReference type="Rhea" id="RHEA:16341"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:16342"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3 15"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791182.1">
        <property type="nucleotide sequence ID" value="XM_056933641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BY49"/>
    <dbReference type="GeneID" id="81623890"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000018">
        <property type="entry name" value="Phosphomevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016005">
        <property type="entry name" value="Erg8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017288">
        <property type="entry name" value="PMK_GHMP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="17">
        <location>
            <begin position="190"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="47"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR017288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5489149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="489" mass="53280" checksum="A20D0E731AB52EC0" modified="2023-11-08" version="1">MSPQPSSITALSAPGKVLLTGGYLVLDRAYTGTVFALDARIHVVVQQKRRGHRRGPSTASADVRSTAPSGDAHDNKAEDEVVEEQDTIVVVSPQFKDAIWEYGVQRCENGGGVKAVQKSKGPRNPFVETSLSYALTYISYVADSKDFGSLTVTILADNDYYSETATSKDWSIKAPSERFVHFGVPLLEAHKTGLGSSAALVTALVSALVIHRTMQASDLAVGRDKLHNLAQAAHCAAQGKVGSGFDVAAAVYGSCLYKRFSPAILESIGDVGSSGFDERLFAIVEDVDPKHPWDTECVDFGMQLPRGMQMVLCDVECGSQTPSMVKKVLEWRKNNRQEADILWGTLQNNNERLRQELKRLAQHPDANADNEFTEVGALLQRTRHLIRAMTRQTEVPIEPRVQTELLDSLTEIDGVIGGVVPGAGGYDAIVLLIRDDPSVVTRLNERLVTYESAVEDDFGGKIGKVRLLGVRHGSDGVMNEELKQYAGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZL7</accession>
    <name>A0A9X0BZL7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792782.1">
        <property type="nucleotide sequence ID" value="XM_056932823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZL7"/>
    <dbReference type="GeneID" id="81623072"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="376" mass="38811" checksum="4B57128BA48DA1C0" modified="2023-11-08" version="1">MQSTTPRSGSTTPLGRDPDIQWLQLLAHTKCKTPAILSSGPAIPSPSSPTPLQSAATGTGTNLKNNHSGRAHSCSSATSYFTLLSVTGDAQHLQHGDGRQRSARGQQYAGSVTPPGRHMDDSSWIAWFSARGAGSSRAPMHQPEPQHGHGQTGDSTSRIHDAGPSGNSDQSYFPSKPPVQLPVQSQPQSQSQGPSQDQTTLPDQTIVPGGHSLGTSAFTSTSTSTSTSTITSTTRDTTPPFSISSTASGPGTSFSSPLAPLTDAEIDAMIQQFPTDSTDGFSWAFSDPSTYDAGLFDLAETDPGLASWLNEQHAFALHLGDGTAGAGAGAAGFSGPTSPGKRSLTLDGYPGEMSAEQGMGWDVGIGMGIGSKKLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZS4</accession>
    <name>A0A9X0BZS4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable E3 ubiquitin ligase complex SCF subunit sconB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Sulfur controller B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sulfur metabolite repression control protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_001593</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF(sconB) E3 ubiquitin ligase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793227.1">
        <property type="nucleotide sequence ID" value="XM_056931196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZS4"/>
    <dbReference type="GeneID" id="81621445"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF745">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="262"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="364"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="452"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="493"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="533"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="573"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="615"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5492847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="701" mass="77896" checksum="322673ACB55ED316" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZY9</accession>
    <name>A0A9X0BZY9_9EURO</name>
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        <recommendedName>
            <fullName evidence="8">PARP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">N7539_001669</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiales</taxon>
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    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793303.1">
        <property type="nucleotide sequence ID" value="XM_056931272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZY9"/>
    <dbReference type="GeneID" id="81621521"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
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        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
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    </dbReference>
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        <property type="entry name" value="ZF_PARP_2"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
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            <end position="382"/>
        </location>
    </feature>
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    </feature>
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            <end position="174"/>
        </location>
    </feature>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="6">
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5492923.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="382" mass="42196" checksum="F8E89A67D16C1B11" modified="2023-11-08" version="1">MLSVHRAQIANPYCLDLLLVLTILNLLAEASPNNRAGCQNKECKDQKIKITKGEIRVGTWVENERFQSWQWRHWGCTTPLILSNIMKNVFEKEELEGDEDFDLIDGWEDLPEVHQEAVRKALAEGHVPDEDWKGDVECNRPGMRGFRLSKKKAAAKKDAEEEDDSKSENAVDDETSTKKAQPAKATKSTPRAKAKKATDEEDEVKEPQETKRATRGKKPVKKPVVEESADEEAPATPAETKEKAKRAARGKAAAKAAIEQSEAEAEAEAEEVKPAKGRGRPAKSATTTKEASKPAATNGRKRKATDEDPESGKKAEKPKRGRKAVAAAKEEIEEREPASDEAPDGQTEPDQTSSAQEMPEESTSEDVVPQKTRRRSGRVTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0E8</accession>
    <name>A0A9X0C0E8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_002253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793887.1">
        <property type="nucleotide sequence ID" value="XM_056931856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0E8"/>
    <dbReference type="GeneID" id="81622105"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5493507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="79" mass="9074" checksum="A8276D3D637EABAE" modified="2023-11-08" version="1">MHTRAAMFISIEISEGNRKTLEHAPHLVQLFCPLGSGIKSRISEDNRVLLLQMIDKIPEDSKKEQHFMVAERVPSIEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0K0</accession>
    <name>A0A9X0C0K0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_002137</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793771.1">
        <property type="nucleotide sequence ID" value="XM_056931740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0K0"/>
    <dbReference type="GeneID" id="81621989"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002614">
        <property type="entry name" value="Origin recognition complex subunit Orc5, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047088">
        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048866">
        <property type="entry name" value="ORC5_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14630">
        <property type="entry name" value="ORC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21639">
        <property type="entry name" value="ORC5_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="8">
        <location>
            <begin position="13"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="ORC5 lid" evidence="10">
        <location>
            <begin position="216"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 5 C-terminal" evidence="9">
        <location>
            <begin position="325"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5493391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="58005" checksum="3C56294604871D76" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C1V5</accession>
    <name>A0A9X0C1V5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_000063</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793960.1">
        <property type="nucleotide sequence ID" value="XM_056929667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C1V5"/>
    <dbReference type="GeneID" id="81619916"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5494947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25617" checksum="F8A3E95637564740" modified="2023-11-08" version="1">MASLSTMRPLGCLRSLWKAPDMIQSQITRRCLSTVYSQRPKRVPLPQGVPEQFLSQLPTRMRPENTPKPIKVFNPPPSARKACKDPVAKVTESQLETLDPKGERKALFDYRRNPRSVRPGDIVRVTFKNGDPFNGVVLSIKLRGIDTSFLLRNELTRVAVEMSVKVFNPNIQSVEIVQRAQRKIRRARLYYMRSRKHDRRSVENIANAYVRQKKAFMGAGSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C214</accession>
    <name>A0A9X0C214_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794024.1">
        <property type="nucleotide sequence ID" value="XM_056929731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C214"/>
    <dbReference type="GeneID" id="81619980"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30177" checksum="B9B9D0023C1A1590" modified="2023-11-08" version="1">MSFLVVPLLKFGVSKAKKHHAAKKQAKQADQFQQPGNAYNHGPEAPIHMANYPANIGPGADLHFPPAEAQMSKRAKIMAIFTAGLRFLQIVFGLTVVGLYGRDVHHDHENGESARARWVFALTVAVLATLTAGVSFGVPLIMRSLKGGAGAGVGRSQLRLPQFVWEFILCILWLTMFGIFGKMYIGVYPVTTHGADSSGKRDTAHGSANNTTTTTTPAISPLGDAAKINRMRHAVWVDLINLLMWVATASFVLLRWLKSRRAARGDEMDVEKDNQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C257</accession>
    <name>A0A9X0C257_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_000262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794159.1">
        <property type="nucleotide sequence ID" value="XM_056929866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C257"/>
    <dbReference type="GeneID" id="81620115"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5495146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="484" mass="53947" checksum="7E9AE1E165A3A768" modified="2023-11-08" version="1">MDTSCPVRTFQLRLIEKMTSDEWECPEIARLQAICTPKITPENEQFVRTYHPGLRCHDYVFVSHPQYGPEVWLVYDRIDYITVAGRPCHTFPKDSGNLCPEGSVQSRPALSDNRLFHNYHINPRKILSPEQLDCLRDLFPTAIGAQVLVSGFLVVLMKSQSDIRAAYHQGSVSEVAGLAVTFNDFSLQPKSRTWISGVELRGGSRPLNGQGCLGLRLQLVDGESAVTTITHGFMADLPPAKPDRIETPELEDLGELSRQNAPIDKEIWLKEEEKRVGTISLTFDNPSRVYPFPTGYMHDLSLITGKSLPSLLPPPGHALVSDWASYSEALSGEAVHTVRMATWTGQAVNPQGSIIEDSVLDSSVIGVQYLWDRSTHSQKASLLWITNPLIARLGEWCGSVLCLGTRHDMLSKAIVFQNYQIQYAPNTDLPVENLYRPVIGGGFLLPDYIRAAKIVAGKQAIEDDDLRQRSMRERLARALGIGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2M1</accession>
    <name>A0A9X0C2M1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Class I glutamine amidotransferase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_000320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794217.1">
        <property type="nucleotide sequence ID" value="XM_056929924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2M1"/>
    <dbReference type="GeneID" id="81620173"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF6">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5495204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="34647" checksum="6104991AA0CF751B" modified="2023-11-08" version="1">MVHNIHVAVLDVDIPARGLYEARGLCSAHFRDILKETAAHLNKNDPSIPDPIEITITPYDIRGGHYPDFHLLRGDPSQEQFPVYRPIDAVLVTGGSPGVYEMPNSPWMQMLERFIKAVYRDYPEVRLMGTCFGHQLISHALVRDPADPDRDVYVEKCPLGREVGIYTVQMEEQFLQHFSSALGHLPQGQLRIQMFHGDRVMAVEKGQTVSLCDTPPVSLPAPWINIGSTPICPIQGLYNPGRVLTVQGHYEMDAFATSKMCIENAPIMGWKESKLALYLEQVGPDTKERRDDARAFATAVILFLADLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2X0</accession>
    <name>A0A9X0C2X0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794924.1">
        <property type="nucleotide sequence ID" value="XM_056930631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2X0"/>
    <dbReference type="GeneID" id="81620880"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="251" mass="28409" checksum="C7C6BD39449B34BB" modified="2023-11-08" version="1">MADVRSLLRNELASRKGASQPNTTGNRVSKKRKVDHSDGVMHKKLRSTDLESVQAAVNVQARASNPDVTVGEDIIERVDEDEPIGPEPPSQPEEDVSMTMRTEFPADSAREVSSQAVDEDEWAAFEREVVAPTKTSNVPAVVSAQATIVAAPVTTEELAMQQQSERISSTRSREAELAGEREDAARFLEEEFDEMDQLEERVRRLKQRREELRQKRISEETTDTTVADDQRVEDSGSEEYEDEDWDDWRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C3C6</accession>
    <name>A0A9X0C3C6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domaingeneral substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_001161</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795058.1">
        <property type="nucleotide sequence ID" value="XM_056930765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C3C6"/>
    <dbReference type="GeneID" id="81621014"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000061">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="68"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5496045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="542" mass="59882" checksum="99DD69224E9CF8CA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKU6</accession>
    <name>A0A9W9WKU6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_009522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785612.1">
        <property type="nucleotide sequence ID" value="XM_056939117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKU6"/>
    <dbReference type="GeneID" id="81629367"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.70">
        <property type="entry name" value="Get5 dimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049256">
        <property type="entry name" value="Get5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024737">
        <property type="entry name" value="Get5_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17183">
        <property type="entry name" value="Get5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12754">
        <property type="entry name" value="Get5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Get5 N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Get5 C-terminal" evidence="3">
        <location>
            <begin position="178"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5466566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="24746" checksum="F9152E43E8BF37A2" modified="2023-11-08" version="1">MSELAFAKSFLASLDSRPIKLRADHVFDPEQVGLRVPYTLPRFQPPHPEMPKKTQQAQAPGSSKSASIKVKSARNPTLDFSIPNAPISTTTIQDLKDAVRQRVSDAHGNPVALDKIKILYRRKPVPGSGKTVAEVLADEPDTLAGGKEVEFGTMIIGGAKTLDAVEPSSEVVAEQDIPKPAVGPSGVEILKTDEFWDDLRGFLEQRLKDSDEAKHLAVLFKGAWRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL09</accession>
    <name>A0A9W9WL09_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleoporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_009073</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056938668.1"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="P:protein import into nucleus"/>
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    </dbReference>
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            <begin position="769"/>
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            <end position="1160"/>
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        </source>
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    </evidence>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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    </comment>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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            <dbReference type="ARBA" id="ARBA00012646"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL38</accession>
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        <recommendedName>
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        </recommendedName>
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            <authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF95">
        <property type="entry name" value="NUCLEOLAR PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="193"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="192"/>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="327"/>
            <end position="375"/>
        </location>
    </feature>
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        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
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            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
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            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5469489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="392" mass="43633" checksum="C36146EF26314C01" modified="2023-11-08" version="1">MAEISESSLKKRKLQDGPELEIDLGAPEPPSKKALRKAKKGKSVDSKTQEIETSSANVTAPATAESSEPKDTDDSQGKRSQYGIWIGNLSFNTTKDDLRQFIIDNCSVTNEMITRIHLPKGPEKFGRPQNRGFAYIDFSKKKALEEAIGLSEQLLAGRRVLIKNANSFEGRPEKSAEQTSAAATAKPGHPPSRRIFVGNLSFDVTKESLEAHFARCGTVTNVHMATFQDTGKCKGYAWVEFEDIAAAESAVKGFVMEKEDDEEQEAEEEQQQSDGNSDSEGETKKAKSKPKKKTKKPFQRRIWVNQLLGRRLKLEFAEDATTRYKKRFGKDGEGRKNDQPAITEAGTEPSAEQARPRKQRRPSVDESRYSKETVQRLSGAIVEAQGKKVTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLH1</accession>
    <name>A0A9W9WLH1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_009332</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786304.1">
        <property type="nucleotide sequence ID" value="XM_056938927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLH1"/>
    <dbReference type="GeneID" id="81629177"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="49"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="342"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5469714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="378" mass="41335" checksum="7083EEB6A37FBED5" modified="2023-11-08" version="1">MAANTRLQNIALGILILFTALGGIAVILRLWSRKIKRSAPSADIKANFVGWHYKDIPPTEYDPKTAMIWNYVVQLVYNPALTFIKLSILLFLRRLDSHSRVVSILFWFATTVVVGLFVAVLFVDIFQCQPVAYVYDSSIEGKCIAQGVFYVSTAALNLFTDVIVMAIPIIITWKLQMPVRQKLAVCLILCLGGIATAIGVWRLVILTQGFILHMPNPDPTYNISFVSSAIECNTAVLTACAPSMKAIARRYVPRLLGTSRRDTSGYGAGTSGSRSRFPGSNLFSGNKSQLRSHADDEYEMADPNNGVSVSGGKRNSSAFDMRKYRRNGDSVSLSSGSLEGATGIVKTMDVSVQYTGGEGPRDDGRSRDNKHSSVDSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WM10</accession>
    <name>A0A9W9WM10_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_009285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786257.1">
        <property type="nucleotide sequence ID" value="XM_056938880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WM10"/>
    <dbReference type="GeneID" id="81629130"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5469667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="133" mass="14594" checksum="39E1DF23321B9E08" modified="2023-11-08" version="1">MASLPSTIIVDQRSKLVTCNPMRWVCSCSTVVRIHLRSAFTNEVDVEWMEFTQQLTILGLLLSLSNDDAVREVTSEDTPHGLNSINWVQTFFTLCKDSYLAPHLATSAISLVDGKTGLGQAAGAVLGQYQSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQH0</accession>
    <name>A0A9W9WQH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786366.1">
        <property type="nucleotide sequence ID" value="XM_056938358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQH0"/>
    <dbReference type="GeneID" id="81628608"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5471820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="625" mass="71315" checksum="9A76C695DDAB6E3E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQS5</accession>
    <name>A0A9W9WQS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Allergen Asp f 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5471972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786518.1">
        <property type="nucleotide sequence ID" value="XM_056938136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQS5"/>
    <dbReference type="GeneID" id="81628386"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038903">
        <property type="entry name" value="Allergen_Asp_f_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25312">
        <property type="entry name" value="Allergen_Asp_f_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040756954" evidence="1">
        <location>
            <begin position="23"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="254" mass="26726" checksum="0A6E69F64729988B" modified="2023-11-08" version="1">MTLLCSWVLILPLVFSYGVTYAEFHASTSPARSSGKVSVILSRLSSTSQFGGTTNSSGYGVKYIGNVGDPYGSNIIEVPENTANQYKYVLRFEGPVAGESWTVVIWNKIGPDGLLSGWYGQACRKFILKSGQFRYIAVDENSQGGWAAAPGDSIPVDSQGGYASTWGEFDFGSVINSGWSGFDVSAIAAQNAGLPVQGMKICDVLAGICSFVTKDAALIHNAYISSLAEVGGIGGNLYPGPVRLAVTIGYDTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WRA7</accession>
    <name>A0A9W9WRA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786373.1">
        <property type="nucleotide sequence ID" value="XM_056938365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WRA7"/>
    <dbReference type="GeneID" id="81628615"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5471827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="451" mass="49374" checksum="7E1285D2695E74F7" modified="2023-11-08" version="1">MLKLEESDGQSDEVLLAPVLTGPVLNQPSLGPTQYGLLGGVKRIDTPIYSTKDDELTKNDPRLFFNVSSPSSVFICGSQGSGKSHTLSCLLEGCLIPSKAGRLLSPLTAVVFHYDAFICDGGGSPCEAAFLSSHPNLKVRVLCAPTNLRTIKGTYSRFNIEVQPLQIDQSHLNTKRMLDLMSVARDSGAGPLYLQTVQRILREMRLLQQSTGCLFNYQDFKSRVLGSGLLTSQMEPLKQRLDILESFMPPNQARTDYKVKGTKAKPHDGGSIWVPKASQLTIVDLSCPCVSPDTACSLFNVCFGIFMEQDTRIGRIVALDEAHKYMKDSVEAQNFTDTLLSTVRLQRHLGARIFVSTQEPTISSDLLDLCSVAIVHRFSSPAWVRALQSHVAAAALNLHAAKDSQAKDEQALLDIPTRLSIFHRIVNLKVGEALLFSPGAMLSIVSKEAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WT97</accession>
    <name>A0A9W9WT97_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xylosidase/arabinosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_008165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786857.1">
        <property type="nucleotide sequence ID" value="XM_056937765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WT97"/>
    <dbReference type="GeneID" id="81628015"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18619">
        <property type="entry name" value="GH43_CoXyl43_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052176">
        <property type="entry name" value="Glycosyl_Hydrlase_43_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772:SF5">
        <property type="entry name" value="BETA-1,4-XYLOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5475099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="343" mass="38370" checksum="4859CEF9237CDC8D" modified="2023-11-08" version="1">MSSSSNPKPLITHLYTADPSAHVFNDKIYIYPSHDRETDIAFNDNGDQYDMTDYHVFSMDSIDGPVADSGVVLSADKVPWVSKQMWAPDAATKNGKYYLFFPARDHEGIFRIGVAVSDSPTGPFAPEKSYIPGSYSIDPAVFVDEDDQAYLYFGGIWGGQLQCWEKAESSEAKGAELDPQMNGLVFNKNKSGPQEPSGPGVPALSPRVGRLSDDMLSFAAPPQEMQILAPETGAPLAADDHERRFFEAAWMHKYKGKYYFSYSTGDSHYLVYATGDSPMGPFTYQGRILEPVLGWTTHHSIVEFKGKWYLFYHDCELSKGVDHLRSVKVREIVYDEEDKIHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTI6</accession>
    <name>A0A9W9WTI6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_008162</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786854.1">
        <property type="nucleotide sequence ID" value="XM_056937762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTI6"/>
    <dbReference type="GeneID" id="81628012"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032108">
        <property type="entry name" value="CLIP1_ZNF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF83">
        <property type="entry name" value="TIP ELONGATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16641">
        <property type="entry name" value="CLIP1_ZNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="8">
        <location>
            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="405"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="468"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="609"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5475096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="680" mass="74675" checksum="64F9F99CBDB32B6E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU91</accession>
    <name>A0A9W9WU91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_007909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787375.1">
        <property type="nucleotide sequence ID" value="XM_056937510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WU91"/>
    <dbReference type="GeneID" id="81627759"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5475622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="134" mass="14536" checksum="1821BA4A818FF7CF" modified="2023-11-08" version="1">MRSNGGIHHHAANLKPVPLLATSKEGTATIAMEALLTRGREIPLDSSDSHCPQEWGVFIYQVVGYTSDDIVVRRAALALGSSEFGEWETFPATEATGGDRERASVWGQAERIVDVVDVVVARDGMPTSSYYQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUC3</accession>
    <name>A0A9W9WUC3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_007954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787420.1">
        <property type="nucleotide sequence ID" value="XM_056937555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUC3"/>
    <dbReference type="GeneID" id="81627804"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5475667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="90" mass="10417" checksum="8FC9A76055CB85D0" modified="2023-11-08" version="1">MTANSAAETLRERWKNLPVEPGYFDDCILHPINYIAQENYERKLYCFECEEIVFNDGKGEEIWKTSGSGFMDALPKQVSVMIKKGKHRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUY2</accession>
    <name>A0A9W9WUY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S36, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_007339</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787739.1">
        <property type="nucleotide sequence ID" value="XM_056936940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUY2"/>
    <dbReference type="GeneID" id="81627189"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020373">
        <property type="entry name" value="Kgd4/YMR-31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE DEHYDROGENASE COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10937">
        <property type="entry name" value="Kgd4-YMR31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5477195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="12584" checksum="E2C3DE945ADDEC91" modified="2023-11-08" version="1">MRASIALFNAGRTPLIRFVGKRSVPKSIDHTPRVHPASPTGSLPDSFATYRAKAQQHGPLGRAQFSGRVGAQPGSALGPVAPKAGEFFDRAELPARFGRLPWTAAEIEAIETGGASMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV14</accession>
    <name>A0A9W9WV14_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">18S rRNA (Guanine(1575)-N(7))-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_007402</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787802.1">
        <property type="nucleotide sequence ID" value="XM_056937003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV14"/>
    <dbReference type="GeneID" id="81627252"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="9">
        <location>
            <begin position="52"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="10">
        <location>
            <begin position="212"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5477258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="280" mass="30582" checksum="2254059D6271B50D" modified="2023-11-08" version="1">MSRPEDILPPDLFYNDNESRKYTTSSRIRNIQADMTQRALELLDLKSPSLILDLGCGSGLSGEMLSEVSPEDGGPHTWVGMDIAPSMLDVALQREVEGDLFLADIGQGVPFRPGTFDAAISISAIQWLCNAETSDVSPEGRLKRFFEGLYASLRRGGRAVCQFYPKNDIQRSMISGAAIKAGFGAGMLEDDPGTKNSKLYLVLTVGGGGLSGDITGVVNGMDGVNVLDARRKAQEMNKARGTPRKGDKEWIMKKKEQMQKKGKVVKANSKYTGRKRRIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVA4</accession>
    <name>A0A9W9WVA4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
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            </authorList>
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            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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        </location>
    </feature>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5476941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="483" mass="54756" checksum="B594044321C53F9E" modified="2023-11-08" version="1">MLPDFLQSSYARYKADTSTFATWLLETAHQCGYQPPFLADALPQASKGKGRSRKKGNQRAKQGGKKTNKVKPSIGDSDANPIQYSATTKDLQKLAEVIAGSSLAVPRSILTIAKRAIKLRKTVTSWFLGRGNSAYTNQHAHFITVLEQICEVLEWKTSKTSKQDAKQPPPPKSEEELDDANSDSFLNRFAVLTVEEPQETTETQATPVETKKIVKVNDVEEDEDEEADSLLGQLLFKSLCLLQDLSNIRKFISITWAEYRDQKIDLMNAAIVTDSALKLARDLSREVEADWRATLPKRREGFQDIIYKIAVFNRGISGGPSAEIGLPYNKHIANEAEWCYIPTKILLDSFTDVLEDGYLPVFKKGHFGHYDPQADRERMSLRQKFNEDKILLCSILPDFCMMEPLKIHLPTEDAITQGLTEYARTKRVTLWLSFTSQSFLDIHHIIRHTPSGAFRDLQISRIRINETIEDYFQLAKTHPSPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1Q7</accession>
    <name>A0A9W9X1Q7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vacuolar cation-chloride cotransporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_006728</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788264.1">
        <property type="nucleotide sequence ID" value="XM_056936329.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81626578"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cell volume homeostasis"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Solute carrier family 12 member"/>
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        <property type="entry name" value="SLC12_C"/>
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        <property type="entry name" value="GH08340P"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SLC12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="551"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="130"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="10">
        <location>
            <begin position="619"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="10">
        <location>
            <begin position="1213"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="715"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="927"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1010"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="735"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="927"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1028"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1055"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1073"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1124"/>
            <end position="1136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5480834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1280" mass="140395" checksum="7A3D58FD1DB2D794" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2F7</accession>
    <name>A0A9W9X2F7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-ketoglutarate-dependent xanthine dioxygenase xanA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_007064</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788600.1">
        <property type="nucleotide sequence ID" value="XM_056936665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2F7"/>
    <dbReference type="GeneID" id="81626914"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT XANTHINE DIOXYGENASE XAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="32"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5481170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="355" mass="40190" checksum="30C7B0CA2DC13726" modified="2023-11-08" version="1">MAVLPPTIRLFQPAPGSQIDFGACIEGINLEDLTVVVFKNQHRLSARAQYELTKRFDPAAENYGHGKTIDAKRSILHPDLKTVPHQPQVQIIGNGSIKSYEGLENFQLRHPHHRTFHKDHIPDEKDYDYTRFYRWHIDAALYDLNPPQVTTLLAVQVPKGRRQTLLYDDGSNETMDVPLGTTAFVSGERMFELLSPAEQEFVRTSKVEYAPHPYIWMSPAHSRSTGLGLHSEGLELPDSDLPPIDPTKIKILPMLWKNPVTGKLALQIHPSAIRRIHLADGSAIDDLTRVREIVYRLQRPGIRPQFVYAHDWEEGDLVLFNNRGLLHSVVGAFMPDEVRLFRQCNLAASEAPVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3A3</accession>
    <name>A0A9W9X3A3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Charged multivesicular body protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_006206</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788732.1">
        <property type="nucleotide sequence ID" value="XM_056935808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X3A3"/>
    <dbReference type="GeneID" id="81626057"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5482760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="216" mass="23987" checksum="C21A73E29E7B1D64" modified="2023-11-08" version="1">MNRLFGTKSTAPKPTLDGAISKVDDRVASIDVKLSALNSELSAYQAKLSKMRDGPGKNAIRQKALKVLQRRKQYEAQRDQLSQQSWNMEQAGMMQDNLKNVMTTVDAMKTTTKELKKQYGKVDIDKIEQMQDEMADLMEVGNEIQESISRAYDLPEEVDEADLDAELEALGEESLFETEMGADAVPSFLQDEVAPPQFIDEPPEQAKVKEAAGGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3Y1</accession>
    <name>A0A9W9X3Y1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CCCH zinc finger and SMR domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_006255</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788781.1">
        <property type="nucleotide sequence ID" value="XM_056935857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X3Y1"/>
    <dbReference type="GeneID" id="81626106"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.110:FF:000002">
        <property type="entry name" value="CCCH zinc finger and SMR domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045124">
        <property type="entry name" value="Su(sable)-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119:SF12">
        <property type="entry name" value="PROTEIN SUPPRESSOR OF SABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="8">
        <location>
            <begin position="612"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="382"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5482809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="738" mass="80003" checksum="99D238A92E22403C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X4W5</accession>
    <name>A0A9W9X4W5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tse2 ADP-ribosyltransferase toxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000007">
        <property type="protein sequence ID" value="KAJ5483816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789086.1">
        <property type="nucleotide sequence ID" value="XM_056935618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X4W5"/>
    <dbReference type="GeneID" id="81625867"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041018">
        <property type="entry name" value="ADPRTs_Tse2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18648">
        <property type="entry name" value="ADPRTs_Tse2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tse2 ADP-ribosyltransferase toxin" evidence="1">
        <location>
            <begin position="37"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5483816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="184" mass="21834" checksum="4F1A82FD7DA19CBC" modified="2023-11-08" version="1">MFHSFLRRAQGPARGILRFPNRRAFSYVSTHQTFPASLYRFQIHRDSKLYDRAVEQDDWEYEDGVEISADGLVHPNITADCTRKQIHIFRLLTFSVSNGALFMPNTHFMQEITRRSFDNYLDNVESGQHTAEPHYLCIPKGQGLNKMLTQFYLHYRRVFNPDDWLGRHPYHEASFDDQEEWMNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X555</accession>
    <name>A0A9W9X555_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UPF0676 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_006010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000007">
        <property type="protein sequence ID" value="KAJ5483810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789080.1">
        <property type="nucleotide sequence ID" value="XM_056935612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X555"/>
    <dbReference type="GeneID" id="81625861"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000040">
        <property type="entry name" value="Chromosome 21, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="4">
        <location>
            <begin position="59"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="3">
        <location>
            <begin position="243"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5483810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="402" mass="45675" checksum="A00D378C9C160E13" modified="2023-11-08" version="1">MLKFSDLSASAPAVAKGSSLSGDSSAALEQDPYAFANLTPYVHPPETTEDLFWSDLVTLDLSDFTKPGGKQRLASQLSDAVQKVGFFYVKNFGLSQEQIDRQLTLAKNFFSLPFADKQQYSVDYEKGDYNGYRWGGYRADGSQSANNHGDNIEAYNIPKFIPELAGKYAQPPLLQRHHAEIAAFTRHLHEHIVAPLMVLFGIILELPREDLLQKMHSYDQLSDDHYRYMKYSRRTPEQHRASDGVQVKGHSDLGSLTLLFRQPVAGLQILGDDWQWRYVRPLPGTVTVNLADTLSLLTGGFFKSSIHRVVAPPRDQWGYDRLGLLYFARPHNDTVLRPLVSESPVLQRNRHLLTEGFTRPITMAEFTVAKQRMLLNPHLYEEKRDQHGDVELIAGFKDHRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X570</accession>
    <name>A0A9W9X570_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRO domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_005878</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789352.1">
        <property type="nucleotide sequence ID" value="XM_056935480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X570"/>
    <dbReference type="GeneID" id="81625729"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09242">
        <property type="entry name" value="BRO1_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09237">
        <property type="entry name" value="V_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="784"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="791"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="815"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="903"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="932"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="942"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="976"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5484082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="996" mass="110003" checksum="EADAFC683C046EA0" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X598</accession>
    <name>A0A9W9X598_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-amino-acid oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_005862</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789336.1">
        <property type="nucleotide sequence ID" value="XM_056935464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X598"/>
    <dbReference type="GeneID" id="81625713"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF16">
        <property type="entry name" value="D-AMINO ACID OXIDASE (AFU_ORTHOLOGUE AFUA_5G11290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5484066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="364" mass="39143" checksum="9ADD5E97770EF670" modified="2023-11-08" version="1">MPSNKIVVVGAGVTGLTTALLLSKDSSNDVTVIAKHMPGDTDIEYASPWAGASYLPFGAKGSQNAEYEQATWPPLRDLARNNPESGIHFQDITVQNRLKDQQTVTGKWAAELTSSSPWFKDLMPNFRNLPADQLPPGIDNAQTFTSVCINPAIYLPWLVTQCMKGGCVLKRAVLSHIADAADAHHSGVKADVVVNCTGLGSRTLGGVTDGQVHPIRGQILMVRNDPGSMTTISGSDDGSEEVAYIFPRAAGGGTIIGGTYQKDNWDPLPDPNFANRIMQRALKLDPRLVKPGQGVEGLDVIRHGVGLRPGRTDGVRIEKDQVNGVKIVHNYGHGGFGYQVSWSCAEKAARLVSETLLQKDRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5T0</accession>
    <name>A0A9W9X5T0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator-type transporter ecdD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_004838</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789634.1">
        <property type="nucleotide sequence ID" value="XM_056934440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5T0"/>
    <dbReference type="GeneID" id="81624689"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000180">
        <property type="entry name" value="MFS monosaccharide transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF6">
        <property type="entry name" value="MSTA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="30"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5484850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="534" mass="58470" checksum="ECF272253A76FB03" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5Y1</accession>
    <name>A0A9W9X5Y1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="23">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">N7539_004724</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 23">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:38584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:66037"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Membrane</location>
            <topology evidence="23">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="23"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789520.1">
        <property type="nucleotide sequence ID" value="XM_056934326.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81624575"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070867">
        <property type="term" value="C:mating projection tip membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990531">
        <property type="term" value="C:phospholipid-translocating ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140351">
        <property type="term" value="F:glycosylceramide flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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            <end position="1357"/>
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            <begin position="117"/>
            <end position="154"/>
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            <end position="1366"/>
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            <end position="112"/>
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            <end position="294"/>
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            <begin position="1392"/>
            <end position="1526"/>
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            <begin position="1"/>
            <end position="31"/>
        </location>
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            <begin position="1430"/>
            <end position="1458"/>
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        <ligand>
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        <ligand>
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        <ligand>
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        <ligand>
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        <location>
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        <ligand>
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    </feature>
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        <location>
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        <ligand>
            <name>ATP</name>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00052223"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
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            <dbReference type="PIRSR" id="PIRSR606539-3"/>
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    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAJ5484736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1526" mass="171510" checksum="A6CA5DFE4509F806" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X640</accession>
    <name>A0A9W9X640_9EURO</name>
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        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004799</name>
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    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_056934401.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608">
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    </dbReference>
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        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5484811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21364" checksum="1B277BE0E45E520B" modified="2023-11-08" version="1">MATHSEIIRPILFAVRLLLWISAVITLGLGAWIVDHVKGYRAVFPLVIAVLTTVFYIPSLFTACMKTNKGYMLPLDIVFYALWLSAFIFIAQTDNAFNEVGCASFSWTLNNACRRRNSIQAFTFLSFFWTLCGMCLEILNIYLEGRYFRKGGNIIHPEKPTQPDQYNNGAAPAVSAGQTAGVTPATAEQPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6G4</accession>
    <name>A0A9W9X6G4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent RNA helicase mtr4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_004994</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789790.1">
        <property type="nucleotide sequence ID" value="XM_056934596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6G4"/>
    <dbReference type="GeneID" id="81624845"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000003">
        <property type="entry name" value="ATP dependent RNA helicase (Dob1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="170"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="409"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5485006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1083" mass="121869" checksum="4C8A4570EBB04F60" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6P8</accession>
    <name>A0A9W9X6P8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_006000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789474.1">
        <property type="nucleotide sequence ID" value="XM_056935602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6P8"/>
    <dbReference type="GeneID" id="81625851"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000019">
        <property type="entry name" value="C6 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF15">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5484204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="724" mass="80033" checksum="C2CBB009FD691201" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X720</accession>
    <name>A0A9W9X720_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_005317</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790113.1">
        <property type="nucleotide sequence ID" value="XM_056934919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X720"/>
    <dbReference type="GeneID" id="81625168"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021132">
        <property type="entry name" value="Ribosomal_eL18/eL18-A/B/_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS01106">
        <property type="entry name" value="RIBOSOMAL_L18E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="4">
        <location>
            <begin position="2"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5485329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="184" mass="20661" checksum="D4AF1A2E0A1EADA6" modified="2023-11-08" version="1">MGIDLDRHHVRSSHRKAPKSENVYLQVLVKLYRFLARRTESNFNKAVLRRLFMSRINRPPVSLSRIASNISEAQKGKTVVVIGTVTDDNRLLTIPKLSVAALRFTATARARIEKAGGETLTLDQLALRAPTGANTLLLRGPKNAREAVKHFGFGPHSHKKPYVASKGRKFERARGRRRSKGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X777</accession>
    <name>A0A9W9X777_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_005606</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790402.1">
        <property type="nucleotide sequence ID" value="XM_056935208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X777"/>
    <dbReference type="GeneID" id="81625457"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.630:FF:000003">
        <property type="entry name" value="Polyadenylation factor subunit CstF64, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000219">
        <property type="entry name" value="Putative polyadenylation factor subunit CstF64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.70">
        <property type="entry name" value="Transcription termination and cleavage factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026896">
        <property type="entry name" value="CSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038192">
        <property type="entry name" value="CSTF_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14304">
        <property type="entry name" value="CSTF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="209"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5485618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="297" mass="32131" checksum="D02A5FACFC46B2C6" modified="2023-11-08" version="1">MAPDRSGKSVFLGNIPYNLTEEQVKDILSTAGTVTKFRLMMNPETGKPKGYGFADFADADAAASAVRNLNDYEIMGRKIRVDWPHNNEKDSVPADYSQQTQSMEQDSIPQMQQIPGAAPLPPLPPGVDVPPHLDCPNAISQTLASLPPNQLLDVLTQMKALAVADPIRATELLRQAPQLAYAIFQALLLMNLVEYQVLGSIVEQAAQTQSTPQVPPQVAPQYQQYGVPGQMGTPPVAGGPYAPPPPPTQAAPPQVPGQDELLQQVLSMPQSAIDALPPMERSQIMLLRQQLMQGGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X787</accession>
    <name>A0A9W9X787_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_005621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790417.1">
        <property type="nucleotide sequence ID" value="XM_056935223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X787"/>
    <dbReference type="GeneID" id="81625472"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5485633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="180" mass="20285" checksum="EF3100B9AAB2147C" modified="2023-11-08" version="1">MFAYDPAAIAGDRVLIGQSGQFSNQIRKRFPWVLSIGDGFRENLLFQIQSETGTLLLCETSQIRRGILPHDAMKTDSAHCERGDRVDHETFDVVESASMCENAAEEYRISPDGTVPFIFEPEFDRLVEVRGYQSLRRFADTGQRPKTPGGMTALEVLDDLESGLVGKTIEWCERHHFTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7N1</accession>
    <name>A0A9W9X7N1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_005173</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789969.1">
        <property type="nucleotide sequence ID" value="XM_056934775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X7N1"/>
    <dbReference type="GeneID" id="81625024"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="178"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="524"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5485185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="69862" checksum="A2B1EE3C653A733C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCM5</accession>
    <name>A0A9W9XCM5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_003606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790749.1">
        <property type="nucleotide sequence ID" value="XM_056933208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCM5"/>
    <dbReference type="GeneID" id="81623457"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5488716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="131" mass="14140" checksum="60863D4DF36AFBC7" modified="2023-11-08" version="1">MTRYPDPILSPSLGREIGIMIAVLGACVLTIGIYSIIWRRIQIRNQAEDLDRRKALKNRAARGPDFPSTAPAATAAAPERRIGLDTGGVYRLPMEVSGKKSEMEGGHDGSADRNGKGNENAAAARRRADLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCX4</accession>
    <name>A0A9W9XCX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791128.1">
        <property type="nucleotide sequence ID" value="XM_056933587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCX4"/>
    <dbReference type="GeneID" id="81623836"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF6">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="38509" checksum="C079C667D454C3C9" modified="2023-11-08" version="1">MTTIPVTTENLVPGLNQSRFRLTGPYGDWRDELQSQGYVVIKNAIAPARAKHYQQKALDWLTSFDTELDLNNPSTWTVDNLPFQSKVNTFNKYGVAHEKFMWDARMEPAVLEAFSTIWDTDELLVSFDALNVTLPNRADKPAQRPWPHVDQSPLRRGLHCVQGIINLSHAGPEDGSLIVLPRSNTATEHFFDTETDPSTWESKDIRFISESEMKWFEARGMNPLKVMAEPGDLLLWDSRTVHWGGEPTAKSDTIRTVIYVSYSPAKWARSEELERKREAFESFHATTHWAHDNIVPREKEAYLPDGSWDPRNRSEPLEKPERSKKLLQLAGVESYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDC3</accession>
    <name>A0A9W9XDC3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3 14">2.4.1.258</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dol-P-Man-dependent alpha(1-3)-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_003848</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyltransferase ALG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3 14"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790991.1">
        <property type="nucleotide sequence ID" value="XM_056933450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDC3"/>
    <dbReference type="GeneID" id="81623699"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5488958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="416" mass="46580" checksum="15A745DAE5D73A6E" modified="2023-11-08" version="1">MSNPWIKFVRTALTHPKHSPWIIALLFLGDAALCALIIWKIAYTEIDWTTYMQQISIYLAGERDYTAIKGSTGPLVYPAAHVYIYSLLHDLTDGGHDILMGQILFAGLYLATLIVVFACYRRVQVPPYLYPLLVLSKRLHSIYMLRMFNDGIAALAMWIAIYLCMRQKWTAGIAIWSLGVGVKMTLVLLVPGIAVVTLLNLGRGRSIALGVMAILIQVLISIPFIRENPLGYLSKAFELSRQFMFKWTVNWRFVGEETFLSKEFSLGLLVLHVSLLALASAVWVKPSGTNVVRFLQDSIQGRHPPMSLSGSFIMTVLLSSLTIGMLCARSLHYQFFSYLAWATPFLLWRAGFHPVLIYGLWAMQEWAWNVYPSTDLSSLGVVVLLAVQVFGVIANGIRDTESKRGAAALRAKGRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDN9</accession>
    <name>A0A9W9XDN9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790996.1">
        <property type="nucleotide sequence ID" value="XM_056933455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDN9"/>
    <dbReference type="GeneID" id="81623704"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5488963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="67" mass="7645" checksum="4EF9E644E34AAE83" modified="2023-11-08" version="1">MNGGEKVAEEALRLQRGTAGIVRDEECELNGDAGEERREEKATVVARDQKRYKIDSRRVWKVEAGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEN6</accession>
    <name>A0A9W9XEN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_002403</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791965.1">
        <property type="nucleotide sequence ID" value="XM_056932006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEN6"/>
    <dbReference type="GeneID" id="81622255"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5490836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="295" mass="31737" checksum="92E4FCDAB2522CA3" modified="2023-11-08" version="1">MSSQPNNAAFKLENLFSMKGKVALVTGGGSGIGLMATQALAVNGAKVYITGRTKEKLDRVVEVYSKDIPGEIIAIPADVTSKESIQKLVDEISAKESKLHILINNAGISSTKQDVEKSSPEELKQELFHHTSSISDWEEVMRTNVMQIFFVTTAFLPLLNKGTEQTPGWSSTVLNITSISGIVKVSQHHFVYNTSKAAAIHLTKMLAHEIADSGVKIRVNNIAPGVFPSEMTAKESDDKQKSALEKEKFEGKVPAGRPGKDEDMASAVLFATSNQYLNGQTVVVDGGYVLAAGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XET2</accession>
    <name>A0A9W9XET2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791976.1">
        <property type="nucleotide sequence ID" value="XM_056932017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XET2"/>
    <dbReference type="GeneID" id="81622266"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01709">
        <property type="entry name" value="RT_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="909" mass="104514" checksum="03A779F1EA709320" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFB1</accession>
    <name>A0A9W9XFB1_9EURO</name>
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        </recommendedName>
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    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
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            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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            <end position="133"/>
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            <end position="343"/>
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            <end position="762"/>
        </location>
    </feature>
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            <end position="235"/>
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        <location>
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            <end position="273"/>
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            <end position="290"/>
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    </feature>
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            <end position="382"/>
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            <end position="421"/>
        </location>
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            <end position="470"/>
        </location>
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        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="568"/>
        </location>
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        <location>
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            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="597"/>
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            <end position="640"/>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="762" mass="83280" checksum="26B678A190CE90BD" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFI9</accession>
    <name>A0A9W9XFI9_9EURO</name>
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        </submittedName>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5491319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFT5</accession>
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            <fullName evidence="2">polynucleotide adenylyltransferase</fullName>
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        <name type="scientific">Penicillium diatomitis</name>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
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            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056932621.1"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Topoisomerase family protein Trf4"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="7">
        <location>
            <begin position="277"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="6">
        <location>
            <begin position="472"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="610"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5491451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="650" mass="72967" checksum="DB50502C281AF79E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGF7</accession>
    <name>A0A9W9XGF7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_002885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792447.1">
        <property type="nucleotide sequence ID" value="XM_056932488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGF7"/>
    <dbReference type="GeneID" id="81622737"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000098">
        <property type="entry name" value="Protein phosphatase 2C, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF589">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="57"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5491318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="464" mass="50886" checksum="1FC8814DD01F8D25" modified="2023-11-08" version="1">MTVVRIPLRSAKHHFGAVTARGTRPANEDTYQAGVIDIPAFAKRPPASLTINRIKRSASSTEPRESRAADTANGDPQVFYFGIFDGHGGSECSTFLQDHLHEYIQNSAAEFEVKSSLCKLQQQVGNGPTAVDSPNSSALPVMQEANRQRIGDLEKNLVQNWRRLVGGYFKRFKPSHFAYHDSDVPAEDSQIQGHVTIEEVLEYAFLRTDLDFVKAQAAKRDDDLVLAEKPLNEDEILYSPSLTRTPKIGGRSRFKGGSTGSVAMISTPTSTPFWHPTGSSSLIVAHVGDTRVLLCSTIDGQAIPLTSNHHPSSPIEAGRLRRYAATFVTDSFGEERMSGLANTRAFGDVQSKRIGVSAEPELCRVELGPAEFSFMVLVSDGISGTLQDQEIVDIVKEARTPEQGARDVVSFATEVTKEGDNATCLVVRLGGWERRLEGGVGSLGTKESRDWRREDATDPRRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGK4</accession>
    <name>A0A9W9XGK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_001364</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792998.1">
        <property type="nucleotide sequence ID" value="XM_056930967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGK4"/>
    <dbReference type="GeneID" id="81621216"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08284">
        <property type="entry name" value="FDH_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF2">
        <property type="entry name" value="DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="13"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5492618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="356" mass="38829" checksum="FDB241885A5C73CD" modified="2023-11-08" version="1">MANPSTMQAVVFKAPYKVAVEQRPIPHVQDPEDVVVKVGYTALCGSDLHTYRGIEPSPEGPIMGHEFMGEVVEIGSAVRTLKKGDRVVSAFTTSCGKCFYCKQSYSSRCEKSTLFGCEKLDGSQAEYVRVPNAEGTVIKAPEGVDEKYLVLMADIFPTGYFAAYNAFKNSTPEQIAEQTVVLIGCGPVGLCGLINALEYKPKHLLAVDSVPSRLELAKSLGAEPWNFMTDRAGLDKRVQELTNGRGADAVIEVVGLSPALRTAYDLVRPWGVISSVGVHNAEIPWNGADAYDKNLTVQMGRCPVRSVSDKALEVLKKNQHKLGFMTENVMPLSQAVEAYEIFNAMKVQKVVFIADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHJ9</accession>
    <name>A0A9W9XHJ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">agmatinase</fullName>
            <ecNumber evidence="5">3.5.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003304</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>agmatine + H2O = urea + putrescine</text>
            <dbReference type="Rhea" id="RHEA:13929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="3.5.3.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792865.1">
        <property type="nucleotide sequence ID" value="XM_056932906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHJ9"/>
    <dbReference type="GeneID" id="81623155"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019627">
        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000006">
        <property type="entry name" value="Agmatinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040962286" description="agmatinase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5491737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="424" mass="46050" checksum="C93A0EC18DC86BC5" modified="2023-11-08" version="1">MPAWKSLVSVLALASTAVSCAHHGDNEVVPEHEREELLKKWDQEWSFSGIASFAHLRTVKCLVEPSENYDIAVIGAPFDTAVSYRPGARFGPRAIRAASARQMSGTSYNTRAGINPYNSWAKITDCGDIPITPFDNGLAERQMYEAFLELGSRKIVNAAPSTKSKNKKDVSIGARHPKLVTLGGDHSVALPALRALYKIYQKPITVLHFDAHLDTWNPVRYSAYWQSEQTQFNHGSFFHKASREGLICNSTSAHAGLRTRLTGVDDGDYTTPGPEQGFIRIHADDIDELGPMGVVEKIMSRIGLDPEQPVYLSVDIDVLDPSTAPGTGTPEPGGWTTREFIRILRGLEKLNLVGADIVEVSPAYDNKGETTALAAAQVVFEIITSMVKSGVDAQLGGWYGRREDGSGGVGVVEEAPATAGKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHK6</accession>
    <name>A0A9W9XHK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793526.1">
        <property type="nucleotide sequence ID" value="XM_056931495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHK6"/>
    <dbReference type="GeneID" id="81621744"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="800"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="533"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5493146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="826" mass="92689" checksum="CBC1962E57926352" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIK4</accession>
    <name>A0A9W9XIK4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calcium/calmodulin-dependent protein kinase cmkB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_001770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793404.1">
        <property type="nucleotide sequence ID" value="XM_056931373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIK4"/>
    <dbReference type="GeneID" id="81621622"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000257">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000153">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="14"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="332"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5493024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="400" mass="45005" checksum="2956FDFBEBEDFEFD" modified="2023-11-08" version="1">MAQPQKPQIQPCRYKTGKTLGAGSYSVVKECVHIDTGRFYAAKVINKRLMAGREHMVRNEIAVLKKVSMGHQNILTLVDYFETMNNLYLVTDLALGGELFDRICRKGSYYESDAADLIRAVLSAVAYLHDHGIVHRDLKPENLLFRTPEDNADLLIADFGLSRIMDEEQFHVLTTTCGTPGYMAPEIFKKSGHGKPVDIWAIGVITYFLLCGYTPFDRDSNLEEMQAILAADYSFTPLEYWRGVSQEARNFINRCLTIDPQKRMTAHEALQHQWVNPPYDLTTIGSGEDLLPTVKKNFNARRTLHRAIDTVRAINKLREGGGFMMDGVMSIDPKPERVNGQEVVEESHQSGAPSSKGGDGDLMQIDSRGNARGQTEEQIREQERRVKDMVAGLWSRGHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XL19</accession>
    <name>A0A9W9XL19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_000072</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793969.1">
        <property type="nucleotide sequence ID" value="XM_056929676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XL19"/>
    <dbReference type="GeneID" id="81619925"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5494956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="23641" checksum="93B2748BCA69B865" modified="2023-11-08" version="1">MSSSTSKPAPTVLVALSAEAVDDLIYDARAGDLEALNADIATLAAQHNCPESHIVASVIDMEDESAGGTGSCVLHFPAANGNSEILNALLQKLSPLDAAQRTAFVNHPNHSGNTPLHWAALNTHLECVKALVEAGADVALKNDAGHDAMFLAERAAWSAGAEEDGEAAENADEPQEIEMTIGEEEQGQQQQADAGEMSAGRQVVEWLLSSEKAAGLESSATEAEKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XL43</accession>
    <name>A0A9W9XL43_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SVP1-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_000085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793982.1">
        <property type="nucleotide sequence ID" value="XM_056929689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XL43"/>
    <dbReference type="GeneID" id="81619938"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5494969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="361" mass="38849" checksum="CD2EFAD22B2B131F" modified="2023-11-08" version="1">MRTLVSSRSLEVSLPITKASVRLDVTHHQPPGIADFNAGIGVVEMLGQSNYLAIVGGGRNPKFPQNKLVIWDDAKQKAAIILEFRTSVLGVRLSKSKIVVALLNSIHVYAFSTSPKKLSVYETSDNPLGLACLGQKKLAFPGRSPGQVQLIELETGNISIIPAHSSPLRAMSLSPDGELLATASEAGTLVRIFSTANCTKLAELRRGVDHAIIFSLAFSPSNNLLAVTSDKSTLHIFDVPHPHLPHRAQSPASSLEESASQKWGILGRLPLLPRVFSDIYSSASAHFEIGDEAGSGTSYGSSPGTSIGRRPAKGVIGWIDNHTLLVLGAGQDGRWEKFILRNGDDGRRYCTRDGWKRYLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XL56</accession>
    <name>A0A9W9XL56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pre-mRNA-splicing factor isy1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_000104</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ISY1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794001.1">
        <property type="nucleotide sequence ID" value="XM_056929708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XL56"/>
    <dbReference type="GeneID" id="81619957"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5494988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="253" mass="28787" checksum="0A4356279E1D5353" modified="2023-11-08" version="1">MARNSEKAQSMLFRFRAQQAADMGIIDIGRTRRPKNITSVDSIPTCERWRGQVLKEISRKVSRIQEPSLSDYQIRDLNDEINKLMREKWAWEMQIRNLGGPNYMRGSGRVYDDEGREIPGGGKGYRYFGRARELPGVKEMFEAAARRGKGPPEEEEEGTGTGRGGDIATKKVNANYFGYGLDEEDGTLLAYEKQKEKEAVEGLRVQGDDDAEDGWEPLPGDSGDGVEWRLPSLEEVQEELVNRRRERLLQKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XL69</accession>
    <name>A0A9W9XL69_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ras-related protein RSR1</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_000147</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794044.1">
        <property type="nucleotide sequence ID" value="XM_056929751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XL69"/>
    <dbReference type="GeneID" id="81620000"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000114">
        <property type="term" value="P:regulation of establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000631">
        <property type="entry name" value="Ras small monomeric GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="162"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5495031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="198" mass="22522" checksum="18E887727B01C3E8" modified="2023-11-08" version="1">MRPQREYHIVVLGAGGVGKSCLTAQFVQNVWIESYDPTIEDSYRKQIEVDGRQCILEIELYMKQGQGFLLVFSITSMSSLNELSELREQIIRIKDDEHVPIVIVGNKSDLEEDRAVPRARAFGLSQTWGNAPYYETSARRRANVNEVFVHLCRQIIRKDLQEPSGGVDTTRKRDGPSRGDRKRDKGSGGRRRSPCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XL95</accession>
    <name>A0A9W9XL95_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_000179</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794076.1">
        <property type="nucleotide sequence ID" value="XM_056929783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XL95"/>
    <dbReference type="GeneID" id="81620032"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040782658" evidence="3">
        <location>
            <begin position="24"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="16"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5495063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="134" mass="15023" checksum="346784938D8BF9A7" modified="2023-11-08" version="1">MELSTLLILAAVFIAFRIYQARSAASTPIMSHGKVSNIDNEVIFKALVSSGPVLVDFYATWCGPCKAVAPKIGEFSEKYEKIRFLQVDVDKMRGTAQQFNVTAMPTFVMMKDGQEVQRVRGADLKSIEEWLQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLG5</accession>
    <name>A0A9W9XLG5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794162.1">
        <property type="nucleotide sequence ID" value="XM_056929869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLG5"/>
    <dbReference type="GeneID" id="81620118"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="79" mass="8358" checksum="13405C9DAD2696DE" modified="2023-11-08" version="1">MSEMSSNGNQGQLAKVASSPSEETWISTTWRALQGIFVSDAPSQEEDADAVVGWVGGRNGRRRCRSIGGRHGVAEPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLH0</accession>
    <name>A0A9W9XLH0_9EURO</name>
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        <recommendedName>
            <fullName evidence="5">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_000328</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Rad9_Rad53_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
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            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5495212.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1490" mass="162840" checksum="F38CD122160321AF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM36</accession>
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        <submittedName>
            <fullName evidence="10">Winged helix-turn-helix transcription repressor DNA-binding</fullName>
        </submittedName>
    </protein>
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    <organism evidence="10 11">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen J.L."/>
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            </authorList>
            <dbReference type="PubMed" id="36726175"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2 10" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
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            <end position="211"/>
        </location>
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        <location>
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        </location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="483"/>
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    </feature>
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        <location>
            <begin position="555"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5495477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="661" mass="71966" checksum="35AA79AA6AA1F686" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMJ4</accession>
    <name>A0A9W9XMJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_000376</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794273.1">
        <property type="nucleotide sequence ID" value="XM_056929980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMJ4"/>
    <dbReference type="GeneID" id="81620229"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000679">
        <property type="entry name" value="Thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="10">
        <location>
            <begin position="17"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5495260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="232" mass="25631" checksum="1A0E0F880721D182" modified="2023-11-08" version="1">MSSSAERSARRGALIVVEGLDRAGKSSQCEMLQTYLAERGHDVKYIRFPDRTTPIGKLIDAYLRGSADQNDHSIHLLFSANRWELAKSMQRDIAAGISIVVDRYSYSGAVYSAAKANPTLSLDWAWQPEIGLPQPDLCLFLNISTEAAAQRGGFGEERYENEKMQTRVREIFRALFDRQDKVCVIDAGRALDEVAKDVHIAVEKCFVNSSRNEPLGTLGPLAPRAGSVPSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMS0</accession>
    <name>A0A9W9XMS0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase MPR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794854.1">
        <property type="nucleotide sequence ID" value="XM_056930561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMS0"/>
    <dbReference type="GeneID" id="81620810"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE ACA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="110"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="267" mass="28604" checksum="56BF847189E89647" modified="2023-11-08" version="1">MPSILEDPSTRIPPPPSHTMAASSLKPRPTTLPKASNAGLTLYPIANGAENVPRDLVRFLHAEFSAEIVRGGTYPMEQPMELDQFASYWFGTFAVVAVLDLDEGEDGEKAKVDEAEAGAGAGAGAGGLREGRNWEKVCLGTFYIKPNYPEGVQNAEPRQFALVSGGGTTGSITVRRCSHICNAGFLTTTAARGKGVGQQMGEAYLHFAPQLGYKYSVFNLVFANNPASIRIWEKLGFSVIGRVPKAARLANSEELVDALIFGRELGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMU1</accession>
    <name>A0A9W9XMU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_001034</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794931.1">
        <property type="nucleotide sequence ID" value="XM_056930638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMU1"/>
    <dbReference type="GeneID" id="81620887"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF7">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5495918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="590" mass="63631" checksum="5EC67060158EA6CD" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMY1</accession>
    <name>A0A9W9XMY1_9EURO</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name type="scientific">Penicillium diatomitis</name>
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            <authorList>
                <person name="Petersen C."/>
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        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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            <strain evidence="2">IBT 30728</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495455.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
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    </evidence>
    <sequence length="308" mass="33902" checksum="64E177DF2E4195B0" modified="2023-11-08" version="1">MAVKRRKDTAVVARLSDEKEPSPPPVNDAQDIFRKYFEAQFEPIETSASSKRKSDALSSGDEDIDEEDEEDEDLSEVDSDWDGVSGDESDEEAEVEVVEHKDANLSASDLMDKKAYKAFMSAKPPTSADEKKKTAQVTKKDDSEDDAHEAMNLKNDLDLQRLLRESHLLESASDLAPTGKNRLKALDLRMQDLGAKESLYKQKNMPDAFRKGIKAKAVSKDEKRRREAKENGIILEKPSKVAKTDNKRRERGVGGSSIGKFSGGTLNLSKQDLEKMQSSRGRGGRGGRGGRGGRGGRGGRGGAKRGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="298"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9W9XNB7_9EURO</name>
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    </gene>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00388">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="474" mass="54240" checksum="9047AA206DA8DC14" modified="2023-11-08" version="1">MVAEKLTVRNSTSTPIILRRIERFESPQDSNAGDNIALFARNFTRVLTNTTRIAEPVKAISEATRPFEDQNELDVRIDPFTTNQTDRRAFVHSDKERMRLTFEVEGERHTIQVPVPTAESATMKCESENSKHRLTGVYLTNESYLAIFSSANLNAWMHELRDDIRLPGLSIPGTHNSPTCYVAPPSVRCQAVGPKEQLQNGVRFFDIRVQPQYPEDLDKDDLILVHSVFPISLTGNKYFRDLMKEVNEFLDQNPSETVIMSLKREGPGNATDEQLAEILSRHYIRPDSRWWTTPWPPTLGQVRGKVVLVRRFSIPDELKKQHDTFGWGIDGCGWEDNHPNANCPSGHLCIQDFYEVQESTNIDNKINYVRQHIDRASRHSHPFGEIPNPDKGRECPFYINFLSASNFWRPNTWPEKIAAKVNPATVDYLCRRPYDENGDSSTGILVTDWVGLDGDWDLVRCTVGMNAKLRLREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XP72</accession>
    <name>A0A9W9XP72_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Alternative oxidase</fullName>
            <ecNumber evidence="17">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">N7539_000960</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="16 17">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the alternative oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="17"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794857.1">
        <property type="nucleotide sequence ID" value="XM_056930564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XP72"/>
    <dbReference type="GeneID" id="81620813"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01053">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.140:FF:000002">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005229">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="14 17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
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    <feature type="binding site" evidence="16">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
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    <feature type="binding site" evidence="16">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005229-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ5495844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="357" mass="41503" checksum="7779441DCA899159" modified="2023-11-08" version="1">MNSLATISRVRPLRATARPQSVLYFAMRTCSTGSSTWNRSSCLVPQRSSPVFYTAKRPISSTPQPQIKEYFPPPENPAVKEVDSAWAHPVYTEAQMQNVRVAHREARDWSDWVALGTVRFFRWGMDWITGYKHPGPGQQLPARFKMTEQKWLTRFVFLESVAGVPGMVGGMLRHLRSLRKMKRDNGWIETLLEEAFNERMHLLTFLKLAEPGWFMRLMVLGAQGVFFNGFFLAYLISPRICHRFVGYLEEEAVLTYTRAIKELESGHLPEWNQLEAPEIAVQYWKMPEDKRTMRDLLLYIRADEAKHREVNHTLSNLNQAIDPNPYQTKYQNPVRDHPSRGIENLKATGWERKEIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ64</accession>
    <name>A0A9X0BJ64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_009493</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ELOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785810.1">
        <property type="nucleotide sequence ID" value="XM_056939088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJ64"/>
    <dbReference type="GeneID" id="81629338"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000001">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5466764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="126" mass="13616" checksum="505F31111F4DA1AE" modified="2023-11-08" version="1">MLTANSKSQGKRKKSSRTPQGPRKREPLATTFPCLFCNHESSVIVKLDKKLGLGDLSCKMCGQKFQTGINYLSAAVDVYSDWVDACDAVAKDTANQYDGPVGSRGTGKDSLASAGHGESYEDEDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ84</accession>
    <name>A0A9X0BJ84_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785916.1">
        <property type="nucleotide sequence ID" value="XM_056938539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJ84"/>
    <dbReference type="GeneID" id="81628789"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="373"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5469326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="410" mass="45520" checksum="92EC2D623A13F4B5" modified="2023-11-08" version="1">MLGQTQRPAVRAIGRVRCQVKPRASRPSRFQSTSSGPSSSTRTGTGTNAALAGGLAGGATAALVGYGIYSFSGAKSFVDTNRQAKQYLEQAKQKIAEAAPEPNESYNWFKKTAKRYAVFIPGARDYVDTAFRDLDQIKEKHGDDFEKIIQDAYQELSDVSSRGSFDSDTAFSAFHVLQKHLDRLMDLAGDVSDQILDNHPQVKEKIGGSYQQLKEMGEAYGPQAKEEVNKTWNQITDVIKKGASVDAIAEVKKLIDEKKQKLQKLGDEAWQKGLEQSRQQLEKNPKLKSLVEDNADALKKGNFSDLWKMIQESASSGNTEQVEKFVKDKVDQAKSHGFGDMDKWLQAIPGGSNIIPQLQSLQQVAQKKGGEAEKVLKETFEELQDLLKKRKEQVEKIADDAKEESKNETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ88</accession>
    <name>A0A9X0BJ88_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">N7539_008857</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785829.1">
        <property type="nucleotide sequence ID" value="XM_056938452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJ88"/>
    <dbReference type="GeneID" id="81628702"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF36">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 15" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040904807" description="AA9 family lytic polysaccharide monooxygenase" evidence="17">
        <location>
            <begin position="17"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="18">
        <location>
            <begin position="318"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="275"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ5469239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="358" mass="37151" checksum="61EC1B252DC17A79" modified="2023-11-08" version="1">MYKALAILMLADLVVGHGHISNIVVNGVSYQGWDIGSFPYLSNPPVVAVWGTPNTGNGFISPYMKLMLCEPASYDSSDIIYHMDATNAKGHIVVAAGDKINLQWTTWPDTHHGPVITYLADCGASCETVDKTTLKFFKIDAVGLVDESTPPGTWADDQLIANGNSWMVEIPPKLAPGNYVLRNEIIALHSANNADGAQNYPQCFNLQVTGSGSDKPSGVLGTDLYSPTDPGILVNIYQSLASYTIPGPAPYTGAVSIAQATSAITASGTPITGSGAVPTTTTAGSGPSTTKTSTTTLVTKTTTTKVPTTTGSGSGSASTQTVYGQCGGLSWNGPTACAAKATCASYNPYYSQCVPSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJL4</accession>
    <name>A0A9X0BJL4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_009217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786189.1">
        <property type="nucleotide sequence ID" value="XM_056938812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJL4"/>
    <dbReference type="GeneID" id="81629062"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053267">
        <property type="entry name" value="Verrucosidin_biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5469599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="255" mass="28819" checksum="60C16B7C39FB7592" modified="2023-11-08" version="1">MSLSTRDSAQDYWTNMGTGNMDLDNHLSEDQKYSSTTCVFPDTAHTSTTRESSSPILPESGVIDIGINSAGLPSHDQLVDSNHVDTTGWYTHYDNCVQFFINTSQHTPAVQGIAAFLNIRLPYQRSFSALSQDQQDFSSSETHQPNRPYVSLRPYMRRMIVTAQDTPPTMSAFFGPDWPAGVGIILKQERLNYLFTAKSGGWAQTKAAYDILPDEQTPFLRPLRDPKEEELRVAEARWSEWLAMEDWMVGARSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJL6</accession>
    <name>A0A9X0BJL6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycosyltransferase family 28 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_009349</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786321.1">
        <property type="nucleotide sequence ID" value="XM_056938944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJL6"/>
    <dbReference type="GeneID" id="81629194"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="5">
        <location>
            <begin position="60"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="6">
        <location>
            <begin position="279"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5469731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="752" mass="83919" checksum="37DBD2D9BD592715" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BN12</accession>
    <name>A0A9X0BN12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_008261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786953.1">
        <property type="nucleotide sequence ID" value="XM_056937861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BN12"/>
    <dbReference type="GeneID" id="81628111"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF36">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="464"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="37"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5475195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="481" mass="51493" checksum="CE9F9113FC8073FD" modified="2023-11-08" version="1" fragment="single">MSTVKGSSDIVKSDPHLDRLGRARPESLPGQWSELGFCFAVALSQILAEFYVTGSSVLLPTLIKELEIPASSTIWPATALSLAVTSTLLIFGRLTDMYGGYVVYNGGAILLTVTSILCGVSQSALMLIICRALQGLALGALLPSGLMILGSTYRPGPRKNLVFSIYGACAVLGFFLGFFISGLCGQFLSWRWFFFIGAILSAVMVAFSLFCVRNDYQEKKSAGVRMDWVGLALSVSGATLVVFALAYGSHAPQGWKTPYIPILFAIGVVLLCLMAYFEGWVVSNPLLPGDIFQVKSMTPMLLALLCLYGSMGIFLIFGVLYMSAFMGASPLQIVAWTAPMAVGGLFLSITGGLVLHKLSGTLLMIISCCGYVGCALLFALVPLGGNYWAFIFPAMICATIAVDICFSLANVFVTTSLPQARQGLAGALIYCTLHMGIAVVLGFADIIESQTKHLGQWKSYKSVFWFQVGLSVVGLLIILGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNG4</accession>
    <name>A0A9X0BNG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787267.1">
        <property type="nucleotide sequence ID" value="XM_056937402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNG4"/>
    <dbReference type="GeneID" id="81627651"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037652">
        <property type="entry name" value="Mim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19117">
        <property type="entry name" value="Mim2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="130" mass="14401" checksum="DCFE9FCECF3D4456" modified="2023-11-08" version="1">MATPPPSSSDSNPSFSMSAYMMPSQQDSFASDSDLEDDVASLPSVSTSDSDMETLSDDYSDAEAEWRESIEQLELMLTMVLVPFVGKYLGRRCAYWSWTRFMQWKYPVEVTITNPGLFKGAGVIEAAATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNL6</accession>
    <name>A0A9X0BNL6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787105.1">
        <property type="nucleotide sequence ID" value="XM_056938013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNL6"/>
    <dbReference type="GeneID" id="81628263"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="193" mass="21661" checksum="34A84D8FD8DA8291" modified="2023-11-08" version="1">MTRSTDELVDVKPMWPKLGELLTHGDDVKRESWTSVDQDYLHRSGFWLRFSGRWDGFALWRSGARRGAVVLKSERVIHSDGASEQLAQRADKLPGDAELGVSAEAELVSTPPVGRHSFLGHHSRREGLGVCATFPWQVASPTDDPELRDKRESFGSPESGHSRNGGTVQTCPTPVRVWGRRTRWDVETRREST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNW5</accession>
    <name>A0A9X0BNW5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoside transporter family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_007419</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787819.1">
        <property type="nucleotide sequence ID" value="XM_056937020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNW5"/>
    <dbReference type="GeneID" id="81627269"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF88">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5477275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="49136" checksum="28A721A97DB4D124" modified="2023-11-08" version="1">MDRIRRMFTDHVSYEPLDDSPEVDGGEAEVDHDRVQGRFSRLEYGVFFLLGISMLWAWNMFLAAATYFHSRFESDEWIAGHYQPSILTVSTLTNLGTVWAFAKIQKRLSYPARITISLLVNCAVFTLLAFSTVVLKNIPVRAYFGFLMVMVFGASFAAGLNQNGVFAYVAGYGREEYTAAIMSGQGVAGVLPCIAQIVSVLAVPRSKGDGQTQDGGQGSSSRSAFIYFFTATGVSVLTLIAFLYLLRHRPSPRRVTTGEDEDASLIGHVKDKSVGLWTLFKKLRSLSIAVFLCLMITMMFFPVYTSRIVSVHDSEKSRVYDSNVFIPLAFLFWNVGDLAGRVAVSYPGLSLAHRPKVALTLTVARVVFVPLYLLCNIDGSGAAVQSDVFYMVVVQLLFGVTNGYLASSCMMGASVWVSPDEREAAGGFMSMMLVAGLAAGSFLSFLVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BP28</accession>
    <name>A0A9X0BP28_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">26S proteasome subunit rpt4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_007346</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787746.1">
        <property type="nucleotide sequence ID" value="XM_056936947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BP28"/>
    <dbReference type="GeneID" id="81627196"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000008">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="170"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="9"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5477202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="393" mass="43990" checksum="35A4EB7F1D00A557" modified="2023-11-08" version="1">MNGGVDPEREQALEDYKNSLLELREWEAKLKGLRMGIKDLQHEFDVSEDNIKALQSVGQIIGEVLKQLDEERFIVKASSGPRYVVGCRSKVDKAKLKQGTRVALDMTTLTIMRMLPREVDPLVYNMSLEDPGSVNFAGIGGLNDQIRELREVIELPLKNPELFQRVGIKPPKGVLLYGPPGTGKTLLARAVASSMETNFLKVVSSAIVDKYIGESARLIREMFGYAKEHEPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQLDGFDYLGKTKIIMATNRPDTLDPALLRAGRLDRKIEIPLPNEVGRLEILKIHSSTVQLEGEIDFESVVKMSDGLNGADLRNVVTEAGLFAIKDYRDAINQDDFNKAVRKVAEAKKLEGKLEYQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BS84</accession>
    <name>A0A9X0BS84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein mL59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788113.1">
        <property type="nucleotide sequence ID" value="XM_056936178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BS84"/>
    <dbReference type="GeneID" id="81626427"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037507">
        <property type="entry name" value="Ribosomal_mL59"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040922">
        <property type="entry name" value="Ribosomal_mL59_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18126">
        <property type="entry name" value="Mitoc_mL59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL59" evidence="2">
        <location>
            <begin position="14"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5480683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="198" mass="22678" checksum="3C57D7C30396B4B4" modified="2023-11-08" version="1">MSSIAQNVGALPTRLRNFFARYPPQVYSSLVAPRPTPPEAETSADQALPSPYTPDRDAKGAHRPDPEDFSPSRSLLFNDPKNPNPFLPRKIFNSKKWMGPRYGLRQQADLVKLAIKYNVEPLLPPGPKSTEYKAAKLAERGLRIKGTGIGQKVKGHKWERTMEAKLEDRRKAMIEMPEMIRLWKQRGHGRGWRQWPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSA5</accession>
    <name>A0A9X0BSA5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase II transcription factor B subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_006814</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788350.1">
        <property type="nucleotide sequence ID" value="XM_056936415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSA5"/>
    <dbReference type="GeneID" id="81626664"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2610:FF:000001">
        <property type="entry name" value="General transcription factor IIH subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00625">
        <property type="entry name" value="tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="10">
        <location>
            <begin position="413"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5480920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="481" mass="54032" checksum="41DD0C5D0BEDF8B0" modified="2023-11-08" version="1">MAASTSRPLEYLEGLPGMTFNKLYQQPSTALAIFRRMLPDLAKCFVMALLYLKDPLPTHDLELWVKAESKKQRDNALSILGRLHILSKTLTSENVSAYMVTNPFADSLRKALTGSEDSQSFGVFSQHRNEHRKSISDLDEYARRQWEGVLGYMVGTEYLKDSGHPEVSLSKGVKQLLQAGHLVEIYERRTEITKDGFAFVLQDVNTQVWHILILYVESAEAIGMDSVEVLSFLFLLSSLELGQSYEKKYLSPVQLRTLADLADFGIIYQRSPDAPRFYPTRLATTLTSDSSALSSTVGSSLNGPAGPQGASGTGSGFIVIETNYRLYAYTSSPLQISLISLFTTLKYRFPNLITGKITRQSVRRAIDMGITADQIISYLHTHAHPQLRKHNAGHSTSNTAGIPPSILPPTVTDQIRLWQLERDRLRATSGFLFKEFTTLQEYQAPCQYAAEIGVLVWKSDRKRMFFVTRHEQVAAFLRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSC1</accession>
    <name>A0A9X0BSC1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypoxanthine-guanine phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_006843</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788379.1">
        <property type="nucleotide sequence ID" value="XM_056936444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSC1"/>
    <dbReference type="GeneID" id="81626693"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000033">
        <property type="entry name" value="Xanthine phosphoribosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363:SF1">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5480949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="204" mass="23043" checksum="82B71E6D0F3935B2" modified="2023-11-08" version="1">MVQKYYVTYNQVHKLCQQSADAILKQFRPHLMIAIGGGGYVPARILRSFLKSPGEPNIPIQAIGLSLYEDLGRGDAEEAIGTKVTRTQWLDLSSLEMANLIGKNILIVDEVDDTRTTLEYAVRELEKDVLEAQKQLGREGEKTNFSVYVLHNKNKPKKGSLPTDMMEDGRYHASVTTDDVWICYPWEAKDIDEHDALAKEHPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9X0BSN9_9EURO</name>
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        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788246.1">
        <property type="nucleotide sequence ID" value="XM_056936311.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81626560"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5480816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="663" mass="74171" checksum="81A85A022BE92298" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSQ6</accession>
    <name>A0A9X0BSQ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_006228</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3RF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788754.1">
        <property type="nucleotide sequence ID" value="XM_056935830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSQ6"/>
    <dbReference type="GeneID" id="81626079"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052256">
        <property type="entry name" value="E3_ubiquitin-ligase_CHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079">
        <property type="entry name" value="UBIQUITIN LIGASE PROTEIN CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="19"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="871"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="96"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="266"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="778"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="814"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="783"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="842"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5482782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="934" mass="103662" checksum="2ECB9641103FA5E2" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSQ7</accession>
    <name>A0A9X0BSQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_006906</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788442.1">
        <property type="nucleotide sequence ID" value="XM_056936507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSQ7"/>
    <dbReference type="GeneID" id="81626756"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13292">
        <property type="entry name" value="PH_Osh1p_Osh2p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000281">
        <property type="entry name" value="Oxysterol binding protein (Osh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000008">
        <property type="entry name" value="Oxysterol binding protein (Osh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3490:FF:000010">
        <property type="entry name" value="Oxysterol binding protein (Osh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000061">
        <property type="entry name" value="Oxysterol binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="300"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="393"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="512"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="744"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="796"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5481012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1254" mass="140147" checksum="1B4B9EC07D585620" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSY1</accession>
    <name>A0A9X0BSY1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">N7539_007010</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788546.1">
        <property type="nucleotide sequence ID" value="XM_056936611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSY1"/>
    <dbReference type="GeneID" id="81626860"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16489">
        <property type="entry name" value="mRING-CH-C4HC2H_ZNRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="20">
        <location>
            <begin position="336"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="633"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="53"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="190"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="294"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="392"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="459"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="483"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ5481116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="675" mass="72835" checksum="88F18C834D318CFA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BTR8</accession>
    <name>A0A9X0BTR8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein ecm33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_006092</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000007">
        <property type="protein sequence ID" value="KAJ5483892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789162.1">
        <property type="nucleotide sequence ID" value="XM_056935694.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81625943"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LRR_5"/>
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    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Rcpt_L-dom_sf"/>
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        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0964">Secreted</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="399"/>
        </location>
    </feature>
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        <location>
            <begin position="340"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5483892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="399" mass="41782" checksum="36BF676B372B73AA" modified="2023-11-08" version="1">MPFVKYILPALAASQLAFASSDPCGDAKVQNQGDADALASCGTIKGDITIAKSYTGTLSFSGFENVTGSITCDGGENITDITADKIIKIGKEFNLNGLTRLTTLAFGNLNNVGSISWNALPKLQSLNFNAGVTQAGDVMIQNTGLTSLDGISLKQVGMFQIQNNRDLMKININNLMNASDLINFSGNYDQLMIDLPNLGTGTNMTFRNISSISLPSLEKLTGQLGFWGTEFKTFSAPNLTTVGDVVFMDNSKLTNITMPVLTTVSGGFNIARNDKLSSINLPKLNRVTGAIDFSGKFNTVDLNGLNDVEGGFSLQSTDGNFSCNHFDNLRKNVSKGKYKCDAKTNKPTTSNGNSGTASSSGSSSSGSSSATSSGAAVANGASVAVTGVAAFFYAVAQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BU22</accession>
    <name>A0A9X0BU22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789508.1">
        <property type="nucleotide sequence ID" value="XM_056934314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BU22"/>
    <dbReference type="GeneID" id="81624563"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5484724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="75" mass="8074" checksum="334F890FBEF794B9" modified="2023-11-08" version="1">MPMETHDRDDSGAAIGVGGRSVRLWGSPTGEERTGMDRQGNLDDSTPASDHLSLCSSVKFGVSALVWRSKLRVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUA1</accession>
    <name>A0A9X0BUA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_004921</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789717.1">
        <property type="nucleotide sequence ID" value="XM_056934523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUA1"/>
    <dbReference type="GeneID" id="81624772"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="672"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="677"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5484933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="791" mass="89307" checksum="37E6230455420B92" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXQ9</accession>
    <name>A0A9X0BXQ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003634</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790777.1">
        <property type="nucleotide sequence ID" value="XM_056933236.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81623485"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF38">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="71"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5488744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="135" mass="15060" checksum="B5C912E35235ECBB" modified="2023-11-08" version="1">MPQPAPTSFHDSPPMTTDGWSYCVPQPTSLGSRSDRGSNDSCSPPLSLGASPSSPPTSQNSHSDETTPRVDRSRIEKRRLNTLAARRSRQRRVDRMKDLEDELAAMRRERDELKLKVSRLEGETEALKGLLSRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXW5</accession>
    <name>A0A9X0BXW5_9EURO</name>
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        <recommendedName>
            <fullName evidence="8">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_003648</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790791.1">
        <property type="nucleotide sequence ID" value="XM_056933250.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81623499"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
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    </dbReference>
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        <property type="entry name" value="Ank_2"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="536"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="569"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="688"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1458"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="595"/>
            <end position="657"/>
        </location>
    </feature>
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        <location>
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            <end position="1053"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="1337"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
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            <begin position="973"/>
            <end position="1003"/>
        </location>
    </feature>
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            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="639"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1038"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5488758.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1776" mass="200173" checksum="AD840020F7D78539" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYC8</accession>
    <name>A0A9X0BYC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791105.1">
        <property type="nucleotide sequence ID" value="XM_056933564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYC8"/>
    <dbReference type="GeneID" id="81623813"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="93" mass="10109" checksum="D5C19776ABC5B756" modified="2023-11-08" version="1">MGRKDGSKVSAEAMATTDGDVHAIDGDKSLRGSESVQSLRTLRARVVSRRRKQKSVFSGSKSLLAVENGVRHVRSGEDEVTDPLRSGRVQVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYF8</accession>
    <name>A0A9X0BYF8_9EURO</name>
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        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_002273</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791835.1">
        <property type="nucleotide sequence ID" value="XM_056931876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYF8"/>
    <dbReference type="GeneID" id="81622125"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5490706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="285" mass="31670" checksum="C96D0B08E23C4613" modified="2023-11-08" version="1">MAGADFDQTKAYATQEEGTGYFDDGREIELLHFVYAHPDLDNIRGSPAKVLAAIDEFGRTKKYLMNVGEDKGRIVCDLIKETKPKTMVELGGYVGYSCILFGDMLAKVGGQRYFSLEMNPEFAAVIMSLVHLAGLSHVVEVVVGPSDASLARLHAEGQLKVIDLLFLDHYKPAYTTDLKLCEELKLVRPGSVLAADNVIKPGNPAYLEYVRSTVQQRRAKLGELHRGEELPEETVDQYKKRYAMSFNKSPGNPNLVYESRIVHSWEPTGVPDGVEITRCVGEDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYR2</accession>
    <name>A0A9X0BYR2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mitochondrial processing peptidase</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Beta-MPP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_002513</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Preferentially, cleaves after an arginine at position P2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.</text>
            <dbReference type="EC" id="3.4.24.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792075.1">
        <property type="nucleotide sequence ID" value="XM_056932116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYR2"/>
    <dbReference type="GeneID" id="81622365"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000002">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="16">
        <location>
            <begin position="51"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="17">
        <location>
            <begin position="203"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5490946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="479" mass="53162" checksum="1D806D152DE2B0AB" modified="2023-11-08" version="1">MASRRLALNLNQALRSRAALKSIQPVKRGFASPVALPSTTQSTTLSNGFTIATDYSPWAQTSTVGVWIDAGSRSETDRTNGTAHFLEHLAFKGTNKRSQHQLELEIENMGAHLNAYTSRENTVYYAKAFNNDVPKAVDILSDILQNSKLEPAAIERERDVILREQEEVDKQLEEVVFDHLHATAYQGQPLGRTILGPKENIQTITRENLTDYIKTNYTADRMVLVGAGGIPHEQLVRLAEEHFGGLPNKPPTSAALAIAAEQKRTPEFIGSEVRLRDDTIPSAHIALAVEGVSWKDDDYFTALVAQAIVGNWDRAMGQSPFLGSKLSSHVSHNHLANSFMSFSTSYSDTGLWGIYLVSENLTNLDDLIHFTLREWSRLCRSVSNSEVERAKAQLKASILLSLDGTTAVAEDIGRQIVTTGRRLSPEDIERVIGSITEKHVMDFANRKLWDQDIAMSAVGSIEGILDYQRIRNDMSRNMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZD7</accession>
    <name>A0A9X0BZD7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="8">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_002981</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="8"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792543.1">
        <property type="nucleotide sequence ID" value="XM_056932584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZD7"/>
    <dbReference type="GeneID" id="81622833"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000009">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="96"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5491414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="412" mass="44712" checksum="A972566EB71AE05B" modified="2023-11-08" version="1">MEGTGHDSDVIQSPELEVKRLCACAAAHVTTHRLKSRTPALVPLELFHGSNPGSTHHHQQGSAILARGDESSVQSTIMALVSGPGRAAGTLSDQELHIAKHVAYIKNLDTRKDELEYWLTEHLRLNGVYWGLTALHLLGHPEALPRDQTIDFVLSCQNDNGGFGAAPGHDAHMLYTVSAVQILVTVDAVDELDRRGLGGKQKVGSFIASLQNKEDGSFMGDQWGETDTRFLYGALNALSLLNLLDLVDIPKAVSYVQSCENLDGAYGVTPGAESHSGQVFTCVGALVIAGRTDLINQDRLGAWLSERQTDNGGFNGRPEKLPDACYAWWVGSSLAMINRLHWIDGKKLASFVLQCQDPEAGGFADRPGNMVDVYHTLFGIAGLSLLGYEGLQEIDPIYCMPKSVVERCLSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZE7</accession>
    <name>A0A9X0BZE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tropomyosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_003011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792573.1">
        <property type="nucleotide sequence ID" value="XM_056932614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZE7"/>
    <dbReference type="GeneID" id="81622863"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000114">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5491444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="161" mass="18959" checksum="E9EDD43AEFA791ED" modified="2023-11-08" version="1">MEKIKERMSALRLEADEAHEQVEELKKKVKTLEQENLSKEQEITSLNHRNQLLEEEVEKLESSVKDAKDAANQSAQHDTQNEALQRRVQLLEEEAEENDRTLRETNEKLRQTDVKAGHYERKVQALETERDQWEAKYEEMAKKHAELQKDLHDLEVSISNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZH8</accession>
    <name>A0A9X0BZH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_001308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792942.1">
        <property type="nucleotide sequence ID" value="XM_056930911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZH8"/>
    <dbReference type="GeneID" id="81621160"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5492562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="258" mass="28632" checksum="7F8D8A177461CDA4" modified="2023-11-08" version="1">MLTLLIFHETFFVGKQDVAHCQNYELPIWLAAAFDLPEFINILSSSGADINESDRNGQTPLHISVKFGNAASISRLLVYECLYFNTQDREGRSALHVAAEAGLSTIMRTLLARPGIDVNLRDNTGATALFRVIVKGSIPPIVLLLAEEEVDINSAGPEERTVLINTVQQRSYSIVCLLLDRKDLDVDVQDAGGLTALCWATCLGDVDMNEATYKYFNNLYPKRRLIWINISAASPRFSRLLGMVTFLVQLVSYSKATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZV9</accession>
    <name>A0A9X0BZV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trafficking protein particle complex subunit 6B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792720.1">
        <property type="nucleotide sequence ID" value="XM_056932761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZV9"/>
    <dbReference type="GeneID" id="81623010"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000020">
        <property type="entry name" value="Trafficking protein particle complex subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="187" mass="21022" checksum="554A2C35EDE9335E" modified="2023-11-08" version="1">MSFDASASLSVSDPNARALSSSCFDFLLIELVPMAERLAKDLASQENPEDPEVRESTYFRLESLGYRVGQGLAERFSRDRPRFTDNLDVIKFLCKDLWMVLFRKQIDNLKTNHRGVYVLTDTAFRPFARMSMAVRSDAVNMAQAYLWFPCGVIRGALANLGINTTVQAETSELPGATFQIKTVQARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZW1</accession>
    <name>A0A9X0BZW1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="1" key="1">
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            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5491713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056932882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZW1"/>
    <dbReference type="GeneID" id="81623131"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5491713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="102" mass="11541" checksum="F6ED2AB076364C6E" modified="2023-11-08" version="1">MGGLEGPGLVNSWFSVKIKAQFKDLKEVLLLDFDLDCTCRASPLHSTSSFSWWWFNIISGDEQLELSQGSPMMRKCAVAFWDWVPLLDGRGSPVLQSQKYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
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        </recommendedName>
    </protein>
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        <name type="scientific">Penicillium diatomitis</name>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="1"/>
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            <begin position="1"/>
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    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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</entry>
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            <strain evidence="1">IBT 30728</strain>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">IBT 30728</strain>
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    </reference>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="81621880"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34673">
        <property type="entry name" value="COLD-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34673:SF1">
        <property type="entry name" value="COLD-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5493282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="74" mass="8171" checksum="8C067C3A02A6E5F7" modified="2023-11-08" version="1">MCDAPFFFPICIQCGTDQNPCRCKVVGPTLGHLLAGIDLLWLRMYTNGQRVSRAEDVLGYPVKLNGQVSNAIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0Q1</accession>
    <name>A0A9X0C0Q1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanine nucleotide exchange factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_001970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
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    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_056931573.1"/>
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    <dbReference type="GeneID" id="81621822"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="REM"/>
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        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
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        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
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    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="389"/>
            <end position="517"/>
        </location>
    </feature>
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        <location>
            <begin position="1416"/>
            <end position="1659"/>
        </location>
    </feature>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1321"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="568"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="649"/>
            <end position="662"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="868"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="966"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1231"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1287"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1322"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1337"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1354"/>
            <end position="1363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5493224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1662" mass="182730" checksum="4B1139D3DA930E80" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0R5</accession>
    <name>A0A9X0C0R5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="19">ETF-QO</shortName>
            <ecNumber evidence="19">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">N7539_002015</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 19">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="19">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ETF-QO/FixC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="19"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793649.1">
        <property type="nucleotide sequence ID" value="XM_056931618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0R5"/>
    <dbReference type="GeneID" id="81621867"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000015">
        <property type="entry name" value="Electron transfer flavoprotein-ubiquinone oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 19" id="KW-0408">Iron</keyword>
    <keyword evidence="14 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 19" id="KW-0813">Transport</keyword>
    <keyword evidence="15 19" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="21">
        <location>
            <begin position="571"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ5493269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="611" mass="68166" checksum="6F3FB5CCC35121AF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C250</accession>
    <name>A0A9X0C250_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor CWC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_000232</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CWC24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794129.1">
        <property type="nucleotide sequence ID" value="XM_056929836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C250"/>
    <dbReference type="GeneID" id="81620085"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000045">
        <property type="entry name" value="RING finger protein 113A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 7 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="249"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="308"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5495116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="337" mass="36868" checksum="06624091C06B32DE" modified="2023-11-08" version="1">MTDDTAAPEAVPQFGFKKRARGKASFRKKPTTPPPASDSGSDFTSSDDEDGQRIKRRRKNVAVTASSAANATRGDPAGDQPTSTGPAPLSTNNDATKSSNWYDEDLSAKNLLGSTRAQASTTTGPDGTYKGSANYSNFIQKNPDAPTKQFGPMKAPTNVRTVTVMDFAPDVCKDWKQTGWCGFGDSCKFLHAREDYKQGWELDRDWEIGTNGKKLSGRVVSQRKGARKTAEDDEDEDDDELLDSIPFACIICRKPYQNPIITKCGHYFCESCALQRYRKNPSCAACGAGTGGVFNTAKKLNTLLEKKREKARKEREQAIENGEEVSEEEGDDGEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2E9</accession>
    <name>A0A9X0C2E9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_000648</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794545.1">
        <property type="nucleotide sequence ID" value="XM_056930252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2E9"/>
    <dbReference type="GeneID" id="81620501"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="11">
        <location>
            <begin position="160"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="380"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5495532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="424" mass="47898" checksum="D604B65A63281841" modified="2023-11-08" version="1">MAGAFSEWRKLPISLSELCINTTLRCGQSFRWQHIPEDGEWRCVLHGKLLSLKQDSSHLYYRHYRASPAKLLPSPPYSQVQSRAQSDTDQGSDVKVPAGHANDDDVLRLLKHYLNLAPSLSILYDQWSSKDANFKKKAVQFTGIRILRQDPWEALVSFICSSNNNIARISQMVEKLCLNYGEFVAKIDDRAYHDFPNAEALAGSDVESNLRSLGFGYRAKYIQRTAFMVSQEREKGWLEGLCNPESPVFGFQPTPGDEMQTQGRQGYRNAHENLLELQGVGPKVADCRDYRFGKSSQKSLTKATYDAVANHFRKIWGQEAGWAHSVLFTADLRSFSDRLAVTKHVDVSVKEEGSEIQVKNEVTTAVTLMAPKEELGDVNIKSEEVETKPHIEVARGKKRKGADAEITKAAQTTETRRMSKRLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2K0</accession>
    <name>A0A9X0C2K0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peroxiredoxin PRX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_000798</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794695.1">
        <property type="nucleotide sequence ID" value="XM_056930402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2K0"/>
    <dbReference type="GeneID" id="81620651"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009668">
        <property type="entry name" value="PRK13189.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF9">
        <property type="entry name" value="PEROXIREDOXIN PRX1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="51"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5495682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="262" mass="29407" checksum="1DAE575666F1943D" modified="2023-11-08" version="1">MVLRIAHQMAFQSLRAVPKVVAQAPLRVQLRQPQVAFRRCFASVPQEQPRLRLGSTAPNFKALTTNGEIDFHEFIGNSWTILFSHPADFTPVCTTELGAFAKMKHEFDKRGVKMIGLSANDIGSHGEWIKDINEVASTTVQFPIIADADRKVAFLYDMIDQQDLDNIDQKGIAFTIRSVFVIDPNKKIRLTMMYPASTGRNSAEVLRVIDSLQTGDKKGVTTPIDWQVGDDVIVPPSVSTEDAKKKFGEVREVKPYLRYTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2P9</accession>
    <name>A0A9X0C2P9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PDZ GRASP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_000817</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794714.1">
        <property type="nucleotide sequence ID" value="XM_056930421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2P9"/>
    <dbReference type="GeneID" id="81620670"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000026">
        <property type="entry name" value="Golgi reassembly stacking protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007583">
        <property type="entry name" value="GRASP55_65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893">
        <property type="entry name" value="GOLGI REASSEMBLY STACKING PROTEIN GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893:SF0">
        <property type="entry name" value="GRASP65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51865">
        <property type="entry name" value="PDZ_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ GRASP-type" evidence="6">
        <location>
            <begin position="145"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5495701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="391" mass="42142" checksum="0B1E24226E3E3306" modified="2023-11-08" version="1">MFGALNRFIGRLDGEPVPQPRTGPSDNAYGFQVLRNKDTELPLEPWFDFIIGINGHPIEDPDPNLFATEVRNCAGSSLTLEIWSAKVREAWKLRRDHARVFTRFLIVKIVMRQGQRTHTVTVPVSATTPSLGLSLQLAPLSSTQHIWHILGVPSPLSPAYRAGLLPHSDYIIGTPSGTLRGESALGELVEDHLDRTLVLWVYNSEFDVVREVELVPTRGWGGEGALGAELGYGALHRLPVGLGEEVEGPGEVVFETKDNVPSGPLSDYNNAPATYEPSGGNYLVPANLVSPPPLVPQGRGTSPQTAVSPASRRNGKARHGVSPNRAFDDYFAEGEQKSRAQDFTPSRKGTPLPPPPKVGAPPQASSSPAPTASEAMRNAESEGEPGPAQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WK89</accession>
    <name>A0A9W9WK89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dephospho-CoA kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_009549</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785639.1">
        <property type="nucleotide sequence ID" value="XM_056939144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WK89"/>
    <dbReference type="GeneID" id="81629394"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001227">
        <property type="entry name" value="Dephospho-CoA kinase CAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5466593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="29983" checksum="BF49DB0249EFCED1" modified="2023-11-08" version="1">MLIIGLTGSIATGKSTVSSILSSPPYSLPIIDADILARKVVEPGTVGYKAIVDYFHSTTPDLLLDDTSNPSPHGKPLNRPALGRRVFGDSEERKRDRQVLNRIVHPAVRWEVYKSLIFHYLRGQWAVVLDVPLLFESGMDLICGTVIVVGVHDPAIQMSRLRARDAHLTAEDAENRVRSQGDVSTKAAQAEFRGTSTARGVVVWNDADRTELEAAVKQAMSHIEGSSPRWWAWTLLLAPPLGVGVAAWNLMVNFATQKGWEKKRREEKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTS8</accession>
    <name>A0A9W9WTS8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787149.1">
        <property type="nucleotide sequence ID" value="XM_056938057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTS8"/>
    <dbReference type="GeneID" id="81628307"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="284" mass="31402" checksum="9D38BA01047A48EC" modified="2023-11-08" version="1">MEVVRARLFSHTKWATLRVQLRNLRDLVKIRPFSRDLVRTTPITLLLTPPSPSPARSTTGMSSPLRPGVRVWAGEPPSRRGGREMRIPGRVANWRVRPSRRKGYDENPKTTNVRAWQTPSPRPGISMRPVVLSLRPQDMRPLGRPPAAVGTQRLPTGEFDCPSPPRRLRGLGVAQRPRVGRDPLGLAAHPLIAHPEASRGPDGLRLMPVPSPPPRRPPTHPTPPAPSTGRLPGHLSLTHPRRAGRDRRPRGLQHRYDWLGGPPADVRLGIRWGTPGGNASPESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTW5</accession>
    <name>A0A9W9WTW5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_007733</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787199.1">
        <property type="nucleotide sequence ID" value="XM_056937334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTW5"/>
    <dbReference type="GeneID" id="81627583"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000001">
        <property type="entry name" value="Ribosomal protein L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_eL37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_eL37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003214">
        <property type="entry name" value="PRK04179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="52"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5475446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="92" mass="10423" checksum="9556D5BAC03B2BF6" modified="2023-11-08" version="1">MTKGTSSFGKRHNKTHTLCRRCGKRSYHIQKSTCANCGYPAAKTRKFNWSEKAMRRKTTGSGRMRSLRDVHRRFTNGFQTGTPKGARGPQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTX6</accession>
    <name>A0A9W9WTX6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_007748</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787214.1">
        <property type="nucleotide sequence ID" value="XM_056937349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTX6"/>
    <dbReference type="GeneID" id="81627598"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22749">
        <property type="entry name" value="Otubain_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF15">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUBAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5475461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="493" mass="55062" checksum="2943432888C34452" modified="2023-11-08" version="1">MSSLFHQSWSYLDPHQPYSEKQKFPGCYQDVLAPPAFFRSLGLPNLAALEPVSFIMSNSSNMNALSADEMERFQKLSNDFEPEAPGLLVSPKQSSQSIAMEYANADPTFATKTNALAITHPMTRVMKRDGNCGWRAMAFGYFETLFSFRDLLRVEQERMRIKSLNYTLDQVGYPEHLYEMFTDATDEVFAQISTAIQNSDPDESFLVNAFNDEYNSNSIVMHFRLLTGAWMKVNRAQYEPFLEPIPLDQYCATEIDTVRSEIDQVGLQALTDGVISNAGFGVEVLYLDRSQGDAVTPHQFTQNCPSDATIRLLYRPGHYDIIYRAEQTVNVAPVVNFQYAMTSDYVSWDQGALSFDANPHLMAIPNLMADPAFAMGGAPMSPVSSVSPSPASPYRLSPTQEMYPSPMQSHAIIPAIPVSSPTPSLPSAAPPPMTSLPSRSNDGPQIRLNPLVMRPSLNHLPVTAPFKNSPYNQAHFRNQDFEPIHWAPNESRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTY5</accession>
    <name>A0A9W9WTY5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787217.1">
        <property type="nucleotide sequence ID" value="XM_056937352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTY5"/>
    <dbReference type="GeneID" id="81627601"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF7">
        <property type="entry name" value="DJ-1_PFPI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040721568" description="DJ-1/PfpI domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="DJ-1/PfpI" evidence="2">
        <location>
            <begin position="56"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5475464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="224" mass="24425" checksum="61DB58A5EF3685AB" modified="2023-11-08" version="1">MTTSQVAPQPLRIGVLLVNCVQLLDLAALDLLFMTSPEWLADINMPQEILDMGRPCKIYYITREGPNTHAPVTCQLSIQVTHSLEDAAVAPGALDILFVPGPPPRVMPPAEEYLEYTRQHNSAGTTIMTVCTGALVAAHAGITKGRVATAPRFLIENVKKAFPEAKVWDETLRVTRDGNLWMSGGVTNGHDLVAEYIRMHYPEPVVNVVLGTADVAPRALKYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTY6</accession>
    <name>A0A9W9WTY6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_007774</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787240.1">
        <property type="nucleotide sequence ID" value="XM_056937375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTY6"/>
    <dbReference type="GeneID" id="81627624"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000131">
        <property type="entry name" value="Glycoside hydrolase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000106">
        <property type="entry name" value="Glycosyl hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="65"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="6">
        <location>
            <begin position="630"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="578"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5475487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="751" mass="85415" checksum="39E11E67AE160BCA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU95</accession>
    <name>A0A9W9WU95_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial inner membrane protease subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_007907</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787373.1">
        <property type="nucleotide sequence ID" value="XM_056937508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WU95"/>
    <dbReference type="GeneID" id="81627757"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S26" evidence="13">
        <location>
            <begin position="94"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5475620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="294" mass="33504" checksum="1AB59C98E946C661" modified="2023-11-08" version="1">MPPPDRMVGKLSKLRAINPTDAKLLARNGKPLPKRSANAAPPPQPEPQPEPAFSSEHYGPSLGRRRLFEPLRNTFARFRQRCRKLPTPILLSARTVQVMIPIVPIGYFLTDNVMRITKVNGPSMTPYLNENYDQMHTQSDTALIQMWSKHRWIPWKDGRRLERGMVVIFPSPADPSRKAVKRIVGLPGDRVTNRDFPNEGAHLVPWNHVWVEGDAANQQRSMDSNSYGPISISMIEGLAIAVLSPRMRWLNWKDWESKDVDAAGSNGRLRPDYRKSIQDRIVKNAAKVERPPEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUL9</accession>
    <name>A0A9W9WUL9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787577.1">
        <property type="nucleotide sequence ID" value="XM_056936778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUL9"/>
    <dbReference type="GeneID" id="81627027"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="173" mass="18688" checksum="3A3D84185DAA8B58" modified="2023-11-08" version="1">MTLDYPRTLIYDRPPDQDKSTEESHVNGHCSQYRRAKSRSFSVLYSRSATSIVKLLSQVPDFMPTVEHRWGPCAGLADPVAASSIYALVVPGAGPRATFYDYLEDVDDIFLDGLLDGLLDGLLDGLLDGLLDGLLDGLLDGLLDGLLDGLLDGLLDDIGSFGVTRGHFTQLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUS6</accession>
    <name>A0A9W9WUS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SDS23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein sds23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_007232</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in DNA replication and cell separation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SDS23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787632.1">
        <property type="nucleotide sequence ID" value="XM_056936833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUS6"/>
    <dbReference type="GeneID" id="81627082"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030071">
        <property type="term" value="P:regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02205">
        <property type="entry name" value="CBS_pair_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016711">
        <property type="entry name" value="Ssd23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF36">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018148">
        <property type="entry name" value="UCP018148_CBS_YBR214w"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="209"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="285"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="422"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="514"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="422"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR018148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5477088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="554" mass="59145" checksum="38D03A440D3061FC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUU4</accession>
    <name>A0A9W9WUU4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein kinase SCH9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787675.1">
        <property type="nucleotide sequence ID" value="XM_056936876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUU4"/>
    <dbReference type="GeneID" id="81627125"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="74" mass="8619" checksum="C36FCF0E225FB504" modified="2023-11-08" version="1">MQANFKGFTFVNESSIDHHLKHDPADRMDEDPLNEETWQRTHRATHSNDQRMSGVQRTDGPETGIFNVDDNFDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV65</accession>
    <name>A0A9W9WV65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HCNGP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787796.1">
        <property type="nucleotide sequence ID" value="XM_056936997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV65"/>
    <dbReference type="GeneID" id="81627246"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012479">
        <property type="entry name" value="SAP30BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464:SF0">
        <property type="entry name" value="SAP30-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR PROTEIN HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07818">
        <property type="entry name" value="HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21201" checksum="6AF1363460A99F53" modified="2023-11-08" version="1">MLGLGAYESSSEDEDRVRSSPERSSAPPNGPVLGPESGPVPMNDTQSPGGRSASGRSSPFSSTRALVHDLTLPPVPNLNIPPSPPGSPNAALNAKFEHFLALKKQGVHFNAKLACSSSLRNPSLLKKMMEHAGIKEHEQYNTSLPSDIWDVSNLPQWAFKDELLKTQQEVRQSREEKNATGQRSSIDFVSTAATNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVC0</accession>
    <name>A0A9W9WVC0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_007530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787930.1">
        <property type="nucleotide sequence ID" value="XM_056937131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVC0"/>
    <dbReference type="GeneID" id="81627380"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018277">
        <property type="entry name" value="Ribosomal_eS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00628">
        <property type="entry name" value="RIBOSOMAL_S19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="118"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5477386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="16473" checksum="9961F262802F52BB" modified="2023-11-08" version="1">MGGVSVRDVDAQKFIAAYSAFLKRQGKLPIPGWVDTVKTSASNELPPQDADWFYVRAAAVARHIYMRKTVGVGRLRKVHGSTKNRGARPAHHMDASGSVDRKALQALEKIGVLEVDEEKGGRRITQSGQRDLDRIAKTTVDEDEESDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVD9</accession>
    <name>A0A9W9WVD9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_007560</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787960.1">
        <property type="nucleotide sequence ID" value="XM_056937161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVD9"/>
    <dbReference type="GeneID" id="81627410"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000018">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase prp16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000313">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="198"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="383"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="876"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="835"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="892"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="915"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5477416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="924" mass="103189" checksum="1502277A0CFC0186" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVF8</accession>
    <name>A0A9W9WVF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSBA-like thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787545.1">
        <property type="nucleotide sequence ID" value="XM_056936746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVF8"/>
    <dbReference type="GeneID" id="81626995"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="137"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="237" mass="25769" checksum="65E8E6C4463CF227" modified="2023-11-08" version="1">MTNFNIQIISDTICPWCYVGYRRLSRAILAHQGQHPTDTFTLDWHAFYLNPSSPEYPGVNKAQAYGLKFGHERTAAIFARLAAVGEGEGIKFNFGGNTGKTRDSHRLLWYAGQLEHAKRGTGTGTGTEGATAVIGGVQSRVAEKLFRAYFEDEKNITDPAVLLEAGVEAGLDEGAVKKLLGSDEGGAQVDAEAKMASMRLVTGVPYFTIQGKYAVEGADAPETFLEVFERVKEDEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1Z6</accession>
    <name>A0A9W9X1Z6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arsenate resistance ArsH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_006820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788356.1">
        <property type="nucleotide sequence ID" value="XM_056936421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1Z6"/>
    <dbReference type="GeneID" id="81626670"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000027">
        <property type="entry name" value="Arsenical resistance protein ArsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014063">
        <property type="entry name" value="Arsenate-R_ArsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02690">
        <property type="entry name" value="resist_ArsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43590">
        <property type="entry name" value="ARSENIC RESISTANCE PROTEIN ARSH (AFU_ORTHOLOGUE AFUA_5G15030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43590:SF1">
        <property type="entry name" value="ARSENIC RESISTANCE PROTEIN ARSH (AFU_ORTHOLOGUE AFUA_5G15030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="8">
        <location>
            <begin position="93"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5480926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="305" mass="34793" checksum="2A0D0DEF1698850D" modified="2023-11-08" version="1">MVVDSHAVLQSQAHTTSTASPLNHHALFDNSESSQNLQSLAMPLDEDTKEIRDKYRPFILDTPSANDWVENLELDTALQMAQNNLRLTNQRLKVLVLYGSLRSRSYSRLVALEASRILFRLGCDVRVYDPEGLPMKNDRDHGHAKVQELRQLSLWSDGHLWVSPEQHGNLTAVFKNQIDWIPLTTGSVRPTQGRTLAIAQVCGGSQSFNAVNSLRILGRWMRMFTIPNQSSIPQAYTHFPDEGQPDDQRLKPSGNRDRLADCMEEFVKYTILMRPHLELFGDRYSERNERRVKAEKEKAKLEAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2C0</accession>
    <name>A0A9W9X2C0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788385.1">
        <property type="nucleotide sequence ID" value="XM_056936450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2C0"/>
    <dbReference type="GeneID" id="81626699"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="93"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5480955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="593" mass="66509" checksum="9C04FC0E069A6C6E" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2I0</accession>
    <name>A0A9W9X2I0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Up-regulated during septation protein 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_006152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_056935754.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81626003"/>
    <dbReference type="Proteomes" id="UP001148312">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:myosin filament"/>
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        <property type="term" value="C:myosin II complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:microfilament motor activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="3">
        <location>
            <begin position="73"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7801" evidence="4">
        <location>
            <begin position="616"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="821"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="421"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="498"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="676"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5482706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="840" mass="95084" checksum="441B713C6B8585F3" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2M6</accession>
    <name>A0A9W9X2M6_9EURO</name>
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        </alternativeName>
    </protein>
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    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Petersen C."/>
            </authorList>
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        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen J.L."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
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            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
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            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
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    </dbReference>
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        <property type="entry name" value="PROK_CO2_ANHYDRASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5482732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="284" mass="30772" checksum="60DEB96A2226F9A7" modified="2023-11-08" version="1">MNPGGLAMQFRCFARASQAVHPIAGLPRLAPVRHSLNTTFSRVSSFSTSAPAYCANSQSPPSASETNNKSSLDSTDKYVAGLRHNKNWAAQTAREHPDLFPTLANGQQPQILWLGCSDSRCAETSMLGLLPGDVFVHRNIANILHPGDLSSGAVIEFAVKHLKVKHVVVCGHTSCGGVAAAMGSKQLGILDPWLLPLRQVRERNLATLESLPVDQAAEKLVELNVRESLNIVTQKSVVLEAIQERGLQVHGLIYDVASGVLRELDTTDSDEVIKKRLVAFKLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2U0</accession>
    <name>A0A9W9X2U0_9EURO</name>
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        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_006941</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein-folding chaperone binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
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        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="76"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5481047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="336" mass="38341" checksum="A3A573A7509D3C40" modified="2023-11-08" version="1">MASILPFIGWAILPNYATSFLQSVYYGITIRAGDPRPMPQTPRFDRDRRRIFIFVIISYLLYTLYETFHQVQVAGDYYQLLGVSPFADERTIKSRFRKVAAQFHPDKETLADPVKRFAYDRFGPDMMSWGDLKTMREYVTTSLSKAVLPQYIGGFATMVVLNWLWWANWGRYWRFYTFAAMLTLELGLITHPQAVFMPTKYLPAVLRAWIPGEKSFYLLPFQILTLARRASITLHIFISQMAPPNAPASKGDALSPQTMQRLGQLVHLSQGTDFEATRLMQLGLAPFRGDRESVTALRRGMKEGLIMGGVRASPEVQRAVAQVMERRKAASGDMVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2U9</accession>
    <name>A0A9W9X2U9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_006295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788821.1">
        <property type="nucleotide sequence ID" value="XM_056935897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2U9"/>
    <dbReference type="GeneID" id="81626146"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08278">
        <property type="entry name" value="benzyl_alcohol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350:SF20">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="15"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5482849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="386" mass="40126" checksum="F8A513985732246F" modified="2023-11-08" version="1">MGSDGQIATKAFVVRSPGSPFLLEDVILDEVRANEVLVEIKYTGLCHTDIVVQSGGIPVGDFPAVLGHEGMGIVRRLGSRVNTNSLNEGDEVLLSFSTCCECGPCKSGSLGSCIRFTEINIAGARGPSISDSPISFPNGDPIRGQFFGQSCMAKLAIVPETSIVKLNRGSALSESDIASLAPLGCGYLTGAGTVMNVLKPIPTSRFVILGMGAVGLSALMAAKAIGVESILAVDLFDSKLELAKSLGASCTLNTKDLPDLVQGICSLFPEGVDHILDTTGVGTVLESAIRALGHGGILAIVGAPPVTASVNISPLDLLMNCKRVVGAVEGAADPAVLLPLLVDWYEEGKFPVNRLAKVYPADQLHVALEDLHAGKVIKPVLDWSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2W4</accession>
    <name>A0A9W9X2W4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-ketosteroid reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_006159</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788685.1">
        <property type="nucleotide sequence ID" value="XM_056935761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2W4"/>
    <dbReference type="GeneID" id="81626010"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051593">
        <property type="entry name" value="Ergosterol_Biosynth_ERG27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647:SF1">
        <property type="entry name" value="3-KETO-STEROID REDUCTASE ERG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647">
        <property type="entry name" value="DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5482713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="49546" checksum="4AFAA56BDFF8739C" modified="2023-11-08" version="1">MDESKSPRESQDLYILVTGANSGLGFSICCRLADEFLSSHHYDDTLTIIFTTRSARKAEDTRRRLEKHLHSSAKSTPSDRARVNFVSESVDLGDLPSTRALSRRLCQHYPKLDAVILNAGIGGWSGINWFEAIWGICTDLVHQVTWPSYKLAPVGVLTSRQTQREEEPALGAVFCANVFGHYMLAHNVAPLLKKAKSPNGPGRVIWVSSIEATIKAFDINDIQGLQTKVPYESSKALTDILALTSDLPSTAPWSVEGFFGTPSKEDRGPDESSTEVTPEMHVCHPGICATSIIPLPLPLVWAMVASCWIARILGSPWHAISTYVAAWAPVFLALSSQGALEAAESPYRQSGGGRVKWGSSTNRLGAERVSSTEVEGWGYGGVVGRPVVESDRLRRRKRGAVDLTREEKENFEELGRACWKQMEQLRIKWEGILDQAEQRQSSSVDKPTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X329</accession>
    <name>A0A9W9X329_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent DNA helicase MER3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788944.1">
        <property type="nucleotide sequence ID" value="XM_056936020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X329"/>
    <dbReference type="GeneID" id="81626269"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052247">
        <property type="entry name" value="Meiotic_Crossover_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835:SF3">
        <property type="entry name" value="HELICASE FOR MEIOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835">
        <property type="entry name" value="HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5482972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="213" mass="24425" checksum="990CD5742E904FDA" modified="2023-11-08" version="1">MELAICRLLNSLTDERFKVVYQAPTKSLCSERFRDWSNKFARLGLKCAELTGDTDHTQLRSVQSSHIIITTPEKWDSITRKWKDHMRLMQLVKLFLIDEVHILKETRGATLEAVVSRMKNIGSNVRFVALSATVPNSEDIATWLGKDAANQHIPAHREHFGEDFRPVKLQKFVYGYHSTGNDFVLDKICGSKFVHHLREVFRGESLIVSVQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X336</accession>
    <name>A0A9W9X336_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_006302</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788828.1">
        <property type="nucleotide sequence ID" value="XM_056935904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X336"/>
    <dbReference type="GeneID" id="81626153"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07135">
        <property type="entry name" value="ALDH_F14-YMR110C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000025">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF11">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="15"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5482856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="513" mass="55954" checksum="72C18F41CB614ACE" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X390</accession>
    <name>A0A9W9X390_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788421.1">
        <property type="nucleotide sequence ID" value="XM_056936486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X390"/>
    <dbReference type="GeneID" id="81626735"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5480991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="381" mass="43272" checksum="3F88967C038C2072" modified="2023-11-08" version="1">MILHLYKQLATEEYRTETHLRVVYAVTAAIDLCTTGAVVMDEPLDESHSASVLPAWHVQHPKSSNADATFMMTTGNRILHDVVPDSHPCKKELLQLYAEFQQCCVNYECVLAARHQLSTEESIRRAMQLDMATVTSLTGSTFNVQRTAYYTTWLIRVAQLLTCYQQILSTRERRIFFFDLSASMLDVLGIVDDLRDGKCMNVEIPKDLPIDECSQYVTDDMFKEFIAGEPHNPFLWASLELGRGESTAMDLSSQQKAEILITVEECYCVSPEIAEDSAARRARLTRLCAMFLKYNIVQYVKQKTLREAIRKYLLIQQMGVKTGLSLPQDLLSYSLGSLVYQETHSRSDEIASKIQRIMDTSLVVMSEKEKIFGLFDALQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3A5</accession>
    <name>A0A9W9X3A5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_006301</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788827.1">
        <property type="nucleotide sequence ID" value="XM_056935903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X3A5"/>
    <dbReference type="GeneID" id="81626152"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="100"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5482855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="432" mass="47189" checksum="A9B11C230216C53C" modified="2023-11-08" version="1">MSGLKEIDDKKDFGHVQGTELDESASVDTITALVAEAVLLAGDQVCLAIMAQSWSLSVLGWVPGIITMLLSGALFWTTSITMHKFIMKYPQILATANNIILIAFHVLTGAKVLNILSDHSICTALFSGLVTIMGIVMSAPRTLRHVSFMSMFSSACMGIAILLFLVFAGMEKSPLYGYNGDFPSDGPVQTYAFPLPGTTWIACMNAVLNITFLWVPQILFPTFIAEMERPQDFPKALAVLAVISGVLFIVAPSHWIPLPRTIRNSTRLWQPGVVAYKKASFGFVIVPTLIIGVIYANVTAKFIYNQILGKSRHSHSNTFIGWTVWSLIMIGIWVIAFIFSEVVPSMGDFLSLLGAAFDSFFGFLFFAVAYWQLNRGRLFADPQRTILSLVNVFVTMVGLFMLGPGLYAAVEAIIADYAGSTTPAFTCANLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3L7</accession>
    <name>A0A9W9X3L7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7727 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788977.1">
        <property type="nucleotide sequence ID" value="XM_056936053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X3L7"/>
    <dbReference type="GeneID" id="81626302"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056144">
        <property type="entry name" value="DUF7727"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40629">
        <property type="entry name" value="PRO41 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40629:SF1">
        <property type="entry name" value="PRO41 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24853">
        <property type="entry name" value="DUF7727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7727" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5483005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="143" mass="16151" checksum="4399BFBB34164F46" modified="2023-11-08" version="1">MGRLIKNHWARLIILTAATYQVVSAVEGFIWPKVFWDFISKNLDAAVAPVPVLQTLNLLMGLVGIAWEWPLRLLAGSLLHRSIEIRLMVYPLSALLAVLLYQGTDPALYYLIGIGVYFWAYSEGEIVCPEPWTLPKRSRVLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5I4</accession>
    <name>A0A9W9X5I4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="3 13">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_005942</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 13"/>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789416.1">
        <property type="nucleotide sequence ID" value="XM_056935544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5I4"/>
    <dbReference type="GeneID" id="81625793"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5484146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="431" mass="47884" checksum="89F9C562D8281742" modified="2023-11-08" version="1">MEDTTNNPSAQLRQPKKRFVGRRTAEAQSQKDTTSQADVESTAVQTAARRRTPRTLNQVPPEILDDPEIQAAIELLPKNYSFEIPKTIHRVRSSGAKRVALQFPEGLLIFATTISDILTQFCPGIETLIMGDVTYGACCIDDYTARALGCDLLVHYAHSCLIPVDVTKIKTLYIFVDISIDTSHLIATLERNFKPGQTIATVGTIQFNATLHGLKPVLERAGFRVVVPQIMPLSKGEILGCTSPQLSDSEIDVLLYLGDGRFHLESAMIHNPSIPAYRYDPYSRTLTRESYDHDEMHTIRRGAIATAKTAKKWGIILGSLGRQGNPNTMAMIERHLAERGIPVVNLLLSEIFPGKLASMSDVECWVQIACPRLSIDWGYAFSRPLLTPYEALIALDVRESWDKANKGVYPMDFYAKEGLGRTKPEQAIRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X615</accession>
    <name>A0A9W9X615_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multiple myeloma tumor-associated protein 2-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789701.1">
        <property type="nucleotide sequence ID" value="XM_056934507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X615"/>
    <dbReference type="GeneID" id="81624756"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019315">
        <property type="entry name" value="MMTA2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039207">
        <property type="entry name" value="MMTAG2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580:SF0">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10159">
        <property type="entry name" value="MMtag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Multiple myeloma tumor-associated protein 2-like N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5484917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="243" mass="27071" checksum="63FB101073C3C495" modified="2023-11-08" version="1">MDLVAGVRKEGSRGGRGEFKWTDVQNSSHRENYLGHSLMAPVGRWQQNRDLSWYAKGDAEAEEERARQEREELERVKQAEQEAMARALGLPIPVKTEPNANLTPLGTNTNTLDRADATFAKARVVKGEEIEVKADIGTTSGVVENTHMIMRETVEEIVVEIVSIDVTDIDRGTERIDRDAHIRVHDHEVVMIGESGKDHIDTSAATHLLDSLAKQNDTETGLNLIADVRCSRGKELFCSRDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X657</accession>
    <name>A0A9W9X657_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tethering factor for nuclear proteasome STS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_004995</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Binds the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cut8/STS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789791.1">
        <property type="nucleotide sequence ID" value="XM_056934597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X657"/>
    <dbReference type="GeneID" id="81624846"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031144">
        <property type="term" value="P:proteasome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1590:FF:000001">
        <property type="entry name" value="Tethering factor for nuclear proteasome STS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1590">
        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013868">
        <property type="entry name" value="Cut8/Sts1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038422">
        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032:SF1">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08559">
        <property type="entry name" value="Cut8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5485007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="313" mass="34464" checksum="8D7C9561CA78CF40" modified="2023-11-08" version="1">MNSLVATPPVPPHFYENPRFSPSRIMSTPSSSYTSRKRKADDDSTDHDGRMSASPTNSPAFTPRQLPSVRNIKRSRPNVSGRPLALPRLLETLDTDALRTVVRTMCERHPQLADEVAQTSPRPSVSSTLHVLRNYQAVLQSSFPLGGNTESDYAYNRVRQPLTNLLEALSDFTPTFLPPNETQPSVSLSYLDGATEIIHALPRWSTPQNNIERDSAYDEICKAWILVIREAAKRGGGIQLQYGGWDQKLAKHNHNSDGKMQAAVNELGLSLGWMNGPDSPAHHGSGNNEMGSIRDQLLSGTYGLGTPVKVGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6L2</accession>
    <name>A0A9W9X6L2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BPL/LPL catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_005069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789865.1">
        <property type="nucleotide sequence ID" value="XM_056934671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6L2"/>
    <dbReference type="GeneID" id="81624920"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03144">
        <property type="entry name" value="GATase1_ScBLP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019197">
        <property type="entry name" value="Biotin-prot_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09825">
        <property type="entry name" value="BPL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="413"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5485081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="702" mass="76904" checksum="BB36FAB8B01CAFA8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6Y8</accession>
    <name>A0A9W9X6Y8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_005471</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790267.1">
        <property type="nucleotide sequence ID" value="XM_056935073.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81625322"/>
    <dbReference type="Proteomes" id="UP001148312">
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    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012966">
        <property type="entry name" value="AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052007">
        <property type="entry name" value="Bud4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
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    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08174">
        <property type="entry name" value="Anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00233">
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    </dbReference>
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        <property type="entry name" value="PH_DOMAIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1159"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="1"/>
            <end position="178"/>
        </location>
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            <end position="248"/>
        </location>
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            <end position="431"/>
        </location>
    </feature>
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            <end position="494"/>
        </location>
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            <end position="722"/>
        </location>
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            <end position="903"/>
        </location>
    </feature>
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            <begin position="1304"/>
            <end position="1385"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
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        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
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        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
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        <location>
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        </location>
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        <location>
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    </feature>
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        <location>
            <begin position="833"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5485483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1385" mass="153418" checksum="F2989E9937841E75" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X704</accession>
    <name>A0A9W9X704_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3 10">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_005440</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + H(+) = UMP + CO2</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the OMP decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3 10"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790236.1">
        <property type="nucleotide sequence ID" value="XM_056935042.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81625291"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000114">
        <property type="entry name" value="Decarboxylase,orotidine phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF9">
        <property type="entry name" value="URIDINE 5'-MONOPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="11">
        <location>
            <begin position="34"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5485452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="276" mass="29856" checksum="8EF981E3B838B0FB" modified="2023-11-08" version="1">MSSKSHLTYSARATTHANPLARRLFEVAEAKQSNVTVSADVTTTQELLDLADRLGPYIAVIKTHIDILSDFSEETITGLKSLAAKHNFLIFEDRKFIDIGNTVQKQYHQGTLRISEWSHIINCSVLPGEGIVEALAQTAQAPDFPYGSDRGLLILAEMTSKGSLATGAYTSASVDYARKYQSFVLGFVSTRALGEVESSVAPVKGEDFVVFTTGVNLSSKGDKLGQQYQTPQSAIGRGADFIIAGRGIYAAPDPVEAAKQYQQQGWEAYLARVGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XD19</accession>
    <name>A0A9W9XD19_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791099.1">
        <property type="nucleotide sequence ID" value="XM_056933558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XD19"/>
    <dbReference type="GeneID" id="81623807"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39475">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39475:SF1">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="127" mass="14050" checksum="BE787F7FAF168D51" modified="2023-11-08" version="1">MASYKPTHGAGMSSVGTNSLYEAGDQRNEPQSVINERERYTEGKENSHKNLDSKDERSIANKLASQGNKADPSHHHNNVTDREAELSKKDPTAPAKMHGNEPSKGAKIDAELQAEDEQRLREKGIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDI8</accession>
    <name>A0A9W9XDI8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791423.1">
        <property type="nucleotide sequence ID" value="XM_056933882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDI8"/>
    <dbReference type="GeneID" id="81624131"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001716">
        <property type="term" value="F:L-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF382">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="157"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="631" mass="69546" checksum="DC124C17119E26E9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE55</accession>
    <name>A0A9W9XE55_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791411.1">
        <property type="nucleotide sequence ID" value="XM_056933870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XE55"/>
    <dbReference type="GeneID" id="81624119"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="146" mass="16052" checksum="643174C0D2284945" modified="2023-11-08" version="1">MYGASTEALSYTWGRECCEDTFATLRRVGSNEVEKQRNDCQHELSIFPQVFSVSFSIFIQLPRCPSATCSTAVLLVEEIVHCHQAQPTQSRASKSMPSPSSLAVHTQQPQATHGILNKSQPRLGQAIIPVSWQLDSTNGASVNHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEI6</accession>
    <name>A0A9W9XEI6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_004463</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791606.1">
        <property type="nucleotide sequence ID" value="XM_056934065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEI6"/>
    <dbReference type="GeneID" id="81624314"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="186"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5489573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="340" mass="39168" checksum="9D9914801120FD15" modified="2023-11-08" version="1">MSRSVWIPRLIILAITFTSIACPSWWQPAVSKLYGSFYSWSLYNRSFFETLETVFCYVTIEPIYTWRYAHNPTRRVDIRQSTTNTKGRPALPKMKRPSTRLPELVTYVAPLLLLDLTLIKKYAGVDIASIRQSGGYAPCPASQGTISPSFLAPTFHRFTLHSPLQLVRALPPEAPTSRRVLFELAASIFLYDALFFVIHIAFHRIPFLHRIHGPHHGHNEIHPQVTNRLSVTERTALILLANFALNIIGSHVLTRTLFIPIFIYLLIEVHSGVELDWQYDKVLPPGWGAGPIKHAMHHREGKRYFQPFFCWWDNLLEEPESKEGKKWNRNAQKHAQPPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEJ1</accession>
    <name>A0A9W9XEJ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pdp3-interacting factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791929.1">
        <property type="nucleotide sequence ID" value="XM_056931970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEJ1"/>
    <dbReference type="GeneID" id="81622219"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF2">
        <property type="entry name" value="PHOSPHORIC MONOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5490800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="310" mass="35123" checksum="A8AAEB222331AB5F" modified="2023-11-08" version="1">MSPSMPTNSQKRKIIIFSDFDGTIFMQDTGHILFDSFGCGAEERNKLDEQIKTGERSFREVSEEMWGSLNVPFEDGFVVMEKSLEIDPGFREFHQYCIENGFPFNVISAGLKPVLRRVLDAFLGEKEAAAIDIVANDAIIDGSQWKPVWRHDNELGHDKALSVNEARARAQSECLPDEMPLIVFIGDGVSDLAAAREADVLFARRGLRLEEYCQEHKIPYTPFDTFADIKREIESISREDQRKTGGVGKPVRYNPRANLWRRISSKEAVPTLMATATPSKEEKMFLWPETFSELKPQATIQETEEPVTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEK7</accession>
    <name>A0A9W9XEK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_002294</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791856.1">
        <property type="nucleotide sequence ID" value="XM_056931897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEK7"/>
    <dbReference type="GeneID" id="81622146"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15760">
        <property type="entry name" value="FYVE_scVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164:SF30">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="173"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5490727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="292" mass="31997" checksum="35EC35C6BA321406" modified="2023-11-08" version="1">MTTTMAATAPNNSPFTAGGQAARGNDHMPSVTPISAHGQPSPTCSSTNTLANNSPTSPRLDKAALHQLPLQSRQLRPLKGPMYVPAALRPTERPQKSSPITPPRSVHGSLDSLNEDTEPISRRSTMESKSSGISKVAEHEWMKTEHLGEVTGMPTRDHWKADAASSSCDSPTCRSSFGIFTRRHHCRHCGHVFCYNHTPHMVPLDQNAAFHPEGVLSRACDLCWSAYKRWEETRTDRLNQIQNSIDAKRDPSPPTDDLESSQSSGRAALNPNLGQTAEVAASVPRDWNWSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XES7</accession>
    <name>A0A9W9XES7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_002492</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792054.1">
        <property type="nucleotide sequence ID" value="XM_056932095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XES7"/>
    <dbReference type="GeneID" id="81622344"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="567"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="150"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5490925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="681" mass="74106" checksum="7A775C05C7A2FEB2" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF16</accession>
    <name>A0A9W9XF16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DMAP1-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491055.1"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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            <end position="1684"/>
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    </feature>
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            <begin position="1867"/>
            <end position="1878"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5491055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1885" mass="208543" checksum="DA4083F654A2A461" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
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    <reference evidence="2" key="2">
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            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
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            <end position="277"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="6">BRCT domain-containing protein</fullName>
        </recommendedName>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
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            <end position="105"/>
        </location>
    </feature>
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            <end position="251"/>
        </location>
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        </location>
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            <end position="252"/>
        </location>
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            <end position="295"/>
        </location>
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        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5490818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="36499" checksum="7A590A73858CB8BC" modified="2023-11-08" version="1">MPAKVTESAKVSKPGTAFRRITVATTGDIYQGSQIPQWVKKNGGRFLEKVTTEVTHLITTEKAYLENISEVRAAKALGKIRIVSRDWLICSLYANPIRPVSEAPFLLENLTRPNNKDAEAKGAGGARNKVNPFDQKTTSGGSKRARTQAIQTILLDPSTGAAWDATLLRDGKTPRTREKIRLAIFESSASPKTYSTWARYSRVGKSQVDELTAPKSDITSAIKNFKDYFKSNTGKSWEERHSEDLPTPRQDDQGNVLPIHEGWYIYDNQENMFTRFLRQPPTSTSATGHASATSHEVSYTEHTDDSAADEEALSTLDAPLEENNAHDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFM6</accession>
    <name>A0A9W9XFM6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792443.1">
        <property type="nucleotide sequence ID" value="XM_056932484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFM6"/>
    <dbReference type="GeneID" id="81622733"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF67">
        <property type="entry name" value="AMIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="148"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5491314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="580" mass="62672" checksum="08D4EAAC48C722D0" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG16</accession>
    <name>A0A9W9XG16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine palmitoyltransferase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792222.1">
        <property type="nucleotide sequence ID" value="XM_056932263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG16"/>
    <dbReference type="GeneID" id="81622512"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000004">
        <property type="entry name" value="2-amino-3-ketobutyrate coenzyme A ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="250"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="627"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5491093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="674" mass="73963" checksum="A8021C228EB7F163" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGC0</accession>
    <name>A0A9W9XGC0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792770.1">
        <property type="nucleotide sequence ID" value="XM_056932811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGC0"/>
    <dbReference type="GeneID" id="81623060"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5491642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="298" mass="33629" checksum="CC9C09A56FC50727" modified="2023-11-08" version="1">MMDSEPHLPSGIPGAVVLSAPSISVLKQTANDVYLRLNSDASYTNQFIVVKHITQSLQAFLSEDDNPIGRYTRLTLDKQHQQAVIRVIPSSDHERVTERFLFCLGRKLVDMGVDRNLFYIEGQTRYPGKSCEKEPDQGFTPLASPRDLPEWPSLVVETGLSESEALLRNDAHWWFSNSDYKVNMVLLIYIKKQPKPHVTWQLFHLKSTTTKITRGLQAEVARALSSDTTPAQTASPSKLQPHLAAEMITVTATDVDNTPLILPFEKLMRRSPDPNTKEGDLIFTPEDFHYFCRSVFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGE2</accession>
    <name>A0A9W9XGE2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_001274</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792908.1">
        <property type="nucleotide sequence ID" value="XM_056930877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGE2"/>
    <dbReference type="GeneID" id="81621126"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.100.10:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040822600" description="Glucanase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5492528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="453" mass="48067" checksum="5F7F7AAEBF0D6351" modified="2023-11-08" version="1">MFQRALFFSALMASVGAQQVGTQKAETHPPLTWKECTSSGCTSKDGSVVIDANWRWVHSVDGYHNCYTGNEWDATLCPDDATCATNCAVDGADYAGTYGATTSGDSLSISFVTGSNIGSRFYLMENENKYQMFKLLNKEFTFDVDVATLPCGLNGALYFVSMDADGGLSKYETNKAGAKYGTGYCDSQCPRDLKFINGKGNVKGWKPSANDKNAGVGPHGSCCAEMDIWEANSISTALTPHPCSTDGQTICEGDSCGGTYSTTRYAGTCDPDGCDFNPFRMGNESYYGPGKVVDTKSKMTVVTQFITTDGTDTGSLKEIKRVYVQNGKVIANAVSDVSGVPGDSITSDFCTAQKKTFGDQDVFAEKGGLSGMGKALGEGMVLVMSLWDDHNSNMLWLDGEKYPVDAAATKAGVSRGTCSTDSGKPSTVESESGSAKVVFSNIKVGSIGSTYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGL0</accession>
    <name>A0A9W9XGL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">37S ribosomal protein Rsm22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_001317</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792951.1">
        <property type="nucleotide sequence ID" value="XM_056930920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGL0"/>
    <dbReference type="GeneID" id="81621169"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="36"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="752"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="762"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="786"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="809"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5492571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="818" mass="91328" checksum="9DD229A55D610FFA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH07</accession>
    <name>A0A9W9XH07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5 6">2.5.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_003185</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5 6"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792746.1">
        <property type="nucleotide sequence ID" value="XM_056932787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH07"/>
    <dbReference type="GeneID" id="81623036"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.140:FF:000003">
        <property type="entry name" value="tRNA dimethylallyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030666">
        <property type="entry name" value="IPP_transferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039110">
        <property type="entry name" value="IPP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="438"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="440"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5491618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="480" mass="53965" checksum="A0CA254FED23FC47" modified="2023-11-08" version="1">MDPLITVVGATGTGKSKLAVDLAARFNGEIINGDAMQMYRGLPIITNQIPLNERKDIPHHLLSCVDLDTEAWRIGHFKREALRLIADIRSRGKLPILVGGTHYYTQAVLFKDQLVGEGCDSESETTAKTANETQRLDSTSTSEKWPILDSSPEVLMQKLREVDPVMAARWHPKDGRKIRRSLEIYFQTGRPASEIYAEQQEQKQKAATQTEGGLLRFDNTLIFWVHAEKEILNQRLDARVDGMIEQGMMAEAETMYDFIQQKKAEGVEVDQTRGVWVSIGFKELAPYFAARHEGVLNEDELGTLRSQCIEAIRTATRQYGGSQIKWIRNKLWRALADADMTQRLYLLDSSDVAQWTSRITEPSEDIVRAVKQGASTPDPKSLSALARTILGAREEQGVSSTSPLKAFTCDVCAKTVVGDAQWEIHLNSYGHKRGLKSAARKAERDEYFRKRAMEEQGEGSEKDADAKGTNKRTFDRTENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH50</accession>
    <name>A0A9W9XH50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pseudouridine synthase I TruA alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_001632</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793266.1">
        <property type="nucleotide sequence ID" value="XM_056931235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH50"/>
    <dbReference type="GeneID" id="81621484"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="5">
        <location>
            <begin position="328"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5492886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="614" mass="68816" checksum="17690602190247E9" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHA7</accession>
    <name>A0A9W9XHA7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_001276</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792910.1">
        <property type="nucleotide sequence ID" value="XM_056930879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHA7"/>
    <dbReference type="GeneID" id="81621128"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="423"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5492530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="571" mass="62244" checksum="020061C155BA60D8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHH5</accession>
    <name>A0A9W9XHH5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA ligase</fullName>
            <ecNumber evidence="7">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_001844</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="7"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793478.1">
        <property type="nucleotide sequence ID" value="XM_056931447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHH5"/>
    <dbReference type="GeneID" id="81621696"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000004">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000218">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000018">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF9">
        <property type="entry name" value="DNA LIGASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="10">
        <location>
            <begin position="537"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="624"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="854"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5493098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="874" mass="96675" checksum="846C897BB7606DD4" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHR3</accession>
    <name>A0A9W9XHR3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial F1F0 ATP synthase subunit Atp14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793458.1">
        <property type="nucleotide sequence ID" value="XM_056931427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHR3"/>
    <dbReference type="GeneID" id="81621676"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019711">
        <property type="entry name" value="ATP_synth_F0_suH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10775">
        <property type="entry name" value="ATP_sub_h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12052" checksum="40664A61927C4C77" modified="2023-11-08" version="1">MMSQSLRASRSLLTRASRQQVPVAARRTFLTSAVRRADQVQDLYLRELKAYKPTPVKPSDAEGNEANLASELSAYEAQQVEVEGQSAAGEAAPAEESWFEEDEEEAAAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHS3</accession>
    <name>A0A9W9XHS3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_001839</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793473.1">
        <property type="nucleotide sequence ID" value="XM_056931442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHS3"/>
    <dbReference type="GeneID" id="81621691"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="180"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5493093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="439" mass="48752" checksum="D1ADC9C41BA2A511" modified="2023-11-08" version="1">MFASHPLFSTCKRAAVDSVHRLPRSLSLRTPSAPNPLYQKNLFSSISSSAQKQLGPSDGPADSSDAQKQRRRSSRGPAVPTSLRRVAVEAQRSKDGFISKPQLKEHGVPDHTRVVTAYAVAEKFDIRQVREILQDKGYEPDPLGTGLYPQVVHVQIPIDSIRRVGNPSTDDLPADQVGDVFVFPSGTVVAWSLPEGFTSFLATRTLLPAAEGAHVDNVETEDLEFVEDASRENSVIKGDTIILGTRSSSQALQSLRGSQQSIDTVLTKVAFSSGLARSTKLAVLESLLSNYFESTRSIPTLLSKGSRLPYTRDFILRKTGQLLSVRAQLNLYSELTDSLPDLFWDSRHDLGLEGYYEQVGRALDVGIRIKLLNEKMDYAQEIASVLRERLSETHGLRLEWIIILLIAVEVGFEVLRLWKERKHGQEEVLHKRQPESEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHU5</accession>
    <name>A0A9W9XHU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_002033</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793667.1">
        <property type="nucleotide sequence ID" value="XM_056931636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHU5"/>
    <dbReference type="GeneID" id="81621885"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF220">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040753409" description="alpha-amylase" evidence="16">
        <location>
            <begin position="26"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="17">
        <location>
            <begin position="38"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="13">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="55"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="269"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="467"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5493287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="557" mass="61685" checksum="CDDA007CF972A621" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHW8</accession>
    <name>A0A9W9XHW8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vacuolar iron transporter cccA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002037</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793671.1">
        <property type="nucleotide sequence ID" value="XM_056931640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHW8"/>
    <dbReference type="GeneID" id="81621889"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02435">
        <property type="entry name" value="CCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5493291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="299" mass="32020" checksum="DA9708B0FEA02F98" modified="2023-11-08" version="1">MSITSASGLMSRYSRLSDGRASTDEENEKNMAYKLPRDVEAADNQQRRSGATEKKASRWIDGRTVSDAIIGLSDGMTVPFALTAGLSALGDTKVVVFGGMAELIAGAISMGLGGYLGAKSEEESYKATLKETENQTMVDPDSVSTTIEDIFEPYELPAELVSQLKTHLSASPMLPSFLMNFHHTLPEPSDSRAVMCALTIALGYFIGGFVPLLPYFFVGPEDAFIALRWSIATMAIALFLFGYGKTCFVSGWAGRRNVRKGVIGGFQMVLVGGVAAGSAMGLVKVFQLWANGSGHAKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHW9</accession>
    <name>A0A9W9XHW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_001914</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793548.1">
        <property type="nucleotide sequence ID" value="XM_056931517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHW9"/>
    <dbReference type="GeneID" id="81621766"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050226">
        <property type="entry name" value="NagZ_Beta-hexosaminidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480">
        <property type="entry name" value="BETA-HEXOSAMINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480:SF16">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 3 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="6">
        <location>
            <begin position="537"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="6">
        <location>
            <begin position="705"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5493168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="849" mass="93723" checksum="9E0C2AD405A400A3" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHY0</accession>
    <name>A0A9W9XHY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_001606</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793240.1">
        <property type="nucleotide sequence ID" value="XM_056931209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHY0"/>
    <dbReference type="GeneID" id="81621458"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF11">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10770)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5492860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="298" mass="32510" checksum="0C0BA00B8805E7D2" modified="2023-11-08" version="1">MSERLMLSVGCHAKIPGVGTSYGYVPSLGAGIAFLSLFGLTMVVHTVQLCWKRTWWCVVFSIGALVEILGWAGRTWSAECPYNNTAFLMQISTLIMAPTFFTAGIYVLLGRFIQILGPESSSIKPSLYLWIFCTCDIVSLVVQAVGGGMASGQAGKVGGNTKPGTDVMVAGIIFQLVSITVFVACAADFVRRTLRRRLLQSLNGSVVPLLGAMIFSVLCIYIRSIYRTIELLQGWSGYLITHEKYFIVLDGVMMVLAVGVFNVIHPGWFLPDNKRSGAAKRSDYGWEEAELSSVLGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHZ4</accession>
    <name>A0A9W9XHZ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793712.1">
        <property type="nucleotide sequence ID" value="XM_056931681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHZ4"/>
    <dbReference type="GeneID" id="81621930"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5493332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23674" checksum="E7D49386926E5772" modified="2023-11-08" version="1">MIVWFLLGSTLAGCLIIALYRLLVHPLKKVPGPRLAAVTGLYEVFWIAWSCTSYDEEIDRMHQIYGPIVRINPDEIHIQDDFYQSKGADVACHSWHLESYTPSWQWQTPATLDRLRRWSWWKIRSPLHAEMLGFVQHLVQKHFHYNESRRRAATVASSSGNEILGIRLLLRYDQSPASDLEGGTAARTVPSSVRGRSLSIAVRHPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI10</accession>
    <name>A0A9W9XI10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_002005</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peroxin-14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793639.1">
        <property type="nucleotide sequence ID" value="XM_056931608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XI10"/>
    <dbReference type="GeneID" id="81621857"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000489">
        <property type="entry name" value="Putative peroxisomal membrane anchor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="13">
        <location>
            <begin position="4"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="255"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="180"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="266"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="340"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5493259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="370" mass="39221" checksum="4BC285412A813A47" modified="2023-11-08" version="1">MAPREDLIASAVTFLQDPSVASSPIEKRVAFLQSKNLTQEEVDLALSRVGEDPAAAAAAAGTVSAPPQNSYPSQQIAYRQPLQSPQGYGYPAYNQWQPPPEPPKRDWRDWFIMATVMGGVGYGLYFVGKRYISPLIAPPTPPQLEKDKESIDEQFSRAFDLIEQLSTDTAALKAAEDARTERLDSALKDVENLVADLKNASRRRDDDTRRISDEVKALKDAIPKALEGAREGNENRLKELGSELKSLKVLLGNRLGGSTAGPTVGRTLSSSTVPSATPSQASGETSGSAPSASSGLQATVTPAEQEPLSATVATSSPAPAAESPLAKLGRSASIPAWQMAASNRSKTSSQSNASTTTDQPSNVEQNAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI69</accession>
    <name>A0A9W9XI69_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-nitrophenylphosphatase</fullName>
            <ecNumber evidence="3">3.1.3.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_002204</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57917"/>
            <dbReference type="ChEBI" id="CHEBI:61146"/>
            <dbReference type="EC" id="3.1.3.41"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.41" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793838.1">
        <property type="nucleotide sequence ID" value="XM_056931807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XI69"/>
    <dbReference type="GeneID" id="81622056"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000039">
        <property type="entry name" value="Phosphoglycolate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5493458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="344" mass="37581" checksum="D6FC65D31D21B290" modified="2023-11-08" version="1">MTEAHPASTTTPRYLTGDKAGLREFLDKFDVGSPSPQKKAIFARGLFINQFSPTGLSLRLRRSHFSPGVLWSGDHVFPGTVDTLELLRKNGKQVVFVTNNSTKSRADYLKKLESLGIPSNVEEIFSSSYSSAIYISRILQLPENQRKVYVIGESGIEQELRSESVPFIGGTDPAYRRDIQPEDYKHIAAGDPSILDPEVGVVLVGLDFHLNYFKLALAYHYVKRGAVFLATNVDSTLPNSGTLFPGAGSMSAPLIMMLGRDPVALGKPSQAMMDAIEGKFHFDRSRACMVGDRVNTDIRFGIEGQLGGTLGVLTGVSSKEEFVSGSVQPLAYLDKLSDLLDAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XJ98</accession>
    <name>A0A9W9XJ98_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">RuvB-like helicase</fullName>
            <ecNumber evidence="18">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">N7539_002145</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="function">
        <text evidence="15">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">May form heterododecamers with RVB1. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="18"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793779.1">
        <property type="nucleotide sequence ID" value="XM_056931748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XJ98"/>
    <dbReference type="GeneID" id="81621997"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 18" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 18 20" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="12 18" id="KW-0804">Transcription</keyword>
    <keyword evidence="10 18" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="68"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00065373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ5493399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="469" mass="51359" checksum="B9C6CB0CFEFEBA51" modified="2023-11-08" version="1">MAVPISTVAESKELRGLNLIAAHSHIRGLGVDADSLQPRGVSQGLVGQEKARKAAAVILQMVKEGKIAGRAMLIAGPPSTGKTAIAMGMAQSLGSDVPFTMLASSEIFSMEMSKTEALTQAFRKSIGVRIKEESEIIEGEVVEIQIDRSVTGGNKQGKLTIKTTDMETIYDMGTKMIDSMTKERVMAGDVISIDKSSGKITKLGRSYARSRDYDAMGADTKFVQCPEGELQVRKEIVHTVSLHEIDVINSRSQGFLALFSGDTGEIRSEVRDQINTKVAEWKEEGKAEIIPGVLFIDEVHMLDIECFSYINRALEAELAPIVIMASNRGQAKIRGTTYTSPHGLPLDFLDRVVIVSTQPYSADEIRQILAIRAQEEEIDVSPDALALLTKIGQESNLRYASNIITTSHLLSQKRKAKEVSIEDVQRSFKLFYDPGRSVKFVNQYEQRFIGDHGAVNFSAPSNGDAMEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XL79</accession>
    <name>A0A9W9XL79_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_000149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794046.1">
        <property type="nucleotide sequence ID" value="XM_056929753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XL79"/>
    <dbReference type="GeneID" id="81620002"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5495033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="202" mass="22719" checksum="9F81AC029B20F664" modified="2023-11-08" version="1">MEPRKTPPEYFLEIFADTTTVRDVLKGVLNLIFFHRYFPSIRPVTFDVLDLTLPAINDADLETLIESRVNALVRQHLSPTSANQNGTSSGGGGGVRGRIAVEFYEKKRRRSGLWFGGLAGKGEEEVCWEVWTLDVTIATPRTESERAKVRKAMGNMLQKAALKILTVVNRDKDHIPPITTSDSNPFPYRIVVNPRTDSWGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLA5</accession>
    <name>A0A9W9XLA5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosome-releasing factor 2, mitochondrial</fullName>
            <shortName evidence="7">RRF2mt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Elongation factor G 2, mitochondrial</fullName>
            <shortName evidence="7">EF-G2mt</shortName>
            <shortName evidence="7">mEF-G 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MEF2</name>
        <name evidence="9" type="ORF">N7539_000173</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLA5"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000007">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001636">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03059">
        <property type="entry name" value="mEF_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030851">
        <property type="entry name" value="EFG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261:SF1">
        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="61"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="70"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="155"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="209"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5495057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="890" mass="95917" checksum="3BDFA7EA5FF9B4AF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLL3</accession>
    <name>A0A9W9XLL3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SsDNA binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794146.1">
        <property type="nucleotide sequence ID" value="XM_056929853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLL3"/>
    <dbReference type="GeneID" id="81620102"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000388">
        <property type="entry name" value="SsDNA binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302:SF0">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="15592" checksum="F45F3DF430876D23" modified="2023-11-08" version="1">MSALTSMRPTLGLARTAAQASRNFSSSASRSVARMIITGRLANEPELQSTASGQDILKYTIGTSFGPKDNRQTSWFRVASFLPEGNQRDYIMSLPKGTLVYLEGDASMRSYEDADGKRHSSLNIVQRSLEVLSRPANTSEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLN5</accession>
    <name>A0A9W9XLN5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PQ loop repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_000370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794267.1">
        <property type="nucleotide sequence ID" value="XM_056929974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLN5"/>
    <dbReference type="GeneID" id="81620223"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000005">
        <property type="entry name" value="PQ-loop repeat-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052241">
        <property type="entry name" value="SLC66/Scramblase_ANY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856:SF9">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5495254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30336" checksum="9995E3B2D1D4B591" modified="2023-11-08" version="1">MWLIQQALEYGAPLFLISSPLTSYLDQILSIHRSRSSAGFSLDIPLIMLVASILKVFYWFGEYYSKALLAQAIVMVVVQIALLKVALDNRPAVGARNGIEHAPFTGGSPVGFQRPYDFWQWRNTKPYWLFLAYFFAALFVLHLTPLSESATYISTLGAVGLAVEAVLPLPQIIANHRSGSCKGFRVSVIAAWILGDVMKMSYFFCSQETIPWSFKICGIFQCICDLYLGFQYCLSVGLIPRTFIPSSSWAAGSSVNREGRWGQEEKDIRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMC3</accession>
    <name>A0A9W9XMC3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase2OG-Fe(II) oxygenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_000728</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794625.1">
        <property type="nucleotide sequence ID" value="XM_056930332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMC3"/>
    <dbReference type="GeneID" id="81620581"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="185"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5495612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="351" mass="39205" checksum="A835DB6CA8F3E2B5" modified="2023-11-08" version="1">MPTEKCFDQAPPFPEDVPKLSIPSISLLNLQNGDSETTKEMYEACQVDGFFILDLSESHEGEILLQNAEQMFELAGEVFALGSEILETFAYQPPHDLTGYKSTGKLKTDDGKLDLIEMYNINQDDMVGNSPPRRNPDPIQRHRENIKEFIHLCHSVVTIIQHRLEEQLGLEPDQLSSLNSLHDQSDTSVRLLRTQTQTVTKENLIALGGHTDIGTITLLFNVVGGLQVLPANKENLPANWRYIRPQPNCAIVNIGDTTVEWTGGVLRSSLHRVIKPPGEQAHAVRQSVAYLVRPCQSASMSRLVGGIVPSLQYGERDETRSVKEWAAWRSRQVISGELKPQSRGGILRRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMD9</accession>
    <name>A0A9W9XMD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS allantoate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_000060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793957.1">
        <property type="nucleotide sequence ID" value="XM_056929664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMD9"/>
    <dbReference type="GeneID" id="81619913"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000361">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.2, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF26">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09470)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="73"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5494944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="522" mass="58492" checksum="20E4E9D8A8BFD696" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XME6</accession>
    <name>A0A9W9XME6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Antigenic thaumatin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794674.1">
        <property type="nucleotide sequence ID" value="XM_056930381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XME6"/>
    <dbReference type="GeneID" id="81620630"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF4">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040750650" evidence="2">
        <location>
            <begin position="20"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="208" mass="21410" checksum="9E92AC935526BE26" modified="2023-11-08" version="1">MLYSTLTIPLLSLASVALAVPGSHNVQDALPYGAFPSSSASPSTLSTSAIPKPSSSSSAAATPSTAPAAAQSPASSTGVGKAIIQNHCDTPVYVWSVGSTTPAPAEVSPGSEYSESYRLDHSSGGVALKVSTEEDGLYNSAPMTIFAYNINGQQVWYDLSDVFGDAFKGHPVQLTPAEPAIYWADGVRPAGSQVRVQNASDDLTLTLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMS1</accession>
    <name>A0A9W9XMS1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="9">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_001003</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the BCKDHA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="9"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794900.1">
        <property type="nucleotide sequence ID" value="XM_056930607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMS1"/>
    <dbReference type="GeneID" id="81620856"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000015">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="11">
        <location>
            <begin position="101"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5495887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="453" mass="50888" checksum="A083D001B390CBE9" modified="2023-11-08" version="1">MSSKAILQRSWRATCRSPRMGAPKPTYAPRRWSGSISQRPGSDRVLFPGAVNSKFTTDMSFLKASDLPAIPTYRVIDSDGELVDNSRAPPDVSDEEVLTWYKNMLSVSIMDVVMFEAQRQGRLSFYMVSAGEEGIAVASAAALTPDDVVFAQYREAGVFQQRGYTLKNFMGQLFANCNDTGKGRNMPVHYGQNYPRIHTISSPLATQIPHAAGAAYALKMQDLQNPNRERRIVACYFGEGAASEGDFHAALNIAATRSCPVVFVCRNNGFAISTPTLEQYRGDGIASRGVGYGIDTIRVDGNDVFAVNEAMKEARRLALTDGGRPVLIEAMSYRVSHHSTSDDSFAYRARVEVEDWKRRDNPIIRLRKWLENKGLWNDELEQETRDSMRKAVLKEFSEAEREKKPPLREAFADVYEELTEEAQAQMKELKRILETYPDEYDLRPYKDGVKGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMS5</accession>
    <name>A0A9W9XMS5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anhydro-N-acetylmuramic acid kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_001007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794904.1">
        <property type="nucleotide sequence ID" value="XM_056930611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMS5"/>
    <dbReference type="GeneID" id="81620860"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006040">
        <property type="term" value="P:amino sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005338">
        <property type="entry name" value="Anhydro_N_Ac-Mur_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605:SF0">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03702">
        <property type="entry name" value="AnmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5495891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34421" checksum="D91C2DEF6C86A214" modified="2023-11-08" version="1">MSLGRTAKRSGYCPCQGQARLSALTMAEGCFLAARTGITSVTDFRVSDQAAGRQGAPLIAFFDGLLLHNPTKLRACQNIGGIANVCFIPPDTHGGARECYDFDTGPGNVFIDAVVRHYTDGAQEYDQDGVMGARGTVDQDLVDDFLRHPYFALEPPKTTGREVFRDTLAHELIQKAEAKGRTPDDVVATVTRITAQAIVDHYRRYAPKDVPLDEIFMCGGAHNPNISSYIQQHFPHTQIFMLDSAGVPEDAKEAITFAWQGMEAIVGRSILVRWKLVRSTSWGKWHRGRIIERFNAWACYLRLVETDCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XMU7</accession>
    <name>A0A9W9XMU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_001037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794934.1">
        <property type="nucleotide sequence ID" value="XM_056930641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XMU7"/>
    <dbReference type="GeneID" id="81620890"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5495921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="59" mass="6961" checksum="78272995C8027742" modified="2023-11-08" version="1">MDQIKGAIVKLTYEIRHGFYPELRRKSSHEEIVCAFLEKLSECGNDEHERNQANRNDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN30</accession>
    <name>A0A9W9XN30_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">aromatic-amino-acid transaminase</fullName>
            <ecNumber evidence="9">2.6.1.57</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_001168</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an aromatic L-alpha-amino acid + 2-oxoglutarate = an aromatic oxo-acid + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:17533"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:73309"/>
            <dbReference type="ChEBI" id="CHEBI:84824"/>
            <dbReference type="EC" id="2.6.1.57"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.57" evidence="9"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795065.1">
        <property type="nucleotide sequence ID" value="XM_056930772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN30"/>
    <dbReference type="GeneID" id="81621021"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000074">
        <property type="entry name" value="Aromatic amino acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="207"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5496052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="556" mass="61351" checksum="D908D4C05B0B4A7C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XP44</accession>
    <name>A0A9W9XP44_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc-type alcohol dehydrogenase-like protein YogA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795023.1">
        <property type="nucleotide sequence ID" value="XM_056930730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XP44"/>
    <dbReference type="GeneID" id="81620979"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05188">
        <property type="entry name" value="MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000481">
        <property type="entry name" value="Alcohol dehydrogenase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF3">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="15"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5496010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="368" mass="39215" checksum="129D4C2FC8B685CC" modified="2023-11-08" version="1">MSKAIYISPIDGKPGKPGQVYYPLTVRNLPQPSPQGRELLVKLTAASLNHRDLFLRQHLYPGVSFDVPLLADGVGVVVGAGPQVANAEKWQGKRVILNPGVGWKDSPDGPEEPTGYRIMGGTKVYEKGTLQEYVTIEESEVEEAPAHLSDAEAAALPLTGLTGWRALVSKAGEKNSGKGAVILITGIGGGVALMVLRFAVARGAHVFVTSSSQDKIQKAIDLGAAGGVSYKEDGWDKKLLGMLPSGKKSFDAVIDGAGGDAVEKATRLLKAGGVLSVYGMTVSPKMPFTMQTVLKNIDVRGSTMGSRKEFKEMVDFVASKNIHPVVSRVLKVDIDDLAAIDDLFEDMKQGKQFGKLVIEFGKQNGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJB9</accession>
    <name>A0A9X0BJB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Farnesyl pyrophosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_009587</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785677.1">
        <property type="nucleotide sequence ID" value="XM_056939182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJB9"/>
    <dbReference type="GeneID" id="81629432"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000006">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5466631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="347" mass="39707" checksum="A74CA174968CDFCA" modified="2023-11-08" version="1">MATTTKRADFEAVFPTLAKDILAHAKKYNLPANALEWFEKSLFANTPGGKLNRGLSVPDTGLALLQKPLTDEQFQHLSILGWLTELLQAFFLVSDDMMDGSITRRGQPCWYRHEGVGMIAINDSFMLESSIYLVLKERFRSHPAYIDLVELFHETTWQTELGQLCDLITAPEDKVDLDNFSMEKYMFIVTYKTAYYSFYLPVALALMYLQLATPENLKQSHDILIPLGQYFQIQDDYLDNFGDPSVIGKIGTDIQDNKCSWLINQAIARATPEQRAVLDSAYGRKDKVQEAKVKKIFEEMELEKAYKEYEEKVVGELRAKIAAVDEQSGLKKEVFESFLGKIYKRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJH4</accession>
    <name>A0A9X0BJH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786170.1">
        <property type="nucleotide sequence ID" value="XM_056938793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJH4"/>
    <dbReference type="GeneID" id="81629043"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5469580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="63" mass="7514" checksum="986D14A1351CF30C" modified="2023-11-08" version="1">MRRNGLLRSEPSHFRAVVRTHPVTGEKALFVNPQFYHWEDGQRRHVARLTPRAEPPYETLFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJN1</accession>
    <name>A0A9X0BJN1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="8">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_009277</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="8"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786249.1">
        <property type="nucleotide sequence ID" value="XM_056938872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJN1"/>
    <dbReference type="GeneID" id="81629122"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000003">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="10">
        <location>
            <begin position="103"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="60"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5469659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="217" mass="24599" checksum="9F0C4A34DCE9DE66" modified="2023-11-08" version="1">MAEIHPEQFHAQPHAFNQAPPRPSQESHDNDTKAPLPKGVVLDKDGKPCRTCTSVASWRALTRQATQSSSTPKTDSPTQSTTIATPVTASKSTPQPSEIPSDCPPDVEQLGRSTWTLLHTMAATYPEKASTEHQEDMQGFLKFFSKLYPCWVCADDFRAWMAHPSGRNQPKLGGRKEFGWWMCEAHNEVNRKLGKKEFDCRLWEERWRTGWKDGRCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BMZ2</accession>
    <name>A0A9X0BMZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786893.1">
        <property type="nucleotide sequence ID" value="XM_056937801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BMZ2"/>
    <dbReference type="GeneID" id="81628051"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="265" mass="29378" checksum="479A2A863D7F8250" modified="2023-11-08" version="1">MAMGNSESCNGQTSEDAVKEIQPSTADSFPSTSLYPFSSPASTPSSFMPGRPLQPSIYGDKKGPRVENGLWLAAGIPQQYLINGIPIAGVINEHGIPRPSLRGSGIWPCEETIEEITRMLESDDLPGLREAKSLVHLGGRRTFQLRDAYVWIALRQYDDGSFVISESARNKFAPKWRELLDPESDAPAPTVFDLRKPRLRMAQWREDERGMEQIVKQLNALSADVARLAHQIESVTHILKLANLDNEQSARASHVQAELGQMELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BN44</accession>
    <name>A0A9X0BN44_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rho-type GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_008382</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787074.1">
        <property type="nucleotide sequence ID" value="XM_056937982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BN44"/>
    <dbReference type="GeneID" id="81628232"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09391">
        <property type="entry name" value="LIM1_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09392">
        <property type="entry name" value="LIM2_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04397">
        <property type="entry name" value="RhoGAP_fLRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000033">
        <property type="entry name" value="Rho GTPase activator (Lrg11)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000112">
        <property type="entry name" value="Rho GTPase activator (Lrg11)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000058">
        <property type="entry name" value="Rho GTPase activator Lrg11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF10">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="99"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="163"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="829"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="578"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1083"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1083"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1100"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1121"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1150"/>
            <end position="1168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5475316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1184" mass="131645" checksum="47295FB84990F096" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BN59</accession>
    <name>A0A9X0BN59_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Benzoate 4-monooxygenase bphA</fullName>
            <ecNumber evidence="12">1.14.14.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Benzoate-para-hydroxylase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cytochrome P450 monooxygenase cyp53A1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">N7539_008411</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>benzoate + reduced [NADPH--hemoprotein reductase] + O2 = 4-hydroxybenzoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18033"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16150"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.92"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.92" evidence="12"/>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787103.1">
        <property type="nucleotide sequence ID" value="XM_056938011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BN59"/>
    <dbReference type="GeneID" id="81628261"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018664">
        <property type="term" value="F:benzoate 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000053">
        <property type="entry name" value="Cytochrome P450 benzoate 4-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="7 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ5475345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="515" mass="57714" checksum="A9C661120946584D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNR4</accession>
    <name>A0A9X0BNR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_007784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787250.1">
        <property type="nucleotide sequence ID" value="XM_056937385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNR4"/>
    <dbReference type="GeneID" id="81627634"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289:SF33">
        <property type="entry name" value="SERINE_THREONINE KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="89"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5475497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="403" mass="43443" checksum="D44105E7476C8BFD" modified="2023-11-08" version="1">MAPCDSPVRLTVRTGLHDKRSPPHSPTSASALTPPVTPIGKGVLHAELLTPSPTTEDPSSSTQSSAQTTRHVGVPLIFPDEIDICHDESRRPFEFGRGAWSIVYRARSVPKQSTGSLHTPPSSPASTGRILAVKAPLRRDAHKVLQSEALTMTRLSLTPGCENYMVPFHGFLPEYDALVMSAIPLALSTFIEDKADARKHNPSTATMFEPVQGPDSWRDMARKLITCLAWLHDTAGLVHGDIKPHNVLLRPTVTDTPDAFPFEPLLADFSSAYEIPSDSSSTSNVNQTALSAFTPPFTAPELLSLASLRSGEIAPLPSSDVFSLAATLIAAATGDLLLYPGSNNFQRLAMAKDGHRILDFTRAGSNGCRIPRYGFVEKLIQPAVVKDPTQRILTGDWVALASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNT8</accession>
    <name>A0A9X0BNT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Meiotically protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_007091</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5476947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787491.1">
        <property type="nucleotide sequence ID" value="XM_056936692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNT8"/>
    <dbReference type="GeneID" id="81626941"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5476947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="415" mass="46041" checksum="D4BBD1D0A729F2BC" modified="2023-11-08" version="1">MSPTEEPRPESIDEQERARAAEGDKKTKSRKPAISFVSGCRVTRGPPSDLPKTDQNAVPNRPILTPKSVLPLFFIVGIVFAPIGGVLLWANSQIQEIVIDYSRCSTDAPVTTRADISDKVSATFKSSTANSKYYWQRSQTENGTMCSLFFTIPEAMGPPVYMYYRLTNFYQNHRRYVQSLDLDQLKGKAVSSDTIKGGTCSPLDVNSAGIPYYPCGLIANSVFNDTINTPVRLAENNHTYVMTKQGIAWNSDKELVKKTEYKPGEVVPPPNWSSYNGTYEKTGIPNLQEDQDLMVWMRTAGLPNFSKMSRRNDTTAMEAGDYRLDIIDRFPVTEYDGTKSILISTRTVMGGKNPFMGIAYVVVGGVCVLLGALFTVAYLIRPRKLGDHTYLTWDATNQPASAVASGRDDRMRANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSF5</accession>
    <name>A0A9X0BSF5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788142.1">
        <property type="nucleotide sequence ID" value="XM_056936207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSF5"/>
    <dbReference type="GeneID" id="81626456"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5480712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="127" mass="14152" checksum="19CADD8CD6B83AB0" modified="2023-11-08" version="1">MPCSKDHGNQSFTDDELPLSAHLEVYVESDRKRVQAGDHAGCADDLIAAWRPMETVFDFAGQPSPRGKPVHAVMHDGSTEFGEIVDMNGMNRPGRQGPVKAREHWRLLRLLLMCGVSVQTTPFYPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSR3</accession>
    <name>A0A9X0BSR3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit BET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_006921</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788457.1">
        <property type="nucleotide sequence ID" value="XM_056936522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSR3"/>
    <dbReference type="GeneID" id="81626771"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5481027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="188" mass="21295" checksum="74A9E57E00BE50F4" modified="2023-11-08" version="1">MSSSKASRIGEETRIDKVNAELVTLTYGTIVAQLCQDYDSDYQEVNKQLDKMGYNIGMRLIEDFLAKSGVGRCANFRETADMIAKVGFKIFLNVAPTVTNWTSDNNQFSLIFDENPLADFVELPDDGRAQDELWFSNILCGVLRGALEMVQMQIEAHFVSDILRGDDTTEMRVSLVRYIEDEMPPEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BTX8</accession>
    <name>A0A9X0BTX8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 17">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">N7539_005737</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 17">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 17">Cytoplasmic vesicle</location>
            <location evidence="1 17">COPII-coated vesicle membrane</location>
            <topology evidence="1 17">Peripheral membrane protein</topology>
            <orientation evidence="1 17">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 17">Endoplasmic reticulum membrane</location>
            <topology evidence="2 17">Peripheral membrane protein</topology>
            <orientation evidence="2 17">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Golgi apparatus membrane</location>
            <topology evidence="17">Peripheral membrane protein</topology>
            <orientation evidence="17">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789211.1">
        <property type="nucleotide sequence ID" value="XM_056935339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BTX8"/>
    <dbReference type="GeneID" id="81625588"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000008">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15 17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 17" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0813">Transport</keyword>
    <keyword evidence="10 17" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="19">
        <location>
            <begin position="60"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="20">
        <location>
            <begin position="127"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="22">
        <location>
            <begin position="374"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="21">
        <location>
            <begin position="492"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="18">
        <location>
            <begin position="607"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAJ5483941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="740" mass="82394" checksum="A582FCDB73BF3FF1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUB7</accession>
    <name>A0A9X0BUB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_005946</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the battenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789420.1">
        <property type="nucleotide sequence ID" value="XM_056935548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUB7"/>
    <dbReference type="GeneID" id="81625797"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BATTENIN"/>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
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    </feature>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1263" mass="139784" checksum="043637A9D200A6A2" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BV23</accession>
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        <name type="scientific">Penicillium diatomitis</name>
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    </reference>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5488624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="352" mass="39615" checksum="C2967000920E4DF7" modified="2023-11-08" version="1">MVRQHPADCDCERCDPLPDTLQLLLCITTKNKLSNAEIHIQRKKQERRVAEELRKWSENAPRVDSSQPPESQQLTRSGSSSFSTPSVETLHVTQTILDRFKNSRAFFTHLDIQIMFFWHTYQAIERLTLDPALCLLLAGVMLPFATNAEVRDRATEILQGDRHAREESRALGAKEVSRLLVADGAELRMWDSLKQGTLFIFGSSNIASSRVPPLASSESPSSSPCKPRSAEPCIQRLESVVIVQAPSSPPENTIDRLQSSSPPMDLVDHLQSTSPPPANMVDCLQSHAQRLQLEEDNRYLATRVHQIEAGQNELLEILQTMQHRMAVLEEENRRLKKRLHAAASVCAEPWSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXX8</accession>
    <name>A0A9X0BXX8_9EURO</name>
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        <submittedName>
            <fullName evidence="2">3-dehydroshikimate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791253.1">
        <property type="nucleotide sequence ID" value="XM_056933712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXX8"/>
    <dbReference type="GeneID" id="81623961"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF21">
        <property type="entry name" value="XYLOSE ISOMERASE-LIKE TIM BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="27"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="366" mass="40674" checksum="1FADAC8A5542EB4E" modified="2023-11-08" version="1">MILNRPGIASMSLGKPWVHNLPDKLLQAAAHGFQGIELFFDDLDCYAHRAFNGDHLEAAHQTRTLCNNLGLTIICLQPFSMYEGLLDRAESDRLINDKLPRWFRLARALGTDMIQVPCNFLGPDPQTGAARTTGDRTVIVRDLQRLADLGAGAGFRFVYEALCWGDHVDTWEASWEIVRAVDRSNFGLCLDSFNIAGRVYADPSSASGKTPHAAADMAASLQRLRAAQIDPSKIFYVQLVDGERLASPLDANHPFHVAGQPARMSWSRNARLFPFEESRGGYLPILDIASVFFDDIGFRGWVSLELFSRTLADPSPTTPADHARRGIESYIKMGRLLQWQDHAVTDKIVDLSCQSVGTEAPLQHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY21</accession>
    <name>A0A9X0BY21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790790.1">
        <property type="nucleotide sequence ID" value="XM_056933249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BY21"/>
    <dbReference type="GeneID" id="81623498"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470:SF1">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5488757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="34883" checksum="B44F33B85E3FF6C9" modified="2023-11-08" version="1">MAASHPHLDALQRDGFVVVKNLLSPSEVDHYRSIAATATSKTRTGSWPFFRTVPKQFPPWPTNVPPPAAEGGIWGVQHLLHPEMPGRDEFAKCYFSEAILDIASELMGVASSNPSPGAAASDEEPLVMELFNLLVAPETRDFELRWHRDDISDQLSTDEELQQLAAKSPGGRQSHAQYNLALCPDASLIVIPGSHRRARTAIERSADPYEAVLPDQLVVQLQPGDAVFYDSNILHRGVYKGKTESGEETRLTLHGSLGLKASDAADAETKKVRATAVLQHGVGTWVNRKDAAFGLGERPEKMRANLISMGSGEGVGYSLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYB0</accession>
    <name>A0A9X0BYB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_004561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791704.1">
        <property type="nucleotide sequence ID" value="XM_056934163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYB0"/>
    <dbReference type="GeneID" id="81624412"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="442"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5489671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="690" mass="76574" checksum="C3C77093167A6392" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYV4</accession>
    <name>A0A9X0BYV4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792239.1">
        <property type="nucleotide sequence ID" value="XM_056932280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYV4"/>
    <dbReference type="GeneID" id="81622529"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="309" mass="32795" checksum="25F191C84277691B" modified="2023-11-08" version="1">MSLNFSSPDSLTRLSGLAEEMIKESAQMIRKSDAMPTSTRLQRSIPTYYDGFQDALDNLSEQIFIAKAFLEKEYGAIKAREAVPPPNESVSTTEIGSKTEGISKTTSPAPDNPREEAVKVEPTADESTIAVLTAPVVASSHDKTDEHKTDAEEKEPGTESATNQTIPGTGEGMKYDTGLDGAGAPNSFDLNYDFGNDDSGNQAFLSGTSFGNPTASNDKGGQATAPAKPQAAPTAGGGAFDMELGKTDSHLNSFADHSNGMDDMMGPGESSFDDLFMEADNMGGTGGDLRQLEGNNLMEMNELDDSWFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYW2</accession>
    <name>A0A9X0BYW2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002707</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792269.1">
        <property type="nucleotide sequence ID" value="XM_056932310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYW2"/>
    <dbReference type="GeneID" id="81622559"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="7">
        <location>
            <begin position="89"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="231"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5491140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="277" mass="30616" checksum="3C222DDE3F570BF2" modified="2023-11-08" version="1">MKLLTKEEEDAHYRNVVKGGTIGGIVGLMAGSAGVLLASRRYHTIRNLTIPMKAFLVTSSGTFVGIIAADHASREFEKSQNAAKQWYESREDRLHAEEMRGLSFTDRALAFARREKYKIVGATWVASMIGSFVLVGRNPYLSGQQKIVQARVYAQGLTLAVLCASAAFEISDQRRGKGILDSAKKSKKSQVEDAAEPAPVHSQNNEQADLWKDMVAAEEQRLKSKHQSLHIHHDDNKDEAENKDESSEKSKDESEGEAKENKKDASSGKKNEGEKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZP6</accession>
    <name>A0A9X0BZP6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792526.1">
        <property type="nucleotide sequence ID" value="XM_056932567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZP6"/>
    <dbReference type="GeneID" id="81622816"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5491397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="839" mass="95919" checksum="86E81E52EDA9C95C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C1X2</accession>
    <name>A0A9X0C1X2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_000154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794051.1">
        <property type="nucleotide sequence ID" value="XM_056929758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C1X2"/>
    <dbReference type="GeneID" id="81620007"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5495038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="308" mass="34929" checksum="ED0EE3C0FA76944F" modified="2023-11-08" version="1">MVNPALAQVIIGVSGRIPGHTHIHFALTENRCQIVNINWFLDSAQLNRPLRTAAYLLVASANVAEDLQGPNVPRSNLQIHHEKLITFVDKRCKNGDTIARNEDLDETQPSYWVSTRRIQLLHDFGLKTWFTWVHDECPDTTAMEFRGNGDLDSAKWEFGRAFEECKLAELPLEPARDLQSQQLLPGVERLIKLLFWPDYGIIPFYNHMFVGRFGSGFLKTDGATLRISFDYLTELVEHLAGPSLGPGAPRSSSMMLQSRIATLLKQNYLRLLRIAKRSVPGPEVIDFQWAKHKFQNIELSSSSLHSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2B8</accession>
    <name>A0A9X0C2B8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable electron transfer flavoprotein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_000604</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 10">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794501.1">
        <property type="nucleotide sequence ID" value="XM_056930208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2B8"/>
    <dbReference type="GeneID" id="81620457"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="11">
        <location>
            <begin position="37"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="270"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="284"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="301"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5495488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="355" mass="37039" checksum="81B6F05B6646DA39" modified="2023-11-08" version="1">MIPIARSSVLRAARSQIYAARTLTSPTSSALARLLSTLAVLEQRDGKLQGSYASAIAAAQKLGGPVTAFLAGSGVKGTSAAEAAKIKGLDKVIAVENDAYEKGLPENYAPMLLENIKTGDFTHINFTHIIAPHSAFGKSLLPRVAALLDVQQISDITAIESEDTFVRPIYAGNAILTVQSSDKVKVITVRGTAFQGVELEGGSAEIVDGVDTNAPAQTEWVSEELTKSERPDLATASRVVSGGRGLKSKEEFDRVMLPLADALGAAIGASRAAVDSGFADNSLQVGQTGKNVAPELYLCAGISGAIQHLAGMKDSKVIAAINKDPEAPIFQVADVGLVGDLFDKVPELTEKVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2D7</accession>
    <name>A0A9X0C2D7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794546.1">
        <property type="nucleotide sequence ID" value="XM_056930253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2D7"/>
    <dbReference type="GeneID" id="81620502"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="71" mass="7954" checksum="3FC37A8C0B02E297" modified="2023-11-08" version="1">MSRLRAQDCKYVENIIPDIVYYAKSKLLNAEGGNNLAAEEKAARKNKRSAHVTHTHRAVPSRIESSSNSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2L8</accession>
    <name>A0A9X0C2L8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ribosome biogenesis protein ENP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_000858</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat NOL10/ENP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794755.1">
        <property type="nucleotide sequence ID" value="XM_056930462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2L8"/>
    <dbReference type="GeneID" id="81620711"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="9">
        <location>
            <begin position="19"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="8">
        <location>
            <begin position="413"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="7">
        <location>
            <begin position="558"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="516"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="581"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="704"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5495742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="731" mass="82317" checksum="984CEA07178766C2" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2X9</accession>
    <name>A0A9X0C2X9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794638.1">
        <property type="nucleotide sequence ID" value="XM_056930345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2X9"/>
    <dbReference type="GeneID" id="81620594"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332:SF1">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="318" mass="34396" checksum="A5F64EE552F07160" modified="2023-11-08" version="1">MMSSSFGPGLARRDTNKSTTGYEPTLGSIPPVSGGGGPFGPQSASAIYQQIHDMSAKRISTLNYLRKALEGRVYWYNTVHFSRADINRLPYFEPRKLARRAVNYLLLGISLPLILDVNTSPLEYLKALNALLMEFEAFQQIHPPDGTSSSSLARARIPQMFKRATHAGTKTRRASSATEIGLPMQTSDPSDLKSAAANSTSSAAASVISFALTESSDLLPGEEYTYLLTPSLPFEPDFFETFATLCDVLIDCYGRITALVPNPSVCTVTLGETFSKADARLRKIMVAGAVREFEDASRNGVKNELAGVSRVVLGGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C315</accession>
    <name>A0A9X0C315_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="Proteomes" id="UP001148312">
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    </dbReference>
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        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <location>
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            <end position="35"/>
        </location>
    </feature>
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        <location>
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            <end position="114"/>
        </location>
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            <end position="277"/>
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            <end position="851"/>
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        <location>
            <begin position="915"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="33"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="229"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="818"/>
            <end position="831"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1101" mass="120346" checksum="C11145420C8D8706" modified="2023-11-08" version="1"> </sequence>
</entry>
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    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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            <strain evidence="6">IBT 30728</strain>
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    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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            </authorList>
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            <strain evidence="6">IBT 30728</strain>
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    </reference>
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    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="478" mass="52150" checksum="922D7032D6B331C5" modified="2023-11-08" version="1">MAAIDSFGIDRLRTLLSKSAVILTPDTEGYQESLVRWSDTGRKEAGIVVQPVEYEDVSNVVRWATEHSIDTAVKGGGHSTAGTSSSEGGLVIDLSRMKQVSVDAAEKTIRVQGGATWKEVDEAGAAHGLATVGGTVNHTGVGGLTLGGGYGWLSGQHGLTIDNLLSAKVVLADGSLVTASRTQSQDLFWGLRGAGYNFGVVVEFTFQAYDQSPLVYSGVLAFPPEQLEKVIEVLNSGLASPDARSGAMCIITQAPDGSGPMIVVICFYNGTREEGEARFADLLALTPILNTVDMIPYSEVNTLQNPQATYGDRKSFKGVFYEPPLDTNFIRGVFDEFVAKVNSDKDLIPSAIILEFIDMRKICEVPLSQTAFASRNMTQNGILVMRWSDASKDLDHRNWAREVQKKWKTELDARKRNTLHKNDVPQYINYAEPGDSLVDNIYGANLARLQEIKAYYDPRNIFHKMHPIPLPATGTLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKB6</accession>
    <name>A0A9W9WKB6_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_009501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
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        <lineage>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785591.1">
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        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5466545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="160" mass="17137" checksum="70E326BDD934DDA0" modified="2023-11-08" version="1">MGSVVARPPEEAQASSAPHPMNVCRRKRSTVGASRKLETMSHFRFSAAGKGSFTPIWQTGDQADPSVCPESPPPPKGEGLLPSTIDRNQRTMTMHNDNSPVAMLRSGSARSWITVHQEISPSRFCSGRPVHLYPKLCGILGTPTGWTLSDAMADGAAAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL70</accession>
    <name>A0A9W9WL70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_009147</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786119.1">
        <property type="nucleotide sequence ID" value="XM_056938742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL70"/>
    <dbReference type="GeneID" id="81628992"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="405"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="124"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5469529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="606" mass="67327" checksum="607C2AF10E8A9D7D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQG4</accession>
    <name>A0A9W9WQG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GED domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786357.1">
        <property type="nucleotide sequence ID" value="XM_056938349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQG4"/>
    <dbReference type="GeneID" id="81628599"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5471811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12389" checksum="9DEF1288FD8BBAF1" modified="2023-11-08" version="1">MVHYASVEALDCMPAYYKVTLRPYPKDLCGSDKIQVALKRFLDDIANEIVEGRLMGFLSRILSPVTVFDMPADLVMKIAGELKESQSIREQLNKKLVILEGAQRPANASFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTR4</accession>
    <name>A0A9W9WTR4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5474967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786725.1">
        <property type="nucleotide sequence ID" value="XM_056937633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTR4"/>
    <dbReference type="GeneID" id="81627883"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5474967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="67" mass="7290" checksum="B52E01F365437694" modified="2023-11-08" version="1">MSLAVDMGLMLVATSNDTLVYAIEQGKSLVARVFPLTMSKLLPIAAHDHIAPSQHRRDSQKEADAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTX7</accession>
    <name>A0A9W9WTX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_008327</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787019.1">
        <property type="nucleotide sequence ID" value="XM_056937927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTX7"/>
    <dbReference type="GeneID" id="81628177"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="316"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5475261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="551" mass="62395" checksum="13DE804CD03E1EB2" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU47</accession>
    <name>A0A9W9WU47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein RTM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_008432</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787124.1">
        <property type="nucleotide sequence ID" value="XM_056938032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WU47"/>
    <dbReference type="GeneID" id="81628282"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF31">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5475366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="313" mass="34518" checksum="353F9B4AC6CBBF3C" modified="2023-11-08" version="1">MSDQNQNGGTVFALYRYTPSIPAAVVFAVIFFILAAAQLFLIVRHRTYFFIPFIVGLLFECAGYIARIFSHFNTLALGPYIVQTMLILVAPPLFAASIYMTLGRITVKLGAEEASMIPIRYLTKTFVVGDVVSFLLQMGGGGYMAVGTLGALNIGAKIVIGGLAVQLLFFGFFVIAAAIFHWRVKQQVSRTRIGSYTHGSTARRSGMGSKLTWEKLMWALYVACALILVRSIFRVVEFVEGNDGYVMRREYWLYIFDAALMTLAGASMTVFFPGFLLGRGELKGSSAVEAFSSGEHEMSSRRLRTKHASGNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU62</accession>
    <name>A0A9W9WU62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bromodomain associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_008228</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786920.1">
        <property type="nucleotide sequence ID" value="XM_056937828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WU62"/>
    <dbReference type="GeneID" id="81628078"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="6">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5475162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="216" mass="23633" checksum="CC0CC13F821F0927" modified="2023-11-08" version="1">MSGHNLHNALLRPPIIQILRAQGFHSTRPSVLETLSDLTGQYLMILASATASHAANAHPEDPVPVLEDIYQALLDTGALRPQLREWEEDWAGEEDMRGLDAFLGWITGPAHREIRRIAGFVPSEGDMVDPDAIEKEDYLTSLKKKHSKTGEESRYAGTVLGKDGEEHPIVLDGGLPSIREWGAQVRSRVPLSPVTSETSGVSSAPSHLSDDDRMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WU99</accession>
    <name>A0A9W9WU99_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_007728</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787194.1">
        <property type="nucleotide sequence ID" value="XM_056937329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WU99"/>
    <dbReference type="GeneID" id="81627578"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="12">
        <location>
            <begin position="140"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5475441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="589" mass="64094" checksum="F31D46C49FD8C858" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUB2</accession>
    <name>A0A9W9WUB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphotyrosine protein phosphatase I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787412.1">
        <property type="nucleotide sequence ID" value="XM_056937547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUB2"/>
    <dbReference type="GeneID" id="81627796"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16345">
        <property type="entry name" value="LMWP_ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43428">
        <property type="entry name" value="ARSENATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43428:SF1">
        <property type="entry name" value="ARSENATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="2">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5475659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="132" mass="14120" checksum="5B568AF738C9E0D5" modified="2023-11-08" version="1">MPSVLFVCVHNAGRSQMAAGYLNHLAGDTIEVRSAGSAPVDSINPVVVEAMLEEGVDLTSQKPKILTADAVQASDVVITMGCGDACPFFAGKRYLDWQLKDPAGQGLDAVRPIRDEIRRRVEALITELQPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUI3</accession>
    <name>A0A9W9WUI3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787466.1">
        <property type="nucleotide sequence ID" value="XM_056937601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUI3"/>
    <dbReference type="GeneID" id="81627850"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="81" mass="8569" checksum="F3EB1127BB28D1CE" modified="2023-11-08" version="1">MDKLSGLASKLGGSSHSGGQQNSNAQNEDYVDKALDSAERKYGGGHVDPAKMRSTNEKITDTAREQFEGATGKNVPSKISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVJ3</accession>
    <name>A0A9W9WVJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vezatin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_007672</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vezatin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788072.1">
        <property type="nucleotide sequence ID" value="XM_056937273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVJ3"/>
    <dbReference type="GeneID" id="81627522"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026859">
        <property type="entry name" value="Myosin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026858">
        <property type="entry name" value="Vezatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15989">
        <property type="entry name" value="VEZATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15989:SF5">
        <property type="entry name" value="VEZATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12632">
        <property type="entry name" value="Vezatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin-binding" evidence="15">
        <location>
            <begin position="154"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5477528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="609" mass="66886" checksum="7CB301674DF1D4FA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVZ5</accession>
    <name>A0A9W9WVZ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_007415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477271.1"/>
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    </dbReference>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5477271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="431" mass="47624" checksum="CE28E31FB802F6F4" modified="2023-11-08" version="1">MRSFFNKPEWATKASDPSNTGFYRRSGQTFSDIVAANREARRKQKLAVHSSESASPSPSDEFREAKRPRGSDEHEDKSESKNKKPEVTVAVADEADAETEVEPELAHTAQESEPEAKTRERTPSFAHPDLDSHVGSFQTSDGISRPASPQRPIYIDDSADEQLTPPMSHHTTDIKTTSVDSPRAQGQKDHKSSDSSTLSTMTTTNTTPLPLPTPPPVDDPRVHILITSEIPNTNPLIIQRKMSQALKDARLAWCERQGFTNQEKSTVYLTWQGRRVFDVTTCRSLNIKQEKMSLLDIDDEFDDEEPPSELQIHMVAVTQNPTLLNRRGPSPDAGAGAGAGARGQDASPNTQNDAEDAPMKLLLRSPGLTDFKIKARPSTTVAKIVAAFREKQNISRDKSVDLIFDGDRLESDSCLGDHDVSDLDMLEVLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WW52</accession>
    <name>A0A9W9WW52_9EURO</name>
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            <fullName evidence="4">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Penicillium diatomitis</name>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477361.1"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="RTC4"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
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    </dbReference>
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            <begin position="30"/>
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            <begin position="288"/>
            <end position="301"/>
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    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="47306" checksum="EAE6293863755DCB" modified="2023-11-08" version="1">MQAPHRKLDSSYRAAAGLTRRVNLGRHLLSTYNKPKENEPVVKTETTKTVTQELSLSSDGEELSELSSADMPSEPEFDLPATRKIKTTAQYAASPESSPSHHEENQLRVTQEPAIDDEPISTEEEASDQDSDFQSSKKRPALESYEEKKRTGKGRNPRKESDDESPIFSSWSSQRSKRAKPNTYGSVNIRVPKYVKRPSLSPESGSSGTEASTSKIAQKRTDKQSGISSNGGMLASKKVKSPSSGLAGSSPASKKSTTVPIDTNPYSSHAASSFKEPLSIDLDEDESGFSSLTSPPSSVASEPDEPRQALCPMCKKEVDPQLLELFLAQPKQRVREQERFCASHQQGTVEKEWEANGLPTISWDSFDQRLQKHFPSLEKLLVPDCTSYYRNILEEALKTGKAQNFRLTLSGDGLETISCGYYGTKGSGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2P5</accession>
    <name>A0A9W9X2P5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788703.1">
        <property type="nucleotide sequence ID" value="XM_056935779.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81626028"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
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        <property type="entry name" value="ASST-like"/>
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        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF8">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
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        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040918405" description="ASST-domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="569"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5482731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="622" mass="70832" checksum="B361F5804AEDAF82" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2V7</accession>
    <name>A0A9W9X2V7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">N7539_006314</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17 18">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18 19">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="5 18"/>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788840.1">
        <property type="nucleotide sequence ID" value="XM_056935916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2V7"/>
    <dbReference type="GeneID" id="81626165"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000022">
        <property type="entry name" value="CDP-diacylglycerol--serine O-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016271">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000852">
        <property type="entry name" value="Phosphatidylserine_synth_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ5482868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="232" mass="25467" checksum="04F13560FCCAD6BE" modified="2023-11-08" version="1">MSRRKSNMATSNSNGDGGQEKQKMLLSSEHGHFSLVKALHLADLVTELNVMSVFSSMRYCLGDQSDYSAMWAALGFMPFGLFFDFMDGKIARWRKKSSLMGQELDSLADLISFGLSPAAAAFAIGIRTSLDHFLLAFFVLCGLTRLARFNVTVAVLPKDKTGKSKYFEGTPIPTTLSIASLMGYWVSQGWTHENIPLGVAAQGTIFEFHPVVLLFVLSGCLMVSKTIHIPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2Z7</accession>
    <name>A0A9W9X2Z7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fatty acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788969.1">
        <property type="nucleotide sequence ID" value="XM_056936045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2Z7"/>
    <dbReference type="GeneID" id="81626294"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1050.10:FF:000001">
        <property type="entry name" value="Putative Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094:SF25">
        <property type="entry name" value="SCP2 STEROL-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="17"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5482997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="129" mass="13782" checksum="9B7972D36D082A92" modified="2023-11-08" version="1">MPLKKDSFPASAAFDAINEALQSDAAERKDAVNKAKAIVTFNLKNEKGEEASWYLDLKNKGEVGQGAAPAGGKADVTLTLSDKDFESLVTGKANAQRLFMGGKLKIKGNIMKATKMEPILKKAQGKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X342</accession>
    <name>A0A9W9X342_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788959.1">
        <property type="nucleotide sequence ID" value="XM_056936035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X342"/>
    <dbReference type="GeneID" id="81626284"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5482987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="159" mass="18122" checksum="8915EFFC7DF69C39" modified="2023-11-08" version="1">MLTHNLLKKKKYSHDIQTCLDIPVPLSMKELVRAPPVCLPTRGDLETIEILEEFGKALLRPEDEITQAQNLSAGFSDIVLLLERTLHRTNHKFDDTFEDFVGNCKTLWAVDELIRVATKGARSIHTVTVLDAFSFQPHQYATEQDEQCHKVLAQILRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3B2</accession>
    <name>A0A9W9X3B2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_006407</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788933.1">
        <property type="nucleotide sequence ID" value="XM_056936009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X3B2"/>
    <dbReference type="GeneID" id="81626258"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF155">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="26"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5482961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="362" mass="39530" checksum="B5985BD4616F08C9" modified="2023-11-08" version="1">MQNGKGESLEKGIWAAVIISAVIVALRIFAKIKIKRFAADDILMIFAQILIIVSTAFLSLSVRHGFGINLSHLEAADREAVLKYIAIQIPLVTISTTTARTAFIIYLLAVLGTNKGYRIALWVLCVIQAAGNIASAVLPLSICKDARALWSLEAAIHTTCGDVKAVINFAYYSNTFNSATDFFLAVFPAVVFWNLNLKLRIKVGLILLLSIGFVAMIASIIKTTKLDTLPSVTDIGVDGATELIRWGYVENSIIIITSSIPCIRPLIISSVRKFSSVTRSYELSGPFSGHRTGQNETHHSKMARRFTKSHNLENCSVERILDPSTTHTSTTVGGRSESPEGYPGITKQVEITVISGEHQSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3I8</accession>
    <name>A0A9W9X3I8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_006326</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788852.1">
        <property type="nucleotide sequence ID" value="XM_056935928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X3I8"/>
    <dbReference type="GeneID" id="81626177"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000145">
        <property type="entry name" value="Putative RNP domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000232">
        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000280">
        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="112"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="230"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="394"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5482880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="498" mass="53264" checksum="FC70FB0642DE3A82" modified="2023-11-08" version="1">MSSQYPDYSYSMADRPQQRERSRSPRRRSSRSPRRTRRSYSPRSRSRSRDDYRRSDRDRRSRSPLHNAGAAGSAGSPFAGRNSYVPARNFEDRSAAKENMMQSVRDSSQQDRRVYVGNLSYDVKWHHLKDFMRQAGEVLFADVLQLPNGMSKGCGIVEYATREQAQNAVATLSNQTLMGRLVYVREDREAEPRFIGGPPRGDFGGGARGGFGGSFGGAPGGGGAPGGGGRQLYVSNLPFNVGWQDLKDLFRQAAQQGTVIRADVHTDPTGRPKGSGIVAFESPDDARNAIAQFNGYDWQGRPLEVREDRFAGGGPGFGGRGGFGGGFGGRGGFAGGRGGFGGRGGFGGGFGGRGGFGGAPSGGFGGGGAFEAPVASVPPNPFTDFATSGGDRSAVIYVRNLPWSTCNEDLVDLFSTIGKVDRAEIQYEPNGRSRGTGVVEFDSPDTAETAIAKFTGYQYGGRPLGITFVKYVTPPSGPAVMDAPRPAEPMPMTQDQMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X3M6</accession>
    <name>A0A9W9X3M6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_007080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788616.1">
        <property type="nucleotide sequence ID" value="XM_056936681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X3M6"/>
    <dbReference type="GeneID" id="81626930"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039772">
        <property type="entry name" value="Bin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010675">
        <property type="entry name" value="Bin3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024160">
        <property type="entry name" value="BIN3_SAM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315:SF0">
        <property type="entry name" value="7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315">
        <property type="entry name" value="BICOID-INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06859">
        <property type="entry name" value="Bin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51515">
        <property type="entry name" value="BIN3_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bin3-type SAM" evidence="7">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5481186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="243" mass="27474" checksum="DC59AE60F35804EF" modified="2023-11-08" version="1">MTEPQRPDLSEATELSRAERFKATHLAARHGNYHQYYAKFRAPTVPDERLSILPSEILRNARVIDLGCNAGKLTYEAIAHCGAAVAVGVDIDPWLIEQAKATYPDGPCTFEHFDFVDTSAYKGTALGKFDVVLLLSVTKWIHLNNGDAGILALFAHIRDILNEGGYLVVEPQPMSNYARASKKNKELRETYKTIEIQPPFDDELKTQGFDRILKYERDEEGFARPVHVWRKKSHKIANGDDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X464</accession>
    <name>A0A9W9X464_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IucC family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788871.1">
        <property type="nucleotide sequence ID" value="XM_056935947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X464"/>
    <dbReference type="GeneID" id="81626196"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="IucA/IucC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="L-2,3-DIAMINOPROPANOATE--CITRATE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384:SF5">
        <property type="entry name" value="L-2,3-DIAMINOPROPANOATE--CITRATE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aerobactin siderophore biosynthesis IucA/IucC N-terminal" evidence="1">
        <location>
            <begin position="264"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal" evidence="2">
        <location>
            <begin position="401"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5482899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="574" mass="64373" checksum="31D1B9F3482558FB" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5C7</accession>
    <name>A0A9W9X5C7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789341.1">
        <property type="nucleotide sequence ID" value="XM_056935469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5C7"/>
    <dbReference type="GeneID" id="81625718"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5484071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="469" mass="51971" checksum="781171F01CAF5F2A" modified="2023-11-08" version="1">MVGHVKQLNLDLDSSRLGGCLFDRTHRIHHTHQTHSRRPTIPSLVSFALGPSRAAFRRPSFFFLVDVVSRLWDSSEWSAALTVLLHPDLTPLTPGRCDSQSTRFILSHPAPPSSRKTAALNKPDMPALFPHNASPPKVDLASANSQFCQFPISASASSSLYTLSLSRKRPRRDAEKLATKFQASSEVASASALLQPTYPYSTGYGGVDLDYRPNRYRESFLPPSLENSVESIDDNSLGTSRKRTRRDSLLTSPGPDVDSPESGPIGWGRTVINVVGKVLDLCWSGAFRGFYAGGGQGYDLPTSLPSDTTPSWEKESMLSEKEKECLFHSPIPGQYPEDELERSWVVIPSTTTHEFTPDLAATRSMRSRRVHQASSPRRRSAVMPKSQKKTSASRGSSTPTQSPSLPSPRLREGPDSAEMKRVAAQIRRREREEDASIKRLNRQLQAMIREGKQALGSKVEVDDLEMDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5E5</accession>
    <name>A0A9W9X5E5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable glucan endo-1,3-beta-glucosidase eglC</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Endo-1,3-beta-glucanase eglC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Laminarinase eglC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">N7539_005829</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789303.1">
        <property type="nucleotide sequence ID" value="XM_056935431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5E5"/>
    <dbReference type="GeneID" id="81625680"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000233">
        <property type="entry name" value="Probable glucan endo-1,3-beta-glucosidase eglC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF13">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE EGLC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0134">Cell wall</keyword>
    <keyword evidence="17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 24" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040882754" description="Probable glucan endo-1,3-beta-glucosidase eglC" evidence="24">
        <location>
            <begin position="19"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="337"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="23">
        <location>
            <begin position="349"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAJ5484033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="502" mass="48834" checksum="D2F301E893467AA7" modified="2023-11-08" version="1">MFSKQAIALAFSVAAAQAAHQGFNYGSTLPGGGVAYEADFKTQFQTAKNLVGTSGFTSARLYTMIQGGTTNEPIQAIPAAIAEETSLLLGLWASGGNIDNEIAALQSAISTYGDAFGKLVVGISVGSEDLYRNSVTGAKNHAGIGLNPDVLVEYIKKVKAAIAGTPLSGASIGHVDTWDAWTNGTNAAVINEIDWLGFDGYPYFQTTMPNGIDQGKALFDDAVAKTKSVAQGKEVWITETGWPVSGPTENEAVASVANAKQYWDQVGCPLFGETNTWWYILADAGASPSFGISSSISNTQPLFDLSCKSSSSSSSSAASSATNSAVNLGAGHSTATSAAASSTSTGSNSGSGSGSSGSGSSGSGSSGSGSSGSGSSGSGSSGSGSSDSGSSMGGHSTTMVSVPAGQTPTSASSTPLISSAGTPSSSAAMGSSGASTTGSASGSSGAGAGSSGTSASGSSSGSAAGSSSSASSSPYVGFNSAARSSGSAFSALAAALVLAIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5R9</accession>
    <name>A0A9W9X5R9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WD repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789551.1">
        <property type="nucleotide sequence ID" value="XM_056934357.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81624606"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049567">
        <property type="entry name" value="WDR59-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="115"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="202"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="677"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="930"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1010"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1156"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1315"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1389"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="708"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="941"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1010"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1021"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1334"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1361"/>
            <end position="1375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5484767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1424" mass="156198" checksum="18DB48060258CA27" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6D3</accession>
    <name>A0A9W9X6D3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789937.1">
        <property type="nucleotide sequence ID" value="XM_056934743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6D3"/>
    <dbReference type="GeneID" id="81624992"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="538" mass="57776" checksum="6834330AF0F42765" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6H1</accession>
    <name>A0A9W9X6H1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_005155</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789951.1">
        <property type="nucleotide sequence ID" value="XM_056934757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6H1"/>
    <dbReference type="GeneID" id="81625006"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000044">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="51"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="627"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5485167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="767" mass="85153" checksum="5D42EEC92ACF9437" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6X2</accession>
    <name>A0A9W9X6X2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_005571</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790367.1">
        <property type="nucleotide sequence ID" value="XM_056935173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6X2"/>
    <dbReference type="GeneID" id="81625422"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF78">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="55"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5485583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="536" mass="59966" checksum="BD44BE159E301A90" modified="2023-11-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6Z0</accession>
    <name>A0A9W9X6Z0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="14">TC-AMP synthase</shortName>
            <ecNumber evidence="3 14">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 14">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_005601</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame. Also involved in telomere replication. Binds to single-stranded telomeric (ssTG) DNA and positively regulates telomere length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the SUA5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3 14"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790397.1">
        <property type="nucleotide sequence ID" value="XM_056935203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6Z0"/>
    <dbReference type="GeneID" id="81625452"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000008">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="16">
        <location>
            <begin position="38"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5485613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="434" mass="46564" checksum="BAB0B6F01039E71B" modified="2023-11-08" version="1">MATQETRVVSIERLQQGPGPRTLAEWWADEAKPQTPEAKVIEEAAQLLRTSDIPVAFPTETVYGLGADATRSAAVQGIYRAKQRPSDNPLIVHVDSLDMLTRLLNPSSPTPSSPSSTKTPRIQIPEIYHPLVERFWPGPLTIILPNPSGSELAPEVTSSLTTFGVRMPKSPLARLLIHVADRPLAAPSANASTKPSPTTAQHVYHDLHGRIDLILDGGPSGVGVESTVVDGLCHPPAILRPGGIGLEELRSCPGWENVTLGYHDGTLDAKEIPRAPGMKYRHYSPKARVVLFESGSSVAGVARRVRKDLSDSAIGAHSIGIVRTRMWPQGLNLLPTDDLASSLRPVPSAIEHLQSFPVPGQEMGSPSSRTKLAYDYHLGSDTQSIAHGLFAALRALDELETDVIYVEGIADADGDLAAAVMNRLRKAAGAELKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCD7</accession>
    <name>A0A9W9XCD7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTP-binding protein rhoC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_003704</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790847.1">
        <property type="nucleotide sequence ID" value="XM_056933306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCD7"/>
    <dbReference type="GeneID" id="81623555"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032506">
        <property type="term" value="P:cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000678">
        <property type="entry name" value="Rho GTPase Rho4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="12"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5488814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="282" mass="31097" checksum="722A0A06AD8B0110" modified="2023-11-08" version="1">MSQAYEDQFYAASRRRSVATPPPSLTPRHNRARSQSVRVSNGTASTHTSFSSAQMSEATNITQPPSYSKKFVVVGDGGCGKTCLLISYSQGYFPEKYVPTVFENYITQTTHRASGKTVELALWDTAGQEEYDRLRPLSYPETDLLFVCFAIDCPASLENVVDKWYPEVLHFCPTTPIILVGLKSDLRNKRTCIELLKTQGLTPITPEQGRGVAQRMGATYAECSSKEMRGVDEVFAKAVDTVVAIEEDDYVTQPTSNRNSSKPSGGGVRPGKKVKKRSCSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCD9</accession>
    <name>A0A9W9XCD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790813.1">
        <property type="nucleotide sequence ID" value="XM_056933272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCD9"/>
    <dbReference type="GeneID" id="81623521"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5488780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="367" mass="40820" checksum="86AFBD0777B8603E" modified="2023-11-08" version="1">MPRTLPWLIHKGNASPVKQQSRPRKRAKRECTPVDDDDNDNATSRGPPKTPEKRDFFRSSQTPPSSPARQCPPQEFLLEGLDHDDAWIMVEDEFYAIALSFTQHLHYAEYIRRKKEARSRGTQGLNNLQRPTDGRTALPKESERKKEAESLHARQQAGLADIKPLEEDLDDDDDTTWAGTHLHGLMTSPRKSRSLMGVYGVKSATRAAAGYKQAGGSGGRAAGGDLPRERVSKQRAATDKMADLDGETASDTDDLNGDTDPGEETEGGEDDDDLEELAPAQYERSTVSTSKSIVRPDRQEMDNAVQVQRVAPAVQTSSRFRSRVQSLFDDLDGLPEPSQCVKVEKNTKVSSDPEIQPFRNLQTTRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCI3</accession>
    <name>A0A9W9XCI3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_003770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790913.1">
        <property type="nucleotide sequence ID" value="XM_056933372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCI3"/>
    <dbReference type="GeneID" id="81623621"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="32"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="587"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="599"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5488880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="617" mass="68505" checksum="ECB803DDB1E46D52" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCU1</accession>
    <name>A0A9W9XCU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Polygalacturonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_003433</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790576.1">
        <property type="nucleotide sequence ID" value="XM_056933035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XCU1"/>
    <dbReference type="GeneID" id="81623284"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF13">
        <property type="entry name" value="ENDOPOLYGALACTURONASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="75"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5488543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="112" mass="11482" checksum="BB0F20CCA5DD06B5" modified="2023-11-08" version="1">MSGSPITLQATLGALMNANGTRWWDGKRSNGGKTKPKFFFAHSLDDSSITGQQILDTPVQAFGIQSDNLVLSGIHIDNPAGDSNGGDDTDEFDISDSTGGTVGAAASGPGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XD14</accession>
    <name>A0A9W9XD14_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791052.1">
        <property type="nucleotide sequence ID" value="XM_056933511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XD14"/>
    <dbReference type="GeneID" id="81623760"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="487" mass="55594" checksum="031E46DC51ED8655" modified="2023-11-08" version="1">MADQARSRPAWMPPTAELAFAMAIVKLKPVGITVKDHIFAIRENVKKVDDSKPHLSDKFWDSAAHWRNAFLKSETEQTKLHNRIFELEQKNTELNLKLNIAGPSLKREIEDFEVELTTARKRSKKNEPNAYSRDYIRFHHTYKGVSFLRHMVILTRALQVKRVKRDKMKMLAAHSADLCKQAERGVLTVIQSQIETMLSLRDPQPWKYKEPKLSAVVKAVEMSWLLLQQVLVKTKSPTDASDPRKQVVYFMVCLFESIATALAQYCKALAKVNMVMPGPAASKKKQTKNVFEPSEDRSGTEYVLTGLLAALVRSLDLSEEPCRAVLEGMLYTIVNRVGQMLAFYSFDGMALPHLSIPDLKPPRGLEEMQRAGMTPEWAEIEARQLVLFLRKISITGNCFSADRFTGNRSQVDMRKQLQTKMTNQLLTAVFGEAEPDFHNRLTRASTPPPNEDVMPKDDSSTFKEWFVQHVWHLIGWECLAKMETDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDE2</accession>
    <name>A0A9W9XDE2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_004119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791262.1">
        <property type="nucleotide sequence ID" value="XM_056933721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDE2"/>
    <dbReference type="GeneID" id="81623970"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5489229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="393" mass="44121" checksum="75C1F3611E1B602A" modified="2023-11-08" version="1">MAQSGKYLLVSFPTSIVPSHHRDDALDAVSATVSPENGSVASFAIPEFKIGTLDALVQQADELAKLEGSCQGVVAKVGDALKNILEGDEAQIERMKVYLRTFSWNKVKYRADKSLAELIDLLHKEAASIDNDIRSKYSQYNQVKNTLATLQRKQTSVDRAPSPTTNSNDQANSLASVIDPRSIVQNSEYIETHLVAVPNQLVKDFLKTYETVAPMVVPRSAQLLAEDSEFSLFAVTVFKKHSLEFVHKCREQKWIPRDFKYVEGGKEEERKEVERVGGDERKLWGETLRLGRTAWSEAVMVWIHILVLRVFVETVLRYGLPLDFVCGLVRSPSSKQADKAKSNLEAKYSYLAGNAFGRDKKGRVKRDDPSEMHAAGEGSADYTPYVFYEFEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDY5</accession>
    <name>A0A9W9XDY5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791545.1">
        <property type="nucleotide sequence ID" value="XM_056934004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDY5"/>
    <dbReference type="GeneID" id="81624253"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="94" mass="10147" checksum="299A32C3BC8AE234" modified="2023-11-08" version="1">MNPIRQSVRRLGSTKQYPLSTARLQAARTGPQRRSYATSPSELADSKGTPMWIYGAIAAGAGSMLYLWRKGNAKAKAEAGVTQLEHQRDGGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDZ5</accession>
    <name>A0A9W9XDZ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_003882</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791025.1">
        <property type="nucleotide sequence ID" value="XM_056933484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDZ5"/>
    <dbReference type="GeneID" id="81623733"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000014">
        <property type="entry name" value="PUS4p Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="7">
        <location>
            <begin position="69"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="229"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5488992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="397" mass="44514" checksum="9114483ED38CB5BC" modified="2023-11-08" version="1">MSGEKIFEGCFAVHKPQGISSADVLRDLQRHFNPSKLFRPWLDAEKDFRMKENSYQKNRRRNRNKKIEVKIGHGGTLDPLATGVLIAGVGKGTKSLSEFLACTKSYEAVVLFGAETDTYDRLGKIVRRAPYEHITREAVEKALDQFRGKIMQRPPIFSALRIDGKRLYEYAREGKMPPVEIKARPVETVELKIVEWYEPGTHEYKWPEQEMTGDEKVIAEKLLDKEAELPVEDGAAENDSSAISKRKTPPAAESPIASAGEEATKKQKVSEDESAEVVASTTEPEATVSDSKAADVPTEQADKPRPQPAAVKIHMTVTSGFYVRSLAHDLGKAVGSCALMSELVRSRQAEFELKPENVLEYKDLEQGEEVWGPKVQRFLEDWERKRAAKAEAEEQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE78</accession>
    <name>A0A9W9XE78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_004601</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791744.1">
        <property type="nucleotide sequence ID" value="XM_056934203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XE78"/>
    <dbReference type="GeneID" id="81624452"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF51">
        <property type="entry name" value="SNF2-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="959"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="880"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="911"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1150"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1189"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1213"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="913"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1160"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1194"/>
            <end position="1203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5489711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1271" mass="143427" checksum="972F86941B251345" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEP9</accession>
    <name>A0A9W9XEP9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MT-A70-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791536.1">
        <property type="nucleotide sequence ID" value="XM_056933995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEP9"/>
    <dbReference type="GeneID" id="81624244"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF4">
        <property type="entry name" value="N(6)-ADENINE-SPECIFIC METHYLTRANSFERASE METTL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="57311" checksum="953D440AEEC51BD8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEY7</accession>
    <name>A0A9W9XEY7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription initiation factor TFIID subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_002553</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792115.1">
        <property type="nucleotide sequence ID" value="XM_056932156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEY7"/>
    <dbReference type="GeneID" id="81622405"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000069">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5490986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="32030" checksum="3F1D317502B0A6C3" modified="2023-11-08" version="1">MASPHPTQGSAPATQPLTPPAEAPTTNGISGSAAATTTTTNSQPAAPTSATAPTTSTAPSSHVPGTSLQDSGKSRRPRDVRLVHMLLASLGVTAYQDRVPLQLLDFAYRYTSNVLQDAVHLATEGYAAAVPDTTGTSKGAPSAETNGVSLPALRLAIASRLHYQFQTGLPKEFLMDVASERNRIALPGVSRGFDPAASVNGNAPAANANQSIMMAGMRLPPERFCLTGTGWTMKDEWDSEGEEQEEEGLPDAPQQQAKGSEAAKTGEGAEEEGGDEDEGDGKMEDIFGEDTAMGEAGEADEDQKMGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEZ2</accession>
    <name>A0A9W9XEZ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Nitrite reductase [NAD(P)H]</fullName>
            <ecNumber evidence="19">1.7.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">N7539_002597</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>NH4(+) + 3 NAD(+) + 2 H2O = nitrite + 3 NADH + 5 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24628"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.7.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>NH4(+) + 3 NADP(+) + 2 H2O = nitrite + 3 NADPH + 5 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24632"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.4" evidence="19"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792159.1">
        <property type="nucleotide sequence ID" value="XM_056932200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEZ2"/>
    <dbReference type="GeneID" id="81622449"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015980">
        <property type="term" value="P:energy derivation by oxidation of organic compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19943">
        <property type="entry name" value="NirB_Fer2_BFD-like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19944">
        <property type="entry name" value="NirB_Fer2_BFD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03529">
        <property type="entry name" value="Rieske_NirD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000007">
        <property type="entry name" value="Nitrite reductase [NAD(P)H] large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1100:FF:000002">
        <property type="entry name" value="Nitrite reductase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="entry name" value="BFD-like [2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052034">
        <property type="entry name" value="NasD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02378">
        <property type="entry name" value="nirD_assim_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809:SF1">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13806">
        <property type="entry name" value="Rieske_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="22">
        <location>
            <begin position="891"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1035"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="23">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00070300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAJ5491030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1058" mass="117675" checksum="FC8050C1B2E74D71" modified="2023-11-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF67</accession>
    <name>A0A9W9XF67_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0160 protein MYG1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_004497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791640.1">
        <property type="nucleotide sequence ID" value="XM_056934099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF67"/>
    <dbReference type="GeneID" id="81624348"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="359" mass="39388" checksum="D959612310DC0105" modified="2023-11-08" version="1">MAEETATKKLKTSSPLIGTHSGHFHADEALAVYLLRLLPTYASSPLLRTRDAAQLETCHTVVDVGGVYDASINRYDHHQRTFDTVFPQHKTKLSSAGLVYMHFGRAIIAQHMSLPEDHADVDLLYKKLYADFIEAIDANDNGISAYDQSAVAAAGLEKRFKDYGVTLASIVGDMNNPDPTSPPGEPQDEDSLFGRASTLIGKVFTRKLHHAAKSWLPARTTVGNAYASRTEVHPSGRIMVLPKGGVPWKEHLYNFERENSAAADSQVYYVLYPESAAEDSKWRVQCVSTSESSFESRKPLPEAWRGVRDQDLDGLIASESEKNGQAKLPEGAIFVHASGFIGGHKTKEGAMAMAVRSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFA1</accession>
    <name>A0A9W9XFA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_002766</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792328.1">
        <property type="nucleotide sequence ID" value="XM_056932369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFA1"/>
    <dbReference type="GeneID" id="81622618"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06421">
        <property type="entry name" value="CESA_CelA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050321">
        <property type="entry name" value="Glycosyltr_2/OpgH_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867:SF7">
        <property type="entry name" value="CELLULOSE SYNTHASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="9">
        <location>
            <begin position="201"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5491199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="614" mass="68744" checksum="7C7AE5DC2CC95BDD" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFJ4</accession>
    <name>A0A9W9XFJ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792469.1">
        <property type="nucleotide sequence ID" value="XM_056932510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFJ4"/>
    <dbReference type="GeneID" id="81622759"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF42">
        <property type="entry name" value="MMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="136" mass="14516" checksum="2A6F337B3AC58D0E" modified="2023-11-08" version="1">MSIPKTAVKSPHAPAPPPFLSQAIVMGDYVFCSGQIGSDPKTGTLVQGSIQDRTTQIMSNLSAVLESAGTSLRNVVKCNIFLTSMSDFGAVNEVYMTFFSAPMPARTCVCVKELPMGTDVEIECIAGVRNVPEQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFS8</accession>
    <name>A0A9W9XFS8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792589.1">
        <property type="nucleotide sequence ID" value="XM_056932630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFS8"/>
    <dbReference type="GeneID" id="81622879"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5491460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="100" mass="11833" checksum="895DC7536F53EF39" modified="2023-11-08" version="1">MPPIEIKANGLPDLTNLVSWVYMSAKLEPEKRKKNPQFAWIRPRETKVRPFLAKLGYANIPVIYFRLGKKFFLPKLYQKMILDLRTKVILFSKKKYLSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFZ7</accession>
    <name>A0A9W9XFZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792367.1">
        <property type="nucleotide sequence ID" value="XM_056932408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFZ7"/>
    <dbReference type="GeneID" id="81622657"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="379" mass="41094" checksum="FE56A85D0FEEF6C8" modified="2023-11-08" version="1">MRYVLFSLSAFALYAIFYFAHINGLDELAGEAVASGKLPGVNAPIRTHFTGVKSVDHVLTVLTAFFYPFLDGQSPALLLHGVGFSGAFGAAWTLVVLESWRRGNAGTVAAYPAIFGLVAQLMTFAFATPLLLGLHLGCSVTARRPTADNIQVPRVVLAVLPFVFLIGYMVPTQTMVLPAPSTISIDMKQLAIAFWQPWPAYVSILTTAAYYALSPFFHKSHRASMSSLRWVYASAFANATVAHLITLVVSVASLVAPAIFNPQHVNQFHPSKVFVIAFPWSGVKVQTVAEGVHYFLRWDYLIGSVGVLLWACKLYTVAHKQILSTVSVTGLLVKVALLTVVSGPVGAAVELMWERDELVFKETSSAGTGLRNVATKKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGB5</accession>
    <name>A0A9W9XGB5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Malonamoyl-CoA synthetase vrtB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_002659</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792221.1">
        <property type="nucleotide sequence ID" value="XM_056932262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGB5"/>
    <dbReference type="GeneID" id="81622511"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05943">
        <property type="entry name" value="AACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002937">
        <property type="entry name" value="PRK03584.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="6">
        <location>
            <begin position="44"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="111"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5491092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="692" mass="76395" checksum="15C011DF55586062" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGG5</accession>
    <name>A0A9W9XGG5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_003253</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792814.1">
        <property type="nucleotide sequence ID" value="XM_056932855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGG5"/>
    <dbReference type="GeneID" id="81623104"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000016">
        <property type="entry name" value="Proteasome subunit alpha type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5491686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="262" mass="28860" checksum="264F156881F7B34F" modified="2023-11-08" version="1">MFRNNYDNDAVTFSPQGRIFQVEYAQEAVKQGSVVVGLVNKTHAVLVGLKRNAEELSSYQKKLIEIDSHMAIAIAGLASDARVLSNFMKQQSLGSKMTYGRPIPVERVVNQIADRAQTNTQHYGKRPYGVGLLVAGVDDAGPHLFEFQPSGMIQEMVACAIGARSQMARTYLERNLDQFADCSRDQLINHGLRALKETLSQDKELTVDNTSVGVVGLAPEGSKARIESFKLYEGQETLPLLEALERSESSGTMEEESMEVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGL1</accession>
    <name>A0A9W9XGL1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Mitochondrial respiratory chain complexes assembly protein YTA12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">N7539_001352</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792986.1">
        <property type="nucleotide sequence ID" value="XM_056930955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGL1"/>
    <dbReference type="GeneID" id="81621204"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1690.20:FF:000003">
        <property type="entry name" value="Mitochondrial inner membrane AAA protease Yta12, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="424"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="156"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="846"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="164"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="865"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ5492606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="878" mass="97905" checksum="86AFF56FC5F31788" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH63</accession>
    <name>A0A9W9XH63_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 15">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_001679</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S26B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 15"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793313.1">
        <property type="nucleotide sequence ID" value="XM_056931282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH63"/>
    <dbReference type="GeneID" id="81621531"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5492933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="191" mass="21055" checksum="83A4BB5F9096AE6E" modified="2023-11-08" version="1">MLSFLSNSLNNARTTVAQVLNFALVLSTAFMLWKGLSVASASNSPIVVVLSGSMEPAFQRGDLLFLWNRSPRTEVGEVVVYNVRGKDIPIVHRVVRTFPEIEGKAKKVVKEVTADSTSSHMLLTKGDNNVADDTELYAQGQDHLNRAEDIVGSVRGYIPMVGYVTIMLSEYPWLKSVLLGIMGLMVVLQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH88</accession>
    <name>A0A9W9XH88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_003320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792881.1">
        <property type="nucleotide sequence ID" value="XM_056932922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH88"/>
    <dbReference type="GeneID" id="81623171"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5491753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="184" mass="20074" checksum="3EFD70A6D6E5BC75" modified="2023-11-08" version="1">MGRARQRFPGFEQSGGIWITLDPGQPDAYDGALQLAQRTGVDVLVNNAGFAFIGGVEDTSEEEVRSQKEVNVYAPLRVVRTILPQMRQRRAGEVVLISSDAGFIARPGRGTYSASKFAIEAIHESLSHEVQKFGIRVLIVAPGAFGTSFASRIVILSKYQKSGGYSEDYQGTSVQQMVDMSVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHR7</accession>
    <name>A0A9W9XHR7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VanZ-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_001948</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793582.1">
        <property type="nucleotide sequence ID" value="XM_056931551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHR7"/>
    <dbReference type="GeneID" id="81621800"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037970">
        <property type="entry name" value="vanZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040995964" description="VanZ-like domain-containing protein" evidence="3">
        <location>
            <begin position="31"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5493202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="23811" checksum="9D22696C50B9B8DA" modified="2023-11-08" version="1">MRIRYPFAGAFAFLLILAAYIGLLPHSTSSSIPSNLQPNDKFLHLVTFFLLTAAFYWVVDTSRRRTLHITLLVCTLFLGLGSEIVQGFLPNGRDFDPFDILANVVGSLGAVGLCSWYHRRMLERRRQSRFGLMEGGEDEDVELGTGLGRSRDEEGLGPQESGVTNLEQEVDNWDENAIDNWDTEEGPEPSDHGPAPPSYTETHSAVEIPAKRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHX1</accession>
    <name>A0A9W9XHX1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc transporter ZIP13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002069</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793703.1">
        <property type="nucleotide sequence ID" value="XM_056931672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHX1"/>
    <dbReference type="GeneID" id="81621921"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF16">
        <property type="entry name" value="ZINC TRANSPORTER ZIP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040995454" evidence="7">
        <location>
            <begin position="31"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5493323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="411" mass="43110" checksum="74F3F983F1BDEF98" modified="2023-11-08" version="1">MAPRLMNSSRTGLALLAGCIFFSAVVAASAHVDDLSVGEIEEQLQRCPLVEALNEHKRASAPETASFTARIFAVLFPGSPAVNALLATLYISGPPNFLLALCPPNIDPSSLSVMVAFAVGGLLGDTLFHLLPEIFLGEASPEHVSFVMVEPNKNPLLGLGIMVGFFTFVAMDKTLRIATGGEGGHDHTHGDSHASNDHNASTTSAQLTGTTNSELKQRKSPKSETELSVQDSSAEKDINPSVKLGGYLNLIADFTHNITDGLALSSSFYASPTIGATTTVAVFFHEIPHEVGDFALLIQSGFSKRKAMGAQFVTAIGAFLGTFIGIAVQEFGGNSAVSQAAAGAGIWGTSLQWGDMLLPFTAGTFLYVGTVAVIPELLETGKDKGAEVRKTLTQFLAVAVGAGIMLLISWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHX3</accession>
    <name>A0A9W9XHX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit KXD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">KxDL homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_001960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KXD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793594.1">
        <property type="nucleotide sequence ID" value="XM_056931563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHX3"/>
    <dbReference type="GeneID" id="81621812"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051390">
        <property type="entry name" value="BLOC-1_subunit_KXD1"/>
    </dbReference>
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        <property type="entry name" value="KxDL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KxDL"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="KxDL" evidence="9">
        <location>
            <begin position="85"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5493214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="182" mass="20141" checksum="8BA6BD177873C1BB" modified="2023-11-08" version="1">MATQRHLYQPSAYHTSLPSKTPVSTHLYPISRVPGSPPEYSDASTTGGSRSSGGLTFSSAGRSVDYDSSSASYSGVDMVDILSDRMQTAFDPTSLDKGLAKQAQTSGHLNAKQRELLELQALAQRRLKGVRSNFAEGVKTARETKRDLEWTQKRVSALKSKAEKSHPDEYRRSAKKYTYDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIN7</accession>
    <name>A0A9W9XIN7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation machinery-associated protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5493250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09072">
        <property type="entry name" value="TMA7"/>
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    </dbReference>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5493250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="69" mass="7351" checksum="6C51B4F7266F23A7" modified="2023-11-08" version="1">MGGSSREGGKAKPLKAPKKEKKDLDEDDLAFKEKQRADAAAKKALLESTKGKKGPLNTGQQGIKKSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLH4</accession>
    <name>A0A9W9XLH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA/RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794177.1">
        <property type="nucleotide sequence ID" value="XM_056929884.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81620133"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="77675" checksum="32BF4A7BE5956A13" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLJ6</accession>
    <name>A0A9W9XLJ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794116.1">
        <property type="nucleotide sequence ID" value="XM_056929823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLJ6"/>
    <dbReference type="GeneID" id="81620072"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF286">
        <property type="entry name" value="5-PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="462" mass="51043" checksum="F279E19CCD8F049F" modified="2023-11-08" version="1">MEELSIYIVTSNCARNIIDVDLFAAHLFDVLPASSPAPDLIVLSLQELAPIAYSFLGGSYLQPYFDAFVKLVKQATAKRWNESYTNVVKDHIGMTALLVFARADIANRLNEIDTAHVGFGFQEMGNKGAIGAHLKYASAGQPSLAADLTFVAAHLAPMENGLLQRNRDWQSIVERLVFTHGQDSPHNPSKNGHTADESTSLLRDNDHATPEGPEKSPHNLFAPNAYLFLAGDLNYRTSNISPLKDDHARFPKRGATPESPYHYSHLLKNDQLMQEMREGRTLHGLTEAPINFPPTYKFSNAAQQAARQALENGDSEAEWLWSTHRWPSWCDRILYLDDAAKVRQAGDSLEALTIKPAVYDALPLLPHSDHRPVALCVSVPLRRLAAPANRDLTTDGPSVSSSTQTEGPFQIDPQWLSRRDAARRKEIVVGVLAYLGMTWEGNGMVLASFAGLIGAWMVLRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLZ8</accession>
    <name>A0A9W9XLZ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794430.1">
        <property type="nucleotide sequence ID" value="XM_056930137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLZ8"/>
    <dbReference type="GeneID" id="81620386"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="108" mass="11722" checksum="B7789EEF384BC42C" modified="2023-11-08" version="1">MVSTTENHPLVPETMQTRKSLSDADGHPAAMQSHRLDDTEMNLIVDDVAPSSQSTCAELAHDHALEDLHKMTDHDFAADGGGLGQKRPGYRIGYLDHGTQCELGRPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM43</accession>
    <name>A0A9W9XM43_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794570.1">
        <property type="nucleotide sequence ID" value="XM_056930277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XM43"/>
    <dbReference type="GeneID" id="81620526"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="17"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="280" mass="31686" checksum="1D2A5B9F08B3B658" modified="2023-11-08" version="1">MGSRTAESAFSRAFALPEIILAIMHQMDMRTLINCQRVSHNWATLIRHSASLQRALYFLPREAPSRKPVRVYNELLAEIFPSCFPAPGAPDQELELTSITFVDDPETLKVFLRPEASWRRMLTTQPPIHTVGTFVAGTTESIGLRWQQSKAEPLPDGLRMGVLFETLLSVSEWTWQNETTWIARGGTQPVNATEPFVQPSDFMRVDDMNADWERTIRDLDLVIVTFGHADDSAPEDSDLELLHGADAMVWRKLRAAYKELGLTVGGLVMEKYNEGTETWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN16</accession>
    <name>A0A9W9XN16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U1 snRNP-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_001029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794926.1">
        <property type="nucleotide sequence ID" value="XM_056930633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN16"/>
    <dbReference type="GeneID" id="81620882"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="280" mass="31014" checksum="CE4671A881BF2188" modified="2023-11-08" version="1" fragment="single">MAAEQRKLLEQLMGADQLIGGGAQGRNSQLAITDPKVCRSYLVGTCPHDLFTNTKQDLGPCPKVHSEGLKTEYETASPAEKAKWGFEFDYMRDMQKYIDDCDRRIDTAQRRLEKTPDEIRQTNNLLKQIADLNNTINTGLLEVSVLGETGSVAMALGEMHKVRTAKQQKDNAERDLKLLQDTSGPSGHQKLQVCDVCGAYLSRLDNDRRLADHFFGKMHMGYSDMRKGYKKLSAELKGRAPPVRHHEEEDPYSAGGRSGGRGPRYGGGGGGGGFRRRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJ49</accession>
    <name>A0A9X0BJ49_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cation efflux protein cytoplasmic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_009513</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785603.1">
        <property type="nucleotide sequence ID" value="XM_056939108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJ49"/>
    <dbReference type="GeneID" id="81629358"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000004">
        <property type="entry name" value="Cation diffusion facilitator 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF4">
        <property type="entry name" value="CDF DIVALENT METAL CATION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="280"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="9">
        <location>
            <begin position="494"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5466557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="63863" checksum="5B00E9DD2535C11A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJC3</accession>
    <name>A0A9X0BJC3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785904.1">
        <property type="nucleotide sequence ID" value="XM_056938527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJC3"/>
    <dbReference type="GeneID" id="81628777"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5469314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="221" mass="24224" checksum="D3BF56AFE307D807" modified="2023-11-08" version="1">MRSAPGGVRLERQGVLEVWGIEYADAAVQYMSAPIFSYNACPSGGCDADRPAVPRSDLMGCCQIAPPAWRNASDLLRRAKTRREREENKMPAALRNPTFRRHLIRTRAVSPAHIQRHAPDDSVLADLILIHTVWKTRNLLSAGGLLPRFEASQRPLSSDENSCAYDYEAAPQAATYNFVQILYGHYALIAVTASAMCNVHQLHTHALGQLGNDASDEAGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJF2</accession>
    <name>A0A9X0BJF2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_008946</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785918.1">
        <property type="nucleotide sequence ID" value="XM_056938541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJF2"/>
    <dbReference type="GeneID" id="81628791"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="12"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5469328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="375" mass="40162" checksum="BC5E7B44702D47CE" modified="2023-11-08" version="1">MQNQAAYQPSQKAPSLQVRDAPSPSSPSAGQLVIRNRAVAINPIDSLIQSRGNMMFTHLKYPFVLGYDMAGEVMQTGPGVTHVKPGDRVLAFSRGPEKDTNDPAQSAFQKYAIVNEDFVCRIPETVDFAHAATLPLAVMTAAAALYDSSQLGLKLPQLVSSSRKKSASTSKGTVLIWGGSTSVGCNAIQLAVASGYEVFTTASPKNHDLVCRLGATRVWDYKSPSVVDDIVAELKRRILVGAVSIGSGAAEKCIQIVGRCEGNRKIAMVTYPVPDKDPENFAVLRTVAIFLFSLVSYKIRGLLGGFKSNLVVISPILDNGIARTVMTEYLPEALAEGSFVCAPEPEIVGEGLEYIQEAFVRLRGGVSAKKLVVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BJG7</accession>
    <name>A0A9X0BJG7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Rad50/SbcC-type AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_009067</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786039.1">
        <property type="nucleotide sequence ID" value="XM_056938662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BJG7"/>
    <dbReference type="GeneID" id="81628912"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="14">
        <location>
            <begin position="109"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="470"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="273"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="721"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="827"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5469449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1138" mass="129217" checksum="3022D26BCB4C4DE8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BLM5</accession>
    <name>A0A9X0BLM5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_008803</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786406.1">
        <property type="nucleotide sequence ID" value="XM_056938398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BLM5"/>
    <dbReference type="GeneID" id="81628648"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5471860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="173" mass="19510" checksum="C0DE43BAE4E77AEA" modified="2023-11-08" version="1">MTPVRQYSVLSTLQRLKYLPASIFLPRRPVLVAPSFSLFLASETGRKVRKPLLVRTISTREEKMTLDDLGMEQLFFYTSGRWLWDEEQQLRDRYKALNVAQLQTLASQATGSDGCASITKLAEGGFNKVFRLQMNDGKAILARIPNPDAGPPFYTTASEVATMEFVSLFPQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BN77</accession>
    <name>A0A9X0BN77_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787159.1">
        <property type="nucleotide sequence ID" value="XM_056937294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BN77"/>
    <dbReference type="GeneID" id="81627543"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="720" mass="82265" checksum="79168529415D4629" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNH9</accession>
    <name>A0A9X0BNH9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NUDIX domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_007846</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787312.1">
        <property type="nucleotide sequence ID" value="XM_056937447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNH9"/>
    <dbReference type="GeneID" id="81627696"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF24">
        <property type="entry name" value="PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5475559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="243" mass="27347" checksum="D013A626A9A66FF3" modified="2023-11-08" version="1">MISSLSPTGKADTLSETAFETARREACEEIGLPDINQTLPPPFAVEHLCELPANLAKTELVVRPCVALLHSFDPATGMNADPETELIPRLDAREVAAVFTARFDDFLRIKNSQGRGEGDWYKGSWSLWHNSNWRMHQFFVSNADHAVRPRSPGNQTQNAAVETLSRQEESGQVPHYRVFGMTARMLVDAARVAYARDPGFEHNSHFGDEEMISKLRRLGRLSEKRRPGEELTRETMERAAKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNL2</accession>
    <name>A0A9X0BNL2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787090.1">
        <property type="nucleotide sequence ID" value="XM_056937998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNL2"/>
    <dbReference type="GeneID" id="81628248"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="783"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5475332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1006" mass="111440" checksum="68A2EB51510BFA73" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNZ9</accession>
    <name>A0A9X0BNZ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_007120</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ATG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5476976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787520.1">
        <property type="nucleotide sequence ID" value="XM_056936721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNZ9"/>
    <dbReference type="SMR" id="A0A9X0BNZ9"/>
    <dbReference type="GeneID" id="81626970"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043936">
        <property type="term" value="P:asexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16128">
        <property type="entry name" value="Ubl_ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000010">
        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="11">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5476976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="118" mass="13748" checksum="8C78807255E14793" modified="2023-11-08" version="1">MRSKFKDEHPFEKRKAEAERIRQKYADRIPVICEKVEKSDIATIDKKKYLVPADLTVGQFVYVIRKRIKLSPEKAIFIFVDEVLPPTAALMSSIYEEHKDEDGFLYITYSGENTFGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BP19</accession>
    <name>A0A9X0BP19_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788058.1">
        <property type="nucleotide sequence ID" value="XM_056937259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BP19"/>
    <dbReference type="GeneID" id="81627508"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="293" mass="32105" checksum="1CDCEAE38187EB77" modified="2023-11-08" version="1">MTKKPALNVLTRLPAQVHIRAHPPPRNLAESKQIFAALQRYGEIISFRNLKVGGPSPCAIAPYDILNDTERERPLLAIFDSNEAAERAIAASPLTVDLPPRTSPTFPRNPYATIPGPPRSKESSKASSSPPSPSVSASSPTPTSTQPAPSITCTIETSRHNYERATRRNPFYSMFNIDKSSPIYKDMRSEETATPLPELADVLQRTKKPTFATQRYGTRVHAQRLGADSLMKLWKKGFAERQGKGKAERTARVAQSENIGDEDGDGGHMTESGEPGAQLDGSVTKKFDTHERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BP40</accession>
    <name>A0A9X0BP40_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787791.1">
        <property type="nucleotide sequence ID" value="XM_056936992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BP40"/>
    <dbReference type="GeneID" id="81627241"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="693" mass="75514" checksum="7AA858BA533DCC79" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSM8</accession>
    <name>A0A9X0BSM8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_006680</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788216.1">
        <property type="nucleotide sequence ID" value="XM_056936281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSM8"/>
    <dbReference type="GeneID" id="81626530"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="121"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5480786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="276" mass="31262" checksum="B1ABB9D48CDB542E" modified="2023-11-08" version="1">MPATKEGRVTKSKRAQRSSGSPARRVSSVAKSLPLVERTNALAIGDFISQYVPSLDVMRLQGKGADHAESTADKDSRERENNIQLDVYSTATLSGEDLEACLDLVELTSREDYSTSSAGWSRSKKRKEMKLPEMKYLILRNTTEKAELSGQRQCEPPGENKLENEEDTKSKILGFLSCMVTYEDGREVMYCYEIHLSHEARGRGLGGMLMIQMEEIGRRIGLEKCMLTVFRSNTRAREFYEKGGYQVDEYSPQPRRLRNGTIKEADYLILSKRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSN5</accession>
    <name>A0A9X0BSN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788382.1">
        <property type="nucleotide sequence ID" value="XM_056936447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSN5"/>
    <dbReference type="GeneID" id="81626696"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5480952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="416" mass="46704" checksum="BAB1CFE3FD2DD11E" modified="2023-11-08" version="1">MGSLRGADDVETIGEQFESRLFRKHYLIKGLLWAVLLYGSLVLSIIAYCNPALLPFNPLSYVFNIEVSPFFAFSQGSEYFPKPHGVRIVALVPFHYHERTAILDCYLQNNLVQNRGLLDQVVFIPQTDDAFSLQWLDALVQKTPEYAISVGEDDMDWKFTQANVLYVRIDGDVVFLEDHTIPTIVKTRLEDPDSLMISANVMSEGALSSLHSHHGVALPYLPELDEADQDPQTNGQSHSDWHASNLPLWNGPAAFVIEKEFRPPFQGHRWLPVAEEGLDRDPIASAMRRETGPSLQEWTVSAQHHYSFLDHLESNTLSRYKFPLWKNPPEAVSSTLGCFWGKDAAALRELYGQQTASEGLSTIWTASDGSHPNITIDGKGLASHYSAEMAVAGLDSTDLLERYHAYAQENVCRPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSV6</accession>
    <name>A0A9X0BSV6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Translin-associated protein X</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_007041</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788577.1">
        <property type="nucleotide sequence ID" value="XM_056936642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSV6"/>
    <dbReference type="GeneID" id="81626891"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5481147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="29344" checksum="1D0ECEC08791F8DD" modified="2023-11-08" version="1">MGTKRSWEGQTVVNMSASESTNPTLAIFGNFRDELDEHHDRRERIIKASRDITALSKKIIFALQRVRAIKQPIPQNIIKENDARVEQIYKHFASVTADLVGIKSWRYQRQISGGIQEFIEAISFDHYLRTETLITHAEVVERLPGILVTEEDYLMGIFDLTGEMMRFAVTALSSGKVTPTDAAKAGVLVDLRAIRARCEALSVSGRHRASMYKDLAKKKEVMQNSVEKVERAAYGILVRGSERPSGWTPDLSGPAMEVETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BTA3</accession>
    <name>A0A9X0BTA3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ribosome maturation protein SDO1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_006471</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788997.1">
        <property type="nucleotide sequence ID" value="XM_056936073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BTA3"/>
    <dbReference type="GeneID" id="81626322"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="10">
        <location>
            <begin position="110"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="11">
        <location>
            <begin position="270"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="142"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="222"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5483025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="333" mass="36352" checksum="C2503C29A9B7A8A2" modified="2023-11-08" version="1">MPINQPSNQIKFTNVSIVRLKKGKKRFELACYKNKLLEYRSGAEKDLDNVLQVPTVFLSVSKAQTAPAAELSKAFGADTPRDEILQEILRKGEVQVGERERKEVLERVEKEVLDIVSGRLVDPNTKRVYTSGMISKALDQLLSASGQQQQQQQQQNGEANGAGDELPKKPMWTGVSSNRSAKSQALDAMKALIAWQPIPVMRARMRLRVTCPVSLLKQSVKAAPVANAVREEKPSGKGGKKGGKGNKKSKRDDSEDEAGASGSEAALKASGTVKDKILTYIEAVESQETSGDEWEVVGFAEPGAFKGLNDFIGTETRGRGRVEVLDMSVTHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BU84</accession>
    <name>A0A9X0BU84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789315.1">
        <property type="nucleotide sequence ID" value="XM_056935443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BU84"/>
    <dbReference type="GeneID" id="81625692"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048273">
        <property type="entry name" value="Luciferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040841">
        <property type="entry name" value="Luciferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17648">
        <property type="entry name" value="Luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase" evidence="1">
        <location>
            <begin position="187"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5484045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="277" mass="30771" checksum="B1DEFB1BAB868174" modified="2023-11-08" version="1">MLDSVISVLRQIPCPRSQQDRLNVALGTVAVIGSALLLPSAYRDYRIFRGYGDGGVPNNILGWMTVRALFQPFGREMVSTEVYVQRIDATDGHGQGHDGYLTLSEEQLSARRRDGRPQIGPHVVPQRQLTQIPDEDVMEKFHSRFDSFGLRNHHLVKFQQSNLEGHAQALFVANHLPITDLATCMQGEIAHIHSGHDYSVHAVLAPADCKKVIDAGWGQRHAFSGTSAMTFLSLGTIPNIPSEYLLIYAPRNDAEVDIVMEIISASVKFMTGREDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUX9</accession>
    <name>A0A9X0BUX9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_005073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789869.1">
        <property type="nucleotide sequence ID" value="XM_056934675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUX9"/>
    <dbReference type="GeneID" id="81624924"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5485085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="673" mass="74994" checksum="A124F09BC37E5C0B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BV38</accession>
    <name>A0A9X0BV38_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_005223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790019.1">
        <property type="nucleotide sequence ID" value="XM_056934825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BV38"/>
    <dbReference type="GeneID" id="81625074"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008318">
        <property type="term" value="F:protein prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF3">
        <property type="entry name" value="PROTEIN PRENYLTRANSFERASE ALPHA SUBUNIT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5485235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="357" mass="40608" checksum="67F3B72ED812D4F4" modified="2023-11-08" version="1">MTSPVDAFEQLVDLFDHRGDQVLEIEIIPPSLGSSFLKDGCAMGISKKALIQAYMVARRVFFETCTSMSSNELVADLLREQSSSVANKEKFVTEIMLLFDCEHLTAANWRKCRILAALAQHEGPSNQTSQQTRMLKTELTLLQSYQCSPLPRHTKSPTLWSHRLWTLEHLINLVELSVDTLLDLQRHELEVVLRAAELHPRNYYAFTYARHLRSLLVRTAATITTESISCWELRLAKALLSPVLDWCLAHPRDISGWSFGLHVLGHCEDRQSHEEAVKRVLQFALDVGWEGESLWTFVDQAVRRFDLEDTVVNECLPLPRTLERPGAVAEDQTAQASWRAWLSRAQANWAACKADRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXI5</accession>
    <name>A0A9X0BXI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_003721</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790864.1">
        <property type="nucleotide sequence ID" value="XM_056933323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXI5"/>
    <dbReference type="GeneID" id="81623572"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="6">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="175"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="5">
        <location>
            <begin position="306"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5488831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="66905" checksum="DF467AB73601E69F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXK0</accession>
    <name>A0A9X0BXK0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-splicing endonuclease subunit Sen34</fullName>
            <ecNumber evidence="5">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_003766</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="5"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790909.1">
        <property type="nucleotide sequence ID" value="XM_056933368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXK0"/>
    <dbReference type="GeneID" id="81623617"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000008">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016690">
        <property type="entry name" value="TSEN34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017250">
        <property type="entry name" value="tRNA_splic_SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="9">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="8">
        <location>
            <begin position="220"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00059865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5488876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="320" mass="35113" checksum="DC276F5F59748D4C" modified="2023-11-08" version="1">MESAPSLPISISYVSGRYLLFSIDVVTYLRREHNICGVLIGTLPQIPQQNVFLGLPLELMPEEARLLVDKGVACIVDEVKAHDGMRSLLEEDRRAYLRDLETQGQLAARILADRKEQQRVQSLKEIDEKRAKGLAAKAAKAAQAAAEIQATETCRSSTEAEESASLFAPVDEKTSTSRTTGTTTPAPLAVMAVTPTTSYPPLPEPAAAEHRLPRPDVPLSYPLFAHLHSLGYFLSPGLRFGCQYVAYPGDPLRFHSHFIVVSAEWDEDIDLMNIVNGGRLGTGVKKGFLLGGPQKRRDEVESEADRVGTVRTFSIEWAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY13</accession>
    <name>A0A9X0BY13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_004276</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791419.1">
        <property type="nucleotide sequence ID" value="XM_056933878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BY13"/>
    <dbReference type="GeneID" id="81624127"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5489386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="23731" checksum="C9509B8A571D0FF3" modified="2023-11-08" version="1">MAQPNPYLLACDNPSGLLELLRANPAIASTQDEHGYSLLHAAASYGHTDLLRALVQEFGVDVNLLDEDGETCLFVAETPKVARCLVEELGVNCNKTNDDGYKAHEKMEADDEFPQVVAYLRDVVGAPAPSTDSAEGPLNAPPPIPENMKVNIGTMSEQEANAGGMEVDPEFKRRIDELAAREDFNSQATQDELRALVMDAISGSSIETADRETRRRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY17</accession>
    <name>A0A9X0BY17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">5'-AMP-activated protein kinase subunit gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_003949</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791092.1">
        <property type="nucleotide sequence ID" value="XM_056933551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BY17"/>
    <dbReference type="GeneID" id="81623800"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="154"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="228"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="302"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5489059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="361" mass="40489" checksum="F89B34C066F700CD" modified="2023-11-08" version="1">MTKAEDTRPHLAGPSNFTGHAPFVQPSSYLRPPMSSQPERPIDVEERQGLRAIRNFLKVRTSYDVLPLSFRLIIFDTGLSVKESLNILIQNGKSTRIVSAPLWDSKASKFAGLLTTSDYINVIQYYFQNPAALDQIDQFRLDSLREVEKALGVAPPETISIDPERPLYEACRRMLESRARRIPLVTNDSQTDRSHVLSVITQYRILKFVAVNVGDTQKLRRPLGELLLGTYNNIATASMDTPVIDVIHILVERSISSVPILNSEGVVYNVFEAVDVIALIRGGVYDDLGLTVGEVLKKRSPEFPGIYTCSLNDGLDTIFDTIRKSRVHRLVVVDEHFKLKGVLTLSDILHYILLEGETDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY33</accession>
    <name>A0A9X0BY33_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cullin-4A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_004336</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791479.1">
        <property type="nucleotide sequence ID" value="XM_056933938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BY33"/>
    <dbReference type="GeneID" id="81624187"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000061">
        <property type="entry name" value="Related to cullulin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000036">
        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000011">
        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="464"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="364"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5489446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="845" mass="97070" checksum="4A81AC0ED82992CA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BY45</accession>
    <name>A0A9X0BY45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791448.1">
        <property type="nucleotide sequence ID" value="XM_056933907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BY45"/>
    <dbReference type="GeneID" id="81624156"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="70"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="349" mass="39894" checksum="ACD379C63E81EB03" modified="2023-11-08" version="1">MASQFETGVFQKFHFIEKERVIIRDQIYGEHTITEPVLIELLHSPELSRLKGIRQSGVTALLGFGPKVTRLEHSVGAFLLTRKVGASVEEQIAALLHDISHTSLSHVVDYALSKAGEESYHEVYKSRYLETTQLPEILIRHGFSDLKALDEEHFPLVEQPSPHLCADRLDYSLRDSLAFGKLSLEKVRRVFDSLRAVPNSSAPNRLLVLDNPQLALALSRAYQATDRDVWSNRSHANIYRRTGRIIKELVESGRVDERALWTLSDVEFWSLLRRQATPQLLSELDRLENEGLPDENELRLPQQTKIRTLDPDICLADSKTKEPVPLSVMLPEWGAERQQYIDERESTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYG1</accession>
    <name>A0A9X0BYG1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_004650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791793.1">
        <property type="nucleotide sequence ID" value="XM_056934252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYG1"/>
    <dbReference type="GeneID" id="81624501"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5489760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="388" mass="43174" checksum="85747C1CBF015B40" modified="2023-11-08" version="1">MEDKSDLGGQNCGHCKASRRGRSRRWLSKLKANLSPRVVGKRKAVRNNVLLFIVFVIIVGGIIALVWFSLVLALIHRLSPSTPSNGLQRIVQSWKTPSDSISLLSPWPHDFSQGIVPVSCHSHNDYWLSVPLFEAIAAGCTGVEADVWLRENKTLLVGHGESSLTSDRTLQSLYIEPLSTILLNLNGNSSSNDVTSPVGIFDIDTTVTLTLLIDIKSDAITTWPVILDQLSPLISGGWVSHWNGTTRKLVHGPITVVGTGNTLFQQVTAEHDRYVFFDAPLHEISQNSSYSSENSYYASVSVKKAVGMVWTWGPTQSQKRTMQEMIDAATERGLVSRFWSIPSWPVNLRMQMWQFLVESRVGMLNVDNVVEATRWNWDWCTVAGLVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYM0</accession>
    <name>A0A9X0BYM0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">linoleate 8R-lipoxygenase</fullName>
            <ecNumber evidence="3">1.13.11.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_004594</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(9Z,12Z)-octadecadienoate + O2 = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate</text>
            <dbReference type="Rhea" id="RHEA:25395"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:58659"/>
            <dbReference type="EC" id="1.13.11.60"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.60" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791737.1">
        <property type="nucleotide sequence ID" value="XM_056934196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYM0"/>
    <dbReference type="GeneID" id="81624445"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052878">
        <property type="term" value="F:linoleate 8R-lipoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20612">
        <property type="entry name" value="CYP_LDS-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000005">
        <property type="entry name" value="Fatty acid oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF37">
        <property type="entry name" value="PSI-PRODUCING OXYGENASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5 11" id="KW-0349">Heme</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5489704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1087" mass="122046" checksum="E1B189FA782AA093" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ14</accession>
    <name>A0A9X0BZ14_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792434.1">
        <property type="nucleotide sequence ID" value="XM_056932475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ14"/>
    <dbReference type="GeneID" id="81622724"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="61" mass="6801" checksum="55EACBBFCDFC0CD8" modified="2023-11-08" version="1">MSERKYGKGKAVTNAKCPQWSQIPIAHGAEDKSVKTEPKKKEVGQRSDNGDGLQSWVWTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ45</accession>
    <name>A0A9X0BZ45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_002962</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792524.1">
        <property type="nucleotide sequence ID" value="XM_056932565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ45"/>
    <dbReference type="GeneID" id="81622814"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="200"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="657"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="708"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5491395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="865" mass="95064" checksum="D06BEB6EC9C2E581" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZE6</accession>
    <name>A0A9X0BZE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_002649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792211.1">
        <property type="nucleotide sequence ID" value="XM_056932252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZE6"/>
    <dbReference type="GeneID" id="81622501"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF64">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040878497" evidence="6">
        <location>
            <begin position="23"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5491082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="591" mass="65745" checksum="123B20F1C613C27A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZI5</accession>
    <name>A0A9X0BZI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792839.1">
        <property type="nucleotide sequence ID" value="XM_056932880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZI5"/>
    <dbReference type="GeneID" id="81623129"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32697" checksum="A82D3CA15585CBB5" modified="2023-11-08" version="1">MSISERSGETEQSFTQDSNPTVGLMSLPPELQIAVFQSLDSLEDIACLSGTCKQLHGVLNAHIPLICETVAARTLPCYNEMRAVVAEQGLLATDHPITEMSLIAHFASMSHNMDKLITYYHTFWVNNSHNDPRISQQLSPTEQTRFIKAHYQLWAMMLVSQDQRAQKISELDLEQSILLSDFLCIFSPEIINDAAVQKLVRQVPRFGRVLQRAIRGHRNRQFALQLGVEYHPISWTPYQPPYRFAWWCDKQQDLLHRMLSGALFEQGGSAHHPIEIIDDLEDAQEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZJ1</accession>
    <name>A0A9X0BZJ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_002799</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792361.1">
        <property type="nucleotide sequence ID" value="XM_056932402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZJ1"/>
    <dbReference type="GeneID" id="81622651"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF4">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="676"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="727"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="753"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="778"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="815"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="8">
        <location>
            <begin position="116"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="8">
        <location>
            <begin position="179"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="9">
        <location>
            <begin position="691"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="7">
        <location>
            <begin position="840"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5491232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1112" mass="125265" checksum="6DD48A0E60B7BEA3" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZT5</accession>
    <name>A0A9X0BZT5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793138.1">
        <property type="nucleotide sequence ID" value="XM_056931107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZT5"/>
    <dbReference type="GeneID" id="81621356"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="330" mass="35995" checksum="AE009BE0EEC07A36" modified="2023-11-08" version="1">MPDEPRRIIIEKSSTVRRRYQRSNKRFKFSASQLRRIEREEELERRAQAIRDKEAKRRANKKRKAEKEAKDREERKRLGLPDPCAPKIPASQPLLSAFLGAKPAPTEQRSVTDSRSAGSEEEGLSEMANGFSGGDTEVDSDCFDDLDEVLLEQGLVLPGEDEQRDQCPRGGSLKADTLGDASPKTVSPQVGGESLLPVAHEDHDGDDHAKQRIDDDDDDDGDEFSDCSVFDDADIIQEADAIVAARMSQLKAINSLPVPSTSPSQTAAKAMMGPPALIEQAQSQALTTSIPSIPTSDSFCDDTADYLEDVFARGCGDSFSELVQLGSGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZX7</accession>
    <name>A0A9X0BZX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RTA1 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_003340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792901.1">
        <property type="nucleotide sequence ID" value="XM_056932942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZX7"/>
    <dbReference type="GeneID" id="81623191"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF15">
        <property type="entry name" value="LIPID TRANSPORTER ATNI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5491773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="38247" checksum="14E26BF702BE6EF2" modified="2023-11-08" version="1">MGWPTRCDLSSADAQYAYCANGPVAVFFSVLFGLTWIAHLVQAVMYRKKFCWVMVVGTLWECIGLVMRTYSTIDQTQANTASAGQLLVLLAPLWVNAFVYMIFGRMVYYYLPEKRVFGIRAESLAKVFIWLDVSSFIVQATGGIMDSDFSPEMNKIGLHIYTAGIAVQQLFIVIFCALIYAFHRRMREGAGDYSRGPHWHTLVIAMYGTLACITIRIVYRLIEFANTDTAGKSPLTVHEAPFYCLECVPMFAAMIIWNIWHPGRYLQGEESEFPKKIKVSRKDKKRQKQEAKDLKRQGRKRSSSRRGKRDSEYHLTSADEGTYEDAYPMHGRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C024</accession>
    <name>A0A9X0C024_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methionine aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_001295</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="11"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792929.1">
        <property type="nucleotide sequence ID" value="XM_056930898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C024"/>
    <dbReference type="GeneID" id="81621147"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000010">
        <property type="entry name" value="Methionine aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5492549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="395" mass="43671" checksum="B6B935FF36754AF6" modified="2023-11-08" version="1">MAAVATRKCNGVDCPNDAGTLQCPTCLKMGTDSFFCSQDCFKRSWSEHKNIHKKSNLLTNLFPPKVVSEPDPATGHFNPFPSFQYSGALRPVYPLSPKRTVPQSIPHPDYAKGGIPISEQKLWGQHKIKILNKEEQEGMRVVCRLAREVLDIAARALKPGVTTDYIDEVVHKACVERDSYPSPLNYMHFPKSVCTSVNETICHGIPDQRPLEDGDIVNIDVTLYHKGFHGDINETYYVGDKALANPEAVRVVETARECLEKSIELVKPGMLFRDPGNVIEKHAKSRDCSVVKTYCGHGINQLFHCAPNVPHYAKNKAVGTAKPGMCFTIEPMINIGTHRDRTWPDDWTSTTADGSLSAQFEHTMLVTEDGVEVLTARLSDSPGGPVPMPSTENGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0F1</accession>
    <name>A0A9X0C0F1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deacetylase complex subunit Sds3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_001655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793289.1">
        <property type="nucleotide sequence ID" value="XM_056931258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0F1"/>
    <dbReference type="GeneID" id="81621507"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="189"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5492909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="51426" checksum="C0D59E5DF3885CED" modified="2023-11-08" version="1">MAYSPGPQSPGAGPAYMATRNRSASPPGASGMPSKRDKRRTALQERLHDLTATFSQNRDAQFRQQLHSLQCDMTLINNADPYQTGPLPDSSADIARLIEETFVQEINNVKEQKDADLAQIMNRHQNSLERHRREYDFRVHFAKEEFNQLSGTLRERLMQSISSKRSRLMREKEQLDIADTNALLLHPNQFSITNPASPGGSMLNKRKRKAPEEEPGSPAREAGGTTPAERSKAYVEKQSAPTYSIQSLFTDKELSAHSNQAHVATVHFFSTSKRPEQGSGAVTNGNNTETEDTLDGTVHEENGTPSATDMMRTASQNFHITRSTRGTAAHSALSALADLADKNATRPALPYHVLSNYHARPNGNAPPLTSLLSEEVDDDLSRVDRLHNSKAGAWIDASLVDLVVAPLPSEPVDGRPPNPDRFTSLHPDFPAVVGMQLQPVRSNPGAEVFPAIAMERERSTKRSRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C227</accession>
    <name>A0A9X0C227_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">PQ loop repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_000319</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the laat-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794216.1">
        <property type="nucleotide sequence ID" value="XM_056929923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C227"/>
    <dbReference type="GeneID" id="81620172"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000011">
        <property type="entry name" value="PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF35">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER YPQ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="104"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5495203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="41538" checksum="D49E10314F4E2E1A" modified="2023-11-08" version="1">MLPPQAANLSIEALSGICGSISIACWVVVFSPQIIENFRRGSADGLSLLFLIVWLAGDVFNILGAVLQGVLPTMIILAVYYTLADIVLLGQCFYYRGFNIRDELSSSSSPDSNSVTGDTSESSEERDSDAVPTERSSLLPSSSGHARASESTEEAHPTSSSTAKHIRSSVSPNRDVAHHHVDGTHLSPATPFVDPSSEHARYQRRRRRISTIQSILFNMTAIALVCAAGILGWYVSPGSKKSKAEPEPLTLDPLGQAFGYLCAVFYLGSRIPQLLLNYRRKSTDGVSLLFFLFACIGNLTYVLSIMAYSPICQGTTAGANDVDELSHRHRPQCRPGEAAALYGQYVLVNLSWLVGSFGTLVLDMAIFVQFFLYRDAKSLDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2B9</accession>
    <name>A0A9X0C2B9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_000020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793917.1">
        <property type="nucleotide sequence ID" value="XM_056929624.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81619873"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.790">
        <property type="entry name" value="RNA-dependent RNA polymerase, slab domain, helical subdomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF14">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="459"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5494904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1323" mass="150644" checksum="14EDF5DA4ADC9FCB" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2R9</accession>
    <name>A0A9X0C2R9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794458.1">
        <property type="nucleotide sequence ID" value="XM_056930165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2R9"/>
    <dbReference type="GeneID" id="81620414"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36459:SF1">
        <property type="entry name" value="FATTY ACID DESATURASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36459">
        <property type="entry name" value="ORF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="128"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="419" mass="49407" checksum="BD22DED13D7FCE47" modified="2023-11-08" version="1">MDPTTYVDPELTIADHLVLDTLVDKSLATAKTTTAGAQRPSDEDVAQKLQDMNDASHPDFDPTIFQFWDSPVLQAKLPVALQQYVLQPYRQWAQGVVRFPTDVVMLTHLLLYFTTIVPSGIFLYYRFSWIHGILHWLMQLWYCGAFTLMKHQHIHMNGVLAPRYWLFDTLFPYLLDPMLGHTWNSYYYHHIKHHHVEGNGEQDLSTTMFYDRDNGYDFACYVGRFIFFIWMELPLYFWRKGQAKYAAKAAFWELGNYIAIYMLYHYVNARATVFVLILPLTVMRCGLMVGNWGQHAFVDPIDPDSDYRSSITLIDVPSNRYSFNDGYHTSHHLNPRRHWRDHPVAFVKGKDRYAEERALVFRNVDYIFITVHLLRKNYMHLAKCLIPIGDQVHMTLEQRAEMLRSRTRKFPRDYGKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2V7</accession>
    <name>A0A9X0C2V7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Elongation factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_000590</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794487.1">
        <property type="nucleotide sequence ID" value="XM_056930194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2V7"/>
    <dbReference type="GeneID" id="81620443"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000001">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040533">
        <property type="entry name" value="EF3_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047036">
        <property type="entry name" value="EF3_4HB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF5">
        <property type="entry name" value="ELONGATION FACTOR 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17947">
        <property type="entry name" value="4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 18" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <feature type="repeat" description="HEAT" evidence="15">
        <location>
            <begin position="188"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="448"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="692"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1000"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1041"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1041"/>
            <end position="1056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5495474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1068" mass="117979" checksum="BCFDC9F329091E07" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C3F9</accession>
    <name>A0A9X0C3F9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_001205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795102.1">
        <property type="nucleotide sequence ID" value="XM_056930809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C3F9"/>
    <dbReference type="GeneID" id="81621058"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5496089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="167" mass="19597" checksum="7344F7AB8DB3C0EB" modified="2023-11-08" version="1">MTDNGEMEETPFGLMSLYDLLTPEIPELAYTPTKVDIREARSLPCQFRPMEIFPSPTIMDQVDYNPGRVFPIPHEPLHLLNKKVLDDSLEWFYQVIVKGTVMAKGNNYKHLHWEKAVSGNLVWRLKFVDCVLMTSKPQNKKNWESLYLTQTQKMIKTHHDSERNLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKB7</accession>
    <name>A0A9W9WKB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear condensin complex subunit 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_009565</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785655.1">
        <property type="nucleotide sequence ID" value="XM_056939160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKB7"/>
    <dbReference type="GeneID" id="81629410"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="9">
        <location>
            <begin position="629"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="584"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1047"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="594"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1133"/>
            <end position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5466609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1147" mass="126882" checksum="565B4ECD5C99134F" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKH0</accession>
    <name>A0A9W9WKH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Halotolerance protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_009442</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785759.1">
        <property type="nucleotide sequence ID" value="XM_056939037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKH0"/>
    <dbReference type="GeneID" id="81629287"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000183">
        <property type="entry name" value="Serine/threonine-protein kinase hal4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF558">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="256"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5466713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="541" mass="60115" checksum="0D1D21B7CD93DFCC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKJ1</accession>
    <name>A0A9W9WKJ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_009380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785697.1">
        <property type="nucleotide sequence ID" value="XM_056938975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKJ1"/>
    <dbReference type="GeneID" id="81629225"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040795212" evidence="3">
        <location>
            <begin position="20"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="137"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5466651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1114" mass="116238" checksum="E62E49EAAF48B0D4" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKJ8</accession>
    <name>A0A9W9WKJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Myosin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_009483</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000018">
        <property type="protein sequence ID" value="KAJ5466754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785800.1">
        <property type="nucleotide sequence ID" value="XM_056939078.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81629328"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15480">
        <property type="entry name" value="fMyo2p_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01380">
        <property type="entry name" value="MYSc_Myo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046943">
        <property type="entry name" value="Fungal_Myo2/2A_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036103">
        <property type="entry name" value="MYSc_Myo5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50084">
        <property type="entry name" value="Myosin S1 fragment, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="13">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="74"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="11">
        <location>
            <begin position="1232"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="924"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="168"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5466754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1610" mass="183107" checksum="3EABB8E78A9FC874" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL79</accession>
    <name>A0A9W9WL79_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hpc2-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_009114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786086.1">
        <property type="nucleotide sequence ID" value="XM_056938709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL79"/>
    <dbReference type="GeneID" id="81628959"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="2">
        <location>
            <begin position="581"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5469496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="773" mass="80686" checksum="478C46ADAB107AE0" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLA1</accession>
    <name>A0A9W9WLA1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Dicer-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">N7539_008880</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785852.1">
        <property type="nucleotide sequence ID" value="XM_056938475.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81628725"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050688">
        <property type="term" value="P:regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001669">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000032">
        <property type="entry name" value="Dicer-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002480">
        <property type="entry name" value="Dicer-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
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    </dbReference>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
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    <sequence length="1365" mass="153781" checksum="DCA23C38121EDE09" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9W9WLB3_9EURO</name>
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    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <dbReference type="EMBL" id="KAJ5469589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="Proteomes" id="UP001148312"/>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLC3</accession>
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        </submittedName>
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            </authorList>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9W9WLH3_9EURO</name>
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        <recommendedName>
            <fullName evidence="7">NACHT domain-containing protein</fullName>
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        <name type="scientific">Penicillium diatomitis</name>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
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        <location>
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            <end position="563"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="694"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5469660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="756" mass="85032" checksum="F91F0628397E0733" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLS6</accession>
    <name>A0A9W9WLS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_009091</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786063.1">
        <property type="nucleotide sequence ID" value="XM_056938686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WLS6"/>
    <dbReference type="GeneID" id="81628936"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF130">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="99"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5469473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="488" mass="52603" checksum="7A4FD20F81B03CFB" modified="2023-11-08" version="1">MEPLEEKTRSPYLDHHDPGALEANLPAHEQHISGDDDGDSSTLDSAEVTSPRHHTHHAQNEIAHIPSNAESVLTRTLSVVRTRESGKDLGPPPDGGFTAWLQAALGHMIIFNTWGYINSFGVFQTYYTETLQRPPSDISWVGSIQIFLLFFIGTFSGRATDAGYFRFTITIGAVLEVFSIFMTSLCTQYWQLFLAQGLGQGIGCGLMFVPTLALISTYFQKRRGIAIGICASGSATGGLVFPAVVRRLLPSIGYAWTMRTLGFISLATLVPCLILLKQRLPPRTTGPVLELGAFRELPYLLFAVGMFLNFCGLYVGFYYVGSFSRDIIGATESISIDLLLVMNGVGVVGRLVPNLLADQVTGPLNLLIPFSAATAIVAYCWAAVSDLSGLWAFAAVYGIFAAGIQSLFPATLSTLTTDLKKIGVRMGMVMSVVGVAALVGSPIAGALVQRDKGGYLYAQMFAGSTMLAGMMTLVAARWVKVGMRVVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WQK6</accession>
    <name>A0A9W9WQK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_008607</name>
        <name evidence="2" type="ORF">N7539_008810</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPWDQ010000013">
        <property type="protein sequence ID" value="KAJ5472038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786584.1">
        <property type="nucleotide sequence ID" value="XM_056938202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WQK6"/>
    <dbReference type="GeneID" id="81628452"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5472038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="178" mass="19656" checksum="A8A2C51403BCBE26" modified="2023-11-08" version="1" fragment="single">AFVSGTFEILYREQTCREQVERLSHVKVAETLVLRVLLTLTIVIYISPPSTVIPWQVVFMAFVRTGNPACTIYLKLIALLVSALSLKIGVDGSTLSAARRELIGLLQLPSFAFLYQVSTFSNTIPSSSVHHRLMAGQVTAVEPNTFDSLIESHSSTFKAGCKNYERNRGGKPPAHFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTF9</accession>
    <name>A0A9W9WTF9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786937.1">
        <property type="nucleotide sequence ID" value="XM_056937845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTF9"/>
    <dbReference type="GeneID" id="81628095"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5475179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="112" mass="12251" checksum="530460D77EFF055E" modified="2023-11-08" version="1">MVRPGPPRVRERERGQASVNQKRRDDDASINFRRFKSGLRRPTFAPLDGGEEPPKQGRNGCAGTGHGLSKKKRLQGADLPGAIGFYSTIEDQRMLIGAEEQSSDATVVGKQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTJ8</accession>
    <name>A0A9W9WTJ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_008285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786977.1">
        <property type="nucleotide sequence ID" value="XM_056937885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTJ8"/>
    <dbReference type="GeneID" id="81628135"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF12">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="624"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5475219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="799" mass="89758" checksum="D2F4244BCD9C7F26" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTK5</accession>
    <name>A0A9W9WTK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_008320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787012.1">
        <property type="nucleotide sequence ID" value="XM_056937920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTK5"/>
    <dbReference type="GeneID" id="81628170"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000035">
        <property type="entry name" value="CCCH zinc finger protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000022">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156">
        <property type="entry name" value="CCCH ZINGC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="342"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="342"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="403"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="410"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5475254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="463" mass="50930" checksum="0A35E3A1C0346C3C" modified="2023-11-08" version="1">MTENEELLARIGQLAGQINRHKSQPAQSNQPSSHQSQHVSRHAHAHPGWAPYSRGRGRGRHPAPHRNRTLVLNNGTPGSAHSDASTPGPSSDNDAETRQPTTSNGWVAKRDRHMQLINSAVYEKEKVARAKALEESRKVKTQRRAQREQAKVLQYAQATRGNAMVSTMAQPGTAHQILVNDVPFKITHGGSKLVRVFSKTPLSYQHVERTDSLLLDDPNTANTTPKRVNVAGVTFVRSKNGNLHRLGAVASKKNPMTVKKRNELCKRFTSTGACYKGPSCPFVHDPNKVAICKDFLQTGECSAGMNCDLSHEPSPHRSPACVHFLRGRCSNPQCRYAHVRVNPGAPVCRDFATLGYCEKGVNCEERHVHECPDYANSGVCHKKRCPLPHVDRAGQIRKAAAAAAKAEASADNEDESDESSEEEDYAAIDSDDVDSDDFDDVSTELLEGVDSSEMAEQHDFIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV25</accession>
    <name>A0A9W9WV25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="9">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_007229</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787629.1">
        <property type="nucleotide sequence ID" value="XM_056936830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV25"/>
    <dbReference type="GeneID" id="81627079"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="531"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="552"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5477085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="562" mass="60760" checksum="90D218CBCB3309DC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVR3</accession>
    <name>A0A9W9WVR3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_007581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787981.1">
        <property type="nucleotide sequence ID" value="XM_056937182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVR3"/>
    <dbReference type="GeneID" id="81627431"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5477437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="65" mass="7389" checksum="FC46FAAAE40260B7" modified="2023-11-08" version="1">MPPVDGLEERQITFFGASGAEVIGLPSFLWPELRSESTELAPDEKNLVSKIRRPERLKAARKYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1J5</accession>
    <name>A0A9W9X1J5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788135.1">
        <property type="nucleotide sequence ID" value="XM_056936200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1J5"/>
    <dbReference type="GeneID" id="81626449"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23703">
        <property type="entry name" value="mS26_PET12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058940">
        <property type="entry name" value="mS26_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26163">
        <property type="entry name" value="mS26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5480705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="287" mass="32818" checksum="C5A02B45E357EAE4" modified="2023-11-08" version="1">MPILRSGRAATVQIRGFATSPSLRAGPESPHFVDVPRVVQAGPPTKPRVRGTLPVPRELFPARRTDKPHKAYLDAVTPLPSTERTVNPKSSDPEKQAFRLKMADVRRKNLREGLQTLYKRKQIAEQTMFNRSLDKQMRRERVLQQPEPEDERLTRSSIVSAMQAQPHKVLADPNRDEQLALSRARLEAKQAEKDAIRRDHLQSLYMNARTFIINEQQLAAEIDRVFPEGENEAWRNDHQHGENIWNLGTPPTVQSIVNETRKSETARWDVIQDRVKKLGEQITGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X255</accession>
    <name>A0A9W9X255_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_006661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788197.1">
        <property type="nucleotide sequence ID" value="XM_056936262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X255"/>
    <dbReference type="GeneID" id="81626511"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5480767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="303" mass="33831" checksum="456EA81933FBD3F3" modified="2023-11-08" version="1">MASLMKKLRRKRRLSSELDARWGDPSISYPNQGSWNQWDQPSGFVANASMGAASASFQSRERKDYMSTEPISTGDFGRSSDSHYHGSDVPMDQLHAISVIPKGYFNENIRHRVDRSRRAPPARGLGINGTLRDTNHSQKTLAGEEDSCEDGDEESDDDCCEEDHEDLAPGRFGQLRYDISVRSPLAADPRQQSPQENYDRAHDYHRPSKSPPLSVTQRMRRLSQQSAATDPISSTAGTASSRCTSYTAASSVSVPTLPPSTPRLAIKLDHALHDKRPIHRSRPKMDEAQSQQRMVPSYDELYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X266</accession>
    <name>A0A9W9X266_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-related protein RABA1b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788433.1">
        <property type="nucleotide sequence ID" value="XM_056936498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X266"/>
    <dbReference type="GeneID" id="81626747"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5481003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="315" mass="34282" checksum="EB547A62249CE892" modified="2023-11-08" version="1">MYDYLAKVILLGPSGAGKSCVLHRFVKNEWRVLSSQTIGVEFASRIVKLGTGSRRRRIKLQLWDTAGTERFRSVSRSYYRGAAGAILVYDVSSYASFAALPTFLMDARALASPNLTVLLAGNKADLADSTDYHDDAHRAPPTPSSTSSKQSSYPFDMTGSVRSTSTANYLGPGTRMTASFAEGREVSKEDTARWAAQSNIPVAVEISALTGDGVEEVFQRLARIILTKIELGEIDPDDPQSGIQYGDGGMYGGGHGASEASSIRSRTTIDENSIAMHRSSRRRGRPTSSWKGGMREWEDVFRLNGSSSKRNRGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2H2</accession>
    <name>A0A9W9X2H2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788614.1">
        <property type="nucleotide sequence ID" value="XM_056936679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2H2"/>
    <dbReference type="GeneID" id="81626928"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5481184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="142" mass="15163" checksum="A2E8934F65DB33A5" modified="2023-11-08" version="1">MVALMKARVLKVLNPDSKVTWNERNGSGWTVTDQDGKSNPVKTENSLLKDLLTTKQCRPDTRAGGSDTGALAMSPMPERVVGDDGKPNVGLFAIGVPTEGARWVTTAVPRPLADSVLLRSADAVARAALRQAQKDLLDKKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X327</accession>
    <name>A0A9W9X327_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">xanthine dehydrogenase</fullName>
            <ecNumber evidence="4">1.17.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">N7539_006181</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hypoxanthine + NAD(+) + H2O = xanthine + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24670"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>xanthine + NAD(+) + H2O = urate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="20">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="20">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.4" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788707.1">
        <property type="nucleotide sequence ID" value="XM_056935783.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81626032"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004854">
        <property type="term" value="F:xanthine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000015">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000003">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.50:FF:000001">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000002">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014307">
        <property type="entry name" value="Xanthine_DH_ssu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02963">
        <property type="entry name" value="xanthine_xdhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 20" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 20" id="KW-0408">Iron</keyword>
    <keyword evidence="12 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 20" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="21">
        <location>
            <begin position="34"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="22">
        <location>
            <begin position="265"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="1294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="178"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5484017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="241" mass="27256" checksum="8E9C5B8CF84927FE" modified="2023-11-08" version="1">MHRSTVSRVAQHGVSALAELPPPYLAPSLHFSKSRAPIQTSSFSTTSAVAARRGRDMNRTRGVSAIHGTGPRFPLSASKYPLPKPVSRDQMKARPSTPNHGLWGFFPPTHEALSTTEYDAAFGRPWSVQELRNKSWDDLHKLWWVCVKERNRIATSNLERSRLKAGFGDHEANQRDDAIVVTQKTIKHVLRERFYAWEDASRLYAKGYRPQDQDSMEEAALEEMTPAEDPFKEGSVKETKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X520</accession>
    <name>A0A9W9X520_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione S-transferase kappa</fullName>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_005858</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GST superfamily. Kappa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789332.1">
        <property type="nucleotide sequence ID" value="XM_056935460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X520"/>
    <dbReference type="GeneID" id="81625709"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000096">
        <property type="entry name" value="Glutathione S-transferase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014440">
        <property type="entry name" value="HCCAis_GSTk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF13">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006386">
        <property type="entry name" value="HCCAis_GSTk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="6">
        <location>
            <begin position="5"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5484062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="234" mass="26868" checksum="0271D1A9DE3A4538" modified="2023-11-08" version="1">MSCKIDAYVDCVSPYSFLAAHYLRRNRKALESHGVEIEFHPVFLGGVNVGSGNKPPWTLPAKAAYSKFDLARASKYFGVPAVKAPDFFPILTIMILIVHTPFRLKPQRGMIYIKRHFPRERFETTLLSLTEWIFYKSIDISKPENLTKLLQSQQYSDSEIQAILGAAKDPEYKEALTYNTQKALDLGAFGAPWFWVRNQAGAEEPFFGSDRFNFMWQFLDIPFQDLTIIEKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X533</accession>
    <name>A0A9W9X533_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_005787</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789261.1">
        <property type="nucleotide sequence ID" value="XM_056935389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X533"/>
    <dbReference type="GeneID" id="81625638"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="4"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5483991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="634" mass="70407" checksum="1F6D5DEF151526E3" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X571</accession>
    <name>A0A9W9X571_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Meiotically up-regulated gene 154 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_005832</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789306.1">
        <property type="nucleotide sequence ID" value="XM_056935434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X571"/>
    <dbReference type="GeneID" id="81625683"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018819">
        <property type="entry name" value="Nur1/Mug154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293:SF1">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10332">
        <property type="entry name" value="DUF2418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="406"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5484036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="50597" checksum="ED08F43B246D125A" modified="2023-11-08" version="1">MPRLVRRQPLAERIRSFLNPWDFLLWLSESIEGYDWDQLEKDWGLTIGVLLNFVFLIARANSGSSGSEAIDDVFGDNDGVPWLSWFGSAVVHVLGLFSFVNAIYTFQKKRYYRFFEAPIDTAPASSSASRVRVDSSPMVATPLRYLANVISSESAHSRAHPDAHRDVWELAMWDPLPISIRLLCLFSPGHVLVYYLFLPTQLSDPRPSVTVATTILLTVLLSVQMSFISSFYKQQAKDSLLVHREVLKEYDTKFVHPRTQPLMRDVGTQFTEKSDLVPTSGSPNKVETYTPTFIVNRGFRTSPNPNYLSHVDPEGLSPRRPRTSTPTATSIFQTQPSLQTPVISREGTPLVRTVKTNMRQPQFRTQSAMSGDGGSLGVYSHANSPLRKSASTAFDRRLQSNGDFFYTERGASPLRKQSSPLKRSSLAGPMGSSAPGPQPANQGSTNRRETGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5K4</accession>
    <name>A0A9W9X5K4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_005904</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789378.1">
        <property type="nucleotide sequence ID" value="XM_056935506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5K4"/>
    <dbReference type="GeneID" id="81625755"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040941717" description="mannan endo-1,4-beta-mannosidase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="11">
        <location>
            <begin position="40"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5484108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="350" mass="38500" checksum="E617F030D63A7568" modified="2023-11-08" version="1">MKLFSFAAALYGISSLTGALAAKSFSASNLYYAAGLTDSQSTTLLEGLQSAGVKVLRVWLDGQSDSQKGTNIDPFPGLQGYNPTPYDDTVLERLDDLMVKAHDYGIKLLISIHSYNALENNVDFYGKWYGTGYFYTDANAIQYYKDRVAHVLSHVNSKTGKAWSESSEYIFAFETQNEAMHDQENPDALTKWQCTIAQSIKDNLNGNSNILVATGGGAWLANSLLDPYFSCDALDVLSIHAYGVGDFATSALQPYVTKAQNAGKKLIMEEWGSCYTDTSNHNYSNIREWASSITAAGIPWFYWQILPNADPHYGWDYEVGINDVNWDALKAAGLAAGNAEAAFDFSPYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5M1</accession>
    <name>A0A9W9X5M1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_004735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789531.1">
        <property type="nucleotide sequence ID" value="XM_056934337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5M1"/>
    <dbReference type="GeneID" id="81624586"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="82"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="288"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5484747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="353" mass="39142" checksum="358AB8142DA1A72C" modified="2023-11-08" version="1">MAYQLYSRGSVRSATPQISSPLPPTTRQPQPPIHPVPPQLPRSAATSPRATAAATTTAQSQESLAPYRGDFSTSHSTPHPHITVESVRTVHIPSLTRITSLLLPIRYPNSFYTNIITDPVVASLSRVAVYHDHPVAAVPKSSGSSGSEKVIGGIRCRLEQQDSNYQIQGRVATNLYIQTLHLLSPYRGHGVAASLLDSLLYAPSDDVGRKHKVSHIVKHYNIRSVTAHVHEANEDGLRWYVARGFKVQDGIVEGYYRRLQPSGAKIVRLDVQWDDQAEDHDQFCEAHVAQEESPNTTSSDAEDEGWEKVEADHDDDNHGVQPLDESRVLDRTDSTLSRKRKAEEESAHLPQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5R8</accession>
    <name>A0A9W9X5R8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Synaptobrevin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_004823</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789619.1">
        <property type="nucleotide sequence ID" value="XM_056934425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5R8"/>
    <dbReference type="GeneID" id="81624674"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15874">
        <property type="entry name" value="R-SNARE_Snc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000063">
        <property type="entry name" value="Synaptobrevin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005409">
        <property type="entry name" value="Synaptobrevin_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="30"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5484835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="119" mass="13131" checksum="E8B7B54017F2ACED" modified="2023-11-08" version="1">MSGEAPYDPYIPAGSSGPGAASAQQHGNQRTAALQAQIDDTVGVMRENINKVSQRGERLDSLQDKTDNLAVSAQGFRRGANRVRKNMWWKDMKMRVCLVVCVIVLLLVIIVPVAMHFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5S1</accession>
    <name>A0A9W9X5S1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_004872</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789668.1">
        <property type="nucleotide sequence ID" value="XM_056934474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5S1"/>
    <dbReference type="GeneID" id="81624723"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF39">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="64"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5484884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="567" mass="61360" checksum="EB8434C425C99FC1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X696</accession>
    <name>A0A9W9X696_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_005775</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the F-actin capping complex, composed of a heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5483979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789249.1">
        <property type="nucleotide sequence ID" value="XM_056935377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X696"/>
    <dbReference type="GeneID" id="81625626"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.570:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000005">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043175">
        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6 10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5483979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="262" mass="29360" checksum="481BCE41AF22060C" modified="2023-11-08" version="1">MADAQFDSALDLLRRLNPRDTKANLQAITSIVPDLTEDLLSSVDQPLEIRRCPQTGRDYLLCDYNRDGDSYRSPWSNEFDPPLEDGTVPSERVRKLEVAANEAFDVYRELYYEGGVGSVYFWDLDDGFAGVILLKKGVTAGSQSSGEWDSIHVFEATDRARMSHYKLTSTVILHLANETEALGQMDLSGNMTRQVEADLPVESDASHIANVGRLVEDMELKMRNLLQEVYFGKAKDVVGLGSLSESNRDRATQLEMIRGMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6I2</accession>
    <name>A0A9W9X6I2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789369.1">
        <property type="nucleotide sequence ID" value="XM_056935497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6I2"/>
    <dbReference type="GeneID" id="81625746"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5484099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="159" mass="22105" checksum="2377140F53F44766" modified="2023-11-08" version="1">MCQGDHFSPCPVALIVVAAENHCHPYGHTPASTPLHLTSWREYRDRILVPPSILGNSLHHSQIRRLSYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYSLSERILKRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6M6</accession>
    <name>A0A9W9X6M6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_005245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790041.1">
        <property type="nucleotide sequence ID" value="XM_056934847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6M6"/>
    <dbReference type="GeneID" id="81625096"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5485257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="371" mass="42241" checksum="B6C5CC22C9FD62EF" modified="2023-11-08" version="1">MSTRTAKSRSRQKSCTICAEGKRRCNRQTPQCSRCSERGLRCTYLNSPRMKTRPSTVDSASPLSDIRSDMDTDFEISFARVSSHPDMWTDSSTLAASRHFDRSPSLPTMPNFCPAIFFPDIVRPDQWSTEKLLRNINSFPELFARSGATPFLHPQLYGSDMPTAMQDAFAVTAAYFSRTPETEALTVRVLENKSKSLMKQLQKISSLRELLASVQALLIFQIIQLFQGTSRQRNLAEQDMEMLRSWTTRLQIQGEDLVNPNTWQDWIFLESIRRTVIISVLLDSLYWSLKFGHCTQAKILSMLPVTPVSELWECPTSTDWPGSIPTRSQTLLYGDFSMAWKEGRVTGELDEFQKFLLVPCVGANYKDLLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6U4</accession>
    <name>A0A9W9X6U4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_005174</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789970.1">
        <property type="nucleotide sequence ID" value="XM_056934776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6U4"/>
    <dbReference type="GeneID" id="81625025"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="94"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="632"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5485186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="673" mass="76342" checksum="8590CD45C4FD63A7" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6Z4</accession>
    <name>A0A9W9X6Z4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General alpha-glucoside permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_005425</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790221.1">
        <property type="nucleotide sequence ID" value="XM_056935027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6Z4"/>
    <dbReference type="GeneID" id="81625276"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="396"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="48"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="518"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5485437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="546" mass="60929" checksum="53531E6ED711916A" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X702</accession>
    <name>A0A9W9X702_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA ligase</fullName>
            <ecNumber evidence="12">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">N7539_005616</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="12"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790412.1">
        <property type="nucleotide sequence ID" value="XM_056935218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X702"/>
    <dbReference type="GeneID" id="81625467"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000004">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000016">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
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            <end position="734"/>
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            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAJ5485628.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
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    <sequence length="875" mass="96318" checksum="52163955C7637AB1" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XCE6</accession>
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        </recommendedName>
    </protein>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE51</accession>
    <name>A0A9W9XE51_9EURO</name>
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        </submittedName>
    </protein>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">IBT 30728</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040860792" evidence="2">
        <location>
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            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5489203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="269" mass="26984" checksum="A11C4F3826D0E878" modified="2023-11-08" version="1">MHATYLTLAAFAVAVAAVPDVPVPSGNPFEGGSYPFLSAGSSAVEDGGDDFMPAYEAAMQAMEIVQSASYSKSVSASVAASRQATSSTKAAPTQAFDKVEKPTGASQAWSTSQGSAVAAATPSAGSSKKNAVVYEYASTMSVSASYPGHSNMAPMVVNEVTATSDYFSKDLMAPTTITPVFAQKATSVSGSQLPSGFVTVASMTTPTPVKPSNNLHQGHLASASAAQSSARKADSSSSASLSPSAVASDATSMLGKIPVLGSLFGNLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEG4</accession>
    <name>A0A9W9XEG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791416.1">
        <property type="nucleotide sequence ID" value="XM_056933875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEG4"/>
    <dbReference type="GeneID" id="81624124"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="90" mass="11869" checksum="98C62518E0954F7D" modified="2023-11-08" version="1">MRGNGRASKGLHALLDSGSGQGERHPSDAPSLEGMWRTANYYYYYDYYDYYDYYDYYDYYDYYDYYDYYYYYYYYYYYYYYYYYYYYYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEN9</accession>
    <name>A0A9W9XEN9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_004378</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791521.1">
        <property type="nucleotide sequence ID" value="XM_056933980.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81624229"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23958">
        <property type="entry name" value="SCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000494">
        <property type="entry name" value="Sister chromatid cohesion protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026003">
        <property type="entry name" value="Cohesin_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12765">
        <property type="entry name" value="Cohesin_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="8">
        <location>
            <begin position="1379"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="575"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1647"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1717"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1650"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1719"/>
            <end position="1734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5489488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1768" mass="194619" checksum="A7F21D6F0A7DA218" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEU6</accession>
    <name>A0A9W9XEU6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_002532</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792094.1">
        <property type="nucleotide sequence ID" value="XM_056932135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEU6"/>
    <dbReference type="GeneID" id="81622384"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000010">
        <property type="entry name" value="60S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5490965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="198" mass="22246" checksum="1FD8ACADC5612D86" modified="2023-11-08" version="1">MIADDRLLFSLYRSVTPPRRFRMPRAPARAGSYLRVSFKNTRETAQAINGMKLQKALTYLDNVTKKSMAVPMRRYAGSTGRTAQGKQFGVSKARWPVKSAEFLIDLLKNAEANADIKGLDTSALVVKRIQVNQAPKGRRRTYRAHGRINPYMTNPCHIELILTEANEEVAKAPESSLKATRLSSRQRGSQLRRALTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFE2</accession>
    <name>A0A9W9XFE2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_002817</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792379.1">
        <property type="nucleotide sequence ID" value="XM_056932420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFE2"/>
    <dbReference type="GeneID" id="81622669"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000002">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF1">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ERV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="8">
        <location>
            <begin position="70"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5491250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="222" mass="24236" checksum="DC0F447D8461BF49" modified="2023-11-08" version="1">MANRQMTRRIGISAVISICLIFFLFLRPQGPLSPAVRAPGHINHGGNAASGVVIQPDTLKGAVIMPKLGNATAKAELGRATWKYFHTVMARFPEKPTEDQQDALRSYIHLFARLYPCGECAEHFQQHLNKYPPQVSSRNAAAGWACFIHNEVNAMLEKPEFDCTNLGAFYDCGCAEDEAKGDDGKDKEKSKEAGHSATTRGDGKQDAGDAHDHLAVEISKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFH1</accession>
    <name>A0A9W9XFH1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chitin-binding type-4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_002535</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the polysaccharide monooxygenase AA13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792097.1">
        <property type="nucleotide sequence ID" value="XM_056932138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFH1"/>
    <dbReference type="GeneID" id="81622387"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052282">
        <property type="entry name" value="Starch-active_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36575">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36575:SF2">
        <property type="entry name" value="CHITIN-BINDING TYPE-4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040872577" description="Chitin-binding type-4 domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="9">
        <location>
            <begin position="21"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5490968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="291" mass="29947" checksum="0CE6917349ED6088" modified="2023-11-08" version="1">MKSFAATTAALAALLPLVHGHGFVTSPQPRMPGPAMKAACGNQVEINQQSDNYGNIQGELQVAATQNDYNAAECDIWLCKGYKFDDNKDNVFSYKAGQTIDFGVDIRAPHTGVANVSVVDTASNSVIGQPLISWDVYASTATGVKPDETSFKVTLPTDLPSKCATAGNCVLQWYWYAQSIDQTYESCIDFTVGGGSASGSGSSSSGSTTSMPATAKTTTAAVQSSSASVQPLTTLATQARQGTTPTQAAGSNSGSSSSSNGAGTAASGIPTGSAQDTLEYVRAVFQYLAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFM1</accession>
    <name>A0A9W9XFM1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc finger C2H2 LYAR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_002818</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UPF0743 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792380.1">
        <property type="nucleotide sequence ID" value="XM_056932421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFM1"/>
    <dbReference type="GeneID" id="81622670"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.490:FF:000001">
        <property type="entry name" value="cell growth-regulating nucleolar protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039999">
        <property type="entry name" value="LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014898">
        <property type="entry name" value="Znf_C2H2_LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100:SF10">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08790">
        <property type="entry name" value="zf-LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51804">
        <property type="entry name" value="ZF_C2HC_LYAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger C2H2 LYAR-type" evidence="10">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="217"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="368"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5491251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="547" mass="60611" checksum="26F47025572AD108" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG96</accession>
    <name>A0A9W9XG96_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792792.1">
        <property type="nucleotide sequence ID" value="XM_056932833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG96"/>
    <dbReference type="GeneID" id="81623082"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5491664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="86" mass="9738" checksum="20CC3AA2FE093701" modified="2023-11-08" version="1">MTYVAATDRTTIGGEGEVPGDQLQHLQQEVQHEAQHEAQQYRRAIYALIEKIRHCGDEELQELLRSIRNADSLAEATEKAVALKYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGU5</accession>
    <name>A0A9W9XGU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13 14">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="5 13 14">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">N7539_001529</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13 14">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13 14">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="5 13 14"/>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793163.1">
        <property type="nucleotide sequence ID" value="XM_056931132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGU5"/>
    <dbReference type="GeneID" id="81621381"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.180:FF:000001">
        <property type="entry name" value="Endo-1,4-beta-xylanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033119">
        <property type="entry name" value="GH11_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00777">
        <property type="entry name" value="GH11_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11 13 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 13 14" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="7 13 14" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040864760" description="Endo-1,4-beta-xylanase" evidence="15">
        <location>
            <begin position="20"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="16">
        <location>
            <begin position="29"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5492783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="218" mass="23821" checksum="22E41676B140A5B3" modified="2023-11-08" version="1">MVSFTKLFVAAAVAVGAWSAPTELVERQTITNSQVGTNNGFYYSFWTNGGGQVSYTNGAAGQYSVNWNNAGDFTCGKGWAKGAARNIKYTANFKPSGNAYLGVYGWTKGPLIEYYILENYGSYNPGSGMEHKGTVYSDGSNYDIYQHTQYNQPSISGTQTFNQYWSIRQNKRSSGTVTTGNHFNAWAQHGMQLGQHDYQILLTEGYQSSGSSSVTVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHD8</accession>
    <name>A0A9W9XHD8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040752569" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="23996" checksum="D58EBC69CDAC05B2" modified="2023-11-08" version="1">MRTVIATLFLASTALASTSVTDDFIDCATAAINGVSGSKTIDCSNQSSSDCFCANQDALTKISDALKDACDVSSSDLAAWASSLCGTSSTSQDTSSARHIGSPMEPARVLNERAYSASVENNVPTSVVWVTETRTDCSCKSTSHPADRAHASQIPVYVPTGSSMSSGVAAWATPTPSASASWSAMHSSHMSVATPGPSGASPSIYTFEGAAPRVNALQGSVAAIGATIVMGLMVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHP7</accession>
    <name>A0A9W9XHP7_9EURO</name>
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        <recommendedName>
            <fullName evidence="7">SAGA complex subunit Spt7</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
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    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="405"/>
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        </location>
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            <end position="339"/>
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            <begin position="33"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1138" mass="124609" checksum="EA0789BE3F554D21" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI66</accession>
    <name>A0A9W9XI66_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Catabolic 3-dehydroquinase</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
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            <begin position="56"/>
            <end position="67"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5492829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="116" mass="13359" checksum="2EC4B91CF98DD8BF" modified="2023-11-08" version="1">MTDMTFSHLFTDKCPGPKKKKAWSGGLPIDDFIKTPIEGRANDDLHHAPRERHARRPEPIDPASRRQHESHHHAALQLGRDGLNFDVECDCRFINFCLKEGLEWKAFYDLYAAMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="4">Dystroglycan-type cadherin-like domain-containing protein</fullName>
        </recommendedName>
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                <person name="Petersen C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">IBT 30728</strain>
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    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="nucleotide sequence ID" value="XM_056931801.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05345">
        <property type="entry name" value="He_PIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040854831" description="Dystroglycan-type cadherin-like domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="4">
        <location>
            <begin position="23"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="4">
        <location>
            <begin position="133"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5493452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="894" mass="97476" checksum="0E997BED3DD7F32B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIU3</accession>
    <name>A0A9W9XIU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_002086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793720.1">
        <property type="nucleotide sequence ID" value="XM_056931689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIU3"/>
    <dbReference type="GeneID" id="81621938"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF18">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5493340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="230" mass="25285" checksum="C5BCC3C4414189C3" modified="2023-11-08" version="1">MLEYSLTPEHPFPCQLIQAVAALRYLLLDKELSVEDMILGGDSAGGHLILSLLTHLISPSPYAPSLDLQGRQLKAIVLVSPWASLSWPQAQQLPSAKGDYLTRTAIEHFYLMAKEPTDDIWALQCEKDKLLSVWKQLYPGPPADSISQKLILAVGDLEILYESCMDFGQEILGLDVVHVCDPQELDLTRQLNYVLAVAPGEAHVQPALDCAVGYDNGNMLRSILGFLGTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XKZ9</accession>
    <name>A0A9W9XKZ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_000058</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793955.1">
        <property type="nucleotide sequence ID" value="XM_056929662.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81619911"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001010">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="597"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="629"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="664"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="770"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1191"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1215"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1256"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1299"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1326"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1451"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="153"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="846"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5494942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1477" mass="164986" checksum="0E474B43201582CC" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLI0</accession>
    <name>A0A9W9XLI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymethylenebutenolidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_000293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794190.1">
        <property type="nucleotide sequence ID" value="XM_056929897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLI0"/>
    <dbReference type="GeneID" id="81620146"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5495177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="46308" checksum="EA31AF6BAF67BA77" modified="2023-11-08" version="1">MFNDISLPPPPLPASERTQLAPGIARLLPLSRRGYGPGLILLGPDTDQPTQIVDGVPSHLVKWAEEGYAVVEIQRQALVDRPEEALTQAVEALEACDKCIPKDKIGLIAYDYESWNHVVSALTTIPAIVAGVIFGSLSSSPVSESAGLPILQHLAGKKPDTPSQNDGLKVFYYPNAKSHRFATPFQDEFDYWAESVSHTRTLQFLKPFLNGPYFDLEHIWEEHTYYEFADRSVDHTMSTMVDQPYVNHVPTLTGGIGRERLHNFYLHSFIFNNSDDTDLELISRTVGIDRVVDEFIFKFTHDKQLDWLLPGVPPTHKHVEVPFTAVVNIRGDRLYHEHISWDQGSVLRQLGLLPDYLPYPYALPDGTQPAAGKRFEYRVPVAGVESANKMRDHHSIASNQMFGYRLREVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLI1</accession>
    <name>A0A9W9XLI1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter ATP-binding protein ARB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_000189</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794086.1">
        <property type="nucleotide sequence ID" value="XM_056929793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLI1"/>
    <dbReference type="GeneID" id="81620042"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000549">
        <property type="entry name" value="ABC transporter ATP-binding protein arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000618">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="80"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="391"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5495073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="612" mass="68212" checksum="5806D436312C0E52" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLP8</accession>
    <name>A0A9W9XLP8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Chitin synthase</fullName>
            <ecNumber evidence="2 9">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_000448</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chitin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 9"/>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794345.1">
        <property type="nucleotide sequence ID" value="XM_056930052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLP8"/>
    <dbReference type="GeneID" id="81620301"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF39">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="525"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="615"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="659"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="696"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="11">
        <location>
            <begin position="100"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5495332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="832" mass="94944" checksum="E1A349AA55C5AEE2" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLY4</accession>
    <name>A0A9W9XLY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome transmission fidelity protein 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794499.1">
        <property type="nucleotide sequence ID" value="XM_056930206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLY4"/>
    <dbReference type="GeneID" id="81620455"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY PROTEIN 18 HOMOLOG"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="377"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
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        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="965"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1053" mass="116891" checksum="B5E4E167DD842FF8" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XLZ6</accession>
    <name>A0A9W9XLZ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_000146</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794043.1">
        <property type="nucleotide sequence ID" value="XM_056929750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XLZ6"/>
    <dbReference type="GeneID" id="81619999"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5495030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="33442" checksum="F0B0F2C77A9F01E7" modified="2023-11-08" version="1">MTTQDERASEGPPPWYETDVKSINPKAQSLLEEYSGFAPDEVLPHVLKLRDEAFKIFPYPCIGQMRFLSCHLSNFPYYQRIHDKLHSRATGTTFLDAGCCVGQELRFLHTRAQVPAENLYGLDLEPEFFSIGYELFRDNAATFPATLVAADIQADEDTWAGSRAVTAMKGRMDVIWASSFLHLWDYEGQARALERLLGLCRDETGVVVGGRQMGSVLAGEYTVDSIGGRKEWKQYRHNGESLKGLWFDVERRLGQRWELEVQLENGETMRKMRGASFMDDQARVIWWIATRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XM89</accession>
    <name>A0A9W9XM89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b-c1 complex subunit 2, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Core protein II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">N7539_000702</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794599.1">
        <property type="nucleotide sequence ID" value="XM_056930306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XM89"/>
    <dbReference type="GeneID" id="81620555"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000021">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000039">
        <property type="entry name" value="Ubiquinol-cytochrome c reductase core subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF209">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="13">
        <location>
            <begin position="47"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="14">
        <location>
            <begin position="194"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5495586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="456" mass="48356" checksum="C32442E23AFC0557" modified="2023-11-08" version="1">MLSRSSLSRNAPRALSAGRRAMASSANPSFQYDVTETAGVKVANREVTGPTGTLALVAKAGSRYQPFPGFADALEKFAFKTTLKRSALRITREVELLGGEITSTHSRENVVLRTKFIADKLPYFTELLAETTSQPRFADHELNEVVKDLLKYQQQAAFAKPENVALDAAHGVAFHRGLGTSITPSTNTPYEKYMSADAIAEYAKDAYSKSNIALVSVGPNAADVNKWVGQFFKDLPTGSSSSQFKVQPSAASKYYGGEQRIASKAGNAVVMAFPGSSAFGSSGFKPEATVLAALLGGESTIKWTPGFSLLSQATQEFRGLNVSTQNFAYSDAGLFTVTLTGRAEQVGAASKNVVDALKKAAAGEVSSEDIKKATALAKFRALESVQTLETGLEATGSGLIHGAKAYQIGEIAQAIENVSEQQVKDVAKSFLSGKATLVSVGDVFQLPYAEDLGLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XML8</accession>
    <name>A0A9W9XML8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_000165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794062.1">
        <property type="nucleotide sequence ID" value="XM_056929769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XML8"/>
    <dbReference type="GeneID" id="81620018"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00481">
        <property type="entry name" value="Ribosomal_eL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000231">
        <property type="entry name" value="Ribosomal_eL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="11"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5495049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="106" mass="11332" checksum="D91619E2FC11D70E" modified="2023-11-08" version="1">MAKTKKSGDTLASRLALVMKSGKVTMGSKSTMKTLRSGKAKLVLIAGNCPPLRKSELEYYAMLAKVPVHHFNGNNIELGTACGKLFRCSTMAVLDAGDSDILSREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN12</accession>
    <name>A0A9W9XN12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_000616</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794513.1">
        <property type="nucleotide sequence ID" value="XM_056930220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN12"/>
    <dbReference type="GeneID" id="81620469"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF27">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5495500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="138" mass="15583" checksum="248B2E26087C1E4F" modified="2023-11-08" version="1">MDHVKGMMDHSERAKHGTGDTGNGTYMAMPMVFTFSTKVTILFSWWSTIYPHGVDPHPRLDHSLRPHRKWNWSQDIIGSMLEGVRAFTGYALMLAVMTYNVGILCAVIMGILIGEVFLGHFSMPTPSSRWQDRVCHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN18</accession>
    <name>A0A9W9XN18_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795024.1">
        <property type="nucleotide sequence ID" value="XM_056930731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN18"/>
    <dbReference type="GeneID" id="81620980"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5496011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="365" mass="40746" checksum="9972A5737BA4E907" modified="2023-11-08" version="1">MSSIQASYPRYFYHPSGGIYALPGHVHSGHFHPVLVRERNGSIHTKPPRTTKCSSPTTPPAERRAYAAREQARKETRPPAPGEESDSSNSASSKASHLRGSSRYYFHPIHGRSDSTEKLSTKNSQKIPHKSSKAPRSPDSDTESKYSNGEYAPVCSHSPHRLHPPHAYRHSYHGLAPEHYVIKVPVPSHCPDCCQSIAQHTPETVPAAKPQAHPPAEAPKEKFRKSNAARTPHGNDFAKASGPSMARVVCHCGLVHFDVPSPHPQPQSQKALPREHKHESRGKFVEREQVRPHGHRHRHTRYRKHRHHDSSSSSDTDPTEHEDTSSESSVDAQVGHARFGFEVPADDWEVCSEKCCGHPVLYIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XN87</accession>
    <name>A0A9W9XN87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795120.1">
        <property type="nucleotide sequence ID" value="XM_056930827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XN87"/>
    <dbReference type="GeneID" id="81621076"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5496107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="93" mass="10366" checksum="85163001A898CFDC" modified="2023-11-08" version="1">MNWWLDRWPNTGSIIDDPAADPLCRPGTPRSKESKKEKKKKYQDEKSGADQASVIIACLVDHVCPASGFMDVFPMYGERAPALWATSLVPSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XNM6</accession>
    <name>A0A9W9XNM6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial aspartate-glutamate transporter AGC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Aspartate-glutamate carrier 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">N7539_000675</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794572.1">
        <property type="nucleotide sequence ID" value="XM_056930279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XNM6"/>
    <dbReference type="GeneID" id="81620528"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000415">
        <property type="entry name" value="Mitochondrial carrier protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="174"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="343"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="442"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="540"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5495559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="695" mass="77229" checksum="F0F1BF48FA397340" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XNW3</accession>
    <name>A0A9W9XNW3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795048.1">
        <property type="nucleotide sequence ID" value="XM_056930755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XNW3"/>
    <dbReference type="GeneID" id="81621004"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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    </gene>
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            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Nielsen M.R."/>
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                <person name="Sorensen J.L."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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    </reference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    </reference>
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        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
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                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:rRNA base methylation"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="84"/>
            <end position="387"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5466736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="439" mass="47480" checksum="6ABFC199029A0679" modified="2023-11-08" version="1">MPRKKQKSGPAPRANRPGAGVNGGGPAKNGSGPASQHVKNKKTVASNAASGASQDGTGGAGQKKQSLQANQRPIVPFLKGDRILLVGEGDFSFARSLAKQYKCRKLCATCYDSKETLFSKYPQAEQHIQEILNSASLKRKSTEDAALDNEESTSSPATKDEADKSHQQTASSSRKPSPKVLFSVDARKLGTPAGGSKEVRTGFPRKERKIPAWKLARQMNAQSQLHSRAKVRFTHGAQATPGKGESSAGGPWDVICFNFPHVGGLSTDVNRQVRANQELLVAFFKACVPLLSKAPPPVDEDDLEEDGDGESDASELSDSDDGADDEEKRATSGNAVRTGPGQILVSLFEGEPYTLWNVKDLARHAGLQVVTSFRFPWAEYEGYSHARTLGEVEGKDGGRGGWRGEDRLARMYVFEVKPEEKPAKNQKNKRSWEGDSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BM23</accession>
    <name>A0A9X0BM23_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786423.1">
        <property type="nucleotide sequence ID" value="XM_056938415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BM23"/>
    <dbReference type="GeneID" id="81628665"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5471877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="32914" checksum="26F77773C2FA2849" modified="2023-11-08" version="1">MALGSSANSIEILQMKTLALATCARLPLIYPFVPISNVLSSELRASLYRFGAFRLAAPDTTQRNYKTVVQKPVATKMNATKYSAFASERVRGKTAIYKESAYYFRNDVEPKYSKGPSDNLFLSVKALNTELAPIRLDLLNTLSQVLSQSPAKDDVTLTGDSALNSTTVGVHYYDPFRCLSDRSEYLSPSHKDSGTLTILFRTHGKDDGLGVADLETTEKRGSEDVGSEASYQSLPGSDMTEVVVFAGIRLQNLIGQDRVRASVHRVRAPSPESCTESCVPRFSIVMFCAPSIPAARITPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BM27</accession>
    <name>A0A9X0BM27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000014">
        <property type="protein sequence ID" value="KAJ5471892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786438.1">
        <property type="nucleotide sequence ID" value="XM_056938430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BM27"/>
    <dbReference type="GeneID" id="81628680"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5471892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="120" mass="13258" checksum="4D5D7E3AB8E9722C" modified="2023-11-08" version="1">MSEVIATMLLFQFEGASDIVRRDMAIAWSPVVLIDLSIIEMLVGMVCWYSSKTKRGNGALMAVYLAVLLSFGIGLSAWMFRKWLSPNETSSVNEERVPPVEVTPYSKVVVPEPEGMTAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BN80</accession>
    <name>A0A9X0BN80_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_007708</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787174.1">
        <property type="nucleotide sequence ID" value="XM_056937309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BN80"/>
    <dbReference type="GeneID" id="81627558"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001827">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="159"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="527"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="431"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5475421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="557" mass="61581" checksum="B2352C0AA3B4B322" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNF0</accession>
    <name>A0A9X0BNF0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc fingerFYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_007903</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787369.1">
        <property type="nucleotide sequence ID" value="XM_056937504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNF0"/>
    <dbReference type="GeneID" id="81627753"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15761">
        <property type="entry name" value="FYVE1_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15737">
        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="200"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="339"/>
            <end position="416"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5475616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="672" mass="74710" checksum="06E3F3847B4C8594" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNP3</accession>
    <name>A0A9X0BNP3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_007724</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787190.1">
        <property type="nucleotide sequence ID" value="XM_056937325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BNP3"/>
    <dbReference type="GeneID" id="81627574"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056121">
        <property type="entry name" value="DUF7704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24803">
        <property type="entry name" value="DUF7704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040772543" description="DUF7704 domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7704" evidence="3">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5475437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="155" mass="16561" checksum="0B10AEC7F3BDADDA" modified="2023-11-08" version="1">MPTILPPWPHLLFGVLEPISLVLGSLAPLVDVESFISGQTFQATPPVAHPSSVSLAYQVGNLYSLLCLVGVAVLHTTTEPQVVRNYLIALAIADVGHVCATYMGLGWAAFVDYSAWNALTWGNIGATAFLFVNRLAYFTGIFGTAKVPKAEGKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BNU2</accession>
    <name>A0A9X0BNU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-C homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_007106</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-C/MIF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5476962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787506.1">
        <property type="nucleotide sequence ID" value="XM_056936707.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81626956"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06993">
        <property type="entry name" value="cupin_CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000033">
        <property type="entry name" value="Centromere protein C 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028386">
        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025974">
        <property type="entry name" value="Mif2/CENP-C_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028929">
        <property type="entry name" value="Mif2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684:SF11">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11699">
        <property type="entry name" value="CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15624">
        <property type="entry name" value="Mif2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mif2 N-terminal" evidence="9">
        <location>
            <begin position="13"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Mif2/CENP-C cupin" evidence="8">
        <location>
            <begin position="476"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="389"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="567"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF15624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5476962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="621" mass="68003" checksum="694395CC98F97E49" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BP74</accession>
    <name>A0A9X0BP74_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_007315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787715.1">
        <property type="nucleotide sequence ID" value="XM_056936916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BP74"/>
    <dbReference type="GeneID" id="81627165"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307:SF11">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25788">
        <property type="entry name" value="Ig_Rha78A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial alpha-L-rhamnosidase N-terminal" evidence="5">
        <location>
            <begin position="281"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase concanavalin-like" evidence="4">
        <location>
            <begin position="472"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="6">
        <location>
            <begin position="584"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="7">
        <location>
            <begin position="902"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5477171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1003" mass="114041" checksum="E3172DBC03564A63" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSE8</accession>
    <name>A0A9X0BSE8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_006918</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788454.1">
        <property type="nucleotide sequence ID" value="XM_056936519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSE8"/>
    <dbReference type="GeneID" id="81626768"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF5">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040829014" description="alpha-1,2-Mannosidase" evidence="9">
        <location>
            <begin position="36"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="596"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="829"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1018"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="834"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1019"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="589"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5481024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1124" mass="123191" checksum="5288C2F785CD7502" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSH0</accession>
    <name>A0A9X0BSH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_006847</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788383.1">
        <property type="nucleotide sequence ID" value="XM_056936448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSH0"/>
    <dbReference type="GeneID" id="81626697"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13971">
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    </dbReference>
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        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044095">
        <property type="entry name" value="ADCK2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052402">
        <property type="entry name" value="ADCK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
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        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2 (PREDICTED)"/>
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    </dbReference>
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        <property type="entry name" value="ABC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="192"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="282"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5480953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="674" mass="76663" checksum="0693C47BDA724D3B" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BSW7</accession>
    <name>A0A9X0BSW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Assembly chaperone of rpl4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788622.1">
        <property type="nucleotide sequence ID" value="XM_056935698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BSW7"/>
    <dbReference type="GeneID" id="81625947"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
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        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5482650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="399" mass="44363" checksum="9107B0F238379CE2" modified="2023-11-08" version="1">MGKPRPQKKRSSKSRTKPVLGPGGSVSKHKMAEDPSKLLDQATILLQTGRADEALLIAQQALTLGAENPSVRLQAINLLGEINVELGEIETARDYFLNAVELDPTGSIPESDGGGAEKFMWLAQLSEQGGTDSVQWFEKGVSSLRRTLETLEGKTSPEEVLFAEEKKAKLSNALCAVAEIYMTDLSWEEDAEARCEALITEALTVTPNAPEVLQTFASIRISQTNIEEAQEALKKSISLWKDLAPEDPKVPDFAVRISLARLLMEVTLEFEALEVLERLILEDDQSVEAWYLGGWCLYLLAEKRQAPKDIVEDEASESPRHASLIASREWLKQSLKLYEKLQYEDEPLQAHALELIQGMTDEIGEDDESEAEMEGEGEDWDEEIEADSDDDEDHEMADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BT04</accession>
    <name>A0A9X0BT04_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="3 8">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_006201</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="3 8"/>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788727.1">
        <property type="nucleotide sequence ID" value="XM_056935803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BT04"/>
    <dbReference type="GeneID" id="81626052"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000004">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="11">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="9">
        <location>
            <begin position="99"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="10">
        <location>
            <begin position="546"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5482755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="666" mass="74115" checksum="C42F4723455FB721" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BU63</accession>
    <name>A0A9X0BU63_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_004816</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Lipid-anchor</topology>
            <topology evidence="1 8">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789612.1">
        <property type="nucleotide sequence ID" value="XM_056934418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BU63"/>
    <dbReference type="GeneID" id="81624667"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF11">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041019740" description="1,3-beta-glucanosyltransferase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="10">
        <location>
            <begin position="357"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5484828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="512" mass="54472" checksum="D06A92359DEE70B3" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUA0</accession>
    <name>A0A9X0BUA0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_004937</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789733.1">
        <property type="nucleotide sequence ID" value="XM_056934539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUA0"/>
    <dbReference type="GeneID" id="81624788"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09122">
        <property type="entry name" value="PLDc_Tdp1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="601"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="603"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="3">
        <location>
            <position position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5484949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="727" mass="80839" checksum="A0B861E6206FF241" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUE6</accession>
    <name>A0A9X0BUE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Folic acid synthesis protein FOL1</fullName>
            <ecNumber evidence="10">2.5.1.15</ecNumber>
            <ecNumber evidence="12">2.7.6.3</ecNumber>
            <ecNumber evidence="11">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Folic acid synthesis protein fol1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">N7539_005101</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes three sequential steps of tetrahydrofolate biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the central section; belongs to the HPPK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="10"/>
    <dbReference type="EC" id="2.7.6.3" evidence="12"/>
    <dbReference type="EC" id="4.1.2.25" evidence="11"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789897.1">
        <property type="nucleotide sequence ID" value="XM_056934703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUE6"/>
    <dbReference type="GeneID" id="81624952"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000006">
        <property type="entry name" value="Dihydropteroate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.560:FF:000005">
        <property type="entry name" value="Folic acid synthesis protein fol1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="16" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="25">
        <location>
            <begin position="198"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00012458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00013043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00058009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00061548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00067568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00068111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAJ5485113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="471" mass="51616" checksum="78E7C0A517933C55" modified="2023-11-08" version="1">MPHQESTAYPVRNGCQTHRAFIALGSNMGNRVEMIEKACLELDEANIKVLRTSSLFETTPMYVLDQDTFINGVCEVETHLSPMELLDAVQSIENALGRKKLIDKGPRSIDLDLLLYDREVFENERLSIPHKLMLERDFVLRPLCQLIPHERPPHSKSHTPTYLEHLKALPPPEPTPHSTTPISASFPSLHATDPTRNTHVMAILNLTPDSFSDGGVHSPTDMSKLTETVRKFIASGATIIDVGGESSRPGSTPVGADEEIARVVPVIAHIRKAIPEAAKIAISIDTYRARVAEAACAAGADIINDISGGLLDPDMLATAARIGKSIILMHMRGTPQTMTGLASYPNGVIPEVTAELRERIAAAEAAGIRRWRIILDPGLGFAKNQPHDLEILRKLDRLKTAEGLECFPWLMGPSRKRFIGHITGVKTPRERVWGTASTVTASVAGGADIVRVHDVHEMWQVTKVADAIYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BUF6</accession>
    <name>A0A9X0BUF6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Diaminohydroxyphosphoribosylamino-pyrimidine deaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789913.1">
        <property type="nucleotide sequence ID" value="XM_056934719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BUF6"/>
    <dbReference type="GeneID" id="81624968"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF109">
        <property type="entry name" value="RIBOSOMAL LYSINE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="35291" checksum="865B3932EB02EEF2" modified="2023-11-08" version="1">MDTAIAEFLARTASEEVVDVEEEAFYLFSQEISTPNLGFVDSRAPTLDVQIGGNEYTVHQSPSLLSSSRAGGTTGAGHPSNPLWMHSLLSEHSVVAELGCGISALVALALSPSVHHYLATDQEYVRRLFRTNIEANSSVSRVTPAAAGKSKGSKPKHSGKPPPKGKPIAQPSASNITFTTLDWEHDQPARLKACIRSESTGRGVSARDEREKVGDDEDLGFDLLLSCDCVYNDALVAPFVRTCAEICRLRPCFDSWGSRGPQAAGRPTVCIVAQQQRAPDVFETWLRETLREFRVWRLSDEVLGDRLKGGTGYLVHLLLARADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BV20</accession>
    <name>A0A9X0BV20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mesaconyl-C4 CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_005525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790321.1">
        <property type="nucleotide sequence ID" value="XM_056935127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BV20"/>
    <dbReference type="GeneID" id="81625376"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000103">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052741">
        <property type="entry name" value="Mitochondrial_HTD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152:SF2">
        <property type="entry name" value="N-TERMINAL OF MAOC-LIKE DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5485537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38403" checksum="1C69E9CE51596DA1" modified="2023-11-08" version="1">MRRFRAFSSSTRFFSADPPASTVAALFLSKFQSSGPQSRTQSLDANQLHLLSQTLGRSSDGDASSSSVIDVSGSPSIGTPVPPGYHLVYFTPGFVEDELGADGTDVSYNPQSPFTRRMWAGGEVVWPRDARGRPNPLRVGQQVRERTRVLSAEPKIVKKTGEEMIVVGVEKEFSNEEGVAVLDRRNWVFRKALPVPNPSMSTPSTSLPPSTSHLSRASASAILSEDNTHSRTFVQSPVTLFRFSALTFNPHKIHYSLPWARDVEGHRDVVVHGPLNLILMLDLWRDVQSRKNDYVGEKGILPRSISYRATSPLYAGDRYDVVLQDELDVARLQILGPGGVVAMKAEIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BV52</accession>
    <name>A0A9X0BV52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH kinase pos5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_005524</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790320.1">
        <property type="nucleotide sequence ID" value="XM_056935126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BV52"/>
    <dbReference type="GeneID" id="81625375"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF26">
        <property type="entry name" value="NADH KINASE POS5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5485536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="359" mass="38881" checksum="4C840098445545C9" modified="2023-11-08" version="1">MSRQYSHITSTYPSIAVILEPKTAAEVHESLAHPVYTARPEATPVAYHDKVDLTVTLGGDGTILHASSLFATCPNVPPVLSFSMGSLGFLSEWKFSEFKRAFREVYMSGAGAGDRTPVLETAVPSSREALTQNAEDPQPGPTGWSSVRGQWMGTTRGAPILMRNRLKVGLFAADGQEMTPVRGKTDHGEGVYVMNELLIHRGKEPHLAIVDIYLGGRFLTEAVVDGIIISTPTGSTAYSLSSGGSIVHPLVPSTLVTPICARSLSFRPLVLPWSTPITLRLSEKNRGRELEVSLDGLNLGQGMAVGMEVRVWNEDMRHGKNEWQGGVPSVMRRSMGGEAHEAWVGGLNGLLKFNYPFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BXY4</accession>
    <name>A0A9X0BXY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_003708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790851.1">
        <property type="nucleotide sequence ID" value="XM_056933310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BXY4"/>
    <dbReference type="GeneID" id="81623559"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF4">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040798173" description="GH16 domain-containing protein" evidence="4">
        <location>
            <begin position="27"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="5">
        <location>
            <begin position="158"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="441"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5488818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="497" mass="56818" checksum="CA101BDC710A5DB8" modified="2023-11-08" version="1">MKPNALLARVLSFWILTVAVASSADADPQLNPSKQHSRGEVVNFNDCDCFTVAGPDPGYFQHYKLWDFRSIPGFRQARSNASFWDEQLLSARSSDWVEEDISNDDDEEVDNDESDSIDVLDGLASNTINSTDEDASPLNELEALWFFKHAFERDWVSQDWQRPSGPHAPITMINSKDNVYFAKNRQWLDKMSTYLILRTTRLRNYTSTAEIETKARNIYHCSLRVRFRILPSNLDEESSVPLSKNLPATNEDNPFPGACAGIFTYRERNCESDIELLTKDPPSRIHYANQPDYDAVNDRMIPGASTIKDIPVPWTSWSIHRLDWLAEISRWWVDDQQQDAKTYRVPNQPSWLMMNLWSDGSLWTGDLPIGGNVYMAVEYIELAFNVSQADDSSKDSPSTYQQPEEVKPLTTEKATSTTHEDGWPDEDSEPSAQIIDGALFKKCKKGRRGRKCRKNHKKKKKQGKKPKHPHHDEPRPSACERMCNIDEMDFANGDVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYA0</accession>
    <name>A0A9X0BYA0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_004455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791598.1">
        <property type="nucleotide sequence ID" value="XM_056934057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYA0"/>
    <dbReference type="GeneID" id="81624306"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5489565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="93" mass="10456" checksum="965743C5380E7A88" modified="2023-11-08" version="1">MRRASVSTFDQVRGKYSQYTKSAVVNAYRSIAYGESWSDTPLLAAYVNGTLLVAFGSCSPHTTRSFRHFFTIASADNKQTRAAYDHRIIRANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYI5</accession>
    <name>A0A9X0BYI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791481.1">
        <property type="nucleotide sequence ID" value="XM_056933940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYI5"/>
    <dbReference type="GeneID" id="81624189"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF50">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="1">
        <location>
            <begin position="54"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="284" mass="31938" checksum="68296816EF705AB5" modified="2023-11-08" version="1">MPDTTTTTSPGEYLLIRNAAEKERLEMQFQVWQAHLGYLLHPTIKTHEHMRIADVGTGTGAWLREVAKTLPETCQLDGFDVSDALFDGRLSQVQNISFRLHNILRPFPEDLVGKYDIVNVRLLAVALSSDEWVPAVRNLIALLKPGGRLQWSDCAPQEGVIKTPSGVTPVHTKRMMEMFHKMLAALGKTPEVHRLLDIFQQCGLVSCEEEILTFEKPKVRDDLNLTIANVMAHGLAAAFELHKLEGIQSEQQITEMRDGVLDDLRTTDCFFSYDVHVVLGQKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BYM6</accession>
    <name>A0A9X0BYM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791752.1">
        <property type="nucleotide sequence ID" value="XM_056934211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BYM6"/>
    <dbReference type="GeneID" id="81624460"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="328" mass="36994" checksum="CECDFA374221293E" modified="2023-11-08" version="1">MAGHVKKEEATPQQNSTLILQGEANFSSWLHSLLCHISPAKLKILMEDEPRHDMFPYDPPLHHTLQDTDSIAHDPILSRQNTTKPVASLIHMLDETRSKEREEAFSALWATLGDEAKDLIRNTSSPCRAFTKLHLFYSKPRHFSVAARWAAWTSVHYTAGLSPGEFLRCFGKNLRELEDINGEIDAKIVFAQFMRAVANNGPISDFLIRMEIDLDDPKLMEQVCSAFVRQAMKVSPSWAPPAKPKFCYRGGGKKGPREGSVYCPFHKRMVTHSPSECRLGQRSAHGSANDTVQARGRQSNRLCRKRPRGESFAPSQGSNFKNHTSKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZ71</accession>
    <name>A0A9X0BZ71_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_002963</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792525.1">
        <property type="nucleotide sequence ID" value="XM_056932566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZ71"/>
    <dbReference type="GeneID" id="81622815"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="168"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5491396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="349" mass="38784" checksum="65316B37632D2DD6" modified="2023-11-08" version="1">MSPHQTHSPTRSPPSSRHPTPPPLHLDPISEYRACQAVQIILTVLLNRQLHRRWLLETQAVQTSRVHSTSASASASASQIYQPILHLEPIYPLIRPDLALFQPLPFSSSSSSSSSSSSSSSSLNPSLLQPLKTRIHILRARVEKGKELASEIERRMKIPAIKYPTHFCHTCVGDGQSGAAELYVMRCGHRVCRTCLVFGMDEKKVYECGICFRRLSLGRSALFDGEGTHIQREGSRERPGGVKTGTAATAATSAMYRSKSQRSTRITETQPHHHSQPRLHYQYQHDQPQPQTYHPHHHTKGLASHTGTEVGPGPQSVLRKVTHQGERDWQVDGRGVPVRGKEVLMAPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZH6</accession>
    <name>A0A9X0BZH6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792316.1">
        <property type="nucleotide sequence ID" value="XM_056932357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZH6"/>
    <dbReference type="GeneID" id="81622606"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF10">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="39150" checksum="C94637E095EADC5C" modified="2023-11-08" version="1">MSSSQENDIVQVADQLPWNPNCTKFPSLKELPKLPGAPEGAAWVWGENDQLGRLNLLTPQRVKQSAQEIVTGEMVRLDLPMNVPEQPAFDREPFKHTLKTLVDGIAYDDCYSLNTQSGTQWDGFRHFAHCETKLFYNKATGEDFVGENPNMRCSIHHWAEHCVAGRGILLDYRYYALKHNKPYDPYTSHAITLEELKACAAFQGVDIRPESQGGDIRPGDFLLIRSGFVEKYDSLSPEARYAAATRSHDNLCYAGVARDENMREWLHDCYFAGVAGDSPTFEAWPVPAMDFLHQYLLALWGCPLGEMWNLEKLAEKCRERGKWTFFLTSAPAYVPGGVGSHANATAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZN4</accession>
    <name>A0A9X0BZN4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cyclic nucleotide-binding domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_001473</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793107.1">
        <property type="nucleotide sequence ID" value="XM_056931076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZN4"/>
    <dbReference type="GeneID" id="81621325"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000057">
        <property type="entry name" value="Cyclic nucleotide-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF24">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G03170)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16643">
        <property type="entry name" value="cNMPbd_u2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="64"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="266"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="536"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="185"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="430"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="487"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5492727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="914" mass="101732" checksum="551803CA4A07DEF5" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0BZP4</accession>
    <name>A0A9X0BZP4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792857.1">
        <property type="nucleotide sequence ID" value="XM_056932898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0BZP4"/>
    <dbReference type="GeneID" id="81623147"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="145" mass="16165" checksum="6E7D05BFC6F7F416" modified="2023-11-08" version="1">MDDSNVLTILASISGWTFGVLVVIVRYTWSLLYSLLYVIAWPVLSVGRGLLSVALFPLRVLLKFEAFLTFVLGAAIVGATVGLCLYLAGDFLSRVLLLHSPELEEPLMSRSMKLEDSSTSFDWESKMYMSSTILEEEETSQDSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C0A1</accession>
    <name>A0A9X0C0A1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_001852</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793486.1">
        <property type="nucleotide sequence ID" value="XM_056931455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C0A1"/>
    <dbReference type="GeneID" id="81621704"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="10">
        <location>
            <begin position="77"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="11">
        <location>
            <begin position="242"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5493106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="785" mass="89591" checksum="55AB2A330BC2340D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2D9</accession>
    <name>A0A9X0C2D9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA ligase sidI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793977.1">
        <property type="nucleotide sequence ID" value="XM_056929684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2D9"/>
    <dbReference type="GeneID" id="81619933"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05917">
        <property type="entry name" value="FACL_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF30">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="522"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5494964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="624" mass="67888" checksum="72ABCB558E764023" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2E1</accession>
    <name>A0A9X0C2E1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_000618</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794515.1">
        <property type="nucleotide sequence ID" value="XM_056930222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2E1"/>
    <dbReference type="GeneID" id="81620471"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510:SF1">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="51"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5495502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="404" mass="45272" checksum="15E7F554D61DEB99" modified="2023-11-08" version="1">MVKIDTFAVERWMDLYENDATQNLAETCRASVSLHDLQVLSGSETDLIDYSQKQVYGAIRGSSVLRSNIARLYSSRTSDPLRPEDILVTNGAIQANFLGLYTNVGVGDHVICQYPTYQQLYSVPQSLGAEVSLWKSSEDQGWQLDVQELESMIKPNTKLIILNNPQNPTGAVLDREMLQAIVEVARQHDLIIHSDEVYRPLFHSLNSNQQDGPPSILDLGYDKVVATSSMSKAFSLAGIRVGWIASRSPAMIEEFASARDYTIISVGQLDDRVASHTLSSPTVDNLLARNYQLARRNLEDLQAFVREFAWTVSWTRPQAGTTAFLKFAKEGQPVNDVILCERLMETHGLMLVPGSLCFGNGRDFRGYVRVGYVPEREVMLEGLKALRSFMREWYEHIPVQSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2I0</accession>
    <name>A0A9X0C2I0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_000607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794504.1">
        <property type="nucleotide sequence ID" value="XM_056930211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2I0"/>
    <dbReference type="GeneID" id="81620460"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22699">
        <property type="entry name" value="FHA_PLM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="99"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5495491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="505" mass="56116" checksum="902005DE851385FC" modified="2023-11-08" version="1">MDSSPALVRSASAAGVKRPAALLPAFEPLTSSPSLPRPSKRVARDNAYPTPVPTSSTHILSSSPPAARPLLRRTFSAATERSPLSAVPQVMLPENGEPVLMGRSSASCHHQLAASRMISRVHVKATYKPAPNPFDRDQVEIMCMGWNGIKIHCQGKTYDLAKGKTFTSDIKDADIMIDVHEARVLVQWPRHELDRKDCPSTDSEQTWDDGTPTQKNPHRRRHESPFLGGERLGSPDSPSPAVRNVIPPSSPIFTPSRGRGSVIVYEDEPSPLKRHNTVGGFSAYSARRASEMLQISQSSDVSRHHDESDNDEENDPIVHSFGPFGDNLLPRLASFHAGGSPSRSPAARRRSVTPVPRAHADSSRHIESSEEKEEVEVKTQEEEETFERVRNHAINQLAYSRLSSTPFSIILNNLPPSFWKSDKVANTSGPSRSDIRTILETTKCIGKVAREGKDAAGQPLESEFYYIPDFDEDIIRRETVVTNLRKPGLRNCRKQHKQYFWKKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C2J3</accession>
    <name>A0A9X0C2J3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Decapping enzyme Dcp1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_000245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794142.1">
        <property type="nucleotide sequence ID" value="XM_056929849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C2J3"/>
    <dbReference type="GeneID" id="81620098"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13182">
        <property type="entry name" value="EVH1-like_Dcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000444">
        <property type="entry name" value="Decapping enzyme Dcp1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010334">
        <property type="entry name" value="Dcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290:SF0">
        <property type="entry name" value="DECAPPING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290">
        <property type="entry name" value="TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06058">
        <property type="entry name" value="DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="347"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5495129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="50236" checksum="B8550D467C3F69A7" modified="2023-11-08" version="1">MRRMRQMPYFTNATAISRRYVISAIDMPLFCGREPRFKLGTSSLRSLLHTSLVINSPINPHALQLTNMATINAHKPRRTNNYSQSGSTTYPANNQLTDYESDAAYFSDLQQPQQQHQQLMQQQDPEHQSPPPPTRTNEEINLSVLRRHHSDIIAILSLAQYAVVYLFNPTSRQWEKTGVEGTLFVCQMTQGSLGEDRYTAFVLNRRGLNNFNLQLTDAENVELTEEYVILKADENAAGEMTETGRGSGGSAPGLRIYGIWIYSEPPPNSTAQARTVNAEKIRECAAHAGQSLKTAQERLEAIQQNGLHAAALLAENQVAPLEEVQASVAMGRQVSLKDLFGQQRAQDDGWSVRAHHEPQAQPLPHQQQQFQSQVAPQQRQQQYQEPVPPQQHSSQFYHNAPGYSVVPHQPQQTYQTPPPLPSAGQPGDVLGDLFRRAGFAYQAHDGQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C345</accession>
    <name>A0A9X0C345_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Microbial-type PARG catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_001252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5496136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056795149.1">
        <property type="nucleotide sequence ID" value="XM_056930856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C345"/>
    <dbReference type="GeneID" id="81621105"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02452">
        <property type="entry name" value="TIGR02452 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF1">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="PARG_cat_microb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microbial-type PARG catalytic" evidence="3">
        <location>
            <begin position="73"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="216"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5496136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="34309" checksum="EFF79E86C6CD7099" modified="2023-11-08" version="1">MSAYNARTKPWRYTTSQRPFPRNAKEDMNDTRRLTAWQAQPIAKDIIDAYEGTFGINFKFTWDDVPTLDSEETSSKHPGRINGTTVKVINKDTLDAAIALEAAEDILEVARKTRVLVLNFANATTPGGDWKAGATAQEEQIVYRTTLIHHGLDSKLYPLKAKEGVYTSNVLVLRENQNKGYFKMWIDRPECLPLISVVSVAAEASPALDLTRKKYAGAEQRERMENTMRSILRLAADHGHTRLVLGALGCGVFGHPPQEVADCWRRVLTAAEFKAWFDIIVFAVYDPANDTNFKTFHAILHDLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9X0C3A1</accession>
    <name>A0A9X0C3A1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5495985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056794998.1">
        <property type="nucleotide sequence ID" value="XM_056930705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9X0C3A1"/>
    <dbReference type="GeneID" id="81620954"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5495985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="119" mass="17940" checksum="BD7D4DB4E34432F2" modified="2023-11-08" version="1">MEFYCYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYFYYVYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYCQTLHSCQAAFCCADQPPSDRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKC1</accession>
    <name>A0A9W9WKC1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zinc finger CHCC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_009551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000019">
        <property type="protein sequence ID" value="KAJ5466595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785641.1">
        <property type="nucleotide sequence ID" value="XM_056939146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKC1"/>
    <dbReference type="GeneID" id="81629396"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.40:FF:000003">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="2">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5466595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="210" mass="23478" checksum="D7A6E225E5C4F1DC" modified="2023-11-08" version="1">MMSCSRRLTALTSVRSAAVRTYTSTVPRFENRMQPNDVNPPVVKPNVSETNAHLLTDRHEKWDGLMVEDPAKAERLRSLQAPNRATTWAASQQPREQAMVGPRFEQTIMETQPRPMAAIELIHKQPVRWTKSRVVSCDGGGGPLGHPKVFINTDKPEIVPCGYCGLPFAHEHHRSYLESLPATSYPLKSLGDPAEVNETQRVTDGSLEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKM2</accession>
    <name>A0A9W9WKM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_008858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785830.1">
        <property type="nucleotide sequence ID" value="XM_056938453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKM2"/>
    <dbReference type="GeneID" id="81628703"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5469240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="62" mass="7085" checksum="D08BA19467F042D0" modified="2023-11-08" version="1">MSSALQTRMLKSKLEVPRVRLQPRFVMNITPDISQVLAYLVTVVSKIAQSKNLAKHSKEYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WKW9</accession>
    <name>A0A9W9WKW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Self-sufficient cytochrome P450 monooxygenase CYP505E4</fullName>
            <ecNumber evidence="5">1.14.14.1</ecNumber>
            <ecNumber evidence="17">1.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Bifunctional cytochrome P450/NADPH--P450 reductase CYP505E4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">N7539_009012</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="29" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>dodecan-1-ol + reduced [NADPH--hemoprotein reductase] + O2 = 1,4-dodecanediol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76763"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:28878"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:195422"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:76764"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>dodecan-1-ol + reduced [NADPH--hemoprotein reductase] + O2 = 1,5-dodecanediol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76759"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:28878"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:195414"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:76760"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>dodecan-1-ol + reduced [NADPH--hemoprotein reductase] + O2 = 1,6-dodecanediol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76779"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:28878"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:195445"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:76780"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>dodecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 5-hydroxydodecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76723"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:195418"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:76724"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 26">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="27">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="5"/>
    <dbReference type="EC" id="1.6.2.4" evidence="17"/>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785984.1">
        <property type="nucleotide sequence ID" value="XM_056938607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WKW9"/>
    <dbReference type="GeneID" id="81628857"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000040">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF108">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="7 26 27" id="KW-0349">Heme</keyword>
    <keyword evidence="15 26 27" id="KW-0408">Iron</keyword>
    <keyword evidence="28" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 26 27" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 27" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="14 27" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="28" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="28" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="26">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00050670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00050725"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00052652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00069187"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00081991"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KAJ5469394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="465" mass="52105" checksum="8D075F62F75E4CC0" modified="2023-11-08" version="1">MAAEIPGPPGVPLLGNIFDITPGETWNSLSKLARQYGPIFKINALGHQIVFIGSVKLLEEICDETRFRKCVTGPVVEIRSAVHDSLFTAKHSEMKQWGIAHRIMAPYVSQEATDASFKDMAEVIPDLITKWTSGTQQKCLAADDLDRILLASCMKCFFNQRVHVLGTDAESNKAKKMVDAWESATMEALKRPTRPKLLNLVYSSRFSSLIKTMRSYATDIKNSRLNHPEQIRKDMLDAILNGVDPETGEKLTDSQHLDEIVTIFIGAATAANLVSWALYYLMQNPQPLRKAQEEIDRIVGDGPIALDHLTALNYVEACLREAIRLSATAPGFNIEPIPPADKKDKTPVLLGGGEWQIPNNQPMIAVLSSVNRDPEVFQHPEEFRPEQVYGEKWDLLPAAAKKGFGNGKRECIGKKWAWQWSFFTLASIIKDVAFELEDKDYKLHANGAFSTKPLDMWTLMSPRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL42</accession>
    <name>A0A9W9WL42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_009054</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786026.1">
        <property type="nucleotide sequence ID" value="XM_056938649.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81628899"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
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        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
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        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="312"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="361"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="446"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5469436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="535" mass="61146" checksum="8E80151DDFFEBDCF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WL92</accession>
    <name>A0A9W9WL92_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056785837.1">
        <property type="nucleotide sequence ID" value="XM_056938460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WL92"/>
    <dbReference type="GeneID" id="81628710"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF213">
        <property type="entry name" value="DEPENDENT OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="54"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5469247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="524" mass="56923" checksum="E2242B423B49D608" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLC8</accession>
    <name>A0A9W9WLC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_009145</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="SET DOMAIN PROTEINS"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="11">
        <location>
            <begin position="58"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="115"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="10">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="274"/>
            <end position="326"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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        </location>
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        </location>
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            <end position="299"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5469527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="504" mass="55702" checksum="BD289A02A6982FB5" modified="2023-11-08" version="1">MPMFGGSRMIENGRDYVLPFDVFSPLPPGQPKPDEWRKTNKNVFVGDAASEWKANKKLELSTCMCEEDTGCDENCQNRYMFYECDSGNCRLGPECGNRNFSELKHRTKAGGKYNIGVEVIKTSDRGYGVRSNRTFEPNQIIVEYTGEIITQFECERRMRTVYKKNEVGFPLLFHFSYECLPNFSLQCYYLMYFDQNMIIDATRGSIARFVNHSCEPNCRMEKWTVAGKPRMALFAGDRGIMTGEELSYDYNFDPYSLKNVQQCRCGSENCRGILGPRPKDKDQRAKMEEKAQAEKEVKKPAGKKRKLADAESADSQKGKKRKILNAKSIKAGVKKVVAKATARGKTGSKKTVKSATTTKSKAKKTVTLPKVKVASRVKATVANASQSKGKAAKTKVTAASSSKGSSVLKRPSLETKKKILARAKGTGRASPKKSPAKIKKGDAKSPRKPAGKKAAAKSPVKPRVPPSKVKKNGTGFGTKAQRTIKGSVKKATKSVVRTIKGKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WLI7</accession>
    <name>A0A9W9WLI7_9EURO</name>
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        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_009235</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000015">
        <property type="protein sequence ID" value="KAJ5469617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786207.1">
        <property type="nucleotide sequence ID" value="XM_056938830.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="81629080"/>
    <dbReference type="Proteomes" id="UP001148312">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5469617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="680" mass="77377" checksum="498AFE7255BF933D" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WTJ4</accession>
    <name>A0A9W9WTJ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_008177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
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                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000012">
        <property type="protein sequence ID" value="KAJ5475111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056786869.1">
        <property type="nucleotide sequence ID" value="XM_056937777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WTJ4"/>
    <dbReference type="GeneID" id="81628027"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
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</entry>
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            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="880" mass="96750" checksum="5EB7502DE50926DF" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WUB8</accession>
    <name>A0A9W9WUB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_007926</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JAPWDQ010000011">
        <property type="protein sequence ID" value="KAJ5475639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787392.1">
        <property type="nucleotide sequence ID" value="XM_056937527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WUB8"/>
    <dbReference type="GeneID" id="81627776"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF16">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041019001" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="24"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5475639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="584" mass="64156" checksum="E05C4D61EB37DA03" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WV53</accession>
    <name>A0A9W9WV53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pentatricopeptide repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_007442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787842.1">
        <property type="nucleotide sequence ID" value="XM_056937043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WV53"/>
    <dbReference type="GeneID" id="81627292"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5477298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="826" mass="94136" checksum="97454279156C99CB" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVD3</accession>
    <name>A0A9W9WVD3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Prenyltransferase alpha-alpha toroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_007356</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787756.1">
        <property type="nucleotide sequence ID" value="XM_056936957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVD3"/>
    <dbReference type="GeneID" id="81627206"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF4">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="6"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="286"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5477212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="467" mass="52089" checksum="14D3113F1E6AFAA0" modified="2023-11-08" version="1">MAAPIFNTERHVKYYLRCLKTFLPSAYTSNDSNRMLLAYLTLGGLDVLGVLHSKTTPEERQGYIDWLYHCQVPSGGFRGFPGTDFGDERRTSENEAWDPANIPATFFALVNLLMLGDDLSRVKRKECLEWLPKLQRADGSFGETIGVRGAIEGNRDLRYCCCASGIRYMLRGPYGKGVEEVKDIDVARLISFIEQCQNYDGGMGESPFRESHSDLGGHTYCAVGSLHFLRRGTDKSRSSLLLCPGSKSFESLVHWLASRQTNKLLGEGDEDEVNEDDIEEEQEEEAAAAEEENMIKCDEETPESVVGMQSHRQKERPVDEGHQEVKSTSNSTEDEIRGLSYLTPESGEGMACAGFNGRCNKLADTCYSFWNGAALMMLDRYSVIDDVRNRQYLLGKTQHLVGGFGKGVGDSPDLLHSYFGLVSLAFQGEEGLTRVEPALVATDRTVAHLESLPWWSFTTDKVEISEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9WVQ3</accession>
    <name>A0A9W9WVQ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_007544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000010">
        <property type="protein sequence ID" value="KAJ5477400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056787944.1">
        <property type="nucleotide sequence ID" value="XM_056937145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9WVQ3"/>
    <dbReference type="GeneID" id="81627394"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5477400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="69" mass="7641" checksum="295A75803B54CDD9" modified="2023-11-08" version="1">MMLVVVVAATRRKRLGESVKREQELVTDAIGGGESNAEDSQEETEEVPRPKEMEKRLVGGGWTRTGQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1R8</accession>
    <name>A0A9W9X1R8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_006672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788208.1">
        <property type="nucleotide sequence ID" value="XM_056936273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1R8"/>
    <dbReference type="GeneID" id="81626522"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5480778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="266" mass="29485" checksum="594444CD1A6511EB" modified="2023-11-08" version="1">MQILIHPRLRTTLPRALRRDFQAQVWARHKSQALRPSRRHEAVAPAPKDLTAATTSRTSSPAGAAAAAKLSVRRGPPERILVYYGGTGRSMFLGILRVTTILLFGGACLIVAPSCYDDENAWYITPLVVAGGALPMLFVAYTSAPYVSFIHLALPAFARKSRETALHFAKDLPPTTSLILTTTRFNAIPRQTVVRLGDLIPDKSALRPVTFRTLNPAPRPWWMGKPVTQFFAADKSQPGRQSTAFYPELWPGIYKQIQSQASRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1Z1</accession>
    <name>A0A9W9X1Z1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thymidylate synthase</fullName>
            <ecNumber evidence="4">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">N7539_006793</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788329.1">
        <property type="nucleotide sequence ID" value="XM_056936394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X1Z1"/>
    <dbReference type="GeneID" id="81626643"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000005">
        <property type="entry name" value="Thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5480899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="337" mass="37588" checksum="8AD69054A3013B99" modified="2023-11-08" version="1">MTQDQPGPLADSKPVAHHDPSHEEHQYLNLIRTILDNGEHRPDRTGTGTRSIFAPPQLRFSLSKPDPNGGDPIKVLPLLTTKRVFLRAVLAELLWFIAGSTSSLPLSEAGIKIWDGNGSREFLDKVGLGHRAEGDLGPVYGFQWRHFGAEYVDAQADYTGQGVDQLKEVVVKIMNSPFDRRIIMSAWNPADLKKMALPPCHMFAQFYVSFPPSMKLDEETGKPNEKGTLSCLLYQRSCDMGLGVPFNIASYALLTHILAHAADLHPGTLIHTMGDAHVYLDHVDALNEQLTREPTEFPELVIKRDDRGSAVIDGWKEDEFEVVGYKPHKTIKMKMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X1Z7</accession>
    <name>A0A9W9X1Z7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">N7539_006878</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5480984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788414.1">
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    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="term" value="P:DNA damage checkpoint signaling"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Inositol kinase kinase (UvsB)"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
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    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="DDR_Repair_Kinase"/>
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        <property type="entry name" value="HEAT_ATR"/>
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    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
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    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
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    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012993">
        <property type="entry name" value="UME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF125">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00802">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FAT"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PI3_4_KINASE_2"/>
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    </dbReference>
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        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="18">
        <location>
            <begin position="1463"/>
            <end position="2041"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="17">
        <location>
            <begin position="2155"/>
            <end position="2490"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="19">
        <location>
            <begin position="2458"/>
            <end position="2490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="437"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ5480984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="2490" mass="279131" checksum="8BFA0865EB8F0A54" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2L2</accession>
    <name>A0A9W9X2L2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_006164</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788690.1">
        <property type="nucleotide sequence ID" value="XM_056935766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2L2"/>
    <dbReference type="GeneID" id="81626015"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000086">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000085">
        <property type="entry name" value="Glycerol kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 10 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="12">
        <location>
            <begin position="56"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="13">
        <location>
            <begin position="320"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5482718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="569" mass="63218" checksum="95239A2E22B79BBD" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2R1</accession>
    <name>A0A9W9X2R1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 13">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_007074</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Endoplasmic reticulum membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 13"/>
    <dbReference type="EMBL" id="JAPWDQ010000009">
        <property type="protein sequence ID" value="KAJ5481180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788610.1">
        <property type="nucleotide sequence ID" value="XM_056936675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2R1"/>
    <dbReference type="GeneID" id="81626924"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF24">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5481180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="213" mass="24055" checksum="828432D6B0E4C575" modified="2023-11-08" version="1">MSASDKSQARKLSSVSQTYLLAYNVLCAIVWLRVLTGVISELISSGRSTDVYASLEPWTRYAQTLAAAEVLHAIFGITRSPVFTTFTQAFARSTQVWAVNYAFPRTTSVSYAYPAMILAWSMADVVRYSYFAVMLAGKTNSGVLRWLRYSLFVVLYPVGISSEWWLMYKSTTVTDCNALIALYYFFLALYGPGSVMMYKYMLKQRKKVLARAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X2X0</accession>
    <name>A0A9W9X2X0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_006197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788723.1">
        <property type="nucleotide sequence ID" value="XM_056935799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X2X0"/>
    <dbReference type="GeneID" id="81626048"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5482751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="87" mass="9431" checksum="F5888190446CE316" modified="2023-11-08" version="1">MSDIAFFCFALQKSRPSKSDIANLTRAQAITRVLELLPLSKSWPSSRAQLSIFRYGTSLSTSAKESNLINSTGSAACIVTRSMIADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X366</accession>
    <name>A0A9W9X366_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_006460</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5483014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788986.1">
        <property type="nucleotide sequence ID" value="XM_056936062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X366"/>
    <dbReference type="GeneID" id="81626311"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF55">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041012839" description="Transmembrane 9 superfamily member" evidence="9">
        <location>
            <begin position="27"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="596"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="633"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="669"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="337"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5483014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="725" mass="81075" checksum="51E80D4A0E550D33" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X470</accession>
    <name>A0A9W9X470_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_006360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JAPWDQ010000008">
        <property type="protein sequence ID" value="KAJ5482914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056788886.1">
        <property type="nucleotide sequence ID" value="XM_056935962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X470"/>
    <dbReference type="GeneID" id="81626211"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF29">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="8">
        <location>
            <begin position="18"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="9">
        <location>
            <begin position="249"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="448"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5482914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="582" mass="63861" checksum="459650A4108ABCA3" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5A0</accession>
    <name>A0A9W9X5A0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_005939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789413.1">
        <property type="nucleotide sequence ID" value="XM_056935541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5A0"/>
    <dbReference type="GeneID" id="81625790"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5484143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="87" mass="9809" checksum="A2B4CDD02F8DA9A7" modified="2023-11-08" version="1">MRRPGYLFNGGYVTMCVTFVRHPAGLDAPASPEASSNMTEKKRKLRLGIRSQRENVTRVKETLESFNGTEEFGSTDHERLAWAGSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5A2</accession>
    <name>A0A9W9X5A2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Beta-glucan synthesis-associated protein KRE6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">N7539_005890</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000006">
        <property type="protein sequence ID" value="KAJ5484094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789364.1">
        <property type="nucleotide sequence ID" value="XM_056935492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5A2"/>
    <dbReference type="GeneID" id="81625741"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="13">
        <location>
            <begin position="250"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5484094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="667" mass="74394" checksum="A7DA52B8ED869FFD" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5L4</accession>
    <name>A0A9W9X5L4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Prion formation protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_004851</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789647.1">
        <property type="nucleotide sequence ID" value="XM_056934453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5L4"/>
    <dbReference type="GeneID" id="81624702"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0034">Amyloid</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0640">Prion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="484"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="728"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1039"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1065"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1047"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5484863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1124" mass="122250" checksum="A7BDD057030F7E61" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X5R0</accession>
    <name>A0A9W9X5R0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome assembly chaperone 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_004926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789722.1">
        <property type="nucleotide sequence ID" value="XM_056934528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X5R0"/>
    <dbReference type="GeneID" id="81624777"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018788">
        <property type="entry name" value="Proteasome_assmbl_chp_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5484938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13170" checksum="AE24BB21F9B94614" modified="2023-11-08" version="1">MASTRGPWGEHLNLPFPAATKQVAGHVEGVKTDVMVVSFSDKIMLTVSQEGRLSHWPDGNINSGGYGAGQDTLGQLLARQIATAIAVKSPSEKRLLVVGLGLRNANLERDSFFAIIDLVLQCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X601</accession>
    <name>A0A9W9X601_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LAA1-like C-terminal TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_004915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5484927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056789711.1">
        <property type="nucleotide sequence ID" value="XM_056934517.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81624766"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000745">
        <property type="entry name" value="Chromosome 7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000645">
        <property type="entry name" value="HEAT repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000886">
        <property type="entry name" value="HEAT repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057981">
        <property type="entry name" value="TPR_LAA1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25468">
        <property type="entry name" value="HEAT_HEATR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25808">
        <property type="entry name" value="TPR_LAA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAA1-like C-terminal TPR repeats" evidence="3">
        <location>
            <begin position="1882"/>
            <end position="2049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1578"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1582"/>
            <end position="1601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5484927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="2068" mass="226227" checksum="62C9741AD2954D3C" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6K8</accession>
    <name>A0A9W9X6K8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">N7539_005220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790016.1">
        <property type="nucleotide sequence ID" value="XM_056934822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6K8"/>
    <dbReference type="GeneID" id="81625071"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
            <begin position="127"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="394"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5485232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="450" mass="51061" checksum="B686FDEC2084736F" modified="2023-11-08" version="1">MAKETTIAPPVAELNVYVSSPSGPRPAKETTFREWVVSNQIGISLTILAMLLALHNLYPSLRPYTQPFFELSYHDPATNTYVQGWNDIYFVFSATLALTAVRAIVIEWILQPVGRSLGLKRKAALRLAEQGWQVLYYGFIWSVGLYLWKNSNYWCDFSTIWNDWPARPVDGLMKWYILVELAFLLQQIFVIHVEEKRKDHYQMLSHHIITSTLLGSAYIYGFYNVSNVVLCLMDIVDVLLPAAKVLKYLKFQNACNVAFGIFMATWVVTRHVLYNMLWWSIYKNVPQQMAYGCYSGETAEMISTNGYPDAFAYLFGPFLSLKNPICMNRTIKWIFLSFLLSIQLLSIVWFSMIVRVAYRVVCSGAAEDTRSDEEDEVEMDEDSTHSGTVRLAAKENGNAAPAVVNENAPGLDRRRSNGSAAARARGRGRVPFDQSDRKALLGRIGCDKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X6T7</accession>
    <name>A0A9W9X6T7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aromatic-L-amino-acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">N7539_005526</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IBT 30728</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790322.1">
        <property type="nucleotide sequence ID" value="XM_056935128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X6T7"/>
    <dbReference type="GeneID" id="81625377"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5485538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="522" mass="58236" checksum="5873B70FA0D057C0" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X710</accession>
    <name>A0A9W9X710_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_005302</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790098.1">
        <property type="nucleotide sequence ID" value="XM_056934904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X710"/>
    <dbReference type="GeneID" id="81625153"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000001">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1760:FF:000005">
        <property type="entry name" value="Putative alpha-glucosidase AgdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000138">
        <property type="entry name" value="Putative alpha-glucosidase AgdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000169">
        <property type="entry name" value="Putative alpha-glucosidase AgdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040784440" description="alpha-glucosidase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="10">
        <location>
            <begin position="323"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="11">
        <location>
            <begin position="761"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5485314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="983" mass="108327" checksum="179E6E2E88E04EFA" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7S7</accession>
    <name>A0A9W9X7S7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear speckle splicing regulatory protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">N7539_005654</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790450.1">
        <property type="nucleotide sequence ID" value="XM_056935256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9X7S7"/>
    <dbReference type="GeneID" id="81625505"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053246">
        <property type="entry name" value="NS_splicing_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018612">
        <property type="entry name" value="NSRP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845:SF1">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09745">
        <property type="entry name" value="NSRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear speckle splicing regulatory protein 1 N-terminal" evidence="4">
        <location>
            <begin position="143"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="274"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="343"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="411"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5485666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="448" mass="49643" checksum="B63E51C99CFCDB62" modified="2023-11-08" version="1">MARPFSAGLNMAIKQSAGLKPGEKRKKNIFDDDSADEGEAQDGTIEVSTIGGLDASPQLSTQFTNGGPPPKPKMQLGFTAKSAPKPLKKPSLFDNDEEEEEAREKQRQEEVQFGLNEPQSKKKKTTSGPENDLTNLSALHSSKKHSKEAEELDPSIYSYDAVYDSLHSKSNKTATVNKSEAPKYMTNLLRSAEIRKRDQTRARDRQLAKEREAEGDEFADKESFVTGAYKAQQEELRKMEEEEKRRELEEEERRKKNGGVGMVGFYRDVLSRGEAQHEEAVKAAEEAARRVKAGEAVEDETKASDEKSEAQIAEELKARGARIAINDEGQVVDKRQLLSAGLNVAPKPKAAPSTQRAAEVRSGGGRPSGIHAGHQTGRAAQRTRQTEMIAQQLEEQARRDEEAEALRQKEIAEKVRSRKTATDVSSAKERYLARKREREEAAAKGKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9X7V6</accession>
    <name>A0A9W9X7V6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">N7539_005278</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IBT 30728</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 16">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="EMBL" id="JAPWDQ010000005">
        <property type="protein sequence ID" value="KAJ5485290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790074.1">
        <property type="nucleotide sequence ID" value="XM_056934880.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81625129"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF174">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1291"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1341"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1375"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1404"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1451"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="247"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="19">
        <location>
            <begin position="1227"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="858"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="928"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1569"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="877"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="890"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="928"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="958"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1569"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1602"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="624"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="624"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="624"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="625"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="626"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="626"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="765"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="813"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="836"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ5485290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1645" mass="184273" checksum="7AFA44611B053681" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XC73</accession>
    <name>A0A9W9XC73_9EURO</name>
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        <recommendedName>
            <fullName evidence="2">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">N7539_003614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5488724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056790757.1">
        <property type="nucleotide sequence ID" value="XM_056933216.1"/>
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    <dbReference type="GeneID" id="81623465"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DUF7923"/>
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    <dbReference type="InterPro" id="IPR057654">
        <property type="entry name" value="Znf-CCCH_tandem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25543">
        <property type="entry name" value="zf-CCCH_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="2">
        <location>
            <begin position="369"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="2">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="369"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5488724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="467" mass="52981" checksum="793162B7E50B19A8" modified="2023-11-08" version="1">MTSSPYFERYRQLKAVDQQKNQLIEDLLQRVSDLETSFAQEKLDHERETRFNRDIQVHEMELMQQIAQIKIIMDREPFVVVLLDGEGMIFKDEFLQAGDKGGRCAADQLYGAIHSYLKANLPNVSTPKIMMKIYLDAKGFGELCARNRVFADPAAIYDFIRGFNETMSCSEIVDVGSGKNSAYNKIQESFQVFLYNCHCHQIFVGCPSNTEYALFLEDISRDNDLTGRVSLIEGVAFEKDLDEVKASYRIARFPDLFRSEKMVPACAPTPWKPSLPTRSILTPSPSAQFSSMVNAPVLSRTSTNTSTSGVPLSASTPVQQDSAFEFQKVVRSKPSSSAPPPKTVERNKYGQRVDKLDFKSIPRDDLNRLKKLKLCNYYFLLGECPNDDYCYHDHDRKLTKEELHILTAIARMTPCRFGLECDDAECIYGHRCPQSEPGKKTCFRGDSCRFEPIAHGIDTNVVKVTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XD94</accession>
    <name>A0A9W9XD94_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_004106</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791249.1">
        <property type="nucleotide sequence ID" value="XM_056933708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XD94"/>
    <dbReference type="GeneID" id="81623957"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5489216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="445" mass="49955" checksum="AA6128C8E3DA5E6D" modified="2023-11-08" version="1" fragment="single">GRGASSQVLHAVSVQQRLTFSMSARPFRSRRSHQKSRHGCAECKRRRIKCDETTPVCTNCGNRGQECSFASVSPANSTISSGSPSSGTPRGQDPQARRFEPRVFSNGGRQQTFRLATSKRGQRAPRNEPADSPAESSLSDGISIADLRLFHHYSISTCFTLTEDNDPNGVMQKHIAQWGMDFPSILHLILALAAWHLAYLTPESRNSYISQAENHFTSGVRIVTRELANFNVDNCQKIYMSAVLVCLAYFARGPQPGEYLIFSDSGISEWQRLLRGVKVIVTTYRHEVFSGVLAPGEGGESGAMSESLCVELREHTKEVKTLGQFVMQNINTQPNRSMYQSAIDDLLMIMQDVYKKLVVNDPGVGLMPSLMGWLYRLPDEFVCLLEQKEPFSLMILSHWAVILRYMESVWFMEGWSQHVLRGISANLSADFQPHISWPIQRITEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDF9</accession>
    <name>A0A9W9XDF9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791036.1">
        <property type="nucleotide sequence ID" value="XM_056933495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDF9"/>
    <dbReference type="GeneID" id="81623744"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="96" mass="11129" checksum="B46C719314117A66" modified="2023-11-08" version="1">MNSTYYDPANTPRSLSKRDGEETADEEEPDFWAHAAPANPWMRGHRTRQNNLTTLDALRENELYREPVLRARSSYDGLAFYRVLGWRSENVEALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XDK3</accession>
    <name>A0A9W9XDK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_004300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791443.1">
        <property type="nucleotide sequence ID" value="XM_056933902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XDK3"/>
    <dbReference type="GeneID" id="81624151"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5489410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="242" mass="27985" checksum="70219E5300911396" modified="2023-11-08" version="1">MSCFQTVGYLLERKHCFLESPEWKTLPWAKCGLDAKLPIEELQDLLCDLPGQLEDVDKILTWEKDELSKAALHSALCSRIFATLSKPFTLADGSGSRCFRVAHTWLSPCDLVHRPIPCPRFDDIQHHSVDCYTDHLKRSACMLATRCPIDLKMTPFFLWKGQETKWLLKYCRMVDYHMHSLRRSSGAFMLIFPLNVAHLHLDQDTGEIKTWLEAVMAVVADYHGFEVGRRENMPRQLHPSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XE07</accession>
    <name>A0A9W9XE07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">MICOS complex subunit MIC12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Altered inheritance of mitochondria protein 5, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Found in mitochondrial proteome protein 51</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_004550</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MICOS complex subunit Mic12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791693.1">
        <property type="nucleotide sequence ID" value="XM_056934152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XE07"/>
    <dbReference type="GeneID" id="81624401"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031463">
        <property type="entry name" value="Mic12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17050">
        <property type="entry name" value="AIM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5489660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="124" mass="14404" checksum="EC3E427E9123442B" modified="2023-11-08" version="1">MNFVSGFAGGFALTTSVLYITITKHRATRLEQRRQIREQVHQINWLAASAGAYDRRFLPQHKPRSIETTKRPEETQITIKDVLKHRWNQEVGNFARNANGNRWEVVKNAASRGWNDILQFVKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XEN0</accession>
    <name>A0A9W9XEN0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_004227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000004">
        <property type="protein sequence ID" value="KAJ5489337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056791370.1">
        <property type="nucleotide sequence ID" value="XM_056933829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XEN0"/>
    <dbReference type="GeneID" id="81624078"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5489337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="213" mass="23428" checksum="E556C4711257A439" modified="2023-11-08" version="1">MTSEQPSPFPPGLPITTQRLCIQPFDPENLTHCKFLAQLWNTDDFINSCGKTSIDSPEKAAAFIRRRILADYAQNRHGQFLVSRLEENDPAKLIGCVSLMKGSPPGPHYLAPDIGFTILPEESGKGFASEAARELIDWARRELDIHAVFGFCAPDNARSRRVLEKSGLEYRGSAALRVFGDQVSAIYALPDMDSDLGVYNMTEEVHGAASEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XES4</accession>
    <name>A0A9W9XES4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Pentafunctional AROM polypeptide</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate synthase</fullName>
                <shortName evidence="21">DHQS</shortName>
                <ecNumber evidence="21">4.2.3.4</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
                <ecNumber evidence="21">2.5.1.19</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="21">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
                <shortName evidence="21">EPSP synthase</shortName>
                <shortName evidence="21">EPSPS</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate kinase</fullName>
                <shortName evidence="21">SK</shortName>
                <ecNumber evidence="21">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate dehydratase</fullName>
                <shortName evidence="21">3-dehydroquinase</shortName>
                <ecNumber evidence="21">4.2.1.10</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate dehydrogenase</fullName>
                <ecNumber evidence="21">1.1.1.25</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="28" type="ORF">N7539_002463</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20 21 22">The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:21257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 21 22">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21 22">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21 22">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21 22">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 21 22">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 2nd section; belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 3rd section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 4th section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the C-terminal section; belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the N-terminal section; belongs to the dehydroquinate synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="21"/>
    <dbReference type="EC" id="2.5.1.19" evidence="21"/>
    <dbReference type="EC" id="2.7.1.71" evidence="21"/>
    <dbReference type="EC" id="4.2.1.10" evidence="21"/>
    <dbReference type="EC" id="1.1.1.25" evidence="21"/>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5490896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792025.1">
        <property type="nucleotide sequence ID" value="XM_056932066.1"/>
    </dbReference>
    <dbReference type="GeneID" id="81622315"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
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            <name>Zn(2+)</name>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00054455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRNR" id="PIRNR000514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KAJ5490896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="1583" mass="171521" checksum="A97B86CFD89B9AAD" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XF50</accession>
    <name>A0A9W9XF50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-inducible SAM-dependent methyltransferase Rrg1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_002611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792173.1">
        <property type="nucleotide sequence ID" value="XM_056932214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XF50"/>
    <dbReference type="GeneID" id="81622463"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF156">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5491044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="39157" checksum="C6023B47728DBCF2" modified="2023-11-08" version="1">MIVPVGDEPIHVLDLPQIYQKPSGTDLLKTLALLTLQPRTFGTSAEAVKGPSVQPAGVTRYLTQIVSSSLSWLETDELREAVWDAAGARLSERSGRAVDRSLIDNLLNLPTAMPAMSRIFSIPTATGEDLTLTLHEPSLTEDNLGMKTWVSSYLLSRRLHSLYTTPPSLVSSELAEPSSKTRTKALELGSGTGLVGLSFAALMGESAVVHLTDLPEIVPNLAHNVALNVELLSSAKADVTTGLLDWSVKPDPLPAADERYDVILAADPLYSPKHPKWLVDTIESWLSKRLEARVVAEMPLRDAYLPQVQEFRQRMTDMGLTVVDEGEEVGYDDWESSEGDALAVKCWWSVWGWSERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFB9</accession>
    <name>A0A9W9XFB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_002772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792334.1">
        <property type="nucleotide sequence ID" value="XM_056932375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFB9"/>
    <dbReference type="GeneID" id="81622624"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="223" mass="23422" checksum="E33E31A37EF6E1E0" modified="2023-11-08" version="1">MSMNSLFLQQNCDYSLKHCNWLGVEGGNCAQKFCFGGTYDPSVLDDNASECVASGSAAHPTYYPYASVMSGFCSNVAGPASTPATMTMTDGQTGSPANATPNPTAGNATMRPATDTSGVGPTSSAASSSQLVCSVHSVSSSSTDPYHSMGSMVANPYTEDISGISPASLEIVSLGALRIVFDGFRKRIDETDGFVRKSAEHALRRYFSSERSHPDILTKLSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFI5</accession>
    <name>A0A9W9XFI5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_002774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792336.1">
        <property type="nucleotide sequence ID" value="XM_056932377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFI5"/>
    <dbReference type="GeneID" id="81622626"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5491207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="108" mass="11317" checksum="5DC4B5879EEA3D32" modified="2023-11-08" version="1">MERTFNSTVYAIAYGGPNAPACDHFSAEVVTGQTSIPGQCVSVADSYSMWVTRLAHNCVPYAYAQENCNGTSRKLGGISPPDCVVAAAAGDLAGKSGESFRSFQILCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XFN8</accession>
    <name>A0A9W9XFN8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">N7539_002943</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792505.1">
        <property type="nucleotide sequence ID" value="XM_056932546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XFN8"/>
    <dbReference type="GeneID" id="81622795"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="99"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5491376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="357" mass="39619" checksum="0056C961C0F154DD" modified="2023-11-08" version="1">MLHYRTQGFNGSAVKYSPFFDNRLAVASAANFGLVGNGRLYVLELTANGIVPVKWFTTQDSLYDLAWSEIHENQVLTASGDGSIKLYDTTADDFPIMNWKEHNREVFSVNWNLVAKDRFCSSSWDGTVRVWTPHRQQSLLTLPTHSCTYSVSFCPHNPELISCVTSDSYVRLFDLRTPASASNHLVAQIPNHAAPMPPPIPSQPGLPPAATQPAEILTHDWNKYRPTVLATAGVDRAIRTFDIRAPQQGPLSIMLGHDYAVKKLAWSPHLSNVLLSASYDMTCRVWDDRSEATGAADVDPMRSGPVSPVAGSELGRMGRHTEFVTGVDWCMFGNEGWCASVGWDENLYVWDVRAIMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XG09</accession>
    <name>A0A9W9XG09_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_003123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000003">
        <property type="protein sequence ID" value="KAJ5491556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056792685.1">
        <property type="nucleotide sequence ID" value="XM_056932726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XG09"/>
    <dbReference type="GeneID" id="81622975"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5491556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="354" mass="38874" checksum="50CD3132561ECBA7" modified="2023-11-08" version="1">MIRSQLRQIASHGDRAWMGMTAMPIRQFSVSHVAAAEGPAKPTQPRGEPRQRPAPTGPPRKPRPSSRPAPSSSTGMAKGSGAGNTFKPRPARAIDARSLAAAPRTGGEPPKIIRRPRPRTGPPGKPMLGRKGKLGAKGAQKPRRTKKTRRSAEDFDEDESVAAAIKKAEDERELKMRPVPVPYEPKQIDFAALKETWPALPTTTHARSAAIIERLSTLSGRFPGGYVPPHELGRRLYKGQSVLFETEAEKTEALEEVKRLAQARADKVSQRKGEPIEPRDIKFSAVSQEHTQALMETYVQGKYPTVEIGKDQPAVMGEVLRNLRNNSTYQTAGKRPQFLAKVESLLASSRVKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XGS2</accession>
    <name>A0A9W9XGS2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_001442</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793076.1">
        <property type="nucleotide sequence ID" value="XM_056931045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XGS2"/>
    <dbReference type="GeneID" id="81621294"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="8">
        <location>
            <begin position="100"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5492696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="359" mass="40772" checksum="8BD04B0B02BB8064" modified="2023-11-08" version="1">MDVTQQSYGIRELYRPDNEEIEIDIVAVHGLNGHVTETWTSKPQGTCWLSNPAYLPKYIPRARVLAWGYNASIASWNAKTPSADRVLQHAQTLVSQLESDRDLEDATKRPIIFVCHSLGGIIVKRALAYAESRPRLAHVHSIYTCTFAILFFGTPHHGSNKANLLGSLQKMASLTIPKTVVEFESGLVNALEKESEILQNITDQFAPLMPNFRVFFFWEQEKTNLKYRRDYIVDETSAAPILDNTERCGIGADHQRMCKFQSPNDQGYRTAVAALRRYAREAPYVIQRRYQRAANMYRDDRLVEAEELLGTVQTAVPGPRQSALHYLDTANTVVRTQIDDSQPTSQPRLNQKKTIYLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH11</accession>
    <name>A0A9W9XH11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_001573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5492827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793207.1">
        <property type="nucleotide sequence ID" value="XM_056931176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XH11"/>
    <dbReference type="GeneID" id="81621425"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5492827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="73" mass="9230" checksum="23ECC26DF049A8CA" modified="2023-11-08" version="1">MVHSTVAEEGPSHSQEDRHPRSGVLLRKELSHSIDVSREPPGFIERGQKTHYYYYYHYYYYYYYYYYYYYYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XH98</accession>
    <name>A0A9W9XH98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">N7539_003154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Sorensen T."/>
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</entry>
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</entry>
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</entry>
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    <comment type="caution">
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            <dbReference type="EMBL" id="KAJ5493161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="424" mass="46683" checksum="4CB5A65BAD132E62" modified="2023-11-08" version="1">MKGTSLLSFKSWTKIHQPLPRTPRESQQLLNALTSSFRRQLDRTYPSPSPSERPTSDRPSLNSTSSAHATDQHLHSILDNPLFRIVPQKTPIIARSQNCAPSTRCPDTLAQDPMVLFDQAFAAGTATPVFITDCLKSQLLLARSSGEEGLPAAMKLTRAGSKVANWFWASDGASRRSLLQNRASTGSLAKFMVAEGLQETVLEWLKMLLTGDLGGLNGSLTPDQARLMFNHLLQDLLDAEIRYGAGVGSAITYYLRARSLQVLSADVHGDLKAAKTLLLAPGAQLARALGELKPSPAQLSVHIFDEFAGIISTLSSSRSLLYSSVALCHPSHPDPTPFIHYVDSLSPKKFQKWSDTRQDAFLRVSCDALRALIDRKKIRLATNLGHQIQELLPEETASASVEVSRSRVTEEEDYLLRRLNMSWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHV5</accession>
    <name>A0A9W9XHV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ADIPOR-like receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">N7539_001930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793564.1">
        <property type="nucleotide sequence ID" value="XM_056931533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHV5"/>
    <dbReference type="GeneID" id="81621782"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5493184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="319" mass="35440" checksum="2CA648C8F10DB9EB" modified="2023-11-08" version="1">MSRQRRAAHGAESHSESRGSTSADSVLDSAAATMSRLVHWNDLPHWQRDNQHIHTGYRPASSSFQKSFHSLSYLHNESVNIYTHLIPSIAAIPAGYQLYQALAPRYESADEADIVAFACFFAGAAFCLGMSATYHTISNHSPRVARIGNALDYIGIVGLIVGSFIPSIFYGFYCNPALQHRYWTMICTIGFACMCVSIIPQFRTPRWRPFRAAMFVGMGLSAILPVLHGLGLFGYERMRQQIGLEWLLLQGFLYILGAGIYAARVPERLRPGQFDLFGHSHQIFHVLVVCAAVAHLTGLLKAFDYRHSGIAEACQTLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XHW2</accession>
    <name>A0A9W9XHW2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">N7539_002054</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IBT 30728</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793688.1">
        <property type="nucleotide sequence ID" value="XM_056931657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XHW2"/>
    <dbReference type="GeneID" id="81621906"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032126">
        <property type="term" value="C:eisosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052649">
        <property type="entry name" value="NCE102-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165:SF1">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="7"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5493308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="172" mass="18848" checksum="DA395477D0F00DA8" modified="2023-11-08" version="1">MGLNIVQTGLRVWQFIWTLLIMALVGNMIDTAMAGNPSVVNYTMFVVAFSMFSLFYLFPASFNPDWAISPIIMIVVDALNMIFFFCAAVALPSYLHVHSCSNAGYLASNSITNGSFDMEKRCREAQASTAFLWFAWAGYLASLIISILMSRSAGSKLGSGGGSRRRPNMAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XI86</accession>
    <name>A0A9W9XI86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">N7539_002218</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793852.1">
        <property type="nucleotide sequence ID" value="XM_056931821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XI86"/>
    <dbReference type="GeneID" id="81622070"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5493472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="231" mass="25696" checksum="50A977BA85D4C0C2" modified="2023-11-08" version="1">MASLRANCRKVMCIGRNYADHIAELNNTAPKQPFFFLKPSSSILPPNSGPVLRPKGVNLHYEVELGLVMGKTVRDLDPQDEQGALDAIESYVLAIDMTGRNVQDEAKKKGLPWSIAKGFDTFMPISQVIPKSRLPNPHDAFLRLRVNETEKQADSTGLMLYRIPQQLAHISRIMTLEKGDIVLTGTPKGVGQVKAGDMMHASIEVDGQEIEEGRIQVEVQDRQGPYEFKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XIA4</accession>
    <name>A0A9W9XIA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Arabinanolytic transcriptional activator araR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">N7539_002248</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IBT 30728</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Transcriptional activator of the arabinanolytic system. Involved in the regulation of extracellular arabinanolytic genes and in the regulation of the intracellular activities of L-arabinose catabolic genes in the pentose catabolic pathway (PCP) in response to the presence of L-arabinose.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the xlnR/xlr1 family. araR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793882.1">
        <property type="nucleotide sequence ID" value="XM_056931851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XIA4"/>
    <dbReference type="GeneID" id="81622100"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000031">
        <property type="entry name" value="C6 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF2">
        <property type="entry name" value="ARABINOLYTIC TRANSCRIPTIONAL ACTIVATOR ARAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="146"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="221"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5493502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="854" mass="95265" checksum="50835E271A03A5E0" modified="2023-11-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XII9</accession>
    <name>A0A9W9XII9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">N7539_001991</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IBT 30728</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000002">
        <property type="protein sequence ID" value="KAJ5493245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056793625.1">
        <property type="nucleotide sequence ID" value="XM_056931594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9W9XII9"/>
    <dbReference type="GeneID" id="81621843"/>
    <dbReference type="Proteomes" id="UP001148312">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000003">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="9"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5493245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001148312"/>
        </source>
    </evidence>
    <sequence length="189" mass="20975" checksum="B69F263AC4E27607" modified="2023-11-08" version="1">MPLARSNDPLVWIDCEMTGLDPDHDTILQICCIITDAQLNVLDPQGFDAVIHHSDSVLKNMSAWCVDMHGRTGLTAAVRASATSAAEAADSLLAYIRRFVPAPRTALLAGNSVHADKAFLARAPYAQVLEHLHYRLLDVSSLKEAARRWGSEDLLAQVPAKREVHLARDDILESIQEMRFYREKLFGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-11-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9W9XKX8</accession>
    <name>A0A9W9XKX8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Splicing factor YJU2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">N7539_000008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium diatomitis</name>
        <dbReference type="NCBI Taxonomy" id="2819901"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Petersen C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="IMA Fungus" volume="14" first="0" last="0">
            <title>Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.</title>
            <authorList>
                <person name="Petersen C."/>
                <person name="Sorensen T."/>
                <person name="Nielsen M.R."/>
                <person name="Sondergaard T.E."/>
                <person name="Sorensen J.L."/>
                <person name="Fitzpatrick D.A."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.L."/>
            </authorList>
            <dbReference type="PubMed" id="36726175"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IBT 30728</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPWDQ010000001">
        <property type="protein sequence ID" value="KAJ5494892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbR